MODEL1111070002
type: SBMLModel
is described by: http://identifiers.org/pubmed/22041191
species: 985704
reaction: 069549
species: 983829
reaction: 047499
species: 985945
reaction: 018997
species: 984769
species: 981135
reaction: 056299
reaction: 040201
reaction: 029772
species: 981327
species: 984346
species: 980168
reaction: 033986
reaction: 077771
reaction: 989982
reaction: 053958
species: 982668
species: 987437
reaction: 010611
reaction: 026253
reaction: 003101
reaction: 016924
species: 980155
reaction: 998664
reaction: 064848
reaction: 001963
species: 985632
species: 985885
species: 980180
species: 987750
reaction: 057167
reaction: 016320
reaction: 023247
species: 987605
species: 982403
species: 981255
reaction: 060113
species: 985994
species: 984648
species: 984540
compartment: 979960
species: 986572
reaction: 063568
species: 983589
reaction: 038428
reaction: 070383
species: 982788
species: 987569
species: 983407
species: 983733
reaction: 029481
reaction: 020728
substance units: 687672
species: 985364
reaction: 062939
reaction: 005497
reaction: 027933
species: 983102
reaction: 996660
species: 987907
species: 986102
volume units: MODEL1105180000#
reaction: 062530
reaction: 994250
reaction: 062626
species: 984576
reaction: 051221
species: 985873
reaction: 041652
species: 984358
species: 985969
reaction: 020427
species: 985572
reaction: 002180
reaction: 011553
reaction: 043928

985704
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Formate

979936
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Mitochondrion

069549
type: Reaction
notes: GENE_ASSOCIATION: (NM_024664.2 or NM_001077447.1) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
product: 069633
kinetic law: 069645
reversible: false
product: 069597
product: 069621
name: phosphopantothenate-cysteine ligase
product: 069609
reactant: 069585
reactant: 069573
fast: false
reactant: 069561

069633
type: SpeciesReference
stoichiometry: 1.0
species: 984094

984094
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphate

979924
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Cytoplasm

069693
type: LocalParameter
value: 500.0

069681
type: LocalParameter
value: 0.0

069669
type: LocalParameter
value: 1000.0

069657
type: LocalParameter
value: 0.0

069597
type: SpeciesReference
stoichiometry: 1.0
species: 981303

981303
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

069621
type: SpeciesReference
stoichiometry: 1.0
species: 983066

983066
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: H+

069609
type: SpeciesReference
stoichiometry: 1.0
species: 981786

981786
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CDP

069585
type: SpeciesReference
stoichiometry: 1.0
species: 982077

982077
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Cysteine

069573
type: SpeciesReference
stoichiometry: 1.0
species: 982064

982064
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CTP

069561
type: SpeciesReference
stoichiometry: 1.0
species: 981291

981291
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-4'-Phosphopantothenate

983829
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecatrienoyl-CoA (C18:3CoA, n-3)

047499
type: Reaction
kinetic law: 047547
product: 047535
reactant: 047523
reactant: 047511
notes: GENE_ASSOCIATION: NM_012205.1 GENE_LIST: NM_012205.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: true
name: 3-hydroxyanthranilate 3,4-dioxygenase

047595
type: LocalParameter
value: 0.0

047583
type: LocalParameter
value: 0.0

047571
type: LocalParameter
value: 1000.0

047559
type: LocalParameter
value: -1000.0

047535
type: SpeciesReference
stoichiometry: 1.0
species: 981509

981509
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Amino-3-carboxymuconate semialdehyde

047523
type: SpeciesReference
stoichiometry: 1.0
species: 983709

983709
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: O2

047511
type: SpeciesReference
stoichiometry: 1.0
species: 981123

981123
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Hydroxyanthranilate

985945
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: heptadecanoyl CoA (C17:0CoA)

018997
type: Reaction
product: 019033
reactant: 019009
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
kinetic law: 019057
name: carnitine palmitoyltransferase (C16:0Crn), mitochondrial
product: 019045
reactant: 019021
fast: false

019033
type: SpeciesReference
stoichiometry: 1.0
species: 985450

985450
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Carnitine

019009
type: SpeciesReference
stoichiometry: 1.0
species: 985413

985413
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Coenzyme A

019105
type: LocalParameter
value: 0.0

019093
type: LocalParameter
value: 0.0

019081
type: LocalParameter
value: 1000.0

019069
type: LocalParameter
value: -1000.0

019045
type: SpeciesReference
stoichiometry: 1.0
species: 986463

986463
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Palmitoyl-CoA (n-C16:0CoA)

019021
type: SpeciesReference
stoichiometry: 1.0
species: 986475

986475
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Palmitoylcarnitine (C16:0Crn)

984769
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Urea

981135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (R)-3-Hydroxybutanoate

056299
type: Reaction
reversible: true
fast: false
product: 056335
product: 056347
reactant: 056323
kinetic law: 056359
notes: GENE_ASSOCIATION: (NM_018976.3 or NM_030674.2 or NM_001077484.1 or NM_007231.1 or NM_018018.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
name: L-methionine transport in via sodium symport, blood
reactant: 056311

056335
type: SpeciesReference
stoichiometry: 1.0
species: 983468

983468
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Methionine

056347
type: SpeciesReference
stoichiometry: 1.0
species: 983637

983637
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sodium

056323
type: SpeciesReference
stoichiometry: 1.0
species: 980605

980605
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Sodium

979972
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Blood

056408
type: LocalParameter
value: 0.0

056396
type: LocalParameter
value: 0.0

056384
type: LocalParameter
value: 1000.0

056372
type: LocalParameter
value: -1000.0

056311
type: SpeciesReference
stoichiometry: 1.0
species: 980593

980593
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Methionine

040201
type: Reaction
reactant: 040213
notes: GENE_ASSOCIATION: (NM_001081686.1 or NM_000151.1 or NM_021176.1 or NM_138387.2) GENE_LIST: NM_000151.1 NM_001081686.1 NM_021176.1 NM_138387.2 SUBSYSTEM: Pentose Phosphate Pathway
kinetic law: 040261
reactant: 040225
product: 040249
reversible: false
name: glucose-6-phosphatase
fast: false
product: 040237

040213
type: SpeciesReference
stoichiometry: 1.0
species: 986996

986996
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: D-Glucose 6-phosphate

979948
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Endoplasmic_reticulum

040309
type: LocalParameter
value: 500.0

040297
type: LocalParameter
value: 0.0

040285
type: LocalParameter
value: 1000.0

040273
type: LocalParameter
value: 0.0

040225
type: SpeciesReference
stoichiometry: 1.0
species: 987033

987033
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: H2O

040249
type: SpeciesReference
stoichiometry: 1.0
species: 987129

987129
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Phosphate

040237
type: SpeciesReference
stoichiometry: 1.0
species: 987009

987009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: D-Glucose

029772
type: Reaction
product: 029844
product: 029820
kinetic law: 029856
reactant: 029784
reactant: 029796
fast: false
name: fatty-acid--CoA ligase (docosapentaenoate, C22:5 n-3)
product: 029832
reversible: true
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 029808

029844
type: SpeciesReference
stoichiometry: 1.0
species: 984202

984202
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Diphosphate

029820
type: SpeciesReference
stoichiometry: 1.0
species: 981666

981666
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: AMP

029904
type: LocalParameter
value: 0.0

029892
type: LocalParameter
value: 0.0

029880
type: LocalParameter
value: 1000.0

029868
type: LocalParameter
value: -1000.0

029784
type: SpeciesReference
stoichiometry: 1.0
species: 981738

981738
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: ATP

029796
type: SpeciesReference
stoichiometry: 1.0
species: 981991

981991
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Coenzyme A

029832
type: SpeciesReference
stoichiometry: 1.0
species: 982391

982391
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosapentaenoyl-CoA (C22:5CoA, n-3)

029808
type: SpeciesReference
stoichiometry: 1.0
species: 982210

982210
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosapentaenoate (C22:5, n-3)

981327
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Amino-4-oxopentanoate

984346
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Pyruvate

980168
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Creatinine

033986
type: Reaction
reactant: 034035
product: 034059
product: 034084
reactant: 033998
fast: false
reactant: 034010
product: 034072
reactant: 034022
kinetic law: 034108
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_014049.3 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_0061... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_0061... NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
reversible: false
reactant: 034047
product: 034096
name: Beta oxidation of fatty acid

034035
type: SpeciesReference
stoichiometry: 9.0
species: 985848

985848
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: H2O

034059
type: SpeciesReference
stoichiometry: 10.0
species: 985169

985169
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Acetyl-CoA

034084
type: SpeciesReference
stoichiometry: 9.0
species: 985836

985836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: H+

033998
type: SpeciesReference
stoichiometry: 9.0
species: 985413

034010
type: SpeciesReference
stoichiometry: 1.0
species: 985560

985560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: eicosapentaenoyl-CoA (C20:5CoA, n-3)

034072
type: SpeciesReference
stoichiometry: 4.0
species: 985644

985644
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: FADH2

034022
type: SpeciesReference
stoichiometry: 4.0
species: 985632

985632
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: FAD

034156
type: LocalParameter
value: 500.0

034144
type: LocalParameter
value: 0.0

034132
type: LocalParameter
value: 1000.0

034120
type: LocalParameter
value: 0.0

034047
type: SpeciesReference
stoichiometry: 9.0
species: 986150

986150
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Nicotinamide adenine dinucleotide

034096
type: SpeciesReference
stoichiometry: 9.0
species: 986162

986162
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Nicotinamide adenine dinucleotide - reduced

077771
type: Reaction
kinetic law: 077831
fast: false
product: 077819
product: 077807
reactant: 077795
notes: SUBSYSTEM: Pentose Phosphate Pathway
name: transaldolase, endoplasmic reticulum
reversible: true
reactant: 077783

077879
type: LocalParameter
value: 0.0

077867
type: LocalParameter
value: 0.0

077855
type: LocalParameter
value: 1000.0

077843
type: LocalParameter
value: -1000.0

077819
type: SpeciesReference
stoichiometry: 1.0
species: 986947

986947
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: D-Fructose 6-phosphate

077807
type: SpeciesReference
stoichiometry: 1.0
species: 986935

986935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: D-Erythrose 4-phosphate

077795
type: SpeciesReference
stoichiometry: 1.0
species: 987178

987178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Sedoheptulose 7-phosphate

077783
type: SpeciesReference
stoichiometry: 1.0
species: 986984

986984
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Glyceraldehyde 3-phosphate

989982
type: Reaction
kinetic law: 990018
product: 990006
reactant: 989994
fast: false
reversible: true
name: L-Alanine exchange

990066
type: LocalParameter
value: 500.0

990054
type: LocalParameter
value: 0.0

990042
type: LocalParameter
value: 1000.0

990030
type: LocalParameter
value: 0.0

990006
type: SpeciesReference
stoichiometry: 1.0
species: 987497

987497
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ala_L_b

979985
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Extrasystem

989994
type: SpeciesReference
stoichiometry: 1.0
species: 980046

980046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Alanine

053958
type: Reaction
product: 054043
product: 053995
product: 054007
product: 054165
product: 054031
product: 054092
kinetic law: 054189
reversible: false
product: 054117
product: 054080
product: 054019
name: monoacylglycerol hydrolase, human myocyte
reactant: 053970
reactant: 053982
fast: false
product: 054105
product: 054129
notes: GENE_ASSOCIATION: (NM_007283.5 or NM_001003794.1) GENE_LIST: NM_001003794.1 NM_007283.5 SUBSYSTEM: Phospholipid Metabolism
product: 054068
product: 054153
product: 054177
product: 054056
product: 054141

054043
type: SpeciesReference
stoichiometry: 0.119
species: 982535

982535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatetraenoate (C20:4, n-6)

053995
type: SpeciesReference
stoichiometry: 0.028
species: 982198

982198
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosahexaenoate (C22:6, n-3)

054007
type: SpeciesReference
stoichiometry: 0.015
species: 982210

054165
type: SpeciesReference
stoichiometry: 0.002
species: 984322

984322
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: pentadecanoate (C15:0)

054031
type: SpeciesReference
stoichiometry: 0.011
species: 982523

982523
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatrienoate (C20:3, n-6)

054092
type: SpeciesReference
stoichiometry: 0.008
species: 983138

983138
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: hexadecenoate (C16:1, n-7)

054237
type: LocalParameter
value: 500.0

054225
type: LocalParameter
value: 0.0

054213
type: LocalParameter
value: 1000.0

054201
type: LocalParameter
value: 0.0

054117
type: SpeciesReference
stoichiometry: 0.137
species: 983745

983745
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecanoate (n-C18:0)

054080
type: SpeciesReference
stoichiometry: 0.224
species: 983126

983126
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: hexadecanoate (n-C16:0)

054019
type: SpeciesReference
stoichiometry: 0.018
species: 982511

982511
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosapentaenoate (C20:5, n-3)

053970
type: SpeciesReference
stoichiometry: 1.0
species: 983078

983078
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: H2O

053982
type: SpeciesReference
stoichiometry: 0.001
species: 983505

983505
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: monoacylglycerol, human myocyte

054105
type: SpeciesReference
stoichiometry: 0.003
species: 983234

983234
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: heptadecanoate (C17:0)

054129
type: SpeciesReference
stoichiometry: 0.106
species: 983757

983757
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecenoate (C18:1, n-9)

054068
type: SpeciesReference
stoichiometry: 1.0
species: 983066

054153
type: SpeciesReference
stoichiometry: 0.312
species: 983781

983781
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecadienoate (C18:2, n-6)

054177
type: SpeciesReference
stoichiometry: 0.01
species: 984684

984684
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: tetradecanoate (C14:0)

054056
type: SpeciesReference
stoichiometry: 1.0
species: 982957

982957
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Glycerol

054141
type: SpeciesReference
stoichiometry: 0.007
species: 983769

983769
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecatrienoate (C18:3, n-3)

982668
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Average fatty acid, human hepatocyte

987437
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Sarcosine

979960
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Peroxisome

010611
type: Reaction
product: 010707
name: carbamoyl-phosphate synthase (ammonia)
reactant: 010647
product: 010695
notes: GENE_ASSOCIATION: (NM_001875.2 or NM_001122633.1 or NM_001122634.1) GENE_LIST: NM_001122633.1 NM_001122634.1 NM_001875.2 SUBSYSTEM: Arginine Metabolism
reactant: 010623
product: 010683
fast: false
product: 010671
reversible: false
kinetic law: 010719
reactant: 010659
reactant: 010635

010707
type: SpeciesReference
stoichiometry: 1.0
species: 986451

986451
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Phosphate

010647
type: SpeciesReference
stoichiometry: 1.0
species: 985848

010695
type: SpeciesReference
stoichiometry: 3.0
species: 985836

010623
type: SpeciesReference
stoichiometry: 2.0
species: 985279

985279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: ATP

010683
type: SpeciesReference
stoichiometry: 1.0
species: 985316

985316
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Carbamoyl phosphate

010671
type: SpeciesReference
stoichiometry: 2.0
species: 985195

985195
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: ADP

010768
type: LocalParameter
value: 500.0

010755
type: LocalParameter
value: 0.0

010743
type: LocalParameter
value: 1000.0

010731
type: LocalParameter
value: 0.0

010659
type: SpeciesReference
stoichiometry: 1.0
species: 986198

986198
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ammonium

010635
type: SpeciesReference
stoichiometry: 1.0
species: 985400

985400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: CO2

026253
type: Reaction
kinetic law: 026289
product: 026277
reactant: 026265
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: dimethylallyl diphosphate transport, peroxisome

026337
type: LocalParameter
value: 0.0

026325
type: LocalParameter
value: 0.0

026313
type: LocalParameter
value: 1000.0

026301
type: LocalParameter
value: -1000.0

026277
type: SpeciesReference
stoichiometry: 1.0
species: 982343

982343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Dimethylallyl diphosphate

026265
type: SpeciesReference
stoichiometry: 1.0
species: 987317

987317
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Dimethylallyl diphosphate

003101
type: Reaction
reactant: 003125
fast: false
kinetic law: 003185
product: 003173
reversible: false
name: alphaketobutyrate dehydrogenase (mitochondrial)
product: 003161
reactant: 003113
notes: SUBSYSTEM: Threonine Degradation
product: 003149
reactant: 003137

003125
type: SpeciesReference
stoichiometry: 1.0
species: 985413

003233
type: LocalParameter
value: 500.0

003221
type: LocalParameter
value: 0.0

003209
type: LocalParameter
value: 1000.0

003197
type: LocalParameter
value: 0.0

003173
type: SpeciesReference
stoichiometry: 1.0
species: 986500

986500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Propanoyl-CoA (C3:0CoA)

003161
type: SpeciesReference
stoichiometry: 1.0
species: 986162

003113
type: SpeciesReference
stoichiometry: 1.0
species: 984938

984938
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Oxobutanoate

003149
type: SpeciesReference
stoichiometry: 1.0
species: 985400

003137
type: SpeciesReference
stoichiometry: 1.0
species: 986150

016924
type: Reaction
kinetic law: 016984
product: 016972
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 016948
name: carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
product: 016960
reactant: 016936
reversible: true

017032
type: LocalParameter
value: 0.0

017020
type: LocalParameter
value: 0.0

017008
type: LocalParameter
value: 1000.0

016996
type: LocalParameter
value: -1000.0

016972
type: SpeciesReference
stoichiometry: 1.0
species: 986330

986330
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: octadecenoyl carnitine (C18:1Crn, n9)

016948
type: SpeciesReference
stoichiometry: 1.0
species: 986318

986318
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: octadecenoyl-CoA (C18:1CoA, n-9)

016960
type: SpeciesReference
stoichiometry: 1.0
species: 985413

016936
type: SpeciesReference
stoichiometry: 1.0
species: 985450

980155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Carnitine

998664
type: Reaction
reactant: 998688
kinetic law: 998724
reactant: 998676
name: acetyl-CoA C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Isoleucine degradation
product: 998700
fast: false
product: 998712
reversible: true

998688
type: SpeciesReference
stoichiometry: 1.0
species: 985413

998773
type: LocalParameter
value: 0.0

998761
type: LocalParameter
value: 0.0

998749
type: LocalParameter
value: 1000.0

998736
type: LocalParameter
value: -1000.0

998676
type: SpeciesReference
stoichiometry: 1.0
species: 984890

984890
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Methyl-3-acetoacetyl-CoA

998700
type: SpeciesReference
stoichiometry: 1.0
species: 985169

998712
type: SpeciesReference
stoichiometry: 1.0
species: 986500

064848
type: Reaction
product: 064897
fast: false
notes: GENE_ASSOCIATION: (NM_001077197.1 or NM_033430.2 or NM_016953.2 or NM_033437.2 or NM_002599.1 or NM_001083.3 or NM_001077196.1 or NM_001003683.1 or NM_005020.1 or NM_000921.3 or (NM_000283.1 and NM_000440.1 and NM_002601.2 and NM_006204.2 and NM_006205.1) or NM_001001572.1 or NM_001001581.1 or NM_001001570.1 or NM_001001578.1 or NM_001001579.1 or NM_001001576.1 or NM_001001583.1 or (NM_000283.1 and NM_000440.1 and NM_002601.2 and NM_002602.1 and NM_006204.2) or NM_001001568.1 or NM_001001575.1 or NM_001001584.1 or NM_001001582.1 or NM_001001571.1 or NM_001001577.1 or NM_001001569.1 or NM_001001580.1 or NM_001001573.1 or NM_001001585.1 or NM_001001574.1 or NM_001001567.1 or NM_002606.2 or NM_006661.1 or NM_001077358.1 or NM_005019.3 or NM_000924.2 or NM_000922.2) GENE_LIST: NM_000283.1 NM_000440.1 NM_000921.3 NM_000922.2 NM_000924.2 NM_001001567.1 NM_001001568.1 NM_001001569.1 NM_001001570.1 NM_001001571.1 NM_001001572.1 NM_001001573.1 NM_001001574.1 NM_001001575.1 NM_001001576.1 NM_001001577.1 NM_001001578.1 NM_001001579.1 NM_001001580.1 NM_001001581.1 NM_001001582.1 NM_001001583.1 NM_001001584.1 NM_001001585.1 NM_001003683.1 NM_001077196.1 NM_001077197.1 NM_001077358.1 NM_001083.3 NM_002599.1 NM_002601.2 NM_002602.1 NM_002606.2 NM_005019.3 NM_005020.1 NM_006204.2 NM_006205.1 NM_006661.1 NM_016953.2 NM_033430.2 NM_033437.2 SUBSYSTEM: Nucleotides
kinetic law: 064909
reactant: 064860
name: 3',5'-cyclic-nucleotide phosphodiesterase
reactant: 064872
reversible: false
product: 064884

064897
type: SpeciesReference
stoichiometry: 1.0
species: 983066

064957
type: LocalParameter
value: 500.0

064945
type: LocalParameter
value: 0.0

064933
type: LocalParameter
value: 1000.0

064921
type: LocalParameter
value: 0.0

064860
type: SpeciesReference
stoichiometry: 1.0
species: 981846

981846
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3',5'-Cyclic GMP

064872
type: SpeciesReference
stoichiometry: 1.0
species: 983078

064884
type: SpeciesReference
stoichiometry: 1.0
species: 983005

983005
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: GMP

001963
type: Reaction
kinetic law: 002011
product: 001999
product: 001987
reactant: 001975
notes: GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Nucleotide Cycle
fast: false
reversible: true
name: adenylsuccinate lyase

002059
type: LocalParameter
value: 0.0

002047
type: LocalParameter
value: 0.0

002035
type: LocalParameter
value: 1000.0

002023
type: LocalParameter
value: -1000.0

001999
type: SpeciesReference
stoichiometry: 1.0
species: 982812

982812
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Fumarate

001987
type: SpeciesReference
stoichiometry: 1.0
species: 981666

001975
type: SpeciesReference
stoichiometry: 1.0
species: 982150

982150
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N6-(1,2-Dicarboxyethyl)-AMP

985885
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: hexadecenoyl-CoA (C16:1CoA, n-7)

980180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Cysteine

987750
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecsttea3_b

057167
type: Reaction
kinetic law: 057203
product: 057191
reactant: 057179
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde transport, mitochondrial

057252
type: LocalParameter
value: 0.0

057240
type: LocalParameter
value: 0.0

057228
type: LocalParameter
value: 1000.0

057216
type: LocalParameter
value: -1000.0

057191
type: SpeciesReference
stoichiometry: 1.0
species: 983553

983553
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (S)-Methylmalonate semialdehyde

057179
type: SpeciesReference
stoichiometry: 1.0
species: 986114

986114
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-Methylmalonate semialdehyde

016320
type: Reaction
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
name: hexadecenoyl carnitine transprot (C16:1Crn, n7)
reactant: 016344
product: 016356
reactant: 016332
reversible: true
fast: false
kinetic law: 016380
product: 016368

016344
type: SpeciesReference
stoichiometry: 1.0
species: 985450

016356
type: SpeciesReference
stoichiometry: 1.0
species: 982040

982040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Carnitine

016332
type: SpeciesReference
stoichiometry: 1.0
species: 983162

983162
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: hexadecenoyl carnitine (C16:1Crn, n-7)

016428
type: LocalParameter
value: 0.0

016416
type: LocalParameter
value: 0.0

016404
type: LocalParameter
value: 1000.0

016392
type: LocalParameter
value: -1000.0

016368
type: SpeciesReference
stoichiometry: 1.0
species: 985897

985897
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: hexadecenoyl carnitine (C16:1Crn, n-7)

023247
type: Reaction
fast: false
reactant: 023284
reversible: true
reactant: 023271
reactant: 023259
kinetic law: 023320
product: 023296
product: 023308
notes: GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Metabolism
name: CDP-Diacylglycerol synthetase, human myocyte

023284
type: SpeciesReference
stoichiometry: 0.001
species: 983938

983938
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphatidate, Human Myocyte

023271
type: SpeciesReference
stoichiometry: 1.0
species: 983066

023259
type: SpeciesReference
stoichiometry: 1.0
species: 982064

023368
type: LocalParameter
value: 0.0

023356
type: LocalParameter
value: 0.0

023344
type: LocalParameter
value: 1000.0

023332
type: LocalParameter
value: -1000.0

023296
type: SpeciesReference
stoichiometry: 0.001
species: 981810

981810
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CDPdiacylglycerol, human myocyte

023308
type: SpeciesReference
stoichiometry: 1.0
species: 984202

987605
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: crn_b

982403
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosapentaenoyl carnitine (C22:5Crn, n-3)

981255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 4-Imidazolone-5-propanoate

060113
type: Reaction
product: 060161
name: nucleoside-diphosphate kinase (ATP:CDP)
product: 060149
reversible: true
reactant: 060125
notes: GENE_ASSOCIATION: ((NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_013330.3 or NM_197972.1 or (NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_001018138.1) or (NM_001018137.1 and NM_198175.1) or NM_005793.3 or NM_002513.2) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Pyrimidine Metabolism
kinetic law: 060173
fast: false
reactant: 060137

060161
type: SpeciesReference
stoichiometry: 1.0
species: 982064

060149
type: SpeciesReference
stoichiometry: 1.0
species: 981557

981557
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: ADP

060125
type: SpeciesReference
stoichiometry: 1.0
species: 981738

060221
type: LocalParameter
value: 0.0

060209
type: LocalParameter
value: 0.0

060197
type: LocalParameter
value: 1000.0

060185
type: LocalParameter
value: -1000.0

060137
type: SpeciesReference
stoichiometry: 1.0
species: 981786

985994
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Isocitrate

984648
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Triglyceride, Human Myocyte

984540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Tetradecanoyl-CoA (n-C14:0CoA)

986572
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Pyruvate

063568
type: Reaction
reactant: 063592
product: 063604
kinetic law: 063628
fast: false
product: 063616
reactant: 063580
name: orotate phosphoribosyltransferase
reversible: true
notes: GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Pyrimidine Metabolism

063592
type: SpeciesReference
stoichiometry: 1.0
species: 984202

063604
type: SpeciesReference
stoichiometry: 1.0
species: 983902

983902
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Orotate

063676
type: LocalParameter
value: 0.0

063664
type: LocalParameter
value: 0.0

063652
type: LocalParameter
value: 1000.0

063640
type: LocalParameter
value: -1000.0

063616
type: SpeciesReference
stoichiometry: 1.0
species: 984274

984274
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Phospho-alpha-D-ribose 1-diphosphate

063580
type: SpeciesReference
stoichiometry: 1.0
species: 983914

983914
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Orotidine 5'-phosphate

983589
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Myosin-Actin-ADP

038428
type: Reaction
reactant: 038440
product: 038464
reactant: 038452
fast: false
reversible: false
name: fructokinase
notes: GENE_ASSOCIATION: (NM_000188.1 or NM_000189.4 or NM_002115.1 or NM_033497.1) GENE_LIST: NM_000188.1 NM_000189.4 NM_002115.1 NM_033497.1 SUBSYSTEM: Fructose and Mannose Metabolism
product: 038476
kinetic law: 038500
product: 038488

038440
type: SpeciesReference
stoichiometry: 1.0
species: 981738

038464
type: SpeciesReference
stoichiometry: 1.0
species: 981557

038452
type: SpeciesReference
stoichiometry: 1.0
species: 982800

982800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Fructose

038476
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species: 982656

982656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Fructose 6-phosphate

038549
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038537
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value: 0.0

038525
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value: 1000.0

038512
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value: 0.0

038488
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species: 983066

070383
type: Reaction
product: 070448
reactant: 070396
product: 070461
kinetic law: 070474
product: 070435
reactant: 070409
product: 070422
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine Metabolism
fast: false
reversible: false
name: phosphoribosylaminoimidazole synthetase

070448
type: SpeciesReference
stoichiometry: 1.0
species: 983066

070396
type: SpeciesReference
stoichiometry: 1.0
species: 981738

070461
type: SpeciesReference
stoichiometry: 1.0
species: 984094

070527
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value: 500.0

070514
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value: 0.0

070500
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value: 1000.0

070487
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value: 0.0

070435
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stoichiometry: 1.0
species: 981605

981605
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole

070409
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stoichiometry: 1.0
species: 982764

982764
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine

070422
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stoichiometry: 1.0
species: 981557

982788
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Farnesyl diphosphate

987569
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: chsterol_b

983407
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Malate

983733
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Oxaloacetate

029481
type: Reaction
reactant: 029506
reactant: 029518
product: 029530
product: 029542
reactant: 029493
name: fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
fast: false
reversible: true
product: 029554
kinetic law: 029566
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203380.1 or NM_015256.2 or NM_001995.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis

029506
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stoichiometry: 1.0
species: 981991

029518
type: SpeciesReference
stoichiometry: 1.0
species: 982535

029530
type: SpeciesReference
stoichiometry: 1.0
species: 981666

029542
type: SpeciesReference
stoichiometry: 1.0
species: 982619

982619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)

029493
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stoichiometry: 1.0
species: 981738

029554
type: SpeciesReference
stoichiometry: 1.0
species: 984202

029614
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value: 0.0

029602
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value: 0.0

029590
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value: 1000.0

029578
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value: -1000.0

020728
type: Reaction
reactant: 020752
reversible: false
reactant: 020776
product: 020825
product: 020813
product: 020788
name: CTP synthase (glutamine)
reactant: 020764
kinetic law: 020849
reactant: 020740
notes: GENE_ASSOCIATION: (NM_175859.1 or NM_019857.3) GENE_LIST: NM_019857.3 NM_175859.1 SUBSYSTEM: Pyrimidine Metabolism
product: 020837
product: 020800
fast: false

020752
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stoichiometry: 1.0
species: 982897

982897
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Glutamine

020776
type: SpeciesReference
stoichiometry: 1.0
species: 984793

984793
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: UTP

020825
type: SpeciesReference
stoichiometry: 2.0
species: 983066

020813
type: SpeciesReference
stoichiometry: 1.0
species: 982909

982909
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Glutamate

020788
type: SpeciesReference
stoichiometry: 1.0
species: 981557

020764
type: SpeciesReference
stoichiometry: 1.0
species: 983078

020897
type: LocalParameter
value: 500.0

020885
type: LocalParameter
value: 0.0

020873
type: LocalParameter
value: 1000.0

020861
type: LocalParameter
value: 0.0

020740
type: SpeciesReference
stoichiometry: 1.0
species: 981738

020837
type: SpeciesReference
stoichiometry: 1.0
species: 984094

020800
type: SpeciesReference
stoichiometry: 1.0
species: 982064

985364
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Citrulline

062939
type: Reaction
reactant: 062963
product: 062975
notes: GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Pyrimidine Metabolism
reversible: false
kinetic law: 062999
name: orotidine-5'-phosphate decarboxylase
reactant: 062951
fast: false
product: 062987

062963
type: SpeciesReference
stoichiometry: 1.0
species: 983914

062975
type: SpeciesReference
stoichiometry: 1.0
species: 981979

981979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CO2

063048
type: LocalParameter
value: 500.0

063036
type: LocalParameter
value: 0.0

063023
type: LocalParameter
value: 1000.0

063011
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value: 0.0

062951
type: SpeciesReference
stoichiometry: 1.0
species: 983066

062987
type: SpeciesReference
stoichiometry: 1.0
species: 984733

984733
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: UMP

005497
type: Reaction
product: 005559
fast: false
reactant: 005509
product: 005571
reversible: false
name: amine oxidase (putrescine)
notes: SUBSYSTEM: Glutamate Metabolism
reactant: 005521
product: 005546
reactant: 005533
kinetic law: 005583

005559
type: SpeciesReference
stoichiometry: 1.0
species: 983090

983090
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Hydrogen peroxide

005509
type: SpeciesReference
stoichiometry: 1.0
species: 983078

005571
type: SpeciesReference
stoichiometry: 1.0
species: 983697

983697
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Ammonium

005521
type: SpeciesReference
stoichiometry: 1.0
species: 983709

005546
type: SpeciesReference
stoichiometry: 1.0
species: 981231

981231
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 4-Aminobutanal

005533
type: SpeciesReference
stoichiometry: 1.0
species: 984334

984334
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Putrescine

005633
type: LocalParameter
value: 500.0

005620
type: LocalParameter
value: 0.0

005608
type: LocalParameter
value: 1000.0

005596
type: LocalParameter
value: 0.0

027933
type: Reaction
kinetic law: 027970
product: 027958
reactant: 027946
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ethanol transport in/out via diffusion

028019
type: LocalParameter
value: 0.0

028006
type: LocalParameter
value: 0.0

027994
type: LocalParameter
value: 1000.0

027982
type: LocalParameter
value: -1000.0

027958
type: SpeciesReference
stoichiometry: 1.0
species: 980326

980326
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Ethanol

027946
type: SpeciesReference
stoichiometry: 1.0
species: 982595

982595
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Ethanol

983102
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Bicarbonate

996660
type: Reaction
kinetic law: 996696
product: 996684
reactant: 996672
fast: false
reversible: true
name: L-Tyrosine exchange

996744
type: LocalParameter
value: 500.0

996732
type: LocalParameter
value: 0.0

996720
type: LocalParameter
value: 1000.0

996708
type: LocalParameter
value: 0.0

996684
type: SpeciesReference
stoichiometry: 1.0
species: 988333

988333
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: tyr_L_b

996672
type: SpeciesReference
stoichiometry: 1.0
species: 980892

980892
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Tyrosine

987907
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: hco3_b

986102
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Methylmalonate

062530
type: Reaction
kinetic law: 062566
product: 062554
reactant: 062542
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: octadecenoate (C18:1, n-9)transport

062614
type: LocalParameter
value: 0.0

062602
type: LocalParameter
value: 0.0

062590
type: LocalParameter
value: 1000.0

062578
type: LocalParameter
value: -1000.0

062554
type: SpeciesReference
stoichiometry: 1.0
species: 980654

980654
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: octadecenoate (C18:1, n-9)

062542
type: SpeciesReference
stoichiometry: 1.0
species: 983757

994250
type: Reaction
kinetic law: 994286
product: 994274
reactant: 994262
fast: false
reversible: true
name: D-Mannose exchange

994336
type: LocalParameter
value: 500.0

994323
type: LocalParameter
value: 0.0

994311
type: LocalParameter
value: 1000.0

994298
type: LocalParameter
value: 0.0

994274
type: SpeciesReference
stoichiometry: 1.0
species: 988029

988029
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: man_b

994262
type: SpeciesReference
stoichiometry: 1.0
species: 980581

980581
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: D-Mannose

062626
type: Reaction
kinetic law: 062662
product: 062650
reactant: 062638
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecatrienoate (C18:3, n-3) transport

062710
type: LocalParameter
value: 0.0

062698
type: LocalParameter
value: 0.0

062686
type: LocalParameter
value: 1000.0

062674
type: LocalParameter
value: -1000.0

062650
type: SpeciesReference
stoichiometry: 1.0
species: 983769

062638
type: SpeciesReference
stoichiometry: 1.0
species: 980667

980667
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: octadecatrienoate (C18:3, n-3)

984576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5,6,7,8-Tetrahydrofolate

051221
type: Reaction
kinetic law: 051269
product: 051257
reactant: 051245
reactant: 051233
notes: GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine Metabolism
fast: false
reversible: true
name: IMP cyclohydrolase

051317
type: LocalParameter
value: 0.0

051305
type: LocalParameter
value: 0.0

051293
type: LocalParameter
value: 1000.0

051281
type: LocalParameter
value: -1000.0

051257
type: SpeciesReference
stoichiometry: 1.0
species: 982776

982776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

051245
type: SpeciesReference
stoichiometry: 1.0
species: 983297

983297
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: IMP

051233
type: SpeciesReference
stoichiometry: 1.0
species: 983078

985873
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Bicarbonate

041652
type: Reaction
notes: GENE_ASSOCIATION: (NM_000159.2 or NM_013976.2) GENE_LIST: NM_000159.2 NM_013976.2 SUBSYSTEM: Lysine Degradation
fast: false
reactant: 041689
reactant: 041677
reversible: true
product: 041701
product: 041713
kinetic law: 041737
name: glutaryl-CoA dehydrogenase, mitochondrial
reactant: 041664
product: 041725

041689
type: SpeciesReference
stoichiometry: 1.0
species: 985836

041677
type: SpeciesReference
stoichiometry: 1.0
species: 985788

985788
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Glutaryl-CoA

041701
type: SpeciesReference
stoichiometry: 1.0
species: 985291

985291
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: trans-But-2-enoyl-CoA

041713
type: SpeciesReference
stoichiometry: 1.0
species: 985400

041786
type: LocalParameter
value: 0.0

041773
type: LocalParameter
value: 0.0

041761
type: LocalParameter
value: 1000.0

041749
type: LocalParameter
value: -1000.0

041664
type: SpeciesReference
stoichiometry: 1.0
species: 985632

041725
type: SpeciesReference
stoichiometry: 1.0
species: 985644

984358
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: alpha-D-Ribose 5-phosphate

985969
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Hexanoyl-CoA (C6:0CoA)

020427
type: Reaction
reversible: false
product: 020499
product: 020475
kinetic law: 020511
name: citrate synthase
reactant: 020439
reactant: 020463
product: 020487
fast: false
notes: GENE_ASSOCIATION: (NM_004077.2 or NM_198324.1) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citric Acid Cycle
reactant: 020451

020499
type: SpeciesReference
stoichiometry: 1.0
species: 985836

020475
type: SpeciesReference
stoichiometry: 1.0
species: 985352

985352
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Citrate

020560
type: LocalParameter
value: 500.0

020548
type: LocalParameter
value: 0.0

020536
type: LocalParameter
value: 1000.0

020523
type: LocalParameter
value: 0.0

020439
type: SpeciesReference
stoichiometry: 1.0
species: 985169

020463
type: SpeciesReference
stoichiometry: 1.0
species: 986246

986246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Oxaloacetate

020487
type: SpeciesReference
stoichiometry: 1.0
species: 985413

020451
type: SpeciesReference
stoichiometry: 1.0
species: 985848

985572
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: eicosapentaenoyl carnitine (C20:5Crn, n-3)

002180
type: Reaction
product: 002228
product: 002240
reversible: false
product: 002264
reactant: 002192
reactant: 002216
kinetic law: 002276
reactant: 002204
product: 002252
fast: false
notes: GENE_ASSOCIATION: (NM_152328.3 or NM_199165.1 or NM_001126.2) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Purine Nucleotide Cycle
name: adenylosuccinate synthetase

002228
type: SpeciesReference
stoichiometry: 1.0
species: 982150

002240
type: SpeciesReference
stoichiometry: 1.0
species: 982873

982873
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: GDP

002264
type: SpeciesReference
stoichiometry: 1.0
species: 984094

002192
type: SpeciesReference
stoichiometry: 1.0
species: 981726

981726
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Aspartate

002216
type: SpeciesReference
stoichiometry: 1.0
species: 983297

002325
type: LocalParameter
value: 500.0

002313
type: LocalParameter
value: 0.0

002301
type: LocalParameter
value: 1000.0

002288
type: LocalParameter
value: 0.0

002204
type: SpeciesReference
stoichiometry: 1.0
species: 983054

983054
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: GTP

002252
type: SpeciesReference
stoichiometry: 2.0
species: 983066

011553
type: Reaction
name: Choline kinase
reactant: 011565
notes: GENE_ASSOCIATION: (NM_005198.3 or NM_212469.1 or NM_001277.2 or NM_152253.1) GENE_LIST: NM_001277.2 NM_005198.3 NM_152253.1 NM_212469.1 SUBSYSTEM: Phospholipid Metabolism
product: 011601
kinetic law: 011626
product: 011589
reversible: false
fast: false
product: 011613
reactant: 011577

011565
type: SpeciesReference
stoichiometry: 1.0
species: 981738

011601
type: SpeciesReference
stoichiometry: 1.0
species: 981870

981870
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Choline phosphate

011675
type: LocalParameter
value: 500.0

011663
type: LocalParameter
value: 0.0

011651
type: LocalParameter
value: 1000.0

011638
type: LocalParameter
value: 0.0

011589
type: SpeciesReference
stoichiometry: 1.0
species: 981557

011613
type: SpeciesReference
stoichiometry: 1.0
species: 983066

011577
type: SpeciesReference
stoichiometry: 1.0
species: 981858

981858
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Choline

043928
type: Reaction
product: 043965
reactant: 043941
name: glutaminase, mitochondrial
kinetic law: 043989
reactant: 043953
notes: GENE_ASSOCIATION: (NM_014905.2 or NM_013267.2) GENE_LIST: NM_013267.2 NM_014905.2 SUBSYSTEM: Glutamate metabolism
reversible: false
fast: false
product: 043977

043965
type: SpeciesReference
stoichiometry: 1.0
species: 985752

985752
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Glutamate

043941
type: SpeciesReference
stoichiometry: 1.0
species: 985740

985740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Glutamine

044038
type: LocalParameter
value: 500.0

044025
type: LocalParameter
value: 0.0

044013
type: LocalParameter
value: 1000.0

044001
type: LocalParameter
value: 0.0

043953
type: SpeciesReference
stoichiometry: 1.0
species: 985848

043977
type: SpeciesReference
stoichiometry: 1.0
species: 986198

008797
type: Reaction
product: 008858
name: ATP synthase, mitochondrial
notes: GENE_ASSOCIATION: (((NM_022745.2 or NM_001042546) and NM_145691.3 and MT4509 and MT4508 and NM_001688.4 and (NM_001002031.2 or NM_005176.5) and (NM_006356.2 or NM_001003785.1) and NM_007100.2 and (NM_001039178.1 or NM_001003713.1 or NM_001003714.1 or NM_004889.2) and (NM_001003703.1 or NM_001003696.1 or NM_001003697.1 or NM_001003701.1 or NM_001685.4) and NM_006476.4 and (NM_015684.2 or NM_001003805.1 or NM_001003803.1) and NM_001697.2 and (NM_004046.4 or NM_001001937.1) and NM_001686.3 and (NM_001687.4 or NM_001001975.1) and (NM_001001977.1 or NM_006886.2) and (NM_005174.2 or NM_001001973.1)) or ((NM_022745.2 or NM_001042546) and NM_145691.3 and MT4509 and MT4508 and NM_001688.4 and (NM_001002258.2 or NM_001689.3) and (NM_006356.2 or NM_001003785.1) and NM_007100.2 and (NM_001039178.1 or NM_001003713.1 or NM_001003714.1 or NM_004889.2) and (NM_001003703.1 or NM_001003696.... GENE_LIST: MT4508 MT4509 NM_001001937.1 NM_001001973.1 NM_001001975.1 NM_001001977.1 NM_001002031.2 NM_001002258.2 NM_001003696.... NM_001003696.1 NM_001003697.1 NM_001003701.1 NM_001003703.1 NM_001003713.1 NM_001003714.1 NM_001003785.1 NM_001003803.1 NM_001003805.1 NM_001039178.1 NM_001042546 NM_001685.4 NM_001686.3 NM_001687.4 NM_001688.4 NM_001689.3 NM_001697.2 NM_004046.4 NM_004889.2 NM_005174.2 NM_005176.5 NM_006356.2 NM_006476.4 NM_006886.2 NM_007100.2 NM_015684.2 NM_022745.2 NM_145691.3 SUBSYSTEM: Oxidative Phosphorylation
reactant: 008809
reactant: 008833
product: 008870
fast: false
reactant: 008821
kinetic law: 008883
reversible: false
product: 008845

008858
type: SpeciesReference
stoichiometry: 3.0
species: 985836

008809
type: SpeciesReference
stoichiometry: 4.0
species: 983066

008833
type: SpeciesReference
stoichiometry: 1.0
species: 986451

008870
type: SpeciesReference
stoichiometry: 1.0
species: 985848

008821
type: SpeciesReference
stoichiometry: 1.0
species: 985195

008931
type: LocalParameter
value: 500.0

008919
type: LocalParameter
value: 0.0

008907
type: LocalParameter
value: 1000.0

008895
type: LocalParameter
value: 0.0

008845
type: SpeciesReference
stoichiometry: 1.0
species: 985279

023900
type: Reaction
kinetic law: 023936
product: 023924
reactant: 023912
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Docosapentaenoate (C22:5, n-3)

023984
type: LocalParameter
value: 0.0

023972
type: LocalParameter
value: 0.0

023960
type: LocalParameter
value: 1000.0

023948
type: LocalParameter
value: -1000.0

023924
type: SpeciesReference
stoichiometry: 1.0
species: 982210

023912
type: SpeciesReference
stoichiometry: 1.0
species: 980204

980204
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: docosapentaenoate (C22:5, n-3)

005341
type: Reaction
fast: false
reactant: 005389
product: 005401
reversible: false
reactant: 005365
kinetic law: 005437
name: 2-aminomuconate reductase
product: 005413
product: 005425
notes: SUBSYSTEM: Tryptophan metabolism
reactant: 005377
reactant: 005353

005389
type: SpeciesReference
stoichiometry: 1.0
species: 983685

983685
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Nicotinamide adenine dinucleotide phosphate - reduced

005401
type: SpeciesReference
stoichiometry: 1.0
species: 981075

981075
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Oxoadipate

005365
type: SpeciesReference
stoichiometry: 1.0
species: 983066

005485
type: LocalParameter
value: 500.0

005473
type: LocalParameter
value: 0.0

005461
type: LocalParameter
value: 1000.0

005449
type: LocalParameter
value: 0.0

005413
type: SpeciesReference
stoichiometry: 1.0
species: 983673

983673
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Nicotinamide adenine dinucleotide phosphate

005425
type: SpeciesReference
stoichiometry: 1.0
species: 983697

005377
type: SpeciesReference
stoichiometry: 1.0
species: 983078

005353
type: SpeciesReference
stoichiometry: 1.0
species: 981039

981039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Aminomuconate

031039
type: Reaction
kinetic law: 031075
product: 031063
reactant: 031051
notes: SUBSYSTEM: Glycine and Serine Metabolism
fast: false
reversible: true
name: formaldehyde transport, peroxisomal

031123
type: LocalParameter
value: 0.0

031111
type: LocalParameter
value: 0.0

031099
type: LocalParameter
value: 1000.0

031087
type: LocalParameter
value: -1000.0

031063
type: SpeciesReference
stoichiometry: 1.0
species: 987329

987329
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Formaldehyde

031051
type: SpeciesReference
stoichiometry: 1.0
species: 982692

982692
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Formaldehyde

990952
type: Reaction
kinetic law: 990988
product: 990976
reactant: 990964
fast: false
reversible: true
name: Creatinine exchange

991036
type: LocalParameter
value: 500.0

991024
type: LocalParameter
value: 0.0

991012
type: LocalParameter
value: 1000.0

991000
type: LocalParameter
value: 0.0

990976
type: SpeciesReference
stoichiometry: 1.0
species: 987617

987617
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: crtn_b

990964
type: SpeciesReference
stoichiometry: 1.0
species: 980168

047041
type: Reaction
kinetic law: 047077
product: 047065
reactant: 047053
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: H2O endoplasmic reticulum transport

047126
type: LocalParameter
value: 0.0

047114
type: LocalParameter
value: 0.0

047101
type: LocalParameter
value: 1000.0

047089
type: LocalParameter
value: -1000.0

047065
type: SpeciesReference
stoichiometry: 1.0
species: 987033

047053
type: SpeciesReference
stoichiometry: 1.0
species: 983078

999124
type: Reaction
kinetic law: 999184
reactant: 999148
name: acetoacetate transport via proton symport, mitochondrial
product: 999172
fast: false
product: 999160
reversible: true
reactant: 999136
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial

999233
type: LocalParameter
value: 0.0

999221
type: LocalParameter
value: 0.0

999209
type: LocalParameter
value: 1000.0

999196
type: LocalParameter
value: -1000.0

999148
type: SpeciesReference
stoichiometry: 1.0
species: 983066

999172
type: SpeciesReference
stoichiometry: 1.0
species: 985836

999160
type: SpeciesReference
stoichiometry: 1.0
species: 985156

985156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Acetoacetate

999136
type: SpeciesReference
stoichiometry: 1.0
species: 981472

981472
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Acetoacetate

048795
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine degradation
product: 048855
reactant: 048819
name: 3-hydroxyisobutyrate dehydrogenase, mitochondrial
product: 048843
kinetic law: 048867
reactant: 048807
product: 048831

048855
type: SpeciesReference
stoichiometry: 1.0
species: 986162

048819
type: SpeciesReference
stoichiometry: 1.0
species: 986150

048843
type: SpeciesReference
stoichiometry: 1.0
species: 986114

048915
type: LocalParameter
value: 0.0

048903
type: LocalParameter
value: 0.0

048891
type: LocalParameter
value: 1000.0

048879
type: LocalParameter
value: -1000.0

048807
type: SpeciesReference
stoichiometry: 1.0
species: 984998

984998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-hydroxyisobutyrate

048831
type: SpeciesReference
stoichiometry: 1.0
species: 985836

027536
type: Reaction
kinetic law: 027572
product: 027560
reactant: 027548
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosapentaenoate (C20:5, n-3) transport

027620
type: LocalParameter
value: 0.0

027608
type: LocalParameter
value: 0.0

027596
type: LocalParameter
value: 1000.0

027584
type: LocalParameter
value: -1000.0

027560
type: SpeciesReference
stoichiometry: 1.0
species: 982511

027548
type: SpeciesReference
stoichiometry: 1.0
species: 980265

980265
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: eicosapentaenoate (C20:5, n-3)

019845
type: Reaction
kinetic law: 019881
product: 019869
reactant: 019857
notes: GENE_ASSOCIATION: (NM_001099646.1 or NM_152908.2 or NM_018242.2) GENE_LIST: NM_001099646.1 NM_018242.2 NM_152908.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: creatinine transport, blood

019930
type: LocalParameter
value: 500.0

019918
type: LocalParameter
value: 0.0

019906
type: LocalParameter
value: 1000.0

019893
type: LocalParameter
value: 0.0

019869
type: SpeciesReference
stoichiometry: 1.0
species: 980168

019857
type: SpeciesReference
stoichiometry: 1.0
species: 982052

982052
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Creatinine

981460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Acetate

992701
type: Reaction
kinetic law: 992740
product: 992728
reactant: 992715
fast: false
reversible: true
name: L-Glutamine exchange

992788
type: LocalParameter
value: 500.0

992776
type: LocalParameter
value: 0.0

992764
type: LocalParameter
value: 1000.0

992752
type: LocalParameter
value: 0.0

992728
type: SpeciesReference
stoichiometry: 1.0
species: 987835

987835
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: gln_L_b

992715
type: SpeciesReference
stoichiometry: 1.0
species: 980387

980387
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Glutamine

985656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Formaldehyde

995311
type: Reaction
kinetic law: 995347
product: 995335
reactant: 995323
fast: false
reversible: true
name: Ornithine exchange

995396
type: LocalParameter
value: 500.0

995383
type: LocalParameter
value: 0.0

995371
type: LocalParameter
value: 1000.0

995359
type: LocalParameter
value: 0.0

995335
type: SpeciesReference
stoichiometry: 1.0
species: 988162

988162
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: orn_L_b

995323
type: SpeciesReference
stoichiometry: 1.0
species: 980719

980719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Ornithine

984455
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sphingomyeline, human myocyte

982571
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatrienoyl-CoA (C20:3CoA, n-6)

980617
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Ammonium

075130
type: Reaction
fast: false
reactant: 075142
reversible: true
name: L-serine/L-threonine exchange, blood
reactant: 075154
product: 075166
kinetic law: 075190
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
product: 075178

075142
type: SpeciesReference
stoichiometry: 1.0
species: 980818

980818
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Serine

075154
type: SpeciesReference
stoichiometry: 1.0
species: 984588

984588
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Threonine

075166
type: SpeciesReference
stoichiometry: 1.0
species: 980843

980843
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Threonine

075238
type: LocalParameter
value: 0.0

075226
type: LocalParameter
value: 0.0

075214
type: LocalParameter
value: 1000.0

075202
type: LocalParameter
value: -1000.0

075178
type: SpeciesReference
stoichiometry: 1.0
species: 984418

984418
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Serine

987629
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: cys_L_b

045732
type: Reaction
reactant: 045769
product: 045793
kinetic law: 045817
reactant: 045745
product: 045781
reversible: false
product: 045805
name: GMP reductase
fast: false
reactant: 045757
notes: GENE_ASSOCIATION: (NM_001002000.1 or NM_001002001.1 or NM_016576.3 or NM_006877.3 or NM_001002002.1) GENE_LIST: NM_001002000.1 NM_001002001.1 NM_001002002.1 NM_006877.3 NM_016576.3 SUBSYSTEM: Purine Metabolism

045769
type: SpeciesReference
stoichiometry: 1.0
species: 983685

045793
type: SpeciesReference
stoichiometry: 1.0
species: 983673

045867
type: LocalParameter
value: 500.0

045855
type: LocalParameter
value: 0.0

045843
type: LocalParameter
value: 1000.0

045830
type: LocalParameter
value: 0.0

045745
type: SpeciesReference
stoichiometry: 1.0
species: 983005

045781
type: SpeciesReference
stoichiometry: 1.0
species: 983297

045805
type: SpeciesReference
stoichiometry: 1.0
species: 983697

045757
type: SpeciesReference
stoichiometry: 2.0
species: 983066

060595
type: Reaction
product: 060643
reactant: 060619
name: nucleoside-diphosphate kinase (ATP:dUDP)
reversible: true
product: 060631
kinetic law: 060655
fast: false
notes: GENE_ASSOCIATION: ((NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or (NM_000269.2 and NM_001018139.1) or NM_005793.3 or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or NM_013330.3 or NM_002513.2 or (NM_000269.2 and NM_001018138.1) or (NM_001018137.1 and NM_198175.1) or NM_197972.1) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Pyrimidine Metabolism
reactant: 060607

060643
type: SpeciesReference
stoichiometry: 1.0
species: 982487

982487
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dUTP

060619
type: SpeciesReference
stoichiometry: 1.0
species: 982451

982451
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dUDP

060631
type: SpeciesReference
stoichiometry: 1.0
species: 981557

060703
type: LocalParameter
value: 0.0

060691
type: LocalParameter
value: 0.0

060679
type: LocalParameter
value: 1000.0

060667
type: LocalParameter
value: -1000.0

060607
type: SpeciesReference
stoichiometry: 1.0
species: 981738

066435
type: Reaction
notes: SUBSYSTEM: Phospholipid Metabolism
kinetic law: 066495
fast: false
product: 066471
name: phosphatidylglycerol phosphate phosphatase A, mitochondrial, human myocyte
product: 066483
reactant: 066447
reversible: false
reactant: 066459

066543
type: LocalParameter
value: 500.0

066531
type: LocalParameter
value: 0.0

066519
type: LocalParameter
value: 1000.0

066507
type: LocalParameter
value: 0.0

066471
type: SpeciesReference
stoichiometry: 0.001
species: 986415

986415
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: phosphatidylglycerol, Human Myocyte

066483
type: SpeciesReference
stoichiometry: 1.0
species: 986451

066447
type: SpeciesReference
stoichiometry: 1.0
species: 985848

066459
type: SpeciesReference
stoichiometry: 0.001
species: 986427

986427
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Phosphatidylglycerophosphate, human myocyte

053319
type: Reaction
reactant: 053356
name: cytochrome P450 lanosterol 14-alpha-demethylase
reactant: 053331
product: 053392
product: 053380
product: 053416
product: 053404
reversible: false
reactant: 053343
fast: false
reactant: 053368
kinetic law: 053428
notes: GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Metabolism

053356
type: SpeciesReference
stoichiometry: 3.0
species: 987105

987105
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Nicotinamide adenine dinucleotide phosphate - reduced

053331
type: SpeciesReference
stoichiometry: 2.0
species: 987021

987021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: H+

053392
type: SpeciesReference
stoichiometry: 1.0
species: 986959

986959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Formate

053380
type: SpeciesReference
stoichiometry: 1.0
species: 986777

986777
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 4,4-dimethylcholesta-8,14,24-trienol

053416
type: SpeciesReference
stoichiometry: 3.0
species: 987093

987093
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Nicotinamide adenine dinucleotide phosphate

053404
type: SpeciesReference
stoichiometry: 4.0
species: 987033

053343
type: SpeciesReference
stoichiometry: 1.0
species: 987045

987045
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Lanosterol

053368
type: SpeciesReference
stoichiometry: 3.0
species: 987117

987117
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: O2

053476
type: LocalParameter
value: 500.0

053464
type: LocalParameter
value: 0.0

053452
type: LocalParameter
value: 1000.0

053440
type: LocalParameter
value: 0.0

982427
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dTMP

981279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 4-Methyl-2-oxopentanoate

028755
type: Reaction
product: 028803
reversible: true
reactant: 028767
kinetic law: 028839
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_022977.1 or NM_001009185.1 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_203379.1 or NM_203380.1 or NM_016234.3 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 028779
reactant: 028791
fast: false
name: fatty-acid--CoA ligase (octadecanoate)
product: 028815
product: 028827

028803
type: SpeciesReference
stoichiometry: 1.0
species: 981666

028767
type: SpeciesReference
stoichiometry: 1.0
species: 981738

028887
type: LocalParameter
value: 0.0

028875
type: LocalParameter
value: 0.0

028863
type: LocalParameter
value: 1000.0

028851
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value: -1000.0

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984504
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product: 008215
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008264
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008252
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981617
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name: 2-Oxoglutarate

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species: 982909

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983455
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018876
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kinetic law: 018937
name: carnitine O-palmitoyltransferase (C16:0Crn)

018888
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species: 982040

018901
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species: 984130

984130
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018925
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984142
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018973
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018961
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018949
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981423
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name: L-Formylkynurenine

984564
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001259
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notes: GENE_ASSOCIATION: (NM_013356.1 or NM_003051.3 or NM_004696.1 or NM_004731.3 or NM_001042422.1 or NM_001042423.1 or NM_004207.1 or NM_004695.2 or NM_004694.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1
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reactant: 001283
product: 001295

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001356
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001344
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001332
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001307
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species: 983066

001271
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species: 980022

980022
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001295
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018754
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reactant: 018766
product: 018790
product: 018803
fast: false
kinetic law: 018816

018778
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species: 986367

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initial concentration: NaN
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name: propionyl-carnitine

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018852
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018840
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reactant: 989060
reactant: 989387
reactant: 989460
reactant: 989036
reactant: 989170
reactant: 989448
reactant: 989146
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reactant: 989243
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reactant: 989327
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reactant: 989424
reactant: 989122
reactant: 989279
kinetic law: 989533
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reactant: 989399
reactant: 989472
reactant: 989048
reactant: 989182
reactant: 989303
reactant: 989206
reactant: 989158
reactant: 989255
name: Biomass Demand, Human Myocyte (biosynthetic GAM)
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reactant: 989351
reactant: 989375
reactant: 989024
product: 989484
reactant: 989436
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reactant: 989134
reactant: 989084
product: 989497
reactant: 989230
reactant: 989194
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reactant: 989097
reactant: 989339
reactant: 989291
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initial amount: NaN
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species: 981738

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species: 984418

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species: 984793

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species: 981714

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initial concentration: NaN
initial amount: NaN
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name: L-Asparagine

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species: 984696

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initial amount: NaN
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species: 982222

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initial amount: NaN
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species: 984202

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species: 983078

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species: 984034

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initial concentration: NaN
initial amount: NaN
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species: 981629

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initial concentration: NaN
initial amount: NaN
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species: 984648

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species: 982077

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species: 983371

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initial concentration: NaN
initial amount: NaN
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species: 981895

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initial amount: NaN
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species: 984455

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species: 984805

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initial concentration: NaN
initial amount: NaN
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species: 981726

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species: 982897

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species: 983468

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species: 982945

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initial concentration: NaN
initial amount: NaN
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species: 982282

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initial concentration: NaN
initial amount: NaN
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species: 983186

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initial concentration: NaN
initial amount: NaN
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species: 984094

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species: 984118

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initial concentration: NaN
initial amount: NaN
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species: 984298

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initial concentration: NaN
initial amount: NaN
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name: Phosphatidylserine, human myocyte

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species: 981690

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initial concentration: NaN
initial amount: NaN
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name: L-Arginine

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species: 981557

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species: 984660

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initial concentration: NaN
initial amount: NaN
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name: L-Tryptophan

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species: 982064

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species: 982125

982125
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initial amount: NaN
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species: 981907

981907
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Cholesterol

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species: 983066

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species: 983054

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species: 982909

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species: 983974

983974
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initial concentration: NaN
initial amount: NaN
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species: 981955

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initial concentration: NaN
initial amount: NaN
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name: cardiolipin, myocyte

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species: 984058

984058
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has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: L-Phenylalanine

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species: 983395

983395
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constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
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species: 984588

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species: 983284

983284
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initial concentration: NaN
initial amount: NaN
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name: L-Isoleucine

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initial concentration: NaN
initial amount: NaN
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name: O-Phospho-L-serine

019482
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reactant: 019506
reactant: 019494
kinetic law: 019542
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
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name: tetradecanoyl carnitine transport (C14:0Crn)
product: 019518
product: 019530

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species: 985450

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species: 984552

984552
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: tetradecanoylcarnitine (C14:0Crn)

019590
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value: 0.0

019578
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value: 0.0

019566
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value: 1000.0

019554
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019518
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species: 982040

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species: 986705

986705
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initial concentration: NaN
initial amount: NaN
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name: tetradecanoylcarnitine (C14:0Crn)

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: octadecatrienoate (C18:3, n-6)

064217
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kinetic law: 064255
product: 064242
reactant: 064230
notes: SUBSYSTEM: Phospholipid Metabolism
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reversible: true
name: phosphatidate reversible transport, mitochondrial, myocyte

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064279
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064267
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064242
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species: 986355

986355
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Phosphatidate, Human Myocyte

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species: 983938

072075
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kinetic law: 072123
product: 072111
product: 072099
reactant: 072087
notes: GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Tetrahydrobiopterin
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reversible: false
name: 6-pyruvoyltetrahydropterin synthase

072171
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value: 500.0

072159
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value: 0.0

072147
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value: 1000.0

072135
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value: 0.0

072111
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species: 984238

984238
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Inorganic triphosphate

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species: 981399

981399
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: 6-Pyruvoyl-5,6,7,8-tetrahydropterin

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species: 981581

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate

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name: Malate:sulfite antiport, mitochondrial
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
kinetic law: 054673
reactant: 054636
product: 054648
reversible: true
reactant: 054624
product: 054660

054721
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054709
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054697
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value: 1000.0

054685
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species: 986609

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Sulfite

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species: 984431

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Sulfite

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species: 983407

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species: 986066

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Malate

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: (R)-Mevalonate

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reactant: 077397
product: 077434
name: Succinate--CoA ligase (ADP-forming)
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reactant: 077385
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product: 077421
notes: GENE_ASSOCIATION: (NM_003849.1 and NM_003850.1) GENE_LIST: NM_003849.1 NM_003850.1 SUBSYSTEM: Citric Acid Cycle
product: 077409
reactant: 077373

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species: 986657

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Succinate

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species: 986669

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Succinyl-CoA

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value: 0.0

077482
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value: 0.0

077470
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value: 1000.0

077458
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value: -1000.0

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species: 985413

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species: 986451

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species: 985195

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species: 985279

037132
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kinetic law: 037181
product: 037168
product: 037156
reactant: 037144
notes: GENE_ASSOCIATION: (NM_005165.2 or NM_184041.1 or NM_000035.2 or NM_184043.1 or NM_000034.2) GENE_LIST: NM_000034.2 NM_000035.2 NM_005165.2 NM_184041.1 NM_184043.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: fructose-bisphosphate aldolase

037229
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value: 0.0

037217
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value: 0.0

037205
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value: 1000.0

037193
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037168
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species: 982836

982836
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Glyceraldehyde 3-phosphate

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stoichiometry: 1.0
species: 982294

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Dihydroxyacetone phosphate

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species: 982704

982704
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Fructose 1,6-bisphosphate

994541
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kinetic law: 994577
product: 994565
reactant: 994553
fast: false
reversible: true
name: Ammonium exchange

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value: 0.0

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994601
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value: 1000.0

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initial concentration: NaN
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030554
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notes: SUBSYSTEM: Fatty Acid Biosynthesis
product: 030676
product: 030626
reactant: 030614
reactant: 030566
product: 030638
name: fatty-acyl-CoA elongation (C20:4CoA, n3)
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reactant: 030590
kinetic law: 030688
reactant: 030602
reactant: 030578
reversible: false
product: 030663

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species: 983673

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species: 984528

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initial concentration: NaN
initial amount: NaN
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name: stearidonyl coenzyme A (C18:4CoA, n-3)

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030638
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030650
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initial concentration: NaN
initial amount: NaN
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name: eicosatetraenoyl-CoA (C20:4CoA, n-3)

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species: 983685

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species: 983419

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Malonyl-CoA

030663
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species: 983078

003485
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kinetic law: 003569
reactant: 003509
reactant: 003521
reactant: 003497
name: 2-oxoglutarate dehydrogenase, mitochondrial
product: 003545
product: 003533
fast: false
reversible: false
product: 003557

003617
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value: 500.0

003605
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value: 0.0

003593
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value: 1000.0

003581
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003509
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species: 985413

003521
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species: 986150

003497
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species: 985219

985219
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Oxoglutarate

003545
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species: 986162

003533
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species: 985400

003557
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species: 986669

003749
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kinetic law: 003810
reversible: true
product: 003798
name: L-alanine/glutamine reversible exchange, blood
reactant: 003761
product: 003786
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reactant: 003774
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular

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species: 981629

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species: 980046

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species: 980387

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species: 982897

064471
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kinetic law: 064508
product: 064496
reactant: 064484
notes: SUBSYSTEM: Transport, Mitochondrial
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reversible: false
name: Phosphocreatine transport to/from mitochondria via diffusion

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064547
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064534
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species: 982027

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphocreatine

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species: 985438

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Phosphocreatine

983029
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Oxidized glutathione

045879
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product: 045975
name: GMP synthase (glutamine-hydrolysing)
reactant: 045927
fast: false
kinetic law: 045999
product: 045963
reactant: 045891
reactant: 045903
product: 045951
reversible: false
reactant: 045915
product: 045939
product: 045987
notes: GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Purine Metabolism

045975
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stoichiometry: 2.0
species: 983066

045927
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species: 984817

984817
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Xanthosine 5'-phosphate

046047
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value: 500.0

046035
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value: 0.0

046023
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value: 1000.0

046011
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045963
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species: 983005

045891
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species: 981738

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982355
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Dephospho-CoA

993477
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kinetic law: 993514
product: 993501
reactant: 993489
fast: false
reversible: true
name: hexadecenoate (C16:1, n-7) exchange

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993538
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value: 1000.0

993526
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species: 987931

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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: hdcea7_b

993489
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species: 980483

980483
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: hexadecenoate (C16:1, n-7)

996563
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kinetic law: 996599
product: 996587
reactant: 996575
fast: false
reversible: true
name: tetradecenoate (C14:1, n-7) exchange

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value: 1000.0

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species: 988320

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initial concentration: NaN
initial amount: NaN
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name: ttdcea7_b

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species: 980879

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initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: tetradecenoate (C14:1, n-7)

079071
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reversible: false
product: 079131
reactant: 079095
kinetic law: 079143
product: 079119
product: 079107
reactant: 079083
name: thymidine kinase (ATP:thymidine)
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notes: GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides

079131
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species: 983066

079095
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species: 984600

984600
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Thymidine

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value: 500.0

079179
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value: 0.0

079167
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value: 1000.0

079155
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079119
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species: 982427

079107
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species: 981557

079083
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species: 981738

015352
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product: 015400
reactant: 015364
notes: GENE_ASSOCIATION: (NM_001876.2 or NM_152246.1 or NM_001031847.1 or NM_152247.1 or NM_004377.2 or NM_152359.1 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
fast: false
reactant: 015376
product: 015388
kinetic law: 015412
name: carnitine eicosatetraenoyltransferase (C20:4Crn, n6)

015400
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species: 982632

982632
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)

015364
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species: 982040

015376
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species: 982619

015388
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species: 981991

015460
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015448
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015436
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015424
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048543
type: Reaction
product: 048579
product: 048591
notes: GENE_ASSOCIATION: (NM_002115.1 or NM_033497.1 or NM_000189.4 or NM_000188.1) GENE_LIST: NM_000188.1 NM_000189.4 NM_002115.1 NM_033497.1 SUBSYSTEM: Fructose and Mannose Metabolism
kinetic law: 048615
reactant: 048567
product: 048603
reactant: 048555
name: hexokinase (D-mannose:ATP)
fast: false
reversible: false

048579
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species: 981557

048591
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stoichiometry: 1.0
species: 983066

048663
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048651
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048639
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value: 1000.0

048627
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048567
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stoichiometry: 1.0
species: 983431

983431
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Mannose

048603
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stoichiometry: 1.0
species: 983443

983443
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Mannose 6-phosphate

048555
type: SpeciesReference
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species: 981738

069128
type: Reaction
notes: GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Anaplerotic reactions
product: 069188
reversible: false
reactant: 069140
kinetic law: 069200
reactant: 069152
product: 069164
product: 069176
fast: false
name: phosphoenolpyruvate carboxykinase (GTP)

069188
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species: 984046

984046
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphoenolpyruvate

069140
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species: 983054

069248
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value: 500.0

069236
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069224
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069212
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069152
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species: 983733

069164
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species: 981979

069176
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species: 982873

077241
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reactant: 077265
product: 077277
product: 077289
kinetic law: 077301
reversible: true
notes: GENE_ASSOCIATION: (NM_001035513.1 or NM_001035512.1 or NM_001035511.1) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 SUBSYSTEM: Oxidative Phosphorylation
reactant: 077253
name: succinate dehydrogenase cytochrome b
fast: false

077265
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stoichiometry: 1.0
species: 986741

986741
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ubiquinone-10

077277
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stoichiometry: 1.0
species: 985632

077289
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stoichiometry: 1.0
species: 986584

986584
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ubiquinol-10

077349
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value: 0.0

077337
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077325
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value: 1000.0

077313
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077253
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stoichiometry: 1.0
species: 985644

048404
type: Reaction
kinetic law: 048483
product: 048440
name: hexokinase (D-glucose:ATP)
reactant: 048428
reversible: false
fast: false
product: 048459
product: 048471
notes: GENE_ASSOCIATION: (NM_025130.2 or NM_033498.1 or NM_000162.2 or NM_000188.1 or NM_033507.1 or NM_033500.1 or NM_033508.1 or NM_033496.1 or NM_000189.4 or NM_002115.1 or NM_033497.1) GENE_LIST: NM_000162.2 NM_000188.1 NM_000189.4 NM_002115.1 NM_025130.2 NM_033496.1 NM_033497.1 NM_033498.1 NM_033500.1 NM_033507.1 NM_033508.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 048416

048531
type: LocalParameter
value: 500.0

048519
type: LocalParameter
value: 0.0

048507
type: LocalParameter
value: 1000.0

048495
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value: 0.0

048440
type: SpeciesReference
stoichiometry: 1.0
species: 981557

048428
type: SpeciesReference
stoichiometry: 1.0
species: 982885

982885
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Glucose

048459
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stoichiometry: 1.0
species: 982849

982849
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Glucose 6-phosphate

048471
type: SpeciesReference
stoichiometry: 1.0
species: 983066

048416
type: SpeciesReference
stoichiometry: 1.0
species: 981738

028610
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fast: false
product: 028659
reactant: 028635
kinetic law: 028695
reactant: 028622
notes: GENE_ASSOCIATION: (NM_004457.3 or NM_203372.1 or NM_022977.1 or NM_203379.1 or NM_015256.2 or NM_004458.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reversible: true
reactant: 028647
product: 028683
product: 028671
name: fatty-acid--CoA ligase (heptadecanoate, C17:0)

028659
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stoichiometry: 1.0
species: 981666

028635
type: SpeciesReference
stoichiometry: 1.0
species: 981991

028743
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value: 0.0

028731
type: LocalParameter
value: 0.0

028719
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value: 1000.0

028707
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value: -1000.0

028622
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stoichiometry: 1.0
species: 981738

028647
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stoichiometry: 1.0
species: 983234

028683
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species: 984202

028671
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stoichiometry: 1.0
species: 983247

983247
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: heptadecanoyl CoA (C17:0CoA)

986887
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Cholesterol

991920
type: Reaction
kinetic law: 991957
product: 991945
reactant: 991932
fast: false
reversible: true
name: eicosatrienoate (C20:3,n-9) exchange

992005
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value: 500.0

991993
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value: 0.0

991981
type: LocalParameter
value: 1000.0

991969
type: LocalParameter
value: 0.0

991945
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stoichiometry: 1.0
species: 987738

987738
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecstea9_b

991932
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stoichiometry: 1.0
species: 980289

980289
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: eicosatrienoate (C20:3,n-9)

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Aspartate

050268
type: Reaction
fast: false
notes: GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Phenylalanine metabolism
product: 050304
kinetic law: 050328
reversible: false
name: 4-hydroxyphenylpyruvate dioxygenase
reactant: 050292
product: 050316
reactant: 050280

050304
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species: 981051

981051
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Hydroxyphenylacetate

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value: 500.0

050364
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value: 0.0

050352
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value: 1000.0

050340
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value: 0.0

050292
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species: 984082

984082
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phenylpyruvate

050316
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species: 981979

050280
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stoichiometry: 1.0
species: 983709

037603
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fast: false
product: 037652
reactant: 037628
notes: GENE_ASSOCIATION: (NM_000617.1 or NM_000578.2 or NM_014585.3) GENE_LIST: NM_000578.2 NM_000617.1 NM_014585.3 SUBSYSTEM: Transport, Extracellular
name: iron (II) transport, blood
reversible: true
reactant: 037615
product: 037640
kinetic law: 037664

037652
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stoichiometry: 1.0
species: 982716

982716
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Fe2+

037628
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species: 983066

037615
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stoichiometry: 1.0
species: 980338

980338
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Fe2+

037640
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species: 980435

037712
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037700
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value: 0.0

037688
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value: 1000.0

037676
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006163
type: Reaction
fast: false
name: arginine decarboxylase (m)
reactant: 006187
kinetic law: 006223
reactant: 006175
product: 006199
notes: GENE_ASSOCIATION: NM_052998.2 GENE_LIST: NM_052998.2 SUBSYSTEM: Arginine and Proline Metabolism
product: 006211
reversible: false

006187
type: SpeciesReference
stoichiometry: 1.0
species: 985836

006271
type: LocalParameter
value: 500.0

006259
type: LocalParameter
value: 0.0

006247
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value: 1000.0

006235
type: LocalParameter
value: 0.0

006175
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species: 985255

985255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Arginine

006199
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stoichiometry: 1.0
species: 985207

985207
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Agmatine

006211
type: SpeciesReference
stoichiometry: 1.0
species: 985400

081545
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notes: GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine degradation
product: 081581
kinetic law: 081606
fast: false
reactant: 081557
reversible: true
reactant: 081569
product: 081594
name: valine transaminase

081581
type: SpeciesReference
stoichiometry: 1.0
species: 981159

981159
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Methyl-2-oxobutanoate

081654
type: LocalParameter
value: 0.0

081642
type: LocalParameter
value: 0.0

081630
type: LocalParameter
value: 1000.0

081618
type: LocalParameter
value: -1000.0

081557
type: SpeciesReference
stoichiometry: 1.0
species: 981617

081569
type: SpeciesReference
stoichiometry: 1.0
species: 984805

081594
type: SpeciesReference
stoichiometry: 1.0
species: 982909

063447
type: Reaction
reactant: 063459
kinetic law: 063507
notes: GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
product: 063495
reversible: true
fast: false
reactant: 063471
product: 063483
name: ornithine transport, mitochondrial

063459
type: SpeciesReference
stoichiometry: 1.0
species: 983890

983890
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Ornithine

063555
type: LocalParameter
value: 0.0

063543
type: LocalParameter
value: 0.0

063531
type: LocalParameter
value: 1000.0

063519
type: LocalParameter
value: -1000.0

063495
type: SpeciesReference
stoichiometry: 1.0
species: 986343

986343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Ornithine

063471
type: SpeciesReference
stoichiometry: 1.0
species: 985836

063483
type: SpeciesReference
stoichiometry: 1.0
species: 983066

003991
type: Reaction
fast: false
name: L-alanine/L-serine exchange, blood
product: 004039
reactant: 004015
kinetic law: 004052
product: 004027
reactant: 004003
reversible: true
notes: GENE_ASSOCIATION: (NM_005628.1 or NM_003038.2) GENE_LIST: NM_003038.2 NM_005628.1 SUBSYSTEM: Transport, Extracellular

004039
type: SpeciesReference
stoichiometry: 1.0
species: 981629

004015
type: SpeciesReference
stoichiometry: 1.0
species: 984418

004100
type: LocalParameter
value: 0.0

004088
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value: 0.0

004076
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value: 1000.0

004064
type: LocalParameter
value: -1000.0

004027
type: SpeciesReference
stoichiometry: 1.0
species: 980818

004003
type: SpeciesReference
stoichiometry: 1.0
species: 980046

984382
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sedoheptulose 7-phosphate

011159
type: Reaction
product: 011211
fast: false
reactant: 011185
reversible: false
notes: SUBSYSTEM: Sphingomyelin
reactant: 011172
product: 011198
name: Ceramide cholinephosphotransferase, human myocyte
kinetic law: 011224

011211
type: SpeciesReference
stoichiometry: 0.001
species: 984455

011185
type: SpeciesReference
stoichiometry: 0.001
species: 981822

981822
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: ceramide, Human Myocyte

011172
type: SpeciesReference
stoichiometry: 1.0
species: 981798

981798
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CDPcholine

011198
type: SpeciesReference
stoichiometry: 1.0
species: 981967

981967
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: CMP

011275
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value: 500.0

011263
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value: 0.0

011250
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value: 1000.0

011237
type: LocalParameter
value: 0.0

037724
type: Reaction
kinetic law: 037761
product: 037749
reactant: 037737
notes: GENE_ASSOCIATION: (NM_016612.2 or NM_031212.2) GENE_LIST: NM_016612.2 NM_031212.2 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: iron (II) transport

037810
type: LocalParameter
value: 0.0

037797
type: LocalParameter
value: 0.0

037785
type: LocalParameter
value: 1000.0

037773
type: LocalParameter
value: -1000.0

037749
type: SpeciesReference
stoichiometry: 1.0
species: 985668

985668
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Fe2+

037737
type: SpeciesReference
stoichiometry: 1.0
species: 982716

981484
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Acetaldehyde

987533
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: asp_L_b

012073
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_019112.2 or NM_005502.2 or NM_001606.3 or NM_212533.1 or NM_080283.3) GENE_LIST: NM_001606.3 NM_005502.2 NM_019112.2 NM_080283.3 NM_212533.1 SUBSYSTEM: Transport, Extracellular
product: 012146
reactant: 012098
product: 012158
product: 012134
product: 012122
reversible: false
reactant: 012110
kinetic law: 012170
reactant: 012086
name: cholesterol efflux (ATP depedent), blood

012146
type: SpeciesReference
stoichiometry: 1.0
species: 983066

012098
type: SpeciesReference
stoichiometry: 1.0
species: 981907

012158
type: SpeciesReference
stoichiometry: 1.0
species: 984094

012134
type: SpeciesReference
stoichiometry: 1.0
species: 981557

012122
type: SpeciesReference
stoichiometry: 1.0
species: 980119

980119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Cholesterol

012110
type: SpeciesReference
stoichiometry: 1.0
species: 983078

012221
type: LocalParameter
value: 500.0

012208
type: LocalParameter
value: 0.0

012195
type: LocalParameter
value: 1000.0

012182
type: LocalParameter
value: 0.0

012086
type: SpeciesReference
stoichiometry: 1.0
species: 981738

988345
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: urea_b

007564
type: Reaction
product: 007612
product: 007624
name: aspartate carbamoyltransferase (reversible)
reversible: true
reactant: 007576
reactant: 007588
kinetic law: 007636
fast: false
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Metabolism
product: 007600

007612
type: SpeciesReference
stoichiometry: 1.0
species: 983066

007624
type: SpeciesReference
stoichiometry: 1.0
species: 984094

007576
type: SpeciesReference
stoichiometry: 1.0
species: 981726

007588
type: SpeciesReference
stoichiometry: 1.0
species: 981774

981774
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Carbamoyl phosphate

007684
type: LocalParameter
value: 0.0

007672
type: LocalParameter
value: 0.0

007660
type: LocalParameter
value: 1000.0

007648
type: LocalParameter
value: -1000.0

007600
type: SpeciesReference
stoichiometry: 1.0
species: 981762

981762
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N-Carbamoyl-L-aspartate

988211
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: pnto_R_b

080170
type: Reaction
kinetic law: 080206
product: 080194
reactant: 080182
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Tetradecanoate (n-C14:0) transport in via uniport

080254
type: LocalParameter
value: 0.0

080242
type: LocalParameter
value: 0.0

080230
type: LocalParameter
value: 1000.0

080218
type: LocalParameter
value: -1000.0

080194
type: SpeciesReference
stoichiometry: 1.0
species: 980867

980867
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: tetradecanoate (C14:0)

080182
type: SpeciesReference
stoichiometry: 1.0
species: 984684

019603
type: Reaction
product: 019651
notes: GENE_ASSOCIATION: (NM_003060.2 or NM_003059.2) GENE_LIST: NM_003059.2 NM_003060.2 SUBSYSTEM: Transport, Extracellular
fast: false
reactant: 019627
product: 019639
reactant: 019615
name: L-carnitine inward transport by Na+ symport
reversible: false
kinetic law: 019663

019651
type: SpeciesReference
stoichiometry: 1.0
species: 983637

019627
type: SpeciesReference
stoichiometry: 1.0
species: 980605

019639
type: SpeciesReference
stoichiometry: 1.0
species: 982040

019615
type: SpeciesReference
stoichiometry: 1.0
species: 980155

019713
type: LocalParameter
value: 500.0

019701
type: LocalParameter
value: 0.0

019688
type: LocalParameter
value: 1000.0

019676
type: LocalParameter
value: 0.0

984479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Spermidine

007442
type: Reaction
reactant: 007455
reversible: true
product: 007492
fast: false
kinetic law: 007504
reactant: 007467
name: L-asparagine transport in via sodium symport, blood
notes: GENE_ASSOCIATION: (NM_018976.3 or NM_001077484.1 or NM_030674.2 or NM_007231.1 or NM_018018.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
product: 007479

007455
type: SpeciesReference
stoichiometry: 1.0
species: 980071

980071
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Asparagine

007492
type: SpeciesReference
stoichiometry: 1.0
species: 983637

007552
type: LocalParameter
value: 0.0

007540
type: LocalParameter
value: 0.0

007528
type: LocalParameter
value: 1000.0

007516
type: LocalParameter
value: -1000.0

007467
type: SpeciesReference
stoichiometry: 1.0
species: 980605

007479
type: SpeciesReference
stoichiometry: 1.0
species: 981714

064316
type: Reaction
reversible: true
reactant: 064353
name: propionyl-CoA synthetase
notes: GENE_ASSOCIATION: NM_018677.2 GENE_LIST: NM_018677.2 SUBSYSTEM: Propanoate Metabolism
kinetic law: 064405
fast: false
product: 064392
product: 064366
reactant: 064341
reactant: 064328
product: 064379

064353
type: SpeciesReference
stoichiometry: 1.0
species: 984166

984166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Propionate

064458
type: LocalParameter
value: 0.0

064445
type: LocalParameter
value: 0.0

064432
type: LocalParameter
value: 1000.0

064418
type: LocalParameter
value: -1000.0

064392
type: SpeciesReference
stoichiometry: 1.0
species: 984202

064366
type: SpeciesReference
stoichiometry: 1.0
species: 981666

064341
type: SpeciesReference
stoichiometry: 1.0
species: 981991

064328
type: SpeciesReference
stoichiometry: 1.0
species: 981738

064379
type: SpeciesReference
stoichiometry: 1.0
species: 984190

984190
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Propanoyl-CoA (C3:0CoA)

985548
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: endecanoyl-CoA (C11:0CoA)

014510
type: Reaction
fast: false
reactant: 014534
reactant: 014522
reversible: true
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
product: 014558
name: docosahexaenoyl carnitine transport (C22:6Crn, n3)
product: 014546
kinetic law: 014570

014534
type: SpeciesReference
stoichiometry: 1.0
species: 985450

014522
type: SpeciesReference
stoichiometry: 1.0
species: 982379

982379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosahexaenoyl carnitine (C22:6Crn, n-3)

014558
type: SpeciesReference
stoichiometry: 1.0
species: 985511

985511
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: docosahexaenoyl carnitine (C22:6Crn, n-3)

014546
type: SpeciesReference
stoichiometry: 1.0
species: 982040

014618
type: LocalParameter
value: 0.0

014606
type: LocalParameter
value: 0.0

014594
type: LocalParameter
value: 1000.0

014582
type: LocalParameter
value: -1000.0

010056
type: Reaction
kinetic law: 010152
reactant: 010092
product: 010104
name: C-4 methyl sterol oxidase NADPH
reactant: 010080
product: 010140
product: 010128
reactant: 010068
reversible: false
notes: GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
product: 010116
fast: false

010200
type: LocalParameter
value: 500.0

010188
type: LocalParameter
value: 0.0

010176
type: LocalParameter
value: 1000.0

010164
type: LocalParameter
value: 0.0

010092
type: SpeciesReference
stoichiometry: 1.0
species: 987117

010104
type: SpeciesReference
stoichiometry: 1.0
species: 986899

986899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: CO2

010080
type: SpeciesReference
stoichiometry: 1.0
species: 987093

010140
type: SpeciesReference
stoichiometry: 1.0
species: 987217

987217
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: zymosterone

010128
type: SpeciesReference
stoichiometry: 1.0
species: 987105

010068
type: SpeciesReference
stoichiometry: 1.0
species: 986814

986814
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 4-Methylzymosterol intermediate 2

010116
type: SpeciesReference
stoichiometry: 1.0
species: 987021

057492
type: Reaction
kinetic law: 057529
product: 057517
reactant: 057505
notes: GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Anaplerotic reactions
fast: false
reversible: true
name: methylmalonyl-CoA epimerase, mitochondrial

057577
type: LocalParameter
value: 0.0

057565
type: LocalParameter
value: 0.0

057553
type: LocalParameter
value: 1000.0

057541
type: LocalParameter
value: -1000.0

057517
type: SpeciesReference
stoichiometry: 1.0
species: 986126

057505
type: SpeciesReference
stoichiometry: 1.0
species: 986138

986138
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-Methylmalonyl-CoA

981447
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Aminoacetone

998398
type: Reaction
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
kinetic law: 998458
product: 998446
notes: GENE_ASSOCIATION: (NM_020686.3 or NM_000663.2) GENE_LIST: NM_000663.2 NM_020686.3 SUBSYSTEM: Glutamate Metabolism
reversible: true
reactant: 998410
product: 998434
fast: false
reactant: 998422

998506
type: LocalParameter
value: 0.0

998494
type: LocalParameter
value: 0.0

998482
type: LocalParameter
value: 1000.0

998470
type: LocalParameter
value: -1000.0

998446
type: SpeciesReference
stoichiometry: 1.0
species: 986681

986681
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Succinic semialdehyde

998410
type: SpeciesReference
stoichiometry: 1.0
species: 985071

985071
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 4-Aminobutanoate

998434
type: SpeciesReference
stoichiometry: 1.0
species: 985752

998422
type: SpeciesReference
stoichiometry: 1.0
species: 985219

985680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ferricytochrome c

980058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Arginine

067488
type: Reaction
fast: false
reversible: true
product: 067536
kinetic law: 067548
reactant: 067500
reactant: 067512
notes: GENE_ASSOCIATION: (NM_001098486.1 or NM_006632.3 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Peroxisomal
name: phosphate transporter, endoplasmic reticulum
product: 067524

067536
type: SpeciesReference
stoichiometry: 1.0
species: 987129

067596
type: LocalParameter
value: 0.0

067584
type: LocalParameter
value: 0.0

067572
type: LocalParameter
value: 1000.0

067560
type: LocalParameter
value: -1000.0

067500
type: SpeciesReference
stoichiometry: 1.0
species: 983066

067512
type: SpeciesReference
stoichiometry: 1.0
species: 984094

067524
type: SpeciesReference
stoichiometry: 1.0
species: 987021

066241
type: Reaction
kinetic law: 066278
product: 066265
reactant: 066253
notes: GENE_ASSOCIATION: (NM_199186.1 or NM_002629.2 or NM_000290.2 or NM_001029891.2 or NM_001724.3) GENE_LIST: NM_000290.2 NM_001029891.2 NM_001724.3 NM_002629.2 NM_199186.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: phosphoglycerate mutase

066326
type: LocalParameter
value: 0.0

066314
type: LocalParameter
value: 0.0

066302
type: LocalParameter
value: 1000.0

066290
type: LocalParameter
value: -1000.0

066265
type: SpeciesReference
stoichiometry: 1.0
species: 981087

981087
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Glycerate 2-phosphate

066253
type: SpeciesReference
stoichiometry: 1.0
species: 981183

981183
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Phospho-D-glycerate

043807
type: Reaction
reversible: true
fast: false
reactant: 043819
reactant: 043832
product: 043856
notes: GENE_ASSOCIATION: (NM_206965.1 or NM_006657.2) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
product: 043844
name: glutamate formimidoyltransferase
kinetic law: 043868

043819
type: SpeciesReference
stoichiometry: 1.0
species: 981339

981339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Formiminotetrahydrofolate

043832
type: SpeciesReference
stoichiometry: 1.0
species: 982909

043856
type: SpeciesReference
stoichiometry: 1.0
species: 984576

043844
type: SpeciesReference
stoichiometry: 1.0
species: 982752

982752
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N-Formimidoyl-L-glutamate

043916
type: LocalParameter
value: 0.0

043904
type: LocalParameter
value: 0.0

043892
type: LocalParameter
value: 1000.0

043880
type: LocalParameter
value: -1000.0

018028
type: Reaction
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
product: 018065
product: 018078
reactant: 018040
reactant: 018053
name: carnitine octadecanoyltransferase (C18:0Crn), mitochondria
kinetic law: 018090

018065
type: SpeciesReference
stoichiometry: 1.0
species: 985450

018078
type: SpeciesReference
stoichiometry: 1.0
species: 986633

986633
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Stearyl-CoA (n-C18:0CoA)

018040
type: SpeciesReference
stoichiometry: 1.0
species: 985413

018053
type: SpeciesReference
stoichiometry: 1.0
species: 986645

986645
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Stearoylcarnitine (C18:0Crn)

018139
type: LocalParameter
value: 0.0

018127
type: LocalParameter
value: 0.0

018115
type: LocalParameter
value: 1000.0

018102
type: LocalParameter
value: -1000.0

980423
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Glycerol

080980
type: Reaction
kinetic law: 081028
product: 081016
reactant: 081004
reactant: 080992
notes: GENE_ASSOCIATION: NM_144639.1 GENE_LIST: NM_144639.1 SUBSYSTEM: Histidine Degradation
fast: false
reversible: false
name: urocanase

081076
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081064
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081052
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081040
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081016
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species: 981255

081004
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species: 984757

984757
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initial concentration: NaN
initial amount: NaN
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name: Urocanate

080992
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species: 983078

986030
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: D-Lactate

053211
type: Reaction
kinetic law: 053259
product: 053247
reactant: 053235
reactant: 053223
notes: GENE_ASSOCIATION: NM_006708.1 GENE_LIST: NM_006708.1 SUBSYSTEM: Pyruvate Metabolism
fast: false
reversible: false
name: lactoylglutathione lyase

053307
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053295
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053283
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053271
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053247
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species: 983383

983383
type: Species
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (R)-S-Lactoylglutathione

053235
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species: 983565

983565
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Methylglyoxal

053223
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species: 983041

983041
type: Species
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has only substance units: false
initial concentration: NaN
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in compartment: 979924
name: Reduced glutathione

018512
type: Reaction
fast: false
product: 018560
name: pentadecanoyl carnitine transport (C15:0Crn)
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reactant: 018536
reactant: 018524
product: 018548
kinetic law: 018572
reversible: true

018560
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species: 986391

986391
type: Species
constant: false
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: pentadecanoylcarnitine (C15:0Crn)

018536
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species: 985450

018524
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species: 984010

984010
type: Species
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: pentadecanoylcarnitine (C15:0Crn)

018548
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species: 982040

018620
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018608
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018596
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018584
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986717
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 5,6,7,8-Tetrahydrofolate

994445
type: Reaction
kinetic law: 994481
product: 994469
reactant: 994457
fast: false
reversible: true
name: Sodium exchange

994529
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994517
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994505
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994493
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994469
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species: 988054

988054
type: Species
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initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: na1_b

994457
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species: 980605

068514
type: Reaction
reversible: false
reactant: 068526
product: 068574
notes: SUBSYSTEM: Other
product: 068550
fast: false
kinetic law: 068586
product: 068562
reactant: 068538
name: inorganic triphosphatase

068526
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species: 983078

068574
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068550
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species: 983066

068634
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068622
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068610
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068598
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068562
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species: 984094

068538
type: SpeciesReference
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species: 984238

983334
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Kynurenine

037823
type: Reaction
kinetic law: 037897
reactant: 037835
reactant: 037848
product: 037860
product: 037872
product: 037884
reversible: false
notes: GENE_ASSOCIATION: NM_001010982.1 GENE_LIST: NM_001010982.1 SUBSYSTEM: Tryptophan metabolism
fast: false
name: N-Formyl-L-kynurenine amidohydrolase

037945
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037933
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value: 0.0

037921
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037909
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037835
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stoichiometry: 1.0
species: 981423

037848
type: SpeciesReference
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species: 983078

037860
type: SpeciesReference
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species: 982740

982740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Formate

037872
type: SpeciesReference
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species: 983066

037884
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species: 983334

013444
type: Reaction
kinetic law: 013493
product: 013481
product: 013469
reactant: 013457
notes: SUBSYSTEM: Contraction
fast: false
reversible: false
name: muscle contraction, myocyte cytosol

013542
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013530
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013518
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value: 1000.0

013506
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013481
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species: 984094

013469
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stoichiometry: 1.0
species: 983589

013457
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species: 983601

983601
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Myosin-Actin-ADP-Pi

980732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Phenylalanine

057589
type: Reaction
kinetic law: 057625
product: 057613
reactant: 057601
notes: GENE_ASSOCIATION: NM_000255.1 GENE_LIST: NM_000255.1 SUBSYSTEM: Anaplerotic reactions
fast: false
reversible: true
name: methylmalonyl-CoA mutase

057673
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057661
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057649
type: LocalParameter
value: 1000.0

057637
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057613
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species: 986669

057601
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species: 986126

981375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 6-Phospho-D-gluconate

042173
type: Reaction
kinetic law: 042209
product: 042197
reactant: 042185
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: glycerol-3-phosphate transport, mitochondrial

042258
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042246
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042233
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042221
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042197
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species: 985812

985812
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: sn-Glycerol 3-phosphate

042185
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species: 982969

982969
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: sn-Glycerol 3-phosphate

045537
type: Reaction
kinetic law: 045573
product: 045561
reactant: 045549
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: glycine passive transport to mitochondria

045621
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045609
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045597
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value: 1000.0

045585
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045561
type: SpeciesReference
stoichiometry: 1.0
species: 985800

985800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Glycine

045549
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species: 982945

980507
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: heptadecanoate (C17:0)

983150
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: hexadecenoyl-CoA (C16:1CoA, n-7)

065513
type: Reaction
name: phosphogluconate dehydrogenase
notes: GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
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reactant: 065525
fast: false
product: 065561
product: 065573
product: 065549
kinetic law: 065585
reversible: false

065537
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species: 983673

065525
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species: 981375

065561
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species: 983685

065573
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species: 984370

984370
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Ribulose 5-phosphate

065549
type: SpeciesReference
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species: 981979

065634
type: LocalParameter
value: 500.0

065621
type: LocalParameter
value: 0.0

065609
type: LocalParameter
value: 1000.0

065597
type: LocalParameter
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004112
type: Reaction
product: 004185
product: 004160
name: 5-aminolevulinate synthase
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reactant: 004148
product: 004172
notes: GENE_ASSOCIATION: (NM_001037969.1 or NM_000688.4 or NM_001037967.1 or NM_000032.2 or NM_001037968.1 or NM_199166.1) GENE_LIST: NM_000032.2 NM_000688.4 NM_001037967.1 NM_001037968.1 NM_001037969.1 NM_199166.1 SUBSYSTEM: Heme Biosynthesis
reactant: 004124
fast: false
kinetic law: 004197
reactant: 004136

004185
type: SpeciesReference
stoichiometry: 1.0
species: 985413

004160
type: SpeciesReference
stoichiometry: 1.0
species: 985096

985096
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 5-Amino-4-oxopentanoate

004148
type: SpeciesReference
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species: 986669

004172
type: SpeciesReference
stoichiometry: 1.0
species: 985400

004124
type: SpeciesReference
stoichiometry: 1.0
species: 985800

004246
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value: 500.0

004234
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value: 0.0

004221
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value: 1000.0

004209
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value: 0.0

004136
type: SpeciesReference
stoichiometry: 1.0
species: 985836

985267
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Aspartate

982113
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dADP

980978
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 1-Acyl-sn-glycerol 3-phosphate, human myocyte

986802
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 4-Methylzymosterol intermediate 1

980229
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: dodecanoate (C12:0)

065379
type: Reaction
reversible: true
fast: false
name: phosphoglycerate dehydrogenase
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product: 065416
product: 065441
notes: GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Glycine and Serine Metabolism
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reactant: 065392
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065501
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065489
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065477
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065465
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065416
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species: 981195

981195
type: Species
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initial concentration: NaN
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in compartment: 979924
name: 3-Phosphohydroxypyruvate

065441
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species: 983661

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initial concentration: NaN
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species: 983066

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species: 981183

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species: 983649

983649
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004379
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notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
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product: 004416
reactant: 004391
reversible: true

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004468
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004455
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004429
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species: 981629

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species: 984588

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species: 980843

004391
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species: 980046

015110
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reversible: true
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
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product: 015159
kinetic law: 015171
product: 015147

015123
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species: 985450

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species: 985560

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species: 985572

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015207
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015195
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015183
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015147
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species: 985413

051329
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reactant: 051341
kinetic law: 051415
fast: false
reactant: 051354
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notes: GENE_ASSOCIATION: (NM_000884.2 or NM_001102605.1 or NM_000883.2 or NM_183243.1) GENE_LIST: NM_000883.2 NM_000884.2 NM_001102605.1 NM_183243.1 SUBSYSTEM: Purine Metabolism
product: 051403
reactant: 051366
product: 051390
product: 051378
reversible: false

051341
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species: 983078

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051439
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051427
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051354
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species: 983297

051403
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species: 984817

051366
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species: 983649

051390
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species: 983661

051378
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species: 983066

022703
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product: 022836
product: 022921
product: 022860
product: 022824
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product: 022812
reactant: 022728
notes: GENE_ASSOCIATION: (NM_006133.1 or NM_139179.1) GENE_LIST: NM_006133.1 NM_139179.1 SUBSYSTEM: Phospholipid Metabolism
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kinetic law: 022933
product: 022800
product: 022764
product: 022909
product: 022752
product: 022776
fast: false
product: 022896
product: 022740
reactant: 022715
product: 022884
product: 022848
product: 022788

022872
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species: 983757

022836
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species: 983234

022921
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species: 984684

022860
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species: 983745

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species: 983138

022812
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species: 983126

022728
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species: 983078

022981
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value: 500.0

022969
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022957
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022945
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022800
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species: 983066

022764
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species: 982511

022909
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species: 984322

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species: 982210

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species: 982523

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species: 983781

022740
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species: 982198

022715
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species: 980954

980954
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 1,2-Diacylglycerol, human myocyte

022884
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species: 983769

022848
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species: 983505

022788
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species: 982535

042696
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reactant: 042732
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product: 042756
product: 042780
reactant: 042708
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notes: GENE_ASSOCIATION: (NM_001033044.1 or NM_002065.4 or NM_001033056.1) GENE_LIST: NM_001033044.1 NM_001033056.1 NM_002065.4 SUBSYSTEM: Glutamate Metabolism
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name: glutamine synthetase
product: 042768
kinetic law: 042792

042732
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species: 983697

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species: 982909

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species: 982897

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species: 984094

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species: 981738

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species: 981557

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species: 983066

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042828
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value: 0.0

042816
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value: 1000.0

042804
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985034
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 3-Methyl-2-oxobutanoate

984926
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Methylprop-2-enoyl-CoA

019361
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product: 019398
reactant: 019373
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 019410
name: carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
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reactant: 019386
kinetic law: 019422

019398
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species: 985450

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species: 985413

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species: 986693

986693
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Tetradecanoyl-CoA (n-C14:0CoA)

019386
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stoichiometry: 1.0
species: 986705

019470
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019458
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value: 0.0

019446
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value: 1000.0

019434
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013251
type: Reaction
kinetic law: 013287
product: 013275
reactant: 013263
notes: SUBSYSTEM: Transport, Mitochondrial
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reversible: true
name: CO2 transport (diffusion), mitochondrial

013336
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013324
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value: 0.0

013312
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value: 1000.0

013299
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013275
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species: 985400

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stoichiometry: 1.0
species: 981979

008543
type: Reaction
reactant: 008567
fast: false
name: ATP/ADP transport, peroxisome
reactant: 008555
notes: SUBSYSTEM: Transport, Peroxisomal
product: 008579
product: 008591
kinetic law: 008603
reversible: true

008567
type: SpeciesReference
stoichiometry: 1.0
species: 987293

987293
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: ATP

008555
type: SpeciesReference
stoichiometry: 1.0
species: 981557

008579
type: SpeciesReference
stoichiometry: 1.0
species: 981738

008591
type: SpeciesReference
stoichiometry: 1.0
species: 987281

987281
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: ADP

008652
type: LocalParameter
value: 0.0

008640
type: LocalParameter
value: 0.0

008627
type: LocalParameter
value: 1000.0

008615
type: LocalParameter
value: -1000.0

049942
type: Reaction
kinetic law: 049990
product: 049978
product: 049966
reactant: 049954
notes: GENE_ASSOCIATION: (NM_000191.2 or NM_001042406.1 or NM_019036.1) GENE_LIST: NM_000191.2 NM_001042406.1 NM_019036.1 SUBSYSTEM: Leucine degradation
fast: false
reversible: false
name: hydroxymethylglutaryl-CoA lyase, mitochondrial

050038
type: LocalParameter
value: 500.0

050026
type: LocalParameter
value: 0.0

050014
type: LocalParameter
value: 1000.0

050002
type: LocalParameter
value: 0.0

049978
type: SpeciesReference
stoichiometry: 1.0
species: 985169

049966
type: SpeciesReference
stoichiometry: 1.0
species: 985156

049954
type: SpeciesReference
stoichiometry: 1.0
species: 985921

985921
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Hydroxymethylglutaryl-CoA

007696
type: Reaction
name: aspartate transaminase
kinetic law: 007756
product: 007732
fast: false
product: 007744
reactant: 007708
reactant: 007720
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Aspartate Degradation
reversible: true

007805
type: LocalParameter
value: 0.0

007793
type: LocalParameter
value: 0.0

007780
type: LocalParameter
value: 1000.0

007768
type: LocalParameter
value: -1000.0

007732
type: SpeciesReference
stoichiometry: 1.0
species: 982909

007744
type: SpeciesReference
stoichiometry: 1.0
species: 983733

007708
type: SpeciesReference
stoichiometry: 1.0
species: 981617

007720
type: SpeciesReference
stoichiometry: 1.0
species: 981726

985120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Acetoacetyl-CoA

066893
type: Reaction
name: phenylalanine transaminase
reversible: true
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Phenylalanine metabolism
product: 066942
product: 066929
fast: false
reactant: 066905
kinetic law: 066954
reactant: 066917

066942
type: SpeciesReference
stoichiometry: 1.0
species: 984082

066929
type: SpeciesReference
stoichiometry: 1.0
species: 982909

066905
type: SpeciesReference
stoichiometry: 1.0
species: 981617

067002
type: LocalParameter
value: 0.0

066990
type: LocalParameter
value: 0.0

066978
type: LocalParameter
value: 1000.0

066966
type: LocalParameter
value: -1000.0

066917
type: SpeciesReference
stoichiometry: 1.0
species: 984058

063206
type: Reaction
product: 063242
reactant: 063218
product: 063254
reactant: 063230
kinetic law: 063266
reversible: false
fast: false
notes: GENE_ASSOCIATION: NM_002539.1 GENE_LIST: NM_002539.1 SUBSYSTEM: Arginine Metabolism
name: ornithine decarboxylase

063242
type: SpeciesReference
stoichiometry: 1.0
species: 981979

063218
type: SpeciesReference
stoichiometry: 1.0
species: 983066

063254
type: SpeciesReference
stoichiometry: 1.0
species: 984334

063230
type: SpeciesReference
stoichiometry: 1.0
species: 983890

063314
type: LocalParameter
value: 500.0

063302
type: LocalParameter
value: 0.0

063290
type: LocalParameter
value: 1000.0

063278
type: LocalParameter
value: 0.0

013809
type: Reaction
product: 013857
name: creatine kinase
reversible: true
kinetic law: 013869
product: 013845
fast: false
reactant: 013833
notes: GENE_ASSOCIATION: ((NM_001823.3 and NM_001824.2) or NM_001823.3 or NM_001824.2) GENE_LIST: NM_001823.3 NM_001824.2 SUBSYSTEM: Creatine Biosynthesis
reactant: 013821

013857
type: SpeciesReference
stoichiometry: 1.0
species: 982027

013918
type: LocalParameter
value: 0.0

013906
type: LocalParameter
value: 0.0

013894
type: LocalParameter
value: 1000.0

013881
type: LocalParameter
value: -1000.0

013845
type: SpeciesReference
stoichiometry: 1.0
species: 981557

013833
type: SpeciesReference
stoichiometry: 1.0
species: 982015

982015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Creatine

013821
type: SpeciesReference
stoichiometry: 1.0
species: 981738

071492
type: Reaction
reactant: 071516
product: 071528
notes: GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Metabolism
name: phosphatidylserine decarboxylase, human myocyte
fast: false
kinetic law: 071552
product: 071540
reversible: false
reactant: 071504

071516
type: SpeciesReference
stoichiometry: 0.001
species: 984298

071528
type: SpeciesReference
stoichiometry: 1.0
species: 981979

071601
type: LocalParameter
value: 500.0

071588
type: LocalParameter
value: 0.0

071576
type: LocalParameter
value: 1000.0

071564
type: LocalParameter
value: 0.0

071540
type: SpeciesReference
stoichiometry: 0.001
species: 984034

071504
type: SpeciesReference
stoichiometry: 1.0
species: 983066

039932
type: Reaction
notes: SUBSYSTEM: Glutamine Metabolism
name: L-glutamate 5-semialdehyde dehydratase (spontaneous) mitochondrial
fast: false
product: 039969
reactant: 039944
kinetic law: 039993
reversible: true
product: 039956
product: 039981

039969
type: SpeciesReference
stoichiometry: 1.0
species: 985836

039944
type: SpeciesReference
stoichiometry: 1.0
species: 985776

985776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Glutamate 5-semialdehyde

040043
type: LocalParameter
value: 0.0

040030
type: LocalParameter
value: 0.0

040017
type: LocalParameter
value: 1000.0

040005
type: LocalParameter
value: -1000.0

039956
type: SpeciesReference
stoichiometry: 1.0
species: 984854

984854
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 1-Pyrroline-5-carboxylate

039981
type: SpeciesReference
stoichiometry: 1.0
species: 985848

981171
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (S)-3-Methyl-2-oxopentanoate

985692
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Ferrocytochrome c

988126
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ocdctra6_b

984491
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Sulfinylpyruvate

983481
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5,10-Methenyltetrahydrofolate

050906
type: Reaction
kinetic law: 050967
reactant: 050931
product: 050943
fast: false
name: isoleucine transaminase, mitochondrial
product: 050955
reactant: 050918
notes: GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Isoleucine degradation
reversible: true

051015
type: LocalParameter
value: 0.0

051003
type: LocalParameter
value: 0.0

050991
type: LocalParameter
value: 1000.0

050979
type: LocalParameter
value: -1000.0

050931
type: SpeciesReference
stoichiometry: 1.0
species: 986006

986006
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Isoleucine

050943
type: SpeciesReference
stoichiometry: 1.0
species: 985046

985046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-Methyl-2-oxopentanoate

050955
type: SpeciesReference
stoichiometry: 1.0
species: 985752

050918
type: SpeciesReference
stoichiometry: 1.0
species: 985219

981593
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

986186
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Nicotinamide adenine dinucleotide phosphate - reduced

001490
type: Reaction
kinetic law: 001538
product: 001526
reactant: 001514
reactant: 001502
notes: GENE_ASSOCIATION: (NM_001005353.1 or NM_001625.2 or NM_013410.2 or NM_203464.1 or NM_013411.3) GENE_LIST: NM_001005353.1 NM_001625.2 NM_013410.2 NM_013411.3 NM_203464.1 SUBSYSTEM: Energy Metabolism
fast: false
reversible: true
name: adenylate kinase, mitochondrial

001587
type: LocalParameter
value: 0.0

001574
type: LocalParameter
value: 0.0

001562
type: LocalParameter
value: 1000.0

001550
type: LocalParameter
value: -1000.0

001526
type: SpeciesReference
stoichiometry: 2.0
species: 985195

001514
type: SpeciesReference
stoichiometry: 1.0
species: 985279

001502
type: SpeciesReference
stoichiometry: 1.0
species: 985231

985231
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: AMP

015717
type: Reaction
kinetic law: 015777
name: carnitine eicosatrienoyltransferase (C20:3Crn, n6)
product: 015765
reactant: 015741
reactant: 015729
fast: false
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152247.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 015753
reversible: true

015826
type: LocalParameter
value: 0.0

015813
type: LocalParameter
value: 0.0

015801
type: LocalParameter
value: 1000.0

015789
type: LocalParameter
value: -1000.0

015765
type: SpeciesReference
stoichiometry: 1.0
species: 982583

982583
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosatrienoyl carnitine (C20:3Crn, n-6)

015741
type: SpeciesReference
stoichiometry: 1.0
species: 982571

015729
type: SpeciesReference
stoichiometry: 1.0
species: 982040

015753
type: SpeciesReference
stoichiometry: 1.0
species: 981991

051668
type: Reaction
kinetic law: 051717
product: 051705
reactant: 051693
reactant: 051680
notes: GENE_ASSOCIATION: NM_152435.1 GENE_LIST: NM_152435.1 SUBSYSTEM: Histidine Degradation
fast: false
reversible: false
name: imidazolonepropionase

051766
type: LocalParameter
value: 500.0

051753
type: LocalParameter
value: 0.0

051741
type: LocalParameter
value: 1000.0

051729
type: LocalParameter
value: 0.0

051705
type: SpeciesReference
stoichiometry: 1.0
species: 982752

051693
type: SpeciesReference
stoichiometry: 1.0
species: 983078

051680
type: SpeciesReference
stoichiometry: 1.0
species: 981255

020184
type: Reaction
fast: false
reactant: 020208
name: carnitine O-acetyltransferase
product: 020232
product: 020220
notes: SUBSYSTEM: Carnitine Shuttle
kinetic law: 020244
reactant: 020196
reversible: true

020208
type: SpeciesReference
stoichiometry: 1.0
species: 982040

020232
type: SpeciesReference
stoichiometry: 1.0
species: 981991

020220
type: SpeciesReference
stoichiometry: 1.0
species: 981521

981521
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: O-Acetylcarnitine

020293
type: LocalParameter
value: 0.0

020281
type: LocalParameter
value: 0.0

020269
type: LocalParameter
value: 1000.0

020257
type: LocalParameter
value: -1000.0

020196
type: SpeciesReference
stoichiometry: 1.0
species: 981496

981496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Acetyl-CoA

987057
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Lathosterol

980447
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: H2O

032314
type: Reaction
reactant: 032339
product: 032400
reversible: false
product: 032424
reactant: 032327
reactant: 032375
reactant: 032363
reactant: 032351
name: Beta oxidation of long chain fatty acid
kinetic law: 032448
product: 032412
product: 032436
product: 032387
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2... GENE_LIST: NM_000016.2 NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004092.2... NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
fast: false

032339
type: SpeciesReference
stoichiometry: 1.0
species: 985632

032400
type: SpeciesReference
stoichiometry: 1.0
species: 985644

032424
type: SpeciesReference
stoichiometry: 1.0
species: 986162

032327
type: SpeciesReference
stoichiometry: 1.0
species: 985413

032375
type: SpeciesReference
stoichiometry: 1.0
species: 986463

032363
type: SpeciesReference
stoichiometry: 1.0
species: 986150

032351
type: SpeciesReference
stoichiometry: 1.0
species: 985848

032496
type: LocalParameter
value: 500.0

032484
type: LocalParameter
value: 0.0

032472
type: LocalParameter
value: 1000.0

032460
type: LocalParameter
value: 0.0

032412
type: SpeciesReference
stoichiometry: 1.0
species: 985836

032436
type: SpeciesReference
stoichiometry: 1.0
species: 986693

032387
type: SpeciesReference
stoichiometry: 1.0
species: 985169

014268
type: Reaction
product: 014318
reversible: true
fast: false
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_152247.1 or NM_001031847.1 or NM_004377.2 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine docosahexaenoyltransferase (C22:6Crn, n3)
kinetic law: 014330
reactant: 014281
product: 014306
reactant: 014294

014318
type: SpeciesReference
stoichiometry: 1.0
species: 982379

014378
type: LocalParameter
value: 0.0

014366
type: LocalParameter
value: 0.0

014354
type: LocalParameter
value: 1000.0

014342
type: LocalParameter
value: -1000.0

014281
type: SpeciesReference
stoichiometry: 1.0
species: 982040

014306
type: SpeciesReference
stoichiometry: 1.0
species: 981991

014294
type: SpeciesReference
stoichiometry: 1.0
species: 982367

982367
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: docosahexaenoyl-CoA (C22:6CoA, n-3)

991144
type: Reaction
kinetic law: 991181
product: 991168
reactant: 991156
fast: false
reversible: true
name: docosahexaenoate (C22:6, n-3) exchange

991229
type: LocalParameter
value: 500.0

991217
type: LocalParameter
value: 0.0

991205
type: LocalParameter
value: 1000.0

991193
type: LocalParameter
value: 0.0

991168
type: SpeciesReference
stoichiometry: 1.0
species: 987641

987641
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: dcshea3_b

991156
type: SpeciesReference
stoichiometry: 1.0
species: 980192

980192
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: docosahexaenoate (C22:6, n-3)

039320
type: Reaction
kinetic law: 039372
product: 039359
reactant: 039346
reactant: 039333
notes: GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citric Acid Cycle
fast: false
reversible: true
name: fumarase, mitochondrial

039425
type: LocalParameter
value: 0.0

039413
type: LocalParameter
value: 0.0

039399
type: LocalParameter
value: 1000.0

039386
type: LocalParameter
value: -1000.0

039359
type: SpeciesReference
stoichiometry: 1.0
species: 986066

039346
type: SpeciesReference
stoichiometry: 1.0
species: 985848

039333
type: SpeciesReference
stoichiometry: 1.0
species: 985716

985716
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Fumarate

986863
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: (S)-Squalene-2,3-epoxide

058981
type: Reaction
reversible: false
product: 059020
fast: false
reactant: 059007
product: 059032
kinetic law: 059044
name: mysosin ATP binding, myocyte cytosol
reactant: 058994
notes: SUBSYSTEM: Contraction

059020
type: SpeciesReference
stoichiometry: 1.0
species: 981533

981533
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Actin

059007
type: SpeciesReference
stoichiometry: 1.0
species: 983577

983577
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Myosin-Actin

059032
type: SpeciesReference
stoichiometry: 1.0
species: 983625

983625
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Myosin-ATP

059092
type: LocalParameter
value: 500.0

059080
type: LocalParameter
value: 0.0

059068
type: LocalParameter
value: 1000.0

059056
type: LocalParameter
value: 0.0

058994
type: SpeciesReference
stoichiometry: 1.0
species: 981738

016561
type: Reaction
reversible: true
reactant: 016573
product: 016609
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 016597
reactant: 016585
kinetic law: 016621
fast: false
name: carnitine pentadecanoyltransferase (C17:0CoA), mitochondrial

016573
type: SpeciesReference
stoichiometry: 1.0
species: 985450

016609
type: SpeciesReference
stoichiometry: 1.0
species: 985957

985957
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: heptadecanoyl carnitine (C17:0Crn)

016597
type: SpeciesReference
stoichiometry: 1.0
species: 985413

016585
type: SpeciesReference
stoichiometry: 1.0
species: 985945

016670
type: LocalParameter
value: 0.0

016658
type: LocalParameter
value: 0.0

016646
type: LocalParameter
value: 1000.0

016633
type: LocalParameter
value: -1000.0

029188
type: Reaction
product: 029250
product: 029262
product: 029237
kinetic law: 029274
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_203372.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
name: fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte
reactant: 029225
reversible: true
reactant: 029201
reactant: 029213
fast: false

029250
type: SpeciesReference
stoichiometry: 1.0
species: 983829

029262
type: SpeciesReference
stoichiometry: 1.0
species: 984202

029237
type: SpeciesReference
stoichiometry: 1.0
species: 981666

029323
type: LocalParameter
value: 0.0

029311
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value: 0.0

029299
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value: 1000.0

029286
type: LocalParameter
value: -1000.0

029225
type: SpeciesReference
stoichiometry: 1.0
species: 983769

029201
type: SpeciesReference
stoichiometry: 1.0
species: 981738

029213
type: SpeciesReference
stoichiometry: 1.0
species: 981991

983210
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Hydroxymethylbilane

053741
type: Reaction
kinetic law: 053777
product: 053765
reactant: 053753
notes: GENE_ASSOCIATION: (NM_001008539.1 or NM_003045.3 or NM_018018.2 or NM_003046.2 or NM_001048164.1 or NM_032803.3) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_003045.3 NM_003046.2 NM_018018.2 NM_032803.3 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-lysine transport via diffusion, blood

053825
type: LocalParameter
value: 0.0

053813
type: LocalParameter
value: 0.0

053801
type: LocalParameter
value: 1000.0

053789
type: LocalParameter
value: -1000.0

053765
type: SpeciesReference
stoichiometry: 1.0
species: 983395

053753
type: SpeciesReference
stoichiometry: 1.0
species: 980569

980569
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Lysine

075371
type: Reaction
notes: SUBSYSTEM: Transport, Extracellular
product: 075407
kinetic law: 075431
name: sulfate sodium symport, blood
fast: false
product: 075419
reactant: 075395
reversible: true
reactant: 075383

075407
type: SpeciesReference
stoichiometry: 1.0
species: 983637

075479
type: LocalParameter
value: 0.0

075467
type: LocalParameter
value: 0.0

075455
type: LocalParameter
value: 1000.0

075443
type: LocalParameter
value: -1000.0

075419
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stoichiometry: 1.0
species: 984431

075395
type: SpeciesReference
stoichiometry: 1.0
species: 980831

980831
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Sulfite

075383
type: SpeciesReference
stoichiometry: 1.0
species: 980605

076266
type: Reaction
product: 076338
kinetic law: 076362
name: Squalene epoxidase, endoplasmic reticular
product: 076350
reactant: 076314
reactant: 076278
fast: false
reactant: 076302
reactant: 076290
notes: GENE_ASSOCIATION: NM_003129.3 GENE_LIST: NM_003129.3 SUBSYSTEM: Cholesterol Metabolism
reversible: false
product: 076326

076338
type: SpeciesReference
stoichiometry: 1.0
species: 987033

076411
type: LocalParameter
value: 500.0

076398
type: LocalParameter
value: 0.0

076386
type: LocalParameter
value: 1000.0

076374
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value: 0.0

076350
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stoichiometry: 1.0
species: 987093

076314
type: SpeciesReference
stoichiometry: 1.0
species: 987191

987191
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Squalene

076278
type: SpeciesReference
stoichiometry: 1.0
species: 987021

076302
type: SpeciesReference
stoichiometry: 1.0
species: 987117

076290
type: SpeciesReference
stoichiometry: 1.0
species: 987105

076326
type: SpeciesReference
stoichiometry: 1.0
species: 986863

054853
type: Reaction
kinetic law: 054889
product: 054877
reactant: 054865
notes: GENE_ASSOCIATION: NM_002435.1 GENE_LIST: NM_002435.1 SUBSYSTEM: Fructose and Mannose Metabolism
fast: false
reversible: true
name: mannose-6-phosphate isomerase

054937
type: LocalParameter
value: 0.0

054925
type: LocalParameter
value: 0.0

054913
type: LocalParameter
value: 1000.0

054901
type: LocalParameter
value: -1000.0

054877
type: SpeciesReference
stoichiometry: 1.0
species: 982656

054865
type: SpeciesReference
stoichiometry: 1.0
species: 983443

980532
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: D-Lactate

036409
type: Reaction
reactant: 036445
reactant: 036457
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 036433
product: 036505
name: fatty acid synthase (n-C16:0)
product: 036481
kinetic law: 036529
fast: false
product: 036517
reactant: 036421
product: 036493
product: 036469
reversible: false

036445
type: SpeciesReference
stoichiometry: 2.0
species: 983685

036457
type: SpeciesReference
stoichiometry: 1.0
species: 984684

036433
type: SpeciesReference
stoichiometry: 1.0
species: 983419

036505
type: SpeciesReference
stoichiometry: 1.0
species: 983126

036481
type: SpeciesReference
stoichiometry: 1.0
species: 981991

036578
type: LocalParameter
value: 500.0

036565
type: LocalParameter
value: 0.0

036553
type: LocalParameter
value: 1000.0

036541
type: LocalParameter
value: 0.0

036517
type: SpeciesReference
stoichiometry: 2.0
species: 983673

036421
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stoichiometry: 3.0
species: 983066

036493
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stoichiometry: 1.0
species: 983078

036469
type: SpeciesReference
stoichiometry: 1.0
species: 981979

987762
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecsttea6_b

986439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Protoheme

994348
type: Reaction
kinetic law: 994384
product: 994372
reactant: 994360
fast: false
reversible: true
name: L-Methionine exchange

994433
type: LocalParameter
value: -0.00193856

994421
type: LocalParameter
value: 0.0

994409
type: LocalParameter
value: 0.0

994396
type: LocalParameter
value: -0.00387712

994372
type: SpeciesReference
stoichiometry: 1.0
species: 988042

988042
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: met_L_b

994360
type: SpeciesReference
stoichiometry: 1.0
species: 980593

068886
type: Reaction
reactant: 068899
name: porphobilinogen synthase
product: 068923
reversible: false
fast: false
kinetic law: 068947
product: 068935
product: 068911
notes: GENE_ASSOCIATION: (NM_000031.4 or NM_001003945.1) GENE_LIST: NM_000031.4 NM_001003945.1 SUBSYSTEM: Heme Biosynthesis

068899
type: SpeciesReference
stoichiometry: 2.0
species: 981327

068923
type: SpeciesReference
stoichiometry: 2.0
species: 983078

068996
type: LocalParameter
value: 500.0

068984
type: LocalParameter
value: 0.0

068972
type: LocalParameter
value: 1000.0

068959
type: LocalParameter
value: 0.0

068935
type: SpeciesReference
stoichiometry: 1.0
species: 984178

984178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Porphobilinogen

068911
type: SpeciesReference
stoichiometry: 1.0
species: 983066

043650
type: Reaction
reactant: 043687
product: 043735
fast: false
notes: GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Anaplerotic reactions
reactant: 043662
reactant: 043675
reversible: true
kinetic law: 043747
product: 043723
product: 043711
product: 043699
name: glutamate dehydrogenase (NADP), mitochondrial

043687
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stoichiometry: 1.0
species: 986174

986174
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Nicotinamide adenine dinucleotide phosphate

043735
type: SpeciesReference
stoichiometry: 1.0
species: 986198

043662
type: SpeciesReference
stoichiometry: 1.0
species: 985752

043675
type: SpeciesReference
stoichiometry: 1.0
species: 985848

043795
type: LocalParameter
value: 0.0

043783
type: LocalParameter
value: 0.0

043771
type: LocalParameter
value: 1000.0

043759
type: LocalParameter
value: -1000.0

043723
type: SpeciesReference
stoichiometry: 1.0
species: 986186

043711
type: SpeciesReference
stoichiometry: 1.0
species: 985836

043699
type: SpeciesReference
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species: 985219

994057
type: Reaction
kinetic law: 994094
product: 994082
reactant: 994070
fast: false
reversible: true
name: L-Leucine exchange

994142
type: LocalParameter
value: -0.00422592

994130
type: LocalParameter
value: 0.0

994118
type: LocalParameter
value: 0.0

994106
type: LocalParameter
value: -0.00845184

994082
type: SpeciesReference
stoichiometry: 1.0
species: 988005

988005
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: leu_L_b

994070
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stoichiometry: 1.0
species: 980556

980556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Leucine

077891
type: Reaction
reactant: 077927
name: NAD(P) transhydrogenase
reactant: 077903
notes: GENE_ASSOCIATION: (NM_182977.1 or NM_012343.2) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: Other
reversible: false
product: 077963
product: 077939
product: 077951
reactant: 077915
fast: false
kinetic law: 077975

077927
type: SpeciesReference
stoichiometry: 1.0
species: 986174

077903
type: SpeciesReference
stoichiometry: 1.0
species: 983066

077963
type: SpeciesReference
stoichiometry: 1.0
species: 986186

077939
type: SpeciesReference
stoichiometry: 1.0
species: 985836

077951
type: SpeciesReference
stoichiometry: 1.0
species: 986150

077915
type: SpeciesReference
stoichiometry: 1.0
species: 986162

078023
type: LocalParameter
value: 500.0

078011
type: LocalParameter
value: 0.0

077999
type: LocalParameter
value: 1000.0

077987
type: LocalParameter
value: 0.0

036591
type: Reaction
reactant: 036628
product: 036700
reactant: 036603
product: 036652
reversible: false
fast: false
reactant: 036616
reactant: 036640
product: 036688
product: 036664
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
kinetic law: 036712
product: 036676
name: fatty acid synthase (C17:0), cytosol

036628
type: SpeciesReference
stoichiometry: 2.0
species: 983685

036700
type: SpeciesReference
stoichiometry: 2.0
species: 983673

036603
type: SpeciesReference
stoichiometry: 3.0
species: 983066

036652
type: SpeciesReference
stoichiometry: 1.0
species: 981979

036616
type: SpeciesReference
stoichiometry: 1.0
species: 983419

036640
type: SpeciesReference
stoichiometry: 1.0
species: 984322

036688
type: SpeciesReference
stoichiometry: 1.0
species: 983234

036664
type: SpeciesReference
stoichiometry: 1.0
species: 981991

036760
type: LocalParameter
value: 500.0

036748
type: LocalParameter
value: 0.0

036736
type: LocalParameter
value: 1000.0

036724
type: LocalParameter
value: 0.0

036676
type: SpeciesReference
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species: 983078

038562
type: Reaction
kinetic law: 038598
product: 038586
reactant: 038574
notes: GENE_ASSOCIATION: (NM_153449.2 or NM_001024939.1 or NM_030807.2 or NM_207420.1 or NM_003039.1 or NM_001024938.1) GENE_LIST: NM_001024938.1 NM_001024939.1 NM_003039.1 NM_030807.2 NM_153449.2 NM_207420.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fructose transport (uniport: facilitated diffusion)

038647
type: LocalParameter
value: 0.0

038635
type: LocalParameter
value: 0.0

038623
type: LocalParameter
value: 1000.0

038610
type: LocalParameter
value: -1000.0

038586
type: SpeciesReference
stoichiometry: 1.0
species: 982800

038574
type: SpeciesReference
stoichiometry: 1.0
species: 980350

980350
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: D-Fructose

067367
type: Reaction
name: phosphate transport in/out via proton symporter
kinetic law: 067428
reactant: 067379
reactant: 067391
product: 067416
fast: false
notes: GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
reversible: true
product: 067403

067476
type: LocalParameter
value: 0.0

067464
type: LocalParameter
value: 0.0

067452
type: LocalParameter
value: 1000.0

067440
type: LocalParameter
value: -1000.0

067379
type: SpeciesReference
stoichiometry: 1.0
species: 980435

067391
type: SpeciesReference
stoichiometry: 1.0
species: 980758

980758
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Phosphate

067416
type: SpeciesReference
stoichiometry: 1.0
species: 984094

067403
type: SpeciesReference
stoichiometry: 1.0
species: 983066

995408
type: Reaction
kinetic law: 995444
product: 995432
reactant: 995420
fast: false
reversible: true
name: L-Phenylalanine exchange

995492
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value: -0.00269568

995480
type: LocalParameter
value: 0.0

995468
type: LocalParameter
value: 0.0

995456
type: LocalParameter
value: -0.00539136

995432
type: SpeciesReference
stoichiometry: 1.0
species: 988174

988174
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: phe_L_b

995420
type: SpeciesReference
stoichiometry: 1.0
species: 980732

048210
type: Reaction
kinetic law: 048247
product: 048234
reactant: 048222
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecanoate (C16:0) transport

048295
type: LocalParameter
value: 0.0

048283
type: LocalParameter
value: 0.0

048271
type: LocalParameter
value: 1000.0

048259
type: LocalParameter
value: -1000.0

048234
type: SpeciesReference
stoichiometry: 1.0
species: 980471

980471
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: hexadecanoate (n-C16:0)

048222
type: SpeciesReference
stoichiometry: 1.0
species: 983126

993285
type: Reaction
kinetic law: 993321
product: 993309
reactant: 993297
fast: false
reversible: true
name: Bicarbonate exchange

993369
type: LocalParameter
value: 500.0

993357
type: LocalParameter
value: 0.0

993345
type: LocalParameter
value: 1000.0

993333
type: LocalParameter
value: 0.0

993309
type: SpeciesReference
stoichiometry: 1.0
species: 987907

993297
type: SpeciesReference
stoichiometry: 1.0
species: 980459

980459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Bicarbonate

011022
type: Reaction
reversible: false
reactant: 011059
reactant: 011035
name: Ceramide cholinephosphotransferase, human myocyte
product: 011071
product: 011083
kinetic law: 011096
fast: false
notes: GENE_ASSOCIATION: (NM_152621.4 or NM_147156.3) GENE_LIST: NM_147156.3 NM_152621.4 SUBSYSTEM: Sphingolipid Metabolism
reactant: 011047

011059
type: SpeciesReference
stoichiometry: 0.001
species: 983974

011035
type: SpeciesReference
stoichiometry: 0.001
species: 981822

011071
type: SpeciesReference
stoichiometry: 0.001
species: 980954

011083
type: SpeciesReference
stoichiometry: 0.001
species: 984455

011146
type: LocalParameter
value: 500.0

011133
type: LocalParameter
value: 0.0

011120
type: LocalParameter
value: 1000.0

011108
type: LocalParameter
value: 0.0

011047
type: SpeciesReference
stoichiometry: 1.0
species: 983066

075611
type: Reaction
reactant: 075624
product: 075660
reactant: 075636
fast: false
reversible: false
kinetic law: 075672
name: superoxide dismutase, mitochondrial
product: 075648
notes: GENE_ASSOCIATION: (NM_001024465.1 or NM_001024466.1 or NM_000636.2) GENE_LIST: NM_000636.2 NM_001024465.1 NM_001024466.1 SUBSYSTEM: ROS Detoxification

075624
type: SpeciesReference
stoichiometry: 2.0
species: 985836

075660
type: SpeciesReference
stoichiometry: 1.0
species: 986222

986222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: O2

075636
type: SpeciesReference
stoichiometry: 2.0
species: 986234

986234
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Superoxide

075721
type: LocalParameter
value: 500.0

075709
type: LocalParameter
value: 0.0

075696
type: LocalParameter
value: 1000.0

075684
type: LocalParameter
value: 0.0

075648
type: SpeciesReference
stoichiometry: 1.0
species: 985861

985861
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Hydrogen peroxide

982728
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide

031722
type: Reaction
reactant: 031748
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
name: Beta oxidation of odd chain fatty acid
product: 031852
reactant: 031735
product: 031826
reactant: 031787
product: 031813
kinetic law: 031865
reactant: 031774
reactant: 031761
product: 031800
reversible: false
fast: false
product: 031839

031748
type: SpeciesReference
stoichiometry: 1.0
species: 985632

031852
type: SpeciesReference
stoichiometry: 1.0
species: 986162

031735
type: SpeciesReference
stoichiometry: 1.0
species: 985413

031826
type: SpeciesReference
stoichiometry: 1.0
species: 985644

031787
type: SpeciesReference
stoichiometry: 1.0
species: 986729

986729
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: tridecanoyl-CoA (C13:0CoA)

031813
type: SpeciesReference
stoichiometry: 1.0
species: 985548

031913
type: LocalParameter
value: 500.0

031901
type: LocalParameter
value: 0.0

031889
type: LocalParameter
value: 1000.0

031877
type: LocalParameter
value: 0.0

031774
type: SpeciesReference
stoichiometry: 1.0
species: 986150

031761
type: SpeciesReference
stoichiometry: 1.0
species: 985848

031800
type: SpeciesReference
stoichiometry: 1.0
species: 985169

031839
type: SpeciesReference
stoichiometry: 1.0
species: 985836

076986
type: Reaction
product: 077049
reactant: 077025
fast: false
reactant: 076999
name: delta24-sterol reductase
reversible: false
reactant: 077012
kinetic law: 077061
product: 077037
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism

077049
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stoichiometry: 1.0
species: 987093

077025
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species: 987105

076999
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species: 986875

986875
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 5alpha-Cholesta-7,24-dien-3beta-ol

077012
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species: 987021

077109
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value: 500.0

077097
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value: 0.0

077085
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value: 1000.0

077073
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077037
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stoichiometry: 1.0
species: 987057

065780
type: Reaction
kinetic law: 065816
product: 065804
reactant: 065792
notes: GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: glucose-6-phosphate isomerase

065864
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value: 0.0

065852
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065840
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value: 1000.0

065828
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value: -1000.0

065804
type: SpeciesReference
stoichiometry: 1.0
species: 982656

065792
type: SpeciesReference
stoichiometry: 1.0
species: 982849

027112
type: Reaction
kinetic law: 027148
product: 027136
reactant: 027124
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase

027196
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value: 0.0

027184
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value: 0.0

027172
type: LocalParameter
value: 1000.0

027160
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value: -1000.0

027136
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stoichiometry: 1.0
species: 987057

027124
type: SpeciesReference
stoichiometry: 1.0
species: 987243

987243
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Zymostenol

036227
type: Reaction
reactant: 036275
reactant: 036263
name: fatty acid synthase (C15:0), cytosol
product: 036311
kinetic law: 036348
product: 036287
reversible: false
product: 036323
fast: false
product: 036335
reactant: 036251
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 036239
product: 036299

036275
type: SpeciesReference
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species: 984190

036263
type: SpeciesReference
stoichiometry: 12.0
species: 983685

036311
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stoichiometry: 5.0
species: 983078

036397
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value: 500.0

036384
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value: 0.0

036372
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value: 1000.0

036360
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value: 0.0

036287
type: SpeciesReference
stoichiometry: 6.0
species: 981979

036323
type: SpeciesReference
stoichiometry: 12.0
species: 983673

036335
type: SpeciesReference
stoichiometry: 1.0
species: 984322

036251
type: SpeciesReference
stoichiometry: 6.0
species: 983419

036239
type: SpeciesReference
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species: 983066

036299
type: SpeciesReference
stoichiometry: 7.0
species: 981991

985982
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Isobutyryl-CoA

017044
type: Reaction
kinetic law: 017106
reactant: 017056
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
name: octadecenoyl carnitine transport (C18:1Crn, n9)
fast: false
product: 017094
reversible: true
product: 017081
reactant: 017069

017156
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value: 0.0

017144
type: LocalParameter
value: 0.0

017132
type: LocalParameter
value: 1000.0

017119
type: LocalParameter
value: -1000.0

017056
type: SpeciesReference
stoichiometry: 1.0
species: 983878

983878
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecenoyl carnitine (C18:1Crn, n9)

017094
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stoichiometry: 1.0
species: 986330

017081
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stoichiometry: 1.0
species: 982040

017069
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stoichiometry: 1.0
species: 985450

987389
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Isopentenyl diphosphate

065876
type: Reaction
product: 065912
reactant: 065888
reactant: 065900
product: 065924
name: phosphoglycerate kinase
fast: false
reversible: true
kinetic law: 065936
notes: GENE_ASSOCIATION: (NM_000291.2 or NM_138733.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis

065912
type: SpeciesReference
stoichiometry: 1.0
species: 981183

065888
type: SpeciesReference
stoichiometry: 1.0
species: 980966

980966
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Phospho-D-glyceroyl phosphate

065900
type: SpeciesReference
stoichiometry: 1.0
species: 981557

065924
type: SpeciesReference
stoichiometry: 1.0
species: 981738

065984
type: LocalParameter
value: 0.0

065972
type: LocalParameter
value: 0.0

065960
type: LocalParameter
value: 1000.0

065948
type: LocalParameter
value: -1000.0

064571
type: Reaction
product: 064655
reactant: 064595
notes: GENE_ASSOCIATION: (NM_001040716.1 or NM_022172.1 or NM_000920.2) GENE_LIST: NM_000920.2 NM_001040716.1 NM_022172.1 SUBSYSTEM: Anaplerotic reactions
product: 064643
reactant: 064583
reactant: 064607
name: pyruvate carboxylase, mitochondrial
kinetic law: 064667
fast: false
reversible: false
product: 064619
product: 064631

064655
type: SpeciesReference
stoichiometry: 1.0
species: 986451

064595
type: SpeciesReference
stoichiometry: 1.0
species: 985873

064643
type: SpeciesReference
stoichiometry: 1.0
species: 986246

064583
type: SpeciesReference
stoichiometry: 1.0
species: 985279

064607
type: SpeciesReference
stoichiometry: 1.0
species: 986572

064715
type: LocalParameter
value: 500.0

064703
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value: 0.0

064691
type: LocalParameter
value: 1000.0

064679
type: LocalParameter
value: 0.0

064619
type: SpeciesReference
stoichiometry: 1.0
species: 985195

064631
type: SpeciesReference
stoichiometry: 1.0
species: 985836

988272
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: so3_b

987581
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: co2_b

981750
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: cAMP

985584
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: eicosatrienoyl-CoA (C20:3CoA, n-6)

983310
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: myo-Inositol

987353
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: H+

063688
type: Reaction
reactant: 063712
reactant: 063700
name: 2-oxoadipate transaminase, mitochondrial
product: 063736
reversible: true
product: 063724
notes: GENE_ASSOCIATION: (NM_016228.3 or NM_182662.1) GENE_LIST: NM_016228.3 NM_182662.1 SUBSYSTEM: Lysine Degradation
kinetic law: 063748
fast: false

063712
type: SpeciesReference
stoichiometry: 1.0
species: 985219

063700
type: SpeciesReference
stoichiometry: 1.0
species: 984866

984866
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-2-Aminoadipate

063736
type: SpeciesReference
stoichiometry: 1.0
species: 985752

063724
type: SpeciesReference
stoichiometry: 1.0
species: 984950

984950
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Oxoadipate

063796
type: LocalParameter
value: 0.0

063784
type: LocalParameter
value: 0.0

063772
type: LocalParameter
value: 1000.0

063760
type: LocalParameter
value: -1000.0

986379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: pentadecanoyl-CoA (C15:0CoA)

011287
type: Reaction
name: Ceramide synthase, myocyte
reversible: false
reactant: 011299
product: 011323
reactant: 011311
fast: false
product: 011348
kinetic law: 011360
product: 011336
notes: GENE_ASSOCIATION: (NM_147190.1 or NM_024552.1 or NM_198207.1 or NM_022075.2 or NM_178842.2 or NM_203463.1 or NM_021267.2 or NM_181746.1) GENE_LIST: NM_021267.2 NM_022075.2 NM_024552.1 NM_147190.1 NM_178842.2 NM_181746.1 NM_198207.1 NM_203463.1 SUBSYSTEM: Sphingomyelin

011299
type: SpeciesReference
stoichiometry: 0.001
species: 982680

982680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Averaged fatty acyl CoA, human myocyte

011323
type: SpeciesReference
stoichiometry: 1.0
species: 981991

011311
type: SpeciesReference
stoichiometry: 1.0
species: 984467

984467
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sphinganine

011348
type: SpeciesReference
stoichiometry: 1.0
species: 983066

011408
type: LocalParameter
value: 500.0

011396
type: LocalParameter
value: 0.0

011384
type: LocalParameter
value: 1000.0

011372
type: LocalParameter
value: 0.0

011336
type: SpeciesReference
stoichiometry: 0.001
species: 982174

982174
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dihydroceramide, Human Myocyte

074018
type: Reaction
kinetic law: 074104
reactant: 074042
reactant: 074030
name: sarcosine oxidase
product: 074091
fast: false
product: 074079
product: 074067
reactant: 074054
reversible: false
notes: GENE_ASSOCIATION: NM_016518.2 GENE_LIST: NM_016518.2 SUBSYSTEM: Glycine and Serine Metabolism

074152
type: LocalParameter
value: 500.0

074140
type: LocalParameter
value: 0.0

074128
type: LocalParameter
value: 1000.0

074116
type: LocalParameter
value: 0.0

074042
type: SpeciesReference
stoichiometry: 1.0
species: 987413

987413
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: O2

074030
type: SpeciesReference
stoichiometry: 1.0
species: 987365

987365
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: H2O

074091
type: SpeciesReference
stoichiometry: 1.0
species: 987377

987377
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Hydrogen peroxide

074079
type: SpeciesReference
stoichiometry: 1.0
species: 987341

987341
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Glycine

074067
type: SpeciesReference
stoichiometry: 1.0
species: 987329

074054
type: SpeciesReference
stoichiometry: 1.0
species: 987437

981351
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Methylthioadenosine

984070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Protoheme

041798
type: Reaction
product: 041846
kinetic law: 041858
notes: SUBSYSTEM: Glutathione Metabolism
product: 041834
name: gamma-glutamyltransferase
fast: false
reactant: 041822
reactant: 041810
reversible: false

041846
type: SpeciesReference
stoichiometry: 1.0
species: 982909

041906
type: LocalParameter
value: 500.0

041894
type: LocalParameter
value: 0.0

041882
type: LocalParameter
value: 1000.0

041870
type: LocalParameter
value: 0.0

041834
type: SpeciesReference
stoichiometry: 1.0
species: 981834

981834
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Cys-Gly

041822
type: SpeciesReference
stoichiometry: 1.0
species: 983078

041810
type: SpeciesReference
stoichiometry: 1.0
species: 983041

990759
type: Reaction
kinetic law: 990796
product: 990784
reactant: 990771
fast: false
reversible: true
name: Creatine exchange

990844
type: LocalParameter
value: 500.0

990832
type: LocalParameter
value: 0.0

990820
type: LocalParameter
value: 1000.0

990808
type: LocalParameter
value: 0.0

990784
type: SpeciesReference
stoichiometry: 1.0
species: 987593

987593
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: creat_b

990771
type: SpeciesReference
stoichiometry: 1.0
species: 980143

980143
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Creatine

072665
type: Reaction
name: pyruvate transport, mitochondrial
fast: false
kinetic law: 072725
reversible: false
reactant: 072689
product: 072713
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
product: 072701
reactant: 072677

072773
type: LocalParameter
value: 500.0

072761
type: LocalParameter
value: 0.0

072749
type: LocalParameter
value: 1000.0

072737
type: LocalParameter
value: 0.0

072689
type: SpeciesReference
stoichiometry: 1.0
species: 984346

072713
type: SpeciesReference
stoichiometry: 1.0
species: 986572

072701
type: SpeciesReference
stoichiometry: 1.0
species: 985836

072677
type: SpeciesReference
stoichiometry: 1.0
species: 983066

025492
type: Reaction
reversible: false
kinetic law: 025564
reactant: 025528
notes: GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Metabolism
reactant: 025504
reactant: 025516
product: 025540
product: 025552
fast: false
name: 7-dehydrocholesterol reductase

025612
type: LocalParameter
value: 500.0

025600
type: LocalParameter
value: 0.0

025588
type: LocalParameter
value: 1000.0

025576
type: LocalParameter
value: 0.0

025528
type: SpeciesReference
stoichiometry: 1.0
species: 987105

025504
type: SpeciesReference
stoichiometry: 1.0
species: 986851

986851
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 7-Dehydrocholesterol

025516
type: SpeciesReference
stoichiometry: 1.0
species: 987021

025540
type: SpeciesReference
stoichiometry: 1.0
species: 986887

025552
type: SpeciesReference
stoichiometry: 1.0
species: 987093

052346
type: Reaction
kinetic law: 052443
product: 052419
reversible: false
product: 052406
reactant: 052394
reactant: 052382
name: lathosterol oxidase (NADP), endoplasmic reticulum
fast: false
product: 052431
reactant: 052370
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Metabolism
reactant: 052358

052491
type: LocalParameter
value: 500.0

052479
type: LocalParameter
value: 0.0

052467
type: LocalParameter
value: 1000.0

052455
type: LocalParameter
value: 0.0

052419
type: SpeciesReference
stoichiometry: 2.0
species: 987033

052406
type: SpeciesReference
stoichiometry: 1.0
species: 986851

052394
type: SpeciesReference
stoichiometry: 1.0
species: 987117

052382
type: SpeciesReference
stoichiometry: 1.0
species: 987105

052431
type: SpeciesReference
stoichiometry: 1.0
species: 987093

052370
type: SpeciesReference
stoichiometry: 1.0
species: 987057

052358
type: SpeciesReference
stoichiometry: 1.0
species: 987021

027317
type: Reaction
kinetic law: 027366
product: 027354
reactant: 027342
reactant: 027329
notes: SUBSYSTEM: Valine degradation
fast: false
reversible: true
name: enoyl-CoA hydratase, mitochondrial

027415
type: LocalParameter
value: 0.0

027403
type: LocalParameter
value: 0.0

027390
type: LocalParameter
value: 1000.0

027378
type: LocalParameter
value: -1000.0

027354
type: SpeciesReference
stoichiometry: 1.0
species: 985909

985909
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-Hydroxyisobutyryl-CoA

027342
type: SpeciesReference
stoichiometry: 1.0
species: 985848

027329
type: SpeciesReference
stoichiometry: 1.0
species: 984926

988235
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ptdca_b

045030
type: Reaction
fast: false
kinetic law: 045090
name: glycogen synthase (UDPGlc)
product: 045054
notes: GENE_ASSOCIATION: ((NM_003918.1 and NM_021957.2) or (NM_001079855.1 and NM_021957.2) or (NM_004130.2 and NM_002103.3) or (NM_003918.1 and NM_002103.3) or (NM_001079855.1 and NM_002103.3) or (NM_004130.2 and NM_021957.2)) GENE_LIST: NM_001079855.1 NM_002103.3 NM_003918.1 NM_004130.2 NM_021957.2 SUBSYSTEM: Glycogen Metabolism
product: 045078
reversible: false
reactant: 045042
product: 045066

045139
type: LocalParameter
value: 500.0

045127
type: LocalParameter
value: 0.0

045115
type: LocalParameter
value: 1000.0

045103
type: LocalParameter
value: 0.0

045054
type: SpeciesReference
stoichiometry: 1.0
species: 982993

045078
type: SpeciesReference
stoichiometry: 1.0
species: 984708

984708
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: UDP

045042
type: SpeciesReference
stoichiometry: 1.0
species: 984721

984721
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: UDPglucose

045066
type: SpeciesReference
stoichiometry: 1.0
species: 983066

049410
type: Reaction
product: 049482
reversible: true
kinetic law: 049494
product: 049458
reactant: 049446
reactant: 049434
name: Hydroxymethylglutaryl CoA reductase
reactant: 049422
notes: GENE_ASSOCIATION: NM_000859.1 GENE_LIST: NM_000859.1 SUBSYSTEM: Cholesterol Metabolism
product: 049470
fast: false

049482
type: SpeciesReference
stoichiometry: 2.0
species: 983685

049543
type: LocalParameter
value: 0.0

049531
type: LocalParameter
value: 0.0

049519
type: LocalParameter
value: 1000.0

049506
type: LocalParameter
value: -1000.0

049458
type: SpeciesReference
stoichiometry: 2.0
species: 983066

049446
type: SpeciesReference
stoichiometry: 2.0
species: 983673

049434
type: SpeciesReference
stoichiometry: 1.0
species: 983493

983493
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (R)-Mevalonate

049422
type: SpeciesReference
stoichiometry: 1.0
species: 981991

049470
type: SpeciesReference
stoichiometry: 1.0
species: 983222

983222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Hydroxymethylglutaryl-CoA

049555
type: Reaction
reactant: 049580
product: 049604
name: Hydroxymethylglutaryl CoA synthase
fast: false
kinetic law: 049641
notes: GENE_ASSOCIATION: (NM_002130.4 or NM_001098272.1) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Metabolism
reactant: 049567
product: 049629
reactant: 049592
product: 049616
reversible: false

049580
type: SpeciesReference
stoichiometry: 1.0
species: 981496

049604
type: SpeciesReference
stoichiometry: 1.0
species: 981991

049689
type: LocalParameter
value: 500.0

049677
type: LocalParameter
value: 0.0

049665
type: LocalParameter
value: 1000.0

049653
type: LocalParameter
value: 0.0

049567
type: SpeciesReference
stoichiometry: 1.0
species: 981435

981435
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Acetoacetyl-CoA

049629
type: SpeciesReference
stoichiometry: 1.0
species: 983222

049592
type: SpeciesReference
stoichiometry: 1.0
species: 983078

049616
type: SpeciesReference
stoichiometry: 1.0
species: 983066

061874
type: Reaction
notes: SUBSYSTEM: Other
fast: false
product: 061922
name: Nucleoside triphosphate pyrophosphorylase (atp)
reactant: 061898
product: 061934
reversible: false
product: 061910
reactant: 061886
kinetic law: 061946

061922
type: SpeciesReference
stoichiometry: 1.0
species: 985836

061898
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species: 985848

061934
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species: 986512

986512
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Diphosphate

061910
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species: 985231

061886
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stoichiometry: 1.0
species: 985279

061994
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value: 500.0

061982
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value: 0.0

061970
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value: 1000.0

061958
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value: 0.0

986042
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Leucine

028320
type: Reaction
reactant: 028332
product: 028392
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_022977.1 or NM_203379.1 or NM_004457.3 or NM_004458.1 or NM_015256.2 or NM_016234.3 or NM_203372.1 or NM_203380.1 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 028344
name: fatty-acid--CoA ligase (hexadecanoate)
reversible: true
reactant: 028356
product: 028368
product: 028380
kinetic law: 028404
fast: false

028332
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species: 981738

028392
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stoichiometry: 1.0
species: 984202

028344
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stoichiometry: 1.0
species: 981991

028356
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species: 983126

028368
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stoichiometry: 1.0
species: 981666

028380
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stoichiometry: 1.0
species: 984130

028452
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value: 0.0

028440
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value: 0.0

028428
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value: 1000.0

028416
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value: -1000.0

047607
type: Reaction
kinetic law: 047667
product: 047655
fast: false
name: 3-hydroxybutyrate transport in/out via proton symport, blood
reactant: 047619
reversible: true
reactant: 047631
product: 047643
notes: GENE_ASSOCIATION: (NM_003051.3 or NM_013356.1 or NM_004696.1 or NM_004731.3 or NM_001042423.1 or NM_001042422.1 or NM_004207.1 or NM_004695.2 or NM_004694.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular

047716
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value: 0.0

047704
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value: 0.0

047692
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value: 1000.0

047680
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value: -1000.0

047655
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stoichiometry: 1.0
species: 983066

047619
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stoichiometry: 1.0
species: 979997

979997
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: (R)-3-Hydroxybutanoate

047631
type: SpeciesReference
stoichiometry: 1.0
species: 980435

047643
type: SpeciesReference
stoichiometry: 1.0
species: 981135

988078
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: o2_b

990369
type: Reaction
kinetic law: 990407
product: 990394
reactant: 990381
fast: false
reversible: true
name: Choline exchange

990455
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value: 0.0

990443
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value: 0.0

990431
type: LocalParameter
value: 1000.0

990419
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value: -1000.0

990394
type: SpeciesReference
stoichiometry: 1.0
species: 987545

987545
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: chol_b

990381
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stoichiometry: 1.0
species: 980095

980095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Choline

982463
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dUMP

070695
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Purine Metabolism
product: 070793
name: phosphoribosylformylglycinamidine synthase
product: 070781
product: 070756
reactant: 070719
product: 070805
product: 070769
reactant: 070744
reactant: 070731
kinetic law: 070817
reactant: 070707
fast: false

070793
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stoichiometry: 2.0
species: 983066

070781
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stoichiometry: 1.0
species: 982909

070756
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stoichiometry: 1.0
species: 981557

070719
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stoichiometry: 1.0
species: 982728

070805
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stoichiometry: 1.0
species: 984094

070769
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stoichiometry: 1.0
species: 982764

070744
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stoichiometry: 1.0
species: 983078

070731
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species: 982897

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value: 500.0

070853
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value: 0.0

070841
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value: 1000.0

070829
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value: 0.0

070707
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stoichiometry: 1.0
species: 981738

039811
type: Reaction
notes: SUBSYSTEM: Glutamate Metabolism
product: 039859
fast: false
kinetic law: 039871
reversible: true
reactant: 039823
product: 039847
product: 039835
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)

039859
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stoichiometry: 1.0
species: 983078

039920
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value: 0.0

039908
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value: 0.0

039896
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value: 1000.0

039883
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value: -1000.0

039823
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stoichiometry: 1.0
species: 982921

982921
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Glutamate 5-semialdehyde

039847
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stoichiometry: 1.0
species: 983066

039835
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stoichiometry: 1.0
species: 981002

981002
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 1-Pyrroline-5-carboxylate

074261
type: Reaction
kinetic law: 074297
product: 074285
reactant: 074273
notes: SUBSYSTEM: Glycine and Serine Metabolism
fast: false
reversible: true
name: Sarcosine transport (peroxisomal)

074345
type: LocalParameter
value: 0.0

074333
type: LocalParameter
value: 0.0

074321
type: LocalParameter
value: 1000.0

074309
type: LocalParameter
value: -1000.0

074285
type: SpeciesReference
stoichiometry: 1.0
species: 987437

074273
type: SpeciesReference
stoichiometry: 1.0
species: 984394

984394
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Sarcosine

987485
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: acac_b

984022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphatidylethanolamine, human hepatocyte

995504
type: Reaction
kinetic law: 995540
product: 995528
reactant: 995516
fast: false
reversible: true
name: Protoheme exchange

995589
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value: 500.0

995576
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value: 0.0

995564
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value: 1000.0

995552
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value: 0.0

995528
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stoichiometry: 1.0
species: 988186

988186
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: pheme_b

995516
type: SpeciesReference
stoichiometry: 1.0
species: 980745

980745
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Protoheme

029626
type: Reaction
reactant: 029638
product: 029699
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203379.1 or NM_016234.3 or NM_015256.2 or NM_203372.1 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reversible: true
reactant: 029650
fast: false
product: 029687
reactant: 029662
product: 029674
name: fatty-acid--CoA ligase (eicosapentaenoate, C20:5 n-3)
kinetic law: 029711

029638
type: SpeciesReference
stoichiometry: 1.0
species: 981738

029699
type: SpeciesReference
stoichiometry: 1.0
species: 984202

029650
type: SpeciesReference
stoichiometry: 1.0
species: 981991

029687
type: SpeciesReference
stoichiometry: 1.0
species: 982547

982547
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: eicosapentaenoyl-CoA (C20:5CoA, n-3)

029662
type: SpeciesReference
stoichiometry: 1.0
species: 982511

029674
type: SpeciesReference
stoichiometry: 1.0
species: 981666

029759
type: LocalParameter
value: 0.0

029747
type: LocalParameter
value: 0.0

029735
type: LocalParameter
value: 1000.0

029723
type: LocalParameter
value: -1000.0

073184
type: Reaction
reactant: 073208
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Pyrimidine Metabolism
reversible: false
reactant: 073196
product: 073232
kinetic law: 073256
product: 073220
name: ribonucleoside-diphosphate reductase (UDP)
product: 073244
fast: false

073208
type: SpeciesReference
stoichiometry: 1.0
species: 984708

073196
type: SpeciesReference
stoichiometry: 1.0
species: 984624

984624
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Reduced thioredoxin

073232
type: SpeciesReference
stoichiometry: 1.0
species: 983078

073304
type: LocalParameter
value: 500.0

073292
type: LocalParameter
value: 0.0

073280
type: LocalParameter
value: 1000.0

073268
type: LocalParameter
value: 0.0

073220
type: SpeciesReference
stoichiometry: 1.0
species: 982451

073244
type: SpeciesReference
stoichiometry: 1.0
species: 984612

984612
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Oxidized thioredoxin

983793
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecadienoyl-CoA (C18:2CoA, n-6)

058119
type: Reaction
product: 058179
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
reversible: false
product: 058191
reactant: 058131
product: 058167
kinetic law: 058203
fast: false
reactant: 058143
notes: GENE_ASSOCIATION: (((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3) or ((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Isoleucine degradation
reactant: 058155

058179
type: SpeciesReference
stoichiometry: 1.0
species: 985400

058191
type: SpeciesReference
stoichiometry: 1.0
species: 986162

058131
type: SpeciesReference
stoichiometry: 1.0
species: 985046

058167
type: SpeciesReference
stoichiometry: 1.0
species: 984914

984914
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 2-Methylbutanoyl-CoA

058251
type: LocalParameter
value: 500.0

058239
type: LocalParameter
value: 0.0

058227
type: LocalParameter
value: 1000.0

058215
type: LocalParameter
value: 0.0

058143
type: SpeciesReference
stoichiometry: 1.0
species: 985413

058155
type: SpeciesReference
stoichiometry: 1.0
species: 986150

003245
type: Reaction
kinetic law: 003281
product: 003269
reactant: 003257
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: alphaketobutyrate transport (mitochondrial)

003329
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value: 0.0

003317
type: LocalParameter
value: 0.0

003305
type: LocalParameter
value: 1000.0

003293
type: LocalParameter
value: -1000.0

003269
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stoichiometry: 1.0
species: 981063

981063
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Oxobutanoate

003257
type: SpeciesReference
stoichiometry: 1.0
species: 984938

043493
type: Reaction
product: 043554
fast: false
name: glutamate dehydrogenase (NAD), mitochondrial
notes: GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Anaplerotic reactions
reversible: true
product: 043578
reactant: 043517
reactant: 043529
product: 043566
product: 043541
reactant: 043505
kinetic law: 043590

043554
type: SpeciesReference
stoichiometry: 1.0
species: 985836

043578
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stoichiometry: 1.0
species: 986198

043517
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stoichiometry: 1.0
species: 985848

043529
type: SpeciesReference
stoichiometry: 1.0
species: 986150

043566
type: SpeciesReference
stoichiometry: 1.0
species: 986162

043541
type: SpeciesReference
stoichiometry: 1.0
species: 985219

043505
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stoichiometry: 1.0
species: 985752

043638
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value: 0.0

043626
type: LocalParameter
value: 0.0

043614
type: LocalParameter
value: 1000.0

043602
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value: -1000.0

987967
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ile_L_b

982246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dodecanoate (C12:0)

052767
type: Reaction
fast: false
kinetic law: 052829
product: 052803
notes: GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Leucine degradation
product: 052816
reactant: 052791
reversible: true
name: leucine transaminase
reactant: 052779

052882
type: LocalParameter
value: 0.0

052869
type: LocalParameter
value: 0.0

052856
type: LocalParameter
value: 1000.0

052843
type: LocalParameter
value: -1000.0

052803
type: SpeciesReference
stoichiometry: 1.0
species: 981279

052816
type: SpeciesReference
stoichiometry: 1.0
species: 982909

052791
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stoichiometry: 1.0
species: 983371

052779
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stoichiometry: 1.0
species: 981617

075250
type: Reaction
fast: false
product: 075299
notes: GENE_ASSOCIATION: (NM_001077484.1 or NM_018976.3 or NM_007231.1 or NM_030674.2 or NM_018018.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
name: L-serine via sodium symport, blood
reversible: true
kinetic law: 075311
product: 075287
reactant: 075275
reactant: 075263

075299
type: SpeciesReference
stoichiometry: 1.0
species: 984418

075359
type: LocalParameter
value: 0.0

075347
type: LocalParameter
value: 0.0

075335
type: LocalParameter
value: 1000.0

075323
type: LocalParameter
value: -1000.0

075287
type: SpeciesReference
stoichiometry: 1.0
species: 983637

075275
type: SpeciesReference
stoichiometry: 1.0
species: 980818

075263
type: SpeciesReference
stoichiometry: 1.0
species: 980605

996466
type: Reaction
kinetic law: 996502
product: 996490
reactant: 996478
fast: false
reversible: true
name: tetradecanoate (C14:0) exchange

996551
type: LocalParameter
value: 500.0

996539
type: LocalParameter
value: 0.0

996527
type: LocalParameter
value: 1000.0

996514
type: LocalParameter
value: 0.0

996490
type: SpeciesReference
stoichiometry: 1.0
species: 988308

988308
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ttdca_b

996478
type: SpeciesReference
stoichiometry: 1.0
species: 980867

066699
type: Reaction
kinetic law: 066735
product: 066723
reactant: 066711
notes: GENE_ASSOCIATION: (NM_000613.1 or NM_080669.2) GENE_LIST: NM_000613.1 NM_080669.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: heme transport, blood

066784
type: LocalParameter
value: 0.0

066771
type: LocalParameter
value: 0.0

066759
type: LocalParameter
value: 1000.0

066747
type: LocalParameter
value: -1000.0

066723
type: SpeciesReference
stoichiometry: 1.0
species: 984070

066711
type: SpeciesReference
stoichiometry: 1.0
species: 980745

066555
type: Reaction
reactant: 066579
notes: GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine metabolism
product: 066603
product: 066615
reactant: 066567
name: phenylalanine 4-monooxygenase
reactant: 066591
reversible: false
product: 066627
fast: false
kinetic law: 066639

066579
type: SpeciesReference
stoichiometry: 1.0
species: 984058

066603
type: SpeciesReference
stoichiometry: 1.0
species: 982306

982306
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 6,7-Dihydrobiopterin

066615
type: SpeciesReference
stoichiometry: 1.0
species: 983078

066567
type: SpeciesReference
stoichiometry: 1.0
species: 983709

066591
type: SpeciesReference
stoichiometry: 1.0
species: 984564

066627
type: SpeciesReference
stoichiometry: 1.0
species: 984696

066687
type: LocalParameter
value: 500.0

066675
type: LocalParameter
value: 0.0

066663
type: LocalParameter
value: 1000.0

066651
type: LocalParameter
value: 0.0

026711
type: Reaction
reversible: false
product: 026784
reactant: 026735
kinetic law: 026796
notes: SUBSYSTEM: Cholesterol Metabolism
product: 026747
name: diphosphomevalonate decarboxylase
fast: false
product: 026759
reactant: 026723
product: 026772

026784
type: SpeciesReference
stoichiometry: 1.0
species: 987425

987425
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: Phosphate

026735
type: SpeciesReference
stoichiometry: 1.0
species: 987293

026846
type: LocalParameter
value: 500.0

026834
type: LocalParameter
value: 0.0

026821
type: LocalParameter
value: 1000.0

026808
type: LocalParameter
value: 0.0

026747
type: SpeciesReference
stoichiometry: 1.0
species: 987281

026759
type: SpeciesReference
stoichiometry: 1.0
species: 987305

987305
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: CO2

026723
type: SpeciesReference
stoichiometry: 1.0
species: 987256

987256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979960
name: (R)-5-Diphosphomevalonate

026772
type: SpeciesReference
stoichiometry: 1.0
species: 987389

071735
type: Reaction
product: 071771
name: phosphoserine phosphatase (L-serine)
reversible: false
fast: false
notes: GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine and Serine Metabolism
product: 071783
kinetic law: 071795
reactant: 071747
reactant: 071759

071771
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stoichiometry: 1.0
species: 984094

071783
type: SpeciesReference
stoichiometry: 1.0
species: 984418

071845
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value: 500.0

071832
type: LocalParameter
value: 0.0

071820
type: LocalParameter
value: 1000.0

071808
type: LocalParameter
value: 0.0

071747
type: SpeciesReference
stoichiometry: 1.0
species: 983078

071759
type: SpeciesReference
stoichiometry: 1.0
species: 984310

988296
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: trp_L_b

024600
type: Reaction
name: stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
notes: GENE_ASSOCIATION: (NM_021727.3 or NM_004265.2) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 024624
reactant: 024648
fast: false
product: 024672
kinetic law: 024697
product: 024660
reactant: 024612
reversible: false
reactant: 024636
product: 024684

024624
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stoichiometry: 1.0
species: 983685

024648
type: SpeciesReference
stoichiometry: 1.0
species: 983829

024672
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054491
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020305
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020379
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020317
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002978
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003016
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002991
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003029
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994926
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024914
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026591
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026639
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068272
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015958
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notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
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016006
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035679
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notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
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035848
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988259
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062201
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062225
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076133
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076194
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073510
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notes: GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
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073583
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073571
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073535
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073523
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024757
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product: 024841
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reactant: 024793
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024877
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024781
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061633
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061718
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061706
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061645
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species: 982427

061657
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species: 983078

069260
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notes: GENE_ASSOCIATION: (NM_001018073.1 or NM_004563.2) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Aspartate Degradation
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name: Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
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product: 069308
product: 069320

069296
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species: 985400

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069344
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069284
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069272
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species: 985824

985824
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985728
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078951
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product: 078999
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notes: SUBSYSTEM: Pentose Phosphate Pathway

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name: D-Xylulose 5-phosphate

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species: 986935

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079047
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006283
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notes: GENE_ASSOCIATION: NM_000045.2 GENE_LIST: NM_000045.2 SUBSYSTEM: Arginine Metabolism
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006355
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006319
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061391
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species: 982234

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initial concentration: NaN
initial amount: NaN
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061487
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061475
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061463
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069958
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reactant: 069970
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notes: GENE_ASSOCIATION: (NM_000309.3 or NM_001122764.1) GENE_LIST: NM_000309.3 NM_001122764.1 SUBSYSTEM: Heme Biosynthesis

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species: 984226

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initial concentration: NaN
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name: Protoporphyrinogen IX

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species: 983078

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species: 983709

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species: 984214

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056504
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species: 987353

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025756
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product: 025804
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product: 025792
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notes: GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Pyrimidine Metabolism

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025828
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004508
type: Reaction
kinetic law: 004573
name: Alanine-Sodium symporter, blood
fast: false
reactant: 004521
product: 004560
reactant: 004534
notes: GENE_ASSOCIATION: (NM_003038.2 or NM_005628.1 or NM_018018.2) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
reversible: true
product: 004547

004624
type: LocalParameter
value: 0.0

004612
type: LocalParameter
value: 0.0

004599
type: LocalParameter
value: 1000.0

004586
type: LocalParameter
value: -1000.0

004521
type: SpeciesReference
stoichiometry: 1.0
species: 980046

004560
type: SpeciesReference
stoichiometry: 1.0
species: 983637

004534
type: SpeciesReference
stoichiometry: 1.0
species: 980605

004547
type: SpeciesReference
stoichiometry: 1.0
species: 981629

044197
type: Reaction
kinetic law: 044233
product: 044221
reactant: 044209
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: L-Glutamate 5-semialdehyde transport, mitochondrial

044282
type: LocalParameter
value: 0.0

044270
type: LocalParameter
value: 0.0

044257
type: LocalParameter
value: 1000.0

044245
type: LocalParameter
value: -1000.0

044221
type: SpeciesReference
stoichiometry: 1.0
species: 985776

044209
type: SpeciesReference
stoichiometry: 1.0
species: 982921

051572
type: Reaction
kinetic law: 051608
product: 051596
reactant: 051584
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: isopentenyl diphosphate transport, peroxisome

051656
type: LocalParameter
value: 0.0

051644
type: LocalParameter
value: 0.0

051632
type: LocalParameter
value: 1000.0

051620
type: LocalParameter
value: -1000.0

051596
type: SpeciesReference
stoichiometry: 1.0
species: 983322

983322
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Isopentenyl diphosphate

051584
type: SpeciesReference
stoichiometry: 1.0
species: 987389

986753
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Urea

983359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Lactate

987665
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: dcspea6_b

043215
type: Reaction
product: 043289
fast: false
reactant: 043227
product: 043277
kinetic law: 043313
name: glutamate-cysteine ligase
reactant: 043240
product: 043265
reversible: false
product: 043301
reactant: 043252
notes: GENE_ASSOCIATION: (NM_001498.2 and NM_002061.2) GENE_LIST: NM_001498.2 NM_002061.2 SUBSYSTEM: Glutathione Metabolism

043289
type: SpeciesReference
stoichiometry: 1.0
species: 983066

043227
type: SpeciesReference
stoichiometry: 1.0
species: 981738

043277
type: SpeciesReference
stoichiometry: 1.0
species: 982933

982933
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: gamma-L-Glutamyl-L-cysteine

043361
type: LocalParameter
value: 500.0

043349
type: LocalParameter
value: 0.0

043337
type: LocalParameter
value: 1000.0

043325
type: LocalParameter
value: 0.0

043240
type: SpeciesReference
stoichiometry: 1.0
species: 982077

043265
type: SpeciesReference
stoichiometry: 1.0
species: 981557

043301
type: SpeciesReference
stoichiometry: 1.0
species: 984094

043252
type: SpeciesReference
stoichiometry: 1.0
species: 982909

005645
type: Reaction
name: Adenosine monophosphate deaminase
reactant: 005669
fast: false
kinetic law: 005717
product: 005693
reactant: 005657
product: 005705
reversible: false
notes: GENE_ASSOCIATION: (NM_001025389.1 or NM_000036.1 or NM_000480.2 or NM_001025390.1 or NM_203404.1 or NM_139156.2 or NM_004037.6) GENE_LIST: NM_000036.1 NM_000480.2 NM_001025389.1 NM_001025390.1 NM_004037.6 NM_139156.2 NM_203404.1 SUBSYSTEM: Purine Nucleotide Cycle
reactant: 005681

005669
type: SpeciesReference
stoichiometry: 1.0
species: 983066

005765
type: LocalParameter
value: 500.0

005753
type: LocalParameter
value: 0.0

005741
type: LocalParameter
value: 1000.0

005729
type: LocalParameter
value: 0.0

005693
type: SpeciesReference
stoichiometry: 1.0
species: 983297

005657
type: SpeciesReference
stoichiometry: 1.0
species: 981666

005705
type: SpeciesReference
stoichiometry: 1.0
species: 983697

005681
type: SpeciesReference
stoichiometry: 1.0
species: 983078

030362
type: Reaction
product: 030482
reactant: 030398
fast: false
product: 030470
product: 030434
product: 030458
name: fatty-acyl-CoA elongation (n-C20:3CoA, n6)
reactant: 030386
notes: SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 030410
reactant: 030374
kinetic law: 030494
reactant: 030422
reversible: false
product: 030446

030482
type: SpeciesReference
stoichiometry: 4.0
species: 983673

030398
type: SpeciesReference
stoichiometry: 4.0
species: 983685

030470
type: SpeciesReference
stoichiometry: 3.0
species: 983078

030434
type: SpeciesReference
stoichiometry: 1.0
species: 981979

030458
type: SpeciesReference
stoichiometry: 1.0
species: 982571

030386
type: SpeciesReference
stoichiometry: 1.0
species: 983419

030410
type: SpeciesReference
stoichiometry: 1.0
species: 983709

030374
type: SpeciesReference
stoichiometry: 5.0
species: 983066

030542
type: LocalParameter
value: 500.0

030530
type: LocalParameter
value: 0.0

030518
type: LocalParameter
value: 1000.0

030506
type: LocalParameter
value: 0.0

030422
type: SpeciesReference
stoichiometry: 1.0
species: 983841

983841
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecatrienoyl-CoA (C18:3CoA, n-6)

030446
type: SpeciesReference
stoichiometry: 1.0
species: 981991

992800
type: Reaction
kinetic law: 992836
product: 992824
reactant: 992812
fast: false
reversible: true
name: L-Glutamate exchange

992884
type: LocalParameter
value: 500.0

992872
type: LocalParameter
value: 0.0

992860
type: LocalParameter
value: 1000.0

992848
type: LocalParameter
value: 0.0

992824
type: SpeciesReference
stoichiometry: 1.0
species: 987847

987847
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: glu_L_b

992812
type: SpeciesReference
stoichiometry: 1.0
species: 980399

980399
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Glutamate

983198
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Hydroxy-L-kynurenine

996369
type: Reaction
kinetic law: 996406
product: 996394
reactant: 996382
fast: false
reversible: true
name: L-Tryptophan exchange

996454
type: LocalParameter
value: -2.75E-4

996442
type: LocalParameter
value: 0.0

996430
type: LocalParameter
value: 0.0

996418
type: LocalParameter
value: -5.5E-4

996394
type: SpeciesReference
stoichiometry: 1.0
species: 988296

996382
type: SpeciesReference
stoichiometry: 1.0
species: 980855

980855
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Tryptophan

997204
type: Reaction
fast: false
reversible: true
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Extracellular
name: 3-Hydroxy-2-methylpropanoate, proton symporter
kinetic law: 997264
product: 997252
reactant: 997228
product: 997240
reactant: 997216

997314
type: LocalParameter
value: 0.0

997301
type: LocalParameter
value: 0.0

997289
type: LocalParameter
value: 1000.0

997276
type: LocalParameter
value: -1000.0

997252
type: SpeciesReference
stoichiometry: 1.0
species: 980435

997228
type: SpeciesReference
stoichiometry: 1.0
species: 983066

997240
type: SpeciesReference
stoichiometry: 1.0
species: 980009

980009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: (S)-3-hydroxyisobutyrate

997216
type: SpeciesReference
stoichiometry: 1.0
species: 981147

981147
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: (S)-3-hydroxyisobutyrate

986294
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: octadecatrienoyl-CoA (C18:3CoA, n-3)

984962
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (R)-3-Hydroxybutanoate

986536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Proline

982270
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dGMP

006403
type: Reaction
name: arginase (m)
notes: GENE_ASSOCIATION: NM_001172.3 GENE_LIST: NM_001172.3 SUBSYSTEM: Arginine Metabolism
kinetic law: 006463
reversible: false
product: 006451
fast: false
reactant: 006427
product: 006439
reactant: 006415

006512
type: LocalParameter
value: 500.0

006500
type: LocalParameter
value: 0.0

006488
type: LocalParameter
value: 1000.0

006475
type: LocalParameter
value: 0.0

006451
type: SpeciesReference
stoichiometry: 1.0
species: 986753

006427
type: SpeciesReference
stoichiometry: 1.0
species: 985848

006439
type: SpeciesReference
stoichiometry: 1.0
species: 986343

006415
type: SpeciesReference
stoichiometry: 1.0
species: 985255

078470
type: Reaction
fast: false
kinetic law: 078530
product: 078518
notes: GENE_ASSOCIATION: (NM_001077484.1 or NM_007231.1 or NM_018976.3 or NM_030674.2 or NM_018018.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
name: L-threonine via sodium symport, blood
product: 078506
reactant: 078494
reversible: true
reactant: 078482

078578
type: LocalParameter
value: 0.0

078566
type: LocalParameter
value: 0.0

078554
type: LocalParameter
value: 1000.0

078542
type: LocalParameter
value: -1000.0

078518
type: SpeciesReference
stoichiometry: 1.0
species: 984588

078506
type: SpeciesReference
stoichiometry: 1.0
species: 983637

078494
type: SpeciesReference
stoichiometry: 1.0
species: 980843

078482
type: SpeciesReference
stoichiometry: 1.0
species: 980605

079844
type: Reaction
reactant: 079868
kinetic law: 079905
product: 079881
name: triglycerol synthesis, human myocyte
fast: false
product: 079893
reactant: 079856
notes: GENE_ASSOCIATION: (NM_178176.2 or NM_012079.3 or NM_032564.2) GENE_LIST: NM_012079.3 NM_032564.2 NM_178176.2 SUBSYSTEM: Triglycerol Synthesis
reversible: false

079868
type: SpeciesReference
stoichiometry: 0.001
species: 982680

079953
type: LocalParameter
value: 500.0

079941
type: LocalParameter
value: 0.0

079929
type: LocalParameter
value: 1000.0

079917
type: LocalParameter
value: 0.0

079881
type: SpeciesReference
stoichiometry: 1.0
species: 981991

079893
type: SpeciesReference
stoichiometry: 0.001
species: 984648

079856
type: SpeciesReference
stoichiometry: 0.001
species: 980954

981931
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Citrulline

021453
type: Reaction
reactant: 021466
reactant: 021478
fast: false
product: 021502
product: 021490
name: cystathionine b-synthase
kinetic law: 021514
reversible: false
notes: GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Methionine Metabolism

021466
type: SpeciesReference
stoichiometry: 1.0
species: 983114

983114
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Homocysteine

021478
type: SpeciesReference
stoichiometry: 1.0
species: 984418

021502
type: SpeciesReference
stoichiometry: 1.0
species: 983078

021490
type: SpeciesReference
stoichiometry: 1.0
species: 982089

982089
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: L-Cystathionine

021564
type: LocalParameter
value: 500.0

021551
type: LocalParameter
value: 0.0

021539
type: LocalParameter
value: 1000.0

021526
type: LocalParameter
value: 0.0

006911
type: Reaction
kinetic law: 006947
product: 006935
reactant: 006923
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_001048164.1 or NM_003045.3 or NM_003046.2 or NM_032803.3 or NM_003486.5 or NM_001126106.1 or NM_001126105.1 or NM_012244.2 or NM_003982.3 or NM_182728.1 or NM_001008539.1) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_001126105.1 NM_001126106.1 NM_003045.3 NM_003046.2 NM_003486.5 NM_003982.3 NM_012244.2 NM_018018.2 NM_032803.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Arginine transport, blood

006995
type: LocalParameter
value: 0.0

006983
type: LocalParameter
value: 0.0

006971
type: LocalParameter
value: 1000.0

006959
type: LocalParameter
value: -1000.0

006935
type: SpeciesReference
stoichiometry: 1.0
species: 981690

006923
type: SpeciesReference
stoichiometry: 1.0
species: 980058

982861
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: N1-(5-Phospho-D-ribosyl)glycinamide

022570
type: Reaction
product: 022631
product: 022607
reversible: false
product: 022619
notes: GENE_ASSOCIATION: (NM_001007794.1 or NM_020244.2 or NM_006090.3) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Metabolism
reactant: 022583
name: diacylglycerol cholinephosphotransferase, human myocyte
reactant: 022595
fast: false
kinetic law: 022643

022631
type: SpeciesReference
stoichiometry: 0.001
species: 983974

022607
type: SpeciesReference
stoichiometry: 1.0
species: 981967

022619
type: SpeciesReference
stoichiometry: 1.0
species: 983066

022583
type: SpeciesReference
stoichiometry: 0.001
species: 980954

022595
type: SpeciesReference
stoichiometry: 1.0
species: 981798

022691
type: LocalParameter
value: 500.0

022679
type: LocalParameter
value: 0.0

022667
type: LocalParameter
value: 1000.0

022655
type: LocalParameter
value: 0.0

010429
type: Reaction
product: 010490
product: 010514
reactant: 010441
name: carbamoyl-phosphate synthase (glutamine-hydrolysing)
product: 010538
reversible: false
reactant: 010453
product: 010502
kinetic law: 010550
reactant: 010477
reactant: 010465
product: 010526
fast: false
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Metabolism

010490
type: SpeciesReference
stoichiometry: 2.0
species: 981557

010514
type: SpeciesReference
stoichiometry: 1.0
species: 982909

010441
type: SpeciesReference
stoichiometry: 2.0
species: 981738

010538
type: SpeciesReference
stoichiometry: 1.0
species: 984094

010453
type: SpeciesReference
stoichiometry: 1.0
species: 982897

010502
type: SpeciesReference
stoichiometry: 1.0
species: 981774

010599
type: LocalParameter
value: 500.0

010587
type: LocalParameter
value: 0.0

010574
type: LocalParameter
value: 1000.0

010562
type: LocalParameter
value: 0.0

010477
type: SpeciesReference
stoichiometry: 1.0
species: 983102

010465
type: SpeciesReference
stoichiometry: 1.0
species: 983078

010526
type: SpeciesReference
stoichiometry: 2.0
species: 983066

071613
type: Reaction
name: 3-phosphoserine aminotransferase
reactant: 071625
reversible: true
product: 071649
kinetic law: 071673
fast: false
notes: GENE_ASSOCIATION: (NM_058179.2 or NM_021154.3) GENE_LIST: NM_021154.3 NM_058179.2 SUBSYSTEM: Glycine and Serine Metabolism
product: 071661
reactant: 071637

071625
type: SpeciesReference
stoichiometry: 1.0
species: 981195

071649
type: SpeciesReference
stoichiometry: 1.0
species: 981617

071722
type: LocalParameter
value: 0.0

071709
type: LocalParameter
value: 0.0

071697
type: LocalParameter
value: 1000.0

071685
type: LocalParameter
value: -1000.0

071661
type: SpeciesReference
stoichiometry: 1.0
species: 984310

071637
type: SpeciesReference
stoichiometry: 1.0
species: 982909

987811
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: gal_b

041096
type: Reaction
reactant: 041132
notes: GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 041168
name: glyceraldehyde-3-phosphate dehydrogenase (NAD)
reversible: true
product: 041144
kinetic law: 041180
reactant: 041120
product: 041156
fast: false
reactant: 041108

041132
type: SpeciesReference
stoichiometry: 1.0
species: 984094

041168
type: SpeciesReference
stoichiometry: 1.0
species: 983661

041144
type: SpeciesReference
stoichiometry: 1.0
species: 980966

041228
type: LocalParameter
value: 0.0

041216
type: LocalParameter
value: 0.0

041204
type: LocalParameter
value: 1000.0

041192
type: LocalParameter
value: -1000.0

041120
type: SpeciesReference
stoichiometry: 1.0
species: 983649

041156
type: SpeciesReference
stoichiometry: 1.0
species: 983066

041108
type: SpeciesReference
stoichiometry: 1.0
species: 982836

058504
type: Reaction
name: methylenetetrahydrofolate dehydrogenase (NADP)
fast: false
reactant: 058516
product: 058552
notes: SUBSYSTEM: Folate Metabolism
kinetic law: 058564
reactant: 058528
product: 058540
reversible: true

058516
type: SpeciesReference
stoichiometry: 1.0
species: 983529

983529
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5,10-Methylenetetrahydrofolate

058552
type: SpeciesReference
stoichiometry: 1.0
species: 983685

058612
type: LocalParameter
value: 0.0

058600
type: LocalParameter
value: 0.0

058588
type: LocalParameter
value: 1000.0

058576
type: LocalParameter
value: -1000.0

058528
type: SpeciesReference
stoichiometry: 1.0
species: 983673

058540
type: SpeciesReference
stoichiometry: 1.0
species: 983481

988017
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: lys_L_b

049846
type: Reaction
kinetic law: 049882
product: 049870
reactant: 049858
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport

049930
type: LocalParameter
value: 0.0

049918
type: LocalParameter
value: 0.0

049906
type: LocalParameter
value: 1000.0

049894
type: LocalParameter
value: -1000.0

049870
type: SpeciesReference
stoichiometry: 1.0
species: 985921

049858
type: SpeciesReference
stoichiometry: 1.0
species: 983222

062103
type: Reaction
kinetic law: 062140
product: 062127
reactant: 062115
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: O2 endoplamic reticulum transport

062189
type: LocalParameter
value: 0.0

062177
type: LocalParameter
value: 0.0

062165
type: LocalParameter
value: 1000.0

062152
type: LocalParameter
value: -1000.0

062127
type: SpeciesReference
stoichiometry: 1.0
species: 987117

062115
type: SpeciesReference
stoichiometry: 1.0
species: 983709

992404
type: Reaction
kinetic law: 992440
product: 992428
reactant: 992416
fast: false
reversible: true
name: D-Fructose exchange

992488
type: LocalParameter
value: 500.0

992476
type: LocalParameter
value: 0.0

992464
type: LocalParameter
value: 1000.0

992452
type: LocalParameter
value: 0.0

992428
type: SpeciesReference
stoichiometry: 1.0
species: 987799

987799
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: fru_b

992416
type: SpeciesReference
stoichiometry: 1.0
species: 980350

035100
type: Reaction
fast: false
product: 035172
reactant: 035136
kinetic law: 035232
product: 035196
product: 035184
reactant: 035124
reactant: 035148
reversible: false
reactant: 035160
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
reactant: 035112
product: 035208
product: 035220
name: Beta oxidation of odd chain fatty acid

035172
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stoichiometry: 1.0
species: 985169

035136
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stoichiometry: 1.0
species: 985848

035281
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value: 500.0

035269
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value: 0.0

035257
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value: 1000.0

035244
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stoichiometry: 1.0
species: 985836

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species: 985644

035124
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species: 985632

035148
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stoichiometry: 1.0
species: 985933

985933
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: heptanoyl-CoA (C7:0CoA)

035160
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species: 986150

035112
type: SpeciesReference
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species: 985413

035208
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species: 986162

035220
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species: 986548

986548
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Pentanoyl-CoA (C5:0CoA)

995215
type: Reaction
kinetic law: 995251
product: 995239
reactant: 995227
fast: false
reversible: true
name: ocosatetraenoate (C22:4, n-6) exchange

995299
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value: 500.0

995287
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value: 0.0

995275
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value: 1000.0

995263
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value: 0.0

995239
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species: 988150

988150
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: ocsttea6_b

995227
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species: 980706

980706
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: ocosatetraenoate (C22:4, n-6)

055625
type: Reaction
product: 055673
reactant: 055637
reactant: 055649
product: 055685
product: 055661
reversible: true
fast: false
kinetic law: 055698
notes: GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Anaplerotic reactions
name: malic enzyme (NADP)

055673
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stoichiometry: 1.0
species: 983685

055637
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stoichiometry: 1.0
species: 983407

055649
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species: 983673

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species: 984346

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species: 981979

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055734
type: LocalParameter
value: 0.0

055722
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value: 1000.0

055710
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value: -1000.0

047367
type: Reaction
product: 047415
notes: GENE_ASSOCIATION: (NM_004493.2 or NM_001037811.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Isoleucine degradation
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
product: 047403
reactant: 047391
kinetic law: 047439
reactant: 047379
product: 047427
reversible: true

047415
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species: 985836

047403
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species: 984890

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species: 986150

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047463
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047451
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047379
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species: 984986

984986
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-Hydroxy-2-methylbutyryl-CoA

047427
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species: 986162

013555
type: Reaction
kinetic law: 013604
product: 013591
product: 013579
reactant: 013567
notes: SUBSYSTEM: Contraction
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reversible: false
name: muscle contraction, myocyte cytosol

013652
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013640
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013628
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value: 1000.0

013616
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013591
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stoichiometry: 1.0
species: 983577

013579
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stoichiometry: 1.0
species: 981557

013567
type: SpeciesReference
stoichiometry: 1.0
species: 983589

009075
type: Reaction
reversible: true
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
product: 009123
kinetic law: 009147
fast: false
notes: GENE_ASSOCIATION: (NM_203315.2 or NM_004051.4 or NM_203314.2) GENE_LIST: NM_004051.4 NM_203314.2 NM_203315.2 SUBSYSTEM: Ketone Body Utilization
product: 009111
reactant: 009087
reactant: 009099
product: 009135

009123
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species: 985836

009195
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009183
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value: 0.0

009171
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009159
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value: -1000.0

009111
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species: 985156

009087
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species: 984962

009099
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stoichiometry: 1.0
species: 986150

009135
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species: 986162

080858
type: Reaction
product: 080894
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
reactant: 080882
product: 080907
reversible: false
notes: GENE_ASSOCIATION: NM_000374.3 GENE_LIST: NM_000374.3 SUBSYSTEM: Heme Biosynthesis
fast: false
kinetic law: 080919
reactant: 080870

080894
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species: 981979

080882
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species: 984745

984745
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Uroporphyrinogen III

080907
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species: 982003

982003
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Coproporphyrinogen III

080968
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value: 500.0

080956
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value: 0.0

080944
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value: 1000.0

080932
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080870
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species: 983066

026349
type: Reaction
reversible: false
reactant: 026361
product: 026397
product: 026409
name: dephospho-CoA kinase
kinetic law: 026421
product: 026385
notes: GENE_ASSOCIATION: (NM_001042529.1 or NM_001042532.1 or NM_001042530.1 or NM_001042531.1 or NM_025233.4) GENE_LIST: NM_001042529.1 NM_001042530.1 NM_001042531.1 NM_001042532.1 NM_025233.4 SUBSYSTEM: CoA Biosynthesis
fast: false
reactant: 026373

026361
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species: 981738

026397
type: SpeciesReference
stoichiometry: 1.0
species: 981991

026409
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species: 983066

026469
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value: 500.0

026457
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value: 0.0

026445
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value: 1000.0

026433
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value: 0.0

026385
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stoichiometry: 1.0
species: 981557

026373
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stoichiometry: 1.0
species: 982355

983926
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphatidate, Hepatocyte

992114
type: Reaction
kinetic law: 992150
product: 992138
reactant: 992126
fast: false
reversible: true
name: eicosatetraenoate (C20:4, n-6) exchange

992199
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value: 500.0

992187
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value: 0.0

992174
type: LocalParameter
value: 1000.0

992162
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value: 0.0

992138
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species: 987762

992126
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species: 980314

982475
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Deoxyuridine

009207
type: Reaction
reactant: 009245
fast: false
name: C-14 sterol reductase, endoplasmic reticulum
reversible: false
product: 009269
notes: GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Metabolism
kinetic law: 009281
reactant: 009220
reactant: 009233
product: 009257

009245
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species: 987105

009269
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species: 987093

009329
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value: 500.0

009317
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009305
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value: 1000.0

009293
type: LocalParameter
value: 0.0

009220
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stoichiometry: 1.0
species: 986777

009233
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species: 987021

009257
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stoichiometry: 1.0
species: 986790

986790
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 4,4-dimethylzymosterol

072315
type: Reaction
kinetic law: 072351
product: 072339
reactant: 072327
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: putrescine transport, mitochondria

072399
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072387
type: LocalParameter
value: 0.0

072375
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value: 1000.0

072363
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072339
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species: 984334

072327
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species: 986560

986560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Putrescine

993090
type: Reaction
kinetic law: 993126
product: 993114
reactant: 993102
fast: false
reversible: true
name: H+ exchange

993175
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value: 0.0

993163
type: LocalParameter
value: 0.0

993151
type: LocalParameter
value: 1000.0

993139
type: LocalParameter
value: -1000.0

993114
type: SpeciesReference
stoichiometry: 1.0
species: 987895

993102
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stoichiometry: 1.0
species: 980435

041240
type: Reaction
reactant: 041252
product: 041276
product: 041300
kinetic law: 041312
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine Metabolism
name: phosphoribosylglycinamide formyltransferase, irreversible
fast: false
reactant: 041264
reversible: false
product: 041288

041252
type: SpeciesReference
stoichiometry: 1.0
species: 980929

980929
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 10-Formyltetrahydrofolate

041276
type: SpeciesReference
stoichiometry: 1.0
species: 982728

041300
type: SpeciesReference
stoichiometry: 1.0
species: 984576

041361
type: LocalParameter
value: 500.0

041349
type: LocalParameter
value: 0.0

041337
type: LocalParameter
value: 1000.0

041324
type: LocalParameter
value: 0.0

041264
type: SpeciesReference
stoichiometry: 1.0
species: 982861

041288
type: SpeciesReference
stoichiometry: 1.0
species: 983066

005777
type: Reaction
fast: false
reactant: 005801
reactant: 005789
product: 005825
reversible: false
notes: GENE_ASSOCIATION: NM_001150.2 GENE_LIST: NM_001150.2 SUBSYSTEM: Glutathione Metabolism
kinetic law: 005837
name: alanyl aminopeptidase (cys-gly)
product: 005813

005801
type: SpeciesReference
stoichiometry: 1.0
species: 983078

005789
type: SpeciesReference
stoichiometry: 1.0
species: 981834

005825
type: SpeciesReference
stoichiometry: 1.0
species: 982945

005885
type: LocalParameter
value: 500.0

005873
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value: 0.0

005861
type: LocalParameter
value: 1000.0

005849
type: LocalParameter
value: 0.0

005813
type: SpeciesReference
stoichiometry: 1.0
species: 982077

984974
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: (S)-3-Hydroxybutyryl-CoA

019118
type: Reaction
product: 019154
reactant: 019142
kinetic law: 019178
name: Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial
reactant: 019130
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
product: 019166

019154
type: SpeciesReference
stoichiometry: 1.0
species: 982040

019142
type: SpeciesReference
stoichiometry: 1.0
species: 985450

019227
type: LocalParameter
value: 0.0

019215
type: LocalParameter
value: 0.0

019203
type: LocalParameter
value: 1000.0

019190
type: LocalParameter
value: -1000.0

019130
type: SpeciesReference
stoichiometry: 1.0
species: 984142

019166
type: SpeciesReference
stoichiometry: 1.0
species: 986475

034349
type: Reaction
reactant: 034399
reactant: 034386
fast: false
reactant: 034411
product: 034423
product: 034460
product: 034448
name: Beta oxidation of fatty acid
reversible: false
product: 034436
kinetic law: 034472
reactant: 034362
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
reactant: 034374

034399
type: SpeciesReference
stoichiometry: 10.0
species: 985848

034386
type: SpeciesReference
stoichiometry: 4.0
species: 985632

034411
type: SpeciesReference
stoichiometry: 10.0
species: 986150

034423
type: SpeciesReference
stoichiometry: 11.0
species: 985169

034460
type: SpeciesReference
stoichiometry: 10.0
species: 986162

034448
type: SpeciesReference
stoichiometry: 10.0
species: 985836

034436
type: SpeciesReference
stoichiometry: 4.0
species: 985644

034520
type: LocalParameter
value: 500.0

034508
type: LocalParameter
value: 0.0

034496
type: LocalParameter
value: 1000.0

034484
type: LocalParameter
value: 0.0

034362
type: SpeciesReference
stoichiometry: 10.0
species: 985413

034374
type: SpeciesReference
stoichiometry: 1.0
species: 985498

985498
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: docosahexaenoyl-CoA (C22:6CoA, n-3)

052635
type: Reaction
reversible: true
name: L-lactate dehydrogenase
fast: false
product: 052683
product: 052671
notes: GENE_ASSOCIATION: (NM_002300.3 or (NM_002300.3 and NM_005566.1) or NM_005566.1 or NM_144972.3 or NM_002301.2 or NM_033195.1 or NM_018314.2 or NM_017448.1) GENE_LIST: NM_002300.3 NM_002301.2 NM_005566.1 NM_017448.1 NM_018314.2 NM_033195.1 NM_144972.3 SUBSYSTEM: Pyruvate Metabolism
kinetic law: 052707
product: 052695
reactant: 052659
reactant: 052647

052683
type: SpeciesReference
stoichiometry: 1.0
species: 983661

052671
type: SpeciesReference
stoichiometry: 1.0
species: 983066

052755
type: LocalParameter
value: 0.0

052743
type: LocalParameter
value: 0.0

052731
type: LocalParameter
value: 1000.0

052719
type: LocalParameter
value: -1000.0

052695
type: SpeciesReference
stoichiometry: 1.0
species: 984346

052659
type: SpeciesReference
stoichiometry: 1.0
species: 983649

052647
type: SpeciesReference
stoichiometry: 1.0
species: 983359

048089
type: Reaction
fast: false
name: bicarbonate transport (Na/HCO3 cotransport), blood
reactant: 048102
reversible: true
product: 048126
notes: GENE_ASSOCIATION: (NM_001098484.1 or NM_003615.2 or NM_133478.1 or NM_021196.2 or NM_003759.1) GENE_LIST: NM_001098484.1 NM_003615.2 NM_003759.1 NM_021196.2 NM_133478.1 SUBSYSTEM: Transport, Extracellular
reactant: 048114
product: 048138
kinetic law: 048150

048102
type: SpeciesReference
stoichiometry: 1.0
species: 980459

048126
type: SpeciesReference
stoichiometry: 1.0
species: 983102

048114
type: SpeciesReference
stoichiometry: 1.0
species: 980605

048138
type: SpeciesReference
stoichiometry: 1.0
species: 983637

048198
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value: 0.0

048186
type: LocalParameter
value: 0.0

048174
type: LocalParameter
value: 1000.0

048162
type: LocalParameter
value: -1000.0

081883
type: Reaction
kinetic law: 081919
product: 081907
reactant: 081895
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Valine transport, Homo Sapiens passive diffusion

081967
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value: 0.0

081955
type: LocalParameter
value: 0.0

081943
type: LocalParameter
value: 1000.0

081931
type: LocalParameter
value: -1000.0

081907
type: SpeciesReference
stoichiometry: 1.0
species: 986765

986765
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Valine

081895
type: SpeciesReference
stoichiometry: 1.0
species: 984805

004636
type: Reaction
product: 004685
reactant: 004661
reversible: false
kinetic law: 004709
product: 004673
notes: GENE_ASSOCIATION: NM_000672.2 GENE_LIST: NM_000672.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 004649
product: 004697
name: alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
fast: false

004685
type: SpeciesReference
stoichiometry: 1.0
species: 983066

004661
type: SpeciesReference
stoichiometry: 1.0
species: 983649

004758
type: LocalParameter
value: 500.0

004746
type: LocalParameter
value: 0.0

004733
type: LocalParameter
value: 1000.0

004721
type: LocalParameter
value: 0.0

004673
type: SpeciesReference
stoichiometry: 1.0
species: 981484

004649
type: SpeciesReference
stoichiometry: 1.0
species: 982595

004697
type: SpeciesReference
stoichiometry: 1.0
species: 983661

007007
type: Reaction
notes: GENE_ASSOCIATION: NM_001628.2 GENE_LIST: NM_001628.2 SUBSYSTEM: Fructose and Mannose Metabolism
reversible: true
product: 007056
name: aldehyde reductase (sorbitol: R01787)
reactant: 007032
reactant: 007044
product: 007068
kinetic law: 007080
reactant: 007019
fast: false

007056
type: SpeciesReference
stoichiometry: 1.0
species: 983673

007032
type: SpeciesReference
stoichiometry: 1.0
species: 983066

007044
type: SpeciesReference
stoichiometry: 1.0
species: 983685

007068
type: SpeciesReference
stoichiometry: 1.0
species: 984406

984406
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Sorbitol

007128
type: LocalParameter
value: 0.0

007116
type: LocalParameter
value: 0.0

007104
type: LocalParameter
value: 1000.0

007092
type: LocalParameter
value: -1000.0

007019
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species: 982885

985084
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 4-Methyl-2-oxopentanoate

010780
type: Reaction
kinetic law: 010828
product: 010816
reactant: 010804
reactant: 010792
notes: GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
fast: false
reversible: false
name: cysteine dioxygenase

010877
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value: 500.0

010865
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value: 0.0

010853
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value: 1000.0

010840
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value: 0.0

010816
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stoichiometry: 1.0
species: 981207

981207
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3-Sulfino-L-alanine

010804
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stoichiometry: 1.0
species: 983709

010792
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stoichiometry: 1.0
species: 982077

016079
type: Reaction
product: 016115
product: 016127
reactant: 016091
reversible: true
kinetic law: 016139
reactant: 016103
name: carnitine hexadecenoyltransferase (C16:1Crn, n7)
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1 or NM_152247.1 or NM_152246.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
fast: false

016115
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species: 981991

016127
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stoichiometry: 1.0
species: 983162

016091
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stoichiometry: 1.0
species: 982040

016187
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value: 0.0

016175
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value: 0.0

016163
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value: 1000.0

016151
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value: -1000.0

016103
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stoichiometry: 1.0
species: 983150

073051
type: Reaction
kinetic law: 073123
reversible: false
product: 073099
reactant: 073075
reactant: 073063
product: 073087
name: ribonucleoside-diphosphate reductase (CDP)
product: 073111
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Pyrimidine Metabolism
fast: false

073171
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value: 500.0

073159
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value: 0.0

073147
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value: 1000.0

073135
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value: 0.0

073099
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stoichiometry: 1.0
species: 983078

073075
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stoichiometry: 1.0
species: 984624

073063
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species: 981786

073087
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species: 982162

982162
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dCDP

073111
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species: 984612

987823
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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: glc_D_b

038236
type: Reaction
kinetic law: 038272
product: 038260
reactant: 038248
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: formate transport via diffusion

038320
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038308
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value: 0.0

038296
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value: 1000.0

038284
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038260
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stoichiometry: 1.0
species: 986959

038248
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stoichiometry: 1.0
species: 982740

989787
type: Reaction
kinetic law: 989823
product: 989811
reactant: 989799
fast: false
reversible: true
name: Acetate exchange

989871
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value: 500.0

989859
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value: 0.0

989847
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value: 1000.0

989835
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value: 0.0

989811
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species: 987473

987473
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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ac_b

989799
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stoichiometry: 1.0
species: 980022

024444
type: Reaction
reactant: 024468
reactant: 024492
product: 024528
product: 024516
kinetic law: 024540
reactant: 024456
name: Oleoyl-CoA desaturase (C18:2CoA, n6 -> C18:3CoA, n6)
notes: GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 024480
product: 024504
fast: false
reversible: false

024468
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stoichiometry: 1.0
species: 983685

024492
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stoichiometry: 1.0
species: 983793

024528
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stoichiometry: 1.0
species: 983841

024516
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stoichiometry: 1.0
species: 983673

024588
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value: 500.0

024576
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value: 0.0

024564
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value: 1000.0

024552
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value: 0.0

024456
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stoichiometry: 1.0
species: 983066

024480
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stoichiometry: 1.0
species: 983709

024504
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stoichiometry: 2.0
species: 983078

060836
type: Reaction
reactant: 060860
product: 060884
name: nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
reactant: 060848
kinetic law: 060896
product: 060872
fast: false
notes: GENE_ASSOCIATION: ((NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or NM_013330.3 or NM_002513.2 or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_005793.3 or NM_197972.1 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018138.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Purine Metabolism

060860
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species: 982113

060884
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species: 982125

060848
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species: 981738

060944
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value: 0.0

060932
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value: 0.0

060920
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value: 1000.0

060908
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value: -1000.0

060872
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stoichiometry: 1.0
species: 981557

062431
type: Reaction
kinetic law: 062467
product: 062455
reactant: 062443
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecanoate (n-C18:0) transport in via uniport

062517
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value: 0.0

062504
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value: 0.0

062491
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value: 1000.0

062479
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value: -1000.0

062455
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stoichiometry: 1.0
species: 980642

980642
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: octadecanoate (n-C18:0)

062443
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stoichiometry: 1.0
species: 983745

995697
type: Reaction
kinetic law: 995733
product: 995721
reactant: 995709
fast: false
reversible: true
name: (R)-Pantothenate exchange

995781
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value: 500.0

995769
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value: 0.0

995757
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value: 1000.0

995745
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value: 0.0

995721
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stoichiometry: 1.0
species: 988211

995709
type: SpeciesReference
stoichiometry: 1.0
species: 980770

989883
type: Reaction
kinetic law: 989920
product: 989908
reactant: 989896
fast: false
reversible: true
name: Acetoacetate exchange

989969
type: LocalParameter
value: 500.0

989957
type: LocalParameter
value: 0.0

989944
type: LocalParameter
value: 1000.0

989932
type: LocalParameter
value: 0.0

989908
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stoichiometry: 1.0
species: 987485

989896
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stoichiometry: 1.0
species: 980034

980034
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Acetoacetate

981641
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: S-Adenosyl-L-methionine

995793
type: Reaction
kinetic law: 995829
product: 995817
reactant: 995805
fast: false
reversible: true
name: L-Proline exchange

995877
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value: 500.0

995865
type: LocalParameter
value: 0.0

995853
type: LocalParameter
value: 1000.0

995841
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value: 0.0

995817
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stoichiometry: 1.0
species: 988223

988223
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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: pro_L_b

995805
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stoichiometry: 1.0
species: 980782

980782
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Proline

036043
type: Reaction
product: 036129
reactant: 036080
reversible: false
fast: false
reactant: 036055
product: 036104
kinetic law: 036165
product: 036141
reactant: 036092
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
name: fatty acid synthase (n-C14:0)
product: 036153
product: 036116
reactant: 036067

036129
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stoichiometry: 1.0
species: 983078

036080
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stoichiometry: 1.0
species: 983419

036055
type: SpeciesReference
stoichiometry: 1.0
species: 982246

036104
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stoichiometry: 1.0
species: 981979

036215
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value: 500.0

036203
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value: 0.0

036190
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value: 1000.0

036177
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036141
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stoichiometry: 2.0
species: 983673

036092
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stoichiometry: 2.0
species: 983685

036153
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stoichiometry: 1.0
species: 984684

036116
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stoichiometry: 1.0
species: 981991

036067
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stoichiometry: 3.0
species: 983066

984106
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: phosphatidyl-1D-myo-inositol, human hepatocyte

035486
type: Reaction
reactant: 035534
reactant: 035510
kinetic law: 035619
product: 035571
reactant: 035522
reversible: false
product: 035607
product: 035595
fast: false
reactant: 035498
product: 035583
reactant: 035546
product: 035559
name: Beta oxidation of odd chain fatty acid
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation

035534
type: SpeciesReference
stoichiometry: 1.0
species: 986150

035510
type: SpeciesReference
stoichiometry: 1.0
species: 985632

035667
type: LocalParameter
value: 500.0

035655
type: LocalParameter
value: 0.0

035643
type: LocalParameter
value: 1000.0

035631
type: LocalParameter
value: 0.0

035571
type: SpeciesReference
stoichiometry: 1.0
species: 985644

035522
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stoichiometry: 1.0
species: 985848

035607
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stoichiometry: 1.0
species: 986162

035595
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stoichiometry: 1.0
species: 985933

035498
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stoichiometry: 1.0
species: 985413

035583
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stoichiometry: 1.0
species: 985836

035546
type: SpeciesReference
stoichiometry: 1.0
species: 986210

986210
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: nonanoyl-CoA (C9:0CoA)

035559
type: SpeciesReference
stoichiometry: 1.0
species: 985169

011420
type: Reaction
notes: GENE_ASSOCIATION: (NM_005017.2 or NM_004845.3) GENE_LIST: NM_004845.3 NM_005017.2 SUBSYSTEM: Phospholipid Metabolism
reversible: false
product: 011481
reactant: 011457
product: 011469
kinetic law: 011493
name: choline phosphate cytididyltransferase
reactant: 011432
reactant: 011445
fast: false

011481
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stoichiometry: 1.0
species: 984202

011457
type: SpeciesReference
stoichiometry: 1.0
species: 983066

011469
type: SpeciesReference
stoichiometry: 1.0
species: 981798

011541
type: LocalParameter
value: 500.0

011529
type: LocalParameter
value: 0.0

011517
type: LocalParameter
value: 1000.0

011505
type: LocalParameter
value: 0.0

011432
type: SpeciesReference
stoichiometry: 1.0
species: 981870

011445
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stoichiometry: 1.0
species: 982064

982499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Erythrose 4-phosphate

051910
type: Reaction
reactant: 051934
reversible: true
product: 051970
product: 051994
fast: false
reactant: 051946
name: kynurenine 3-monooxygenase
reactant: 051958
product: 051982
notes: GENE_ASSOCIATION: NM_003679.2 GENE_LIST: NM_003679.2 SUBSYSTEM: Tryptophan metabolism
kinetic law: 052007
reactant: 051922

051934
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species: 983334

051970
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species: 983078

051994
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species: 983673

051946
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species: 983685

051958
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species: 983709

051982
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species: 983198

052055
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052043
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052031
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value: 1000.0

052019
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value: -1000.0

051922
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stoichiometry: 1.0
species: 983066

079324
type: Reaction
kinetic law: 079360
product: 079348
reactant: 079336
notes: GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: triose-phosphate isomerase

079408
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value: 0.0

079396
type: LocalParameter
value: 0.0

079384
type: LocalParameter
value: 1000.0

079372
type: LocalParameter
value: -1000.0

079348
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stoichiometry: 1.0
species: 982836

079336
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stoichiometry: 1.0
species: 982294

986911
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 7-Dehydrodesmosterol

063808
type: Reaction
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
product: 063856
reactant: 063820
reactant: 063832
product: 063868
kinetic law: 063892
product: 063880
reactant: 063844
fast: false
reversible: false
notes: GENE_ASSOCIATION: (NM_170726.1 or NM_003748.2) GENE_LIST: NM_003748.2 NM_170726.1 SUBSYSTEM: Glutamate metabolism

063856
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stoichiometry: 1.0
species: 985752

063820
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species: 984854

063832
type: SpeciesReference
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species: 985848

063868
type: SpeciesReference
stoichiometry: 1.0
species: 985836

063940
type: LocalParameter
value: 500.0

063928
type: LocalParameter
value: 0.0

063916
type: LocalParameter
value: 1000.0

063904
type: LocalParameter
value: 0.0

063880
type: SpeciesReference
stoichiometry: 1.0
species: 986162

063844
type: SpeciesReference
stoichiometry: 1.0
species: 986150

025624
type: Reaction
fast: false
reactant: 025660
notes: GENE_ASSOCIATION: NM_000791.3 GENE_LIST: NM_000791.3 SUBSYSTEM: Folate Metabolism
product: 025684
kinetic law: 025696
reactant: 025636
product: 025672
reactant: 025648
name: dihydrofolate reductase
reversible: true

025660
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species: 983685

025684
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stoichiometry: 1.0
species: 984576

025744
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value: 0.0

025732
type: LocalParameter
value: 0.0

025720
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value: 1000.0

025708
type: LocalParameter
value: -1000.0

025636
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stoichiometry: 1.0
species: 982319

982319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 7,8-Dihydrofolate

025672
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stoichiometry: 1.0
species: 983673

025648
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stoichiometry: 1.0
species: 983066

992017
type: Reaction
kinetic law: 992053
product: 992041
reactant: 992029
fast: false
reversible: true
name: eicosatetraenoate (C20:4, n-3) exchange

992102
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value: 500.0

992090
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value: 0.0

992078
type: LocalParameter
value: 1000.0

992066
type: LocalParameter
value: 0.0

992041
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stoichiometry: 1.0
species: 987750

992029
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stoichiometry: 1.0
species: 980301

980301
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: eicosatetraenoate (C20:4, n-3)

980241
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: Eicosanoate (n-C20:0)

001006
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reactant: 001030
product: 001066
reactant: 001018
fast: false
reversible: false
notes: GENE_ASSOCIATION: (NM_203488.1 or NM_138448.2 or NM_001107.3) GENE_LIST: NM_001107.3 NM_138448.2 NM_203488.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 001054
product: 001042
name: acylphosphatase
kinetic law: 001078

001030
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stoichiometry: 1.0
species: 983078

001066
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species: 984094

001018
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species: 980966

001054
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species: 983066

001042
type: SpeciesReference
stoichiometry: 1.0
species: 981183

001126
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value: 500.0

001114
type: LocalParameter
value: 0.0

001102
type: LocalParameter
value: 1000.0

001090
type: LocalParameter
value: 0.0

021332
type: Reaction
name: L-cysteine/L-threonine exchange, blood
fast: false
product: 021380
reversible: true
reactant: 021344
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
reactant: 021356
kinetic law: 021392
product: 021368

021380
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stoichiometry: 1.0
species: 982077

021344
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stoichiometry: 1.0
species: 980180

021356
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species: 984588

021441
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value: 0.0

021429
type: LocalParameter
value: 0.0

021417
type: LocalParameter
value: 1000.0

021405
type: LocalParameter
value: -1000.0

021368
type: SpeciesReference
stoichiometry: 1.0
species: 980843

012428
type: Reaction
kinetic law: 012464
product: 012452
reactant: 012440
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: cholestenol delta-isomerase

012513
type: LocalParameter
value: 0.0

012500
type: LocalParameter
value: 0.0

012488
type: LocalParameter
value: 1000.0

012476
type: LocalParameter
value: -1000.0

012452
type: SpeciesReference
stoichiometry: 1.0
species: 986875

012440
type: SpeciesReference
stoichiometry: 1.0
species: 987230

987230
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: Zymosterol

059873
type: Reaction
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notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Citric Acid Cycle
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reversible: true
product: 059921
product: 059909

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016440
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kinetic law: 016501
product: 016488
reactant: 016464
reversible: true
fast: false
name: carnitine pentadecanoyltransferase (C17:0Crn)
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_152359.1 or NM_001876.2 or NM_152246.1 or NM_152245.1 or NM_004377.2 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 016476

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species: 982040

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name: heptadecanoyl carnitine (C17:0Crn)

016464
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016476
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008943
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product: 008991
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notes: SUBSYSTEM: Transport, Extracellular
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069393
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product: 069441
product: 069453
kinetic law: 069489
reactant: 069429
notes: GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Anaplerotic reactions
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reversible: true
reactant: 069417
reactant: 069405
product: 069465
product: 069477

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000393
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product: 000429
reactant: 000417
reversible: false
notes: SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 000441
product: 000453
name: acetyl-CoA hydrolase, mitochondrial
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041918
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notes: GENE_ASSOCIATION: (NM_148918.1 or NM_004169.3) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Glycine and Serine Metabolism
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reactant: 041930
product: 041966
name: glycine hydroxymethyltransferase
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product: 041954

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991436
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product: 991460
reactant: 991448
fast: false
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990856
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product: 990880
reactant: 990868
fast: false
reversible: true
name: L-Carnitine exchange

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999776
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product: 999812
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notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Leucine degradation
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reactant: 999788
product: 999824
reactant: 999800
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initial concentration: NaN
initial amount: NaN
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name: 3-Methylbut-2-enoyl-CoA

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999873
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999861
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species: 985632

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initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Isovaleryl-CoA

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initial amount: NaN
in compartment: 979972
name: docosapentaenoate (C22:5, n-6)

998012
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reactant: 998025
notes: GENE_ASSOCIATION: NM_003734.2 GENE_LIST: NM_003734.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 998085
product: 998061
kinetic law: 998097
name: Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
product: 998073
reactant: 998049
reversible: false
reactant: 998037

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021963
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name: cytidylate kinase (CMP)
reactant: 021975
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notes: GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Pyrimidine Metabolism
product: 021999
reactant: 021987
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product: 022011
kinetic law: 022023

021975
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species: 981738

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022011
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022059
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022047
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022035
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063060
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product: 063109
kinetic law: 063145
product: 063121
product: 063133
name: Ornithine/citrulline antiport, mitocondiral
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reactant: 063073
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notes: GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial

063109
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species: 981931

063194
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063182
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063170
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063158
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species: 983066

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species: 986343

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species: 983890

063085
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species: 985364

063097
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995985
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kinetic law: 996021
product: 996009
reactant: 995997
fast: false
reversible: true
name: Pyruvate exchange

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species: 988247

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initial concentration: NaN
initial amount: NaN
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987979
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in compartment: 979985
name: lac_D_b

057264
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product: 057288
reactant: 057276
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Methylmalonate transport, mitochondrial

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057324
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057288
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species: 983541

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initial concentration: NaN
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name: Methylmalonate

057276
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045283
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reactant: 045295
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notes: GENE_ASSOCIATION: (NM_001040427.1 or NM_005326.4 or NM_207112.1 or NM_032304.2) GENE_LIST: NM_001040427.1 NM_005326.4 NM_032304.2 NM_207112.1 SUBSYSTEM: Glutathione Metabolism
product: 045332
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045344
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species: 983346

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constant: false
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045332
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001600
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product: 001648
fast: false
product: 001636
reactant: 001612
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notes: GENE_ASSOCIATION: (NM_001634.4 or NM_001033059.1) GENE_LIST: NM_001033059.1 NM_001634.4 SUBSYSTEM: Arginine Metabolism
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001648
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species: 981979

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species: 981653

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constant: false
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initial concentration: NaN
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name: S-Adenosylmethioninamine

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species: 981641

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001696
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001684
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001672
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001624
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species: 983066

009898
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notes: GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
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reactant: 009934
product: 009970
product: 009983
name: C-4 methyl sterol oxidase NADH
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kinetic law: 009995

009946
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species: 986899

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species: 987069

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initial concentration: NaN
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name: Nicotinamide adenine dinucleotide

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species: 987021

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species: 987117

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species: 987081

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initial concentration: NaN
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name: Nicotinamide adenine dinucleotide - reduced

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species: 987217

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species: 986814

010044
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010032
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010019
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010007
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017409
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notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
reactant: 017433
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product: 017457
reactant: 017421
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product: 017445
name: octadecadienoyl carnitine transferase (C18:2Crn, n6)
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017433
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species: 985450

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species: 986282

986282
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constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: octadecadienoyl carnitine (C18:2Crn, n-6)

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species: 983805

983805
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: octadecadienoyl carnitine (C18:2Crn, n-6)

017518
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value: 0.0

017505
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value: 0.0

017493
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value: 1000.0

017481
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017445
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species: 982040

990078
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kinetic law: 990115
product: 990103
reactant: 990090
fast: false
reversible: true
name: L-Arginine exchange

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990151
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990139
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value: 1000.0

990127
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species: 987509

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constant: false
boundary condition: true
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initial concentration: NaN
initial amount: NaN
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name: arg_L_b

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species: 980058

075733
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fast: false
reactant: 075745
product: 075782
reactant: 075757
product: 075794
name: spermidine synthase
kinetic law: 075806
reversible: false
product: 075770
notes: GENE_ASSOCIATION: NM_003132.2 GENE_LIST: NM_003132.2 SUBSYSTEM: Arginine Metabolism

075745
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species: 981653

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species: 983066

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species: 984334

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species: 984479

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species: 981351

985474
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name: Decanoyl-CoA (C10:0CoA)

028899
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reactant: 028935
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reactant: 028923
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product: 028947
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product: 028959
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notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203379.1 or NM_001009185.1 or NM_203372.1 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
product: 028971

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species: 983757

029031
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029019
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029007
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value: 1000.0

028995
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species: 981991

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species: 981666

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initial concentration: NaN
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028911
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species: 981738

028971
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species: 984202

071954
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notes: GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Metabolism
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fast: false
product: 071991
reactant: 071966
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kinetic law: 072015

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species: 983974

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species: 981858

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072039
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072027
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985340
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initial amount: NaN
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name: CDPdiacylglycerol, human myocyte

081413
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notes: GENE_ASSOCIATION: (NM_012474.3 or NM_031432.1) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
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product: 081449
product: 081461
fast: false
name: uridine kinase (GTP:Uridine)
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reactant: 081437

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species: 983054

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species: 982873

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species: 983066

081437
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species: 984781

984781
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Uridine

980495
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Histidine

070224
type: Reaction
product: 070273
fast: false
reactant: 070260
kinetic law: 070321
reactant: 070236
reversible: false
product: 070297
reactant: 070248
notes: GENE_ASSOCIATION: (NM_175085.1 or NM_000819.3) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine Metabolism
name: phosphoribosylglycinamide synthetase
product: 070285
product: 070309

070273
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stoichiometry: 1.0
species: 981557

070260
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stoichiometry: 1.0
species: 984250

984250
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 5-Phospho-beta-D-ribosylamine

070370
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value: 500.0

070357
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value: 0.0

070345
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value: 1000.0

070333
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value: 0.0

070236
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stoichiometry: 1.0
species: 981738

070297
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species: 983066

070248
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species: 982945

070285
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species: 982861

070309
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species: 984094

021830
type: Reaction
name: cytidine kinase (ATP)
product: 021879
notes: GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
fast: false
reversible: false
product: 021891
kinetic law: 021903
reactant: 021843
reactant: 021855
product: 021867

021879
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species: 981967

021891
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species: 983066

021951
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021939
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021927
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value: 1000.0

021915
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021843
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species: 981738

021855
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species: 982101

982101
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Cytidine

021867
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species: 981557

987701
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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecsea9_b

073414
type: Reaction
kinetic law: 073450
product: 073438
reactant: 073426
notes: SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase, endoplasmic reticulum

073498
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value: 0.0

073486
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value: 0.0

073474
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value: 1000.0

073462
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value: -1000.0

073438
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stoichiometry: 1.0
species: 987204

073426
type: SpeciesReference
stoichiometry: 1.0
species: 987165

987165
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: D-Ribulose 5-phosphate

059753
type: Reaction
reactant: 059765
product: 059789
kinetic law: 059813
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018138.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or NM_013330.3 or NM_002513.2 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_197972.1 or (NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or NM_005793.3 or (NM_002512.2 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Purine Metabolism
name: nucleoside-diphosphate kinase (ATP:GDP)
reversible: true
fast: false
product: 059801
reactant: 059777

059765
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species: 981738

059789
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stoichiometry: 1.0
species: 981557

059861
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value: 0.0

059849
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value: 0.0

059837
type: LocalParameter
value: 1000.0

059825
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value: -1000.0

059801
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stoichiometry: 1.0
species: 983054

059777
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stoichiometry: 1.0
species: 982873

989594
type: Reaction
kinetic law: 989631
product: 989618
reactant: 989606
fast: false
reversible: true
name: (R)-3-Hydroxybutanoate exchange

989679
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value: 500.0

989667
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value: 0.0

989655
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value: 1000.0

989643
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value: 0.0

989618
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stoichiometry: 1.0
species: 987449

987449
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: 3hbut_R_b

989606
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stoichiometry: 1.0
species: 979997

055758
type: Reaction
kinetic law: 055830
notes: GENE_ASSOCIATION: (NM_002396.3 or NM_001014811.1 or NM_006680.2) GENE_LIST: NM_001014811.1 NM_002396.3 NM_006680.2 SUBSYSTEM: Aspartate Degradation
reactant: 055770
product: 055818
product: 055806
fast: false
reversible: true
name: malic enzyme (NADP)
reactant: 055782
product: 055794

055878
type: LocalParameter
value: 0.0

055866
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value: 0.0

055854
type: LocalParameter
value: 1000.0

055842
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value: -1000.0

055770
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stoichiometry: 1.0
species: 986066

055818
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stoichiometry: 1.0
species: 986572

055806
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stoichiometry: 1.0
species: 986186

055782
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stoichiometry: 1.0
species: 986174

055794
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stoichiometry: 1.0
species: 985400

034168
type: Reaction
reactant: 034216
fast: false
product: 034264
reversible: false
reactant: 034204
product: 034240
reactant: 034192
name: Beta oxidation of fatty acid
reactant: 034228
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
kinetic law: 034288
product: 034276
product: 034252
reactant: 034180

034216
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stoichiometry: 10.0
species: 985848

034264
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stoichiometry: 10.0
species: 985836

034204
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stoichiometry: 5.0
species: 985632

034240
type: SpeciesReference
stoichiometry: 11.0
species: 985169

034192
type: SpeciesReference
stoichiometry: 1.0
species: 985523

985523
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: docosapentaenoyl-CoA (C22:5CoA, n-3)

034228
type: SpeciesReference
stoichiometry: 10.0
species: 986150

034337
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value: 500.0

034325
type: LocalParameter
value: 0.0

034313
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value: 1000.0

034300
type: LocalParameter
value: 0.0

034276
type: SpeciesReference
stoichiometry: 10.0
species: 986162

034252
type: SpeciesReference
stoichiometry: 5.0
species: 985644

034180
type: SpeciesReference
stoichiometry: 10.0
species: 985413

059489
type: Reaction
product: 059525
kinetic law: 059561
name: nucleoside-diphosphatase (dCDP)
notes: GENE_ASSOCIATION: NM_004901.1 GENE_LIST: NM_004901.1 SUBSYSTEM: Pyrimidine Metabolism
reactant: 059501
product: 059549
reversible: false
reactant: 059513
product: 059537
fast: false

059525
type: SpeciesReference
stoichiometry: 1.0
species: 982186

059609
type: LocalParameter
value: 500.0

059597
type: LocalParameter
value: 0.0

059585
type: LocalParameter
value: 1000.0

059573
type: LocalParameter
value: 0.0

059501
type: SpeciesReference
stoichiometry: 1.0
species: 982162

059549
type: SpeciesReference
stoichiometry: 1.0
species: 984094

059513
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species: 983078

059537
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species: 983066

078132
type: Reaction
kinetic law: 078180
product: 078168
product: 078156
reactant: 078144
notes: SUBSYSTEM: Threonine Degradation
fast: false
reversible: true
name: threonine aldolase

078228
type: LocalParameter
value: 0.0

078216
type: LocalParameter
value: 0.0

078204
type: LocalParameter
value: 1000.0

078192
type: LocalParameter
value: -1000.0

078168
type: SpeciesReference
stoichiometry: 1.0
species: 982945

078156
type: SpeciesReference
stoichiometry: 1.0
species: 981484

078144
type: SpeciesReference
stoichiometry: 1.0
species: 984588

062006
type: Reaction
kinetic law: 062042
product: 062030
reactant: 062018
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: O2 transport in via diffusion

062090
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value: 0.0

062078
type: LocalParameter
value: 0.0

062066
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value: 1000.0

062054
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062030
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stoichiometry: 1.0
species: 983709

062018
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stoichiometry: 1.0
species: 980629

980629
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: O2

013348
type: Reaction
kinetic law: 013384
product: 013372
reactant: 013360
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: CO2 peroxisomal transport

013432
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value: 0.0

013420
type: LocalParameter
value: 0.0

013408
type: LocalParameter
value: 1000.0

013396
type: LocalParameter
value: -1000.0

013372
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stoichiometry: 1.0
species: 987305

013360
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stoichiometry: 1.0
species: 981979

985328
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: CDP

044295
type: Reaction
product: 044343
notes: GENE_ASSOCIATION: (NM_024698.4 or NM_031481.1) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
fast: false
reactant: 044307
name: L-glutamate reversible transport via proton symport, mitochondrial
product: 044331
reversible: true
reactant: 044319
kinetic law: 044355

044343
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stoichiometry: 1.0
species: 985836

044307
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stoichiometry: 1.0
species: 982909

044331
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species: 985752

044319
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species: 983066

044403
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044391
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044379
type: LocalParameter
value: 1000.0

044367
type: LocalParameter
value: -1000.0

053584
type: Reaction
product: 053669
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
product: 053644
reversible: false
kinetic law: 053681
product: 053656
reactant: 053608
name: Lathosterol oxidase
reactant: 053620
reactant: 053632
reactant: 053596
fast: false

053669
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species: 987093

053644
type: SpeciesReference
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species: 986911

053729
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053717
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053705
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value: 1000.0

053693
type: LocalParameter
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053656
type: SpeciesReference
stoichiometry: 2.0
species: 987033

053608
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species: 987021

053620
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species: 987105

053632
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species: 987117

053596
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species: 986875

055360
type: Reaction
reactant: 055384
reversible: true
kinetic law: 055432
name: malate dehydrogenase, mitochondrial
product: 055396
fast: false
product: 055408
reactant: 055372
notes: GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citric Acid Cycle
product: 055420

055384
type: SpeciesReference
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species: 986150

055480
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055468
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055456
type: LocalParameter
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055444
type: LocalParameter
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055396
type: SpeciesReference
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species: 985836

055408
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species: 986162

055372
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species: 986066

055420
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species: 986246

041373
type: Reaction
reactant: 041543
kinetic law: 041592
reversible: false
notes: GENE_ASSOCIATION: (NM_020918.2 or NM_032717.3) GENE_LIST: NM_020918.2 NM_032717.3 SUBSYSTEM: Phospholipid Metabolism
reactant: 041507
reactant: 041471
reactant: 041410
reactant: 041434
reactant: 041495
name: glycerol 3-phosphate acyltransferase, myocyte specific
product: 041567
reactant: 041447
reactant: 041555
fast: false
reactant: 041531
reactant: 041398
reactant: 041386
reactant: 041422
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product: 041580
reactant: 041459
reactant: 041483

041543
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species: 984504

041640
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041628
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041616
type: LocalParameter
value: 1000.0

041604
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041507
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stoichiometry: 0.106
species: 983865

041471
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species: 983247

041410
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species: 982547

041434
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stoichiometry: 0.119
species: 982619

041495
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species: 983829

041567
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species: 980978

041447
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species: 982969

041555
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species: 984540

041531
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species: 984130

041398
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species: 982391

041386
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041422
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species: 982571

041519
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species: 983998

983998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: pentadecanoyl-CoA (C15:0CoA)

041580
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species: 981991

041459
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species: 983150

041483
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species: 983793

991241
type: Reaction
kinetic law: 991277
product: 991265
reactant: 991253
fast: false
reversible: true
name: docosapentaenoate (C22:5, n-3) exchange

991326
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991313
type: LocalParameter
value: 0.0

991301
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value: 1000.0

991289
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991265
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stoichiometry: 1.0
species: 987653

987653
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: dcspea3_b

991253
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species: 980204

055890
type: Reaction
reactant: 055902
kinetic law: 055974
product: 055962
product: 055950
name: methionine adenosyltransferase
reactant: 055926
reversible: false
reactant: 055914
fast: false
notes: GENE_ASSOCIATION: ((NM_005911.4 and NM_013283.3) or (NM_005911.4 and NM_182796.1) or NM_000429.2) GENE_LIST: NM_000429.2 NM_005911.4 NM_013283.3 NM_182796.1 SUBSYSTEM: Methionine Metabolism
product: 055938

055902
type: SpeciesReference
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species: 981738

056022
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value: 500.0

056010
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055998
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value: 1000.0

055986
type: LocalParameter
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055962
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stoichiometry: 1.0
species: 984202

055950
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species: 984094

055926
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species: 983468

055914
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species: 983078

055938
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species: 981641

040683
type: Reaction
reversible: true
kinetic law: 040755
product: 040719
reactant: 040695
fast: false
notes: GENE_ASSOCIATION: (NM_000156.4 or NM_138924.1) GENE_LIST: NM_000156.4 NM_138924.1 SUBSYSTEM: Creatine Biosynthesis
product: 040731
product: 040743
name: guanidinoacetate N-methyltransferase
reactant: 040707

040803
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040791
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040779
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value: 1000.0

040767
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040719
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species: 981569

981569
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: S-Adenosyl-L-homocysteine

040695
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stoichiometry: 1.0
species: 981641

040731
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species: 982015

040743
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040707
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species: 982981

982981
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Glycocyamine

078831
type: Reaction
notes: GENE_ASSOCIATION: (NM_001064.1 or NM_012253.2 or NM_032136.3) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 078843
fast: false
kinetic law: 078891
product: 078867
reversible: true
reactant: 078855
product: 078879
name: transketolase

078843
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species: 982499

078939
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078927
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078915
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value: 1000.0

078903
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078867
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species: 982656

078855
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species: 984830

984830
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Xylulose 5-phosphate

078879
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species: 982836

043094
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reversible: false
reactant: 043106
name: glutamate 5-kinase, mitochondrial
notes: GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Glutamate Metabolism
fast: false
kinetic law: 043155
product: 043143
product: 043130
reactant: 043118

043106
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species: 985279

043203
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043191
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043179
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043167
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043143
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stoichiometry: 1.0
species: 985764

985764
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Glutamate 5-phosphate

043130
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species: 985195

043118
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species: 985752

028464
type: Reaction
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_022977.1 or NM_203379.1 or NM_203380.1 or NM_001009185.1 or NM_004457.3 or NM_016234.3 or NM_203372.1 or NM_004458.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
product: 028512
name: fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)
fast: false
product: 028524
reactant: 028476
reactant: 028488
reactant: 028500
kinetic law: 028549
product: 028536
reversible: true

028512
type: SpeciesReference
stoichiometry: 1.0
species: 981666

028524
type: SpeciesReference
stoichiometry: 1.0
species: 983150

028476
type: SpeciesReference
stoichiometry: 1.0
species: 981738

028488
type: SpeciesReference
stoichiometry: 1.0
species: 981991

028500
type: SpeciesReference
stoichiometry: 1.0
species: 983138

028597
type: LocalParameter
value: 0.0

028585
type: LocalParameter
value: 0.0

028573
type: LocalParameter
value: 1000.0

028561
type: LocalParameter
value: -1000.0

028536
type: SpeciesReference
stoichiometry: 1.0
species: 984202

995889
type: Reaction
kinetic law: 995925
product: 995913
reactant: 995901
fast: false
reversible: true
name: pentadecanoate (C15:0) exchange

995973
type: LocalParameter
value: 500.0

995961
type: LocalParameter
value: 0.0

995949
type: LocalParameter
value: 1000.0

995937
type: LocalParameter
value: 0.0

995913
type: SpeciesReference
stoichiometry: 1.0
species: 988235

995901
type: SpeciesReference
stoichiometry: 1.0
species: 980794

980794
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: pentadecanoate (C15:0)

991338
type: Reaction
kinetic law: 991375
product: 991363
reactant: 991350
fast: false
reversible: true
name: docosapentaenoate (C22:5, n-6) exchange

991423
type: LocalParameter
value: 500.0

991411
type: LocalParameter
value: 0.0

991399
type: LocalParameter
value: 1000.0

991387
type: LocalParameter
value: 0.0

991363
type: SpeciesReference
stoichiometry: 1.0
species: 987665

991350
type: SpeciesReference
stoichiometry: 1.0
species: 980216

026132
type: Reaction
kinetic law: 026193
product: 026168
product: 026180
notes: GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Metabolism
reactant: 026144
name: dimethylallyltranstransferase
reactant: 026156
fast: false
reversible: false

026241
type: LocalParameter
value: 500.0

026229
type: LocalParameter
value: 0.0

026217
type: LocalParameter
value: 1000.0

026205
type: LocalParameter
value: 0.0

026168
type: SpeciesReference
stoichiometry: 1.0
species: 983017

983017
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Geranyl diphosphate

026180
type: SpeciesReference
stoichiometry: 1.0
species: 984202

026144
type: SpeciesReference
stoichiometry: 1.0
species: 982343

026156
type: SpeciesReference
stoichiometry: 1.0
species: 983322

050050
type: Reaction
kinetic law: 050087
product: 050075
reactant: 050062
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion, blood

050136
type: LocalParameter
value: 0.0

050124
type: LocalParameter
value: 0.0

050111
type: LocalParameter
value: 1000.0

050099
type: LocalParameter
value: -1000.0

050075
type: SpeciesReference
stoichiometry: 1.0
species: 983234

050062
type: SpeciesReference
stoichiometry: 1.0
species: 980507

079965
type: Reaction
kinetic law: 080013
product: 080001
reactant: 079989
reactant: 079977
notes: GENE_ASSOCIATION: NM_005651.1 GENE_LIST: NM_005651.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: false
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

080062
type: LocalParameter
value: 500.0

080050
type: LocalParameter
value: 0.0

080038
type: LocalParameter
value: 1000.0

080026
type: LocalParameter
value: 0.0

080001
type: SpeciesReference
stoichiometry: 1.0
species: 981423

079989
type: SpeciesReference
stoichiometry: 1.0
species: 984660

079977
type: SpeciesReference
stoichiometry: 1.0
species: 983709

987871
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: glyc_b

014171
type: Reaction
kinetic law: 014207
product: 014195
reactant: 014183
notes: SUBSYSTEM: Creatine Biosynthesis
fast: false
reversible: false
name: Creatine transport to/from mitochondria via diffusion

014255
type: LocalParameter
value: 500.0

014243
type: LocalParameter
value: 0.0

014231
type: LocalParameter
value: 1000.0

014219
type: LocalParameter
value: 0.0

014195
type: SpeciesReference
stoichiometry: 1.0
species: 985426

985426
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Creatine

014183
type: SpeciesReference
stoichiometry: 1.0
species: 982015

023126
type: Reaction
kinetic law: 023186
fast: false
reactant: 023150
name: diacylglycerol pyrophosphate phosphatase, human myocyte
reactant: 023138
product: 023162
reversible: false
notes: GENE_ASSOCIATION: (NM_003713.3 or NM_177526.1 or NM_003711.2 or NM_177414.1 or NM_176895.1 or NM_003712.2 or NM_177543.1) GENE_LIST: NM_003711.2 NM_003712.2 NM_003713.3 NM_176895.1 NM_177414.1 NM_177526.1 NM_177543.1 SUBSYSTEM: Phospholipid Metabolism
product: 023174

023235
type: LocalParameter
value: 500.0

023223
type: LocalParameter
value: 0.0

023211
type: LocalParameter
value: 1000.0

023199
type: LocalParameter
value: 0.0

023150
type: SpeciesReference
stoichiometry: 0.001
species: 983938

023138
type: SpeciesReference
stoichiometry: 1.0
species: 983078

023162
type: SpeciesReference
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species: 980954

023174
type: SpeciesReference
stoichiometry: 1.0
species: 984094

038659
type: Reaction
notes: GENE_ASSOCIATION: (NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
product: 038732
reactant: 038696
product: 038708
reactant: 038671
reversible: true
fast: false
reactant: 038683
name: formate-tetrahydrofolate ligase, mitochondrial
product: 038720
kinetic law: 038744

038732
type: SpeciesReference
stoichiometry: 1.0
species: 986451

038696
type: SpeciesReference
stoichiometry: 1.0
species: 986717

038708
type: SpeciesReference
stoichiometry: 1.0
species: 984842

984842
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 10-Formyltetrahydrofolate

038671
type: SpeciesReference
stoichiometry: 1.0
species: 985279

038683
type: SpeciesReference
stoichiometry: 1.0
species: 985704

038720
type: SpeciesReference
stoichiometry: 1.0
species: 985195

038792
type: LocalParameter
value: 0.0

038780
type: LocalParameter
value: 0.0

038768
type: LocalParameter
value: 1000.0

038756
type: LocalParameter
value: -1000.0

074357
type: Reaction
product: 074417
notes: GENE_ASSOCIATION: NM_007101.2 GENE_LIST: NM_007101.2 SUBSYSTEM: Glycine and Serine Metabolism
kinetic law: 074441
name: Sarcosine dehydrogenase (m)
reactant: 074381
product: 074405
reactant: 074369
product: 074429
reactant: 074393
fast: false
reversible: false

074417
type: SpeciesReference
stoichiometry: 1.0
species: 985656

074489
type: LocalParameter
value: 500.0

074477
type: LocalParameter
value: 0.0

074465
type: LocalParameter
value: 1000.0

074453
type: LocalParameter
value: 0.0

074381
type: SpeciesReference
stoichiometry: 1.0
species: 985848

074405
type: SpeciesReference
stoichiometry: 1.0
species: 985644

074369
type: SpeciesReference
stoichiometry: 1.0
species: 985632

074429
type: SpeciesReference
stoichiometry: 1.0
species: 985800

074393
type: SpeciesReference
stoichiometry: 1.0
species: 986597

986597
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Sarcosine

062299
type: Reaction
notes: GENE_ASSOCIATION: NM_000531.3 GENE_LIST: NM_000531.3 SUBSYSTEM: Arginine Metabolism
reactant: 062311
reactant: 062323
product: 062359
kinetic law: 062371
reversible: true
product: 062335
name: ornithine carbamoyltransferase, mitochondrial
fast: false
product: 062347

062311
type: SpeciesReference
stoichiometry: 1.0
species: 985316

062323
type: SpeciesReference
stoichiometry: 1.0
species: 986343

062359
type: SpeciesReference
stoichiometry: 1.0
species: 986451

062419
type: LocalParameter
value: 0.0

062407
type: LocalParameter
value: 0.0

062395
type: LocalParameter
value: 1000.0

062383
type: LocalParameter
value: -1000.0

062335
type: SpeciesReference
stoichiometry: 1.0
species: 985364

062347
type: SpeciesReference
stoichiometry: 1.0
species: 985836

999366
type: Reaction
product: 999427
name: acetyl-CoA carboxylase
kinetic law: 999463
reactant: 999378
notes: GENE_ASSOCIATION: (NM_198834.1 or NM_198839.1 or NM_198836.1 or NM_198837.1 or NM_001093.2 or NM_198838.1) GENE_LIST: NM_001093.2 NM_198834.1 NM_198836.1 NM_198837.1 NM_198838.1 NM_198839.1 SUBSYSTEM: Fatty Acid Metabolism
reactant: 999391
product: 999415
reactant: 999403
product: 999439
fast: false
reversible: false
product: 999451

999427
type: SpeciesReference
stoichiometry: 1.0
species: 983066

999511
type: LocalParameter
value: 500.0

999499
type: LocalParameter
value: 0.0

999487
type: LocalParameter
value: 1000.0

999475
type: LocalParameter
value: 0.0

999378
type: SpeciesReference
stoichiometry: 1.0
species: 981496

999391
type: SpeciesReference
stoichiometry: 1.0
species: 981738

999415
type: SpeciesReference
stoichiometry: 1.0
species: 981557

999403
type: SpeciesReference
stoichiometry: 1.0
species: 983102

999439
type: SpeciesReference
stoichiometry: 1.0
species: 983419

999451
type: SpeciesReference
stoichiometry: 1.0
species: 984094

981545
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Adenosine

076712
type: Reaction
product: 076772
kinetic law: 076784
reactant: 076748
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: false
product: 076760
reactant: 076736
name: delta24-sterol reductase
reactant: 076724

076772
type: SpeciesReference
stoichiometry: 1.0
species: 987243

076833
type: LocalParameter
value: 500.0

076821
type: LocalParameter
value: 0.0

076809
type: LocalParameter
value: 1000.0

076796
type: LocalParameter
value: 0.0

076748
type: SpeciesReference
stoichiometry: 1.0
species: 987230

076760
type: SpeciesReference
stoichiometry: 1.0
species: 987093

076736
type: SpeciesReference
stoichiometry: 1.0
species: 987105

076724
type: SpeciesReference
stoichiometry: 1.0
species: 987021

984516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Stearoylcarnitine (C18:0Crn)

012233
type: Reaction
kinetic law: 012270
product: 012258
reactant: 012246
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Cholesterol transport, blood

012318
type: LocalParameter
value: 0.0

012306
type: LocalParameter
value: 0.0

012294
type: LocalParameter
value: 1000.0

012282
type: LocalParameter
value: -1000.0

012258
type: SpeciesReference
stoichiometry: 1.0
species: 981907

012246
type: SpeciesReference
stoichiometry: 1.0
species: 980119

981411
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 3,4-Dihydroxy-L-phenylalanine

080266
type: Reaction
product: 080338
name: tyrosine 3-monooxygenase
fast: false
notes: GENE_ASSOCIATION: (NM_199293.2 or NM_199292.2 or NM_000360.3) GENE_LIST: NM_000360.3 NM_199292.2 NM_199293.2 SUBSYSTEM: Tyrosine metabolism
reactant: 080290
reactant: 080302
kinetic law: 080350
product: 080326
reactant: 080278
product: 080314
reversible: false

080338
type: SpeciesReference
stoichiometry: 1.0
species: 983078

080290
type: SpeciesReference
stoichiometry: 1.0
species: 984564

080302
type: SpeciesReference
stoichiometry: 1.0
species: 984696

080398
type: LocalParameter
value: 500.0

080386
type: LocalParameter
value: 0.0

080374
type: LocalParameter
value: 1000.0

080362
type: LocalParameter
value: 0.0

080326
type: SpeciesReference
stoichiometry: 1.0
species: 982306

080278
type: SpeciesReference
stoichiometry: 1.0
species: 983709

080314
type: SpeciesReference
stoichiometry: 1.0
species: 981411

047138
type: Reaction
kinetic law: 047174
product: 047162
reactant: 047150
notes: GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: H2O transport, mitochondrial

047222
type: LocalParameter
value: 0.0

047210
type: LocalParameter
value: 0.0

047198
type: LocalParameter
value: 1000.0

047186
type: LocalParameter
value: -1000.0

047162
type: SpeciesReference
stoichiometry: 1.0
species: 985848

047150
type: SpeciesReference
stoichiometry: 1.0
species: 983078

002614
type: Reaction
name: agmatinase (m)
reversible: false
reactant: 002638
fast: false
product: 002662
notes: GENE_ASSOCIATION: NM_024758.3 GENE_LIST: NM_024758.3 SUBSYSTEM: Arginine and Proline Metabolism
product: 002650
kinetic law: 002674
reactant: 002626

002638
type: SpeciesReference
stoichiometry: 1.0
species: 985848

002662
type: SpeciesReference
stoichiometry: 1.0
species: 986753

002650
type: SpeciesReference
stoichiometry: 1.0
species: 986560

002722
type: LocalParameter
value: 500.0

002710
type: LocalParameter
value: 0.0

002698
type: LocalParameter
value: 1000.0

002686
type: LocalParameter
value: 0.0

002626
type: SpeciesReference
stoichiometry: 1.0
species: 985207

001720
type: Reaction
kinetic law: 001769
product: 001757
product: 001745
reactant: 001733
notes: GENE_ASSOCIATION: (NM_139247.2 or NM_020546.1 or NM_015270.2 or NM_004036.2 or NM_183357.1 or NM_001116.2 or NM_001114.2 or NM_020983.2 or NM_021116.1 or NM_001115.1 or NM_018417.2) GENE_LIST: NM_001114.2 NM_001115.1 NM_001116.2 NM_004036.2 NM_015270.2 NM_018417.2 NM_020546.1 NM_020983.2 NM_021116.1 NM_139247.2 NM_183357.1 SUBSYSTEM: Nucleotides
fast: false
reversible: false
name: adenylate cyclase

001818
type: LocalParameter
value: 500.0

001806
type: LocalParameter
value: 0.0

001794
type: LocalParameter
value: 1000.0

001782
type: LocalParameter
value: 0.0

001757
type: SpeciesReference
stoichiometry: 1.0
species: 984202

001745
type: SpeciesReference
stoichiometry: 1.0
species: 981750

001733
type: SpeciesReference
stoichiometry: 1.0
species: 981738

062819
type: Reaction
reactant: 062843
kinetic law: 062879
product: 062867
notes: GENE_ASSOCIATION: (NM_022120.1 or NM_000436.2) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Leucine degradation
reversible: true
fast: false
name: 3-oxoacid CoA-transferase
reactant: 062831
product: 062855

062843
type: SpeciesReference
stoichiometry: 1.0
species: 986669

062927
type: LocalParameter
value: 0.0

062915
type: LocalParameter
value: 0.0

062903
type: LocalParameter
value: 1000.0

062891
type: LocalParameter
value: -1000.0

062867
type: SpeciesReference
stoichiometry: 1.0
species: 986657

062831
type: SpeciesReference
stoichiometry: 1.0
species: 985156

062855
type: SpeciesReference
stoichiometry: 1.0
species: 985120

999655
type: Reaction
name: aminocarboxymuconate-semialdehyde decarboxylase
fast: false
reactant: 999667
notes: GENE_ASSOCIATION: NM_138326.1 GENE_LIST: NM_138326.1 SUBSYSTEM: Tryptophan metabolism
kinetic law: 999715
reversible: false
product: 999691
reactant: 999679
product: 999703

999667
type: SpeciesReference
stoichiometry: 1.0
species: 981509

999764
type: LocalParameter
value: 500.0

999752
type: LocalParameter
value: 0.0

999739
type: LocalParameter
value: 1000.0

999727
type: LocalParameter
value: 0.0

999691
type: SpeciesReference
stoichiometry: 1.0
species: 981678

981678
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 2-Aminomuconate semialdehyde

999679
type: SpeciesReference
stoichiometry: 1.0
species: 983066

999703
type: SpeciesReference
stoichiometry: 1.0
species: 981979

017651
type: Reaction
reversible: true
reactant: 017675
name: carnitine octadecatrienoyltransferase (C18:3Crn, n3), mitochondrial
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 017663
product: 017687
kinetic law: 017713
product: 017700
fast: false

017675
type: SpeciesReference
stoichiometry: 1.0
species: 986294

017663
type: SpeciesReference
stoichiometry: 1.0
species: 985450

017687
type: SpeciesReference
stoichiometry: 1.0
species: 985413

017761
type: LocalParameter
value: 0.0

017749
type: LocalParameter
value: 0.0

017737
type: LocalParameter
value: 1000.0

017725
type: LocalParameter
value: -1000.0

017700
type: SpeciesReference
stoichiometry: 1.0
species: 986306

986306
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: octadecatrienoyl carnitine (C18:3Crn, n3)

022205
type: Reaction
kinetic law: 022266
fast: false
product: 022254
name: cytidylate kinase (CMP)(GTP)
product: 022242
reactant: 022218
reactant: 022230
reversible: true
notes: SUBSYSTEM: Pyrimidine Metabolism

022314
type: LocalParameter
value: 0.0

022302
type: LocalParameter
value: 0.0

022290
type: LocalParameter
value: 1000.0

022278
type: LocalParameter
value: -1000.0

022254
type: SpeciesReference
stoichiometry: 1.0
species: 982873

022242
type: SpeciesReference
stoichiometry: 1.0
species: 981786

022218
type: SpeciesReference
stoichiometry: 1.0
species: 981967

022230
type: SpeciesReference
stoichiometry: 1.0
species: 983054

056876
type: Reaction
kinetic law: 056913
product: 056901
reactant: 056889
notes: GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Phospholipid Metabolism
fast: false
reversible: false
name: myo-Inositol-1-phosphate synthase

056962
type: LocalParameter
value: 500.0

056950
type: LocalParameter
value: 0.0

056938
type: LocalParameter
value: 1000.0

056925
type: LocalParameter
value: 0.0

056901
type: SpeciesReference
stoichiometry: 1.0
species: 983517

983517
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 1D-myo-Inositol 1-phosphate

056889
type: SpeciesReference
stoichiometry: 1.0
species: 982849

987859
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: gly_b

037363
type: Reaction
name: Fructose-2,6-bisphosphate 2-phosphatase
reactant: 037387
fast: false
reactant: 037375
notes: GENE_ASSOCIATION: (NM_004567.2 or NM_006212.2 or NM_004566.2 or NM_003837.2 or NM_000507.2 or NM_002625.1 or NM_001018053.1) GENE_LIST: NM_000507.2 NM_001018053.1 NM_002625.1 NM_003837.2 NM_004566.2 NM_004567.2 NM_006212.2 SUBSYSTEM: Fructose and Mannose Metabolism
product: 037411
kinetic law: 037423
reversible: false
product: 037399

037387
type: SpeciesReference
stoichiometry: 1.0
species: 983078

037375
type: SpeciesReference
stoichiometry: 1.0
species: 982644

982644
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: D-Fructose 2,6-bisphosphate

037411
type: SpeciesReference
stoichiometry: 1.0
species: 984094

037471
type: LocalParameter
value: 500.0

037459
type: LocalParameter
value: 0.0

037447
type: LocalParameter
value: 1000.0

037435
type: LocalParameter
value: 0.0

037399
type: SpeciesReference
stoichiometry: 1.0
species: 982656

071857
type: Reaction
kinetic law: 071894
product: 071882
reactant: 071870
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion

071942
type: LocalParameter
value: 0.0

071930
type: LocalParameter
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071918
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value: 1000.0

071906
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value: -1000.0

071882
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stoichiometry: 1.0
species: 984322

071870
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species: 980794

000862
type: Reaction
reactant: 000886
product: 000910
kinetic law: 000946
reactant: 000898
name: acetyl-CoA synthetase
product: 000922
reactant: 000874
product: 000934
reversible: false
fast: false
notes: GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Glycolysis/ Gluconeogeneis

000886
type: SpeciesReference
stoichiometry: 1.0
species: 985279

000910
type: SpeciesReference
stoichiometry: 1.0
species: 985169

000994
type: LocalParameter
value: 500.0

000982
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value: 0.0

000970
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value: 1000.0

000958
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000898
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stoichiometry: 1.0
species: 985413

000922
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species: 985231

000874
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species: 985144

000934
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species: 986512

980253
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: eicosenoate (C20:1, n-9)

010212
type: Reaction
kinetic law: 010260
product: 010248
product: 010236
reactant: 010224
notes: SUBSYSTEM: ROS Detoxification
fast: false
reversible: false
name: catalase

010308
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value: 500.0

010296
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value: 0.0

010284
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value: 1000.0

010272
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value: 0.0

010248
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stoichiometry: 1.0
species: 983709

010236
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species: 983078

010224
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species: 983090

071360
type: Reaction
reactant: 071372
name: phosphoribosylpyrophosphate synthetase
reactant: 071384
product: 071408
kinetic law: 071432
reversible: true
product: 071420
fast: false
notes: GENE_ASSOCIATION: (NM_002764.2 or NM_002765.3 or NM_175886.2 or NM_001039091.1) GENE_LIST: NM_001039091.1 NM_002764.2 NM_002765.3 NM_175886.2 SUBSYSTEM: Purine Metabolism
product: 071396

071372
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species: 981738

071384
type: SpeciesReference
stoichiometry: 1.0
species: 984358

071408
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stoichiometry: 1.0
species: 983066

071480
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value: 0.0

071468
type: LocalParameter
value: 0.0

071456
type: LocalParameter
value: 1000.0

071444
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value: -1000.0

071420
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stoichiometry: 1.0
species: 984274

071396
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species: 981666

057685
type: Reaction
product: 057733
reactant: 057721
reversible: false
product: 057745
fast: false
name: methylmalonate-semialdehyde dehydrogenase (acylating)
reactant: 057709
reactant: 057697
kinetic law: 057769
notes: GENE_ASSOCIATION: NM_005589.2 GENE_LIST: NM_005589.2 SUBSYSTEM: Valine degradation
product: 057757

057733
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stoichiometry: 1.0
species: 985400

057721
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species: 986150

057745
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species: 986162

057709
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species: 986114

057697
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species: 985413

057817
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value: 500.0

057805
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value: 0.0

057793
type: LocalParameter
value: 1000.0

057781
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value: 0.0

057757
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stoichiometry: 1.0
species: 986500

032120
type: Reaction
kinetic law: 032254
fast: false
product: 032230
reactant: 032182
reactant: 032145
product: 032194
reactant: 032170
product: 032218
name: Beta oxidation of odd chain fatty acid
reactant: 032132
product: 032206
reversible: false
notes: GENE_ASSOCIATION: ((NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_001127328.1... GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001127328.1... NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
product: 032242
reactant: 032158

032302
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value: 500.0

032290
type: LocalParameter
value: 0.0

032278
type: LocalParameter
value: 1000.0

032266
type: LocalParameter
value: 0.0

032230
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stoichiometry: 1.0
species: 986162

032182
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stoichiometry: 1.0
species: 986379

032145
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species: 985632

032194
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species: 985169

032170
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species: 986150

032218
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stoichiometry: 1.0
species: 985836

032132
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stoichiometry: 1.0
species: 985413

032206
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species: 985644

032242
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species: 986729

032158
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stoichiometry: 1.0
species: 985848

984636
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: triglyceride, hepatocyte

992992
type: Reaction
kinetic law: 993029
product: 993017
reactant: 993005
fast: false
reversible: true
name: Glycerol exchange

993078
type: LocalParameter
value: 500.0

993066
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value: 0.0

993054
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value: 1000.0

993041
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value: 0.0

993017
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stoichiometry: 1.0
species: 987871

993005
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species: 980423

026481
type: Reaction
kinetic law: 026529
product: 026517
product: 026505
reactant: 026493
notes: GENE_ASSOCIATION: (NM_001724.3 or NM_001029891.2 or NM_199186.1 or NM_002629.2 or NM_000290.2) GENE_LIST: NM_000290.2 NM_001029891.2 NM_001724.3 NM_002629.2 NM_199186.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: Diphosphoglyceromutase

026578
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value: 0.0

026566
type: LocalParameter
value: 0.0

026553
type: LocalParameter
value: 1000.0

026541
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value: -1000.0

026517
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stoichiometry: 1.0
species: 983066

026505
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stoichiometry: 1.0
species: 981015

026493
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stoichiometry: 1.0
species: 980966

983853
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: octadecatrienoyl carnitine (C18:3Crn, n3)

036772
type: Reaction
kinetic law: 036892
product: 036880
fast: false
product: 036832
reactant: 036784
reactant: 036796
product: 036856
reversible: false
name: fatty acid synthase (n-C18:0)
reactant: 036808
product: 036844
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 036820
product: 036868

036940
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value: 500.0

036928
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value: 0.0

036916
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036904
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036880
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stoichiometry: 1.0
species: 983745

036832
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stoichiometry: 1.0
species: 981979

036784
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species: 983066

036796
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species: 983126

036856
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species: 983078

036808
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species: 983419

036844
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species: 981991

036820
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species: 983685

036868
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species: 983673

052189
type: Reaction
reactant: 052238
reactant: 052201
product: 052262
reversible: false
product: 052274
reactant: 052213
reactant: 052225
kinetic law: 052286
fast: false
notes: GENE_ASSOCIATION: (NM_001024956.1 or NM_006918.3) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Metabolism
name: lathosterol oxidase (NAD), endoplasmic reticulum
product: 052250

052238
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stoichiometry: 1.0
species: 987117

052201
type: SpeciesReference
stoichiometry: 1.0
species: 987021

052262
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species: 987033

052274
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species: 987069

052213
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stoichiometry: 1.0
species: 987057

052225
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species: 987081

052334
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value: 500.0

052322
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value: 0.0

052310
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value: 1000.0

052298
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value: 0.0

052250
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stoichiometry: 1.0
species: 986851

080749
type: Reaction
kinetic law: 080798
product: 080786
product: 080774
reactant: 080761
notes: GENE_ASSOCIATION: NM_000375.1 GENE_LIST: NM_000375.1 SUBSYSTEM: Heme Biosynthesis
fast: false
reversible: false
name: uroporphyrinogen-III synthase

080846
type: LocalParameter
value: 500.0

080834
type: LocalParameter
value: 0.0

080822
type: LocalParameter
value: 1000.0

080810
type: LocalParameter
value: 0.0

080786
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stoichiometry: 1.0
species: 984745

080774
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stoichiometry: 1.0
species: 983078

080761
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species: 983210

078348
type: Reaction
reversible: true
reactant: 078360
kinetic law: 078408
reactant: 078372
fast: false
product: 078396
product: 078384
notes: GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
name: L-threonine/glycine reversible exchange, blood

078360
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stoichiometry: 1.0
species: 980843

078458
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value: 0.0

078446
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value: 0.0

078434
type: LocalParameter
value: 1000.0

078421
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value: -1000.0

078372
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stoichiometry: 1.0
species: 982897

078396
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stoichiometry: 1.0
species: 984588

078384
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species: 980387

078590
type: Reaction
kinetic law: 078650
product: 078626
name: transketolase
fast: false
reversible: true
product: 078638
notes: GENE_ASSOCIATION: (NM_032136.3 or NM_001064.1 or NM_012253.2) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 078602
reactant: 078614

078698
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value: 0.0

078686
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value: 0.0

078674
type: LocalParameter
value: 1000.0

078662
type: LocalParameter
value: -1000.0

078626
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stoichiometry: 1.0
species: 982836

078638
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stoichiometry: 1.0
species: 984382

078602
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stoichiometry: 1.0
species: 984358

078614
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species: 984830

031926
type: Reaction
product: 032011
reactant: 031950
kinetic law: 032059
product: 031999
reactant: 031963
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.... GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.... NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
reversible: false
product: 032047
product: 032023
fast: false
reactant: 031987
reactant: 031975
name: Beta oxidation of long chain fatty acid
reactant: 031938
product: 032035

032011
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species: 985486

985486
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: Dodecanoyl-CoA (n-C12:0CoA)

031950
type: SpeciesReference
stoichiometry: 1.0
species: 985632

032108
type: LocalParameter
value: 500.0

032096
type: LocalParameter
value: 0.0

032084
type: LocalParameter
value: 1000.0

032072
type: LocalParameter
value: 0.0

031999
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stoichiometry: 1.0
species: 985169

031963
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stoichiometry: 1.0
species: 985848

032047
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species: 986162

032023
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species: 985644

031987
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species: 986693

031975
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species: 986150

031938
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stoichiometry: 1.0
species: 985413

032035
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stoichiometry: 1.0
species: 985836

014870
type: Reaction
product: 014906
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
kinetic law: 014930
reactant: 014882
fast: false
reactant: 014894
product: 014918
reversible: true
name: docosapentaenoyl carnitine transport (C22:5Crn, n3)

014906
type: SpeciesReference
stoichiometry: 1.0
species: 982040

014978
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value: 0.0

014966
type: LocalParameter
value: 0.0

014954
type: LocalParameter
value: 1000.0

014942
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value: -1000.0

014882
type: SpeciesReference
stoichiometry: 1.0
species: 982403

014894
type: SpeciesReference
stoichiometry: 1.0
species: 985450

014918
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stoichiometry: 1.0
species: 985536

985536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: docosapentaenoyl carnitine (C22:5Crn, n-3)

990175
type: Reaction
kinetic law: 990212
product: 990200
reactant: 990187
fast: false
reversible: true
name: L-Asparagine exchange

990261
type: LocalParameter
value: 500.0

990249
type: LocalParameter
value: 0.0

990237
type: LocalParameter
value: 1000.0

990224
type: LocalParameter
value: 0.0

990200
type: SpeciesReference
stoichiometry: 1.0
species: 987521

987521
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: asn_L_b

990187
type: SpeciesReference
stoichiometry: 1.0
species: 980071

007938
type: Reaction
product: 007986
name: aspartate transaminase
reactant: 007950
reactant: 007962
product: 007974
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism
reversible: false
kinetic law: 007998
fast: false

007986
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stoichiometry: 1.0
species: 984491

007950
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stoichiometry: 1.0
species: 981207

007962
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species: 981617

007974
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stoichiometry: 1.0
species: 982909

008046
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value: 500.0

008034
type: LocalParameter
value: 0.0

008022
type: LocalParameter
value: 1000.0

008010
type: LocalParameter
value: 0.0

999003
type: Reaction
kinetic law: 999063
reactant: 999027
product: 999051
reactant: 999015
reversible: true
fast: false
notes: GENE_ASSOCIATION: (NM_003051.3 or NM_013356.1 or NM_004696.1 or NM_004731.3 or NM_004695.2 or NM_004694.2 or NM_001042423.1 or NM_001042422.1 or NM_004207.1) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular
name: acetoacetate transport via proton symport, blood
product: 999039

999111
type: LocalParameter
value: 0.0

999099
type: LocalParameter
value: 0.0

999087
type: LocalParameter
value: 1000.0

999075
type: LocalParameter
value: -1000.0

999027
type: SpeciesReference
stoichiometry: 1.0
species: 980435

999051
type: SpeciesReference
stoichiometry: 1.0
species: 983066

999015
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stoichiometry: 1.0
species: 980034

999039
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species: 981472

073704
type: Reaction
kinetic law: 073800
fast: false
product: 073776
reactant: 073728
product: 073788
reactant: 073740
product: 073752
product: 073764
reversible: true
reactant: 073716
notes: GENE_ASSOCIATION: (NM_005763.2 or NM_016002.2) GENE_LIST: NM_005763.2 NM_016002.2 SUBSYSTEM: Lysine Degradation
name: saccharopine dehydrogenase (NAD, L-glutamate-forming), mitochondrial

073849
type: LocalParameter
value: 0.0

073836
type: LocalParameter
value: 0.0

073824
type: LocalParameter
value: 1000.0

073812
type: LocalParameter
value: -1000.0

073776
type: SpeciesReference
stoichiometry: 1.0
species: 985836

073728
type: SpeciesReference
stoichiometry: 1.0
species: 985848

073788
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species: 986162

073740
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stoichiometry: 1.0
species: 986150

073752
type: SpeciesReference
stoichiometry: 1.0
species: 985243

985243
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-2-Aminoadipate 6-semialdehyde

073764
type: SpeciesReference
stoichiometry: 1.0
species: 985752

073716
type: SpeciesReference
stoichiometry: 1.0
species: 985108

985108
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: L-Saccharopine

025238
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: NM_000858.4 GENE_LIST: NM_000858.4 SUBSYSTEM: Purine Metabolism
fast: false
reactant: 025250
product: 025274
name: deoxyguanylate kinase (dGMP:ATP)
reactant: 025262
kinetic law: 025298
product: 025286

025250
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stoichiometry: 1.0
species: 981738

025274
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stoichiometry: 1.0
species: 981557

025262
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stoichiometry: 1.0
species: 982270

025346
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value: 0.0

025334
type: LocalParameter
value: 0.0

025322
type: LocalParameter
value: 1000.0

025310
type: LocalParameter
value: -1000.0

025286
type: SpeciesReference
stoichiometry: 1.0
species: 982258

982258
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dGDP

057830
type: Reaction
product: 057902
fast: false
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: (((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3) or ((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Leucine degradation
reactant: 057866
reactant: 057842
product: 057890
kinetic law: 057914
reversible: false
reactant: 057854
product: 057878

057902
type: SpeciesReference
stoichiometry: 1.0
species: 986162

057866
type: SpeciesReference
stoichiometry: 1.0
species: 986150

057842
type: SpeciesReference
stoichiometry: 1.0
species: 985084

057890
type: SpeciesReference
stoichiometry: 1.0
species: 986018

057962
type: LocalParameter
value: 500.0

057950
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value: 0.0

057938
type: LocalParameter
value: 1000.0

057926
type: LocalParameter
value: 0.0

057854
type: SpeciesReference
stoichiometry: 1.0
species: 985413

057878
type: SpeciesReference
stoichiometry: 1.0
species: 985400

042853
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_005628.1 or NM_018018.2) GENE_LIST: NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
reactant: 042877
product: 042901
reactant: 042865
reversible: true
kinetic law: 042913
name: L-glutamine reversible transport via sodium symport, blood
product: 042889

042877
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stoichiometry: 1.0
species: 980605

042901
type: SpeciesReference
stoichiometry: 1.0
species: 983637

042865
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stoichiometry: 1.0
species: 980387

042961
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value: 0.0

042949
type: LocalParameter
value: 0.0

042937
type: LocalParameter
value: 1000.0

042925
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value: -1000.0

042889
type: SpeciesReference
stoichiometry: 1.0
species: 982897

980693
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: octadecadienoate (C18:2, n-6)

067245
type: Reaction
notes: SUBSYSTEM: Transport, Peroxisomal
reactant: 067270
fast: false
kinetic law: 067306
product: 067282
product: 067294
reversible: true
name: phosphate peroxisomal transport via proton symport
reactant: 067258

067270
type: SpeciesReference
stoichiometry: 1.0
species: 984094

067355
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value: 0.0

067343
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value: 0.0

067330
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value: 1000.0

067318
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value: -1000.0

067282
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stoichiometry: 1.0
species: 987353

067294
type: SpeciesReference
stoichiometry: 1.0
species: 987425

067258
type: SpeciesReference
stoichiometry: 1.0
species: 983066

000621
type: Reaction
kinetic law: 000657
product: 000645
reactant: 000633
notes: GENE_ASSOCIATION: NM_001098.2 GENE_LIST: NM_001098.2 SUBSYSTEM: Citric Acid Cycle
fast: false
reversible: true
name: Aconitate hydratase

000705
type: LocalParameter
value: 0.0

000693
type: LocalParameter
value: 0.0

000681
type: LocalParameter
value: 1000.0

000669
type: LocalParameter
value: -1000.0

000645
type: SpeciesReference
stoichiometry: 1.0
species: 985994

000633
type: SpeciesReference
stoichiometry: 1.0
species: 985352

068020
type: Reaction
product: 068068
notes: GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Metabolism
kinetic law: 068080
reversible: true
fast: false
product: 068056
reactant: 068032
name: phosphomevalonate kinase, reversible, peroxisome
reactant: 068044

068068
type: SpeciesReference
stoichiometry: 1.0
species: 987281

068128
type: LocalParameter
value: 0.0

068116
type: LocalParameter
value: 0.0

068104
type: LocalParameter
value: 1000.0

068092
type: LocalParameter
value: -1000.0

068056
type: SpeciesReference
stoichiometry: 1.0
species: 987256

068032
type: SpeciesReference
stoichiometry: 1.0
species: 987269

068044
type: SpeciesReference
stoichiometry: 1.0
species: 987293

081787
type: Reaction
kinetic law: 081823
product: 081811
reactant: 081799
notes: GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-valine transport via diffusion, blood

081871
type: LocalParameter
value: 0.0

081859
type: LocalParameter
value: 0.0

081847
type: LocalParameter
value: 1000.0

081835
type: LocalParameter
value: -1000.0

081811
type: SpeciesReference
stoichiometry: 1.0
species: 984805

081799
type: SpeciesReference
stoichiometry: 1.0
species: 980917

980917
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Valine

994734
type: Reaction
kinetic law: 994770
product: 994758
reactant: 994746
fast: false
reversible: true
name: octadecanoate (n-C18:0) exchange

994818
type: LocalParameter
value: 500.0

994806
type: LocalParameter
value: 0.0

994794
type: LocalParameter
value: 1000.0

994782
type: LocalParameter
value: 0.0

994758
type: SpeciesReference
stoichiometry: 1.0
species: 988090

988090
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ocdca_b

994746
type: SpeciesReference
stoichiometry: 1.0
species: 980642

008058
type: Reaction
reversible: false
product: 008095
reactant: 008070
notes: GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Cysteine Metabolism
kinetic law: 008119
reactant: 008083
name: aspartate transaminase, mitochondrial
fast: false
product: 008107

008095
type: SpeciesReference
stoichiometry: 1.0
species: 985752

008070
type: SpeciesReference
stoichiometry: 1.0
species: 985059

985059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: 3-Sulfino-L-alanine

008167
type: LocalParameter
value: 500.0

008155
type: LocalParameter
value: 0.0

008143
type: LocalParameter
value: 1000.0

008131
type: LocalParameter
value: 0.0

008083
type: SpeciesReference
stoichiometry: 1.0
species: 985219

008107
type: SpeciesReference
stoichiometry: 1.0
species: 986621

998253
type: Reaction
reactant: 998289
notes: GENE_ASSOCIATION: NM_001182.2 GENE_LIST: NM_001182.2 SUBSYSTEM: Lysine Degradation
fast: false
reactant: 998277
kinetic law: 998337
product: 998313
name: L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
reversible: false
product: 998301
product: 998325
reactant: 998265

998289
type: SpeciesReference
stoichiometry: 1.0
species: 986150

998277
type: SpeciesReference
stoichiometry: 1.0
species: 985848

998386
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value: 500.0

998374
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998362
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value: 1000.0

998350
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998313
type: SpeciesReference
stoichiometry: 2.0
species: 985836

998301
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stoichiometry: 1.0
species: 984866

998325
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stoichiometry: 1.0
species: 986162

998265
type: SpeciesReference
stoichiometry: 1.0
species: 985243

001138
type: Reaction
reactant: 001162
reactant: 001150
reversible: true
kinetic law: 001198
product: 001174
notes: SUBSYSTEM: Transport, Mitochondrial
product: 001186
fast: false
name: acetate mitochondrial transport via proton symport

001162
type: SpeciesReference
stoichiometry: 1.0
species: 983066

001150
type: SpeciesReference
stoichiometry: 1.0
species: 981460

001247
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value: 0.0

001235
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value: 0.0

001222
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value: 1000.0

001210
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value: -1000.0

001174
type: SpeciesReference
stoichiometry: 1.0
species: 985144

001186
type: SpeciesReference
stoichiometry: 1.0
species: 985836

023512
type: Reaction
reactant: 023525
product: 023586
notes: GENE_ASSOCIATION: (NM_206918.1 or NM_144780.1 or NM_003676.2) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Sphingomyelin
kinetic law: 023610
product: 023598
reactant: 023562
reactant: 023538
reversible: false
fast: false
reactant: 023550
product: 023574
name: Dihydroceramide desaturase, myocyte

023525
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stoichiometry: 0.001
species: 982174

023586
type: SpeciesReference
stoichiometry: 2.0
species: 983078

023658
type: LocalParameter
value: 500.0

023646
type: LocalParameter
value: 0.0

023634
type: LocalParameter
value: 1000.0

023622
type: LocalParameter
value: 0.0

023598
type: SpeciesReference
stoichiometry: 1.0
species: 983673

023562
type: SpeciesReference
stoichiometry: 1.0
species: 983709

023538
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stoichiometry: 1.0
species: 983066

023550
type: SpeciesReference
stoichiometry: 1.0
species: 983685

023574
type: SpeciesReference
stoichiometry: 0.001
species: 981822

063952
type: Reaction
name: pyrroline-5-carboxylate reductase
reversible: false
fast: false
kinetic law: 064025
notes: GENE_ASSOCIATION: (NM_023078.1 or NM_013328.2) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
product: 064013
product: 064001
reactant: 063977
reactant: 063965
reactant: 063989

064073
type: LocalParameter
value: 500.0

064061
type: LocalParameter
value: 0.0

064049
type: LocalParameter
value: 1000.0

064037
type: LocalParameter
value: 0.0

064013
type: SpeciesReference
stoichiometry: 1.0
species: 984262

064001
type: SpeciesReference
stoichiometry: 1.0
species: 983649

063977
type: SpeciesReference
stoichiometry: 2.0
species: 983066

063965
type: SpeciesReference
stoichiometry: 1.0
species: 981002

063989
type: SpeciesReference
stoichiometry: 1.0
species: 983661

986827
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: 6-Phospho-D-gluconate

058263
type: Reaction
product: 058312
name: methenyltetrahydrofolate cyclohydrolase
kinetic law: 058324
product: 058300
notes: SUBSYSTEM: Folate Metabolism
reversible: true
reactant: 058288
reactant: 058275
fast: false

058312
type: SpeciesReference
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species: 983066

058372
type: LocalParameter
value: 0.0

058360
type: LocalParameter
value: 0.0

058348
type: LocalParameter
value: 1000.0

058336
type: LocalParameter
value: -1000.0

058300
type: SpeciesReference
stoichiometry: 1.0
species: 980929

058288
type: SpeciesReference
stoichiometry: 1.0
species: 983481

058275
type: SpeciesReference
stoichiometry: 1.0
species: 983078

039058
type: Reaction
notes: SUBSYSTEM: Transport, Mitochondrial
reversible: true
kinetic law: 039118
reactant: 039070
reactant: 039082
fast: false
name: fumarate malate antiport, mitochondrial
product: 039094
product: 039106

039166
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039154
type: LocalParameter
value: 0.0

039142
type: LocalParameter
value: 1000.0

039130
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039070
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stoichiometry: 1.0
species: 982812

039082
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species: 986066

039094
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species: 983407

039106
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stoichiometry: 1.0
species: 985716

980277
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: eicosatrienoate (C20:3, n-6)

046605
type: Reaction
reactant: 046629
product: 046666
name: GTP cyclohydrolase I
kinetic law: 046678
reactant: 046617
notes: GENE_ASSOCIATION: (NM_001024024.1 or NM_000161.2) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
reversible: false
product: 046654
fast: false
product: 046642

046629
type: SpeciesReference
stoichiometry: 1.0
species: 983078

046666
type: SpeciesReference
stoichiometry: 1.0
species: 983066

046727
type: LocalParameter
value: 500.0

046715
type: LocalParameter
value: 0.0

046702
type: LocalParameter
value: 1000.0

046690
type: LocalParameter
value: 0.0

046617
type: SpeciesReference
stoichiometry: 1.0
species: 983054

046654
type: SpeciesReference
stoichiometry: 1.0
species: 982740

046642
type: SpeciesReference
stoichiometry: 1.0
species: 981581

034906
type: Reaction
product: 035026
reactant: 034918
reactant: 034966
kinetic law: 035039
reversible: false
reactant: 034930
fast: false
name: Beta oxidation of fatty acid
reactant: 034954
product: 034990
product: 034978
reactant: 034942
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_000017.2 and (NM_000182.3 and NM_000183.1)) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092... GENE_LIST: NM_000016.2 NM_000017.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
product: 035014
product: 035002

035026
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species: 986162

034918
type: SpeciesReference
stoichiometry: 1.0
species: 985413

034966
type: SpeciesReference
stoichiometry: 1.0
species: 986150

035087
type: LocalParameter
value: 500.0

035075
type: LocalParameter
value: 0.0

035063
type: LocalParameter
value: 1000.0

035051
type: LocalParameter
value: 0.0

034930
type: SpeciesReference
stoichiometry: 1.0
species: 985632

034954
type: SpeciesReference
stoichiometry: 1.0
species: 985969

034990
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stoichiometry: 1.0
species: 985303

034978
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stoichiometry: 1.0
species: 985169

034942
type: SpeciesReference
stoichiometry: 1.0
species: 985848

035014
type: SpeciesReference
stoichiometry: 1.0
species: 985836

035002
type: SpeciesReference
stoichiometry: 1.0
species: 985644

060355
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dTDP)
reactant: 060379
product: 060391
product: 060403
kinetic law: 060415
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018138.1) or (NM_001018137.1 and NM_198175.1) or NM_013330.3 or NM_005793.3 or NM_197972.1 or NM_002513.2 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Pyrimidine Metabolism
reversible: true
reactant: 060367
fast: false

060379
type: SpeciesReference
stoichiometry: 1.0
species: 982415

982415
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: dTDP

060391
type: SpeciesReference
stoichiometry: 1.0
species: 981557

060403
type: SpeciesReference
stoichiometry: 1.0
species: 982439

060463
type: LocalParameter
value: 0.0

060451
type: LocalParameter
value: 0.0

060439
type: LocalParameter
value: 1000.0

060427
type: LocalParameter
value: -1000.0

060367
type: SpeciesReference
stoichiometry: 1.0
species: 981738

994154
type: Reaction
kinetic law: 994190
product: 994178
reactant: 994166
fast: false
reversible: true
name: L-Lysine exchange

994238
type: LocalParameter
value: -0.00408

994226
type: LocalParameter
value: 0.0

994214
type: LocalParameter
value: 0.0

994202
type: LocalParameter
value: -0.00816

994178
type: SpeciesReference
stoichiometry: 1.0
species: 988017

994166
type: SpeciesReference
stoichiometry: 1.0
species: 980569

075866
type: Reaction
kinetic law: 075939
reversible: true
product: 075915
reactant: 075891
name: sepiapterin reductase, reversible
product: 075927
reactant: 075903
reactant: 075879
notes: GENE_ASSOCIATION: NM_003124.3 GENE_LIST: NM_003124.3 SUBSYSTEM: Tetrahydrobiopterin
fast: false

075987
type: LocalParameter
value: 0.0

075975
type: LocalParameter
value: 0.0

075963
type: LocalParameter
value: 1000.0

075951
type: LocalParameter
value: -1000.0

075915
type: SpeciesReference
stoichiometry: 2.0
species: 983673

075891
type: SpeciesReference
stoichiometry: 2.0
species: 983066

075927
type: SpeciesReference
stoichiometry: 1.0
species: 984564

075903
type: SpeciesReference
stoichiometry: 2.0
species: 983685

075879
type: SpeciesReference
stoichiometry: 1.0
species: 981399

071010
type: Reaction
reversible: false
product: 071058
reactant: 071022
name: Proline dehydrogenase (m)
notes: GENE_ASSOCIATION: (NM_016335.3 or NM_021232.1) GENE_LIST: NM_016335.3 NM_021232.1 SUBSYSTEM: Proline Metabolism
kinetic law: 071082
fast: false
product: 071070
product: 071046
reactant: 071034

071058
type: SpeciesReference
stoichiometry: 1.0
species: 985644

071022
type: SpeciesReference
stoichiometry: 1.0
species: 985632

071130
type: LocalParameter
value: 500.0

071118
type: LocalParameter
value: 0.0

071106
type: LocalParameter
value: 1000.0

071094
type: LocalParameter
value: 0.0

071070
type: SpeciesReference
stoichiometry: 1.0
species: 985836

071046
type: SpeciesReference
stoichiometry: 1.0
species: 984854

071034
type: SpeciesReference
stoichiometry: 1.0
species: 986536

016199
type: Reaction
reactant: 016223
product: 016247
name: carnitine hexadecenoyltransferase (C16:1Crn, n7), mitochondrial
reversible: true
reactant: 016211
kinetic law: 016259
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
fast: false
product: 016235

016223
type: SpeciesReference
stoichiometry: 1.0
species: 985885

016247
type: SpeciesReference
stoichiometry: 1.0
species: 985897

016211
type: SpeciesReference
stoichiometry: 1.0
species: 985450

016308
type: LocalParameter
value: 0.0

016295
type: LocalParameter
value: 0.0

016283
type: LocalParameter
value: 1000.0

016271
type: LocalParameter
value: -1000.0

016235
type: SpeciesReference
stoichiometry: 1.0
species: 985413

023804
type: Reaction
kinetic law: 023840
product: 023828
reactant: 023816
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: docosahexaenoate (C22:6, n-3) transport

023888
type: LocalParameter
value: 0.0

023876
type: LocalParameter
value: 0.0

023864
type: LocalParameter
value: 1000.0

023852
type: LocalParameter
value: -1000.0

023828
type: SpeciesReference
stoichiometry: 1.0
species: 982198

023816
type: SpeciesReference
stoichiometry: 1.0
species: 980192

073607
type: Reaction
kinetic law: 073643
product: 073631
reactant: 073619
notes: SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribose-5-phosphate isomerase, endoplasmic reticulum

073692
type: LocalParameter
value: 0.0

073680
type: LocalParameter
value: 0.0

073667
type: LocalParameter
value: 1000.0

073655
type: LocalParameter
value: -1000.0

073631
type: SpeciesReference
stoichiometry: 1.0
species: 987165

073619
type: SpeciesReference
stoichiometry: 1.0
species: 987153

987153
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979948
name: alpha-D-Ribose 5-phosphate

063326
type: Reaction
reactant: 063351
name: ornithine transaminase, mitochondrial
kinetic law: 063387
reversible: true
product: 063375
fast: false
reactant: 063338
notes: GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine Metabolism
product: 063363

063351
type: SpeciesReference
stoichiometry: 1.0
species: 986343

063435
type: LocalParameter
value: 0.0

063423
type: LocalParameter
value: 0.0

063411
type: LocalParameter
value: 1000.0

063399
type: LocalParameter
value: -1000.0

063375
type: SpeciesReference
stoichiometry: 1.0
species: 985776

063338
type: SpeciesReference
stoichiometry: 1.0
species: 985219

063363
type: SpeciesReference
stoichiometry: 1.0
species: 985752

985376
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: cardiolipin, myocyte

037957
type: Reaction
reactant: 037982
fast: false
product: 038031
name: formyltetrahydrofolate dehydrogenase
reactant: 037970
kinetic law: 038055
notes: GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Folate Metabolism
product: 038006
reversible: false
product: 038043
product: 038018
reactant: 037994

037982
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species: 983078

038031
type: SpeciesReference
stoichiometry: 1.0
species: 983685

037970
type: SpeciesReference
stoichiometry: 1.0
species: 980929

038103
type: LocalParameter
value: 500.0

038091
type: LocalParameter
value: 0.0

038079
type: LocalParameter
value: 1000.0

038067
type: LocalParameter
value: 0.0

038006
type: SpeciesReference
stoichiometry: 1.0
species: 981979

038043
type: SpeciesReference
stoichiometry: 1.0
species: 984576

038018
type: SpeciesReference
stoichiometry: 1.0
species: 983066

037994
type: SpeciesReference
stoichiometry: 1.0
species: 983673

080531
type: Reaction
kinetic law: 080567
product: 080555
reactant: 080543
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_182728.1 or NM_012244.2 or NM_018593.3) GENE_LIST: NM_003486.5 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tyrosine transport

080615
type: LocalParameter
value: 0.0

080603
type: LocalParameter
value: 0.0

080591
type: LocalParameter
value: 1000.0

080579
type: LocalParameter
value: -1000.0

080555
type: SpeciesReference
stoichiometry: 1.0
species: 984696

080543
type: SpeciesReference
stoichiometry: 1.0
species: 980892

060956
type: Reaction
kinetic law: 060992
product: 060980
reactant: 060968
notes: GENE_ASSOCIATION: (NM_020407.1 or NM_000324.1 or NM_016321.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ammonium transport via diffusion

061040
type: LocalParameter
value: 0.0

061028
type: LocalParameter
value: 0.0

061016
type: LocalParameter
value: 1000.0

061004
type: LocalParameter
value: -1000.0

060980
type: SpeciesReference
stoichiometry: 1.0
species: 983697

060968
type: SpeciesReference
stoichiometry: 1.0
species: 980617

053019
type: Reaction
kinetic law: 053055
product: 053043
reactant: 053031
notes: GENE_ASSOCIATION: (NM_003627.4 or NM_003486.5 or NM_012244.2 or NM_003982.3 or NM_001126106.1 or NM_001126105.1 or NM_182728.1) GENE_LIST: NM_001126105.1 NM_001126106.1 NM_003486.5 NM_003627.4 NM_003982.3 NM_012244.2 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-leucine transport via diffusion, blood

053103
type: LocalParameter
value: 0.0

053091
type: LocalParameter
value: 0.0

053079
type: LocalParameter
value: 1000.0

053067
type: LocalParameter
value: -1000.0

053043
type: SpeciesReference
stoichiometry: 1.0
species: 983371

053031
type: SpeciesReference
stoichiometry: 1.0
species: 980556

010320
type: Reaction
kinetic law: 010369
product: 010356
product: 010344
reactant: 010332
notes: SUBSYSTEM: ROS Detoxification
fast: false
reversible: false
name: catalase, mitochondrial

010417
type: LocalParameter
value: 500.0

010405
type: LocalParameter
value: 0.0

010393
type: LocalParameter
value: 1000.0

010381
type: LocalParameter
value: 0.0

010356
type: SpeciesReference
stoichiometry: 1.0
species: 986222

010344
type: SpeciesReference
stoichiometry: 2.0
species: 985848

010332
type: SpeciesReference
stoichiometry: 2.0
species: 985861

057360
type: Reaction
reactant: 057384
reactant: 057396
product: 057408
notes: SUBSYSTEM: Valine degradation
kinetic law: 057432
fast: false
reactant: 057372
product: 057420
name: (S)-methylmalonyl-CoA hydrolase
reversible: false

057384
type: SpeciesReference
stoichiometry: 1.0
species: 985836

057396
type: SpeciesReference
stoichiometry: 1.0
species: 986102

057408
type: SpeciesReference
stoichiometry: 1.0
species: 985848

057480
type: LocalParameter
value: 500.0

057468
type: LocalParameter
value: 0.0

057456
type: LocalParameter
value: 1000.0

057444
type: LocalParameter
value: 0.0

057372
type: SpeciesReference
stoichiometry: 1.0
species: 985413

057420
type: SpeciesReference
stoichiometry: 1.0
species: 986138

983962
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: Phosphatidylcholine, human hepatocyte

988102
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ocdcea9_b

051027
type: Reaction
kinetic law: 051063
product: 051052
reactant: 051039
notes: GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-isoleucine transport via diffusion, blood

051112
type: LocalParameter
value: 0.0

051100
type: LocalParameter
value: 0.0

051088
type: LocalParameter
value: 1000.0

051075
type: LocalParameter
value: -1000.0

051052
type: SpeciesReference
stoichiometry: 1.0
species: 983284

051039
type: SpeciesReference
stoichiometry: 1.0
species: 980520

980520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979972
name: L-Isoleucine

980942
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979924
name: 1,2-Diacylglycerol, human hepatocyte

033804
type: Reaction
reversible: false
reactant: 033852
reactant: 033840
kinetic law: 033925
product: 033877
fast: false
product: 033913
reactant: 033865
name: Beta oxidation of fatty acid
reactant: 033816
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001037811.2... NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty Acid Degradation
product: 033901
reactant: 033828
product: 033889

033852
type: SpeciesReference
stoichiometry: 9.0
species: 985848

033840
type: SpeciesReference
stoichiometry: 5.0
species: 985632

033974
type: LocalParameter
value: 500.0

033961
type: LocalParameter
value: 0.0

033949
type: LocalParameter
value: 1000.0

033937
type: LocalParameter
value: 0.0

033877
type: SpeciesReference
stoichiometry: 10.0
species: 985169

033913
type: SpeciesReference
stoichiometry: 9.0
species: 986162

033865
type: SpeciesReference
stoichiometry: 9.0
species: 986150

033816
type: SpeciesReference
stoichiometry: 9.0
species: 985413

033901
type: SpeciesReference
stoichiometry: 9.0
species: 985836

033828
type: SpeciesReference
stoichiometry: 1.0
species: 985608

985608
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)

033889
type: SpeciesReference
stoichiometry: 5.0
species: 985644

010889
type: Reaction
reversible: true
kinetic law: 010961
product: 010925
reactant: 010913
product: 010937
notes: GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Metabolism
name: CDP-diacylglycerol--serine O-phosphatidyltransferase, mitochondrial, human myocyte
reactant: 010901
fast: false
product: 010949

011010
type: LocalParameter
value: 0.0

010998
type: LocalParameter
value: 0.0

010986
type: LocalParameter
value: 1000.0

010973
type: LocalParameter
value: -1000.0

010925
type: SpeciesReference
stoichiometry: 1.0
species: 985388

985388
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979936
name: CMP

010913
type: SpeciesReference
stoichiometry: 1.0
species: 985812

010937
type: SpeciesReference
stoichiometry: 1.0
species: 985836

010901
type: SpeciesReference
stoichiometry: 0.001
species: 985340

010949
type: SpeciesReference
stoichiometry: 0.001
species: 986427

048927
type: Reaction
product: 048963
reversible: false
product: 048987
fast: false
notes: GENE_ASSOCIATION: (NM_014362.2 or NM_198047.1) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine degradation
reactant: 048951
kinetic law: 048999
product: 048975
reactant: 048939
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

048963
type: SpeciesReference
stoichiometry: 1.0
species: 984998

048987
type: SpeciesReference
stoichiometry: 1.0
species: 985836

048951
type: SpeciesReference
stoichiometry: 1.0
species: 985909

049047
type: LocalParameter
value: 500.0

049035
type: LocalParameter
value: 0.0

049023
type: LocalParameter
value: 1000.0

049011
type: LocalParameter
value: 0.0

048975
type: SpeciesReference
stoichiometry: 1.0
species: 985413

048939
type: SpeciesReference
stoichiometry: 1.0
species: 985848

035861
type: Reaction
product: 035958
name: fatty acid synthase (n-C12:0)
reversible: false
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
product: 035922
kinetic law: 035982
product: 035946
reactant: 035873
reactant: 035897
fast: false
product: 035934
reactant: 035910
reactant: 035885
product: 035970

035958
type: SpeciesReference
stoichiometry: 1.0
species: 983078

035922
type: SpeciesReference
stoichiometry: 1.0
species: 981979

036031
type: LocalParameter
value: 500.0

036019
type: LocalParameter
value: 0.0

036006
type: LocalParameter
value: 1000.0

035994
type: LocalParameter
value: 0.0

035946
type: SpeciesReference
stoichiometry: 1.0
species: 982246

035873
type: SpeciesReference
stoichiometry: 1.0
species: 982137

035897
type: SpeciesReference
stoichiometry: 1.0
species: 983419

035934
type: SpeciesReference
stoichiometry: 1.0
species: 981991

035910
type: SpeciesReference
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species: 983685

035885
type: SpeciesReference
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species: 983066

035970
type: SpeciesReference
stoichiometry: 2.0
species: 983673

065647
type: Reaction
kinetic law: 065720
reversible: false
notes: SUBSYSTEM: Pentose Phosphate Pathway
product: 065708
product: 065696
reactant: 065672
fast: false
product: 065684
name: phosphogluconate dehydrogenase, endoplasmic reticulum
reactant: 065659

065768
type: LocalParameter
value: 500.0

065756
type: LocalParameter
value: 0.0

065744
type: LocalParameter
value: 1000.0

065732
type: LocalParameter
value: 0.0

065708
type: SpeciesReference
stoichiometry: 1.0
species: 987165

065696
type: SpeciesReference
stoichiometry: 1.0
species: 987105

065672
type: SpeciesReference
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species: 987093

065684
type: SpeciesReference
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species: 986899

065659
type: SpeciesReference
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species: 986827

991727
type: Reaction
kinetic law: 991763
product: 991751
reactant: 991739
fast: false
reversible: true
name: eicosapentaenoate (C20:5, n-3) exchange

991811
type: LocalParameter
value: 500.0

991799
type: LocalParameter
value: 0.0

991787
type: LocalParameter
value: 1000.0

991775
type: LocalParameter
value: 0.0

991751
type: SpeciesReference
stoichiometry: 1.0
species: 987713

987713
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 979985
name: ecspea3_b

991739
type: SpeciesReference
stoichiometry: 1.0
species: 980265

031523
type: Reaction
fast: false
product: 031643
reactant: 031583
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: ((NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2)) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty Acid Degradation
reactant: 031535
product: 031619
product: 031631
reactant: 031571
kinetic law: 031656
reactant: 031547
reactant: 031559
product: 031595
product: 031607
reversible: false

031643
type: SpeciesReference
stoichiometry: 1.0
species: 986162

031583
type: SpeciesReference
stoichiometry: 1.0
species: 986150

031535
type: SpeciesReference
stoichiometry: 1.0
species: 985413

031619
type: SpeciesReference
stoichiometry: 1.0
species: 985644

031631
type: SpeciesReference
stoichiometry: 1.0
species: 985836

031571
type: SpeciesReference
stoichiometry: 1.0
species: 985848

031709
type: LocalParameter
value: 500.0