GENE_ASSOCIATION: (NM_024664.2 or NM_001077447.1) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
GENE_ASSOCIATION: NM_012205.1 GENE_LIST: NM_012205.1 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
carnitine palmitoyltransferase (C16:0Crn), mitochondrial
L-methionine transport in via sodium symport, blood
fatty-acid--CoA ligase (docosapentaenoate, C22:5 n-3)
Nicotinamide adenine dinucleotide - reduced
monoacylglycerol hydrolase, human myocyte
GENE_ASSOCIATION: (NM_007283.5 or NM_001003794.1) GENE_LIST: NM_001003794.1 NM_007283.5 SUBSYSTEM: Phospholipid Metabolism
dimethylallyl diphosphate transport, peroxisome
alphaketobutyrate dehydrogenase (mitochondrial)
carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
acetyl-CoA C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Isoleucine degradation
3',5'-cyclic-nucleotide phosphodiesterase
GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Nucleotide Cycle
(S)-Methylmalonate semialdehyde transport, mitochondrial
GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
hexadecenoyl carnitine transprot (C16:1Crn, n7)
GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Metabolism
CDP-Diacylglycerol synthetase, human myocyte
docosapentaenoyl carnitine (C22:5Crn, n-3)
GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_000188.1 or NM_000189.4 or NM_002115.1 or NM_033497.1) GENE_LIST: NM_000188.1 NM_000189.4 NM_002115.1 NM_033497.1 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine Metabolism
fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
GENE_ASSOCIATION: (NM_175859.1 or NM_019857.3) GENE_LIST: NM_019857.3 NM_175859.1 SUBSYSTEM: Pyrimidine Metabolism
Octadecatrienoate (C18:3, n-3) transport
GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: (NM_000159.2 or NM_013976.2) GENE_LIST: NM_000159.2 NM_013976.2 SUBSYSTEM: Lysine Degradation
glutaryl-CoA dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_004077.2 or NM_198324.1) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citric Acid Cycle
eicosapentaenoyl carnitine (C20:5Crn, n-3)
GENE_ASSOCIATION: (NM_152328.3 or NM_199165.1 or NM_001126.2) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Purine Nucleotide Cycle
GENE_ASSOCIATION: (NM_014905.2 or NM_013267.2) GENE_LIST: NM_013267.2 NM_014905.2 SUBSYSTEM: Glutamate metabolism
Nicotinamide adenine dinucleotide phosphate - reduced
Nicotinamide adenine dinucleotide phosphate
SUBSYSTEM: Glycine and Serine Metabolism
SUBSYSTEM: Transport, Endoplasmic Reticular
acetoacetate transport via proton symport, mitochondrial
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine degradation
3-hydroxyisobutyrate dehydrogenase, mitochondrial
Eicosapentaenoate (C20:5, n-3) transport
GENE_ASSOCIATION: (NM_001099646.1 or NM_152908.2 or NM_018242.2) GENE_LIST: NM_001099646.1 NM_018242.2 NM_152908.2 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_005628.1 GENE_LIST: NM_005628.1 SUBSYSTEM: Transport, Extracellular
nucleoside-diphosphate kinase (ATP:dUDP)
phosphatidylglycerol phosphate phosphatase A, mitochondrial, human myocyte
Phosphatidylglycerophosphate, human myocyte
cytochrome P450 lanosterol 14-alpha-demethylase
GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism
carnitine O-palmitoyltransferase (C16:0Crn)
acetate transport in/out via proton symport
Biomass Demand, Human Myocyte (biosynthetic GAM)
phosphatidyl-1D-myo-inositol, human myocyte
tetradecanoyl carnitine transport (C14:0Crn)
phosphatidate reversible transport, mitochondrial, myocyte
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Tetrahydrobiopterin
GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_003849.1 and NM_003850.1) GENE_LIST: NM_003849.1 NM_003850.1 SUBSYSTEM: Citric Acid Cycle
fatty-acyl-CoA elongation (C20:4CoA, n3)
2-oxoglutarate dehydrogenase, mitochondrial
L-alanine/glutamine reversible exchange, blood
Phosphocreatine transport to/from mitochondria via diffusion
GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides
eicosatetraenoyl carnitine (C20:4Crn, n-6)
carnitine eicosatetraenoyltransferase (C20:4Crn, n6)
GENE_ASSOCIATION: (NM_002115.1 or NM_033497.1 or NM_000189.4 or NM_000188.1) GENE_LIST: NM_000188.1 NM_000189.4 NM_002115.1 NM_033497.1 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Anaplerotic reactions
fatty-acid--CoA ligase (heptadecanoate, C17:0)
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Phenylalanine metabolism
GENE_ASSOCIATION: (NM_000617.1 or NM_000578.2 or NM_014585.3) GENE_LIST: NM_000578.2 NM_000617.1 NM_014585.3 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_052998.2 GENE_LIST: NM_052998.2 SUBSYSTEM: Arginine and Proline Metabolism
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_005628.1 or NM_003038.2) GENE_LIST: NM_003038.2 NM_005628.1 SUBSYSTEM: Transport, Extracellular
Ceramide cholinephosphotransferase, human myocyte
GENE_ASSOCIATION: (NM_016612.2 or NM_031212.2) GENE_LIST: NM_016612.2 NM_031212.2 SUBSYSTEM: Transport, Mitochondrial
cholesterol efflux (ATP depedent), blood
aspartate carbamoyltransferase (reversible)
GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Metabolism
Tetradecanoate (n-C14:0) transport in via uniport
GENE_ASSOCIATION: (NM_003060.2 or NM_003059.2) GENE_LIST: NM_003059.2 NM_003060.2 SUBSYSTEM: Transport, Extracellular
L-carnitine inward transport by Na+ symport
L-asparagine transport in via sodium symport, blood
GENE_ASSOCIATION: NM_018677.2 GENE_LIST: NM_018677.2 SUBSYSTEM: Propanoate Metabolism
docosahexaenoyl carnitine (C22:6Crn, n-3)
GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Transport, Mitochondrial
docosahexaenoyl carnitine transport (C22:6Crn, n3)
GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Anaplerotic reactions
methylmalonyl-CoA epimerase, mitochondrial
4-aminobutyrate transaminase, reversible (mitochondrial)
GENE_ASSOCIATION: (NM_020686.3 or NM_000663.2) GENE_LIST: NM_000663.2 NM_020686.3 SUBSYSTEM: Glutamate Metabolism
GENE_ASSOCIATION: (NM_001098486.1 or NM_006632.3 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Peroxisomal
phosphate transporter, endoplasmic reticulum
GENE_ASSOCIATION: (NM_206965.1 or NM_006657.2) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
carnitine octadecanoyltransferase (C18:0Crn), mitochondria
GENE_ASSOCIATION: NM_144639.1 GENE_LIST: NM_144639.1 SUBSYSTEM: Histidine Degradation
GENE_ASSOCIATION: NM_006708.1 GENE_LIST: NM_006708.1 SUBSYSTEM: Pyruvate Metabolism
pentadecanoyl carnitine transport (C15:0Crn)
GENE_ASSOCIATION: NM_001010982.1 GENE_LIST: NM_001010982.1 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_000255.1 GENE_LIST: NM_000255.1 SUBSYSTEM: Anaplerotic reactions
glycerol-3-phosphate transport, mitochondrial
glycine passive transport to mitochondria
GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
1-Acyl-sn-glycerol 3-phosphate, human myocyte
GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Glycine and Serine Metabolism
carnitine eicosatetraenoyltransferase (C20:5Crn, n3), mitochondrial
GENE_ASSOCIATION: (NM_006133.1 or NM_139179.1) GENE_LIST: NM_006133.1 NM_139179.1 SUBSYSTEM: Phospholipid Metabolism
carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
CO2 transport (diffusion), mitochondrial
hydroxymethylglutaryl-CoA lyase, mitochondrial
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Aspartate Degradation
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Phenylalanine metabolism
GENE_ASSOCIATION: NM_002539.1 GENE_LIST: NM_002539.1 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: ((NM_001823.3 and NM_001824.2) or NM_001823.3 or NM_001824.2) GENE_LIST: NM_001823.3 NM_001824.2 SUBSYSTEM: Creatine Biosynthesis
GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Metabolism
phosphatidylserine decarboxylase, human myocyte
L-glutamate 5-semialdehyde dehydratase (spontaneous) mitochondrial
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Isoleucine degradation
carnitine eicosatrienoyltransferase (C20:3Crn, n6)
eicosatrienoyl carnitine (C20:3Crn, n-6)
GENE_ASSOCIATION: NM_152435.1 GENE_LIST: NM_152435.1 SUBSYSTEM: Histidine Degradation
carnitine docosahexaenoyltransferase (C22:6Crn, n3)
GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citric Acid Cycle
carnitine pentadecanoyltransferase (C17:0CoA), mitochondrial
fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte
Squalene epoxidase, endoplasmic reticular
GENE_ASSOCIATION: NM_003129.3 GENE_LIST: NM_003129.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_002435.1 GENE_LIST: NM_002435.1 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
GENE_ASSOCIATION: (NM_000031.4 or NM_001003945.1) GENE_LIST: NM_000031.4 NM_001003945.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Anaplerotic reactions
glutamate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: (NM_182977.1 or NM_012343.2) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: Other
fructose transport (uniport: facilitated diffusion)
phosphate transport in/out via proton symporter
GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: (NM_152621.4 or NM_147156.3) GENE_LIST: NM_147156.3 NM_152621.4 SUBSYSTEM: Sphingolipid Metabolism
GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Metabolism
octadecenoyl carnitine transport (C18:1Crn, n9)
GENE_ASSOCIATION: (NM_000291.2 or NM_138733.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: (NM_001040716.1 or NM_022172.1 or NM_000920.2) GENE_LIST: NM_000920.2 NM_001040716.1 NM_022172.1 SUBSYSTEM: Anaplerotic reactions
2-oxoadipate transaminase, mitochondrial
GENE_ASSOCIATION: (NM_016228.3 or NM_182662.1) GENE_LIST: NM_016228.3 NM_182662.1 SUBSYSTEM: Lysine Degradation
GENE_ASSOCIATION: NM_016518.2 GENE_LIST: NM_016518.2 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Metabolism
lathosterol oxidase (NADP), endoplasmic reticulum
GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_000859.1 GENE_LIST: NM_000859.1 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: (NM_002130.4 or NM_001098272.1) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Metabolism
Nucleoside triphosphate pyrophosphorylase (atp)
3-hydroxybutyrate transport in/out via proton symport, blood
GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Purine Metabolism
phosphoribosylformylglycinamidine synthase
L-glutamate 5-semialdehyde dehydratase (spontaneous)
Phosphatidylethanolamine, human hepatocyte
fatty-acid--CoA ligase (eicosapentaenoate, C20:5 n-3)
GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Pyrimidine Metabolism
ribonucleoside-diphosphate reductase (UDP)
3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
alphaketobutyrate transport (mitochondrial)
glutamate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Leucine degradation
GENE_ASSOCIATION: (NM_000613.1 or NM_080669.2) GENE_LIST: NM_000613.1 NM_080669.2 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine metabolism
GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine and Serine Metabolism
stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
GENE_ASSOCIATION: (NM_021727.3 or NM_004265.2) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Biosynthesis
malate oxaloacetate shuttle, mitochondrial
phosphoribosylaminoimidazole carboxylase
fatty acyl-CoA desaturase (C20:4CoA, n3 -> C20:5CoA, n3)
GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Biosynthesis
GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular
eicosatrienoyl carnitine transport (C20:3Crn, n6)
GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)
GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Pyrimidine Catabolism
GENE_ASSOCIATION: (NM_001018073.1 or NM_004563.2) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Aspartate Degradation
Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
GENE_ASSOCIATION: NM_000045.2 GENE_LIST: NM_000045.2 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: (NM_014595.1 or NM_033253.2 or NM_001002006.1) GENE_LIST: NM_001002006.1 NM_014595.1 NM_033253.2 SUBSYSTEM: Pyrimidine Catabolism
GENE_ASSOCIATION: (NM_000309.3 or NM_001122764.1) GENE_LIST: NM_000309.3 NM_001122764.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Metabolism
dihydroorotate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_003038.2 or NM_005628.1 or NM_018018.2) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
L-Glutamate 5-semialdehyde transport, mitochondrial
isopentenyl diphosphate transport, peroxisome
GENE_ASSOCIATION: (NM_001498.2 and NM_002061.2) GENE_LIST: NM_001498.2 NM_002061.2 SUBSYSTEM: Glutathione Metabolism
fatty-acyl-CoA elongation (n-C20:3CoA, n6)
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Extracellular
3-Hydroxy-2-methylpropanoate, proton symporter
GENE_ASSOCIATION: NM_001172.3 GENE_LIST: NM_001172.3 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: (NM_178176.2 or NM_012079.3 or NM_032564.2) GENE_LIST: NM_012079.3 NM_032564.2 NM_178176.2 SUBSYSTEM: Triglycerol Synthesis
GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Methionine Metabolism
GENE_ASSOCIATION: (NM_001007794.1 or NM_020244.2 or NM_006090.3) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Metabolism
diacylglycerol cholinephosphotransferase, human myocyte
carbamoyl-phosphate synthase (glutamine-hydrolysing)
GENE_ASSOCIATION: (NM_058179.2 or NM_021154.3) GENE_LIST: NM_021154.3 NM_058179.2 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
glyceraldehyde-3-phosphate dehydrogenase (NAD)
methylenetetrahydrofolate dehydrogenase (NADP)
Hydroxymethylglutaryl-CoA reversible mitochondrial transport
GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Anaplerotic reactions
GENE_ASSOCIATION: (NM_004493.2 or NM_001037811.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Isoleucine degradation
3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
(R)-3-Hydroxybutanoate:NAD+ oxidoreductase
GENE_ASSOCIATION: (NM_203315.2 or NM_004051.4 or NM_203314.2) GENE_LIST: NM_004051.4 NM_203314.2 NM_203315.2 SUBSYSTEM: Ketone Body Utilization
uroporphyrinogen decarboxylase (uroporphyrinogen III)
GENE_ASSOCIATION: NM_000374.3 GENE_LIST: NM_000374.3 SUBSYSTEM: Heme Biosynthesis
C-14 sterol reductase, endoplasmic reticulum
GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Metabolism
phosphoribosylglycinamide formyltransferase, irreversible
GENE_ASSOCIATION: NM_001150.2 GENE_LIST: NM_001150.2 SUBSYSTEM: Glutathione Metabolism
Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial
bicarbonate transport (Na/HCO3 cotransport), blood
Valine transport, Homo Sapiens passive diffusion
GENE_ASSOCIATION: NM_000672.2 GENE_LIST: NM_000672.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
GENE_ASSOCIATION: NM_001628.2 GENE_LIST: NM_001628.2 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
carnitine hexadecenoyltransferase (C16:1Crn, n7)
ribonucleoside-diphosphate reductase (CDP)
Oleoyl-CoA desaturase (C18:2CoA, n6 -> C18:3CoA, n6)
GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Biosynthesis
nucleoside-diphosphate kinase (ATP:dADP)
Octadecanoate (n-C18:0) transport in via uniport
phosphatidyl-1D-myo-inositol, human hepatocyte
GENE_ASSOCIATION: (NM_005017.2 or NM_004845.3) GENE_LIST: NM_004845.3 NM_005017.2 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: NM_003679.2 GENE_LIST: NM_003679.2 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_170726.1 or NM_003748.2) GENE_LIST: NM_003748.2 NM_170726.1 SUBSYSTEM: Glutamate metabolism
GENE_ASSOCIATION: NM_000791.3 GENE_LIST: NM_000791.3 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: (NM_203488.1 or NM_138448.2 or NM_001107.3) GENE_LIST: NM_001107.3 NM_138448.2 NM_203488.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Citric Acid Cycle
carnitine pentadecanoyltransferase (C17:0Crn)
GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Anaplerotic reactions
Propionyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (NM_148918.1 or NM_004169.3) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Leucine degradation
GENE_ASSOCIATION: NM_003734.2 GENE_LIST: NM_003734.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Pyrimidine Metabolism
Ornithine/citrulline antiport, mitocondiral
GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_001634.4 or NM_001033059.1) GENE_LIST: NM_001033059.1 NM_001634.4 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
octadecadienoyl carnitine (C18:2Crn, n-6)
octadecadienoyl carnitine transferase (C18:2Crn, n6)
GENE_ASSOCIATION: NM_003132.2 GENE_LIST: NM_003132.2 SUBSYSTEM: Arginine Metabolism
fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Metabolism
Phosphatidylserine synthase 1, human myocyte
GENE_ASSOCIATION: (NM_012474.3 or NM_031432.1) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_175085.1 or NM_000819.3) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
ribulose 5-phosphate 3-epimerase, endoplasmic reticulum
GENE_ASSOCIATION: (NM_002396.3 or NM_001014811.1 or NM_006680.2) GENE_LIST: NM_001014811.1 NM_002396.3 NM_006680.2 SUBSYSTEM: Aspartate Degradation
GENE_ASSOCIATION: NM_004901.1 GENE_LIST: NM_004901.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_024698.4 or NM_031481.1) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
L-glutamate reversible transport via proton symport, mitochondrial
GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: (NM_020918.2 or NM_032717.3) GENE_LIST: NM_020918.2 NM_032717.3 SUBSYSTEM: Phospholipid Metabolism
glycerol 3-phosphate acyltransferase, myocyte specific
GENE_ASSOCIATION: (NM_000156.4 or NM_138924.1) GENE_LIST: NM_000156.4 NM_138924.1 SUBSYSTEM: Creatine Biosynthesis
GENE_ASSOCIATION: (NM_001064.1 or NM_012253.2 or NM_032136.3) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Glutamate Metabolism
fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)
GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Metabolism
This model is from the article: A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. BMC Syst Biol. 2011 Oct 31;5(1):180. 22041191 , Abstract: ABSTRACT: BACKGROUND: Genome-scale metabolic reconstructions provide a biologically meaningful mechanis tic basis for the genotype-phenotype relationship. The global human metabolic net work, termed Recon 1, has recently been reconstructed allowing the systems analys is of human metabolic physiology and pathology. Utilizing high-throughput data, R econ 1 has recently been tailored to different cells and tissues, including the l iver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tiss ues has been done. RESULTS: To describe tissue-specific functions, Recon 1 was tailored to describe metabolis m in three human cells: adipocytes, hepatocytes, and myocytes. These cell-specifi c networks were manually curated and validated based on known cellular metabolic functions. To study intercellular interactions, a novel multi-tissue type modelin g approach was developed to integrate the metabolic functions for the three cell types, and subsequently used to simulate known integrated metabolic cycles. In ad dition, the multi-tissue model was used to study diabetes: a pathology with syste mic properties. High-throughput data was integrated with the network to determine differential metabolic activity between obese and type II obese gastric bypass p atients in a whole-body context. CONCLUSION: The multi-tissue type modeling approach presented provides a platform to study in tegrated metabolic states. As more cell and tissue-specific models are released, it is critical to develop a framework in which to study their interdependencies. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
fatty acid transport via diffusion, blood
GENE_ASSOCIATION: NM_005651.1 GENE_LIST: NM_005651.1 SUBSYSTEM: Tryptophan metabolism
L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
Creatine transport to/from mitochondria via diffusion
diacylglycerol pyrophosphate phosphatase, human myocyte
GENE_ASSOCIATION: (NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
formate-tetrahydrofolate ligase, mitochondrial
GENE_ASSOCIATION: NM_007101.2 GENE_LIST: NM_007101.2 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: NM_000531.3 GENE_LIST: NM_000531.3 SUBSYSTEM: Arginine Metabolism
ornithine carbamoyltransferase, mitochondrial
GENE_ASSOCIATION: (NM_199293.2 or NM_199292.2 or NM_000360.3) GENE_LIST: NM_000360.3 NM_199292.2 NM_199293.2 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_024758.3 GENE_LIST: NM_024758.3 SUBSYSTEM: Arginine and Proline Metabolism
GENE_ASSOCIATION: (NM_022120.1 or NM_000436.2) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Leucine degradation
aminocarboxymuconate-semialdehyde decarboxylase
GENE_ASSOCIATION: NM_138326.1 GENE_LIST: NM_138326.1 SUBSYSTEM: Tryptophan metabolism
carnitine octadecatrienoyltransferase (C18:3Crn, n3), mitochondrial
octadecatrienoyl carnitine (C18:3Crn, n3)
GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Glycolysis/ Gluconeogeneis
methylmalonate-semialdehyde dehydrogenase (acylating)
GENE_ASSOCIATION: NM_005589.2 GENE_LIST: NM_005589.2 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: (NM_001024956.1 or NM_006918.3) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Metabolism
lathosterol oxidase (NAD), endoplasmic reticulum
GENE_ASSOCIATION: NM_000375.1 GENE_LIST: NM_000375.1 SUBSYSTEM: Heme Biosynthesis
L-threonine/glycine reversible exchange, blood
GENE_ASSOCIATION: (NM_032136.3 or NM_001064.1 or NM_012253.2) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
docosapentaenoyl carnitine transport (C22:5Crn, n3)
acetoacetate transport via proton symport, blood
GENE_ASSOCIATION: (NM_005763.2 or NM_016002.2) GENE_LIST: NM_005763.2 NM_016002.2 SUBSYSTEM: Lysine Degradation
saccharopine dehydrogenase (NAD, L-glutamate-forming), mitochondrial
GENE_ASSOCIATION: NM_000858.4 GENE_LIST: NM_000858.4 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: (NM_005628.1 or NM_018018.2) GENE_LIST: NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
L-glutamine reversible transport via sodium symport, blood
phosphate peroxisomal transport via proton symport
GENE_ASSOCIATION: NM_001098.2 GENE_LIST: NM_001098.2 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Metabolism
phosphomevalonate kinase, reversible, peroxisome
GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: NM_001182.2 GENE_LIST: NM_001182.2 SUBSYSTEM: Lysine Degradation
L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
acetate mitochondrial transport via proton symport
GENE_ASSOCIATION: (NM_206918.1 or NM_144780.1 or NM_003676.2) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Sphingomyelin
GENE_ASSOCIATION: (NM_023078.1 or NM_013328.2) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
GENE_ASSOCIATION: (NM_001024024.1 or NM_000161.2) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
nucleoside-diphosphate kinase (ATP:dTDP)
GENE_ASSOCIATION: NM_003124.3 GENE_LIST: NM_003124.3 SUBSYSTEM: Tetrahydrobiopterin
GENE_ASSOCIATION: (NM_016335.3 or NM_021232.1) GENE_LIST: NM_016335.3 NM_021232.1 SUBSYSTEM: Proline Metabolism
carnitine hexadecenoyltransferase (C16:1Crn, n7), mitochondrial
ribose-5-phosphate isomerase, endoplasmic reticulum
GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: (NM_020407.1 or NM_000324.1 or NM_016321.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
L-leucine transport via diffusion, blood
L-isoleucine transport via diffusion, blood
GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Metabolism
CDP-diacylglycerol--serine O-phosphatidyltransferase, mitochondrial, human myocyte
GENE_ASSOCIATION: (NM_014362.2 or NM_198047.1) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine degradation
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
phosphogluconate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: NM_001698.1 GENE_LIST: NM_001698.1 SUBSYSTEM: Leucine degradation
fatty-acid--CoA ligase (octadecadienoate, C18:2 n-6)
GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Anaplerotic reactions
glycine reversible transport via sodium symport, blood
L-Serine/Glutamine reversible exchange, blood
aldehyde dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: (NM_000692.3 or NM_000690.2) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine degradation
carnitine octadecenoyltransferase (C18:1Crn, n9)
D-lactate transport via proton symport, blood
GENE_ASSOCIATION: NM_012145.2 GENE_LIST: NM_012145.2 SUBSYSTEM: Pyrimidine Metabolism
methylcrotonoyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Leucine degradation
GENE_ASSOCIATION: (NM_001636.1 or NM_001152.1 or NM_001151.2) GENE_LIST: NM_001151.2 NM_001152.1 NM_001636.1 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_002168.2 GENE_LIST: NM_002168.2 SUBSYSTEM: Citric Acid Cycle
pantetheine-phosphate adenylyltransferase
GENE_ASSOCIATION: (NM_003705.2 or NM_014251.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
cysteinesulfinate-aspartate mitochondrial shuttle
1-Acyl-glycerol-3-phosphate acyltransferase, myocyte specific
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Aspartate Degradation
GENE_ASSOCIATION: (NM_007231.1 or NM_018976.3 or NM_018018.2) GENE_LIST: NM_007231.1 NM_018018.2 NM_018976.3 SUBSYSTEM: Transport, Extracellular
L-histidine transport in via sodium symport, blood
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Leucine degradation
GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: NM_001482.2 GENE_LIST: NM_001482.2 SUBSYSTEM: Creatine Biosynthesis
ubiquinol-6 cytochrome c reductase, Complex III
GENE_ASSOCIATION: (NM_001785.2 or NM_020661.1) GENE_LIST: NM_001785.2 NM_020661.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
C-3 sterol keto reductase (zymosterol), endoplasmic reticulum
inorganic diphosphatase, endoplasmic reticulum
GENE_ASSOCIATION: (NM_006907.2 or NM_153824.1) GENE_LIST: NM_006907.2 NM_153824.1 SUBSYSTEM: Proline Metabolism
GENE_ASSOCIATION: NM_020980.3 GENE_LIST: NM_020980.3 SUBSYSTEM: Transport, Mitochondrial
eicosatetraenoyl carnitine transport (C20:4Crn, n6)
GENE_ASSOCIATION: (NM_015865.2 or NM_007163.3 or NM_020980.3) GENE_LIST: NM_007163.3 NM_015865.2 NM_020980.3 SUBSYSTEM: Transport, Extracellular
Urea transport via facilitate diffusion, blood
aminomuconate-semialdehyde dehydrogenase
carnitine octadecadienoyltransferase (C18:2Crn, n6), mitochondrial
GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Propanoate Metabolism
GENE_ASSOCIATION: NM_001905.1 GENE_LIST: NM_001905.1 SUBSYSTEM: Pyrimidine Metabolism
glucose 6-phosphate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: NM_006755.1 GENE_LIST: NM_006755.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_001012515.1 or NM_000140.2) GENE_LIST: NM_000140.2 NM_001012515.1 SUBSYSTEM: Heme Biosynthesis
pyruvate reversible transport via proton symport, blood
GENE_ASSOCIATION: NM_005984.1 GENE_LIST: NM_005984.1 SUBSYSTEM: Transport, Mitochondrial
L-phenylalanine transport via diffusion (extracellular to cytosol)
myosin-ADP-Pi attachment, myocyte cytosol
GENE_ASSOCIATION: NM_002703.3 GENE_LIST: NM_002703.3 SUBSYSTEM: Purine Metabolism
glutamine phosphoribosyldiphosphate amidotransferase
Leucine transport, Homo Sapiens mitochondria
Lysine mitochondrial transport via ornithine carrier
cardiolipin reversible transport, mitochondria, myocyte
cardiolipin synthase, mitochondrial, myocyte
GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Metabolism
C-3 sterol dehydrogenase NADPH, (4-methylzymosterol)
GENE_ASSOCIATION: (NM_002633.2 or NM_018290.2) GENE_LIST: NM_002633.2 NM_018290.2 SUBSYSTEM: Glycogen Metabolism
GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: NM_000187.2 GENE_LIST: NM_000187.2 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_153742.3 or NM_001902.4) GENE_LIST: NM_001902.4 NM_153742.3 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: NM_000137.1 GENE_LIST: NM_000137.1 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_000507.2 or NM_003837.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
alcohol dehydrogenase (ethanol, NADP), forward reaction
GENE_ASSOCIATION: (NM_153326.1 or NM_006066.2) GENE_LIST: NM_006066.2 NM_153326.1 SUBSYSTEM: Glycolysis/ Gluconeogeneis
GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Metabolism
formaldehyde transport via diffusion (mitochondrial)
nucleoside-diphosphate kinase (ATP:dGDP)
GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Threonine Degradation
glycine C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: NM_000178.2 GENE_LIST: NM_000178.2 SUBSYSTEM: Glutathione Metabolism
GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Isoleucine degradation
methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: (NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
carnitine tetradecanoyltransferase (C14:0Crn)
carnitine octadecanoyltransferase (C18:0Crn)
GENE_ASSOCIATION: NM_003104.3 GENE_LIST: NM_003104.3 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
UTP-glucose-1-phosphate uridylyltransferase
GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3 SUBSYSTEM: Folate Metabolism
methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: NM_004462.3 GENE_LIST: NM_004462.3 SUBSYSTEM: Cholesterol Metabolism
Squalene synthase, endoplasmic reticulum
GENE_ASSOCIATION: (NM_133436.1 or NM_183356.1 or NM_001673.2) GENE_LIST: NM_001673.2 NM_133436.1 NM_183356.1 SUBSYSTEM: Asparagine metabolism
asparagine synthase (glutamine-hydrolysing)
L-cysteine reversible transport via sodium symport, reversible, blood
saccharopine dehydrogenase (NADP, L-lysine-forming), mitochondrial
GENE_ASSOCIATION: NM_005763.2 GENE_LIST: NM_005763.2 SUBSYSTEM: Lysine Degradation
GENE_ASSOCIATION: (NM_001012732.1 or NM_001921.2) GENE_LIST: NM_001012732.1 NM_001921.2 SUBSYSTEM: Pyrimidine Metabolism
C-4 sterol methyl oxidase (4,4-dimethylzymosterol), endoplasmic reticulum
GENE_ASSOCIATION: (NM_000402.2 or NM_001042351.1) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
1-Acyl-sn-glycero-3-phosphocholine, human myocyte specific
carnitine octadecadienoyltransferase (C18:2Crn, n6)
fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
GENE_ASSOCIATION: (NM_005063.4 or NM_001037582.1 or NM_024906.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Biosynthesis
stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-9), adipocyte
GENE_ASSOCIATION: (NM_054012.2 or NM_000050.3) GENE_LIST: NM_000050.3 NM_054012.2 SUBSYSTEM: Arginine Metabolism
eicosatetraenoyl carnitine transport (C20:5Crn, n3)
aldehyde dehydrogenase (acetaldehyde, NAD)
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Phospholipid Metabolism
nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
GENE_ASSOCIATION: (NM_005888.2 or NM_213611.1 or NM_002635.2) GENE_LIST: NM_002635.2 NM_005888.2 NM_213611.1 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Serine metabolism
GENE_ASSOCIATION: NM_018960.4 GENE_LIST: NM_018960.4 SUBSYSTEM: Glycine and Serine Metabolism
GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Purine Metabolism
ribonucleoside-diphosphate reductase (ADP)
L-alanine/glycine reversible exchange, blood
carbonate dehydratase (HCO3 equilibration reaction)
4-aminobutanoate mitochondrial transport via diffusion
phosphoribosylaminoimidazolesuccinocarboxamide synthase
5-Amino-4-oxopentanoate mitochondrial transport
glutamate aspartate carrier, cytosolic/mitochondrial
carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial
GENE_ASSOCIATION: NM_000017.2 GENE_LIST: NM_000017.2 SUBSYSTEM: Butanoate Metabolism
acyl-CoA dehydrogenase (butanoyl-CoA C4:0CoA)
GENE_ASSOCIATION: NM_005518.2 GENE_LIST: NM_005518.2 SUBSYSTEM: Cholesterol Metabolism
L-2-amino-3-oxobutanoate decarboxylation, mitochondrial
glucose transport, endoplasmic reticulum
pentadecanoyl carnitine transferase (C17:0CoA), mitochondrial
GENE_ASSOCIATION: NM_000454.4 GENE_LIST: NM_000454.4 SUBSYSTEM: ROS Detoxification
octadecatrienoyl carnitine transferase (C18:3Crn, n3)
GENE_ASSOCIATION: NM_018238.2 GENE_LIST: NM_018238.2 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: (NM_145870.1 or NM_145871.1 or NM_001513.2) GENE_LIST: NM_001513.2 NM_145870.1 NM_145871.1 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
glucose 6-phosphate endoplasmic reticular transport via diffusion
5,10-Methylenetetrahydrofolate transport, diffusion, mitochondrial
carnitine docosahexaenoyltransferase (C22:6Crn, n3), mitochondrial
GENE_ASSOCIATION: (NM_001170.1 or NM_004925.3) GENE_LIST: NM_001170.1 NM_004925.3 SUBSYSTEM: Transport, Extracellular
glycerol transport in/out via diffusion reversible
formimidoyltetrahydrofolate cyclodeaminase
C-3 sterol dehydrogenase NADH, (4-methylzymosterol)
GENE_ASSOCIATION: (NM_005309.1 or NM_133443.1) GENE_LIST: NM_005309.1 NM_133443.1 SUBSYSTEM: Anaplerotic reactions
Cholesterol transport, endoplasmic reticulum
GENE_ASSOCIATION: NM_006319.3 GENE_LIST: NM_006319.3 SUBSYSTEM: Phospholipid Biosynthesis
phosphatidylinositol synthase, human myocyte
GENE_ASSOCIATION: NM_001159.3 GENE_LIST: NM_001159.3 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: (NM_001077447.1 or NM_024664.2) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
6-Phospho-D-gluconate transport in/out via proton symport
GENE_ASSOCIATION: NM_000097.4 GENE_LIST: NM_000097.4 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: (NM_001039845.1 or NM_005917.2) GENE_LIST: NM_001039845.1 NM_005917.2 SUBSYSTEM: Aspartate Degradation
triacylglycerol hydrolase, human myocyte
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Triglycerol Degradation
GENE_ASSOCIATION: NM_002108.2 GENE_LIST: NM_002108.2 SUBSYSTEM: Histidine Metabolism
GENE_ASSOCIATION: (NM_000167.3 or NM_203391.1) GENE_LIST: NM_000167.3 NM_203391.1 SUBSYSTEM: Glycerophospholipid Metabolism
GENE_ASSOCIATION: (NM_003038.2 or NM_005628.1) GENE_LIST: NM_003038.2 NM_005628.1 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Lysine Degradation
3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)
(R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
ribonucleoside-diphosphate reductase (GDP)
GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: NM_000755.2 GENE_LIST: NM_000755.2 SUBSYSTEM: Carnitine Shuttle
carnitine O-aceyltransferase, mitochondrial
GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Arginine Metabolism
GENE_ASSOCIATION: NM_005891.1 GENE_LIST: NM_005891.1 SUBSYSTEM: Tryptophan metabolism
Eicosatetraenoate (C20:4, n-6) transport
carnitine pentadecanoyltransferase (C15:0Crn)
hydrogen peroxide mitochondrial transport
sodium transport in/out via proton antiport (one H+), blood
GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: (NM_014214.1 or NM_005536.2) GENE_LIST: NM_005536.2 NM_014214.1 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine and Serine Metabolism
phosphopantothenoylcysteine decarboxylase
GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
GENE_ASSOCIATION: (NM_000190.3 or NM_001024382.1) GENE_LIST: NM_000190.3 NM_001024382.1 SUBSYSTEM: Heme Biosynthesis
acyl-coA cholesterol acyltransferase, myocyte
GENE_ASSOCIATION: (NM_003101.4 or NM_003578.3 or (NM_003101.4 and NM_003578.3)) GENE_LIST: NM_003101.4 NM_003578.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: NM_002035.1 GENE_LIST: NM_002035.1 SUBSYSTEM: Sphingolipid Metabolism
GENE_ASSOCIATION: NM_005957.3 GENE_LIST: NM_005957.3 SUBSYSTEM: Folate Metabolism
methylenetetrahydrofolate reductase (NADPH2)
GENE_ASSOCIATION: NM_000320.1 GENE_LIST: NM_000320.1 SUBSYSTEM: Tetrahydrobiopterin
succinate-semialdehyde dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_170740.1 or NM_001080.3) GENE_LIST: NM_001080.3 NM_170740.1 SUBSYSTEM: Glutamate Metabolism
GENE_ASSOCIATION: (NM_006636.3 or NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_006636.3 NM_015440.3 SUBSYSTEM: Folate Metabolism
methenyltetrahydrofolate cyclohydrolase, mitochondrial
carnitine octadecatrienoyltransferase (C18:3Crn, n3)
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Threonine Degradation
GENE_ASSOCIATION: (NM_005609.1 or NM_002863.3 or NM_002862.3) GENE_LIST: NM_002862.3 NM_002863.3 NM_005609.1 SUBSYSTEM: Glycogen Metabolism
octadecanoyl carnitine transport (C18:0Crn)
Glutamine transport, proton coupled, mitochondria
glucose transport (uniport: facilitated diffusion)
fatty acid synthase (n-C8:0), lumped reaction
fatty-acid--CoA ligase (heptadecanoate, C15:0)
GENE_ASSOCIATION: (NM_199229.1 or NM_006916.1) GENE_LIST: NM_006916.1 NM_199229.1 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_001001438.1 or NM_002340.3) GENE_LIST: NM_001001438.1 NM_002340.3 SUBSYSTEM: Cholesterol Metabolism
lanosterol synthase, endoplasmic reticulum
5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
fatty-acyl-CoA elongation (C22:5CoA, n3)
GENE_ASSOCIATION: NM_005896.2 GENE_LIST: NM_005896.2 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: NM_012213.2 GENE_LIST: NM_012213.2 SUBSYSTEM: Fatty Acid Biosynthesis
GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
carnitine pentadecanoyltransferase (C15:0Crn), mitochondria
GENE_ASSOCIATION: (NM_000019.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000019.2 NM_000182.3 NM_000183.1 SUBSYSTEM: Ketone Body Utilization
Biomass Demand, Human Hepatocyte (biosynthesis GAM)
L-lactate reversible transport via proton symport
carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
creatine phosphate dephosphorylation, spontaneous
GENE_ASSOCIATION: (NM_000408.2 or NM_001083112.1) GENE_LIST: NM_000408.2 NM_001083112.1 SUBSYSTEM: Glycerophospholipid Metabolism
glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Isoleucine degradation
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: (NM_001083926.1 or NM_025080.2) GENE_LIST: NM_001083926.1 NM_025080.2 SUBSYSTEM: Asparagine Metabolism
2-oxoadipate shuttle (cytosol/mitochondria)
GENE_ASSOCIATION: NM_030631.1 GENE_LIST: NM_030631.1 SUBSYSTEM: Transport, Mitochondrial
Phospholipase A (phosphatidylcholine), human myocyte specific
arginine mitochondrial transport via ornithine carrier
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Isoleucine degradation
GENE_ASSOCIATION: (NM_007220.2 or NM_001739.1) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Arginine Metabolism
HCO3 equilibration reaction, mitochondrial
GENE_ASSOCIATION: (NM_001096.2 or NM_198830.1) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
carnitine eicosatetraenoyltransferase (C20:4Crn, n6), mitochondrial
GENE_ASSOCIATION: NM_002197.1 GENE_LIST: NM_002197.1 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: (NM_006721.2 or NM_001123.2) GENE_LIST: NM_001123.2 NM_006721.2 SUBSYSTEM: Nucleotides
GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
6-phosphogluconolactonase, endoplasmic reticulum
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Pyrimidine Metabolism
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Arginine and Proline Metabolism
fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
carnitine docosapentaenoyltransferase (C22:5Crn, n3)
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Tyrosine metabolism
CDP-Diacylglycerol synthetase, updated human myocyte
GENE_ASSOCIATION: NM_003818.2 GENE_LIST: NM_003818.2 SUBSYSTEM: Phospholipid Metabolism
fatty acyl-CoA desaturase (C22:5CoA, n3 -> C22:6CoA, n3)
GENE_ASSOCIATION: NM_207315.1 GENE_LIST: NM_207315.1 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: (NM_033261.2 or NM_004508.2) GENE_LIST: NM_004508.2 NM_033261.2 SUBSYSTEM: Cholesterol Metabolism
isopentenyl-diphosphate D-isomerase, peroxisomal
glutamate-5-semialdehyde dehydrogenase, mitochondrial
cytochrome c oxidase (mitochondrial 4 protons/4 cyto)
GENE_ASSOCIATION: (NM_023928.2 or NM_018677.2 or NM_139274.1) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: (NM_013445.3 or NM_000817.2 or NM_000818.1) GENE_LIST: NM_000817.2 NM_000818.1 NM_013445.3 SUBSYSTEM: Glutamate Metabolism
GENE_ASSOCIATION: NM_000254.1 GENE_LIST: NM_000254.1 SUBSYSTEM: Methionine Metabolism
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: (NM_006621.3 or NM_015328.1 or NM_000687.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Methionine Metabolism
phosphoribosylaminoimidazolecarboxamide formyltransferase
glycerol-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
nucleoside-diphosphate kinase (ATP:dCDP)
GENE_ASSOCIATION: NM_005629.1 GENE_LIST: NM_005629.1 SUBSYSTEM: Creatine Biosynthesis
Creatine Na+ symporter, blood to cytosol
L-proline transport, diffusion, mitochondrial
GENE_ASSOCIATION: (NM_001032998.1 or NM_003937.2) GENE_LIST: NM_001032998.1 NM_003937.2 SUBSYSTEM: Tryptophan metabolism
Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-7)
3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) mitochondrial
GENE_ASSOCIATION: (NM_153486.2 or NM_194436.1) GENE_LIST: NM_153486.2 NM_194436.1 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_018976.3 or NM_001077484.1 or NM_030674.2) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
2-Oxoglutarate dehydrogenase complex, mitochondrial
carnitine eicosatetraenoyltransferase (C20:5Crn, n3)