fatty-acid--CoA ligase (heptadecanoate, C15:0)
GENE_ASSOCIATION: (NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
formate-tetrahydrofolate ligase, mitochondrial
saccharopine dehydrogenase (NADP, L-lysine-forming), mitochondrial
GENE_ASSOCIATION: NM_005763.2 GENE_LIST: NM_005763.2 SUBSYSTEM: Lysine Degradation
Nicotinamide adenine dinucleotide phosphate
Nicotinamide adenine dinucleotide phosphate - reduced
GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
carnitine eicosanoyltransferase (C20:0Crn), mitochondria
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Pyruvate Metabolism
SUBSYSTEM: Alanine and Aspartate Metabolism
fatty-acid--CoA ligase (isolinoleate, C18:2 n-9)
GENE_ASSOCIATION: NM_000045.2 GENE_LIST: NM_000045.2 SUBSYSTEM: Urea Cycle
phosphomevalonate kinase, reversible, peroxisome
GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_000019.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000019.2 NM_000182.3 NM_000183.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
acetyl-CoA C-acetyltransferase, mitochondrial
UTP-glucose-1-phosphate uridylyltransferase
GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
5-Amino-4-oxopentanoate mitochondrial transport
GENE_ASSOCIATION: NM_005957.3 GENE_LIST: NM_005957.3 SUBSYSTEM: Nucleotide Metabolism
methylenetetrahydrofolate reductase (NADPH2)
Nicotinamide adenine dinucleotide - reduced
GENE_ASSOCIATION: NM_002435.1 GENE_LIST: NM_002435.1 SUBSYSTEM: Fructose and Mannose Metabolism
carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis
fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)
dodecanoate (C12:0) mammalian cell transport
GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine and Serine Metabolism
HCO3 equilibration reaction, mitochondrial
GENE_ASSOCIATION: (NM_001739.1 or NM_007220.2) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Central Metabolism
octadecatrienoyl carnitine (C18:3Crn, n3)
GENE_ASSOCIATION: (NM_000167.3 or NM_203391.1) GENE_LIST: NM_000167.3 NM_203391.1 SUBSYSTEM: Glycerophospholipid Metabolism
This model is from the article: A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. BMC Syst Biol. 2011 Oct 31;5(1):180. 22041191 , Abstract: ABSTRACT: BACKGROUND: Genome-scale metabolic reconstructions provide a biologically meaningful mechanis tic basis for the genotype-phenotype relationship. The global human metabolic net work, termed Recon 1, has recently been reconstructed allowing the systems analys is of human metabolic physiology and pathology. Utilizing high-throughput data, R econ 1 has recently been tailored to different cells and tissues, including the l iver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tiss ues has been done. RESULTS: To describe tissue-specific functions, Recon 1 was tailored to describe metabolis m in three human cells: adipocytes, hepatocytes, and myocytes. These cell-specifi c networks were manually curated and validated based on known cellular metabolic functions. To study intercellular interactions, a novel multi-tissue type modelin g approach was developed to integrate the metabolic functions for the three cell types, and subsequently used to simulate known integrated metabolic cycles. In ad dition, the multi-tissue model was used to study diabetes: a pathology with syste mic properties. High-throughput data was integrated with the network to determine differential metabolic activity between obese and type II obese gastric bypass p atients in a whole-body context. CONCLUSION: The multi-tissue type modeling approach presented provides a platform to study in tegrated metabolic states. As more cell and tissue-specific models are released, it is critical to develop a framework in which to study their interdependencies. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
Propionyl-CoA carboxylase, mitochondrial
eicosenoyl carnitine transport (C20:1Crn, n9)
GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
Squalene synthase, endoplasmic reticulum
GENE_ASSOCIATION: NM_004462.3 GENE_LIST: NM_004462.3 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_003676.2 or NM_206918.1 or NM_144780.1) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Sphingolipid Metabolism
L-leucine transport via diffusion, blood
GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Metabolism
nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Purine and Pyrimidine Metabolism
phosphopantothenoylcysteine decarboxylase
GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
nucleoside-diphosphate kinase (ATP:dCDP)
GENE_ASSOCIATION: (NM_016002.2 or NM_005763.2) GENE_LIST: NM_005763.2 NM_016002.2 SUBSYSTEM: Lysine Degradation
saccharopine dehydrogenase (NAD, L-glutamate-forming), mitochondrial
Phosphatidylethanolamine, human hepatocyte
Biomass Demand, Human Hepatocyte (biosynthesis GAM)
phosphatidyl-1D-myo-inositol, human hepatocyte
alphaketobutyrate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: (NM_153742.3 or NM_001902.4) GENE_LIST: NM_001902.4 NM_153742.3 SUBSYSTEM: Serine metabolism
GENE_ASSOCIATION: NM_001905.1 GENE_LIST: NM_001905.1 SUBSYSTEM: Nucleotides
GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
phosphate transport in/out via proton symporter
methylcrotonoyl-CoA carboxylase, mitochondrial
GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism
hydrogen peroxide mitochondrial transport
GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
C-4 sterol methyl oxidase (4,4-dimethylzymosterol), endoplasmic reticulum
GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
GENE_ASSOCIATION: (NM_001037811.2 or NM_004493.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
fatty-acid--CoA ligase (heptadecanoate, C17:0)
GENE_ASSOCIATION: NM_018960.4 GENE_LIST: NM_018960.4 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
eicosatrienoyl carnitine transport (C20:3Crn, n9)
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
carnitine O-aceyltransferase, peroxisomal
GENE_ASSOCIATION: NM_004003.2 GENE_LIST: NM_004003.2 SUBSYSTEM: Carnitine Shuttle
Myristoyl-CoA desaturase (n-C14:0CoA -> C14:1CoA, n-7)
GENE_ASSOCIATION: (NM_170740.1 or NM_001080.3) GENE_LIST: NM_001080.3 NM_170740.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
succinate-semialdehyde dehydrogenase, mitochondrial
GENE_ASSOCIATION: NM_000637.2 GENE_LIST: NM_000637.2 SUBSYSTEM: Glutamate metabolism
GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
alphaketobutyrate transport (mitochondrial)
cytochrome P450 lanosterol 14-alpha-demethylase
GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_004092.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Isoleucine degradation
GENE_ASSOCIATION: NM_138326.1 GENE_LIST: NM_138326.1 SUBSYSTEM: Tryptophan metabolism
aminocarboxymuconate-semialdehyde decarboxylase
ribonucleoside-diphosphate reductase (UDP)
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
octadecanoyl carnitine transport (C18:0Crn)
GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
GENE_ASSOCIATION: (NM_000353.1 or NM_002080.2) GENE_LIST: NM_000353.1 NM_002080.2 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Biosynthesis
GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
acetoacetate transport via proton symport, mitochondrial
GENE_ASSOCIATION: NM_005891.1 GENE_LIST: NM_005891.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Alanine and Aspartate Metabolism
GENE_ASSOCIATION: (NM_004925.3 or NM_001170.1) GENE_LIST: NM_001170.1 NM_004925.3 SUBSYSTEM: Transport, Extracellular
glycerol transport in/out via diffusion reversible
GENE_ASSOCIATION: NM_005651.1 GENE_LIST: NM_005651.1 SUBSYSTEM: Tryptophan metabolism
L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)
GENE_ASSOCIATION: (NM_032136.3 or NM_012253.2 or NM_001064.1) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_014595.1 or NM_001002006.1 or NM_033253.2) GENE_LIST: NM_001002006.1 NM_014595.1 NM_033253.2 SUBSYSTEM: Pyrimidine Catabolism
2-oxoadipate shuttle (cytosol/mitochondria)
GENE_ASSOCIATION: NM_030631.1 GENE_LIST: NM_030631.1 SUBSYSTEM: Transport, Mitochondrial
C-14 sterol reductase, endoplasmic reticulum
GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Biosynthesis
carnitine tetradecenoyltransferase (C14:1Crn, n7)
GENE_ASSOCIATION: (NM_000190.3 or NM_001024382.1) GENE_LIST: NM_000190.3 NM_001024382.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: (NM_023928.2 or NM_018677.2 or NM_139274.1) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Pyruvate Metabolism
2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Nucleotides
ubiquinol-6 cytochrome c reductase, Complex III
GENE_ASSOCIATION: (NM_024664.2 or NM_001077447.1) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
eicosanoate transport (n-C20:0), cytosol to blood
eicosatetraenoyl carnitine (C20:4Crn, n-6)
carnitine ocosatetraenoyltransferase (C22:4Crn, n6)
ocosatetraenoyl carnitine (C22:4Crn, n-6)
GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Proline Biosynthesis
GENE_ASSOCIATION: (NM_000436.2 or NM_022120.1) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
GENE_ASSOCIATION: NM_001182.2 GENE_LIST: NM_001182.2 SUBSYSTEM: Lysine Degradation
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
Octadecatrienoate (C18:3, n-3) transport
acetate transport in/out via proton symport
SUBSYSTEM: Vitamins & Cofactor Biosynthesis
methylenetetrahydrofolate dehydrogenase (NADP)
GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Biosynthesis
CDP-Diacylglycerol synthetase, human hepatocyte
eicosanoyl carnitine transport (C20:0Crn)
fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-9)
GENE_ASSOCIATION: (NM_016321.1 or NM_000324.1 or NM_020407.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
Octadecatrienoate (C18:3, n-6) transport
GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Pyrimidine Catabolism
GENE_ASSOCIATION: NM_006319.3 GENE_LIST: NM_006319.3 SUBSYSTEM: Phospholipid Biosynthesis
phosphatidylinositol synthase, human hepatocyte
docosapentaenoyl carnitine (C22:5Crn, n-6)
carnitine docosapentaenoyltransferase (C22:5Crn, n6)
Octadecanoate (n-C18:0) transport in via uniport
eicosapentaenoyl carnitine (C20:5Crn, n-3)
ribonucleoside-diphosphate reductase (ADP)
GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
carnitine tetradecenoyltransferase (C14:1Crn, n7), mitochondrial
carnitine octadecanoyltransferase (C18:0Crn)
carnitine O-palmitoyltransferase (C16:0Crn)
fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_170726.1 or NM_003748.2) GENE_LIST: NM_003748.2 NM_170726.1 SUBSYSTEM: Arginine and Proline Metabolism
4-aminobutyrate transaminase, reversible (mitochondrial)
GENE_ASSOCIATION: (NM_020686.3 or NM_000663.2) GENE_LIST: NM_000663.2 NM_020686.3 SUBSYSTEM: Glutamate Metabolism
GENE_ASSOCIATION: (NM_001921.2 or NM_001012732.1) GENE_LIST: NM_001012732.1 NM_001921.2 SUBSYSTEM: Pyrimidine Catabolism
fatty-acid--CoA ligase (docosanoate, C22:0)
fatty-acid--CoA ligase (eicosapentaenoate, C20:5 n-3)
GENE_ASSOCIATION: NM_000784.2 GENE_LIST: NM_000784.2 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
GENE_ASSOCIATION: NM_003734.2 GENE_LIST: NM_003734.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
eicosatrienoyl carnitine (C20:3Crn, n-6)
carnitine eicosatrienoyltransferase (C20:3Crn, n6)
GENE_ASSOCIATION: (NM_005198.3 or NM_001277.2 or NM_212469.1 or NM_152253.1) GENE_LIST: NM_001277.2 NM_005198.3 NM_152253.1 NM_212469.1 SUBSYSTEM: Glycerophospholipid Metabolism
1-Acyl-glycerol-3-phosphate acyltransferase, hepatocyte specific
1-Acyl-sn-glycerol 3-phosphate, hepatocyte
GENE_ASSOCIATION: NM_001984.1 GENE_LIST: NM_001984.1 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_001096.2 or NM_198830.1) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Citric Acid Cycle
methenyltetrahydrofolate cyclohydrolase, mitochondrial
GENE_ASSOCIATION: (NM_006636.3 or NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_006636.3 NM_015440.3 SUBSYSTEM: Folate Metabolism
ornithine transport via diffusion, blood
carnitine pentadecanoyltransferase (C15:0Crn), mitochondria
GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Inositol Phosphate Metabolism
GENE_ASSOCIATION: (NM_000221.1 or NM_006488.1) GENE_LIST: NM_000221.1 NM_006488.1 SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides
fatty acyl-CoA desaturase (C22:4CoA, n6 -> C22:5CoA, n6)
glutamate dehydrogenase (NADP), mitochondrial
GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Glutamate metabolism
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Other
GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
linoleoyl-CoA desaturase (C18:1CoA,n-9 -> C18:2CoA,n-9)
GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Biosynthesis
carnitine eicosatetraenoyltransferase (C20:4Crn, n6), mitochondrial
carnitine eicosatrienoyltransferase (C20:3Crn, n9)
carnitine docosapentaenoyltransferase (C22:5Crn, n6), mitochondrial
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Triglycerol Degradation
triacylglycerol hydrolase, human hepatocyte
fatty-acid--CoA ligase (eicosenoate, C20:1 n-9)
cardiolipin reversible transport, mitochondria, hepatocyte
GENE_ASSOCIATION: NM_003679.2 GENE_LIST: NM_003679.2 SUBSYSTEM: Tryptophan metabolism
stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-9), adipocyte
GENE_ASSOCIATION: (NM_000161.2 or NM_001024024.1) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
GENE_ASSOCIATION: (NM_013976.2 or NM_000159.2) GENE_LIST: NM_000159.2 NM_013976.2 SUBSYSTEM: Tryptophan metabolism
glutaryl-CoA dehydrogenase, mitochondrial
GENE_ASSOCIATION: (NM_001077484.1 or NM_030674.2 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Biosynthesis
ribonucleoside-diphosphate reductase (GDP)
sodium transport in/out via proton antiport (one H+), blood
GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Amino Acid Metabolism
GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
GENE_ASSOCIATION: (NM_000687.1 or NM_006621.3 or NM_015328.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Methionine Metabolism
fatty-acyl-CoA elongation (C20:2CoA, n9)
GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
cysteinesulfinate-aspartate mitochondrial shuttle
average fatty-acyl CoA, human hepatocyte
Nucleoside triphosphate pyrophosphorylase (atp)
fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
docosapentaenoyl carnitine (C22:5Crn, n-3)
GENE_ASSOCIATION: NM_001098.2 GENE_LIST: NM_001098.2 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citric Acid Cycle
5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial
fatty-acyl-CoA elongation (C20:4CoA, n3)
acyl-coA cholesterol acyltransferase, Hepatocyte
GENE_ASSOCIATION: (NM_003101.4 or (NM_003101.4 and NM_003578.3) or NM_003578.3) GENE_LIST: NM_003101.4 NM_003578.3 SUBSYSTEM: Cholesterol Metabolism
GENE_ASSOCIATION: (NM_000817.2 or NM_013445.3 or NM_000818.1) GENE_LIST: NM_000817.2 NM_000818.1 NM_013445.3 SUBSYSTEM: Valine degradation
phosphoribosylglycinamide formyltransferase, irreversible
GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
methylmalonyl-CoA epimerase, mitochondrial
GENE_ASSOCIATION: NM_002168.2 GENE_LIST: NM_002168.2 SUBSYSTEM: Citric Acid Cycle
GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
taurine transport, uniport (cytosol to peroxisome)
fatty-acyl-CoA elongation (C22:4CoA, n6)
docosahexaenoyl carnitine (C22:6Crn, n-3)
lathosterol oxidase (NAD), endoplasmic reticulum
carnitine pentadecanoyltransferase (C17:0CoA), mitochondrial
lipid, flip-flop intracellular transport
Phospholipase A (phosphatidylcholine), hepatocyte
GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine metabolism
Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial
GENE_ASSOCIATION: (NM_002633.2 or NM_018290.2) GENE_LIST: NM_002633.2 NM_018290.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: (NM_133443.1 or NM_005309.1) GENE_LIST: NM_005309.1 NM_133443.1 SUBSYSTEM: Alanine and Aspartate Metabolism
GENE_ASSOCIATION: (NM_000154.1 or NM_002044.2 or NM_001001556.1) GENE_LIST: NM_000154.1 NM_001001556.1 NM_002044.2 SUBSYSTEM: Galactose Metabolism
GENE_ASSOCIATION: (NM_138733.2 or NM_000291.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Pyrimidine Biosynthesis
GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
Lysine mitochondrial transport via ornithine carrier
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Phenylalanine metabolism
GENE_ASSOCIATION: (NM_001634.4 or NM_001033059.1) GENE_LIST: NM_001033059.1 NM_001634.4 SUBSYSTEM: Arginine and Proline Metabolism
acetoacetate transport via proton symport, blood
malate oxaloacetate shuttle, mitochondrial
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Pyruvate Metabolism
aldehyde dehydrogenase (acetaldehyde, NAD)
GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Nucleotides
glucose transport (uniport: facilitated diffusion)
fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
GENE_ASSOCIATION: NM_005896.2 GENE_LIST: NM_005896.2 SUBSYSTEM: Citrate Cycle (TCA)
fatty-acid--CoA ligase (octadecadienoate, C18:3 n-6)
GENE_ASSOCIATION: (NM_012079.3 or NM_032564.2 or NM_178176.2) GENE_LIST: NM_012079.3 NM_032564.2 NM_178176.2 SUBSYSTEM: Triacylglycerol Synthesis
L-lactate reversible transport via proton symport
SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
phosphatidate reversible transport, mitochondrial, hepatocyte
GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_213611.1 or NM_005888.2 or NM_002635.2) GENE_LIST: NM_002635.2 NM_005888.2 NM_213611.1 SUBSYSTEM: Transport, Mitochondrial
carnitine palmitoyltransferase (C16:0Crn), mitochondrial
GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: (NM_005536.2 or NM_014214.1) GENE_LIST: NM_005536.2 NM_014214.1 SUBSYSTEM: Inositol Phosphate Metabolism
tetradecenoyl carnitine transport (C14:1Crn, n7)
nucleoside-diphosphate kinase (ATP:dGDP)
3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) mitochondrial
GENE_ASSOCIATION: (NM_203314.2 or NM_203315.2 or NM_004051.4) GENE_LIST: NM_004051.4 NM_203314.2 NM_203315.2 SUBSYSTEM: Ketone Body Synthesis
(R)-3-Hydroxybutanoate:NAD+ oxidoreductase
GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
GENE_ASSOCIATION: (NM_001042406.1 or NM_000191.2 or NM_019036.1) GENE_LIST: NM_000191.2 NM_001042406.1 NM_019036.1 SUBSYSTEM: Cholesterol Biosynthesis
hydroxymethylglutaryl-CoA lyase, mitochondrial
Valine transport, Homo Sapiens passive diffusion
GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
aldehyde dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: (NM_000690.2 or NM_000692.3) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_025080.2 or NM_001083926.1) GENE_LIST: NM_001083926.1 NM_025080.2 SUBSYSTEM: Asparagine Metabolism
GENE_ASSOCIATION: (NM_012343.2 or NM_182977.1) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: NAD Metabolism
GENE_ASSOCIATION: (NM_031212.2 or NM_016612.2) GENE_LIST: NM_016612.2 NM_031212.2 SUBSYSTEM: Transport, Mitochondrial
ocosatetraenoyl carnitine transport (C22:4Crn, n6)
octadecatrienoyl carnitine (C18:3Crn, n6)
fatty acid transport via diffusion, blood
SUBSYSTEM: Transport, Endoplasmic Reticular
methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3 SUBSYSTEM: Folate Metabolism
bicarbonate transport (Na/HCO3 cotransport), blood
carnitine eicosatetraenoyltransferase (C20:4Crn, n6)
carnitine dodecanoyltransferase (C12:0Crn)
GENE_ASSOCIATION: NM_000671.3 GENE_LIST: NM_000671.3 SUBSYSTEM: Tyrosine metabolism
S-(hydroxymethyl)glutathione dehydrogenase
L-methionine transport in via sodium symport, blood
docosapentaenoyl carnitine transport (C22:5Crn, n3)
eicosatetraenoyl carnitine transport (C20:4Crn, n6)
GENE_ASSOCIATION: (NM_000402.2 or NM_001042351.1) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
(S)-Methylmalonate semialdehyde transport, mitochondrial
carnitine octadecatrienoyltransferase (C18:3Crn, n3)
GENE_ASSOCIATION: (NM_020661.1 or NM_001785.2) GENE_LIST: NM_001785.2 NM_020661.1 SUBSYSTEM: Pyrimidine Catabolism
GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
aminomuconate-semialdehyde dehydrogenase
hydroxysteroid (17-beta) dehydrogenase 4
GENE_ASSOCIATION: NM_000414.1 GENE_LIST: NM_000414.1 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Biosynthesis
Phosphatidylserine synthase 1, human hepatocyte
glycine reversible transport via sodium symport, blood
GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Amino Acid Metabolism
GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: (NM_001032998.1 or NM_003937.2) GENE_LIST: NM_001032998.1 NM_003937.2 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_000375.1 GENE_LIST: NM_000375.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Biosynthesis
phosphatidylserine decarboxylase, human hepatocyte
GENE_ASSOCIATION: (NM_013267.2 or NM_014905.2) GENE_LIST: NM_013267.2 NM_014905.2 SUBSYSTEM: Glutamate metabolism
CDP-diacylglycerol--serine O-phosphatidyltransferae, mitochondrial, human hepatocyte
GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Biosynthesis
GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fatty acyl-CoA desaturase (C20:4CoA, n3 -> C20:5CoA, n3)
GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Oxidative Phosphorylation
octadecadienoyl carnitine (C18:2Crn, n-6)
GENE_ASSOCIATION: (NM_012474.3 or NM_031432.1) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
cholesterol ester transport, blood, hepatocyte
Tetradecanoate (n-C14:0) transport in via uniport
fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)
GENE_ASSOCIATION: NM_000755.2 GENE_LIST: NM_000755.2 SUBSYSTEM: Carnitine Shuttle
carnitine O-aceyltransferase, mitochondrial
GENE_ASSOCIATION: NM_005989.2 GENE_LIST: NM_005989.2 SUBSYSTEM: Bile Acid Biosynthesis
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
GENE_ASSOCIATION: NM_000320.1 GENE_LIST: NM_000320.1 SUBSYSTEM: Tyrosine metabolism
phosphoribosylaminoimidazole carboxylase
GENE_ASSOCIATION: NM_004391.1 GENE_LIST: NM_004391.1 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: (NM_198324.1 or NM_004077.2) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citric Acid Cycle
S-adenosyl-L-methionine methyltransferase
glutamate aspartate carrier, cytosolic/mitochondrial
GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Folate Metabolism
hexadecenoyl carnitine transprot (C16:1Crn, n7)
GENE_ASSOCIATION: (NM_001126.2 or NM_152328.3 or NM_199165.1) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_001101667.1 or NM_003500.2 or NM_003501.1) GENE_LIST: NM_001101667.1 NM_003500.2 NM_003501.1 SUBSYSTEM: Bile Acid Biosynthesis
acyl-Coenzyme A oxidase 2, branched chain
C-3 sterol dehydrogenase NADPH, (4-methylzymosterol)
GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Biosynthesis
pentadecanoyl carnitine transferase (C17:0CoA), mitochondrial
GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Pyruvate Metabolism
3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
GENE_ASSOCIATION: NM_000097.4 GENE_LIST: NM_000097.4 SUBSYSTEM: Heme Biosynthesis
aspartate carbamoyltransferase (reversible)
carnitine eicosanoyltransferase (C20:0Crn)
Eicosatetraenoate (C20:4, n-3) transport
dimethylallyl diphosphate transport, peroxisome
carnitine eicosatetraenoyltransferase (C20:5Crn, n3), mitochondrial
GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
carnitine pentadecanoyltransferase (C17:0Crn)
GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
glucose 6-phosphate endoplasmic reticular transport via diffusion
GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
L-phenylalanine transport via diffusion (extracellular to cytosol)
pyruvate reversible transport via proton symport, blood
CO2 transport (diffusion), mitochondrial
carbamoyl-phosphate synthase (glutamine-hydrolysing)
GENE_ASSOCIATION: (NM_001513.2 or NM_145871.1 or NM_145870.1) GENE_LIST: NM_001513.2 NM_145870.1 NM_145871.1 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: (NM_001123.2 or NM_006721.2) GENE_LIST: NM_001123.2 NM_006721.2 SUBSYSTEM: Purine Metabolism
GENE_ASSOCIATION: NM_000859.1 GENE_LIST: NM_000859.1 SUBSYSTEM: Cholesterol Biosynthesis
carnitine tetradecanoyltransferase (C14:0Crn)
octadecatrienoyl carnitine transferase (C18:3Crn, n3)
GENE_ASSOCIATION: (NM_000578.2 or NM_014585.3 or NM_000617.1) GENE_LIST: NM_000578.2 NM_000617.1 NM_014585.3 SUBSYSTEM: Transport, Extracellular
fatty-acid--CoA ligase (ocosatetraenoate, C22:4 n-6)
Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-7)
3-hydroxybutyrate transport in/out via proton symport, blood
alcohol dehydrogenase (ethanol, NADP), forward reaction
GENE_ASSOCIATION: (NM_006066.2 or NM_153326.1) GENE_LIST: NM_006066.2 NM_153326.1 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: NM_003645.2 GENE_LIST: NM_003645.2 SUBSYSTEM: Bile Acid Biosynthesis
SUBSYSTEM: Glycerophospholipid Metabolism
GENE_ASSOCIATION: NM_001752.2 GENE_LIST: NM_001752.2 SUBSYSTEM: Other
GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Biosynthesis
glyceraldehyde-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_002197.1 GENE_LIST: NM_002197.1 SUBSYSTEM: Citric Acid Cycle
(R)-3-Hydroxybutanoate mitochondrial transport via H+ symport
acetate mitochondrial transport via proton symport
diacylglycerol pyrophosphate phosphatase, human hepatocyte
GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Sterol Biosynthesis
fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-3)
GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
carnitine octadecadienoyltransferase (C18:2Crn, n6), mitochondrial
GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Cysteine Metabolism
GENE_ASSOCIATION: (NM_175859.1 or NM_019857.3) GENE_LIST: NM_019857.3 NM_175859.1 SUBSYSTEM: Pyrimidine Biosynthesis
GENE_ASSOCIATION: (NM_000360.3 or NM_199292.2 or NM_199293.2) GENE_LIST: NM_000360.3 NM_199292.2 NM_199293.2 SUBSYSTEM: Tyrosine metabolism
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Tyrosine metabolism
pentadecanoyl carnitine transport (C15:0Crn)
C-3 sterol dehydrogenase NADH, (4-methylzymosterol)
6-phosphogluconolactonase, endoplasmic reticulum
GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
carnitine octadecatrienoyltransferase (C18:3Crn, n3), mitochondrial
GENE_ASSOCIATION: (NM_003038.2 or NM_018018.2 or NM_005628.1) GENE_LIST: NM_003038.2 NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: (NM_203382.1 or NM_014324.4) GENE_LIST: NM_014324.4 NM_203382.1 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_000155.2 GENE_LIST: NM_000155.2 SUBSYSTEM: Galactose Metabolism
UDPglucose--hexose-1-phosphate uridylyltransferase
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
GENE_ASSOCIATION: NM_025193.2 GENE_LIST: NM_025193.2 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_001701.2 GENE_LIST: NM_001701.2 SUBSYSTEM: Bile Acid Biosynthesis
bile acid Coenzyme A: amino acid N-acyltransferase
Docosapentaenoate (C22:5, n-6) transport
glycerol-3-phosphate dehydrogenase (NAD)
GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
GENE_ASSOCIATION: (NM_032717.3 or NM_020918.2) GENE_LIST: NM_020918.2 NM_032717.3 SUBSYSTEM: Phospholipid Biosynthesis
glycerol 3-phosphate acyltransferase, hepatocyte specific
GENE_ASSOCIATION: NM_000255.1 GENE_LIST: NM_000255.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
octadecatrienoyl carnitine transferase (C18:3Crn, n6)
formimidoyltetrahydrofolate cyclodeaminase
GENE_ASSOCIATION: (NM_206965.1 or NM_006657.2) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
fatty-acid--CoA ligase (eicosanoate, C20:0)
GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_016228.3 or NM_182662.1) GENE_LIST: NM_016228.3 NM_182662.1 SUBSYSTEM: Citric Acid Cycle
2-oxoadipate transaminase, mitochondrial
carnitine docosahexaenoyltransferase (C22:6Crn, n3)
GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Tryptophan metabolism
3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA)
Eicosapentaenoate (C20:5, n-3) transport
Squalene epoxidase, endoplasmic reticular
GENE_ASSOCIATION: NM_003129.3 GENE_LIST: NM_003129.3 SUBSYSTEM: Cholesterol Biosynthesis
tetradecanoyl carnitine transport (C14:0Crn)
carnitine pentadecanoyltransferase (C15:0Crn)
octadecenoyl carnitine transport (C18:1Crn, n9)
fatty-acid--CoA ligase (octadecadienoate, C18:3 n-3), hepatocyte
GENE_ASSOCIATION: NM_000187.2 GENE_LIST: NM_000187.2 SUBSYSTEM: Tyrosine metabolism
Leucine transport, Homo Sapiens mitochondria
GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Nucleotides
GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
GENE_ASSOCIATION: NM_003124.3 GENE_LIST: NM_003124.3 SUBSYSTEM: Folate Metabolism
GENE_ASSOCIATION: (NM_148918.1 or NM_004169.3) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Serine metabolism
docosahexaenoyl carnitine transport (C22:6Crn, n3)
isopentenyl diphosphate transport, peroxisome
phosphate peroxisomal transport via proton symport
eicosatrienoyl carnitine transport (C20:3Crn, n6)
glutamate dehydrogenase (NAD), mitochondrial
GENE_ASSOCIATION: (NM_001098486.1 or NM_006632.3 or NM_020309.2) GENE_LIST: NM_001098486.1 NM_006632.3 NM_020309.2 SUBSYSTEM: Transport, Endoplasmic Reticular
phosphate transporter, endoplasmic reticulum
stearoyl-CoA desaturase (n-C20:0CoA -> C20:1CoA, n-9)
6-Phospho-D-gluconate transport in/out via proton symport
GENE_ASSOCIATION: (NM_000408.2 or NM_001083112.1) GENE_LIST: NM_000408.2 NM_001083112.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
glycerol-3-phosphate dehydrogenase (FAD), mitochondrial
GENE_ASSOCIATION: (NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Folate Metabolism
methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
dihydroorotate dehydrogenase (mitochondrial)
GENE_ASSOCIATION: NM_001025193.1 GENE_LIST: NM_001025193.1 SUBSYSTEM: Nucleotide Metabolism
nucleoside-diphosphate kinase (ATP:dTDP)
GENE_ASSOCIATION: (NM_000309.3 or NM_001122764.1) GENE_LIST: NM_000309.3 NM_001122764.1 SUBSYSTEM: Heme Biosynthesis
Oleoyl-CoA desaturase (C18:2CoA, n6 -> C18:3CoA, n6)
GENE_ASSOCIATION: (NM_003849.1 and NM_003850.1) GENE_LIST: NM_003849.1 NM_003850.1 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: (NM_000340.1 or NM_006516.1) GENE_LIST: NM_000340.1 NM_006516.1 SUBSYSTEM: Transport, Extracellular
fatty acyl-CoA desaturase (C22:5CoA, n3 -> C22:6CoA, n3)
GENE_ASSOCIATION: NM_000254.1 GENE_LIST: NM_000254.1 SUBSYSTEM: Methionine Metabolism
GENE_ASSOCIATION: NM_005518.2 GENE_LIST: NM_005518.2 SUBSYSTEM: Cholesterol Biosynthesis
GENE_ASSOCIATION: (NM_005917.2 or NM_001039845.1) GENE_LIST: NM_001039845.1 NM_005917.2 SUBSYSTEM: Citrate Cycle (TCA)
GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
phosphoribosylformylglycinamidine synthase
Ceramide cholinephosphotransferase, hepatocyte
GENE_ASSOCIATION: NM_000858.4 GENE_LIST: NM_000858.4 SUBSYSTEM: Nucleotides
L-glutamine reversible transport via sodium symport, blood
GENE_ASSOCIATION: (NM_018018.2 or NM_005628.1) GENE_LIST: NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
GENE_ASSOCIATION: NM_003132.2 GENE_LIST: NM_003132.2 SUBSYSTEM: beta-Alanine metabolism
phosphatidylglycerol phosphate phosphatase A, mitochondrial, human hepatocyte
GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
GENE_ASSOCIATION: (NM_001098272.1 or NM_002130.4) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Biosynthesis
fatty-acid--CoA ligase (tetradecenoate, C14:1 n-7)
GENE_ASSOCIATION: NM_002539.1 GENE_LIST: NM_002539.1 SUBSYSTEM: Urea Cycle
4-aminobutanoate mitochondrial transport via diffusion
GENE_ASSOCIATION: (NM_018018.2 or NM_018976.3 or NM_007231.1) GENE_LIST: NM_007231.1 NM_018018.2 NM_018976.3 SUBSYSTEM: Transport, Extracellular
L-histidine transport in via sodium symport, blood
tyrosine mitochondrial transport via proton symport
3-hydroxyisobutyrate dehydrogenase, mitochondrial
GENE_ASSOCIATION: NM_152740.2 GENE_LIST: NM_152740.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_000791.3 GENE_LIST: NM_000791.3 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
fatty-acid--CoA ligase (octadecadienoate, C18:2 n-6)
GENE_ASSOCIATION: (NM_033261.2 or NM_004508.2) GENE_LIST: NM_004508.2 NM_033261.2 SUBSYSTEM: Cholesterol Biosynthesis
isopentenyl-diphosphate D-isomerase, peroxisomal
L-Glutamate 5-semialdehyde transport, mitochondrial
L-isoleucine transport via diffusion, blood
GENE_ASSOCIATION: (NM_024698.4 or NM_031481.1) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
L-glutamate reversible transport via proton symport, mitochondrial
GENE_ASSOCIATION: (NM_001079525.1 or NM_001079524.1 or NM_006452.3) GENE_LIST: NM_001079524.1 NM_001079525.1 NM_006452.3 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
phosphoribosylaminoimidazolesuccinocarboxamide synthase
GENE_ASSOCIATION: NM_001010982.1 GENE_LIST: NM_001010982.1 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_147156.3 GENE_LIST: NM_147156.3 SUBSYSTEM: Sphingolipid Metabolism
Ceramide cholinephosphotransferase, human hepatocyte
GENE_ASSOCIATION: NM_144607.2 GENE_LIST: NM_144607.2 SUBSYSTEM: Pyruvate Metabolism
D-lactate dehydrogenase, cytosolic/mitochondrial
phosphoribosylaminoimidazolecarboxamide formyltransferase
GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine Metabolism
dodecanoyl carnitine transport (C12:0Crn)
fatty-acyl-CoA elongation (n-C20:3CoA, n6)
GENE_ASSOCIATION: NM_000374.3 GENE_LIST: NM_000374.3 SUBSYSTEM: Heme Biosynthesis
uroporphyrinogen decarboxylase (uroporphyrinogen III)
eicosatetraenoyl carnitine transport (C20:5Crn, n3)
carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial
GENE_ASSOCIATION: NM_002035.1 GENE_LIST: NM_002035.1 SUBSYSTEM: Sphingolipid Metabolism
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
GENE_ASSOCIATION: (NM_198047.1 or NM_014362.2) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine degradation
GENE_ASSOCIATION: (NM_005609.1 or NM_002862.3 or NM_002863.3) GENE_LIST: NM_002862.3 NM_002863.3 NM_005609.1 SUBSYSTEM: Starch and Sucrose Metabolism
cytochrome P450, family 7, subfamily A, polypeptide 1
GENE_ASSOCIATION: NM_000780.2 GENE_LIST: NM_000780.2 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_001159.3 GENE_LIST: NM_001159.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
GENE_ASSOCIATION: NM_152435.1 GENE_LIST: NM_152435.1 SUBSYSTEM: Histidine Metabolism
GENE_ASSOCIATION: (NM_023078.1 or NM_013328.2) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
carnitine ocosatetraenoyltransferase (C22:4Crn, n6), mitochondrial
L-proline transport, diffusion, mitochondrial
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
GENE_ASSOCIATION: NM_001818.2 GENE_LIST: NM_001818.2 SUBSYSTEM: Bile Acid Biosynthesis
L-glutamate 5-semialdehyde dehydratase (spontaneous)
carnitine-propcarnitine carrier, peroxisomal
GENE_ASSOCIATION: (NM_058179.2 or NM_021154.3) GENE_LIST: NM_021154.3 NM_058179.2 SUBSYSTEM: Glycine and Serine Metabolism
carnitine octadecanoyltransferase (C18:0Crn), mitochondria
carnitine eicosatrienoyltransferase (C20:3Crn, n9), mitochondrial
GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
glycine passive transport to mitochondria
D-Fructose 1-phosphate D-glyceraldehyde-3-phosphate-lyase
glutamate-5-semialdehyde dehydrogenase, mitochondrial
fatty-acyl-CoA elongation (C22:5CoA, n3)
GENE_ASSOCIATION: NM_000137.1 GENE_LIST: NM_000137.1 SUBSYSTEM: Tyrosine metabolism
carnitine eicosenoyltransferase (C20:1Crn, n9), mitochondrial
GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
docosapentaenoyl carnitine transport (C22:5Crn, n6)
L-2-amino-3-oxobutanoate decarboxylation, mitochondrial
GENE_ASSOCIATION: NM_006708.1 GENE_LIST: NM_006708.1 SUBSYSTEM: Pyruvate Metabolism
GENE_ASSOCIATION: (NM_031947.2 or NM_014252.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
Hydroxymethylglutaryl-CoA reversible mitochondrial transport
GENE_ASSOCIATION: NM_001007098.1 GENE_LIST: NM_001007098.1 SUBSYSTEM: Bile Acid Biosynthesis
GENE_ASSOCIATION: NM_018677.2 GENE_LIST: NM_018677.2 SUBSYSTEM: Phospholipid Metabolism
GENE_ASSOCIATION: NM_004901.1 GENE_LIST: NM_004901.1 SUBSYSTEM: Nucleotides
carnitine eicosenoyltransferase (C20:1Crn, n9)
fatty-acid--CoA ligase (eicosadienoate, C20:2 n-9)
GENE_ASSOCIATION: (NM_001498.2 and NM_002061.2) GENE_LIST: NM_001498.2 NM_002061.2 SUBSYSTEM: Cysteine Metabolism
carnitine octadecenoyltransferase (C18:1Crn, n9)
inorganic diphosphatase, endoplasmic reticulum
GENE_ASSOCIATION: (NM_006657.2 or NM_206965.1) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Folate Metabolism
carbonate dehydratase (HCO3 equilibration reaction)
carnitine octadecadienoyltransferase (C18:2Crn, n6)
SUBSYSTEM: Fructose and Mannose Metabolism
GENE_ASSOCIATION: NM_000531.3 GENE_LIST: NM_000531.3 SUBSYSTEM: Urea Cycle
ornithine carbamoyltransferase, mitochondrial
3-(4-hydroxyphenyl)pyruvate mitochondrial transport via proton symport
carnitine docosapentaenoyltransferase (C22:5Crn, n3)
GENE_ASSOCIATION: NM_002108.2 GENE_LIST: NM_002108.2 SUBSYSTEM: Histidine Degradation
L-cysteine reversible transport via sodium symport, reversible, blood
octadecadienoyl carnitine transferase (C18:2Crn, n6)
L-glutamate 5-semialdehyde dehydratase (spontaneous) mitochondrial
GENE_ASSOCIATION: (NM_000031.4 or NM_001003945.1) GENE_LIST: NM_000031.4 NM_001003945.1 SUBSYSTEM: Heme Biosynthesis
2-Oxoglutarate dehydrogenase complex, mitochondrial
Eicosatetraenoate (C20:4, n-6) transport
GENE_ASSOCIATION: ((NM_004863.2 and NM_178324.1) or (NM_004863.2 and NM_006415.2)) GENE_LIST: NM_004863.2 NM_006415.2 NM_178324.1 SUBSYSTEM: Sphingolipid Metabolism
fructose transport (uniport: facilitated diffusion)
GENE_ASSOCIATION: NM_012145.2 GENE_LIST: NM_012145.2 SUBSYSTEM: Nucleotides
2-oxoglutarate dehydrogenase, mitochondrial
GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine and Proline Metabolism
eicosadienoyl-CoA desaturase (C20:2CoA,n-9 -> C20:3CoA,n-9)
GENE_ASSOCIATION: (NM_012145.2 or NM_016308.1) GENE_LIST: NM_012145.2 NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
cytochrome c oxidase (mitochondrial 4 protons/4 cyto)
GENE_ASSOCIATION: (NM_006907.2 or NM_153824.1) GENE_LIST: NM_006907.2 NM_153824.1 SUBSYSTEM: Amino Acid Metabolism
GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Biosynthesis
glucose transport, endoplasmic reticulum
D-lactate transport via proton symport, blood
carnitine hexadecenoyltransferase (C16:1Crn, n7), mitochondrial
GENE_ASSOCIATION: (NM_020244.2 or NM_001007794.1 or NM_006090.3) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Biosynthesis
diacylglycerol cholinephosphotransferase, human hepatocyte
glycerol-3-phosphate transport, mitochondrial
GENE_ASSOCIATION: (NM_003837.2 or NM_000507.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
GENE_ASSOCIATION: NM_016518.2 GENE_LIST: NM_016518.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
Glutamine transport, proton coupled, mitochondria
5,10-Methylenetetrahydrofolate transport, diffusion, mitochondrial
GENE_ASSOCIATION: (NM_004845.3 or NM_005017.2) GENE_LIST: NM_004845.3 NM_005017.2 SUBSYSTEM: Fatty Acid Synthesis
L-asparagine transport in via sodium symport, blood
GENE_ASSOCIATION: (NM_001012515.1 or NM_000140.2) GENE_LIST: NM_000140.2 NM_001012515.1 SUBSYSTEM: Heme Biosynthesis
GENE_ASSOCIATION: (NM_000050.3 or NM_054012.2) GENE_LIST: NM_000050.3 NM_054012.2 SUBSYSTEM: Urea Cycle
GENE_ASSOCIATION: NM_005984.1 GENE_LIST: NM_005984.1 SUBSYSTEM: Transport, Mitochondrial
GENE_ASSOCIATION: (NM_001151.2 or NM_001636.1 or NM_001152.1) GENE_LIST: NM_001151.2 NM_001152.1 NM_001636.1 SUBSYSTEM: Transport, Mitochondrial
carnitine dodecanoyltransferase (C12:0Crn), mitochondria
Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
GENE_ASSOCIATION: (NM_001018073.1 or NM_004563.2) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
GENE_ASSOCIATION: (NM_021727.3 or NM_004265.2) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
glucose 6-phosphate dehydrogenase, endoplasmic reticulum
GENE_ASSOCIATION: NM_003818.2 GENE_LIST: NM_003818.2 SUBSYSTEM: Phospholipid Biosynthesis
CDP-Diacylglycerol synthetase, mitochondrial, human hepatocyte
GENE_ASSOCIATION: NM_005504.4 GENE_LIST: NM_005504.4 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
carnitine hexadecenoyltransferase (C16:1Crn, n7)
Cholesterol transport, endoplasmic reticulum
GENE_ASSOCIATION: (NM_199229.1 or NM_006916.1) GENE_LIST: NM_006916.1 NM_199229.1 SUBSYSTEM: Pentose Phosphate Pathway
nucleoside-diphosphate kinase (ATP:dADP)
3',5'-cyclic-nucleotide phosphodiesterase
glycine C-acetyltransferase, mitochondrial
GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
carnitine octadecatrienoyltransferase (C18:3Crn, n6)
GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Alanine and Aspartate Metabolism
pantetheine-phosphate adenylyltransferase
GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Phenylalanine metabolism
ribonucleoside-diphosphate reductase (CDP)
Ornithine/citrulline antiport, mitocondiral
GENE_ASSOCIATION: NM_144639.1 GENE_LIST: NM_144639.1 SUBSYSTEM: Histidine Metabolism
GENE_ASSOCIATION: NM_012205.1 GENE_LIST: NM_012205.1 SUBSYSTEM: Tryptophan metabolism
GENE_ASSOCIATION: NM_001698.1 GENE_LIST: NM_001698.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
C-3 sterol keto reductase (zymosterol), endoplasmic reticulum
GENE_ASSOCIATION: (NM_001001438.1 or NM_002340.3) GENE_LIST: NM_001001438.1 NM_002340.3 SUBSYSTEM: Cholesterol Biosynthesis
lanosterol synthase, endoplasmic reticulum
GENE_ASSOCIATION: (NM_001673.2 or NM_133436.1 or NM_183356.1) GENE_LIST: NM_001673.2 NM_133436.1 NM_183356.1 SUBSYSTEM: Alanine and Aspartate Metabolism
asparagine synthase (glutamine-hydrolysing)
GENE_ASSOCIATION: NM_000672.2 GENE_LIST: NM_000672.2 SUBSYSTEM: Pyruvate Metabolism
alcohol dehydrogenase, forward rxn (ethanol -> acetaldehyde)
GENE_ASSOCIATION: (NM_020980.3 or NM_007163.3 or NM_015865.2) GENE_LIST: NM_007163.3 NM_015865.2 NM_020980.3 SUBSYSTEM: Transport, Extracellular
Urea transport via facilitate diffusion, blood
GENE_ASSOCIATION: NM_000454.4 GENE_LIST: NM_000454.4 SUBSYSTEM: ROS Detoxification
fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
carnitine octadecatrienoyltransferase (C18:3Crn, n6), mitochondrial
fatty-acid--CoA ligase (docosapentaenoate, C22:5 n-3)
GENE_ASSOCIATION: NM_006755.1 GENE_LIST: NM_006755.1 SUBSYSTEM: Pentose Phosphate Pathway
carnitine docosahexaenoyltransferase (C22:6Crn, n3), mitochondrial
carnitine eicosatetraenoyltransferase (C20:5Crn, n3)
GENE_ASSOCIATION: NM_002703.3 GENE_LIST: NM_002703.3 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
glutamine phosphoribosyldiphosphate amidotransferase
lathosterol oxidase (NADP), endoplasmic reticulum
GENE_ASSOCIATION: NM_207315.1 GENE_LIST: NM_207315.1 SUBSYSTEM: Nucleotides
nucleoside-diphosphate kinase (ATP:dUDP)
GENE_ASSOCIATION: NM_000178.2 GENE_LIST: NM_000178.2 SUBSYSTEM: Glutathione Metabolism
fatty-acid--CoA ligase (dodecanoate, C12:0)