MODEL1111070001
type: SBMLModel
species: 871203
species: 871421
reaction: 913593
reaction: 927981
reaction: 963399
reaction: 956118
reaction: 899515
species: 864236
reaction: 962397
species: 871869
reaction: 887208
reaction: 914603
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reaction: 888817
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reaction: 958135
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reaction: 882096
reaction: 930269
reaction: 881019
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reaction: 964291
reaction: 945567
species: 868541
species: 868048
species: 870263
reaction: 924003
species: 865907
species: 870935
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species: 865787
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species: 870335
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reaction: 900599
reaction: 909696
species: 866064
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reaction: 908348
reaction: 877569
species: 868927
reaction: 960187
reaction: 964037
reaction: 937151
species: 870623
reaction: 934277
notes: This model is from the article: A multi-tissue type genome-scale metabolic network for analysis of whole-body systems physiology. Bordbar A, Feist AM, Usaite-Black R, Woodcock J, Palsson BO, Famili I. BMC Syst Biol. 2011 Oct 31;5(1):180. 22041191 , Abstract: ABSTRACT: BACKGROUND: Genome-scale metabolic reconstructions provide a biologically meaningful mechanis tic basis for the genotype-phenotype relationship. The global human metabolic net work, termed Recon 1, has recently been reconstructed allowing the systems analys is of human metabolic physiology and pathology. Utilizing high-throughput data, R econ 1 has recently been tailored to different cells and tissues, including the l iver, kidney, brain, and alveolar macrophage. These models have shown utility in the study of systems medicine. However, no integrated analysis between human tiss ues has been done. RESULTS: To describe tissue-specific functions, Recon 1 was tailored to describe metabolis m in three human cells: adipocytes, hepatocytes, and myocytes. These cell-specifi c networks were manually curated and validated based on known cellular metabolic functions. To study intercellular interactions, a novel multi-tissue type modelin g approach was developed to integrate the metabolic functions for the three cell types, and subsequently used to simulate known integrated metabolic cycles. In ad dition, the multi-tissue model was used to study diabetes: a pathology with syste mic properties. High-throughput data was integrated with the network to determine differential metabolic activity between obese and type II obese gastric bypass p atients in a whole-body context. CONCLUSION: The multi-tissue type modeling approach presented provides a platform to study in tegrated metabolic states. As more cell and tissue-specific models are released, it is critical to develop a framework in which to study their interdependencies. To the extent possible under law, all copyright and related or neighbouring rights to this enc…
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reaction: 953415
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reaction: 959510
reaction: 897816
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species: 867456
reaction: 965579
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reaction: 907638
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reaction: 923049
reaction: 885137
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reaction: 937392
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reaction: 949283
reaction: 959122
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species: 868505
reaction: 949763
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reaction: 963242

871203
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initial concentration: NaN
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in compartment: 863981
name: 4-Methylzymosterol intermediate 1

863981
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Endoplasmic_reticulum

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type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Lathosterol

913593
type: Reaction
reactant: 913617
product: 913641
reactant: 913629
name: fatty-acid--CoA ligase (heptadecanoate, C15:0)
product: 913665
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reversible: true
fast: false
kinetic law: 913677
reactant: 913605
product: 913653

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species: 868469

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name: pentadecanoate (C15:0)

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species: 868361

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name: Diphosphate

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name: pentadecanoyl-CoA (C15:0CoA)

927981
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reactant: 928017
product: 928054
product: 928042
reactant: 927993
product: 928030
kinetic law: 928066
fast: false
notes: GENE_ASSOCIATION: (NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_015440.3 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
name: formate-tetrahydrofolate ligase, mitochondrial
reactant: 928005
reversible: true

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name: 5,6,7,8-Tetrahydrofolate

863969
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spatial dimensions: 3.0
name: Mitochondrion

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name: Phosphate

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initial concentration: NaN
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name: ADP

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name: ATP

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initial concentration: NaN
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in compartment: 863969
name: 10-Formyltetrahydrofolate

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value: 0.0

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species: 870005

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initial concentration: NaN
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in compartment: 863969
name: Formate

963399
type: Reaction
name: saccharopine dehydrogenase (NADP, L-lysine-forming), mitochondrial
notes: GENE_ASSOCIATION: NM_005763.2 GENE_LIST: NM_005763.2 SUBSYSTEM: Lysine Degradation
reactant: 963423
kinetic law: 963496
reversible: false
product: 963460
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fast: false
reactant: 963411

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in compartment: 863969
name: H+

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name: L-Saccharopine

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species: 870347

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name: L-Lysine

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species: 870474

870474
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name: Nicotinamide adenine dinucleotide phosphate

963472
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species: 870152

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: H2O

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species: 870487

870487
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initial concentration: NaN
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in compartment: 863969
name: Nicotinamide adenine dinucleotide phosphate - reduced

963411
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species: 869448

869448
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 2-Oxoglutarate

956118
type: Reaction
reactant: 956142
fast: false
reversible: false
notes: GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
product: 956155
product: 956167
reactant: 956130
kinetic law: 956179
name: 6-phosphogluconolactonase

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name: H2O

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865291
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initial concentration: NaN
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in compartment: 863957
name: 6-Phospho-D-gluconate

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species: 867216

867216
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name: H+

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species: 865303

865303
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 6-phospho-D-glucono-1,5-lactone

956227
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956203
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956191
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899515
type: Reaction
reversible: true
product: 899563
reactant: 899539
reactant: 899527
product: 899551
kinetic law: 899575
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosanoyltransferase (C20:0Crn), mitochondria
fast: false

899563
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species: 869787

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name: Eicosanoyl-CoA (n-C20:0CoA)

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species: 869800

869800
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name: eicosanoylcarnitine, C20:0crn

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species: 869643

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in compartment: 863969
name: Coenzyme A

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869655
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boundary condition: false
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initial concentration: NaN
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name: L-Carnitine

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value: 0.0

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value: 1000.0

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864236
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initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosapentaenoate (C20:5, n-3)

864005
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Blood

962397
type: Reaction
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Pyruvate Metabolism
reversible: false
reactant: 962421
product: 962433
reactant: 962409
fast: false
product: 962445
name: pyruvate transport, mitochondrial
kinetic law: 962457

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species: 868493

868493
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Pyruvate

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species: 870140

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stoichiometry: 1.0
species: 867216

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species: 870911

870911
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Pyruvate

962507
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value: 500.0

962494
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value: 0.0

962482
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value: 1000.0

962469
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value: 0.0

871869
type: Species
constant: false
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: (R)-Mevalonate

863993
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constant: true
size: NaN
spatial dimensions: 3.0
name: Peroxisome

887208
type: Reaction
notes: SUBSYSTEM: Alanine and Aspartate Metabolism
product: 887256
product: 887244
name: L-alanine transaminase, mitochondrial
reactant: 887220
reactant: 887232
reversible: true
fast: false
kinetic law: 887268

887256
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species: 870911

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species: 870055

870055
type: Species
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Glutamate

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species: 869448

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stoichiometry: 1.0
species: 869460

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type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Alanine

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type: LocalParameter
value: 0.0

887305
type: LocalParameter
value: 0.0

887293
type: LocalParameter
value: 1000.0

887281
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value: -1000.0

914603
type: Reaction
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203380.1 or NM_015256.2 or NM_001995.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
name: fatty-acid--CoA ligase (isolinoleate, C18:2 n-9)
reactant: 914628
product: 914652
reactant: 914640
reversible: true
product: 914664
reactant: 914616
kinetic law: 914688
product: 914676

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species: 865883

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stoichiometry: 1.0
species: 865568

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species: 867480

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: isolinoleic acid (C18:2, n-9)

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species: 867492

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name: isolinoleoyl-CoA (C18:2CoA,n-9)

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species: 865641

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value: 0.0

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value: 0.0

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species: 868361

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initial concentration: NaN
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name: H2O

888817
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fast: false
product: 888865
notes: GENE_ASSOCIATION: NM_000045.2 GENE_LIST: NM_000045.2 SUBSYSTEM: Urea Cycle
kinetic law: 888877
reversible: false
reactant: 888841
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reactant: 888829
name: arginase

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species: 868964

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initial concentration: NaN
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in compartment: 863957
name: Urea

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value: 0.0

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species: 867228

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species: 868072

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name: L-Ornithine

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species: 865593

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name: L-Arginine

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: CDPdiacylglycerol, human hepatocyte

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name: dodecanoate (C12:0)

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initial concentration: NaN
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in compartment: 863957
name: 2-Amino-3-carboxymuconate semialdehyde

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type: Reaction
product: 958183
fast: false
reactant: 958159
reversible: true
product: 958171
name: phosphomevalonate kinase, reversible, peroxisome
notes: GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Biosynthesis
kinetic law: 958195
reactant: 958147

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species: 871628

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has only substance units: false
initial concentration: NaN
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name: ADP

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species: 871652

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in compartment: 863993
name: ATP

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species: 871604

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type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: (R)-5-Diphosphomevalonate

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value: 0.0

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value: 0.0

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value: 1000.0

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value: -1000.0

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species: 871616

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initial concentration: NaN
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in compartment: 863993
name: (R)-5-Phosphomevalonate

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Isocitrate

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type: Reaction
kinetic law: 876334
product: 876322
reactant: 876310
fast: false
reversible: true
name: Glycine exchange

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value: 500.0

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value: 0.0

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value: 1000.0

876346
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value: 0.0

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species: 872363

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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: gly_b

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type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Extrasystem

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species: 864381

864381
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Glycine

882096
type: Reaction
kinetic law: 882145
product: 882133
product: 882121
reactant: 882108
notes: GENE_ASSOCIATION: (NM_000019.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000019.2 NM_000182.3 NM_000183.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: acetyl-CoA C-acetyltransferase, mitochondrial

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value: 0.0

882181
type: LocalParameter
value: 0.0

882169
type: LocalParameter
value: 1000.0

882157
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value: -1000.0

882133
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stoichiometry: 1.0
species: 869643

882121
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stoichiometry: 1.0
species: 869364

869364
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Acetoacetyl-CoA

882108
type: SpeciesReference
stoichiometry: 2.0
species: 869412

869412
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Acetyl-CoA

930269
type: Reaction
name: UTP-glucose-1-phosphate uridylyltransferase
fast: false
reactant: 930293
reactant: 930281
reactant: 930305
product: 930329
product: 930317
kinetic law: 930341
notes: GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
reversible: true

930293
type: SpeciesReference
stoichiometry: 1.0
species: 867216

930281
type: SpeciesReference
stoichiometry: 1.0
species: 866937

866937
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Glucose 1-phosphate

930305
type: SpeciesReference
stoichiometry: 1.0
species: 868988

868988
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: UTP

930329
type: SpeciesReference
stoichiometry: 1.0
species: 868903

868903
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: UDPglucose

930317
type: SpeciesReference
stoichiometry: 1.0
species: 868361

930389
type: LocalParameter
value: 0.0

930377
type: LocalParameter
value: 0.0

930365
type: LocalParameter
value: 1000.0

930353
type: LocalParameter
value: -1000.0

881019
type: Reaction
kinetic law: 881055
product: 881043
reactant: 881031
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 5-Amino-4-oxopentanoate mitochondrial transport

881103
type: LocalParameter
value: 0.0

881091
type: LocalParameter
value: 0.0

881079
type: LocalParameter
value: 1000.0

881067
type: LocalParameter
value: -1000.0

881043
type: SpeciesReference
stoichiometry: 1.0
species: 869339

869339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 5-Amino-4-oxopentanoate

881031
type: SpeciesReference
stoichiometry: 1.0
species: 865242

865242
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Amino-4-oxopentanoate

872411
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: hco3_b

964291
type: Reaction
reactant: 964303
name: L-serine via sodium symport, blood
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_030674.2 or NM_007231.1 or NM_018976.3 or NM_001077484.1) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
product: 964339
kinetic law: 964351
reactant: 964315
product: 964327
reversible: true
fast: false

964303
type: SpeciesReference
stoichiometry: 1.0
species: 864576

864576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Sodium

964339
type: SpeciesReference
stoichiometry: 1.0
species: 868553

868553
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Serine

964399
type: LocalParameter
value: 0.0

964387
type: LocalParameter
value: 0.0

964375
type: LocalParameter
value: 1000.0

964363
type: LocalParameter
value: -1000.0

964315
type: SpeciesReference
stoichiometry: 1.0
species: 864771

864771
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Serine

964327
type: SpeciesReference
stoichiometry: 1.0
species: 867782

867782
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Sodium

945567
type: Reaction
product: 945615
notes: GENE_ASSOCIATION: NM_005957.3 GENE_LIST: NM_005957.3 SUBSYSTEM: Nucleotide Metabolism
reactant: 945591
fast: false
product: 945627
reversible: true
name: methylenetetrahydrofolate reductase (NADPH2)
product: 945603
reactant: 945579
kinetic law: 945639

945615
type: SpeciesReference
stoichiometry: 1.0
species: 867734

867734
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5,10-Methylenetetrahydrofolate

945591
type: SpeciesReference
stoichiometry: 1.0
species: 867818

867818
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Nicotinamide adenine dinucleotide phosphate

945627
type: SpeciesReference
stoichiometry: 1.0
species: 867830

867830
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Nicotinamide adenine dinucleotide phosphate - reduced

945603
type: SpeciesReference
stoichiometry: 2.0
species: 867216

945579
type: SpeciesReference
stoichiometry: 1.0
species: 865279

865279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Methyltetrahydrofolate

945687
type: LocalParameter
value: 0.0

945675
type: LocalParameter
value: 0.0

945663
type: LocalParameter
value: 1000.0

945651
type: LocalParameter
value: -1000.0

868541
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Sarcosine

868048
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecenoyl-CoA (C18:1CoA, n-9)

870263
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: heptadecanoyl carnitine (C17:0Crn)

924003
type: Reaction
name: Beta oxidation of odd chain fatty acid
reversible: false
product: 924112
reactant: 924027
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2)) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
fast: false
product: 924076
kinetic law: 924136
reactant: 924015
product: 924088
product: 924124
reactant: 924039
reactant: 924064
product: 924100
reactant: 924051

924112
type: SpeciesReference
stoichiometry: 1.0
species: 870238

870238
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: heptanoyl-CoA (C7:0CoA)

924027
type: SpeciesReference
stoichiometry: 1.0
species: 869945

869945
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: FAD

924076
type: SpeciesReference
stoichiometry: 1.0
species: 869412

924184
type: LocalParameter
value: 500.0

924172
type: LocalParameter
value: 0.0

924160
type: LocalParameter
value: 1000.0

924148
type: LocalParameter
value: 0.0

924015
type: SpeciesReference
stoichiometry: 1.0
species: 869643

924088
type: SpeciesReference
stoichiometry: 1.0
species: 869957

869957
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: FADH2

924124
type: SpeciesReference
stoichiometry: 1.0
species: 870461

870461
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Nicotinamide adenine dinucleotide - reduced

924039
type: SpeciesReference
stoichiometry: 1.0
species: 870152

924064
type: SpeciesReference
stoichiometry: 1.0
species: 870513

870513
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: nonanoyl-CoA (C9:0CoA)

924100
type: SpeciesReference
stoichiometry: 1.0
species: 870140

924051
type: SpeciesReference
stoichiometry: 1.0
species: 870448

870448
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Nicotinamide adenine dinucleotide

865907
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Carnitine

870935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Sulfite

864479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: heptadecanoate (C17:0)

865038
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Dehydrosphinganine

865787
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Choline phosphate

871190
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 4,4-dimethylzymosterol

870335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Leucine

944290
type: Reaction
kinetic law: 944326
product: 944314
reactant: 944302
notes: GENE_ASSOCIATION: NM_002435.1 GENE_LIST: NM_002435.1 SUBSYSTEM: Fructose and Mannose Metabolism
fast: false
reversible: true
name: mannose-6-phosphate isomerase

944374
type: LocalParameter
value: 0.0

944362
type: LocalParameter
value: 0.0

944350
type: LocalParameter
value: 1000.0

944338
type: LocalParameter
value: -1000.0

944314
type: SpeciesReference
stoichiometry: 1.0
species: 866756

866756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Fructose 6-phosphate

944302
type: SpeciesReference
stoichiometry: 1.0
species: 867662

867662
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Mannose 6-phosphate

900599
type: Reaction
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
fast: false
name: carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
product: 900647
kinetic law: 900659
reactant: 900611
reactant: 900623
product: 900635
reversible: true

900647
type: SpeciesReference
stoichiometry: 1.0
species: 870659

870659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecenoyl carnitine (C18:1Crn, n9)

900707
type: LocalParameter
value: 0.0

900695
type: LocalParameter
value: 0.0

900683
type: LocalParameter
value: 1000.0

900671
type: LocalParameter
value: -1000.0

900611
type: SpeciesReference
stoichiometry: 1.0
species: 869655

900623
type: SpeciesReference
stoichiometry: 1.0
species: 870647

870647
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecenoyl-CoA (C18:1CoA, n-9)

900635
type: SpeciesReference
stoichiometry: 1.0
species: 869643

909696
type: Reaction
product: 909780
reversible: false
kinetic law: 909792
reactant: 909744
product: 909768
reactant: 909720
notes: GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis
fast: false
product: 909756
reactant: 909732
reactant: 909708
name: fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)

909780
type: SpeciesReference
stoichiometry: 1.0
species: 867794

867794
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Nicotinamide adenine dinucleotide

909840
type: LocalParameter
value: 500.0

909828
type: LocalParameter
value: 0.0

909816
type: LocalParameter
value: 1000.0

909804
type: LocalParameter
value: 0.0

909744
type: SpeciesReference
stoichiometry: 1.0
species: 867854

867854
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: O2

909768
type: SpeciesReference
stoichiometry: 2.0
species: 867228

909720
type: SpeciesReference
stoichiometry: 1.0
species: 867216

909756
type: SpeciesReference
stoichiometry: 1.0
species: 866707

866707
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)

909732
type: SpeciesReference
stoichiometry: 1.0
species: 867806

867806
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Nicotinamide adenine dinucleotide - reduced

909708
type: SpeciesReference
stoichiometry: 1.0
species: 866635

866635
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatrienoyl-CoA (C20:3CoA, n-6)

866064
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosanoate (n-C22:0)

958882
type: Reaction
reversible: false
reactant: 958906
product: 958930
reactant: 958894
fast: false
product: 958918
name: inorganic pyrophosphatase
notes: GENE_ASSOCIATION: (NM_176869.2 or NM_006903.4 or NM_001034191.1 or NM_176866.2 or NM_176867.3) GENE_LIST: NM_001034191.1 NM_006903.4 NM_176866.2 NM_176867.3 NM_176869.2 SUBSYSTEM: Oxidative Phosphorylation
kinetic law: 958942

958906
type: SpeciesReference
stoichiometry: 1.0
species: 870863

870863
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Diphosphate

958930
type: SpeciesReference
stoichiometry: 2.0
species: 870803

958894
type: SpeciesReference
stoichiometry: 1.0
species: 870152

958918
type: SpeciesReference
stoichiometry: 1.0
species: 870140

958990
type: LocalParameter
value: 500.0

958978
type: LocalParameter
value: 0.0

958966
type: LocalParameter
value: 1000.0

958954
type: LocalParameter
value: 0.0

908348
type: Reaction
kinetic law: 908384
product: 908372
reactant: 908360
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: dodecanoate (C12:0) mammalian cell transport

908433
type: LocalParameter
value: 0.0

908421
type: LocalParameter
value: 0.0

908409
type: LocalParameter
value: 1000.0

908396
type: LocalParameter
value: -1000.0

908372
type: SpeciesReference
stoichiometry: 1.0
species: 864200

908360
type: SpeciesReference
stoichiometry: 1.0
species: 866149

866149
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dodecanoate (C12:0)

877569
type: Reaction
kinetic law: 877605
product: 877593
reactant: 877581
fast: false
reversible: true
name: L-Lysine exchange

877653
type: LocalParameter
value: -0.007906395

877641
type: LocalParameter
value: 0.0

877629
type: LocalParameter
value: 0.0

877617
type: LocalParameter
value: -0.01581279

877593
type: SpeciesReference
stoichiometry: 1.0
species: 872520

872520
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: lys_L_b

877581
type: SpeciesReference
stoichiometry: 1.0
species: 864539

864539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Lysine

868927
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: UMP

960187
type: Reaction
product: 960247
name: phosphoribosylglycinamide synthetase
reactant: 960199
reactant: 960211
reversible: false
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
product: 960259
kinetic law: 960283
product: 960235
reactant: 960223
product: 960271
fast: false

960247
type: SpeciesReference
stoichiometry: 1.0
species: 866999

866999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N1-(5-Phospho-D-ribosyl)glycinamide

960199
type: SpeciesReference
stoichiometry: 1.0
species: 865641

960211
type: SpeciesReference
stoichiometry: 1.0
species: 867095

867095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Glycine

960259
type: SpeciesReference
stoichiometry: 1.0
species: 867216

960331
type: LocalParameter
value: 500.0

960319
type: LocalParameter
value: 0.0

960307
type: LocalParameter
value: 1000.0

960295
type: LocalParameter
value: 0.0

960235
type: SpeciesReference
stoichiometry: 1.0
species: 865460

865460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ADP

960223
type: SpeciesReference
stoichiometry: 1.0
species: 868409

868409
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Phospho-beta-D-ribosylamine

960271
type: SpeciesReference
stoichiometry: 1.0
species: 868265

868265
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Phosphate

964037
type: Reaction
kinetic law: 964085
product: 964073
product: 964061
reactant: 964049
notes: GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine and Serine Metabolism
fast: false
reversible: false
name: L-serine deaminase

964134
type: LocalParameter
value: 500.0

964122
type: LocalParameter
value: 0.0

964110
type: LocalParameter
value: 1000.0

964097
type: LocalParameter
value: 0.0

964073
type: SpeciesReference
stoichiometry: 1.0
species: 868493

964061
type: SpeciesReference
stoichiometry: 1.0
species: 867842

867842
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Ammonium

964049
type: SpeciesReference
stoichiometry: 1.0
species: 868553

937151
type: Reaction
name: HCO3 equilibration reaction, mitochondrial
reversible: true
kinetic law: 937211
product: 937199
fast: false
reactant: 937175
reactant: 937163
product: 937187
notes: GENE_ASSOCIATION: (NM_001739.1 or NM_007220.2) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Central Metabolism

937260
type: LocalParameter
value: 0.0

937248
type: LocalParameter
value: 0.0

937236
type: LocalParameter
value: 1000.0

937223
type: LocalParameter
value: -1000.0

937199
type: SpeciesReference
stoichiometry: 1.0
species: 870176

870176
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Bicarbonate

937175
type: SpeciesReference
stoichiometry: 1.0
species: 870152

937163
type: SpeciesReference
stoichiometry: 1.0
species: 869631

869631
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: CO2

937187
type: SpeciesReference
stoichiometry: 1.0
species: 870140

870623
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecatrienoyl carnitine (C18:3Crn, n3)

934277
type: Reaction
kinetic law: 934349
name: glycerol kinase
notes: GENE_ASSOCIATION: (NM_000167.3 or NM_203391.1) GENE_LIST: NM_000167.3 NM_203391.1 SUBSYSTEM: Glycerophospholipid Metabolism
product: 934337
product: 934313
reactant: 934289
product: 934325
reversible: false
fast: false
reactant: 934301

934397
type: LocalParameter
value: 500.0

934385
type: LocalParameter
value: 0.0

934373
type: LocalParameter
value: 1000.0

934361
type: LocalParameter
value: 0.0

934337
type: SpeciesReference
stoichiometry: 1.0
species: 867216

934313
type: SpeciesReference
stoichiometry: 1.0
species: 865460

934289
type: SpeciesReference
stoichiometry: 1.0
species: 865641

934325
type: SpeciesReference
stoichiometry: 1.0
species: 867131

867131
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: sn-Glycerol 3-phosphate

934301
type: SpeciesReference
stoichiometry: 1.0
species: 867119

867119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Glycerol

865025
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-(4-Hydroxyphenyl)pyruvate

953415
type: Reaction
reactant: 953439
kinetic law: 953487
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
product: 953463
fast: false
reversible: false
product: 953451
notes: SUBSYSTEM: Bile Acid Biosynthesis
reactant: 953427
product: 953475

953439
type: SpeciesReference
stoichiometry: 1.0
species: 871154

871154
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane

953535
type: LocalParameter
value: 500.0

953523
type: LocalParameter
value: 0.0

953511
type: LocalParameter
value: 1000.0

953499
type: LocalParameter
value: 0.0

953463
type: SpeciesReference
stoichiometry: 1.0
species: 870461

953451
type: SpeciesReference
stoichiometry: 1.0
species: 870140

953427
type: SpeciesReference
stoichiometry: 1.0
species: 870448

953475
type: SpeciesReference
stoichiometry: 1.0
species: 871070

871070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al

865774
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Choloyl-CoA

959510
type: Reaction
product: 959596
product: 959571
reactant: 959534
product: 959583
product: 959559
fast: false
kinetic law: 959608
notes: GENE_ASSOCIATION: (NM_000282.2 and NM_000532.2) GENE_LIST: NM_000282.2 NM_000532.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reversible: true
reactant: 959522
name: Propionyl-CoA carboxylase, mitochondrial
reactant: 959547

959596
type: SpeciesReference
stoichiometry: 1.0
species: 870803

959571
type: SpeciesReference
stoichiometry: 1.0
species: 870140

959534
type: SpeciesReference
stoichiometry: 1.0
species: 870176

959583
type: SpeciesReference
stoichiometry: 1.0
species: 870434

870434
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-Methylmalonyl-CoA

959559
type: SpeciesReference
stoichiometry: 1.0
species: 869436

959656
type: LocalParameter
value: 0.0

959644
type: LocalParameter
value: 0.0

959632
type: LocalParameter
value: 1000.0

959620
type: LocalParameter
value: -1000.0

959522
type: SpeciesReference
stoichiometry: 1.0
species: 869509

959547
type: SpeciesReference
stoichiometry: 1.0
species: 870851

870851
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Propanoyl-CoA (C3:0CoA)

897816
type: Reaction
name: eicosenoyl carnitine transport (C20:1Crn, n9)
reactant: 897828
product: 897864
kinetic law: 897876
product: 897852
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
fast: false
reactant: 897840

897828
type: SpeciesReference
stoichiometry: 1.0
species: 866598

866598
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosenoyl carnitine (C20:1Crn, n9)

897864
type: SpeciesReference
stoichiometry: 1.0
species: 869836

869836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosenoyl carnitine (C20:1Crn, n9)

897924
type: LocalParameter
value: 0.0

897912
type: LocalParameter
value: 0.0

897900
type: LocalParameter
value: 1000.0

897888
type: LocalParameter
value: -1000.0

897852
type: SpeciesReference
stoichiometry: 1.0
species: 865907

897840
type: SpeciesReference
stoichiometry: 1.0
species: 869655

867976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ocosatetraenoate (C22:4, n-6)

867456
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: IDP

965579
type: Reaction
product: 965639
kinetic law: 965663
name: Squalene synthase, endoplasmic reticulum
reversible: false
product: 965627
fast: false
reactant: 965615
reactant: 965603
reactant: 965591
product: 965651
notes: GENE_ASSOCIATION: NM_004462.3 GENE_LIST: NM_004462.3 SUBSYSTEM: Cholesterol Biosynthesis

965639
type: SpeciesReference
stoichiometry: 2.0
species: 871505

871505
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Diphosphate

965711
type: LocalParameter
value: 500.0

965699
type: LocalParameter
value: 0.0

965687
type: LocalParameter
value: 1000.0

965675
type: LocalParameter
value: 0.0

965627
type: SpeciesReference
stoichiometry: 1.0
species: 871457

871457
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Nicotinamide adenine dinucleotide phosphate

965615
type: SpeciesReference
stoichiometry: 1.0
species: 871469

871469
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Nicotinamide adenine dinucleotide phosphate - reduced

965603
type: SpeciesReference
stoichiometry: 1.0
species: 871385

871385
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: H+

965591
type: SpeciesReference
stoichiometry: 2.0
species: 871349

871349
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Farnesyl diphosphate

965651
type: SpeciesReference
stoichiometry: 1.0
species: 871517

871517
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Squalene

868145
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Pantetheine 4'-phosphate

870395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Methylmalonate

907638
type: Reaction
notes: GENE_ASSOCIATION: (NM_003676.2 or NM_206918.1 or NM_144780.1) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Sphingolipid Metabolism
reactant: 907650
product: 907698
reactant: 907662
fast: false
name: Dihydroceramide desaturase, hepatocyte
product: 907722
reversible: false
product: 907710
kinetic law: 907734
reactant: 907674
reactant: 907686

907650
type: SpeciesReference
stoichiometry: 0.001
species: 866039

866039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dihydroceramide, hepatocyte

907698
type: SpeciesReference
stoichiometry: 0.001
species: 865737

865737
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ceramide, hepatocyte

907662
type: SpeciesReference
stoichiometry: 1.0
species: 867216

907722
type: SpeciesReference
stoichiometry: 1.0
species: 867818

907710
type: SpeciesReference
stoichiometry: 2.0
species: 867228

907782
type: LocalParameter
value: 500.0

907770
type: LocalParameter
value: 0.0

907758
type: LocalParameter
value: 1000.0

907746
type: LocalParameter
value: 0.0

907674
type: SpeciesReference
stoichiometry: 1.0
species: 867830

907686
type: SpeciesReference
stoichiometry: 1.0
species: 867854

942869
type: Reaction
kinetic law: 942905
product: 942893
reactant: 942881
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_001126106.1 or NM_182728.1 or NM_003982.3 or NM_001126105.1 or NM_012244.2 or NM_003627.4) GENE_LIST: NM_001126105.1 NM_001126106.1 NM_003486.5 NM_003627.4 NM_003982.3 NM_012244.2 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-leucine transport via diffusion, blood

942953
type: LocalParameter
value: 0.0

942941
type: LocalParameter
value: 0.0

942929
type: LocalParameter
value: 1000.0

942917
type: LocalParameter
value: -1000.0

942893
type: SpeciesReference
stoichiometry: 1.0
species: 867589

867589
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Leucine

942881
type: SpeciesReference
stoichiometry: 1.0
species: 864527

864527
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Leucine

923049
type: Reaction
reversible: false
reactant: 923061
kinetic law: 923169
reactant: 923085
product: 923145
product: 923121
name: Beta oxidation of fatty acid
product: 923157
product: 923133
reactant: 923073
reactant: 923097
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_000017.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2)) GENE_LIST: NM_000016.2 NM_000017.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
fast: false
reactant: 923109

923061
type: SpeciesReference
stoichiometry: 1.0
species: 869535

869535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Butanoyl-CoA (C4:0CoA)

923217
type: LocalParameter
value: 500.0

923205
type: LocalParameter
value: 0.0

923193
type: LocalParameter
value: 1000.0

923181
type: LocalParameter
value: 0.0

923085
type: SpeciesReference
stoichiometry: 1.0
species: 869945

923145
type: SpeciesReference
stoichiometry: 1.0
species: 870140

923121
type: SpeciesReference
stoichiometry: 2.0
species: 869412

923157
type: SpeciesReference
stoichiometry: 1.0
species: 870461

923133
type: SpeciesReference
stoichiometry: 1.0
species: 869957

923073
type: SpeciesReference
stoichiometry: 1.0
species: 869643

923097
type: SpeciesReference
stoichiometry: 1.0
species: 870152

923109
type: SpeciesReference
stoichiometry: 1.0
species: 870448

885137
type: Reaction
kinetic law: 885185
product: 885173
product: 885161
reactant: 885149
notes: GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Metabolism
fast: false
reversible: true
name: adenylosuccinate lyase

885233
type: LocalParameter
value: 0.0

885221
type: LocalParameter
value: 0.0

885209
type: LocalParameter
value: 1000.0

885197
type: LocalParameter
value: -1000.0

885173
type: SpeciesReference
stoichiometry: 1.0
species: 866924

866924
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Fumarate

885161
type: SpeciesReference
stoichiometry: 1.0
species: 865496

865496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

885149
type: SpeciesReference
stoichiometry: 1.0
species: 864953

864953
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

871433
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Nicotinamide adenine dinucleotide

864869
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Valine

937392
type: Reaction
kinetic law: 937428
product: 937416
reactant: 937404
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecanoate (C16:0) transport

937476
type: LocalParameter
value: 0.0

937464
type: LocalParameter
value: 0.0

937452
type: LocalParameter
value: 1000.0

937440
type: LocalParameter
value: -1000.0

937416
type: SpeciesReference
stoichiometry: 1.0
species: 864442

864442
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: hexadecanoate (n-C16:0)

937404
type: SpeciesReference
stoichiometry: 1.0
species: 867276

867276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: hexadecanoate (n-C16:0)

871929
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: propionyl-carnitine

867071
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Glutamate 5-semialdehyde

949283
type: Reaction
reactant: 949307
product: 949331
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
fast: false
product: 949319
reversible: true
notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Purine and Pyrimidine Metabolism
reactant: 949295
kinetic law: 949343

949307
type: SpeciesReference
stoichiometry: 1.0
species: 869559

869559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: CDP

949331
type: SpeciesReference
stoichiometry: 1.0
species: 869667

869667
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: CTP

949319
type: SpeciesReference
stoichiometry: 1.0
species: 869436

949295
type: SpeciesReference
stoichiometry: 1.0
species: 869509

949391
type: LocalParameter
value: 0.0

949379
type: LocalParameter
value: 0.0

949367
type: LocalParameter
value: 1000.0

949355
type: LocalParameter
value: -1000.0

959122
type: Reaction
name: phosphopantothenoylcysteine decarboxylase
fast: false
product: 959158
reversible: false
kinetic law: 959183
reactant: 959134
notes: GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
reactant: 959146
product: 959170

959158
type: SpeciesReference
stoichiometry: 1.0
species: 865871

865871
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: CO2

959232
type: LocalParameter
value: 500.0

959219
type: LocalParameter
value: 0.0

959207
type: LocalParameter
value: 1000.0

959195
type: LocalParameter
value: 0.0

959134
type: SpeciesReference
stoichiometry: 1.0
species: 865218

865218
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

959146
type: SpeciesReference
stoichiometry: 1.0
species: 867216

959170
type: SpeciesReference
stoichiometry: 1.0
species: 868145

865254
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Formiminotetrahydrofolate

868505
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: alpha-D-Ribose 5-phosphate

949763
type: Reaction
fast: false
name: nucleoside-diphosphate kinase (ATP:dCDP)
product: 949800
reversible: true
reactant: 949775
kinetic law: 949824
reactant: 949787
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018138.1) or (NM_001018139.1 and NM_198175.1) or NM_197972.1 or NM_013330.3 or NM_005793.3 or NM_002513.2 or (NM_000269.2 and NM_001018137.1) or (NM_001018137.1 and NM_198175.1) or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or (NM_000269.2 and NM_001018139.1) or (NM_002512.2 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotides
product: 949812

949800
type: SpeciesReference
stoichiometry: 1.0
species: 865460

949775
type: SpeciesReference
stoichiometry: 1.0
species: 865641

949873
type: LocalParameter
value: 0.0

949860
type: LocalParameter
value: 0.0

949848
type: LocalParameter
value: 1000.0

949836
type: LocalParameter
value: -1000.0

949787
type: SpeciesReference
stoichiometry: 1.0
species: 866027

866027
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dCDP

949812
type: SpeciesReference
stoichiometry: 1.0
species: 866125

866125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dCTP

870551
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Oxaloacetate

963242
type: Reaction
reactant: 963278
kinetic law: 963338
fast: false
product: 963302
reactant: 963266
product: 963314
reversible: true
notes: GENE_ASSOCIATION: (NM_016002.2 or NM_005763.2) GENE_LIST: NM_005763.2 NM_016002.2 SUBSYSTEM: Lysine Degradation
name: saccharopine dehydrogenase (NAD, L-glutamate-forming), mitochondrial
product: 963326
product: 963290
reactant: 963254

963278
type: SpeciesReference
stoichiometry: 1.0
species: 870448

963387
type: LocalParameter
value: 0.0

963375
type: LocalParameter
value: 0.0

963363
type: LocalParameter
value: 1000.0

963351
type: LocalParameter
value: -1000.0

963302
type: SpeciesReference
stoichiometry: 1.0
species: 870055

963266
type: SpeciesReference
stoichiometry: 1.0
species: 870152

963314
type: SpeciesReference
stoichiometry: 1.0
species: 870140

963326
type: SpeciesReference
stoichiometry: 1.0
species: 870461

963290
type: SpeciesReference
stoichiometry: 1.0
species: 869485

869485
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-2-Aminoadipate 6-semialdehyde

963254
type: SpeciesReference
stoichiometry: 1.0
species: 869352

872864
type: Reaction
reactant: 873299
reactant: 873371
reactant: 873140
reactant: 873239
reactant: 873311
reactant: 873008
reactant: 872960
reactant: 872924
reactant: 873080
reactant: 873190
reactant: 873347
reactant: 873275
reactant: 873056
reactant: 873116
product: 873383
reactant: 873263
reversible: false
reactant: 873227
reactant: 872912
reactant: 873032
product: 873395
reactant: 873068
reactant: 873178
reactant: 872948
reactant: 872888
reactant: 873165
reactant: 873335
reactant: 873153
reactant: 872996
reactant: 873044
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reactant: 873215
reactant: 872900
reactant: 873202
reactant: 873020
reactant: 873128
reactant: 872972
product: 873407
reactant: 872936
reactant: 873092
product: 873419
reactant: 873251
reactant: 873359
reactant: 872876
kinetic law: 873431
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reactant: 872984
reactant: 873104

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species: 868577

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867336
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initial concentration: NaN
initial amount: NaN
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species: 868229

868229
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initial concentration: NaN
initial amount: NaN
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species: 868770

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initial concentration: NaN
initial amount: NaN
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species: 865991

865991
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initial concentration: NaN
initial amount: NaN
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species: 865811

865811
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initial concentration: NaN
initial amount: NaN
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species: 865629

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initial concentration: NaN
initial amount: NaN
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species: 867059

867059
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has only substance units: false
initial concentration: NaN
initial amount: NaN
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species: 867686

867686
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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species: 868879

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initial concentration: NaN
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species: 868445

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initial concentration: NaN
initial amount: NaN
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species: 866768

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initial concentration: NaN
initial amount: NaN
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species: 867204

867204
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initial concentration: NaN
initial amount: NaN
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species: 865460

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species: 868421

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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Proline

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species: 868205

868205
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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species: 865617

865617
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Asparagine

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species: 866197

866197
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dGTP

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species: 867216

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species: 867047

867047
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Glutamine

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species: 867614

867614
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Lysine

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species: 865799

865799
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Cholesterol ester, hepatocyte

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species: 865532

865532
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Alanine

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species: 867589

873335
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species: 868830

868830
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Tryptophan

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species: 867468

867468
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Isoleucine

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species: 865931

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Cysteine

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species: 866380

866380
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: dTTP

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species: 868553

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species: 868157

868157
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Phosphatidylcholine, human hepatocyte

872900
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species: 865593

873202
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species: 868133

868133
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: Phosphatidate, Hepatocyte

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species: 866125

873128
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species: 867228

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species: 865847

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: cardiolipin, hepatocyte

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species: 868265

872936
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species: 865641

873092
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species: 867095

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species: 868361

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species: 868277

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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 863957
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species: 868988

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species: 864893

864893
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 1,2-Diacylglycerol, human hepatocyte

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873455
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value: 1000.0

873443
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value: 0.0347

873323
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species: 868818

868818
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: triglyceride, hepatocyte

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species: 865919

865919
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constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
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species: 867143

867143
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: glycogen

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kinetic law: 937524
product: 937512
reactant: 937500
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecenoate (C16:1, n-7) transport

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value: 1000.0

937537
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species: 864454

864454
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: hexadecenoate (C16:1, n-7)

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species: 867288

867288
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: hexadecenoate (C16:1, n-7)

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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: H2O

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product: 905522
kinetic law: 905534
reversible: true
reactant: 905498
product: 905510
notes: SUBSYSTEM: Cysteine Metabolism
reactant: 905486
fast: false
name: Glutathione:cystine oxidoreductase

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species: 867180

867180
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Oxidized glutathione

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value: 0.0

905558
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value: 1000.0

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species: 867192

867192
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Reduced glutathione

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species: 865931

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species: 865943

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Cystine

886138
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fast: false
kinetic law: 886222
product: 886186
reactant: 886174
product: 886210
reversible: false
reactant: 886162
reactant: 886150
name: alphaketobutyrate dehydrogenase (mitochondrial)
product: 886198
notes: SUBSYSTEM: Cysteine Metabolism

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886259
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886247
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value: 1000.0

886235
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species: 869631

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species: 870448

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species: 870851

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species: 869643

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species: 869170

869170
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 2-Oxobutanoate

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species: 870461

911318
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product: 911366
product: 911354
kinetic law: 911390
notes: GENE_ASSOCIATION: (NM_025233.4 or NM_001042530.1 or NM_001042531.1 or NM_001042529.1 or NM_001042532.1) GENE_LIST: NM_001042529.1 NM_001042530.1 NM_001042531.1 NM_001042532.1 NM_025233.4 SUBSYSTEM: CoA Biosynthesis
reactant: 911342
reactant: 911330
reversible: false
fast: false
name: dephospho-CoA kinase
product: 911378

911366
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stoichiometry: 1.0
species: 865883

911354
type: SpeciesReference
stoichiometry: 1.0
species: 865460

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value: 500.0

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value: 0.0

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value: 1000.0

911402
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value: 0.0

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species: 866271

866271
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Dephospho-CoA

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species: 865641

911378
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stoichiometry: 1.0
species: 867216

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kinetic law: 969824
product: 969812
reactant: 969800
notes: GENE_ASSOCIATION: (NM_000403.3 or NM_001008216.1 or NM_001127621.1) GENE_LIST: NM_000403.3 NM_001008216.1 NM_001127621.1 SUBSYSTEM: Galactose Metabolism
fast: false
reversible: true
name: UDPglucose 4-epimerase

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value: 0.0

969860
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value: 0.0

969848
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value: 1000.0

969836
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value: -1000.0

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species: 868915

868915
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: UDPgalactose

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species: 868903

871361
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: D-Glucose 6-phosphate

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fast: false
name: cystathionine g-lyase
product: 905764
product: 905776
reactant: 905740
reversible: false
kinetic law: 905800
product: 905788
notes: GENE_ASSOCIATION: (NM_153742.3 or NM_001902.4) GENE_LIST: NM_001902.4 NM_153742.3 SUBSYSTEM: Serine metabolism
reactant: 905752

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species: 864989

864989
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Oxobutanoate

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species: 865931

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species: 865955

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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Cystathionine

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value: 0.0

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value: 1000.0

905812
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species: 867842

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stoichiometry: 1.0
species: 867228

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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: nh4_b

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fast: false
reactant: 904882
reversible: false
kinetic law: 904943
product: 904894
product: 904931
product: 904919
notes: GENE_ASSOCIATION: NM_001905.1 GENE_LIST: NM_001905.1 SUBSYSTEM: Nucleotides
reactant: 904857
reactant: 904869
product: 904907
name: CTP synthase (NH3)

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species: 868988

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value: 500.0

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value: 0.0

904967
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value: 1000.0

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species: 865460

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species: 868265

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species: 867216

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species: 865641

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species: 867842

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stoichiometry: 1.0
species: 865919

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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: hdcea7_b

957387
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reactant: 957411
fast: false
reversible: true
reactant: 957399
product: 957423
notes: GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
name: phosphate transport in/out via proton symporter
kinetic law: 957448
product: 957436

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species: 864711

864711
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Phosphate

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species: 864405

864405
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: H+

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species: 867216

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957484
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value: 0.0

957472
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value: 1000.0

957460
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957436
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stoichiometry: 1.0
species: 868265

868565
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Sulfite

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kinetic law: 894687
product: 894675
reactant: 894663
notes: GENE_ASSOCIATION: (NM_020428.2 or NM_001114106.1 or NM_080546.2 or NM_152369.2 or NM_025257.1) GENE_LIST: NM_001114106.1 NM_020428.2 NM_025257.1 NM_080546.2 NM_152369.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Choline transport, blood

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value: 0.0

894723
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value: 0.0

894711
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value: 1000.0

894699
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value: -1000.0

894675
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stoichiometry: 1.0
species: 865761

865761
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Choline

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species: 864114

864114
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Choline

944482
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name: methylcrotonoyl-CoA carboxylase, mitochondrial
product: 944567
reactant: 944507
product: 944531
reactant: 944519
reactant: 944495
notes: GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
kinetic law: 944579
product: 944543
reversible: false
product: 944555
fast: false

944567
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stoichiometry: 1.0
species: 870803

944507
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stoichiometry: 1.0
species: 869509

944531
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stoichiometry: 1.0
species: 869266

869266
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3-Methylglutaconyl-CoA

944519
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stoichiometry: 1.0
species: 870176

944495
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stoichiometry: 1.0
species: 869254

869254
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3-Methylbut-2-enoyl-CoA

944627
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value: 500.0

944615
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value: 0.0

944603
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value: 1000.0

944591
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944543
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stoichiometry: 1.0
species: 869436

944555
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stoichiometry: 1.0
species: 870140

866307
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoyl-CoA (C22:5CoA, n-3)

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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: orn_L_b

890341
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reactant: 890353
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Cysteine Metabolism
name: aspartate transaminase
kinetic law: 890401
fast: false
product: 890377
reactant: 890365
reversible: true
product: 890389

890353
type: SpeciesReference
stoichiometry: 1.0
species: 865520

865520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Oxoglutarate

890449
type: LocalParameter
value: 0.0

890437
type: LocalParameter
value: 0.0

890425
type: LocalParameter
value: 1000.0

890413
type: LocalParameter
value: -1000.0

890377
type: SpeciesReference
stoichiometry: 1.0
species: 867059

890365
type: SpeciesReference
stoichiometry: 1.0
species: 865931

890389
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stoichiometry: 1.0
species: 867674

867674
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Mercaptopyruvate

872533
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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: man_b

935833
type: Reaction
kinetic law: 935870
product: 935858
reactant: 935846
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: hydrogen peroxide mitochondrial transport

935918
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value: 0.0

935906
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value: 0.0

935894
type: LocalParameter
value: 1000.0

935882
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value: -1000.0

935858
type: SpeciesReference
stoichiometry: 1.0
species: 870164

870164
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Hydrogen peroxide

935846
type: SpeciesReference
stoichiometry: 1.0
species: 867240

867240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Hydrogen peroxide

892285
type: Reaction
product: 892370
product: 892345
reactant: 892333
kinetic law: 892382
product: 892358
fast: false
notes: GENE_ASSOCIATION: (NM_001017369.1 or NM_006745.3) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 892297
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol), endoplasmic reticulum
reactant: 892309
reactant: 892321
reversible: false

892370
type: SpeciesReference
stoichiometry: 3.0
species: 871457

892345
type: SpeciesReference
stoichiometry: 1.0
species: 871203

892333
type: SpeciesReference
stoichiometry: 3.0
species: 871481

871481
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: O2

892430
type: LocalParameter
value: 500.0

892418
type: LocalParameter
value: 0.0

892406
type: LocalParameter
value: 1000.0

892394
type: LocalParameter
value: 0.0

892358
type: SpeciesReference
stoichiometry: 4.0
species: 871397

892297
type: SpeciesReference
stoichiometry: 1.0
species: 871190

892309
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stoichiometry: 2.0
species: 871385

892321
type: SpeciesReference
stoichiometry: 3.0
species: 871469

864601
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: O2

870359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Malate

864188
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: docosapentaenoate (C22:5, n-6)

868109
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ocosatetraenoyl-CoA (C22:4CoA, n-6)

869909
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosatrienoyl carnitine (C20:3Crn, n9)

893434
type: Reaction
kinetic law: 893482
product: 893470
reactant: 893458
reactant: 893446
notes: GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
fast: false
reversible: false
name: cysteine dioxygenase

893531
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value: 500.0

893518
type: LocalParameter
value: 0.0

893506
type: LocalParameter
value: 1000.0

893494
type: LocalParameter
value: 0.0

893470
type: SpeciesReference
stoichiometry: 1.0
species: 865122

865122
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Sulfino-L-alanine

893458
type: SpeciesReference
stoichiometry: 1.0
species: 867854

893446
type: SpeciesReference
stoichiometry: 1.0
species: 865931

870827
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Palmitoylcarnitine (C16:0Crn)

936545
type: Reaction
kinetic law: 936618
product: 936582
product: 936594
reactant: 936557
reactant: 936569
fast: false
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
reversible: true
product: 936606
notes: GENE_ASSOCIATION: (NM_001037811.2 or NM_004493.2) GENE_LIST: NM_001037811.2 NM_004493.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

936667
type: LocalParameter
value: 0.0

936655
type: LocalParameter
value: 0.0

936642
type: LocalParameter
value: 1000.0

936630
type: LocalParameter
value: -1000.0

936582
type: SpeciesReference
stoichiometry: 1.0
species: 869121

869121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 2-Methyl-3-acetoacetyl-CoA

936594
type: SpeciesReference
stoichiometry: 1.0
species: 870140

936557
type: SpeciesReference
stoichiometry: 1.0
species: 869230

869230
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-3-Hydroxy-2-methylbutyryl-CoA

936569
type: SpeciesReference
stoichiometry: 1.0
species: 870448

936606
type: SpeciesReference
stoichiometry: 1.0
species: 870461

966386
type: Reaction
reactant: 966398
kinetic law: 966446
reactant: 966410
product: 966434
reversible: true
fast: false
product: 966422
name: succinate dehydrogenase cytochrome b
notes: GENE_ASSOCIATION: (NM_001035512.1 or NM_001035513.1 or NM_001035511.1) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 SUBSYSTEM: Oxidative Phosphorylation

966398
type: SpeciesReference
stoichiometry: 1.0
species: 869957

966494
type: LocalParameter
value: 0.0

966482
type: LocalParameter
value: 0.0

966470
type: LocalParameter
value: 1000.0

966458
type: LocalParameter
value: -1000.0

966410
type: SpeciesReference
stoichiometry: 1.0
species: 871130

871130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ubiquinone-10

966434
type: SpeciesReference
stoichiometry: 1.0
species: 870923

870923
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ubiquinol-10

966422
type: SpeciesReference
stoichiometry: 1.0
species: 869945

958388
type: Reaction
reactant: 958412
product: 958424
reactant: 958400
kinetic law: 958448
reversible: false
name: Pantothenate sodium symporter, blood
product: 958436
fast: false
notes: GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular

958412
type: SpeciesReference
stoichiometry: 1.0
species: 864723

864723
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: (R)-Pantothenate

958424
type: SpeciesReference
stoichiometry: 1.0
species: 867782

958400
type: SpeciesReference
stoichiometry: 1.0
species: 864576

958496
type: LocalParameter
value: 500.0

958484
type: LocalParameter
value: 0.0

958472
type: LocalParameter
value: 1000.0

958460
type: LocalParameter
value: 0.0

958436
type: SpeciesReference
stoichiometry: 1.0
species: 868313

868313
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (R)-Pantothenate

866888
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

934157
type: Reaction
product: 934181
reactant: 934169
product: 934205
notes: GENE_ASSOCIATION: ((NM_001079855.1 and NM_002103.3) or (NM_004130.2 and NM_021957.2) or (NM_004130.2 and NM_002103.3) or (NM_003918.1 and NM_021957.2) or (NM_003918.1 and NM_002103.3) or (NM_001079855.1 and NM_021957.2)) GENE_LIST: NM_001079855.1 NM_002103.3 NM_003918.1 NM_004130.2 NM_021957.2 SUBSYSTEM: Glycogen Metabolism
reversible: false
kinetic law: 934217
product: 934193
name: glycogen synthase (UDPGlc)
fast: false

934181
type: SpeciesReference
stoichiometry: 1.0
species: 867143

934169
type: SpeciesReference
stoichiometry: 1.0
species: 868903

934205
type: SpeciesReference
stoichiometry: 1.0
species: 868891

868891
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: UDP

934265
type: LocalParameter
value: 500.0

934253
type: LocalParameter
value: 0.0

934241
type: LocalParameter
value: 1000.0

934229
type: LocalParameter
value: 0.0

934193
type: SpeciesReference
stoichiometry: 1.0
species: 867216

864175
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: docosapentaenoate (C22:5, n-3)

968292
type: Reaction
kinetic law: 968328
product: 968316
reactant: 968304
notes: GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: triose-phosphate isomerase

968376
type: LocalParameter
value: 0.0

968364
type: LocalParameter
value: 0.0

968352
type: LocalParameter
value: 1000.0

968340
type: LocalParameter
value: -1000.0

968316
type: SpeciesReference
stoichiometry: 1.0
species: 866950

866950
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Glyceraldehyde 3-phosphate

968304
type: SpeciesReference
stoichiometry: 1.0
species: 866209

866209
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Dihydroxyacetone phosphate

914026
type: Reaction
fast: false
product: 914086
product: 914074
kinetic law: 914110
reactant: 914062
notes: GENE_ASSOCIATION: (NM_001009185.1 or NM_015256.2 or NM_203379.1 or NM_016234.3 or NM_203380.1 or NM_001995.2 or NM_203372.1 or NM_004457.3 or NM_004458.1 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
name: fatty-acid--CoA ligase (heptadecanoate, C17:0)
reversible: true
reactant: 914050
reactant: 914038
product: 914098

914086
type: SpeciesReference
stoichiometry: 1.0
species: 867408

867408
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: heptadecanoyl CoA (C17:0CoA)

914074
type: SpeciesReference
stoichiometry: 1.0
species: 865568

914158
type: LocalParameter
value: 0.0

914146
type: LocalParameter
value: 0.0

914134
type: LocalParameter
value: 1000.0

914122
type: LocalParameter
value: -1000.0

914062
type: SpeciesReference
stoichiometry: 1.0
species: 867396

867396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: heptadecanoate (C17:0)

914050
type: SpeciesReference
stoichiometry: 1.0
species: 865883

914038
type: SpeciesReference
stoichiometry: 1.0
species: 865641

914098
type: SpeciesReference
stoichiometry: 1.0
species: 868361

866732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Fructose 1-phosphate

868169
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: propionyl-carnitine

872728
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ptdca_b

877665
type: Reaction
kinetic law: 877701
product: 877689
reactant: 877677
fast: false
reversible: true
name: D-Mannose exchange

877750
type: LocalParameter
value: 500.0

877738
type: LocalParameter
value: 0.0

877725
type: LocalParameter
value: 1000.0

877713
type: LocalParameter
value: 0.0

877689
type: SpeciesReference
stoichiometry: 1.0
species: 872533

877677
type: SpeciesReference
stoichiometry: 1.0
species: 864552

864552
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: D-Mannose

866101
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoate (C22:5, n-3)

942496
type: Reaction
product: 942556
product: 942544
kinetic law: 942568
fast: false
reactant: 942508
product: 942532
reactant: 942520
reversible: true
name: L-lactate dehydrogenase
notes: GENE_ASSOCIATION: ((NM_002300.3 and NM_005566.1) or NM_033195.1 or NM_002300.3 or NM_002301.2 or NM_017448.1 or NM_018314.2 or NM_144972.3 or NM_005566.1) GENE_LIST: NM_002300.3 NM_002301.2 NM_005566.1 NM_017448.1 NM_018314.2 NM_033195.1 NM_144972.3 SUBSYSTEM: Glycolysis/Gluconeogenesis

942556
type: SpeciesReference
stoichiometry: 1.0
species: 868493

942544
type: SpeciesReference
stoichiometry: 1.0
species: 867806

942616
type: LocalParameter
value: 0.0

942604
type: LocalParameter
value: 0.0

942592
type: LocalParameter
value: 1000.0

942580
type: LocalParameter
value: -1000.0

942508
type: SpeciesReference
stoichiometry: 1.0
species: 867577

867577
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Lactate

942532
type: SpeciesReference
stoichiometry: 1.0
species: 867216

942520
type: SpeciesReference
stoichiometry: 1.0
species: 867794

939361
type: Reaction
kinetic law: 939409
product: 939397
reactant: 939385
reactant: 939373
notes: SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: true
name: S-(hydroxymethyl)glutathione synthase

939457
type: LocalParameter
value: 0.0

939445
type: LocalParameter
value: 0.0

939433
type: LocalParameter
value: 1000.0

939421
type: LocalParameter
value: -1000.0

939397
type: SpeciesReference
stoichiometry: 1.0
species: 867384

867384
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: S-(Hydroxymethyl)glutathione

939385
type: SpeciesReference
stoichiometry: 1.0
species: 867192

939373
type: SpeciesReference
stoichiometry: 1.0
species: 866792

866792
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Formaldehyde

875813
type: Reaction
kinetic law: 875850
product: 875838
reactant: 875825
fast: false
reversible: true
name: D-Fructose exchange

875899
type: LocalParameter
value: 500.0

875887
type: LocalParameter
value: 0.0

875875
type: LocalParameter
value: 1000.0

875863
type: LocalParameter
value: 0.0

875838
type: SpeciesReference
stoichiometry: 1.0
species: 872303

872303
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: fru_b

875825
type: SpeciesReference
stoichiometry: 1.0
species: 864320

864320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: D-Fructose

940232
type: Reaction
product: 940269
kinetic law: 940308
product: 940282
product: 940295
reactant: 940257
reactant: 940245
notes: GENE_ASSOCIATION: ((NM_004135.2 and NM_005530.2 and NM_174855.1) or (NM_005530.2 and NM_006899.2 and NM_174869.1) or (NM_005530.2 and NM_174855.1 and NM_174869.1) or (NM_004135.2 and NM_005530.2 and NM_174856.1) or (NM_004135.2 and NM_005530.2 and NM_006899.2) or (NM_005530.2 and NM_174856.1 and NM_174869.1)) GENE_LIST: NM_004135.2 NM_005530.2 NM_006899.2 NM_174855.1 NM_174856.1 NM_174869.1 SUBSYSTEM: Citrate Cycle (TCA)
reversible: false
fast: false
name: Isocitrate dehydrogenase (NAD+)

940269
type: SpeciesReference
stoichiometry: 1.0
species: 869448

940357
type: LocalParameter
value: 500.0

940345
type: LocalParameter
value: 0.0

940332
type: LocalParameter
value: 1000.0

940320
type: LocalParameter
value: 0.0

940282
type: SpeciesReference
stoichiometry: 1.0
species: 869631

940295
type: SpeciesReference
stoichiometry: 1.0
species: 870461

940257
type: SpeciesReference
stoichiometry: 1.0
species: 870448

940245
type: SpeciesReference
stoichiometry: 1.0
species: 870299

872471
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ile_L_b

868529
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Sedoheptulose 7-phosphate

935036
type: Reaction
reversible: false
fast: false
kinetic law: 935110
name: glycine N-methyltransferase
product: 935072
reactant: 935060
notes: GENE_ASSOCIATION: NM_018960.4 GENE_LIST: NM_018960.4 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 935097
reactant: 935048
product: 935085

935161
type: LocalParameter
value: 500.0

935148
type: LocalParameter
value: 0.0

935135
type: LocalParameter
value: 1000.0

935123
type: LocalParameter
value: 0.0

935072
type: SpeciesReference
stoichiometry: 1.0
species: 865472

865472
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: S-Adenosyl-L-homocysteine

935060
type: SpeciesReference
stoichiometry: 1.0
species: 867095

935097
type: SpeciesReference
stoichiometry: 1.0
species: 868541

935048
type: SpeciesReference
stoichiometry: 1.0
species: 865544

865544
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: S-Adenosyl-L-methionine

935085
type: SpeciesReference
stoichiometry: 1.0
species: 867216

870575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecadienoyl-CoA (C18:2CoA, n-6)

869824
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosenoyl-CoA (C20:1CoA, n-9)

943433
type: Reaction
product: 943517
reactant: 943445
reactant: 943457
product: 943493
reactant: 943481
reversible: false
reactant: 943469
kinetic law: 943529
product: 943505
name: Lathosterol oxidase
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
fast: false

943517
type: SpeciesReference
stoichiometry: 1.0
species: 871457

943445
type: SpeciesReference
stoichiometry: 1.0
species: 871275

871275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 5alpha-Cholesta-7,24-dien-3beta-ol

943457
type: SpeciesReference
stoichiometry: 1.0
species: 871385

943493
type: SpeciesReference
stoichiometry: 1.0
species: 871312

871312
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 7-Dehydrodesmosterol

943481
type: SpeciesReference
stoichiometry: 1.0
species: 871481

943469
type: SpeciesReference
stoichiometry: 1.0
species: 871469

943578
type: LocalParameter
value: 500.0

943566
type: LocalParameter
value: 0.0

943553
type: LocalParameter
value: 1000.0

943541
type: LocalParameter
value: 0.0

943505
type: SpeciesReference
stoichiometry: 2.0
species: 871397

869327
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 4-Methyl-2-oxopentanoate

899275
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reactant: 899299
fast: false
reactant: 899287
product: 899323
name: eicosatrienoyl carnitine transport (C20:3Crn, n9)
product: 899311
kinetic law: 899335

899299
type: SpeciesReference
stoichiometry: 1.0
species: 869655

899287
type: SpeciesReference
stoichiometry: 1.0
species: 866671

866671
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatrienoyl carnitine (C20:3Crn, n9)

899323
type: SpeciesReference
stoichiometry: 1.0
species: 869909

899311
type: SpeciesReference
stoichiometry: 1.0
species: 865907

899383
type: LocalParameter
value: 0.0

899371
type: LocalParameter
value: 0.0

899359
type: LocalParameter
value: 1000.0

899347
type: LocalParameter
value: -1000.0

925460
type: Reaction
fast: false
reactant: 925472
product: 925520
product: 925532
reactant: 925496
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
kinetic law: 925580
product: 925556
name: fatty acid synthase (n-C20:0)
product: 925544
reactant: 925508
reactant: 925484
product: 925568
reversible: false

925472
type: SpeciesReference
stoichiometry: 3.0
species: 867216

925520
type: SpeciesReference
stoichiometry: 1.0
species: 865871

925532
type: SpeciesReference
stoichiometry: 1.0
species: 865883

925496
type: SpeciesReference
stoichiometry: 2.0
species: 867830

925628
type: LocalParameter
value: 500.0

925616
type: LocalParameter
value: 0.0

925604
type: LocalParameter
value: 1000.0

925592
type: LocalParameter
value: 0.0

925556
type: SpeciesReference
stoichiometry: 1.0
species: 867228

925544
type: SpeciesReference
stoichiometry: 1.0
species: 866452

866452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Eicosanoate (n-C20:0)

925508
type: SpeciesReference
stoichiometry: 1.0
species: 867891

867891
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecanoate (n-C18:0)

925484
type: SpeciesReference
stoichiometry: 1.0
species: 867638

867638
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Malonyl-CoA

925568
type: SpeciesReference
stoichiometry: 2.0
species: 867818

904461
type: Reaction
product: 904497
name: carnitine O-aceyltransferase, peroxisomal
fast: false
reactant: 904485
reversible: true
product: 904509
kinetic law: 904521
reactant: 904473
notes: GENE_ASSOCIATION: NM_004003.2 GENE_LIST: NM_004003.2 SUBSYSTEM: Carnitine Shuttle

904497
type: SpeciesReference
stoichiometry: 1.0
species: 871737

871737
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Coenzyme A

904485
type: SpeciesReference
stoichiometry: 1.0
species: 871953

871953
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Propanoyl-CoA (C3:0CoA)

904509
type: SpeciesReference
stoichiometry: 1.0
species: 871929

904569
type: LocalParameter
value: 0.0

904557
type: LocalParameter
value: 0.0

904545
type: LocalParameter
value: 1000.0

904533
type: LocalParameter
value: -1000.0

904473
type: SpeciesReference
stoichiometry: 1.0
species: 871749

871749
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: L-Carnitine

908445
type: Reaction
reversible: false
reactant: 908493
reactant: 908481
product: 908517
reactant: 908457
product: 908529
notes: SUBSYSTEM: Fatty Acid Synthesis
product: 908505
reactant: 908469
fast: false
kinetic law: 908541
name: Myristoyl-CoA desaturase (n-C14:0CoA -> C14:1CoA, n-7)

908493
type: SpeciesReference
stoichiometry: 1.0
species: 868686

868686
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Tetradecanoyl-CoA (n-C14:0CoA)

908481
type: SpeciesReference
stoichiometry: 1.0
species: 867854

908517
type: SpeciesReference
stoichiometry: 1.0
species: 867818

908457
type: SpeciesReference
stoichiometry: 1.0
species: 867216

908529
type: SpeciesReference
stoichiometry: 1.0
species: 868710

868710
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: tetradecenoyl-CoA (C14:1CoA, n-7)

908505
type: SpeciesReference
stoichiometry: 2.0
species: 867228

908469
type: SpeciesReference
stoichiometry: 1.0
species: 867830

908589
type: LocalParameter
value: 500.0

908577
type: LocalParameter
value: 0.0

908565
type: LocalParameter
value: 1000.0

908553
type: LocalParameter
value: 0.0

965723
type: Reaction
product: 965795
reactant: 965747
product: 965771
notes: GENE_ASSOCIATION: (NM_170740.1 or NM_001080.3) GENE_LIST: NM_001080.3 NM_170740.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
product: 965783
name: succinate-semialdehyde dehydrogenase, mitochondrial
kinetic law: 965807
reversible: false
reactant: 965759
reactant: 965735

965795
type: SpeciesReference
stoichiometry: 1.0
species: 870984

870984
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Succinate

965747
type: SpeciesReference
stoichiometry: 1.0
species: 870448

965771
type: SpeciesReference
stoichiometry: 2.0
species: 870140

965783
type: SpeciesReference
stoichiometry: 1.0
species: 870461

965855
type: LocalParameter
value: 500.0

965843
type: LocalParameter
value: 0.0

965831
type: LocalParameter
value: 1000.0

965819
type: LocalParameter
value: 0.0

965759
type: SpeciesReference
stoichiometry: 1.0
species: 871009

871009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Succinic semialdehyde

965735
type: SpeciesReference
stoichiometry: 1.0
species: 870152

866683
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Ethanol

889202
type: Reaction
kinetic law: 889238
product: 889226
reactant: 889214
notes: GENE_ASSOCIATION: (NM_012244.2 or NM_001048164.1 or NM_001126106.1 or NM_182728.1 or NM_003982.3 or NM_003486.5 or NM_001126105.1 or NM_018018.2 or NM_001008539.1 or NM_003046.2 or NM_003045.3 or NM_032803.3) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_001126105.1 NM_001126106.1 NM_003045.3 NM_003046.2 NM_003486.5 NM_003982.3 NM_012244.2 NM_018018.2 NM_032803.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Arginine transport, blood

889287
type: LocalParameter
value: 0.0

889275
type: LocalParameter
value: 0.0

889263
type: LocalParameter
value: 1000.0

889251
type: LocalParameter
value: -1000.0

889226
type: SpeciesReference
stoichiometry: 1.0
species: 865593

889214
type: SpeciesReference
stoichiometry: 1.0
species: 864078

864078
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Arginine

864844
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Tyrosine

872607
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ocdcea9_b

935302
type: Reaction
reactant: 935314
name: glutathione oxidoreductase
fast: false
reversible: false
reactant: 935338
kinetic law: 935374
reactant: 935326
notes: GENE_ASSOCIATION: NM_000637.2 GENE_LIST: NM_000637.2 SUBSYSTEM: Glutamate metabolism
product: 935362
product: 935350

935314
type: SpeciesReference
stoichiometry: 1.0
species: 867180

935338
type: SpeciesReference
stoichiometry: 1.0
species: 867830

935423
type: LocalParameter
value: 500.0

935411
type: LocalParameter
value: 0.0

935398
type: LocalParameter
value: 1000.0

935386
type: LocalParameter
value: 0.0

935326
type: SpeciesReference
stoichiometry: 1.0
species: 867216

935362
type: SpeciesReference
stoichiometry: 1.0
species: 867818

935350
type: SpeciesReference
stoichiometry: 2.0
species: 867192

968388
type: Reaction
notes: GENE_ASSOCIATION: (NM_182729.1 or NM_182743.1 or NM_001093771.1 or NM_182742.1 or NM_003330.2) GENE_LIST: NM_001093771.1 NM_003330.2 NM_182729.1 NM_182742.1 NM_182743.1 SUBSYSTEM: Tyrosine metabolism
reactant: 968400
name: thioredoxin reductase (NADPH)
reversible: true
fast: false
reactant: 968424
kinetic law: 968460
product: 968448
product: 968436
reactant: 968412

968400
type: SpeciesReference
stoichiometry: 1.0
species: 867216

968424
type: SpeciesReference
stoichiometry: 1.0
species: 868794

868794
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Oxidized thioredoxin

968508
type: LocalParameter
value: 0.0

968496
type: LocalParameter
value: 0.0

968484
type: LocalParameter
value: 1000.0

968472
type: LocalParameter
value: -1000.0

968448
type: SpeciesReference
stoichiometry: 1.0
species: 868806

868806
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Reduced thioredoxin

968436
type: SpeciesReference
stoichiometry: 1.0
species: 867818

968412
type: SpeciesReference
stoichiometry: 1.0
species: 867830

871688
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA

878439
type: Reaction
kinetic law: 878475
product: 878463
reactant: 878451
fast: false
reversible: true
name: octadecatrienoate (C18:3, n-6) exchange

878523
type: LocalParameter
value: 500.0

878511
type: LocalParameter
value: 0.0

878499
type: LocalParameter
value: 1000.0

878487
type: LocalParameter
value: 0.0

878463
type: SpeciesReference
stoichiometry: 1.0
species: 872631

872631
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ocdctra6_b

878451
type: SpeciesReference
stoichiometry: 1.0
species: 864650

864650
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: octadecatrienoate (C18:3, n-6)

882847
type: Reaction
fast: false
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 882859
reversible: true
kinetic law: 882907
product: 882895
reactant: 882871
name: acyl-CoA dehydrogenase, mitochondrial
product: 882883

882859
type: SpeciesReference
stoichiometry: 1.0
species: 869945

882955
type: LocalParameter
value: 0.0

882943
type: LocalParameter
value: 0.0

882931
type: LocalParameter
value: 1000.0

882919
type: LocalParameter
value: -1000.0

882895
type: SpeciesReference
stoichiometry: 1.0
species: 869957

882871
type: SpeciesReference
stoichiometry: 1.0
species: 870323

870323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Isovaleryl-CoA

882883
type: SpeciesReference
stoichiometry: 1.0
species: 869254

871106
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: tridecanoyl-CoA (C13:0CoA)

871554
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

886284
type: Reaction
kinetic law: 886321
product: 886309
reactant: 886297
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: alphaketobutyrate transport (mitochondrial)

886369
type: LocalParameter
value: 0.0

886357
type: LocalParameter
value: 0.0

886345
type: LocalParameter
value: 1000.0

886333
type: LocalParameter
value: -1000.0

886309
type: SpeciesReference
stoichiometry: 1.0
species: 864989

886297
type: SpeciesReference
stoichiometry: 1.0
species: 869170

869691
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Dodecanoyl-CoA (n-C12:0CoA)

943169
type: Reaction
product: 943265
reactant: 943193
kinetic law: 943277
product: 943241
reactant: 943205
reversible: false
name: cytochrome P450 lanosterol 14-alpha-demethylase
fast: false
product: 943229
reactant: 943181
notes: GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Biosynthesis
product: 943253
reactant: 943217

943265
type: SpeciesReference
stoichiometry: 3.0
species: 871457

943193
type: SpeciesReference
stoichiometry: 1.0
species: 871409

871409
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Lanosterol

943325
type: LocalParameter
value: 500.0

943313
type: LocalParameter
value: 0.0

943301
type: LocalParameter
value: 1000.0

943289
type: LocalParameter
value: 0.0

943241
type: SpeciesReference
stoichiometry: 1.0
species: 871337

871337
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Formate

943205
type: SpeciesReference
stoichiometry: 3.0
species: 871469

943229
type: SpeciesReference
stoichiometry: 1.0
species: 871178

871178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 4,4-dimethylcholesta-8,14,24-trienol

943181
type: SpeciesReference
stoichiometry: 2.0
species: 871385

943253
type: SpeciesReference
stoichiometry: 4.0
species: 871397

943217
type: SpeciesReference
stoichiometry: 3.0
species: 871481

912163
type: Reaction
kinetic law: 912211
product: 912199
reactant: 912187
reactant: 912175
notes: GENE_ASSOCIATION: (NM_004092.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Isoleucine degradation
fast: false
reversible: true
name: enoyl-CoA hydratase, mitochondrial

912259
type: LocalParameter
value: 0.0

912247
type: LocalParameter
value: 0.0

912235
type: LocalParameter
value: 1000.0

912223
type: LocalParameter
value: -1000.0

912199
type: SpeciesReference
stoichiometry: 1.0
species: 869230

912187
type: SpeciesReference
stoichiometry: 1.0
species: 870152

912175
type: SpeciesReference
stoichiometry: 1.0
species: 869134

869134
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: trans-2-Methylbut-2-enoyl-CoA

882725
type: Reaction
notes: GENE_ASSOCIATION: NM_138326.1 GENE_LIST: NM_138326.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reactant: 882738
product: 882774
name: aminocarboxymuconate-semialdehyde decarboxylase
reactant: 882750
product: 882762
kinetic law: 882786
reversible: false

882738
type: SpeciesReference
stoichiometry: 1.0
species: 865424

882774
type: SpeciesReference
stoichiometry: 1.0
species: 865871

882750
type: SpeciesReference
stoichiometry: 1.0
species: 867216

882762
type: SpeciesReference
stoichiometry: 1.0
species: 865581

865581
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Aminomuconate semialdehyde

882834
type: LocalParameter
value: 500.0

882822
type: LocalParameter
value: 0.0

882810
type: LocalParameter
value: 1000.0

882798
type: LocalParameter
value: 0.0

962917
type: Reaction
kinetic law: 962990
reactant: 962929
product: 962953
reactant: 962941
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotides
fast: false
name: ribonucleoside-diphosphate reductase (UDP)
reversible: false
product: 962965
product: 962978

963038
type: LocalParameter
value: 500.0

963026
type: LocalParameter
value: 0.0

963014
type: LocalParameter
value: 1000.0

963002
type: LocalParameter
value: 0.0

962929
type: SpeciesReference
stoichiometry: 1.0
species: 868806

962953
type: SpeciesReference
stoichiometry: 1.0
species: 866392

866392
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dUDP

962941
type: SpeciesReference
stoichiometry: 1.0
species: 868891

962965
type: SpeciesReference
stoichiometry: 1.0
species: 867228

962978
type: SpeciesReference
stoichiometry: 1.0
species: 868794

868457
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: O-Phospho-L-serine

864759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Pyruvate

920855
type: Reaction
product: 920951
reactant: 920879
product: 920927
fast: false
product: 920939
reactant: 920903
reactant: 920891
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 ... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_006111.1... NM_014049.3 SUBSYSTEM: Fatty acid oxidation
kinetic law: 920975
name: Beta oxidation of fatty acid
reactant: 920915
reactant: 920867
reversible: false
product: 920963

920951
type: SpeciesReference
stoichiometry: 8.0
species: 870140

920879
type: SpeciesReference
stoichiometry: 5.0
species: 869945

920927
type: SpeciesReference
stoichiometry: 9.0
species: 869412

920939
type: SpeciesReference
stoichiometry: 5.0
species: 869957

920903
type: SpeciesReference
stoichiometry: 8.0
species: 870448

920891
type: SpeciesReference
stoichiometry: 8.0
species: 870152

921023
type: LocalParameter
value: 500.0

921011
type: LocalParameter
value: 0.0

920999
type: LocalParameter
value: 1000.0

920987
type: LocalParameter
value: 0.0

920915
type: SpeciesReference
stoichiometry: 1.0
species: 870599

870599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecatrienoyl-CoA (C18:3CoA, n-3)

920867
type: SpeciesReference
stoichiometry: 8.0
species: 869643

920963
type: SpeciesReference
stoichiometry: 8.0
species: 870461

939567
type: Reaction
reactant: 939579
reactant: 939591
fast: false
kinetic law: 939627
product: 939603
product: 939615
notes: GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
reversible: false
name: 4-hydroxyphenylpyruvate dioxygenase

939579
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species: 865025

939591
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867324
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initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Homogentisate

902525
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reactant: 902549
name: octadecanoyl carnitine transport (C18:0Crn)
product: 902573
kinetic law: 902585
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reactant: 902537
product: 902561
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

902549
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species: 869655

902573
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species: 870972

870972
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Stearoylcarnitine (C18:0Crn)

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902621
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902609
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902597
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species: 868637

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initial concentration: NaN
initial amount: NaN
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name: Stearoylcarnitine (C18:0Crn)

902561
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species: 865907

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boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
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boundary condition: true
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initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: cholse_Hsa_Hep_b

927415
type: Reaction
kinetic law: 927511
name: formyltetrahydrofolate dehydrogenase
notes: GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Vitamins & Cofactor Biosynthesis
fast: false
reactant: 927439
product: 927499
reversible: false
product: 927487
product: 927463
reactant: 927451
reactant: 927427
product: 927475

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species: 867228

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868758
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5,6,7,8-Tetrahydrofolate

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species: 867830

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species: 865871

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species: 867818

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species: 864881

864881
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 10-Formyltetrahydrofolate

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species: 867216

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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: arg_L_b

890461
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reversible: true
name: aspartate transaminase, mitochondrial
reactant: 890485
kinetic law: 890521
product: 890509
fast: false
notes: GENE_ASSOCIATION: (NM_000353.1 or NM_002080.2) GENE_LIST: NM_000353.1 NM_002080.2 SUBSYSTEM: Tyrosine metabolism
reactant: 890473
product: 890497

890485
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species: 871118

871118
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Tyrosine

890570
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890558
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value: 0.0

890546
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value: 1000.0

890533
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890509
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stoichiometry: 1.0
species: 870055

890473
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species: 869448

890497
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species: 869194

869194
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3-(4-Hydroxyphenyl)pyruvate

970679
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_031432.1 or NM_012474.3) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Biosynthesis
reversible: false
reactant: 970691
reactant: 970703
kinetic law: 970752
product: 970715
name: uridine kinase (ATP:Uridine)
product: 970727
product: 970740

970691
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species: 865641

970703
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stoichiometry: 1.0
species: 868976

868976
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Uridine

970800
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value: 500.0

970788
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value: 0.0

970776
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value: 1000.0

970764
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stoichiometry: 1.0
species: 865460

970727
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species: 867216

970740
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species: 868927

882327
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product: 882375
reversible: true
reactant: 882339
fast: false
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
kinetic law: 882387
name: acetoacetate transport via proton symport, mitochondrial
reactant: 882351
product: 882363

882375
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stoichiometry: 1.0
species: 870140

882339
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species: 865388

865388
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetoacetate

882435
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value: 0.0

882423
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value: 0.0

882411
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value: 1000.0

882399
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value: -1000.0

882351
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stoichiometry: 1.0
species: 867216

882363
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species: 869400

869400
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Acetoacetate

881987
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kinetic law: 882035
product: 882023
product: 882011
reactant: 881999
notes: GENE_ASSOCIATION: NM_005891.1 GENE_LIST: NM_005891.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: acetyl-CoA C-acetyltransferase

882084
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value: 0.0

882071
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value: 0.0

882059
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value: 1000.0

882047
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value: -1000.0

882023
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stoichiometry: 1.0
species: 865883

882011
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stoichiometry: 1.0
species: 865351

865351
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetoacetyl-CoA

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species: 865412

865412
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetyl-CoA

889974
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fast: false
reversible: true
name: aspartate transaminase, mitochondrial
reactant: 889986
reactant: 889998
notes: GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Alanine and Aspartate Metabolism
product: 890023
product: 890010
kinetic law: 890036

889986
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stoichiometry: 1.0
species: 869448

889998
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stoichiometry: 1.0
species: 869497

869497
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Aspartate

890023
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stoichiometry: 1.0
species: 870551

890010
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stoichiometry: 1.0
species: 870055

890084
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value: 0.0

890072
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value: 0.0

890060
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value: 1000.0

890048
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value: -1000.0

934059
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kinetic law: 934096
product: 934084
reactant: 934071
notes: GENE_ASSOCIATION: (NM_004925.3 or NM_001170.1) GENE_LIST: NM_001170.1 NM_004925.3 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: glycerol transport in/out via diffusion reversible

934144
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value: 0.0

934132
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value: 0.0

934120
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value: 1000.0

934108
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value: -1000.0

934084
type: SpeciesReference
stoichiometry: 1.0
species: 864393

864393
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Glycerol

934071
type: SpeciesReference
stoichiometry: 1.0
species: 867119

968905
type: Reaction
kinetic law: 968953
product: 968941
reactant: 968929
reactant: 968917
notes: GENE_ASSOCIATION: NM_005651.1 GENE_LIST: NM_005651.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: false
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

969001
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value: 500.0

968989
type: LocalParameter
value: 0.0

968977
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value: 1000.0

968965
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value: 0.0

968941
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stoichiometry: 1.0
species: 865339

865339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Formylkynurenine

968929
type: SpeciesReference
stoichiometry: 1.0
species: 868830

968917
type: SpeciesReference
stoichiometry: 1.0
species: 867854

871021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Tetradecanoyl-CoA (n-C14:0CoA)

965157
type: Reaction
reversible: false
name: non-enzymatic reaction
notes: SUBSYSTEM: Cysteine Metabolism
product: 965217
product: 965193
fast: false
kinetic law: 965229
product: 965205
reactant: 965169
reactant: 965181

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species: 868565

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stoichiometry: 2.0
species: 867216

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value: 500.0

965265
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value: 0.0

965253
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value: 1000.0

965241
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value: 0.0

965205
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stoichiometry: 1.0
species: 868493

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stoichiometry: 1.0
species: 867228

965181
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stoichiometry: 1.0
species: 868613

868613
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Sulfinylpyruvate

864662
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: octadecadienoate (C18:2, n-6)

866647
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatrienoyl-CoA (C20:3CoA, n-9)

877473
type: Reaction
kinetic law: 877509
product: 877497
reactant: 877485
fast: false
reversible: true
name: L-Leucine exchange

877557
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value: -0.00899771

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type: LocalParameter
value: 0.0

877533
type: LocalParameter
value: 0.0

877521
type: LocalParameter
value: -0.01799542

877497
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stoichiometry: 1.0
species: 872508

872508
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: leu_L_b

877485
type: SpeciesReference
stoichiometry: 1.0
species: 864527

967796
type: Reaction
product: 967834
kinetic law: 967858
name: transketolase
product: 967846
reversible: true
fast: false
notes: GENE_ASSOCIATION: (NM_032136.3 or NM_012253.2 or NM_001064.1) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 967822
reactant: 967809

967834
type: SpeciesReference
stoichiometry: 1.0
species: 866950

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type: LocalParameter
value: 0.0

967894
type: LocalParameter
value: 0.0

967882
type: LocalParameter
value: 1000.0

967870
type: LocalParameter
value: -1000.0

967846
type: SpeciesReference
stoichiometry: 1.0
species: 868529

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stoichiometry: 1.0
species: 869061

869061
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Xylulose 5-phosphate

967809
type: SpeciesReference
stoichiometry: 1.0
species: 868505

950563
type: Reaction
name: 5'-nucleotidase (dCMP)
reactant: 950587
fast: false
kinetic law: 950623
reversible: false
reactant: 950575
product: 950599
product: 950611
notes: GENE_ASSOCIATION: (NM_014595.1 or NM_001002006.1 or NM_033253.2) GENE_LIST: NM_001002006.1 NM_014595.1 NM_033253.2 SUBSYSTEM: Pyrimidine Catabolism

950587
type: SpeciesReference
stoichiometry: 1.0
species: 867228

950671
type: LocalParameter
value: 500.0

950659
type: LocalParameter
value: 0.0

950647
type: LocalParameter
value: 1000.0

950635
type: LocalParameter
value: 0.0

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type: SpeciesReference
stoichiometry: 1.0
species: 866051

866051
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dCMP

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type: SpeciesReference
stoichiometry: 1.0
species: 866137

866137
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Deoxycytidine

950611
type: SpeciesReference
stoichiometry: 1.0
species: 868265

872242
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ecstea9_b

880283
type: Reaction
fast: false
reactant: 880295
reversible: true
kinetic law: 880343
name: 2-oxoadipate shuttle (cytosol/mitochondria)
notes: GENE_ASSOCIATION: NM_030631.1 GENE_LIST: NM_030631.1 SUBSYSTEM: Transport, Mitochondrial
product: 880319
reactant: 880307
product: 880331

880295
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stoichiometry: 1.0
species: 865001

865001
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Oxoadipate

880392
type: LocalParameter
value: 0.0

880379
type: LocalParameter
value: 0.0

880367
type: LocalParameter
value: 1000.0

880355
type: LocalParameter
value: -1000.0

880319
type: SpeciesReference
stoichiometry: 1.0
species: 865520

880307
type: SpeciesReference
stoichiometry: 1.0
species: 869448

880331
type: SpeciesReference
stoichiometry: 1.0
species: 869182

869182
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 2-Oxoadipate

891754
type: Reaction
reactant: 891791
reactant: 891766
product: 891803
product: 891815
name: C-14 sterol reductase, endoplasmic reticulum
reactant: 891779
kinetic law: 891827
reversible: false
notes: GENE_ASSOCIATION: NM_003273.1 GENE_LIST: NM_003273.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false

891791
type: SpeciesReference
stoichiometry: 1.0
species: 871469

891766
type: SpeciesReference
stoichiometry: 1.0
species: 871178

891803
type: SpeciesReference
stoichiometry: 1.0
species: 871190

891815
type: SpeciesReference
stoichiometry: 1.0
species: 871457

891779
type: SpeciesReference
stoichiometry: 1.0
species: 871385

891875
type: LocalParameter
value: 500.0

891863
type: LocalParameter
value: 0.0

891851
type: LocalParameter
value: 1000.0

891839
type: LocalParameter
value: 0.0

864296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Ethanol

903609
type: Reaction
kinetic law: 903670
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_001031847.1 or NM_004377.2 or NM_152247.1 or NM_001876.2 or NM_152246.1 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 903658
name: carnitine tetradecenoyltransferase (C14:1Crn, n7)
product: 903645
fast: false
reactant: 903633
reactant: 903621
reversible: true

903718
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value: 0.0

903706
type: LocalParameter
value: 0.0

903694
type: LocalParameter
value: 1000.0

903682
type: LocalParameter
value: -1000.0

903658
type: SpeciesReference
stoichiometry: 1.0
species: 868722

868722
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: tetradecenoyl carnitine (C14:1Crn, n-7)

903645
type: SpeciesReference
stoichiometry: 1.0
species: 865883

903633
type: SpeciesReference
stoichiometry: 1.0
species: 868710

903621
type: SpeciesReference
stoichiometry: 1.0
species: 865907

966265
type: Reaction
product: 966301
kinetic law: 966326
reversible: true
fast: false
reactant: 966289
notes: GENE_ASSOCIATION: ((NM_001035513.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_003000.1 and NM_003001.3 and NM_003002.1 and NM_004168.1) or (NM_001035512.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_001035511.1 and NM_003000.1 and NM_003002.1 and NM_004168.1)) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 NM_003000.1 NM_003001.3 NM_003002.1 NM_004168.1 SUBSYSTEM: Citrate Cycle (TCA)
name: succinate dehydrogenase
reactant: 966277
product: 966314

966301
type: SpeciesReference
stoichiometry: 1.0
species: 870018

870018
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Fumarate

966374
type: LocalParameter
value: 0.0

966362
type: LocalParameter
value: 0.0

966350
type: LocalParameter
value: 1000.0

966338
type: LocalParameter
value: -1000.0

966289
type: SpeciesReference
stoichiometry: 1.0
species: 871130

966277
type: SpeciesReference
stoichiometry: 1.0
species: 870984

966314
type: SpeciesReference
stoichiometry: 1.0
species: 870923

864905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Phospho-D-glyceroyl phosphate

938468
type: Reaction
name: hydroxymethylbilane synthase
fast: false
reactant: 938480
kinetic law: 938528
product: 938504
notes: GENE_ASSOCIATION: (NM_000190.3 or NM_001024382.1) GENE_LIST: NM_000190.3 NM_001024382.1 SUBSYSTEM: Heme Biosynthesis
product: 938516
reactant: 938492
reversible: false

938480
type: SpeciesReference
stoichiometry: 1.0
species: 867228

938576
type: LocalParameter
value: 500.0

938564
type: LocalParameter
value: 0.0

938552
type: LocalParameter
value: 1000.0

938540
type: LocalParameter
value: 0.0

938504
type: SpeciesReference
stoichiometry: 1.0
species: 867360

867360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Hydroxymethylbilane

938516
type: SpeciesReference
stoichiometry: 4.0
species: 867842

938492
type: SpeciesReference
stoichiometry: 4.0
species: 868337

868337
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Porphobilinogen

867252
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Bicarbonate

966650
type: Reaction
name: Succinate--CoA ligase (GDP-forming)
product: 966722
reactant: 966662
product: 966710
reactant: 966674
product: 966698
fast: false
notes: GENE_ASSOCIATION: (NM_003848.1 and NM_003849.1) GENE_LIST: NM_003848.1 NM_003849.1 SUBSYSTEM: Citrate Cycle (TCA)
kinetic law: 966734
reactant: 966686
reversible: true

966722
type: SpeciesReference
stoichiometry: 1.0
species: 870996

870996
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Succinyl-CoA

966662
type: SpeciesReference
stoichiometry: 1.0
species: 869643

966710
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stoichiometry: 1.0
species: 870803

966674
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stoichiometry: 1.0
species: 870128

870128
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: GTP

966698
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species: 870030

870030
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: GDP

966783
type: LocalParameter
value: 0.0

966771
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value: 0.0

966758
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value: 1000.0

966746
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value: -1000.0

966686
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stoichiometry: 1.0
species: 870984

883812
type: Reaction
product: 883860
reactant: 883824
reactant: 883848
reversible: false
fast: false
name: acetyl-CoA synthetase
product: 883872
kinetic law: 883896
product: 883884
reactant: 883836
notes: GENE_ASSOCIATION: (NM_023928.2 or NM_018677.2 or NM_139274.1) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Pyruvate Metabolism

883860
type: SpeciesReference
stoichiometry: 1.0
species: 865412

883824
type: SpeciesReference
stoichiometry: 1.0
species: 865375

865375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetate

883848
type: SpeciesReference
stoichiometry: 1.0
species: 865883

883872
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stoichiometry: 1.0
species: 865568

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value: 500.0

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value: 0.0

883921
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value: 1000.0

883908
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value: 0.0

883884
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stoichiometry: 1.0
species: 868361

883836
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stoichiometry: 1.0
species: 865641

865484
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate

946893
type: Reaction
kinetic law: 946966
product: 946942
reactant: 946917
product: 946954
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 946929
reversible: false
name: (S)-methylmalonyl-CoA hydrolase
fast: false
reactant: 946905

947015
type: LocalParameter
value: 500.0

947003
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value: 0.0

946991
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value: 1000.0

946978
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value: 0.0

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species: 870152

946917
type: SpeciesReference
stoichiometry: 1.0
species: 870140

946954
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species: 870434

946929
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species: 870395

946905
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species: 869643

951467
type: Reaction
kinetic law: 951503
product: 951491
reactant: 951479
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: O2 transport (diffusion)

951551
type: LocalParameter
value: 0.0

951539
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value: 0.0

951527
type: LocalParameter
value: 1000.0

951515
type: LocalParameter
value: -1000.0

951491
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stoichiometry: 1.0
species: 870526

870526
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: O2

951479
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species: 867854

968171
type: Reaction
product: 968207
name: thymidylate synthase
kinetic law: 968231
reversible: true
reactant: 968195
notes: GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Nucleotides
fast: false
product: 968219
reactant: 968183

968207
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stoichiometry: 1.0
species: 866235

866235
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constant: false
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 7,8-Dihydrofolate

968280
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value: 0.0

968268
type: LocalParameter
value: 0.0

968256
type: LocalParameter
value: 1000.0

968243
type: LocalParameter
value: -1000.0

968195
type: SpeciesReference
stoichiometry: 1.0
species: 867734

968219
type: SpeciesReference
stoichiometry: 1.0
species: 866368

866368
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dTMP

968183
type: SpeciesReference
stoichiometry: 1.0
species: 866404

866404
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dUMP

905329
type: Reaction
kinetic law: 905414
product: 905402
name: ubiquinol-6 cytochrome c reductase, Complex III
reactant: 905365
reactant: 905341
fast: false
reversible: false
notes: GENE_ASSOCIATION: ((NM_013387.3 and NM_001916.2 and MT4519 and NM_006830.2 and NM_006294.2 and NM_003365.2 and NM_003366.2 and NM_006003.1 and NM_006004.2 and NM_014402.3) or (NM_001003684.1 and NM_001916.2 and MT4519 and NM_006830.2 and NM_006294.2 and NM_003365.2 and NM_003366.2 and NM_006003.1 and NM_006004.2 and NM_014402.3)) GENE_LIST: MT4519 NM_001003684.1 NM_001916.2 NM_003365.2 NM_003366.2 NM_006003.1 NM_006004.2 NM_006294.2 NM_006830.2 NM_013387.3 NM_014402.3 SUBSYSTEM: Oxidative Phosphorylation
reactant: 905353
product: 905377
product: 905389

905462
type: LocalParameter
value: 500.0

905450
type: LocalParameter
value: 0.0

905438
type: LocalParameter
value: 1000.0

905426
type: LocalParameter
value: 0.0

905402
type: SpeciesReference
stoichiometry: 1.0
species: 871130

905365
type: SpeciesReference
stoichiometry: 1.0
species: 870923

905341
type: SpeciesReference
stoichiometry: 2.0
species: 869981

869981
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ferricytochrome c

905353
type: SpeciesReference
stoichiometry: 2.0
species: 870140

905377
type: SpeciesReference
stoichiometry: 4.0
species: 867216

905389
type: SpeciesReference
stoichiometry: 2.0
species: 869993

869993
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ferrocytochrome c

886941
type: Reaction
reactant: 886979
kinetic law: 887027
reactant: 886967
reactant: 886954
product: 887003
fast: false
name: 5-aminolevulinate synthase
reversible: false
product: 886991
notes: GENE_ASSOCIATION: (NM_001037967.1 or NM_000032.2 or NM_001037968.1 or NM_001037969.1 or NM_000688.4 or NM_199166.1) GENE_LIST: NM_000032.2 NM_000688.4 NM_001037967.1 NM_001037968.1 NM_001037969.1 NM_199166.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 887015

886979
type: SpeciesReference
stoichiometry: 1.0
species: 870996

887075
type: LocalParameter
value: 500.0

887063
type: LocalParameter
value: 0.0

887051
type: LocalParameter
value: 1000.0

887039
type: LocalParameter
value: 0.0

886967
type: SpeciesReference
stoichiometry: 1.0
species: 870140

886954
type: SpeciesReference
stoichiometry: 1.0
species: 870104

870104
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Glycine

887003
type: SpeciesReference
stoichiometry: 1.0
species: 869631

886991
type: SpeciesReference
stoichiometry: 1.0
species: 869339

887015
type: SpeciesReference
stoichiometry: 1.0
species: 869643

959668
type: Reaction
kinetic law: 959764
product: 959752
name: phosphopantothenate-cysteine ligase
reversible: false
product: 959716
product: 959728
product: 959740
notes: GENE_ASSOCIATION: (NM_024664.2 or NM_001077447.1) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
reactant: 959692
reactant: 959704
reactant: 959680
fast: false

959812
type: LocalParameter
value: 500.0

959800
type: LocalParameter
value: 0.0

959788
type: LocalParameter
value: 1000.0

959776
type: LocalParameter
value: 0.0

959752
type: SpeciesReference
stoichiometry: 1.0
species: 868265

959716
type: SpeciesReference
stoichiometry: 1.0
species: 865218

959728
type: SpeciesReference
stoichiometry: 1.0
species: 865701

865701
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: CDP

959740
type: SpeciesReference
stoichiometry: 1.0
species: 867216

959692
type: SpeciesReference
stoichiometry: 1.0
species: 865919

959704
type: SpeciesReference
stoichiometry: 1.0
species: 865931

959680
type: SpeciesReference
stoichiometry: 1.0
species: 865206

865206
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-4'-Phosphopantothenate

912368
type: Reaction
kinetic law: 912404
product: 912392
reactant: 912380
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: eicosanoate transport (n-C20:0), cytosol to blood

912453
type: LocalParameter
value: 0.0

912440
type: LocalParameter
value: 0.0

912428
type: LocalParameter
value: 1000.0

912416
type: LocalParameter
value: -1000.0

912392
type: SpeciesReference
stoichiometry: 1.0
species: 866452

912380
type: SpeciesReference
stoichiometry: 1.0
species: 864212

864212
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Eicosanoate (n-C20:0)

879989
type: Reaction
kinetic law: 880026
product: 880013
reactant: 880001
fast: false
reversible: true
name: L-Tyrosine exchange

880076
type: LocalParameter
value: 500.0

880064
type: LocalParameter
value: 0.0

880052
type: LocalParameter
value: 1000.0

880039
type: LocalParameter
value: 0.0

880013
type: SpeciesReference
stoichiometry: 1.0
species: 872828

872828
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: tyr_L_b

880001
type: SpeciesReference
stoichiometry: 1.0
species: 864844

869933
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)

901922
type: Reaction
reversible: true
fast: false
product: 901958
reactant: 901946
name: carnitine ocosatetraenoyltransferase (C22:4Crn, n6)
kinetic law: 901982
product: 901970
reactant: 901934
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_152247.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle

901958
type: SpeciesReference
stoichiometry: 1.0
species: 865883

901946
type: SpeciesReference
stoichiometry: 1.0
species: 868109

902030
type: LocalParameter
value: 0.0

902018
type: LocalParameter
value: 0.0

902006
type: LocalParameter
value: 1000.0

901994
type: LocalParameter
value: -1000.0

901970
type: SpeciesReference
stoichiometry: 1.0
species: 868121

868121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ocosatetraenoyl carnitine (C22:4Crn, n-6)

901934
type: SpeciesReference
stoichiometry: 1.0
species: 865907

871713
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA(S)

866610
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosapentaenoyl-CoA (C20:5CoA, n-3)

865170
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 4-Imidazolone-5-propanoate

932344
type: Reaction
product: 932392
product: 932380
reactant: 932356
kinetic law: 932404
reactant: 932368
notes: GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Proline Biosynthesis
name: glutamate 5-kinase, mitochondrial
fast: false
reversible: false

932392
type: SpeciesReference
stoichiometry: 1.0
species: 870067

870067
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Glutamate 5-phosphate

932380
type: SpeciesReference
stoichiometry: 1.0
species: 869436

932356
type: SpeciesReference
stoichiometry: 1.0
species: 869509

932452
type: LocalParameter
value: 500.0

932440
type: LocalParameter
value: 0.0

932428
type: LocalParameter
value: 1000.0

932416
type: LocalParameter
value: 0.0

932368
type: SpeciesReference
stoichiometry: 1.0
species: 870055

952176
type: Reaction
reactant: 952188
kinetic law: 952236
product: 952212
fast: false
notes: GENE_ASSOCIATION: (NM_000436.2 or NM_022120.1) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
name: 3-oxoacid CoA-transferase
reversible: true
product: 952224
reactant: 952200

952188
type: SpeciesReference
stoichiometry: 1.0
species: 869400

952284
type: LocalParameter
value: 0.0

952272
type: LocalParameter
value: 0.0

952260
type: LocalParameter
value: 1000.0

952248
type: LocalParameter
value: -1000.0

952212
type: SpeciesReference
stoichiometry: 1.0
species: 869364

952224
type: SpeciesReference
stoichiometry: 1.0
species: 870984

952200
type: SpeciesReference
stoichiometry: 1.0
species: 870996

869583
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Citrate

872134
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: cys_L_b

881453
type: Reaction
product: 881502
product: 881526
reactant: 881465
name: L-aminoadipate-semialdehyde dehydrogenase (NADH), mitochondrial
reactant: 881490
reversible: false
fast: false
kinetic law: 881538
reactant: 881477
notes: GENE_ASSOCIATION: NM_001182.2 GENE_LIST: NM_001182.2 SUBSYSTEM: Lysine Degradation
product: 881514

881502
type: SpeciesReference
stoichiometry: 1.0
species: 869097

869097
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-2-Aminoadipate

881526
type: SpeciesReference
stoichiometry: 1.0
species: 870461

881465
type: SpeciesReference
stoichiometry: 1.0
species: 869485

881490
type: SpeciesReference
stoichiometry: 1.0
species: 870448

881587
type: LocalParameter
value: 500.0

881575
type: LocalParameter
value: 0.0

881563
type: LocalParameter
value: 1000.0

881551
type: LocalParameter
value: 0.0

881477
type: SpeciesReference
stoichiometry: 1.0
species: 870152

881514
type: SpeciesReference
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species: 870140

867940
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecadienoate (C18:2, n-6)

871215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 4-Methylzymosterol intermediate 2

872086
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: asp_L_b

919167
type: Reaction
reactant: 919179
product: 919264
product: 919276
reversible: false
kinetic law: 919300
name: Beta oxidation of long chain fatty acid
product: 919240
reactant: 919215
product: 919252
reactant: 919191
reactant: 919203
fast: false
product: 919288
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004... GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 919228

919179
type: SpeciesReference
stoichiometry: 1.0
species: 869643

919264
type: SpeciesReference
stoichiometry: 1.0
species: 869957

919276
type: SpeciesReference
stoichiometry: 1.0
species: 870140

919348
type: LocalParameter
value: 500.0

919336
type: LocalParameter
value: 0.0

919324
type: LocalParameter
value: 1000.0

919312
type: LocalParameter
value: 0.0

919240
type: SpeciesReference
stoichiometry: 1.0
species: 869412

919215
type: SpeciesReference
stoichiometry: 1.0
species: 870448

919252
type: SpeciesReference
stoichiometry: 1.0
species: 869691

919191
type: SpeciesReference
stoichiometry: 1.0
species: 869945

919203
type: SpeciesReference
stoichiometry: 1.0
species: 870152

919288
type: SpeciesReference
stoichiometry: 1.0
species: 870461

919228
type: SpeciesReference
stoichiometry: 1.0
species: 871021

864248
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosatrienoate (C20:3, n-6)

920495
type: Reaction
reactant: 920531
product: 920567
fast: false
reactant: 920555
reactant: 920519
reversible: false
product: 920591
name: Beta oxidation of fatty acid
reactant: 920507
reactant: 920543
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_014049.3 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001919.2 and (NM_000182.3 and NM_000... GENE_LIST: NM_000... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 920579
kinetic law: 920615
product: 920603

920531
type: SpeciesReference
stoichiometry: 8.0
species: 870152

920567
type: SpeciesReference
stoichiometry: 9.0
species: 869412

920555
type: SpeciesReference
stoichiometry: 1.0
species: 870647

920519
type: SpeciesReference
stoichiometry: 7.0
species: 869945

920591
type: SpeciesReference
stoichiometry: 8.0
species: 870140

920507
type: SpeciesReference
stoichiometry: 8.0
species: 869643

920543
type: SpeciesReference
stoichiometry: 8.0
species: 870448

920579
type: SpeciesReference
stoichiometry: 7.0
species: 869957

920663
type: LocalParameter
value: 500.0

920651
type: LocalParameter
value: 0.0

920639
type: LocalParameter
value: 1000.0

920627
type: LocalParameter
value: 0.0

920603
type: SpeciesReference
stoichiometry: 8.0
species: 870461

913059
type: Reaction
kinetic law: 913097
product: 913084
reactant: 913071
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ethanol transport in/out via diffusion

913145
type: LocalParameter
value: 0.0

913133
type: LocalParameter
value: 0.0

913121
type: LocalParameter
value: 1000.0

913109
type: LocalParameter
value: -1000.0

913084
type: SpeciesReference
stoichiometry: 1.0
species: 864296

913071
type: SpeciesReference
stoichiometry: 1.0
species: 866683

919360
type: Reaction
product: 919456
product: 919444
fast: false
product: 919468
reversible: false
reactant: 919420
name: Beta oxidation of fatty acid
kinetic law: 919480
reactant: 919384
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_014049.3 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_... GENE_LIST: NM_... NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 919408
reactant: 919372
reactant: 919396
product: 919432

919456
type: SpeciesReference
stoichiometry: 6.0
species: 870140

919444
type: SpeciesReference
stoichiometry: 5.0
species: 869957

919468
type: SpeciesReference
stoichiometry: 6.0
species: 870461

919420
type: SpeciesReference
stoichiometry: 1.0
species: 871046

871046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: tetradecenoyl-CoA (C14:1CoA, n-7)

919529
type: LocalParameter
value: 500.0

919516
type: LocalParameter
value: 0.0

919504
type: LocalParameter
value: 1000.0

919492
type: LocalParameter
value: 0.0

919384
type: SpeciesReference
stoichiometry: 5.0
species: 869945

919408
type: SpeciesReference
stoichiometry: 6.0
species: 870448

919372
type: SpeciesReference
stoichiometry: 6.0
species: 869643

919396
type: SpeciesReference
stoichiometry: 6.0
species: 870152

919432
type: SpeciesReference
stoichiometry: 7.0
species: 869412

871251
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 7-Dehydrocholesterol

872206
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ecsea9_b

924558
type: Reaction
product: 924630
product: 924666
reversible: false
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
fast: false
product: 924642
reactant: 924594
product: 924618
kinetic law: 924678
reactant: 924606
product: 924654
reactant: 924582
reactant: 924570
name: fatty acid synthase (n-C14:0)

924630
type: SpeciesReference
stoichiometry: 1.0
species: 865883

924666
type: SpeciesReference
stoichiometry: 1.0
species: 868854

868854
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: tetradecanoate (C14:0)

924642
type: SpeciesReference
stoichiometry: 1.0
species: 867228

924594
type: SpeciesReference
stoichiometry: 1.0
species: 867638

924618
type: SpeciesReference
stoichiometry: 1.0
species: 865871

924726
type: LocalParameter
value: 500.0

924714
type: LocalParameter
value: 0.0

924702
type: LocalParameter
value: 1000.0

924690
type: LocalParameter
value: 0.0

924606
type: SpeciesReference
stoichiometry: 2.0
species: 867830

924654
type: SpeciesReference
stoichiometry: 2.0
species: 867818

924582
type: SpeciesReference
stoichiometry: 3.0
species: 867216

924570
type: SpeciesReference
stoichiometry: 1.0
species: 866149

872459
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: hpdca_b

951888
type: Reaction
kinetic law: 951924
product: 951912
reactant: 951900
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecatrienoate (C18:3, n-3) transport

951972
type: LocalParameter
value: 0.0

951960
type: LocalParameter
value: 0.0

951948
type: LocalParameter
value: 1000.0

951936
type: LocalParameter
value: -1000.0

951912
type: SpeciesReference
stoichiometry: 1.0
species: 867915

867915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecatrienoate (C18:3, n-3)

951900
type: SpeciesReference
stoichiometry: 1.0
species: 864638

864638
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: octadecatrienoate (C18:3, n-3)

884224
type: Reaction
notes: GENE_ASSOCIATION: (NM_003051.3 or NM_004696.1 or NM_001042423.1 or NM_001042422.1 or NM_004207.1 or NM_004694.2 or NM_004731.3 or NM_013356.1 or NM_004695.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular
reactant: 884250
name: acetate transport in/out via proton symport
reversible: true
reactant: 884237
fast: false
product: 884276
kinetic law: 884289
product: 884263

884250
type: SpeciesReference
stoichiometry: 1.0
species: 864405

884237
type: SpeciesReference
stoichiometry: 1.0
species: 864041

864041
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Acetate

884276
type: SpeciesReference
stoichiometry: 1.0
species: 867216

884340
type: LocalParameter
value: 0.0

884328
type: LocalParameter
value: 0.0

884315
type: LocalParameter
value: 1000.0

884302
type: LocalParameter
value: -1000.0

884263
type: SpeciesReference
stoichiometry: 1.0
species: 865375

947897
type: Reaction
kinetic law: 947957
notes: SUBSYSTEM: Vitamins & Cofactor Biosynthesis
reactant: 947909
reactant: 947921
name: methylenetetrahydrofolate dehydrogenase (NADP)
reversible: true
product: 947933
product: 947945
fast: false

948006
type: LocalParameter
value: 0.0

947994
type: LocalParameter
value: 0.0

947981
type: LocalParameter
value: 1000.0

947969
type: LocalParameter
value: -1000.0

947909
type: SpeciesReference
stoichiometry: 1.0
species: 867734

947921
type: SpeciesReference
stoichiometry: 1.0
species: 867818

947933
type: SpeciesReference
stoichiometry: 1.0
species: 867698

867698
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5,10-Methenyltetrahydrofolate

947945
type: SpeciesReference
stoichiometry: 1.0
species: 867830

948272
type: Reaction
product: 948320
fast: false
notes: GENE_ASSOCIATION: ((NM_018838.3 and NM_015965.3 and MT4535 and MT4536 and MT4537 and MT4538 and MT4539 and MT4540 and MT4541 and NM_004541.2 and NM_004544.2 and NM_175614.2 and NM_002488.2 and NM_004542.1 and NM_002489.2 and NM_005000.2 and NM_002490.3 and NM_005001.1 and NM_014222.2 and NM_005002.3 and NM_005003.2 and NM_004545.3 and NM_004548.1 and NM_019056.2 and NM_004546.2 and NM_002491.1 and NM_004547.4 and NM_002492.2 and NM_182739.1 and NM_004146.4 and NM_005004.2 and NM_005005.1 and NM_002494.2 and NM_004549.3 and NM_005006.5 and NM_004550.3 and NM_004551.1 and NM_002495.1 and NM_004552.1 and NM_004553.3 and NM_024407.3 and NM_002496.1 and NM_007103.2 and NM_021074.1 and NM_021075.3) or (NM_018838.3 and NM_015965.3 and MT4535 and MT4536 and MT4537 and MT4538 and MT4539 and MT4540 and MT4541 and NM_004541.2 and NM_004544.2 and NM_175614.2 and NM_002488.2 and NM_004542.1 and N... GENE_LIST: MT4535 MT4536 MT4537 MT4538 MT4539 MT4540 MT4541 N... NM_002488.2 NM_002489.2 NM_002490.3 NM_002491.1 NM_002492.2 NM_002494.2 NM_002495.1 NM_002496.1 NM_004146.4 NM_004541.2 NM_004542.1 NM_004544.2 NM_004545.3 NM_004546.2 NM_004547.4 NM_004548.1 NM_004549.3 NM_004550.3 NM_004551.1 NM_004552.1 NM_004553.3 NM_005000.2 NM_005001.1 NM_005002.3 NM_005003.2 NM_005004.2 NM_005005.1 NM_005006.5 NM_007103.2 NM_014222.2 NM_015965.3 NM_018838.3 NM_019056.2 NM_021074.1 NM_021075.3 NM_024407.3 NM_175614.2 NM_182739.1 SUBSYSTEM: Oxidative Phosphorylation
reactant: 948308
product: 948332
reactant: 948284
reactant: 948296
kinetic law: 948356
reversible: false
name: NADH dehydrogenase, mitochondrial
product: 948344

948320
type: SpeciesReference
stoichiometry: 4.0
species: 867216

948308
type: SpeciesReference
stoichiometry: 1.0
species: 871130

948332
type: SpeciesReference
stoichiometry: 1.0
species: 870448

948284
type: SpeciesReference
stoichiometry: 5.0
species: 870140

948296
type: SpeciesReference
stoichiometry: 1.0
species: 870461

948404
type: LocalParameter
value: 500.0

948392
type: LocalParameter
value: 0.0

948380
type: LocalParameter
value: 1000.0

948368
type: LocalParameter
value: 0.0

948344
type: SpeciesReference
stoichiometry: 1.0
species: 870923

921216
type: Reaction
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 921288
product: 921325
name: Beta oxidation of long chain fatty acid
reactant: 921276
product: 921337
reversible: false
reactant: 921240
product: 921300
kinetic law: 921349
reactant: 921228
product: 921312
fast: false
reactant: 921264
reactant: 921252

921288
type: SpeciesReference
stoichiometry: 1.0
species: 869412

921325
type: SpeciesReference
stoichiometry: 1.0
species: 870461

921276
type: SpeciesReference
stoichiometry: 1.0
species: 870448

921337
type: SpeciesReference
stoichiometry: 1.0
species: 870960

870960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Stearyl-CoA (n-C18:0CoA)

921240
type: SpeciesReference
stoichiometry: 1.0
species: 869787

921300
type: SpeciesReference
stoichiometry: 1.0
species: 869957

921397
type: LocalParameter
value: 500.0

921385
type: LocalParameter
value: 0.0

921373
type: LocalParameter
value: 1000.0

921361
type: LocalParameter
value: 0.0

921228
type: SpeciesReference
stoichiometry: 1.0
species: 869643

921312
type: SpeciesReference
stoichiometry: 1.0
species: 870140

921264
type: SpeciesReference
stoichiometry: 1.0
species: 870152

921252
type: SpeciesReference
stoichiometry: 1.0
species: 869945

919927
type: Reaction
product: 920024
reactant: 919988
kinetic law: 920049
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_001127328.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and N... GENE_LIST: N... NM_000016.2 NM_000018.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 919940
reversible: false
name: Beta oxidation of fatty acid
product: 920012
product: 920000
fast: false
reactant: 919964
reactant: 919952
reactant: 919976
product: 920036

920024
type: SpeciesReference
stoichiometry: 7.0
species: 870140

919988
type: SpeciesReference
stoichiometry: 7.0
species: 870448

920097
type: LocalParameter
value: 500.0

920085
type: LocalParameter
value: 0.0

920073
type: LocalParameter
value: 1000.0

920061
type: LocalParameter
value: 0.0

919940
type: SpeciesReference
stoichiometry: 7.0
species: 869643

920012
type: SpeciesReference
stoichiometry: 6.0
species: 869957

920000
type: SpeciesReference
stoichiometry: 8.0
species: 869412

919964
type: SpeciesReference
stoichiometry: 7.0
species: 870152

919952
type: SpeciesReference
stoichiometry: 6.0
species: 869945

919976
type: SpeciesReference
stoichiometry: 1.0
species: 870188

870188
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: hexadecenoyl-CoA (C16:1CoA, n-7)

920036
type: SpeciesReference
stoichiometry: 7.0
species: 870461

907371
type: Reaction
fast: false
notes: GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Biosynthesis
reversible: true
product: 907420
product: 907432
reactant: 907383
reactant: 907407
name: CDP-Diacylglycerol synthetase, human hepatocyte
kinetic law: 907444
reactant: 907395

907420
type: SpeciesReference
stoichiometry: 0.001
species: 865725

907432
type: SpeciesReference
stoichiometry: 1.0
species: 868361

907383
type: SpeciesReference
stoichiometry: 1.0
species: 865919

907407
type: SpeciesReference
stoichiometry: 0.001
species: 868133

907493
type: LocalParameter
value: 0.0

907480
type: LocalParameter
value: 0.0

907468
type: LocalParameter
value: 1000.0

907456
type: LocalParameter
value: -1000.0

907395
type: SpeciesReference
stoichiometry: 1.0
species: 867216

870116
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: sn-Glycerol 3-phosphate

870212
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-3-Hydroxyisobutyryl-CoA

899635
type: Reaction
reactant: 899659
reactant: 899647
name: eicosanoyl carnitine transport (C20:0Crn)
fast: false
product: 899671
kinetic law: 899695
product: 899683
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

899659
type: SpeciesReference
stoichiometry: 1.0
species: 869655

899647
type: SpeciesReference
stoichiometry: 1.0
species: 866476

866476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosanoylcarnitine, C20:0crn

899671
type: SpeciesReference
stoichiometry: 1.0
species: 865907

899743
type: LocalParameter
value: 0.0

899731
type: LocalParameter
value: 0.0

899719
type: LocalParameter
value: 1000.0

899707
type: LocalParameter
value: -1000.0

899683
type: SpeciesReference
stoichiometry: 1.0
species: 869800

915620
type: Reaction
reversible: true
reactant: 915632
fast: false
reactant: 915644
product: 915680
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_001995.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
product: 915668
reactant: 915656
name: fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-9)
product: 915692
kinetic law: 915704

915632
type: SpeciesReference
stoichiometry: 1.0
species: 865641

915644
type: SpeciesReference
stoichiometry: 1.0
species: 865883

915680
type: SpeciesReference
stoichiometry: 1.0
species: 866647

915668
type: SpeciesReference
stoichiometry: 1.0
species: 865568

915656
type: SpeciesReference
stoichiometry: 1.0
species: 866536

866536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatrienoate (C20:3,n-9)

915692
type: SpeciesReference
stoichiometry: 1.0
species: 868361

915753
type: LocalParameter
value: 0.0

915741
type: LocalParameter
value: 0.0

915728
type: LocalParameter
value: 1000.0

915716
type: LocalParameter
value: -1000.0

872266
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ecsttea6_b

950128
type: Reaction
kinetic law: 950164
product: 950152
reactant: 950140
notes: GENE_ASSOCIATION: (NM_016321.1 or NM_000324.1 or NM_020407.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ammonium transport via diffusion

950212
type: LocalParameter
value: 0.0

950200
type: LocalParameter
value: 0.0

950188
type: LocalParameter
value: 1000.0

950176
type: LocalParameter
value: -1000.0

950152
type: SpeciesReference
stoichiometry: 1.0
species: 867842

950140
type: SpeciesReference
stoichiometry: 1.0
species: 864589

864589
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Ammonium

865713
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: CDPcholine

951984
type: Reaction
kinetic law: 952020
product: 952008
reactant: 951996
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecatrienoate (C18:3, n-6) transport

952068
type: LocalParameter
value: 0.0

952056
type: LocalParameter
value: 0.0

952044
type: LocalParameter
value: 1000.0

952032
type: LocalParameter
value: -1000.0

952008
type: SpeciesReference
stoichiometry: 1.0
species: 867928

867928
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecatrienoate (C18:3, n-6)

951996
type: SpeciesReference
stoichiometry: 1.0
species: 864650

951371
type: Reaction
kinetic law: 951407
product: 951395
reactant: 951383
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: O2 transport, peroxisomal

951455
type: LocalParameter
value: 0.0

951443
type: LocalParameter
value: 0.0

951431
type: LocalParameter
value: 1000.0

951419
type: LocalParameter
value: -1000.0

951395
type: SpeciesReference
stoichiometry: 1.0
species: 871905

871905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: O2

951383
type: SpeciesReference
stoichiometry: 1.0
species: 867854

907119
type: Reaction
product: 907179
kinetic law: 907191
reactant: 907131
product: 907167
reversible: false
notes: GENE_ASSOCIATION: (NM_003646.2 or NM_145695.1 or NM_001080744.1 or NM_004080.1 or NM_003648.2 or NM_001080745.1 or NM_152879.2 or NM_001347.2 or NM_201445.1 or NM_001013742.1 or NM_201533.1 or NM_001346.2 or NM_003647.1 or NM_201532.1 or NM_004717.2 or NM_201444.2 or NM_152910.3 or NM_001345.4 or NM_201554.1 or NM_001105540.1 or NM_178009.2) GENE_LIST: NM_001013742.1 NM_001080744.1 NM_001080745.1 NM_001105540.1 NM_001345.4 NM_001346.2 NM_001347.2 NM_003646.2 NM_003647.1 NM_003648.2 NM_004080.1 NM_004717.2 NM_145695.1 NM_152879.2 NM_152910.3 NM_178009.2 NM_201444.2 NM_201445.1 NM_201532.1 NM_201533.1 NM_201554.1 SUBSYSTEM: Phospholipid Metabolism
name: diacylglycerol kinase
reactant: 907143
product: 907155
fast: false

907179
type: SpeciesReference
stoichiometry: 0.001
species: 868133

907239
type: LocalParameter
value: 500.0

907227
type: LocalParameter
value: 0.0

907215
type: LocalParameter
value: 1000.0

907203
type: LocalParameter
value: 0.0

907131
type: SpeciesReference
stoichiometry: 0.001
species: 864893

907167
type: SpeciesReference
stoichiometry: 1.0
species: 867216

907143
type: SpeciesReference
stoichiometry: 1.0
species: 865641

907155
type: SpeciesReference
stoichiometry: 1.0
species: 865460

950321
type: Reaction
product: 950369
product: 950357
kinetic law: 950381
name: 5'-nucleotidase (dUMP)
fast: false
reactant: 950333
reactant: 950345
reversible: false
notes: GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Pyrimidine Catabolism

950369
type: SpeciesReference
stoichiometry: 1.0
species: 868265

950357
type: SpeciesReference
stoichiometry: 1.0
species: 866416

866416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Deoxyuridine

950431
type: LocalParameter
value: 500.0

950419
type: LocalParameter
value: 0.0

950406
type: LocalParameter
value: 1000.0

950394
type: LocalParameter
value: 0.0

950333
type: SpeciesReference
stoichiometry: 1.0
species: 866404

950345
type: SpeciesReference
stoichiometry: 1.0
species: 867228

865665
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: cAMP

950006
type: Reaction
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018137.1) or (NM_000269.2 and NM_001018139.1) or (NM_002512.2 and NM_198175.1) or NM_005793.3 or (NM_001018139.1 and NM_198175.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018138.1) or NM_002513.2 or NM_197972.1 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or NM_013330.3) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Pyrimidine Metabolism
reactant: 950018
name: nucleoside-diphophate kinase (ATP:IDP)
product: 950055
kinetic law: 950068
fast: false
reversible: true
reactant: 950030
product: 950042

950018
type: SpeciesReference
stoichiometry: 1.0
species: 865641

950055
type: SpeciesReference
stoichiometry: 1.0
species: 867541

867541
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: ITP

950116
type: LocalParameter
value: 0.0

950104
type: LocalParameter
value: 0.0

950092
type: LocalParameter
value: 1000.0

950080
type: LocalParameter
value: -1000.0

950030
type: SpeciesReference
stoichiometry: 1.0
species: 867456

950042
type: SpeciesReference
stoichiometry: 1.0
species: 865460

888937
type: Reaction
kinetic law: 888985
product: 888973
product: 888961
reactant: 888949
notes: GENE_ASSOCIATION: (NM_001024946.1 or NM_001024943.1 or NM_001024944.1 or NM_000048.3) GENE_LIST: NM_000048.3 NM_001024943.1 NM_001024944.1 NM_001024946.1 SUBSYSTEM: Urea Cycle
fast: false
reversible: true
name: argininosuccinate lyase

889033
type: LocalParameter
value: 0.0

889021
type: LocalParameter
value: 0.0

889009
type: LocalParameter
value: 1000.0

888997
type: LocalParameter
value: -1000.0

888973
type: SpeciesReference
stoichiometry: 1.0
species: 866924

888961
type: SpeciesReference
stoichiometry: 1.0
species: 865593

888949
type: SpeciesReference
stoichiometry: 1.0
species: 865605

865605
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N(omega)-(L-Arginino)succinate

918297
type: Reaction
kinetic law: 918333
product: 918321
reactant: 918309
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: formaldehyde transport, peroxisomal

918381
type: LocalParameter
value: 0.0

918369
type: LocalParameter
value: 0.0

918357
type: LocalParameter
value: 1000.0

918345
type: LocalParameter
value: -1000.0

918321
type: SpeciesReference
stoichiometry: 1.0
species: 871797

871797
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Formaldehyde

918309
type: SpeciesReference
stoichiometry: 1.0
species: 866792

957135
type: Reaction
reactant: 957159
kinetic law: 957207
notes: GENE_ASSOCIATION: NM_006319.3 GENE_LIST: NM_006319.3 SUBSYSTEM: Phospholipid Biosynthesis
product: 957195
name: phosphatidylinositol synthase, human hepatocyte
product: 957183
reactant: 957147
fast: false
product: 957171
reversible: true

957159
type: SpeciesReference
stoichiometry: 1.0
species: 867516

867516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: myo-Inositol

957255
type: LocalParameter
value: 0.0

957243
type: LocalParameter
value: 0.0

957231
type: LocalParameter
value: 1000.0

957219
type: LocalParameter
value: -1000.0

957195
type: SpeciesReference
stoichiometry: 0.001
species: 868277

957183
type: SpeciesReference
stoichiometry: 1.0
species: 867216

957147
type: SpeciesReference
stoichiometry: 0.001
species: 865725

957171
type: SpeciesReference
stoichiometry: 1.0
species: 865859

865859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: CMP

897092
type: Reaction
product: 897140
kinetic law: 897152
name: carnitine docosapentaenoyltransferase (C22:5Crn, n6)
reactant: 897116
fast: false
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_152247.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
reactant: 897104
product: 897128

897140
type: SpeciesReference
stoichiometry: 1.0
species: 866344

866344
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoyl carnitine (C22:5Crn, n-6)

897201
type: LocalParameter
value: 0.0

897189
type: LocalParameter
value: 0.0

897177
type: LocalParameter
value: 1000.0

897164
type: LocalParameter
value: -1000.0

897116
type: SpeciesReference
stoichiometry: 1.0
species: 866319

866319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoyl-CoA (C22:5CoA, n-6)

897104
type: SpeciesReference
stoichiometry: 1.0
species: 865907

897128
type: SpeciesReference
stoichiometry: 1.0
species: 865883

864929
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 1-Acyl-sn-glycero-3-phosphocholine

923617
type: Reaction
kinetic law: 923750
reactant: 923654
reversible: false
reactant: 923630
reactant: 923642
product: 923690
product: 923702
product: 923738
reactant: 923678
product: 923714
name: Beta oxidation of odd chain fatty acid
reactant: 923666
fast: false
product: 923726
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation

923798
type: LocalParameter
value: 500.0

923786
type: LocalParameter
value: 0.0

923774
type: LocalParameter
value: 1000.0

923762
type: LocalParameter
value: 0.0

923654
type: SpeciesReference
stoichiometry: 1.0
species: 870152

923630
type: SpeciesReference
stoichiometry: 1.0
species: 869643

923642
type: SpeciesReference
stoichiometry: 1.0
species: 869945

923690
type: SpeciesReference
stoichiometry: 1.0
species: 869412

923702
type: SpeciesReference
stoichiometry: 1.0
species: 869957

923738
type: SpeciesReference
stoichiometry: 1.0
species: 870899

870899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Pentanoyl-CoA (C5:0CoA)

923678
type: SpeciesReference
stoichiometry: 1.0
species: 870448

923714
type: SpeciesReference
stoichiometry: 1.0
species: 870140

923666
type: SpeciesReference
stoichiometry: 1.0
species: 870238

923726
type: SpeciesReference
stoichiometry: 1.0
species: 870461

871082
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

951696
type: Reaction
kinetic law: 951732
product: 951720
reactant: 951708
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecanoate (n-C18:0) transport in via uniport

951780
type: LocalParameter
value: 0.0

951768
type: LocalParameter
value: 0.0

951756
type: LocalParameter
value: 1000.0

951744
type: LocalParameter
value: -1000.0

951720
type: SpeciesReference
stoichiometry: 1.0
species: 864614

864614
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: octadecanoate (n-C18:0)

951708
type: SpeciesReference
stoichiometry: 1.0
species: 867891

866622
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosapentaenoyl carnitine (C20:5Crn, n-3)

962519
type: Reaction
reactant: 962531
product: 962555
name: ribonucleoside-diphosphate reductase (ADP)
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotides
reversible: false
product: 962579
product: 962567
reactant: 962543
kinetic law: 962591
fast: false

962531
type: SpeciesReference
stoichiometry: 1.0
species: 865460

962555
type: SpeciesReference
stoichiometry: 1.0
species: 865979

865979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dADP

962579
type: SpeciesReference
stoichiometry: 1.0
species: 868794

962567
type: SpeciesReference
stoichiometry: 1.0
species: 867228

962543
type: SpeciesReference
stoichiometry: 1.0
species: 868806

962639
type: LocalParameter
value: 500.0

962627
type: LocalParameter
value: 0.0

962615
type: LocalParameter
value: 1000.0

962603
type: LocalParameter
value: 0.0

881866
type: Reaction
name: acetyl-CoA C-acetyltransferase, mitochondrial
fast: false
product: 881903
product: 881915
kinetic law: 881927
notes: GENE_ASSOCIATION: NM_000019.2 GENE_LIST: NM_000019.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 881878
reactant: 881890
reversible: true

881903
type: SpeciesReference
stoichiometry: 1.0
species: 869412

881915
type: SpeciesReference
stoichiometry: 1.0
species: 870851

881975
type: LocalParameter
value: 0.0

881963
type: LocalParameter
value: 0.0

881951
type: LocalParameter
value: 1000.0

881939
type: LocalParameter
value: -1000.0

881878
type: SpeciesReference
stoichiometry: 1.0
species: 869121

881890
type: SpeciesReference
stoichiometry: 1.0
species: 869643

903730
type: Reaction
fast: false
reversible: true
product: 903778
name: carnitine tetradecenoyltransferase (C14:1Crn, n7), mitochondrial
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 903754
product: 903766
reactant: 903742
kinetic law: 903790

903778
type: SpeciesReference
stoichiometry: 1.0
species: 871058

871058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: tetradecenoyl carnitine (C14:1Crn, n-7)

903754
type: SpeciesReference
stoichiometry: 1.0
species: 871046

903766
type: SpeciesReference
stoichiometry: 1.0
species: 869643

903742
type: SpeciesReference
stoichiometry: 1.0
species: 869655

903838
type: LocalParameter
value: 0.0

903826
type: LocalParameter
value: 0.0

903814
type: LocalParameter
value: 1000.0

903802
type: LocalParameter
value: -1000.0

872351
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: glu_L_b

902284
type: Reaction
reactant: 902296
fast: false
product: 902333
reactant: 902308
reversible: true
name: carnitine octadecanoyltransferase (C18:0Crn)
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152359.1 or NM_001031847.1 or NM_004377.2 or NM_001876.2 or NM_152246.1 or NM_152247.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 902321
kinetic law: 902345

902296
type: SpeciesReference
stoichiometry: 1.0
species: 865907

902333
type: SpeciesReference
stoichiometry: 1.0
species: 868637

902308
type: SpeciesReference
stoichiometry: 1.0
species: 868625

868625
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Stearyl-CoA (n-C18:0CoA)

902321
type: SpeciesReference
stoichiometry: 1.0
species: 865883

902393
type: LocalParameter
value: 0.0

902381
type: LocalParameter
value: 0.0

902369
type: LocalParameter
value: 1000.0

902357
type: LocalParameter
value: -1000.0

870779
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Phosphatidylglycerophosphate, Hybridoma

903249
type: Reaction
kinetic law: 903309
reversible: true
reactant: 903273
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_001031847.1 or NM_152246.1 or NM_001876.2 or NM_152245.1 or NM_152247.1 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 903261
fast: false
product: 903297
name: carnitine O-palmitoyltransferase (C16:0Crn)
product: 903285

903357
type: LocalParameter
value: 0.0

903345
type: LocalParameter
value: 0.0

903333
type: LocalParameter
value: 1000.0

903321
type: LocalParameter
value: -1000.0

903273
type: SpeciesReference
stoichiometry: 1.0
species: 868289

868289
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Palmitoyl-CoA (n-C16:0CoA)

903261
type: SpeciesReference
stoichiometry: 1.0
species: 865907

903297
type: SpeciesReference
stoichiometry: 1.0
species: 868301

868301
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Palmitoylcarnitine (C16:0Crn)

903285
type: SpeciesReference
stoichiometry: 1.0
species: 865883

914314
type: Reaction
kinetic law: 914398
product: 914386
reactant: 914326
name: fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_022977.1 or NM_001009185.1 or NM_004458.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
reactant: 914350
reactant: 914338
product: 914374
reversible: true
product: 914362

914447
type: LocalParameter
value: 0.0

914434
type: LocalParameter
value: 0.0

914422
type: LocalParameter
value: 1000.0

914410
type: LocalParameter
value: -1000.0

914386
type: SpeciesReference
stoichiometry: 1.0
species: 868361

914326
type: SpeciesReference
stoichiometry: 1.0
species: 865641

914350
type: SpeciesReference
stoichiometry: 1.0
species: 867903

867903
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecenoate (C18:1, n-9)

914338
type: SpeciesReference
stoichiometry: 1.0
species: 865883

914374
type: SpeciesReference
stoichiometry: 1.0
species: 868048

914362
type: SpeciesReference
stoichiometry: 1.0
species: 865568

954161
type: Reaction
fast: false
name: 1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
product: 954209
reversible: false
kinetic law: 954245
product: 954233
reactant: 954185
reactant: 954197
product: 954221
reactant: 954173
notes: GENE_ASSOCIATION: (NM_170726.1 or NM_003748.2) GENE_LIST: NM_003748.2 NM_170726.1 SUBSYSTEM: Arginine and Proline Metabolism

954209
type: SpeciesReference
stoichiometry: 1.0
species: 870055

954294
type: LocalParameter
value: 500.0

954281
type: LocalParameter
value: 0.0

954269
type: LocalParameter
value: 1000.0

954257
type: LocalParameter
value: 0.0

954233
type: SpeciesReference
stoichiometry: 1.0
species: 870461

954185
type: SpeciesReference
stoichiometry: 2.0
species: 870152

954197
type: SpeciesReference
stoichiometry: 1.0
species: 870448

954221
type: SpeciesReference
stoichiometry: 1.0
species: 870140

954173
type: SpeciesReference
stoichiometry: 1.0
species: 869085

869085
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 1-Pyrroline-5-carboxylate

881600
type: Reaction
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
reactant: 881612
product: 881636
fast: false
reversible: true
notes: GENE_ASSOCIATION: (NM_020686.3 or NM_000663.2) GENE_LIST: NM_000663.2 NM_020686.3 SUBSYSTEM: Glutamate Metabolism
product: 881648
kinetic law: 881660
reactant: 881624

881612
type: SpeciesReference
stoichiometry: 1.0
species: 869315

869315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 4-Aminobutanoate

881636
type: SpeciesReference
stoichiometry: 1.0
species: 870055

881648
type: SpeciesReference
stoichiometry: 1.0
species: 871009

881709
type: LocalParameter
value: 0.0

881697
type: LocalParameter
value: 0.0

881684
type: LocalParameter
value: 1000.0

881672
type: LocalParameter
value: -1000.0

881624
type: SpeciesReference
stoichiometry: 1.0
species: 869448

907794
type: Reaction
fast: false
reactant: 907830
reactant: 907818
product: 907854
reactant: 907806
reversible: false
notes: GENE_ASSOCIATION: (NM_001921.2 or NM_001012732.1) GENE_LIST: NM_001012732.1 NM_001921.2 SUBSYSTEM: Pyrimidine Catabolism
name: dCMP deaminase
kinetic law: 907866
product: 907842

907830
type: SpeciesReference
stoichiometry: 1.0
species: 867228

907818
type: SpeciesReference
stoichiometry: 1.0
species: 867216

907854
type: SpeciesReference
stoichiometry: 1.0
species: 867842

907806
type: SpeciesReference
stoichiometry: 1.0
species: 866051

907914
type: LocalParameter
value: 500.0

907902
type: LocalParameter
value: 0.0

907890
type: LocalParameter
value: 1000.0

907878
type: LocalParameter
value: 0.0

907842
type: SpeciesReference
stoichiometry: 1.0
species: 866404

916198
type: Reaction
product: 916247
name: fatty-acid--CoA ligase (docosanoate, C22:0)
kinetic law: 916284
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
product: 916271
fast: false
reactant: 916223
reactant: 916235
reactant: 916211
reversible: true
product: 916259

916247
type: SpeciesReference
stoichiometry: 1.0
species: 865568

916334
type: LocalParameter
value: 0.0

916322
type: LocalParameter
value: 0.0

916309
type: LocalParameter
value: 1000.0

916296
type: LocalParameter
value: -1000.0

916271
type: SpeciesReference
stoichiometry: 1.0
species: 868361

916223
type: SpeciesReference
stoichiometry: 1.0
species: 865883

916235
type: SpeciesReference
stoichiometry: 1.0
species: 866064

916211
type: SpeciesReference
stoichiometry: 1.0
species: 865641

916259
type: SpeciesReference
stoichiometry: 1.0
species: 866076

866076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosanoyl-CoA (C22:0CoA)

879308
type: Reaction
kinetic law: 879345
product: 879333
reactant: 879320
fast: false
reversible: true
name: Pyruvate exchange

879394
type: LocalParameter
value: 500.0

879381
type: LocalParameter
value: 0.0

879369
type: LocalParameter
value: 1000.0

879357
type: LocalParameter
value: 0.0

879333
type: SpeciesReference
stoichiometry: 1.0
species: 872740

872740
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: pyr_b

879320
type: SpeciesReference
stoichiometry: 1.0
species: 864759

916054
type: Reaction
reactant: 916066
product: 916126
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_004458.1 or NM_203380.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
product: 916102
reactant: 916090
reversible: true
product: 916114
fast: false
name: fatty-acid--CoA ligase (eicosapentaenoate, C20:5 n-3)
kinetic law: 916138
reactant: 916078

916066
type: SpeciesReference
stoichiometry: 1.0
species: 865641

916126
type: SpeciesReference
stoichiometry: 1.0
species: 868361

916102
type: SpeciesReference
stoichiometry: 1.0
species: 865568

916090
type: SpeciesReference
stoichiometry: 1.0
species: 866512

866512
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosapentaenoate (C20:5, n-3)

916114
type: SpeciesReference
stoichiometry: 1.0
species: 866610

916186
type: LocalParameter
value: 0.0

916174
type: LocalParameter
value: 0.0

916162
type: LocalParameter
value: 1000.0

916150
type: LocalParameter
value: -1000.0

916078
type: SpeciesReference
stoichiometry: 1.0
species: 865883

876974
type: Reaction
kinetic law: 877011
product: 876999
reactant: 876987
fast: false
reversible: true
name: L-Histidine exchange

877059
type: LocalParameter
value: -0.00407468

877047
type: LocalParameter
value: 0.0

877035
type: LocalParameter
value: 0.0

877023
type: LocalParameter
value: -0.00814936

876999
type: SpeciesReference
stoichiometry: 1.0
species: 872447

872447
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: his_L_b

876987
type: SpeciesReference
stoichiometry: 1.0
species: 864466

864466
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Histidine

866586
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosenoyl-CoA (C20:1CoA, n-9)

888152
type: Reaction
kinetic law: 888237
reactant: 888177
reactant: 888189
notes: SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
product: 888201
reversible: false
name: Aldose reductase
product: 888225
product: 888213
reactant: 888164

888285
type: LocalParameter
value: 500.0

888273
type: LocalParameter
value: 0.0

888261
type: LocalParameter
value: 1000.0

888249
type: LocalParameter
value: 0.0

888177
type: SpeciesReference
stoichiometry: 1.0
species: 867770

867770
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Methylglyoxal

888189
type: SpeciesReference
stoichiometry: 1.0
species: 867818

888201
type: SpeciesReference
stoichiometry: 2.0
species: 867216

888225
type: SpeciesReference
stoichiometry: 1.0
species: 868493

888213
type: SpeciesReference
stoichiometry: 1.0
species: 867830

888164
type: SpeciesReference
stoichiometry: 1.0
species: 867228

872014
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: 3hbut_R_b

871239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 6-phospho-D-glucono-1,5-lactone

953259
type: Reaction
kinetic law: 953355
product: 953343
reactant: 953295
notes: GENE_ASSOCIATION: NM_000784.2 GENE_LIST: NM_000784.2 SUBSYSTEM: Bile Acid Biosynthesis
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
product: 953331
reactant: 953271
product: 953319
reversible: false
fast: false
reactant: 953283
reactant: 953307

953403
type: LocalParameter
value: 500.0

953391
type: LocalParameter
value: 0.0

953379
type: LocalParameter
value: 1000.0

953367
type: LocalParameter
value: 0.0

953343
type: SpeciesReference
stoichiometry: 1.0
species: 871154

953295
type: SpeciesReference
stoichiometry: 1.0
species: 870526

953331
type: SpeciesReference
stoichiometry: 1.0
species: 870474

953271
type: SpeciesReference
stoichiometry: 1.0
species: 870140

953319
type: SpeciesReference
stoichiometry: 1.0
species: 870152

953283
type: SpeciesReference
stoichiometry: 1.0
species: 870487

953307
type: SpeciesReference
stoichiometry: 1.0
species: 871166

871166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane

967553
type: Reaction
kinetic law: 967603
product: 967590
product: 967577
reactant: 967565
notes: GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false
reversible: false
name: L-threonine deaminase

967653
type: LocalParameter
value: 500.0

967640
type: LocalParameter
value: 0.0

967628
type: LocalParameter
value: 1000.0

967616
type: LocalParameter
value: 0.0

967590
type: SpeciesReference
stoichiometry: 1.0
species: 867842

967577
type: SpeciesReference
stoichiometry: 1.0
species: 864989

967565
type: SpeciesReference
stoichiometry: 1.0
species: 868770

923810
type: Reaction
product: 923895
product: 923883
reactant: 923823
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 923847
product: 923931
product: 923907
reactant: 923871
kinetic law: 923943
fast: false
product: 923919
reversible: false
name: Beta oxidation of fatty acid
reactant: 923835
reactant: 923859

923895
type: SpeciesReference
stoichiometry: 1.0
species: 869957

923883
type: SpeciesReference
stoichiometry: 1.0
species: 869412

923823
type: SpeciesReference
stoichiometry: 1.0
species: 869643

923847
type: SpeciesReference
stoichiometry: 1.0
species: 870152

923931
type: SpeciesReference
stoichiometry: 1.0
species: 870461

923907
type: SpeciesReference
stoichiometry: 1.0
species: 870140

923871
type: SpeciesReference
stoichiometry: 1.0
species: 870563

870563
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Octanoyl-CoA (C8:0CoA)

923991
type: LocalParameter
value: 500.0

923979
type: LocalParameter
value: 0.0

923967
type: LocalParameter
value: 1000.0

923955
type: LocalParameter
value: 0.0

923919
type: SpeciesReference
stoichiometry: 1.0
species: 870275

870275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Hexanoyl-CoA (C6:0CoA)

923835
type: SpeciesReference
stoichiometry: 1.0
species: 869945

923859
type: SpeciesReference
stoichiometry: 1.0
species: 870448

891076
type: Reaction
notes: GENE_ASSOCIATION: (((NM_022745.2 or NM_001042546) and NM_145691.3 and MT4509 and MT4508 and NM_001688.4 and (NM_001002027.1 or NM_005175.2) and (NM_006356.2 or NM_001003785.1) and NM_007100.2 and (NM_001003713.1 or NM_004889.2 or NM_001039178.1 or NM_001003714.1) and (NM_001003696.1 or NM_001003701.1 or NM_001003703.1 or NM_001685.4 or NM_001003697.1) and NM_006476.4 and (NM_015684.2 or NM_001003805.1 or NM_001003803.1) and NM_001697.2 and (NM_004046.4 or NM_001001937.1) and NM_001686.3 and (NM_001687.4 or NM_001001975.1) and (NM_006886.2 or NM_001001977.1) and (NM_001001973.1 or NM_005174.2)) or ((NM_022745.2 or NM_001042546) and NM_145691.3 and MT4509 and MT4508 and NM_001688.4 and (NM_005176.5 or NM_001002031.2) and (NM_006356.2 or NM_001003785.1) and NM_007100.2 and (NM_001003713.1 or NM_004889.2 or NM_001039178.1 or NM_001003714.1) and (NM_001003696.1 or NM_001003701.... GENE_LIST: MT4508 MT4509 NM_001001937.1 NM_001001973.1 NM_001001975.1 NM_001001977.1 NM_001002027.1 NM_001002031.2 NM_001003696.1 NM_001003697.1 NM_001003701.... NM_001003701.1 NM_001003703.1 NM_001003713.1 NM_001003714.1 NM_001003785.1 NM_001003803.1 NM_001003805.1 NM_001039178.1 NM_001042546 NM_001685.4 NM_001686.3 NM_001687.4 NM_001688.4 NM_001697.2 NM_004046.4 NM_004889.2 NM_005174.2 NM_005175.2 NM_005176.5 NM_006356.2 NM_006476.4 NM_006886.2 NM_007100.2 NM_015684.2 NM_022745.2 NM_145691.3 SUBSYSTEM: Oxidative Phosphorylation
fast: false
reactant: 891088
product: 891148
name: ATP synthase, mitochondrial
reactant: 891100
reversible: false
product: 891124
reactant: 891112
kinetic law: 891160
product: 891136

891088
type: SpeciesReference
stoichiometry: 4.0
species: 867216

891148
type: SpeciesReference
stoichiometry: 1.0
species: 870152

891100
type: SpeciesReference
stoichiometry: 1.0
species: 869436

891124
type: SpeciesReference
stoichiometry: 1.0
species: 869509

891112
type: SpeciesReference
stoichiometry: 1.0
species: 870803

891209
type: LocalParameter
value: 500.0

891197
type: LocalParameter
value: 0.0

891185
type: LocalParameter
value: 1000.0

891172
type: LocalParameter
value: 0.0

891136
type: SpeciesReference
stoichiometry: 3.0
species: 870140

913737
type: Reaction
reversible: true
product: 913809
name: fatty-acid--CoA ligase (hexadecanoate)
fast: false
product: 913797
product: 913785
reactant: 913749
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reactant: 913773
kinetic law: 913821
reactant: 913761

913809
type: SpeciesReference
stoichiometry: 1.0
species: 868361

913797
type: SpeciesReference
stoichiometry: 1.0
species: 868289

913785
type: SpeciesReference
stoichiometry: 1.0
species: 865568

913749
type: SpeciesReference
stoichiometry: 1.0
species: 865641

913773
type: SpeciesReference
stoichiometry: 1.0
species: 867276

913869
type: LocalParameter
value: 0.0

913857
type: LocalParameter
value: 0.0

913845
type: LocalParameter
value: 1000.0

913833
type: LocalParameter
value: -1000.0

913761
type: SpeciesReference
stoichiometry: 1.0
species: 865883

881211
type: Reaction
reactant: 881235
product: 881259
fast: false
reactant: 881223
reactant: 881247
product: 881283
reversible: false
product: 881271
notes: GENE_ASSOCIATION: NM_003734.2 GENE_LIST: NM_003734.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
kinetic law: 881295
name: Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)

881235
type: SpeciesReference
stoichiometry: 1.0
species: 867228

881259
type: SpeciesReference
stoichiometry: 1.0
species: 867240

881223
type: SpeciesReference
stoichiometry: 1.0
species: 865363

865363
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Aminoacetone

881247
type: SpeciesReference
stoichiometry: 1.0
species: 867854

881283
type: SpeciesReference
stoichiometry: 1.0
species: 867842

881271
type: SpeciesReference
stoichiometry: 1.0
species: 867770

881345
type: LocalParameter
value: 500.0

881332
type: LocalParameter
value: 0.0

881320
type: LocalParameter
value: 1000.0

881308
type: LocalParameter
value: 0.0

872715
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: pro_L_b

865508
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole

898673
type: Reaction
reversible: true
product: 898721
reactant: 898697
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 898733
name: carnitine eicosatrienoyltransferase (C20:3Crn, n6)
product: 898709
reactant: 898685
fast: false

898721
type: SpeciesReference
stoichiometry: 1.0
species: 866659

866659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatrienoyl carnitine (C20:3Crn, n-6)

898697
type: SpeciesReference
stoichiometry: 1.0
species: 866635

898781
type: LocalParameter
value: 0.0

898769
type: LocalParameter
value: 0.0

898757
type: LocalParameter
value: 1000.0

898745
type: LocalParameter
value: -1000.0

898709
type: SpeciesReference
stoichiometry: 1.0
species: 865883

898685
type: SpeciesReference
stoichiometry: 1.0
species: 865907

894288
type: Reaction
name: Choline kinase
reactant: 894300
reactant: 894312
reversible: false
kinetic law: 894361
product: 894324
notes: GENE_ASSOCIATION: (NM_005198.3 or NM_001277.2 or NM_212469.1 or NM_152253.1) GENE_LIST: NM_001277.2 NM_005198.3 NM_152253.1 NM_212469.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
product: 894348
product: 894336

894300
type: SpeciesReference
stoichiometry: 1.0
species: 865641

894312
type: SpeciesReference
stoichiometry: 1.0
species: 865761

894410
type: LocalParameter
value: 500.0

894398
type: LocalParameter
value: 0.0

894385
type: LocalParameter
value: 1000.0

894373
type: LocalParameter
value: 0.0

894324
type: SpeciesReference
stoichiometry: 1.0
species: 865460

894348
type: SpeciesReference
stoichiometry: 1.0
species: 867216

894336
type: SpeciesReference
stoichiometry: 1.0
species: 865787

885402
type: Reaction
reversible: false
reactant: 885450
name: 1-Acyl-glycerol-3-phosphate acyltransferase, hepatocyte specific
reactant: 885498
reactant: 885657
reactant: 885621
reactant: 885523
reactant: 885573
product: 885705
reactant: 885426
reactant: 885597
reactant: 885486
reactant: 885462
reactant: 885548
reactant: 885560
kinetic law: 885717
product: 885693
reactant: 885669
reactant: 885645
reactant: 885414
reactant: 885438
fast: false
reactant: 885609
reactant: 885681
reactant: 885474
reactant: 885585
reactant: 885510
reactant: 885633
reactant: 885535
notes: GENE_ASSOCIATION: (NM_178819.2 or NM_182551.3 or NM_018361.3 or NM_001012727.1 or NM_006412.3 or NM_001037553.1 or NM_032741.3 or NM_001002257.1 or NM_006411.2 or NM_153613.2 or NM_020133.2 or NM_020132.4) GENE_LIST: NM_001002257.1 NM_001012727.1 NM_001037553.1 NM_006411.2 NM_006412.3 NM_018361.3 NM_020132.4 NM_020133.2 NM_032741.3 NM_153613.2 NM_178819.2 NM_182551.3 SUBSYSTEM: Phospholipid Biosynthesis

885450
type: SpeciesReference
stoichiometry: 0.002
species: 866307

885498
type: SpeciesReference
stoichiometry: 0.001
species: 866610

885657
type: SpeciesReference
stoichiometry: 0.073
species: 868625

885621
type: SpeciesReference
stoichiometry: 0.002
species: 868109

885523
type: SpeciesReference
stoichiometry: 0.001
species: 866647

885573
type: SpeciesReference
stoichiometry: 0.124
species: 867952

867952
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecadienoyl-CoA (C18:2CoA, n-6)

885705
type: SpeciesReference
stoichiometry: 0.001
species: 868133

885426
type: SpeciesReference
stoichiometry: 0.013
species: 866161

866161
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Dodecanoyl-CoA (n-C12:0CoA)

885597
type: SpeciesReference
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species: 868012

868012
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecatrienoyl-CoA (C18:3CoA, n-6)

885486
type: SpeciesReference
stoichiometry: 0.003
species: 866586

885462
type: SpeciesReference
stoichiometry: 0.002
species: 866319

885548
type: SpeciesReference
stoichiometry: 0.06
species: 867300

867300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: hexadecenoyl-CoA (C16:1CoA, n-7)

885560
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stoichiometry: 0.001
species: 867408

885765
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value: 500.0

885753
type: LocalParameter
value: 0.0

885741
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value: 1000.0

885729
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value: 0.0

885693
type: SpeciesReference
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species: 865883

885669
type: SpeciesReference
stoichiometry: 0.034
species: 868686

885645
type: SpeciesReference
stoichiometry: 0.355
species: 868289

885414
type: SpeciesReference
stoichiometry: 0.001
species: 864917

864917
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 1-Acyl-sn-glycerol 3-phosphate, hepatocyte

885438
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species: 866283

866283
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosahexaenoyl-CoA (C22:6CoA, n-3)

885609
type: SpeciesReference
stoichiometry: 0.285
species: 868048

885681
type: SpeciesReference
stoichiometry: 0.001
species: 868710

885474
type: SpeciesReference
stoichiometry: 0.001
species: 866464

866464
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Eicosanoyl-CoA (n-C20:0CoA)

885585
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stoichiometry: 0.002
species: 868000

868000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecatrienoyl-CoA (C18:3CoA, n-3)

885510
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species: 866635

885633
type: SpeciesReference
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species: 868181

885535
type: SpeciesReference
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species: 866707

869885
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosatrienoyl-CoA (C20:3CoA, n-9)

927149
type: Reaction
product: 927197
notes: GENE_ASSOCIATION: NM_001984.1 GENE_LIST: NM_001984.1 SUBSYSTEM: Tyrosine metabolism
kinetic law: 927221
product: 927185
fast: false
reactant: 927161
reversible: false
reactant: 927173
product: 927209
name: S-Formylglutathione hydrolase

927197
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stoichiometry: 1.0
species: 867192

927270
type: LocalParameter
value: 500.0

927257
type: LocalParameter
value: 0.0

927245
type: LocalParameter
value: 1000.0

927233
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value: 0.0

927185
type: SpeciesReference
stoichiometry: 1.0
species: 866852

866852
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Formate

927161
type: SpeciesReference
stoichiometry: 1.0
species: 866840

866840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: S-Formylglutathione

927173
type: SpeciesReference
stoichiometry: 1.0
species: 867228

927209
type: SpeciesReference
stoichiometry: 1.0
species: 867216

879116
type: Reaction
kinetic law: 879152
product: 879140
reactant: 879128
fast: false
reversible: true
name: L-Proline exchange

879200
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value: 500.0

879188
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value: 0.0

879176
type: LocalParameter
value: 1000.0

879164
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value: 0.0

879140
type: SpeciesReference
stoichiometry: 1.0
species: 872715

879128
type: SpeciesReference
stoichiometry: 1.0
species: 864735

864735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Proline

869024
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

894941
type: Reaction
notes: GENE_ASSOCIATION: (NM_001096.2 or NM_198830.1) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Citric Acid Cycle
name: Citrate lyase (ATP-requiring)
product: 894989
product: 895014
product: 895002
fast: false
kinetic law: 895038
reactant: 894977
product: 895026
reversible: false
reactant: 894953
reactant: 894965

894989
type: SpeciesReference
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species: 865412

895014
type: SpeciesReference
stoichiometry: 1.0
species: 867879

867879
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Oxaloacetate

895002
type: SpeciesReference
stoichiometry: 1.0
species: 865460

895086
type: LocalParameter
value: 500.0

895074
type: LocalParameter
value: 0.0

895062
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value: 1000.0

895050
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value: 0.0

894977
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species: 865883

895026
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species: 868265

894953
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species: 865641

894965
type: SpeciesReference
stoichiometry: 1.0
species: 865823

865823
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Citrate

947777
type: Reaction
kinetic law: 947837
reactant: 947789
reactant: 947801
name: methenyltetrahydrofolate cyclohydrolase, mitochondrial
product: 947825
product: 947813
fast: false
reversible: true
notes: GENE_ASSOCIATION: (NM_006636.3 or NM_005956.2 or NM_015440.3) GENE_LIST: NM_005956.2 NM_006636.3 NM_015440.3 SUBSYSTEM: Folate Metabolism

947885
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value: 0.0

947873
type: LocalParameter
value: 0.0

947861
type: LocalParameter
value: 1000.0

947849
type: LocalParameter
value: -1000.0

947789
type: SpeciesReference
stoichiometry: 1.0
species: 870152

947801
type: SpeciesReference
stoichiometry: 1.0
species: 870371

870371
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 5,10-Methenyltetrahydrofolate

947825
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species: 870140

947813
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stoichiometry: 1.0
species: 869073

864626
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: octadecenoate (C18:1, n-9)

952681
type: Reaction
kinetic law: 952717
product: 952705
reactant: 952693
notes: GENE_ASSOCIATION: (NM_001048164.1 or NM_003046.2 or NM_018018.2 or NM_032803.3 or NM_001008539.1 or NM_003045.3) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_003045.3 NM_003046.2 NM_018018.2 NM_032803.3 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ornithine transport via diffusion, blood

952765
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value: 0.0

952753
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value: 0.0

952741
type: LocalParameter
value: 1000.0

952729
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value: -1000.0

952705
type: SpeciesReference
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species: 868072

952693
type: SpeciesReference
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species: 864687

864687
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Ornithine

956822
type: Reaction
kinetic law: 956858
product: 956846
reactant: 956834
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Heme transport to cytosol

956906
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value: 0.0

956894
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value: 0.0

956882
type: LocalParameter
value: 1000.0

956870
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value: -1000.0

956846
type: SpeciesReference
stoichiometry: 1.0
species: 868241

868241
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Protoheme

956834
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species: 870791

870791
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Protoheme

902766
type: Reaction
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
product: 902815
name: carnitine pentadecanoyltransferase (C15:0Crn), mitochondria
kinetic law: 902827
reactant: 902779
reactant: 902791
product: 902803

902815
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species: 870731

870731
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: pentadecanoyl-CoA (C15:0CoA)

902875
type: LocalParameter
value: 0.0

902863
type: LocalParameter
value: 0.0

902851
type: LocalParameter
value: 1000.0

902839
type: LocalParameter
value: -1000.0

902779
type: SpeciesReference
stoichiometry: 1.0
species: 869643

902791
type: SpeciesReference
stoichiometry: 1.0
species: 870743

870743
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: pentadecanoylcarnitine (C15:0Crn)

902803
type: SpeciesReference
stoichiometry: 1.0
species: 869655

946409
type: Reaction
kinetic law: 946446
product: 946433
reactant: 946421
notes: GENE_ASSOCIATION: NM_016368.3 GENE_LIST: NM_016368.3 SUBSYSTEM: Inositol Phosphate Metabolism
fast: false
reversible: false
name: myo-Inositol-1-phosphate synthase

946494
type: LocalParameter
value: 500.0

946482
type: LocalParameter
value: 0.0

946470
type: LocalParameter
value: 1000.0

946458
type: LocalParameter
value: 0.0

946433
type: SpeciesReference
stoichiometry: 1.0
species: 867722

867722
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 1D-myo-Inositol 1-phosphate

946421
type: SpeciesReference
stoichiometry: 1.0
species: 866962

866962
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Glucose 6-phosphate

941634
type: Reaction
reactant: 941660
reversible: false
notes: GENE_ASSOCIATION: (NM_000221.1 or NM_006488.1) GENE_LIST: NM_000221.1 NM_006488.1 SUBSYSTEM: Fructose and Mannose Metabolism
kinetic law: 941711
reactant: 941647
product: 941699
product: 941673
product: 941686
fast: false
name: ketohexokinase

941660
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stoichiometry: 1.0
species: 866912

866912
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Fructose

941760
type: LocalParameter
value: 500.0

941748
type: LocalParameter
value: 0.0

941735
type: LocalParameter
value: 1000.0

941723
type: LocalParameter
value: 0.0

941647
type: SpeciesReference
stoichiometry: 1.0
species: 865641

941699
type: SpeciesReference
stoichiometry: 1.0
species: 867216

941673
type: SpeciesReference
stoichiometry: 1.0
species: 865460

941686
type: SpeciesReference
stoichiometry: 1.0
species: 866732

911715
type: Reaction
product: 911765
reversible: false
name: deoxyuridine kinase (ATP:Deoxyuridine)
fast: false
kinetic law: 911789
product: 911753
product: 911777
reactant: 911741
notes: GENE_ASSOCIATION: NM_003258.1 GENE_LIST: NM_003258.1 SUBSYSTEM: Nucleotides
reactant: 911728

911765
type: SpeciesReference
stoichiometry: 1.0
species: 866404

911837
type: LocalParameter
value: 500.0

911825
type: LocalParameter
value: 0.0

911813
type: LocalParameter
value: 1000.0

911801
type: LocalParameter
value: 0.0

911753
type: SpeciesReference
stoichiometry: 1.0
species: 865460

911777
type: SpeciesReference
stoichiometry: 1.0
species: 867216

911741
type: SpeciesReference
stoichiometry: 1.0
species: 866416

911728
type: SpeciesReference
stoichiometry: 1.0
species: 865641

910016
type: Reaction
reactant: 910040
reactant: 910064
reversible: false
name: fatty acyl-CoA desaturase (C22:4CoA, n6 -> C22:5CoA, n6)
product: 910077
kinetic law: 910113
reactant: 910052
product: 910089
product: 910101
notes: SUBSYSTEM: Fatty Acid Synthesis
fast: false
reactant: 910028

910040
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stoichiometry: 1.0
species: 867830

910064
type: SpeciesReference
stoichiometry: 1.0
species: 868109

910077
type: SpeciesReference
stoichiometry: 1.0
species: 866319

910161
type: LocalParameter
value: 500.0

910149
type: LocalParameter
value: 0.0

910137
type: LocalParameter
value: 1000.0

910125
type: LocalParameter
value: 0.0

910052
type: SpeciesReference
stoichiometry: 1.0
species: 867854

910089
type: SpeciesReference
stoichiometry: 2.0
species: 867228

910101
type: SpeciesReference
stoichiometry: 1.0
species: 867818

910028
type: SpeciesReference
stoichiometry: 1.0
species: 867216

969206
type: Reaction
kinetic law: 969243
product: 969231
reactant: 969219
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: tetradecenoate (C14:1, n-7) transport

969292
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969280
type: LocalParameter
value: 0.0

969268
type: LocalParameter
value: 1000.0

969255
type: LocalParameter
value: -1000.0

969231
type: SpeciesReference
stoichiometry: 1.0
species: 864832

864832
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: tetradecenoate (C14:1, n-7)

969219
type: SpeciesReference
stoichiometry: 1.0
species: 868867

868867
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: tetradecenoate (C14:1, n-7)

932899
type: Reaction
reversible: true
reactant: 932935
kinetic law: 932995
name: glutamate dehydrogenase (NADP), mitochondrial
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reactant: 932911
reactant: 932923
product: 932971
product: 932947
notes: GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Glutamate metabolism
product: 932959
product: 932983

932935
type: SpeciesReference
stoichiometry: 1.0
species: 870474

933043
type: LocalParameter
value: 0.0

933031
type: LocalParameter
value: 0.0

933019
type: LocalParameter
value: 1000.0

933007
type: LocalParameter
value: -1000.0

932911
type: SpeciesReference
stoichiometry: 1.0
species: 870055

932923
type: SpeciesReference
stoichiometry: 1.0
species: 870152

932971
type: SpeciesReference
stoichiometry: 1.0
species: 870487

932947
type: SpeciesReference
stoichiometry: 1.0
species: 869448

932959
type: SpeciesReference
stoichiometry: 1.0
species: 870140

932983
type: SpeciesReference
stoichiometry: 1.0
species: 870500

870500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Ammonium

960043
type: Reaction
reactant: 960079
reactant: 960067
notes: GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Other
kinetic law: 960127
name: propionyl-CoA synthetase, mitochondrial
reversible: true
product: 960115
product: 960103
product: 960091
fast: false
reactant: 960055

960079
type: SpeciesReference
stoichiometry: 1.0
species: 870839

870839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Propionate

960067
type: SpeciesReference
stoichiometry: 1.0
species: 869643

960175
type: LocalParameter
value: 0.0

960163
type: LocalParameter
value: 0.0

960151
type: LocalParameter
value: 1000.0

960139
type: LocalParameter
value: -1000.0

960115
type: SpeciesReference
stoichiometry: 1.0
species: 870863

960103
type: SpeciesReference
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species: 870851

960091
type: SpeciesReference
stoichiometry: 1.0
species: 869472

869472
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: AMP

960055
type: SpeciesReference
stoichiometry: 1.0
species: 869509

908914
type: Reaction
product: 908986
kinetic law: 909010
notes: GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
name: linoleoyl-CoA desaturase (C18:1CoA,n-9 -> C18:2CoA,n-9)
reactant: 908926
reactant: 908962
product: 908974
reactant: 908950
reactant: 908938
reversible: false
product: 908998
fast: false

908986
type: SpeciesReference
stoichiometry: 1.0
species: 867492

909058
type: LocalParameter
value: 500.0

909046
type: LocalParameter
value: 0.0

909034
type: LocalParameter
value: 1000.0

909022
type: LocalParameter
value: 0.0

908926
type: SpeciesReference
stoichiometry: 1.0
species: 867216

908962
type: SpeciesReference
stoichiometry: 1.0
species: 868048

908974
type: SpeciesReference
stoichiometry: 2.0
species: 867228

908950
type: SpeciesReference
stoichiometry: 1.0
species: 867854

908938
type: SpeciesReference
stoichiometry: 1.0
species: 867830

908998
type: SpeciesReference
stoichiometry: 1.0
species: 867818

864066
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Alanine

877371
type: Reaction
kinetic law: 877411
product: 877398
reactant: 877385
fast: false
reversible: true
name: L-Lactate exchange

877461
type: LocalParameter
value: 500.0

877449
type: LocalParameter
value: 0.0

877437
type: LocalParameter
value: 1000.0

877424
type: LocalParameter
value: 0.0

877398
type: SpeciesReference
stoichiometry: 1.0
species: 872496

872496
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: lac_L_b

877385
type: SpeciesReference
stoichiometry: 1.0
species: 864515

864515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Lactate

875523
type: Reaction
kinetic law: 875559
product: 875547
reactant: 875535
fast: false
reversible: true
name: eicosatetraenoate (C20:4, n-6) exchange

875607
type: LocalParameter
value: 500.0

875595
type: LocalParameter
value: 0.0

875583
type: LocalParameter
value: 1000.0

875571
type: LocalParameter
value: 0.0

875547
type: SpeciesReference
stoichiometry: 1.0
species: 872266

875535
type: SpeciesReference
stoichiometry: 1.0
species: 864284

864284
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosatetraenoate (C20:4, n-6)

892442
type: Reaction
product: 892526
product: 892490
reactant: 892454
product: 892514
reversible: false
kinetic law: 892538
product: 892502
name: C-4 methyl sterol oxidase NADH
notes: GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 892466
reactant: 892478
fast: false

892526
type: SpeciesReference
stoichiometry: 1.0
species: 871566

871566
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: zymosterone

892490
type: SpeciesReference
stoichiometry: 1.0
species: 871300

871300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: CO2

892454
type: SpeciesReference
stoichiometry: 1.0
species: 871215

892514
type: SpeciesReference
stoichiometry: 1.0
species: 871445

871445
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Nicotinamide adenine dinucleotide - reduced

892586
type: LocalParameter
value: 500.0

892574
type: LocalParameter
value: 0.0

892562
type: LocalParameter
value: 1000.0

892550
type: LocalParameter
value: 0.0

892502
type: SpeciesReference
stoichiometry: 1.0
species: 871385

892466
type: SpeciesReference
stoichiometry: 1.0
species: 871433

892478
type: SpeciesReference
stoichiometry: 1.0
species: 871481

867107
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Glyceraldehyde

922504
type: Reaction
reactant: 922516
product: 922588
product: 922601
reversible: false
reactant: 922564
reactant: 922528
reactant: 922540
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
name: Beta oxidation of fatty acid
fast: false
kinetic law: 922626
product: 922576
reactant: 922552
product: 922613

922516
type: SpeciesReference
stoichiometry: 10.0
species: 869643

922588
type: SpeciesReference
stoichiometry: 5.0
species: 869957

922601
type: SpeciesReference
stoichiometry: 10.0
species: 870140

922564
type: SpeciesReference
stoichiometry: 10.0
species: 870448

922528
type: SpeciesReference
stoichiometry: 1.0
species: 869739

869739
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosapentaenoyl-CoA (C22:5CoA, n-3)

922540
type: SpeciesReference
stoichiometry: 5.0
species: 869945

922674
type: LocalParameter
value: 500.0

922662
type: LocalParameter
value: 0.0

922650
type: LocalParameter
value: 1000.0

922638
type: LocalParameter
value: 0.0

922576
type: SpeciesReference
stoichiometry: 11.0
species: 869412

922552
type: SpeciesReference
stoichiometry: 10.0
species: 870152

922613
type: SpeciesReference
stoichiometry: 10.0
species: 870461

872375
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: glyc_b

928753
type: Reaction
reactant: 928765
name: Formaldehyde activation (spontaneous)
reversible: false
fast: false
kinetic law: 928814
notes: SUBSYSTEM: Vitamins & Cofactor Biosynthesis
reactant: 928777
product: 928789
product: 928801

928765
type: SpeciesReference
stoichiometry: 1.0
species: 866792

928862
type: LocalParameter
value: 500.0

928850
type: LocalParameter
value: 0.0

928838
type: LocalParameter
value: 1000.0

928826
type: LocalParameter
value: 0.0

928777
type: SpeciesReference
stoichiometry: 1.0
species: 868758

928789
type: SpeciesReference
stoichiometry: 1.0
species: 867228

928801
type: SpeciesReference
stoichiometry: 1.0
species: 867734

878246
type: Reaction
kinetic law: 878282
product: 878270
reactant: 878258
fast: false
reversible: true
name: octadecenoate (C18:1, n-9) exchange

878330
type: LocalParameter
value: 500.0

878318
type: LocalParameter
value: 0.0

878306
type: LocalParameter
value: 1000.0

878294
type: LocalParameter
value: 0.0

878270
type: SpeciesReference
stoichiometry: 1.0
species: 872607

878258
type: SpeciesReference
stoichiometry: 1.0
species: 864626

965999
type: Reaction
product: 966047
reactant: 966035
name: delta24-sterol reductase
reactant: 966023
kinetic law: 966071
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: false
reactant: 966011
product: 966059

966047
type: SpeciesReference
stoichiometry: 1.0
species: 871288

871288
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Cholesterol

966035
type: SpeciesReference
stoichiometry: 1.0
species: 871469

966023
type: SpeciesReference
stoichiometry: 1.0
species: 871385

966120
type: LocalParameter
value: 500.0

966107
type: LocalParameter
value: 0.0

966095
type: LocalParameter
value: 1000.0

966083
type: LocalParameter
value: 0.0

966011
type: SpeciesReference
stoichiometry: 1.0
species: 871324

871324
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Desmosterol

966059
type: SpeciesReference
stoichiometry: 1.0
species: 871457

956361
type: Reaction
kinetic law: 956398
product: 956386
reactant: 956374
notes: GENE_ASSOCIATION: (NM_001029891.2 or NM_001724.3 or NM_002629.2 or NM_000290.2 or NM_199186.1) GENE_LIST: NM_000290.2 NM_001029891.2 NM_001724.3 NM_002629.2 NM_199186.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: phosphoglycerate mutase

956447
type: LocalParameter
value: 0.0

956435
type: LocalParameter
value: 0.0

956422
type: LocalParameter
value: 1000.0

956410
type: LocalParameter
value: -1000.0

956386
type: SpeciesReference
stoichiometry: 1.0
species: 865013

865013
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Glycerate 2-phosphate

956374
type: SpeciesReference
stoichiometry: 1.0
species: 865098

865098
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Phospho-D-glycerate

898433
type: Reaction
reactant: 898445
name: carnitine eicosatetraenoyltransferase (C20:4Crn, n6), mitochondrial
kinetic law: 898493
product: 898481
reactant: 898457
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 898469
reversible: true
fast: false

898445
type: SpeciesReference
stoichiometry: 1.0
species: 869655

898541
type: LocalParameter
value: 0.0

898529
type: LocalParameter
value: 0.0

898517
type: LocalParameter
value: 1000.0

898505
type: LocalParameter
value: -1000.0

898481
type: SpeciesReference
stoichiometry: 1.0
species: 869933

898457
type: SpeciesReference
stoichiometry: 1.0
species: 869921

869921
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)

898469
type: SpeciesReference
stoichiometry: 1.0
species: 869643

899034
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (NM_004377.2 or NM_001031847.1 or NM_152246.1 or NM_001876.2 or NM_152245.1 or NM_152247.1 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 899058
name: carnitine eicosatrienoyltransferase (C20:3Crn, n9)
reactant: 899046
kinetic law: 899094
product: 899082
product: 899070
fast: false

899058
type: SpeciesReference
stoichiometry: 1.0
species: 866647

899046
type: SpeciesReference
stoichiometry: 1.0
species: 865907

899143
type: LocalParameter
value: 0.0

899131
type: LocalParameter
value: 0.0

899119
type: LocalParameter
value: 1000.0

899106
type: LocalParameter
value: -1000.0

899082
type: SpeciesReference
stoichiometry: 1.0
species: 866671

899070
type: SpeciesReference
stoichiometry: 1.0
species: 865883

878535
type: Reaction
kinetic law: 878574
product: 878561
reactant: 878548
fast: false
reversible: true
name: octadecadienoate (C18:2, n-6) exchange

878623
type: LocalParameter
value: -0.001049328

878610
type: LocalParameter
value: 0.0

878598
type: LocalParameter
value: 0.0

878586
type: LocalParameter
value: -0.002098656

878561
type: SpeciesReference
stoichiometry: 1.0
species: 872643

872643
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ocddea6_b

878548
type: SpeciesReference
stoichiometry: 1.0
species: 864662

864564
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Methionine

864430
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Bicarbonate

877859
type: Reaction
kinetic law: 877895
product: 877883
reactant: 877871
fast: false
reversible: true
name: Sodium exchange

877943
type: LocalParameter
value: 0.0

877931
type: LocalParameter
value: 0.0

877919
type: LocalParameter
value: 1000.0

877907
type: LocalParameter
value: -1000.0

877883
type: SpeciesReference
stoichiometry: 1.0
species: 872557

872557
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: na1_b

877871
type: SpeciesReference
stoichiometry: 1.0
species: 864576

872038
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: acac_b

864163
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: docosahexaenoate (C22:6, n-3)

878635
type: Reaction
kinetic law: 878671
product: 878659
reactant: 878647
fast: false
reversible: true
name: ocosatetraenoate (C22:4, n-6) exchange

878719
type: LocalParameter
value: 500.0

878707
type: LocalParameter
value: 0.0

878695
type: LocalParameter
value: 1000.0

878683
type: LocalParameter
value: 0.0

878659
type: SpeciesReference
stoichiometry: 1.0
species: 872655

872655
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ocsttea6_b

878647
type: SpeciesReference
stoichiometry: 1.0
species: 864674

864674
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: ocosatetraenoate (C22:4, n-6)

868085
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Orotate

872483
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: lac_D_b

867035
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Glucose

897213
type: Reaction
kinetic law: 897273
reactant: 897237
reversible: true
product: 897249
name: carnitine docosapentaenoyltransferase (C22:5Crn, n6), mitochondrial
fast: false
product: 897261
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 897225

897322
type: LocalParameter
value: 0.0

897310
type: LocalParameter
value: 0.0

897298
type: LocalParameter
value: 1000.0

897285
type: LocalParameter
value: -1000.0

897237
type: SpeciesReference
stoichiometry: 1.0
species: 869751

869751
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosapentaenoyl-CoA (C22:5CoA, n-6)

897249
type: SpeciesReference
stoichiometry: 1.0
species: 869643

897261
type: SpeciesReference
stoichiometry: 1.0
species: 869775

869775
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosapentaenoyl carnitine (C22:5Crn, n-6)

897225
type: SpeciesReference
stoichiometry: 1.0
species: 869655

865110
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Phosphohydroxypyruvate

968520
type: Reaction
reversible: false
kinetic law: 968593
product: 968568
notes: GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Triglycerol Degradation
product: 968556
reactant: 968532
name: triacylglycerol hydrolase, human hepatocyte
product: 968581
fast: false
reactant: 968544

968641
type: LocalParameter
value: 500.0

968629
type: LocalParameter
value: 0.0

968617
type: LocalParameter
value: 1000.0

968605
type: LocalParameter
value: 0.0

968568
type: SpeciesReference
stoichiometry: 0.001
species: 866768

968556
type: SpeciesReference
stoichiometry: 0.001
species: 864893

968532
type: SpeciesReference
stoichiometry: 1.0
species: 867228

968581
type: SpeciesReference
stoichiometry: 1.0
species: 867216

968544
type: SpeciesReference
stoichiometry: 0.001
species: 868818

915187
type: Reaction
product: 915236
product: 915260
reactant: 915199
reactant: 915223
fast: false
name: fatty-acid--CoA ligase (eicosenoate, C20:1 n-9)
reversible: true
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
product: 915248
reactant: 915211
kinetic law: 915272

915236
type: SpeciesReference
stoichiometry: 1.0
species: 865568

915260
type: SpeciesReference
stoichiometry: 1.0
species: 868361

915199
type: SpeciesReference
stoichiometry: 1.0
species: 865641

915223
type: SpeciesReference
stoichiometry: 1.0
species: 866500

866500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosenoate (C20:1, n-9)

915248
type: SpeciesReference
stoichiometry: 1.0
species: 866586

915211
type: SpeciesReference
stoichiometry: 1.0
species: 865883

915320
type: LocalParameter
value: 0.0

915308
type: LocalParameter
value: 0.0

915296
type: LocalParameter
value: 1000.0

915284
type: LocalParameter
value: -1000.0

895243
type: Reaction
kinetic law: 895280
product: 895267
reactant: 895255
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: cardiolipin reversible transport, mitochondria, hepatocyte

895329
type: LocalParameter
value: 0.0

895317
type: LocalParameter
value: 0.0

895305
type: LocalParameter
value: 1000.0

895293
type: LocalParameter
value: -1000.0

895267
type: SpeciesReference
stoichiometry: 1.0
species: 865847

895255
type: SpeciesReference
stoichiometry: 1.0
species: 869607

869607
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: cardiolipin, hepatocyte

918393
type: Reaction
product: 918502
reactant: 918453
reactant: 918441
product: 918477
fast: false
product: 918490
kinetic law: 918526
name: Beta oxidation of fatty acid
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 918417
reactant: 918405
product: 918514
product: 918465
reactant: 918429
reversible: false

918502
type: SpeciesReference
stoichiometry: 1.0
species: 870461

918453
type: SpeciesReference
stoichiometry: 1.0
species: 870448

918441
type: SpeciesReference
stoichiometry: 1.0
species: 870152

918477
type: SpeciesReference
stoichiometry: 1.0
species: 869957

918490
type: SpeciesReference
stoichiometry: 1.0
species: 870140

918574
type: LocalParameter
value: 500.0

918562
type: LocalParameter
value: 0.0

918550
type: LocalParameter
value: 1000.0

918538
type: LocalParameter
value: 0.0

918417
type: SpeciesReference
stoichiometry: 1.0
species: 869679

869679
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Decanoyl-CoA (C10:0CoA)

918405
type: SpeciesReference
stoichiometry: 1.0
species: 869643

918514
type: SpeciesReference
stoichiometry: 1.0
species: 870563

918465
type: SpeciesReference
stoichiometry: 1.0
species: 869412

918429
type: SpeciesReference
stoichiometry: 1.0
species: 869945

941904
type: Reaction
reactant: 941953
notes: GENE_ASSOCIATION: NM_003679.2 GENE_LIST: NM_003679.2 SUBSYSTEM: Tryptophan metabolism
fast: false
product: 941977
reactant: 941916
product: 941965
reactant: 941941
kinetic law: 942001
reactant: 941928
name: kynurenine 3-monooxygenase
product: 941989
reversible: true

941953
type: SpeciesReference
stoichiometry: 1.0
species: 867854

941977
type: SpeciesReference
stoichiometry: 1.0
species: 867348

867348
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Hydroxy-L-kynurenine

941916
type: SpeciesReference
stoichiometry: 1.0
species: 867216

941965
type: SpeciesReference
stoichiometry: 1.0
species: 867228

941941
type: SpeciesReference
stoichiometry: 1.0
species: 867830

942051
type: LocalParameter
value: 0.0

942038
type: LocalParameter
value: 0.0

942026
type: LocalParameter
value: 1000.0

942013
type: LocalParameter
value: -1000.0

941928
type: SpeciesReference
stoichiometry: 1.0
species: 867553

867553
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Kynurenine

941989
type: SpeciesReference
stoichiometry: 1.0
species: 867818

951792
type: Reaction
kinetic law: 951828
product: 951816
reactant: 951804
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: octadecenoate (C18:1, n-9)transport

951876
type: LocalParameter
value: 0.0

951864
type: LocalParameter
value: 0.0

951852
type: LocalParameter
value: 1000.0

951840
type: LocalParameter
value: -1000.0

951816
type: SpeciesReference
stoichiometry: 1.0
species: 864626

951804
type: SpeciesReference
stoichiometry: 1.0
species: 867903

908758
type: Reaction
reactant: 908770
product: 908830
fast: false
notes: GENE_ASSOCIATION: (NM_001037582.1 or NM_024906.1 or NM_005063.4) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Synthesis
product: 908842
kinetic law: 908854
reversible: false
name: stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-9), adipocyte
reactant: 908794
product: 908818
reactant: 908782
reactant: 908806

908770
type: SpeciesReference
stoichiometry: 1.0
species: 867216

908830
type: SpeciesReference
stoichiometry: 1.0
species: 867818

908842
type: SpeciesReference
stoichiometry: 1.0
species: 868048

908902
type: LocalParameter
value: 500.0

908890
type: LocalParameter
value: 0.0

908878
type: LocalParameter
value: 1000.0

908866
type: LocalParameter
value: 0.0

908794
type: SpeciesReference
stoichiometry: 1.0
species: 867854

908818
type: SpeciesReference
stoichiometry: 2.0
species: 867228

908782
type: SpeciesReference
stoichiometry: 1.0
species: 867830

908806
type: SpeciesReference
stoichiometry: 1.0
species: 868625

935592
type: Reaction
reactant: 935616
reversible: false
notes: GENE_ASSOCIATION: (NM_000161.2 or NM_001024024.1) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
product: 935640
kinetic law: 935665
product: 935628
reactant: 935604
name: GTP cyclohydrolase I
fast: false
product: 935653

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species: 867228

935640
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species: 866852

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value: 500.0

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value: 0.0

935689
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value: 1000.0

935677
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935628
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species: 865484

935604
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species: 867204

935653
type: SpeciesReference
stoichiometry: 1.0
species: 867216

931151
type: Reaction
reactant: 931163
reactant: 931187
product: 931211
notes: GENE_ASSOCIATION: (NM_013976.2 or NM_000159.2) GENE_LIST: NM_000159.2 NM_013976.2 SUBSYSTEM: Tryptophan metabolism
product: 931199
reversible: true
name: glutaryl-CoA dehydrogenase, mitochondrial
product: 931223
kinetic law: 931235
fast: false
reactant: 931175

931163
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stoichiometry: 1.0
species: 869945

931187
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species: 870140

931211
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species: 869631

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species: 869522

869522
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: trans-But-2-enoyl-CoA

931223
type: SpeciesReference
stoichiometry: 1.0
species: 869957

931284
type: LocalParameter
value: 0.0

931272
type: LocalParameter
value: 0.0

931260
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value: 1000.0

931247
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value: -1000.0

931175
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species: 870092

870092
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Glutaryl-CoA

960957
type: Reaction
notes: GENE_ASSOCIATION: (NM_001077484.1 or NM_030674.2 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
fast: false
product: 961005
reactant: 960969
reactant: 960981
kinetic law: 961017
name: Na+/Proline-L symporter, blood
product: 960993
reversible: true

961005
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species: 868421

960969
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species: 864576

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species: 864735

961066
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961054
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961042
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961029
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960993
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species: 867782

910846
type: Reaction
product: 910882
reactant: 910870
reversible: true
reactant: 910858
name: dihydroorotase
product: 910894
fast: false
kinetic law: 910906
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Biosynthesis

910882
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species: 865677

865677
type: Species
constant: false
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N-Carbamoyl-L-aspartate

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species: 867228

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species: 866247

866247
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constant: false
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (S)-Dihydroorotate

910894
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stoichiometry: 1.0
species: 867216

910955
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value: 0.0

910943
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value: 0.0

910930
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910918
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871833
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constant: false
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: H2O

865194
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 4-Methyl-2-oxopentanoate

903007
type: Reaction
reactant: 903031
reactant: 903019
notes: SUBSYSTEM: Carnitine Shuttle
product: 903056
product: 903044
name: carnitine propionyltransferase
reversible: true
kinetic law: 903068
fast: false

903031
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species: 868349

868349
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Propanoyl-CoA (C3:0CoA)

903019
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species: 865907

903056
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species: 868169

903044
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species: 865883

903117
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903105
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value: 0.0

903092
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value: 1000.0

903080
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value: -1000.0

962652
type: Reaction
reactant: 962676
fast: false
product: 962688
name: ribonucleoside-diphosphate reductase (GDP)
product: 962712
product: 962700
reactant: 962664
kinetic law: 962724
reversible: false
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotides

962676
type: SpeciesReference
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species: 868806

962688
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species: 866185

866185
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dGDP

962712
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species: 868794

962700
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species: 867228

962664
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species: 867023

867023
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: GDP

962772
type: LocalParameter
value: 500.0

962760
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value: 0.0

962748
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value: 1000.0

962736
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value: 0.0

948416
type: Reaction
fast: false
product: 948452
notes: GENE_ASSOCIATION: (NM_003048.3 or NM_004174.1 or NM_001011552.1 or NM_173653.1 or NM_003047.2 or NM_004594.1) GENE_LIST: NM_001011552.1 NM_003047.2 NM_003048.3 NM_004174.1 NM_004594.1 NM_173653.1 SUBSYSTEM: Transport, Extracellular
reactant: 948440
product: 948464
reversible: true
name: sodium transport in/out via proton antiport (one H+), blood
kinetic law: 948476
reactant: 948428

948452
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species: 864576

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species: 867782

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species: 867216

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value: 0.0

948512
type: LocalParameter
value: 0.0

948500
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value: 1000.0

948488
type: LocalParameter
value: -1000.0

948428
type: SpeciesReference
stoichiometry: 1.0
species: 864405

869969
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Fe2+

903129
type: Reaction
product: 903165
reactant: 903153
name: carnitine propionyltransferase
fast: false
product: 903177
reactant: 903141
notes: SUBSYSTEM: Carnitine Shuttle
kinetic law: 903189
reversible: true

903165
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stoichiometry: 1.0
species: 865907

903153
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stoichiometry: 1.0
species: 869655

903177
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species: 870719

870719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: propionyl-carnitine

903141
type: SpeciesReference
stoichiometry: 1.0
species: 868169

903237
type: LocalParameter
value: 0.0

903225
type: LocalParameter
value: 0.0

903213
type: LocalParameter
value: 1000.0

903201
type: LocalParameter
value: -1000.0

955636
type: Reaction
notes: GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Amino Acid Metabolism
fast: false
product: 955696
reactant: 955660
product: 955672
reversible: true
kinetic law: 955708
name: phosphoglycerate dehydrogenase
reactant: 955648
product: 955684

955696
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stoichiometry: 1.0
species: 867806

955660
type: SpeciesReference
stoichiometry: 1.0
species: 867794

955672
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stoichiometry: 1.0
species: 865110

955756
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value: 0.0

955744
type: LocalParameter
value: 0.0

955732
type: LocalParameter
value: 1000.0

955720
type: LocalParameter
value: -1000.0

955648
type: SpeciesReference
stoichiometry: 1.0
species: 865098

955684
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stoichiometry: 1.0
species: 867216

869158
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 2-Methylprop-2-enoyl-CoA

872158
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: dcspea3_b

966132
type: Reaction
reactant: 966168
reactant: 966156
name: delta24-sterol reductase
kinetic law: 966205
reversible: false
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Biosynthesis
product: 966180
product: 966193
fast: false
reactant: 966144

966168
type: SpeciesReference
stoichiometry: 1.0
species: 871469

966156
type: SpeciesReference
stoichiometry: 1.0
species: 871385

966253
type: LocalParameter
value: 500.0

966241
type: LocalParameter
value: 0.0

966229
type: LocalParameter
value: 1000.0

966217
type: LocalParameter
value: 0.0

966180
type: SpeciesReference
stoichiometry: 1.0
species: 871421

966193
type: SpeciesReference
stoichiometry: 1.0
species: 871457

966144
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stoichiometry: 1.0
species: 871275

872339
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: gln_L_b

970005
type: Reaction
name: UMP kinase
reactant: 970029
notes: GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
kinetic law: 970065
product: 970041
reactant: 970017
product: 970053
reversible: true

970029
type: SpeciesReference
stoichiometry: 1.0
species: 868927

970113
type: LocalParameter
value: 0.0

970101
type: LocalParameter
value: 0.0

970089
type: LocalParameter
value: 1000.0

970077
type: LocalParameter
value: -1000.0

970041
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stoichiometry: 1.0
species: 865460

970017
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species: 865641

970053
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stoichiometry: 1.0
species: 868891

885777
type: Reaction
reversible: true
fast: false
kinetic law: 885837
notes: GENE_ASSOCIATION: (NM_000687.1 or NM_006621.3 or NM_015328.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Methionine Metabolism
name: adenosylhomocysteinase
reactant: 885801
reactant: 885789
product: 885825
product: 885813

885885
type: LocalParameter
value: 0.0

885873
type: LocalParameter
value: 0.0

885861
type: LocalParameter
value: 1000.0

885849
type: LocalParameter
value: -1000.0

885801
type: SpeciesReference
stoichiometry: 1.0
species: 867228

885789
type: SpeciesReference
stoichiometry: 1.0
species: 865472

885825
type: SpeciesReference
stoichiometry: 1.0
species: 867264

867264
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Homocysteine

885813
type: SpeciesReference
stoichiometry: 1.0
species: 865448

865448
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Adenosine

917331
type: Reaction
reactant: 917392
name: fatty-acyl-CoA elongation (C20:2CoA, n9)
product: 917428
reactant: 917355
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 917368
product: 917416
product: 917404
fast: false
product: 917452
product: 917440
kinetic law: 917464
reversible: false
reactant: 917380
reactant: 917343

917392
type: SpeciesReference
stoichiometry: 1.0
species: 867854

917428
type: SpeciesReference
stoichiometry: 1.0
species: 866573

866573
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosadienoyl-CoA (C20:2CoA, n-9)

917355
type: SpeciesReference
stoichiometry: 1.0
species: 867492

917368
type: SpeciesReference
stoichiometry: 1.0
species: 867638

917416
type: SpeciesReference
stoichiometry: 1.0
species: 865883

917404
type: SpeciesReference
stoichiometry: 1.0
species: 865871

917452
type: SpeciesReference
stoichiometry: 4.0
species: 867818

917440
type: SpeciesReference
stoichiometry: 3.0
species: 867228

917512
type: LocalParameter
value: 500.0

917500
type: LocalParameter
value: 0.0

917488
type: LocalParameter
value: 1000.0

917476
type: LocalParameter
value: 0.0

917380
type: SpeciesReference
stoichiometry: 4.0
species: 867830

917343
type: SpeciesReference
stoichiometry: 5.0
species: 867216

864503
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: D-Lactate

951275
type: Reaction
kinetic law: 951311
product: 951299
reactant: 951287
notes: SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: O2 endoplamic reticulum transport

951359
type: LocalParameter
value: 0.0

951347
type: LocalParameter
value: 0.0

951335
type: LocalParameter
value: 1000.0

951323
type: LocalParameter
value: -1000.0

951299
type: SpeciesReference
stoichiometry: 1.0
species: 871481

951287
type: SpeciesReference
stoichiometry: 1.0
species: 867854

880779
type: Reaction
notes: GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
reactant: 880791
reversible: false
reactant: 880815
kinetic law: 880863
reactant: 880803
fast: false
product: 880851
product: 880839
product: 880827
name: cysteinesulfinate-aspartate mitochondrial shuttle

880791
type: SpeciesReference
stoichiometry: 1.0
species: 867059

880815
type: SpeciesReference
stoichiometry: 1.0
species: 869303

869303
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3-Sulfino-L-alanine

880911
type: LocalParameter
value: 500.0

880899
type: LocalParameter
value: 0.0

880887
type: LocalParameter
value: 1000.0

880875
type: LocalParameter
value: 0.0

880803
type: SpeciesReference
stoichiometry: 1.0
species: 867216

880851
type: SpeciesReference
stoichiometry: 1.0
species: 870140

880839
type: SpeciesReference
stoichiometry: 1.0
species: 870055

880827
type: SpeciesReference
stoichiometry: 1.0
species: 865122

916933
type: Reaction
reactant: 916957
product: 917247
reactant: 917163
reactant: 917078
reactant: 916993
reactant: 917187
reactant: 917102
reactant: 917017
reactant: 917126
name: Average fatty acyl-coa, hepatocyte
reactant: 916945
fast: false
kinetic law: 917271
reactant: 917223
reactant: 917151
reactant: 917029
reactant: 917041
reactant: 917066
reactant: 916969
reactant: 916981
reactant: 917175
reactant: 917005
product: 917235
reversible: true
reactant: 917199
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_015256.2 or NM_022977.1 or NM_016234.3 or NM_203380.1 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_001009185.1 or NM_203379.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reactant: 917114
product: 917259
reactant: 917138
reactant: 917090
reactant: 917211
reactant: 917054

916957
type: SpeciesReference
stoichiometry: 1.0
species: 865883

917247
type: SpeciesReference
stoichiometry: 0.001
species: 866780

866780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: average fatty-acyl CoA, human hepatocyte

917163
type: SpeciesReference
stoichiometry: 0.001
species: 867928

917078
type: SpeciesReference
stoichiometry: 0.027
species: 866561

866561
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatetraenoate (C20:4, n-6)

916993
type: SpeciesReference
stoichiometry: 0.002
species: 866113

866113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoate (C22:5, n-6)

917187
type: SpeciesReference
stoichiometry: 0.002
species: 867976

917102
type: SpeciesReference
stoichiometry: 0.06
species: 867288

917017
type: SpeciesReference
stoichiometry: 0.001
species: 866452

917126
type: SpeciesReference
stoichiometry: 0.073
species: 867891

916945
type: SpeciesReference
stoichiometry: 1.0
species: 865641

917319
type: LocalParameter
value: 0.0

917307
type: LocalParameter
value: 0.0

917295
type: LocalParameter
value: 1000.0

917283
type: LocalParameter
value: -1000.0

917223
type: SpeciesReference
stoichiometry: 0.001
species: 868867

917151
type: SpeciesReference
stoichiometry: 0.002
species: 867915

917029
type: SpeciesReference
stoichiometry: 0.003
species: 866500

917041
type: SpeciesReference
stoichiometry: 0.001
species: 866512

917066
type: SpeciesReference
stoichiometry: 0.001
species: 866536

916969
type: SpeciesReference
stoichiometry: 0.005
species: 866088

866088
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosahexaenoate (C22:6, n-3)

916981
type: SpeciesReference
stoichiometry: 0.002
species: 866101

917175
type: SpeciesReference
stoichiometry: 0.124
species: 867940

917005
type: SpeciesReference
stoichiometry: 0.013
species: 866149

917235
type: SpeciesReference
stoichiometry: 1.0
species: 865568

917199
type: SpeciesReference
stoichiometry: 0.003
species: 868469

917114
type: SpeciesReference
stoichiometry: 0.001
species: 867396

917259
type: SpeciesReference
stoichiometry: 1.0
species: 868361

917138
type: SpeciesReference
stoichiometry: 0.285
species: 867903

917090
type: SpeciesReference
stoichiometry: 0.355
species: 867276

917211
type: SpeciesReference
stoichiometry: 0.034
species: 868854

917054
type: SpeciesReference
stoichiometry: 0.004
species: 866524

866524
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatrienoate (C20:3, n-6)

958629
type: Reaction
reactant: 958653
reversible: false
reactant: 958641
fast: false
product: 958689
notes: SUBSYSTEM: Other
product: 958665
name: inorganic triphosphatase
kinetic law: 958701
product: 958677

958653
type: SpeciesReference
stoichiometry: 1.0
species: 868397

868397
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Inorganic triphosphate

958641
type: SpeciesReference
stoichiometry: 1.0
species: 867228

958689
type: SpeciesReference
stoichiometry: 1.0
species: 868361

958665
type: SpeciesReference
stoichiometry: 1.0
species: 867216

958750
type: LocalParameter
value: 500.0

958738
type: LocalParameter
value: 0.0

958725
type: LocalParameter
value: 1000.0

958713
type: LocalParameter
value: 0.0

958677
type: SpeciesReference
stoichiometry: 1.0
species: 868265

950803
type: Reaction
kinetic law: 950865
name: 5'-nucleotidase (dTMP)
reactant: 950815
fast: false
reversible: false
notes: GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Pyrimidine Catabolism
product: 950840
product: 950852
reactant: 950827

950913
type: LocalParameter
value: 500.0

950901
type: LocalParameter
value: 0.0

950889
type: LocalParameter
value: 1000.0

950877
type: LocalParameter
value: 0.0

950815
type: SpeciesReference
stoichiometry: 1.0
species: 866368

950840
type: SpeciesReference
stoichiometry: 1.0
species: 868265

950852
type: SpeciesReference
stoichiometry: 1.0
species: 868782

868782
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Thymidine

950827
type: SpeciesReference
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species: 867228

884461
type: Reaction
kinetic law: 884509
product: 884497
reactant: 884485
reactant: 884473
notes: GENE_ASSOCIATION: (NM_013410.2 or NM_001005353.1 or NM_203464.1 or NM_001625.2 or NM_013411.3) GENE_LIST: NM_001005353.1 NM_001625.2 NM_013410.2 NM_013411.3 NM_203464.1 SUBSYSTEM: Nucleotides
fast: false
reversible: true
name: adenylate kinase, mitochondrial

884558
type: LocalParameter
value: 0.0

884546
type: LocalParameter
value: 0.0

884533
type: LocalParameter
value: 1000.0

884521
type: LocalParameter
value: -1000.0

884497
type: SpeciesReference
stoichiometry: 2.0
species: 869436

884485
type: SpeciesReference
stoichiometry: 1.0
species: 869509

884473
type: SpeciesReference
stoichiometry: 1.0
species: 869472

871761
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Dimethylallyl diphosphate

891221
type: Reaction
product: 891282
product: 891270
reversible: false
kinetic law: 891294
reactant: 891233
product: 891258
fast: false
name: ATPase, cytosolic
notes: SUBSYSTEM: Other
reactant: 891245

891282
type: SpeciesReference
stoichiometry: 1.0
species: 868265

891270
type: SpeciesReference
stoichiometry: 1.0
species: 865460

891342
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value: 500.0

891330
type: LocalParameter
value: 0.0

891318
type: LocalParameter
value: 1000.0

891306
type: LocalParameter
value: 0.0

891233
type: SpeciesReference
stoichiometry: 1.0
species: 865641

891258
type: SpeciesReference
stoichiometry: 1.0
species: 864405

891245
type: SpeciesReference
stoichiometry: 1.0
species: 867228

951046
type: Reaction
reactant: 951058
reactant: 951070
product: 951082
fast: false
product: 951094
notes: SUBSYSTEM: Nucleotide Metabolism
name: Nucleoside triphosphate pyrophosphorylase (atp)
product: 951107
reversible: false
kinetic law: 951119

951058
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stoichiometry: 1.0
species: 869509

951070
type: SpeciesReference
stoichiometry: 1.0
species: 870152

951082
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species: 869472

951094
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species: 870140

951107
type: SpeciesReference
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species: 870863

951167
type: LocalParameter
value: 500.0

951155
type: LocalParameter
value: 0.0

951143
type: LocalParameter
value: 1000.0

951131
type: LocalParameter
value: 0.0

964411
type: Reaction
kinetic law: 964471
product: 964447
product: 964459
name: sulfate sodium symport, blood
fast: false
notes: SUBSYSTEM: Transport, Extracellular
reversible: true
reactant: 964423
reactant: 964435

964519
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value: 0.0

964507
type: LocalParameter
value: 0.0

964495
type: LocalParameter
value: 1000.0

964483
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value: -1000.0

964447
type: SpeciesReference
stoichiometry: 1.0
species: 867782

964459
type: SpeciesReference
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species: 868565

964423
type: SpeciesReference
stoichiometry: 1.0
species: 864576

964435
type: SpeciesReference
stoichiometry: 1.0
species: 864784

864784
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Sulfite

878051
type: Reaction
kinetic law: 878088
product: 878075
reactant: 878063
fast: false
reversible: true
name: O2 exchange

878136
type: LocalParameter
value: 0.0

878124
type: LocalParameter
value: 0.0

878112
type: LocalParameter
value: 1000.0

878100
type: LocalParameter
value: -1000.0

878075
type: SpeciesReference
stoichiometry: 1.0
species: 872582

872582
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: o2_b

878063
type: SpeciesReference
stoichiometry: 1.0
species: 864601

870767
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Phosphatidylglycerol, human hepatocyte

915476
type: Reaction
name: fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
product: 915524
reactant: 915488
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reactant: 915500
reversible: true
kinetic law: 915560
reactant: 915512
product: 915548
product: 915536
fast: false

915524
type: SpeciesReference
stoichiometry: 1.0
species: 865568

915488
type: SpeciesReference
stoichiometry: 1.0
species: 865641

915500
type: SpeciesReference
stoichiometry: 1.0
species: 865883

915608
type: LocalParameter
value: 0.0

915596
type: LocalParameter
value: 0.0

915584
type: LocalParameter
value: 1000.0

915572
type: LocalParameter
value: -1000.0

915512
type: SpeciesReference
stoichiometry: 1.0
species: 866524

915548
type: SpeciesReference
stoichiometry: 1.0
species: 868361

915536
type: SpeciesReference
stoichiometry: 1.0
species: 866635

869763
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosapentaenoyl carnitine (C22:5Crn, n-3)

866900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Farnesyl diphosphate

934409
type: Reaction
name: hydroxyacylglutathione hydrolase
notes: GENE_ASSOCIATION: (NM_032304.2 or NM_207112.1 or NM_005326.4 or NM_001040427.1) GENE_LIST: NM_001040427.1 NM_005326.4 NM_032304.2 NM_207112.1 SUBSYSTEM: Pyruvate Metabolism
product: 934469
reversible: false
reactant: 934421
product: 934445
reactant: 934433
kinetic law: 934481
product: 934457
fast: false

934469
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stoichiometry: 1.0
species: 867565

867565
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Lactate

934421
type: SpeciesReference
stoichiometry: 1.0
species: 867228

934445
type: SpeciesReference
stoichiometry: 1.0
species: 867192

934433
type: SpeciesReference
stoichiometry: 1.0
species: 867601

867601
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (R)-S-Lactoylglutathione

934529
type: LocalParameter
value: 500.0

934517
type: LocalParameter
value: 0.0

934505
type: LocalParameter
value: 1000.0

934493
type: LocalParameter
value: 0.0

934457
type: SpeciesReference
stoichiometry: 1.0
species: 867216

867758
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (S)-Methylmalonate semialdehyde

967918
type: Reaction
name: transketolase
kinetic law: 967978
reactant: 967942
notes: GENE_ASSOCIATION: (NM_032136.3 or NM_012253.2 or NM_001064.1) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 967930
product: 967966
fast: false
product: 967954
reversible: true

968026
type: LocalParameter
value: 0.0

968014
type: LocalParameter
value: 0.0

968002
type: LocalParameter
value: 1000.0

967990
type: LocalParameter
value: -1000.0

967942
type: SpeciesReference
stoichiometry: 1.0
species: 869061

967930
type: SpeciesReference
stoichiometry: 1.0
species: 866440

866440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Erythrose 4-phosphate

967966
type: SpeciesReference
stoichiometry: 1.0
species: 866950

967954
type: SpeciesReference
stoichiometry: 1.0
species: 866756

865436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: O-Acetylcarnitine

865689
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Carbamoyl phosphate

871990
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Taurine

883570
type: Reaction
kinetic law: 883606
product: 883594
reactant: 883582
notes: GENE_ASSOCIATION: NM_001098.2 GENE_LIST: NM_001098.2 SUBSYSTEM: Citrate Cycle (TCA)
fast: false
reversible: true
name: Aconitate hydratase

883654
type: LocalParameter
value: 0.0

883642
type: LocalParameter
value: 0.0

883630
type: LocalParameter
value: 1000.0

883618
type: LocalParameter
value: -1000.0

883594
type: SpeciesReference
stoichiometry: 1.0
species: 870299

883582
type: SpeciesReference
stoichiometry: 1.0
species: 869583

879796
type: Reaction
kinetic law: 879833
product: 879821
reactant: 879808
fast: false
reversible: true
name: tetradecanoate (C14:0) exchange

879881
type: LocalParameter
value: 500.0

879869
type: LocalParameter
value: 0.0

879857
type: LocalParameter
value: 1000.0

879845
type: LocalParameter
value: 0.0

879821
type: SpeciesReference
stoichiometry: 1.0
species: 872803

872803
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ttdca_b

879808
type: SpeciesReference
stoichiometry: 1.0
species: 864820

864820
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: tetradecanoate (C14:0)

944892
type: Reaction
fast: false
reactant: 944916
product: 944952
reversible: true
product: 944940
kinetic law: 944965
reactant: 944904
name: malate dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citric Acid Cycle
product: 944928

944916
type: SpeciesReference
stoichiometry: 1.0
species: 870448

944952
type: SpeciesReference
stoichiometry: 1.0
species: 870551

944940
type: SpeciesReference
stoichiometry: 1.0
species: 870461

945013
type: LocalParameter
value: 0.0

945001
type: LocalParameter
value: 0.0

944989
type: LocalParameter
value: 1000.0

944977
type: LocalParameter
value: -1000.0

944904
type: SpeciesReference
stoichiometry: 1.0
species: 870359

944928
type: SpeciesReference
stoichiometry: 1.0
species: 870140

967348
type: Reaction
kinetic law: 967384
product: 967372
reactant: 967360
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial

967432
type: LocalParameter
value: 0.0

967420
type: LocalParameter
value: 0.0

967408
type: LocalParameter
value: 1000.0

967396
type: LocalParameter
value: -1000.0

967372
type: SpeciesReference
stoichiometry: 1.0
species: 871094

967360
type: SpeciesReference
stoichiometry: 1.0
species: 868758

917719
type: Reaction
product: 917827
product: 917815
product: 917803
reactant: 917767
name: fatty-acyl-CoA elongation (C20:4CoA, n3)
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 917779
fast: false
reactant: 917743
reactant: 917755
kinetic law: 917851
product: 917791
reversible: false
reactant: 917731
product: 917839

917827
type: SpeciesReference
stoichiometry: 3.0
species: 867228

917815
type: SpeciesReference
stoichiometry: 1.0
species: 866695

866695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatetraenoyl-CoA (C20:4CoA, n-3)

917803
type: SpeciesReference
stoichiometry: 1.0
species: 865883

917767
type: SpeciesReference
stoichiometry: 1.0
species: 867854

917779
type: SpeciesReference
stoichiometry: 1.0
species: 868649

868649
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: stearidonyl coenzyme A (C18:4CoA, n-3)

917743
type: SpeciesReference
stoichiometry: 1.0
species: 867638

917755
type: SpeciesReference
stoichiometry: 4.0
species: 867830

917899
type: LocalParameter
value: 500.0

917887
type: LocalParameter
value: 0.0

917875
type: LocalParameter
value: 1000.0

917863
type: LocalParameter
value: 0.0

917791
type: SpeciesReference
stoichiometry: 1.0
species: 865871

917731
type: SpeciesReference
stoichiometry: 5.0
species: 867216

917839
type: SpeciesReference
stoichiometry: 4.0
species: 867818

865134
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 4-Aminobutanoate

882447
type: Reaction
reactant: 882471
kinetic law: 882507
name: acyl-coA cholesterol acyltransferase, Hepatocyte
fast: false
notes: GENE_ASSOCIATION: (NM_003101.4 or (NM_003101.4 and NM_003578.3) or NM_003578.3) GENE_LIST: NM_003101.4 NM_003578.3 SUBSYSTEM: Cholesterol Metabolism
product: 882483
reversible: false
reactant: 882459
product: 882495

882471
type: SpeciesReference
stoichiometry: 0.001
species: 866780

882557
type: LocalParameter
value: 500.0

882545
type: LocalParameter
value: 0.0

882533
type: LocalParameter
value: 1000.0

882520
type: LocalParameter
value: 0.0

882483
type: SpeciesReference
stoichiometry: 0.001
species: 865799

882459
type: SpeciesReference
stoichiometry: 1.0
species: 865811

882495
type: SpeciesReference
stoichiometry: 1.0
species: 865883

872703
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: pnto_R_b

932621
type: Reaction
reactant: 932646
kinetic law: 932682
name: glutamate decarboxylase
product: 932670
reversible: false
product: 932658
fast: false
reactant: 932633
notes: GENE_ASSOCIATION: (NM_000817.2 or NM_013445.3 or NM_000818.1) GENE_LIST: NM_000817.2 NM_000818.1 NM_013445.3 SUBSYSTEM: Valine degradation

932646
type: SpeciesReference
stoichiometry: 1.0
species: 867216

932730
type: LocalParameter
value: 500.0

932718
type: LocalParameter
value: 0.0

932706
type: LocalParameter
value: 1000.0

932694
type: LocalParameter
value: 0.0

932670
type: SpeciesReference
stoichiometry: 1.0
species: 865871

932658
type: SpeciesReference
stoichiometry: 1.0
species: 865134

932633
type: SpeciesReference
stoichiometry: 1.0
species: 867059

871529
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 7 alpha-Hydroxycholesterol

941178
type: Reaction
product: 941226
product: 941250
reversible: false
fast: false
reactant: 941190
kinetic law: 941262
notes: GENE_ASSOCIATION: (NM_000884.2 or NM_000883.2 or NM_183243.1 or NM_001102605.1) GENE_LIST: NM_000883.2 NM_000884.2 NM_001102605.1 NM_183243.1 SUBSYSTEM: Nucleotides
reactant: 941202
reactant: 941214
name: IMP dehydrogenase
product: 941238

941226
type: SpeciesReference
stoichiometry: 1.0
species: 867216

941250
type: SpeciesReference
stoichiometry: 1.0
species: 869012

869012
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Xanthosine 5'-phosphate

941190
type: SpeciesReference
stoichiometry: 1.0
species: 867228

941310
type: LocalParameter
value: 500.0

941298
type: LocalParameter
value: 0.0

941286
type: LocalParameter
value: 1000.0

941274
type: LocalParameter
value: 0.0

941202
type: SpeciesReference
stoichiometry: 1.0
species: 867504

867504
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: IMP

941214
type: SpeciesReference
stoichiometry: 1.0
species: 867794

941238
type: SpeciesReference
stoichiometry: 1.0
species: 867806

877071
type: Reaction
kinetic law: 877107
product: 877095
reactant: 877083
fast: false
reversible: true
name: heptadecanoate (C17:0) exchange

877155
type: LocalParameter
value: 500.0

877143
type: LocalParameter
value: 0.0

877131
type: LocalParameter
value: 1000.0

877119
type: LocalParameter
value: 0.0

877095
type: SpeciesReference
stoichiometry: 1.0
species: 872459

877083
type: SpeciesReference
stoichiometry: 1.0
species: 864479

930643
type: Reaction
reversible: false
fast: false
kinetic law: 930715
product: 930691
product: 930703
product: 930679
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 930655
reactant: 930667
name: phosphoribosylglycinamide formyltransferase, irreversible

930764
type: LocalParameter
value: 500.0

930751
type: LocalParameter
value: 0.0

930739
type: LocalParameter
value: 1000.0

930727
type: LocalParameter
value: 0.0

930691
type: SpeciesReference
stoichiometry: 1.0
species: 867216

930703
type: SpeciesReference
stoichiometry: 1.0
species: 868758

930679
type: SpeciesReference
stoichiometry: 1.0
species: 866828

866828
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide

930655
type: SpeciesReference
stoichiometry: 1.0
species: 864881

930667
type: SpeciesReference
stoichiometry: 1.0
species: 866999

946084
type: Reaction
kinetic law: 946121
product: 946108
reactant: 946096
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: mevalonate transport, peroxisome

946169
type: LocalParameter
value: 0.0

946157
type: LocalParameter
value: 0.0

946145
type: LocalParameter
value: 1000.0

946133
type: LocalParameter
value: -1000.0

946108
type: SpeciesReference
stoichiometry: 1.0
species: 867710

867710
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: (R)-Mevalonate

946096
type: SpeciesReference
stoichiometry: 1.0
species: 871869

872778
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: thr_L_b

947027
type: Reaction
kinetic law: 947063
product: 947051
reactant: 947039
notes: GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
fast: false
reversible: true
name: methylmalonyl-CoA epimerase, mitochondrial

947112
type: LocalParameter
value: 0.0

947099
type: LocalParameter
value: 0.0

947087
type: LocalParameter
value: 1000.0

947075
type: LocalParameter
value: -1000.0

947051
type: SpeciesReference
stoichiometry: 1.0
species: 870421

870421
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (R)-Methylmalonyl-CoA

947039
type: SpeciesReference
stoichiometry: 1.0
species: 870434

940501
type: Reaction
notes: GENE_ASSOCIATION: NM_002168.2 GENE_LIST: NM_002168.2 SUBSYSTEM: Citric Acid Cycle
product: 940561
reactant: 940513
kinetic law: 940573
name: Isocitrate dehydrogenase (NADP+)
product: 940549
reversible: false
reactant: 940525
fast: false
product: 940537

940561
type: SpeciesReference
stoichiometry: 1.0
species: 870487

940513
type: SpeciesReference
stoichiometry: 1.0
species: 870299

940621
type: LocalParameter
value: 500.0

940609
type: LocalParameter
value: 0.0

940597
type: LocalParameter
value: 1000.0

940585
type: LocalParameter
value: 0.0

940549
type: SpeciesReference
stoichiometry: 1.0
species: 869631

940525
type: SpeciesReference
stoichiometry: 1.0
species: 870474

940537
type: SpeciesReference
stoichiometry: 1.0
species: 869448

913302
type: Reaction
reactant: 913338
product: 913362
reactant: 913326
fast: false
kinetic law: 913386
product: 913374
reactant: 913314
product: 913350
reversible: true
name: fatty-acid--CoA ligase (tetradecanoate)
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203379.1 or NM_015256.2 or NM_022977.1 or NM_016234.3 or NM_001009185.1 or NM_004458.1 or NM_203380.1 or NM_004457.3) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis

913338
type: SpeciesReference
stoichiometry: 1.0
species: 868854

913362
type: SpeciesReference
stoichiometry: 1.0
species: 868361

913326
type: SpeciesReference
stoichiometry: 1.0
species: 865883

913435
type: LocalParameter
value: 0.0

913423
type: LocalParameter
value: 0.0

913410
type: LocalParameter
value: 1000.0

913398
type: LocalParameter
value: -1000.0

913374
type: SpeciesReference
stoichiometry: 1.0
species: 868686

913314
type: SpeciesReference
stoichiometry: 1.0
species: 865641

913350
type: SpeciesReference
stoichiometry: 1.0
species: 865568

928126
type: Reaction
product: 928186
reactant: 928138
name: formate-tetrahydrofolate ligase
reversible: true
notes: SUBSYSTEM: Vitamins & Cofactor Biosynthesis
kinetic law: 928210
reactant: 928150
fast: false
reactant: 928162
product: 928198
product: 928174

928186
type: SpeciesReference
stoichiometry: 1.0
species: 865460

928138
type: SpeciesReference
stoichiometry: 1.0
species: 865641

928258
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value: 0.0

928246
type: LocalParameter
value: 0.0

928234
type: LocalParameter
value: 1000.0

928222
type: LocalParameter
value: -1000.0

928150
type: SpeciesReference
stoichiometry: 1.0
species: 866852

928162
type: SpeciesReference
stoichiometry: 1.0
species: 868758

928198
type: SpeciesReference
stoichiometry: 1.0
species: 868265

928174
type: SpeciesReference
stoichiometry: 1.0
species: 864881

940756
type: Reaction
reactant: 940768
kinetic law: 940817
name: isoleucine transaminase, mitochondrial
reversible: true
product: 940805
product: 940793
reactant: 940780
notes: GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
fast: false

940768
type: SpeciesReference
stoichiometry: 1.0
species: 869448

940865
type: LocalParameter
value: 0.0

940853
type: LocalParameter
value: 0.0

940841
type: LocalParameter
value: 1000.0

940829
type: LocalParameter
value: -1000.0

940805
type: SpeciesReference
stoichiometry: 1.0
species: 870055

940793
type: SpeciesReference
stoichiometry: 1.0
species: 869290

869290
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-3-Methyl-2-oxopentanoate

940780
type: SpeciesReference
stoichiometry: 1.0
species: 870311

870311
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Isoleucine

880088
type: Reaction
kinetic law: 880126
product: 880114
reactant: 880101
fast: false
reversible: true
name: Urea exchange

880175
type: LocalParameter
value: 500.0

880163
type: LocalParameter
value: 0.0

880150
type: LocalParameter
value: 1000.0

880138
type: LocalParameter
value: 0.0

880114
type: SpeciesReference
stoichiometry: 1.0
species: 872840

872840
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: urea_b

880101
type: SpeciesReference
stoichiometry: 1.0
species: 864857

864857
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Urea

940974
type: Reaction
kinetic law: 941010
product: 940998
reactant: 940986
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Isoleucine mitochondrial transport

941058
type: LocalParameter
value: 0.0

941046
type: LocalParameter
value: 0.0

941034
type: LocalParameter
value: 1000.0

941022
type: LocalParameter
value: -1000.0

940998
type: SpeciesReference
stoichiometry: 1.0
species: 870311

940986
type: SpeciesReference
stoichiometry: 1.0
species: 867468

966915
type: Reaction
kinetic law: 966951
product: 966939
reactant: 966927
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: taurine transport, uniport (cytosol to peroxisome)

966999
type: LocalParameter
value: 0.0

966987
type: LocalParameter
value: 0.0

966975
type: LocalParameter
value: 1000.0

966963
type: LocalParameter
value: -1000.0

966939
type: SpeciesReference
stoichiometry: 1.0
species: 871990

966927
type: SpeciesReference
stoichiometry: 1.0
species: 868661

868661
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Taurine

867988
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octanoate

917911
type: Reaction
reactant: 917959
product: 917995
reactant: 917947
notes: SUBSYSTEM: Fatty Acid Synthesis
product: 918007
reactant: 917971
name: fatty-acyl-CoA elongation (C22:4CoA, n6)
product: 917983
reactant: 917935
product: 918019
reversible: false
reactant: 917923
kinetic law: 918043
product: 918031
fast: false

917959
type: SpeciesReference
stoichiometry: 4.0
species: 867830

917995
type: SpeciesReference
stoichiometry: 1.0
species: 865883

917947
type: SpeciesReference
stoichiometry: 1.0
species: 867638

918007
type: SpeciesReference
stoichiometry: 3.0
species: 867228

917971
type: SpeciesReference
stoichiometry: 1.0
species: 867854

917983
type: SpeciesReference
stoichiometry: 1.0
species: 865871

917935
type: SpeciesReference
stoichiometry: 5.0
species: 867216

918019
type: SpeciesReference
stoichiometry: 4.0
species: 867818

917923
type: SpeciesReference
stoichiometry: 1.0
species: 866707

918091
type: LocalParameter
value: 500.0

918079
type: LocalParameter
value: 0.0

918067
type: LocalParameter
value: 1000.0

918055
type: LocalParameter
value: 0.0

918031
type: SpeciesReference
stoichiometry: 1.0
species: 868109

867650
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Mannose

877955
type: Reaction
kinetic law: 877991
product: 877979
reactant: 877967
fast: false
reversible: true
name: Ammonium exchange

878039
type: LocalParameter
value: 0.0

878027
type: LocalParameter
value: 0.0

878015
type: LocalParameter
value: 1000.0

878003
type: LocalParameter
value: -1000.0

877979
type: SpeciesReference
stoichiometry: 1.0
species: 872569

877967
type: SpeciesReference
stoichiometry: 1.0
species: 864589

869727
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: docosahexaenoyl carnitine (C22:6Crn, n-3)

942183
type: Reaction
reactant: 942195
product: 942256
fast: false
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
kinetic law: 942280
reactant: 942220
product: 942268
reactant: 942232
reversible: false
reactant: 942208
name: lathosterol oxidase (NAD), endoplasmic reticulum
product: 942244

942195
type: SpeciesReference
stoichiometry: 1.0
species: 871385

942256
type: SpeciesReference
stoichiometry: 2.0
species: 871397

942328
type: LocalParameter
value: 500.0

942316
type: LocalParameter
value: 0.0

942304
type: LocalParameter
value: 1000.0

942292
type: LocalParameter
value: 0.0

942220
type: SpeciesReference
stoichiometry: 1.0
species: 871445

942268
type: SpeciesReference
stoichiometry: 1.0
species: 871433

942232
type: SpeciesReference
stoichiometry: 1.0
species: 871481

942208
type: SpeciesReference
stoichiometry: 1.0
species: 871421

942244
type: SpeciesReference
stoichiometry: 1.0
species: 871251

924196
type: Reaction
reactant: 924245
reactant: 924233
reactant: 924208
reversible: false
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
name: fatty acid synthase (n-C10:0)
product: 924294
product: 924282
reactant: 924221
kinetic law: 924318
product: 924269
fast: false
product: 924257
product: 924306

924245
type: SpeciesReference
stoichiometry: 1.0
species: 867988

924233
type: SpeciesReference
stoichiometry: 2.0
species: 867830

924208
type: SpeciesReference
stoichiometry: 3.0
species: 867216

924294
type: SpeciesReference
stoichiometry: 1.0
species: 867228

924282
type: SpeciesReference
stoichiometry: 1.0
species: 866003

866003
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Decanoate

924221
type: SpeciesReference
stoichiometry: 1.0
species: 867638

924366
type: LocalParameter
value: 500.0

924354
type: LocalParameter
value: 0.0

924342
type: LocalParameter
value: 1000.0

924330
type: LocalParameter
value: 0.0

924269
type: SpeciesReference
stoichiometry: 1.0
species: 865883

924257
type: SpeciesReference
stoichiometry: 1.0
species: 865871

924306
type: SpeciesReference
stoichiometry: 2.0
species: 867818

895473
type: Reaction
kinetic law: 895509
product: 895497
reactant: 895485
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: CO2 transport out via diffusion

895557
type: LocalParameter
value: 0.0

895545
type: LocalParameter
value: 0.0

895533
type: LocalParameter
value: 1000.0

895521
type: LocalParameter
value: -1000.0

895497
type: SpeciesReference
stoichiometry: 1.0
species: 865871

895485
type: SpeciesReference
stoichiometry: 1.0
species: 864138

864138
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: CO2

900238
type: Reaction
reactant: 900262
kinetic law: 900298
reversible: true
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 900274
fast: false
product: 900286
reactant: 900250
name: carnitine pentadecanoyltransferase (C17:0CoA), mitochondrial

900262
type: SpeciesReference
stoichiometry: 1.0
species: 870251

870251
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: heptadecanoyl CoA (C17:0CoA)

900346
type: LocalParameter
value: 0.0

900334
type: LocalParameter
value: 0.0

900322
type: LocalParameter
value: 1000.0

900310
type: LocalParameter
value: -1000.0

900274
type: SpeciesReference
stoichiometry: 1.0
species: 869643

900286
type: SpeciesReference
stoichiometry: 1.0
species: 870263

900250
type: SpeciesReference
stoichiometry: 1.0
species: 869655

873684
type: Reaction
kinetic law: 873721
product: 873708
reactant: 873696
fast: false
reversible: true
name: Acetoacetate exchange

873769
type: LocalParameter
value: 500.0

873757
type: LocalParameter
value: 0.0

873745
type: LocalParameter
value: 1000.0

873733
type: LocalParameter
value: 0.0

873708
type: SpeciesReference
stoichiometry: 1.0
species: 872038

873696
type: SpeciesReference
stoichiometry: 1.0
species: 864054

864054
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Acetoacetate

868601
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Spermidine

967107
type: Reaction
kinetic law: 967144
product: 967131
reactant: 967119
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: lipid, flip-flop intracellular transport

967192
type: LocalParameter
value: 0.0

967180
type: LocalParameter
value: 0.0

967168
type: LocalParameter
value: 1000.0

967156
type: LocalParameter
value: -1000.0

967131
type: SpeciesReference
stoichiometry: 1.0
species: 872002

872002
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

967119
type: SpeciesReference
stoichiometry: 1.0
species: 868746

868746
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

957748
type: Reaction
product: 957894
fast: false
product: 957954
kinetic law: 958075
product: 958014
product: 958051
product: 957809
product: 957869
reactant: 957761
product: 957833
product: 957797
product: 957918
product: 957978
product: 957882
reactant: 957773
product: 957942
product: 957857
product: 958039
product: 958002
product: 957785
notes: GENE_ASSOCIATION: (NM_178034.2 or NM_030821.3 or NM_003560.2 or NM_001004426.1 or NM_024420.1 or NM_003706.1 or NM_213600.2 or NM_001080490.1) GENE_LIST: NM_001004426.1 NM_001080490.1 NM_003560.2 NM_003706.1 NM_024420.1 NM_030821.3 NM_178034.2 NM_213600.2 SUBSYSTEM: Glycerophospholipid Metabolism
product: 957821
product: 958063
product: 957906
product: 958026
product: 957966
reversible: false
product: 957930
name: Phospholipase A (phosphatidylcholine), hepatocyte
product: 957990
product: 957845

957894
type: SpeciesReference
stoichiometry: 0.001
species: 866536

957954
type: SpeciesReference
stoichiometry: 0.001
species: 867396

958123
type: LocalParameter
value: 500.0

958111
type: LocalParameter
value: 0.0

958099
type: LocalParameter
value: 1000.0

958087
type: LocalParameter
value: 0.0

958014
type: SpeciesReference
stoichiometry: 0.124
species: 867940

958051
type: SpeciesReference
stoichiometry: 0.034
species: 868854

957809
type: SpeciesReference
stoichiometry: 0.002
species: 866101

957869
type: SpeciesReference
stoichiometry: 0.001
species: 866512

957761
type: SpeciesReference
stoichiometry: 1.0
species: 867228

957833
type: SpeciesReference
stoichiometry: 0.013
species: 866149

957797
type: SpeciesReference
stoichiometry: 0.005
species: 866088

957918
type: SpeciesReference
stoichiometry: 1.0
species: 867216

957978
type: SpeciesReference
stoichiometry: 0.285
species: 867903

957882
type: SpeciesReference
stoichiometry: 0.004
species: 866524

957773
type: SpeciesReference
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species: 868157

957942
type: SpeciesReference
stoichiometry: 0.06
species: 867288

957857
type: SpeciesReference
stoichiometry: 0.003
species: 866500

958039
type: SpeciesReference
stoichiometry: 0.003
species: 868469

958002
type: SpeciesReference
stoichiometry: 0.001
species: 867928

957785
type: SpeciesReference
stoichiometry: 0.001
species: 864929

957821
type: SpeciesReference
stoichiometry: 0.002
species: 866113

958063
type: SpeciesReference
stoichiometry: 0.001
species: 868867

957906
type: SpeciesReference
stoichiometry: 0.027
species: 866561

958026
type: SpeciesReference
stoichiometry: 0.002
species: 867976

957966
type: SpeciesReference
stoichiometry: 0.073
species: 867891

957930
type: SpeciesReference
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species: 867276

957990
type: SpeciesReference
stoichiometry: 0.002
species: 867915

957845
type: SpeciesReference
stoichiometry: 0.001
species: 866452

871785
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: FADH2

956677
type: Reaction
reactant: 956689
kinetic law: 956761
name: phenylalanine 4-monooxygenase
notes: GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine metabolism
fast: false
product: 956725
reactant: 956701
reversible: false
product: 956737
reactant: 956713
product: 956749

956689
type: SpeciesReference
stoichiometry: 1.0
species: 867854

956810
type: LocalParameter
value: 500.0

956798
type: LocalParameter
value: 0.0

956786
type: LocalParameter
value: 1000.0

956773
type: LocalParameter
value: 0.0

956725
type: SpeciesReference
stoichiometry: 1.0
species: 866222

866222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 6,7-Dihydrobiopterin

956701
type: SpeciesReference
stoichiometry: 1.0
species: 868229

956737
type: SpeciesReference
stoichiometry: 1.0
species: 867228

956713
type: SpeciesReference
stoichiometry: 1.0
species: 868734

868734
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Tetrahydrobiopterin

956749
type: SpeciesReference
stoichiometry: 1.0
species: 868879

876685
type: Reaction
kinetic law: 876721
product: 876709
reactant: 876697
fast: false
reversible: true
name: Bicarbonate exchange

876769
type: LocalParameter
value: 500.0

876757
type: LocalParameter
value: 0.0

876745
type: LocalParameter
value: 1000.0

876733
type: LocalParameter
value: 0.0

876709
type: SpeciesReference
stoichiometry: 1.0
species: 872411

876697
type: SpeciesReference
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species: 864430

903489
type: Reaction
kinetic law: 903549
product: 903537
name: Palmitoylcarnitine shuttle (C16:0Crn), mitochondrial
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reactant: 903513
product: 903525
reactant: 903501
fast: false
reversible: true

903597
type: LocalParameter
value: 0.0

903585
type: LocalParameter
value: 0.0

903573
type: LocalParameter
value: 1000.0

903561
type: LocalParameter
value: -1000.0

903537
type: SpeciesReference
stoichiometry: 1.0
species: 870827

903513
type: SpeciesReference
stoichiometry: 1.0
species: 869655

903525
type: SpeciesReference
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species: 865907

903501
type: SpeciesReference
stoichiometry: 1.0
species: 868301

956459
type: Reaction
kinetic law: 956495
product: 956483
reactant: 956471
notes: GENE_ASSOCIATION: (NM_002633.2 or NM_018290.2) GENE_LIST: NM_002633.2 NM_018290.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: phosphoglucomutase

956543
type: LocalParameter
value: 0.0

956531
type: LocalParameter
value: 0.0

956519
type: LocalParameter
value: 1000.0

956507
type: LocalParameter
value: -1000.0

956483
type: SpeciesReference
stoichiometry: 1.0
species: 866962

956471
type: SpeciesReference
stoichiometry: 1.0
species: 866937

887087
type: Reaction
reactant: 887099
reactant: 887111
product: 887123
reversible: true
notes: GENE_ASSOCIATION: (NM_133443.1 or NM_005309.1) GENE_LIST: NM_005309.1 NM_133443.1 SUBSYSTEM: Alanine and Aspartate Metabolism
fast: false
name: L-alanine transaminase
product: 887135
kinetic law: 887147

887099
type: SpeciesReference
stoichiometry: 1.0
species: 865520

887111
type: SpeciesReference
stoichiometry: 1.0
species: 865532

887123
type: SpeciesReference
stoichiometry: 1.0
species: 867059

887135
type: SpeciesReference
stoichiometry: 1.0
species: 868493

887196
type: LocalParameter
value: 0.0

887183
type: LocalParameter
value: 0.0

887171
type: LocalParameter
value: 1000.0

887159
type: LocalParameter
value: -1000.0

950925
type: Reaction
kinetic law: 950986
reactant: 950950
product: 950974
fast: false
notes: GENE_ASSOCIATION: (NM_001002006.1 or NM_033253.2 or NM_012229.2) GENE_LIST: NM_001002006.1 NM_012229.2 NM_033253.2 SUBSYSTEM: Nucleotides
reactant: 950938
name: 5'-nucleotidase (AMP)
reversible: false
product: 950962

951034
type: LocalParameter
value: 500.0

951022
type: LocalParameter
value: 0.0

951010
type: LocalParameter
value: 1000.0

950998
type: LocalParameter
value: 0.0

950950
type: SpeciesReference
stoichiometry: 1.0
species: 867228

950974
type: SpeciesReference
stoichiometry: 1.0
species: 868265

950938
type: SpeciesReference
stoichiometry: 1.0
species: 865568

950962
type: SpeciesReference
stoichiometry: 1.0
species: 865448

871977
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Sarcosine

930137
type: Reaction
product: 930185
reactant: 930161
kinetic law: 930209
reactant: 930149
product: 930197
product: 930173
reversible: false
fast: false
notes: GENE_ASSOCIATION: (NM_000154.1 or NM_002044.2 or NM_001001556.1) GENE_LIST: NM_000154.1 NM_001001556.1 NM_002044.2 SUBSYSTEM: Galactose Metabolism
name: galactokinase

930185
type: SpeciesReference
stoichiometry: 1.0
species: 866987

866987
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: alpha-D-Galactose 1-phosphate

930161
type: SpeciesReference
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species: 866974

866974
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Galactose

930257
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value: 500.0

930245
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value: 0.0

930233
type: LocalParameter
value: 1000.0

930221
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value: 0.0

930149
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stoichiometry: 1.0
species: 865641

930197
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species: 867216

930173
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stoichiometry: 1.0
species: 865460

927788
type: Reaction
kinetic law: 927824
product: 927812
reactant: 927800
notes: SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: Farnesyl diphosphate transport

927873
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927860
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value: 0.0

927848
type: LocalParameter
value: 1000.0

927836
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value: -1000.0

927812
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stoichiometry: 1.0
species: 871349

927800
type: SpeciesReference
stoichiometry: 1.0
species: 866900

955998
type: Reaction
reactant: 956022
product: 956034
reactant: 956010
fast: false
name: phosphoglycerate kinase
notes: GENE_ASSOCIATION: (NM_138733.2 or NM_000291.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 956046
kinetic law: 956058
reversible: true

956022
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stoichiometry: 1.0
species: 865460

956034
type: SpeciesReference
stoichiometry: 1.0
species: 865098

956010
type: SpeciesReference
stoichiometry: 1.0
species: 864905

956046
type: SpeciesReference
stoichiometry: 1.0
species: 865641

956106
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value: 0.0

956094
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value: 0.0

956082
type: LocalParameter
value: 1000.0

956070
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value: -1000.0

952296
type: Reaction
kinetic law: 952356
name: orotidine-5'-phosphate decarboxylase
reversible: false
notes: GENE_ASSOCIATION: NM_000373.1 GENE_LIST: NM_000373.1 SUBSYSTEM: Pyrimidine Biosynthesis
reactant: 952308
fast: false
reactant: 952320
product: 952332
product: 952344

952404
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value: 500.0

952392
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value: 0.0

952380
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value: 1000.0

952368
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952308
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stoichiometry: 1.0
species: 867216

952320
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species: 868097

868097
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Orotidine 5'-phosphate

952332
type: SpeciesReference
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species: 865871

952344
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species: 868927

876201
type: Reaction
kinetic law: 876237
product: 876225
reactant: 876213
fast: false
reversible: true
name: L-Glutamate exchange

876286
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value: 500.0

876274
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value: 0.0

876262
type: LocalParameter
value: 1000.0

876249
type: LocalParameter
value: 0.0

876225
type: SpeciesReference
stoichiometry: 1.0
species: 872351

876213
type: SpeciesReference
stoichiometry: 1.0
species: 864369

864369
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Glutamate

911849
type: Reaction
kinetic law: 911885
product: 911873
reactant: 911861
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase

911934
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value: 0.0

911921
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value: 0.0

911909
type: LocalParameter
value: 1000.0

911897
type: LocalParameter
value: -1000.0

911873
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stoichiometry: 1.0
species: 871421

911861
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stoichiometry: 1.0
species: 871592

871592
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Zymostenol

877267
type: Reaction
kinetic law: 877306
product: 877293
reactant: 877280
fast: false
reversible: true
name: D-Lactate exchange

877358
type: LocalParameter
value: 500.0

877345
type: LocalParameter
value: 0.0

877332
type: LocalParameter
value: 1000.0

877319
type: LocalParameter
value: 0.0

877293
type: SpeciesReference
stoichiometry: 1.0
species: 872483

877280
type: SpeciesReference
stoichiometry: 1.0
species: 864503

960343
type: Reaction
reactant: 960355
reversible: false
product: 960379
product: 960391
notes: GENE_ASSOCIATION: (NM_000819.3 or NM_175085.1) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
reactant: 960367
fast: false
product: 960403
name: phosphoribosylaminoimidazole synthetase
kinetic law: 960427
product: 960415

960355
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species: 865641

960379
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species: 865460

960391
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species: 865508

960367
type: SpeciesReference
stoichiometry: 1.0
species: 866876

866876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine

960403
type: SpeciesReference
stoichiometry: 1.0
species: 867216

960475
type: LocalParameter
value: 500.0

960463
type: LocalParameter
value: 0.0

960451
type: LocalParameter
value: 1000.0

960439
type: LocalParameter
value: 0.0

960415
type: SpeciesReference
stoichiometry: 1.0
species: 868265

904090
type: Reaction
name: carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
fast: false
product: 904129
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 904142
reactant: 904116
kinetic law: 904155
reversible: true
reactant: 904103

904129
type: SpeciesReference
stoichiometry: 1.0
species: 869655

904142
type: SpeciesReference
stoichiometry: 1.0
species: 871021

904116
type: SpeciesReference
stoichiometry: 1.0
species: 871034

871034
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: tetradecanoylcarnitine (C14:0Crn)

904207
type: LocalParameter
value: 0.0

904194
type: LocalParameter
value: 0.0

904181
type: LocalParameter
value: 1000.0

904168
type: LocalParameter
value: -1000.0

904103
type: SpeciesReference
stoichiometry: 1.0
species: 869643

943686
type: Reaction
reactant: 943710
kinetic law: 943746
reactant: 943698
notes: GENE_ASSOCIATION: (NM_014252.2 or NM_031947.2) GENE_LIST: NM_014252.2 NM_031947.2 SUBSYSTEM: Transport, Mitochondrial
product: 943722
fast: false
reversible: true
product: 943734
name: Lysine mitochondrial transport via ornithine carrier

943710
type: SpeciesReference
stoichiometry: 1.0
species: 870140

943794
type: LocalParameter
value: 0.0

943782
type: LocalParameter
value: 0.0

943770
type: LocalParameter
value: 1000.0

943758
type: LocalParameter
value: -1000.0

943698
type: SpeciesReference
stoichiometry: 1.0
species: 867614

943722
type: SpeciesReference
stoichiometry: 1.0
species: 867216

943734
type: SpeciesReference
stoichiometry: 1.0
species: 870347

864151
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Cysteine

956918
type: Reaction
fast: false
reactant: 956942
reactant: 956930
product: 956955
reversible: true
kinetic law: 956979
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Phenylalanine metabolism
product: 956967
name: phenylalanine transaminase

956942
type: SpeciesReference
stoichiometry: 1.0
species: 868229

956930
type: SpeciesReference
stoichiometry: 1.0
species: 865520

956955
type: SpeciesReference
stoichiometry: 1.0
species: 867059

957027
type: LocalParameter
value: 0.0

957015
type: LocalParameter
value: 0.0

957003
type: LocalParameter
value: 1000.0

956991
type: LocalParameter
value: -1000.0

956967
type: SpeciesReference
stoichiometry: 1.0
species: 868253

868253
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Phenylpyruvate

904581
type: Reaction
fast: false
reactant: 904605
name: carnitine O-acetyltransferase
product: 904629
product: 904617
kinetic law: 904641
reversible: true
reactant: 904593
notes: SUBSYSTEM: Transport, Mitochondrial

904605
type: SpeciesReference
stoichiometry: 1.0
species: 865907

904629
type: SpeciesReference
stoichiometry: 1.0
species: 869655

904617
type: SpeciesReference
stoichiometry: 1.0
species: 869424

869424
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: O-Acetylcarnitine

904689
type: LocalParameter
value: 0.0

904677
type: LocalParameter
value: 0.0

904665
type: LocalParameter
value: 1000.0

904653
type: LocalParameter
value: -1000.0

904593
type: SpeciesReference
stoichiometry: 1.0
species: 865436

869872
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosatrienoyl-CoA (C20:3CoA, n-6)

884570
type: Reaction
reactant: 884594
product: 884618
name: adenosylmethionine decarboxylase
notes: GENE_ASSOCIATION: (NM_001634.4 or NM_001033059.1) GENE_LIST: NM_001033059.1 NM_001634.4 SUBSYSTEM: Arginine and Proline Metabolism
kinetic law: 884630
fast: false
reactant: 884582
product: 884606
reversible: false

884594
type: SpeciesReference
stoichiometry: 1.0
species: 867216

884618
type: SpeciesReference
stoichiometry: 1.0
species: 865871

884678
type: LocalParameter
value: 500.0

884666
type: LocalParameter
value: 0.0

884654
type: LocalParameter
value: 1000.0

884642
type: LocalParameter
value: 0.0

884582
type: SpeciesReference
stoichiometry: 1.0
species: 865544

884606
type: SpeciesReference
stoichiometry: 1.0
species: 865556

865556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: S-Adenosylmethioninamine

865835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Citrulline

872182
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ddca_b

882205
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_003051.3 or NM_004696.1 or NM_001042423.1 or NM_001042422.1 or NM_004207.1 or NM_004694.2 or NM_004731.3 or NM_013356.1 or NM_004695.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular
reversible: true
kinetic law: 882266
reactant: 882229
product: 882254
product: 882241
reactant: 882217
name: acetoacetate transport via proton symport, blood

882315
type: LocalParameter
value: 0.0

882303
type: LocalParameter
value: 0.0

882291
type: LocalParameter
value: 1000.0

882279
type: LocalParameter
value: -1000.0

882229
type: SpeciesReference
stoichiometry: 1.0
species: 864405

882254
type: SpeciesReference
stoichiometry: 1.0
species: 867216

882241
type: SpeciesReference
stoichiometry: 1.0
species: 865388

882217
type: SpeciesReference
stoichiometry: 1.0
species: 864054

943927
type: Reaction
fast: false
name: malate oxaloacetate shuttle, mitochondrial
reactant: 943939
notes: SUBSYSTEM: Transport, Mitochondrial
product: 943963
kinetic law: 943987
reactant: 943951
product: 943975
reversible: true

943939
type: SpeciesReference
stoichiometry: 1.0
species: 867879

943963
type: SpeciesReference
stoichiometry: 1.0
species: 867626

867626
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: L-Malate

944035
type: LocalParameter
value: 0.0

944023
type: LocalParameter
value: 0.0

944011
type: LocalParameter
value: 1000.0

943999
type: LocalParameter
value: -1000.0

943951
type: SpeciesReference
stoichiometry: 1.0
species: 870359

943975
type: SpeciesReference
stoichiometry: 1.0
species: 870551

949043
type: Reaction
reactant: 949067
kinetic law: 949103
product: 949091
product: 949079
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: 949055
fast: false
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_002512.2) or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_002512.2 and NM_198175.1) or NM_197972.1 or NM_013330.3 or NM_005793.3 or (NM_000269.2 and NM_001018137.1) or (NM_001018137.1 and NM_198175.1) or NM_002513.2 or (NM_001018139.1 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotides
reversible: true

949067
type: SpeciesReference
stoichiometry: 1.0
species: 868891

949151
type: LocalParameter
value: 0.0

949139
type: LocalParameter
value: 0.0

949127
type: LocalParameter
value: 1000.0

949115
type: LocalParameter
value: -1000.0

949091
type: SpeciesReference
stoichiometry: 1.0
species: 868988

949079
type: SpeciesReference
stoichiometry: 1.0
species: 865460

949055
type: SpeciesReference
stoichiometry: 1.0
species: 865641

887714
type: Reaction
notes: GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Pyruvate Metabolism
fast: false
product: 887762
kinetic law: 887798
reversible: false
name: aldehyde dehydrogenase (acetaldehyde, NAD)
reactant: 887738
reactant: 887726
product: 887786
reactant: 887750
product: 887774

887762
type: SpeciesReference
stoichiometry: 1.0
species: 865375

887847
type: LocalParameter
value: 500.0

887835
type: LocalParameter
value: 0.0

887822
type: LocalParameter
value: 1000.0

887810
type: LocalParameter
value: 0.0

887738
type: SpeciesReference
stoichiometry: 1.0
species: 867228

887726
type: SpeciesReference
stoichiometry: 1.0
species: 865400

865400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Acetaldehyde

887786
type: SpeciesReference
stoichiometry: 1.0
species: 867806

887750
type: SpeciesReference
stoichiometry: 1.0
species: 867794

887774
type: SpeciesReference
stoichiometry: 2.0
species: 867216

934855
type: Reaction
product: 934964
notes: GENE_ASSOCIATION: NM_003875.2 GENE_LIST: NM_003875.2 SUBSYSTEM: Nucleotides
reactant: 934879
product: 934928
fast: false
reactant: 934903
product: 934916
reversible: false
reactant: 934891
name: GMP synthase (glutamine-hydrolysing)
product: 934940
reactant: 934867
product: 934952
kinetic law: 934976

934964
type: SpeciesReference
stoichiometry: 1.0
species: 868361

934879
type: SpeciesReference
stoichiometry: 1.0
species: 867047

934928
type: SpeciesReference
stoichiometry: 1.0
species: 867059

934903
type: SpeciesReference
stoichiometry: 1.0
species: 869012

934916
type: SpeciesReference
stoichiometry: 1.0
species: 865568

934891
type: SpeciesReference
stoichiometry: 1.0
species: 867228

934940
type: SpeciesReference
stoichiometry: 1.0
species: 867155

867155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: GMP

934867
type: SpeciesReference
stoichiometry: 1.0
species: 865641

934952
type: SpeciesReference
stoichiometry: 2.0
species: 867216

935024
type: LocalParameter
value: 500.0

935012
type: LocalParameter
value: 0.0

935000
type: LocalParameter
value: 1000.0

934988
type: LocalParameter
value: 0.0

870611
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecatrienoyl-CoA (C18:3CoA, n-6)

931754
type: Reaction
kinetic law: 931791
product: 931779
reactant: 931766
notes: GENE_ASSOCIATION: (NM_014580.3 or NM_030807.2 or NM_001024938.1 or NM_006931.1 or NM_207420.1 or NM_153449.2 or NM_145176.2 or NM_020041.2 or NM_000340.1 or NM_030777.3 or NM_001024939.1 or NM_001001290.1 or NM_006516.1 or NM_001042.2 or NM_017585.2) GENE_LIST: NM_000340.1 NM_001001290.1 NM_001024938.1 NM_001024939.1 NM_001042.2 NM_006516.1 NM_006931.1 NM_014580.3 NM_017585.2 NM_020041.2 NM_030777.3 NM_030807.2 NM_145176.2 NM_153449.2 NM_207420.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: glucose transport (uniport: facilitated diffusion)

931839
type: LocalParameter
value: 0.0

931827
type: LocalParameter
value: 0.0

931815
type: LocalParameter
value: 1000.0

931803
type: LocalParameter
value: -1000.0

931779
type: SpeciesReference
stoichiometry: 1.0
species: 867035

931766
type: SpeciesReference
stoichiometry: 1.0
species: 864345

864345
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: D-Glucose

916789
type: Reaction
reactant: 916813
fast: false
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
reversible: true
product: 916861
name: fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
reactant: 916825
product: 916849
product: 916837
kinetic law: 916873
reactant: 916801

916813
type: SpeciesReference
stoichiometry: 1.0
species: 865883

916861
type: SpeciesReference
stoichiometry: 1.0
species: 868361

916825
type: SpeciesReference
stoichiometry: 1.0
species: 866088

916849
type: SpeciesReference
stoichiometry: 1.0
species: 866283

916837
type: SpeciesReference
stoichiometry: 1.0
species: 865568

916921
type: LocalParameter
value: 0.0

916909
type: LocalParameter
value: 0.0

916897
type: LocalParameter
value: 1000.0

916885
type: LocalParameter
value: -1000.0

916801
type: SpeciesReference
stoichiometry: 1.0
species: 865641

940369
type: Reaction
name: isocitrate dehydrogenase (NADP)
reactant: 940381
product: 940417
reversible: true
reactant: 940393
fast: false
product: 940405
notes: GENE_ASSOCIATION: NM_005896.2 GENE_LIST: NM_005896.2 SUBSYSTEM: Citrate Cycle (TCA)
product: 940429
kinetic law: 940441

940381
type: SpeciesReference
stoichiometry: 1.0
species: 867444

867444
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Isocitrate

940417
type: SpeciesReference
stoichiometry: 1.0
species: 865871

940393
type: SpeciesReference
stoichiometry: 1.0
species: 867818

940405
type: SpeciesReference
stoichiometry: 1.0
species: 865520

940429
type: SpeciesReference
stoichiometry: 1.0
species: 867830

940489
type: LocalParameter
value: 0.0

940477
type: LocalParameter
value: 0.0

940465
type: LocalParameter
value: 1000.0

940453
type: LocalParameter
value: -1000.0

914893
type: Reaction
fast: false
reactant: 914917
name: fatty-acid--CoA ligase (octadecadienoate, C18:3 n-6)
reversible: true
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
kinetic law: 914978
reactant: 914929
reactant: 914905
product: 914941
product: 914953
product: 914966

914917
type: SpeciesReference
stoichiometry: 1.0
species: 865883

915028
type: LocalParameter
value: 0.0

915015
type: LocalParameter
value: 0.0

915002
type: LocalParameter
value: 1000.0

914990
type: LocalParameter
value: -1000.0

914929
type: SpeciesReference
stoichiometry: 1.0
species: 867928

914905
type: SpeciesReference
stoichiometry: 1.0
species: 865641

914941
type: SpeciesReference
stoichiometry: 1.0
species: 865568

914953
type: SpeciesReference
stoichiometry: 1.0
species: 868012

914966
type: SpeciesReference
stoichiometry: 1.0
species: 868361

964652
type: Reaction
fast: false
reversible: false
name: superoxide dismutase, mitochondrial
product: 964700
reactant: 964664
product: 964688
notes: GENE_ASSOCIATION: (NM_001024466.1 or NM_000636.2 or NM_001024465.1) GENE_LIST: NM_000636.2 NM_001024465.1 NM_001024466.1 SUBSYSTEM: ROS Detoxification
reactant: 964676
kinetic law: 964712

964700
type: SpeciesReference
stoichiometry: 1.0
species: 870526

964664
type: SpeciesReference
stoichiometry: 2.0
species: 870140

964688
type: SpeciesReference
stoichiometry: 1.0
species: 870164

964676
type: SpeciesReference
stoichiometry: 2.0
species: 870539

870539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Superoxide

964760
type: LocalParameter
value: 500.0

964748
type: LocalParameter
value: 0.0

964736
type: LocalParameter
value: 1000.0

964724
type: LocalParameter
value: 0.0

869547
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Carbamoyl phosphate

953548
type: Reaction
reactant: 953572
reactant: 953560
reactant: 953584
kinetic law: 953632
reversible: false
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
notes: SUBSYSTEM: Bile Acid Biosynthesis
product: 953608
fast: false
product: 953596
product: 953620

953572
type: SpeciesReference
stoichiometry: 1.0
species: 870526

953560
type: SpeciesReference
stoichiometry: 1.0
species: 870461

953584
type: SpeciesReference
stoichiometry: 1.0
species: 871070

953680
type: LocalParameter
value: 500.0

953668
type: LocalParameter
value: 0.0

953656
type: LocalParameter
value: 1000.0

953644
type: LocalParameter
value: 0.0

953608
type: SpeciesReference
stoichiometry: 1.0
species: 870448

953596
type: SpeciesReference
stoichiometry: 1.0
species: 870152

953620
type: SpeciesReference
stoichiometry: 1.0
species: 871082

865074
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Methyl-2-oxobutanoate

968653
type: Reaction
reactant: 968665
product: 968701
reversible: false
name: triglycerol synthesis, hepatocyte
reactant: 968677
kinetic law: 968713
fast: false
notes: GENE_ASSOCIATION: (NM_012079.3 or NM_032564.2 or NM_178176.2) GENE_LIST: NM_012079.3 NM_032564.2 NM_178176.2 SUBSYSTEM: Triacylglycerol Synthesis
product: 968689

968665
type: SpeciesReference
stoichiometry: 0.001
species: 864893

968701
type: SpeciesReference
stoichiometry: 0.001
species: 868818

968677
type: SpeciesReference
stoichiometry: 0.001
species: 866780

968761
type: LocalParameter
value: 500.0

968749
type: LocalParameter
value: 0.0

968737
type: LocalParameter
value: 1000.0

968725
type: LocalParameter
value: 0.0

968689
type: SpeciesReference
stoichiometry: 1.0
species: 865883

921409
type: Reaction
name: Beta oxidation of fatty acid
product: 921493
reactant: 921457
reactant: 921445
reversible: false
reactant: 921469
product: 921505
fast: false
product: 921517
reactant: 921433
kinetic law: 921529
product: 921481
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and N... GENE_LIST: N... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 921421

921493
type: SpeciesReference
stoichiometry: 8.0
species: 869957

921457
type: SpeciesReference
stoichiometry: 9.0
species: 870152

921445
type: SpeciesReference
stoichiometry: 8.0
species: 869945

921469
type: SpeciesReference
stoichiometry: 9.0
species: 870448

921505
type: SpeciesReference
stoichiometry: 9.0
species: 870140

921517
type: SpeciesReference
stoichiometry: 9.0
species: 870461

921433
type: SpeciesReference
stoichiometry: 1.0
species: 869824

921577
type: LocalParameter
value: 500.0

921565
type: LocalParameter
value: 0.0

921553
type: LocalParameter
value: 1000.0

921541
type: LocalParameter
value: 0.0

921481
type: SpeciesReference
stoichiometry: 10.0
species: 869412

921421
type: SpeciesReference
stoichiometry: 9.0
species: 869643

942063
type: Reaction
reactant: 942075
product: 942099
kinetic law: 942123
product: 942111
fast: false
name: L-lactate reversible transport via proton symport
notes: GENE_ASSOCIATION: (NM_001042422.1 or NM_004696.1 or NM_001042423.1 or NM_003051.3 or NM_004207.1 or NM_004694.2 or NM_004731.3 or NM_013356.1 or NM_004695.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular
reactant: 942087
reversible: true

942075
type: SpeciesReference
stoichiometry: 1.0
species: 864405

942099
type: SpeciesReference
stoichiometry: 1.0
species: 867216

942171
type: LocalParameter
value: 0.0

942159
type: LocalParameter
value: 0.0

942147
type: LocalParameter
value: 1000.0

942135
type: LocalParameter
value: -1000.0

942111
type: SpeciesReference
stoichiometry: 1.0
species: 867577

942087
type: SpeciesReference
stoichiometry: 1.0
species: 864515

870383
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 5,10-Methylenetetrahydrofolate

967444
type: Reaction
kinetic law: 967493
product: 967481
product: 967469
reactant: 967457
notes: SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false
reversible: true
name: threonine aldolase

967541
type: LocalParameter
value: 0.0

967529
type: LocalParameter
value: 0.0

967517
type: LocalParameter
value: 1000.0

967505
type: LocalParameter
value: -1000.0

967481
type: SpeciesReference
stoichiometry: 1.0
species: 867095

967469
type: SpeciesReference
stoichiometry: 1.0
species: 865400

967457
type: SpeciesReference
stoichiometry: 1.0
species: 868770

869109
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-2-Amino-3-oxobutanoate

871917
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Superoxide

954572
type: Reaction
kinetic law: 954609
product: 954596
reactant: 954584
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: phosphatidate reversible transport, mitochondrial, hepatocyte

954658
type: LocalParameter
value: 0.0

954645
type: LocalParameter
value: 0.0

954633
type: LocalParameter
value: 1000.0

954621
type: LocalParameter
value: -1000.0

954596
type: SpeciesReference
stoichiometry: 1.0
species: 870707

870707
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Phosphatidate, Hepatocyte

954584
type: SpeciesReference
stoichiometry: 1.0
species: 868133

944047
type: Reaction
reactant: 944071
reversible: true
product: 944095
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
product: 944083
kinetic law: 944108
fast: false
name: Malate:sulfite antiport, mitochondrial
reactant: 944059

944071
type: SpeciesReference
stoichiometry: 1.0
species: 870935

944095
type: SpeciesReference
stoichiometry: 1.0
species: 870359

944083
type: SpeciesReference
stoichiometry: 1.0
species: 868565

944156
type: LocalParameter
value: 0.0

944144
type: LocalParameter
value: 0.0

944132
type: LocalParameter
value: 1000.0

944120
type: LocalParameter
value: -1000.0

944059
type: SpeciesReference
stoichiometry: 1.0
species: 867626

870671
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Ornithine

874266
type: Reaction
kinetic law: 874302
product: 874290
reactant: 874278
fast: false
reversible: true
name: Cholesterol ester, hepatocyte exchange

874350
type: LocalParameter
value: 500.0

874338
type: LocalParameter
value: 0.0

874326
type: LocalParameter
value: 1000.0

874314
type: LocalParameter
value: 0.0

874290
type: SpeciesReference
stoichiometry: 1.0
species: 872110

874278
type: SpeciesReference
stoichiometry: 1.0
species: 864126

864126
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Cholesterol ester, hepatocyte

957628
type: Reaction
reactant: 957652
kinetic law: 957688
product: 957664
name: phosphate transporter, mitochondrial
reversible: true
fast: false
reactant: 957640
notes: GENE_ASSOCIATION: (NM_213611.1 or NM_005888.2 or NM_002635.2) GENE_LIST: NM_002635.2 NM_005888.2 NM_213611.1 SUBSYSTEM: Transport, Mitochondrial
product: 957676

957652
type: SpeciesReference
stoichiometry: 1.0
species: 868265

957736
type: LocalParameter
value: 0.0

957724
type: LocalParameter
value: 0.0

957712
type: LocalParameter
value: 1000.0

957700
type: LocalParameter
value: -1000.0

957664
type: SpeciesReference
stoichiometry: 1.0
species: 870140

957640
type: SpeciesReference
stoichiometry: 1.0
species: 867216

957676
type: SpeciesReference
stoichiometry: 1.0
species: 870803

903369
type: Reaction
product: 903417
name: carnitine palmitoyltransferase (C16:0Crn), mitochondrial
reactant: 903393
kinetic law: 903429
reversible: true
reactant: 903381
product: 903405
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle

903417
type: SpeciesReference
stoichiometry: 1.0
species: 870815

870815
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Palmitoyl-CoA (n-C16:0CoA)

903393
type: SpeciesReference
stoichiometry: 1.0
species: 870827

903477
type: LocalParameter
value: 0.0

903465
type: LocalParameter
value: 0.0

903453
type: LocalParameter
value: 1000.0

903441
type: LocalParameter
value: -1000.0

903381
type: SpeciesReference
stoichiometry: 1.0
species: 869643

903405
type: SpeciesReference
stoichiometry: 1.0
species: 869655

890218
type: Reaction
reactant: 890242
product: 890267
name: aspartate transaminase, mitochondrial
fast: false
notes: GENE_ASSOCIATION: NM_002080.2 GENE_LIST: NM_002080.2 SUBSYSTEM: Cysteine Metabolism
reactant: 890230
kinetic law: 890280
product: 890254
reversible: false

890242
type: SpeciesReference
stoichiometry: 1.0
species: 869448

890267
type: SpeciesReference
stoichiometry: 1.0
species: 870948

870948
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: 3-Sulfinylpyruvate

890230
type: SpeciesReference
stoichiometry: 1.0
species: 869303

890328
type: LocalParameter
value: 500.0

890316
type: LocalParameter
value: 0.0

890304
type: LocalParameter
value: 1000.0

890292
type: LocalParameter
value: 0.0

890254
type: SpeciesReference
stoichiometry: 1.0
species: 870055

868385
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Protoporphyrinogen IX

946289
type: Reaction
notes: GENE_ASSOCIATION: (NM_005536.2 or NM_014214.1) GENE_LIST: NM_005536.2 NM_014214.1 SUBSYSTEM: Inositol Phosphate Metabolism
fast: false
reversible: false
product: 946337
reactant: 946313
name: myo-inositol 1-phosphatase
reactant: 946301
product: 946325
kinetic law: 946349

946337
type: SpeciesReference
stoichiometry: 1.0
species: 868265

946313
type: SpeciesReference
stoichiometry: 1.0
species: 867722

946301
type: SpeciesReference
stoichiometry: 1.0
species: 867228

946325
type: SpeciesReference
stoichiometry: 1.0
species: 867516

946397
type: LocalParameter
value: 500.0

946385
type: LocalParameter
value: 0.0

946373
type: LocalParameter
value: 1000.0

946361
type: LocalParameter
value: 0.0

946796
type: Reaction
kinetic law: 946832
product: 946820
reactant: 946808
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: Methylmalonate transport, mitochondrial

946881
type: LocalParameter
value: 0.0

946869
type: LocalParameter
value: 0.0

946857
type: LocalParameter
value: 1000.0

946845
type: LocalParameter
value: -1000.0

946820
type: SpeciesReference
stoichiometry: 1.0
species: 867746

867746
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Methylmalonate

946808
type: SpeciesReference
stoichiometry: 1.0
species: 870395

878731
type: Reaction
kinetic law: 878767
product: 878755
reactant: 878743
fast: false
reversible: true
name: Ornithine exchange

878815
type: LocalParameter
value: 500.0

878803
type: LocalParameter
value: 0.0

878791
type: LocalParameter
value: 1000.0

878779
type: LocalParameter
value: 0.0

878755
type: SpeciesReference
stoichiometry: 1.0
species: 872667

878743
type: SpeciesReference
stoichiometry: 1.0
species: 864687

903850
type: Reaction
reactant: 903874
reversible: true
reactant: 903862
kinetic law: 903910
product: 903898
fast: false
name: tetradecenoyl carnitine transport (C14:1Crn, n7)
product: 903886
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

903874
type: SpeciesReference
stoichiometry: 1.0
species: 869655

903862
type: SpeciesReference
stoichiometry: 1.0
species: 868722

903958
type: LocalParameter
value: 0.0

903946
type: LocalParameter
value: 0.0

903934
type: LocalParameter
value: 1000.0

903922
type: LocalParameter
value: -1000.0

903898
type: SpeciesReference
stoichiometry: 1.0
species: 871058

903886
type: SpeciesReference
stoichiometry: 1.0
species: 865907

949523
type: Reaction
reactant: 949547
name: nucleoside-diphosphate kinase (ATP:dGDP)
reactant: 949535
product: 949559
notes: GENE_ASSOCIATION: ((NM_001018138.1 and NM_198175.1) or (NM_002512.2 and NM_198175.1) or NM_005793.3 or NM_002513.2 or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_197972.1 or NM_013330.3 or (NM_000269.2 and NM_001018139.1) or (NM_000269.2 and NM_001018138.1) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_002512.2)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotides
product: 949571
reversible: true
kinetic law: 949583
fast: false

949547
type: SpeciesReference
stoichiometry: 1.0
species: 866185

949535
type: SpeciesReference
stoichiometry: 1.0
species: 865641

949559
type: SpeciesReference
stoichiometry: 1.0
species: 865460

949571
type: SpeciesReference
stoichiometry: 1.0
species: 866197

949631
type: LocalParameter
value: 0.0

949619
type: LocalParameter
value: 0.0

949607
type: LocalParameter
value: 1000.0

949595
type: LocalParameter
value: -1000.0

936413
type: Reaction
reactant: 936425
reversible: true
reactant: 936437
name: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) mitochondrial
notes: GENE_ASSOCIATION: (NM_004493.2 or NM_001037811.2 or NM_005327.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000182.3 NM_000183.1 NM_001037811.2 NM_004493.2 NM_005327.2 SUBSYSTEM: Tryptophan metabolism
kinetic law: 936485
product: 936461
product: 936473
reactant: 936449
fast: false

936425
type: SpeciesReference
stoichiometry: 1.0
species: 869364

936437
type: SpeciesReference
stoichiometry: 1.0
species: 870140

936533
type: LocalParameter
value: 0.0

936521
type: LocalParameter
value: 0.0

936509
type: LocalParameter
value: 1000.0

936497
type: LocalParameter
value: -1000.0

936461
type: SpeciesReference
stoichiometry: 1.0
species: 869218

869218
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-3-Hydroxybutyryl-CoA

936473
type: SpeciesReference
stoichiometry: 1.0
species: 870448

936449
type: SpeciesReference
stoichiometry: 1.0
species: 870461

891615
type: Reaction
kinetic law: 891693
reactant: 891628
notes: GENE_ASSOCIATION: (NM_203314.2 or NM_203315.2 or NM_004051.4) GENE_LIST: NM_004051.4 NM_203314.2 NM_203315.2 SUBSYSTEM: Ketone Body Synthesis
reversible: true
fast: false
product: 891667
product: 891680
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
product: 891654
reactant: 891641

891742
type: LocalParameter
value: 0.0

891730
type: LocalParameter
value: 0.0

891718
type: LocalParameter
value: 1000.0

891706
type: LocalParameter
value: -1000.0

891628
type: SpeciesReference
stoichiometry: 1.0
species: 869206

869206
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (R)-3-Hydroxybutanoate

891667
type: SpeciesReference
stoichiometry: 1.0
species: 870140

891680
type: SpeciesReference
stoichiometry: 1.0
species: 870461

891654
type: SpeciesReference
stoichiometry: 1.0
species: 869400

891641
type: SpeciesReference
stoichiometry: 1.0
species: 870448

941070
type: Reaction
kinetic law: 941118
product: 941106
reactant: 941094
reactant: 941082
notes: GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
fast: false
reversible: true
name: IMP cyclohydrolase

941166
type: LocalParameter
value: 0.0

941154
type: LocalParameter
value: 0.0

941142
type: LocalParameter
value: 1000.0

941130
type: LocalParameter
value: -1000.0

941106
type: SpeciesReference
stoichiometry: 1.0
species: 866888

941094
type: SpeciesReference
stoichiometry: 1.0
species: 867504

941082
type: SpeciesReference
stoichiometry: 1.0
species: 867228

939251
type: Reaction
kinetic law: 939299
product: 939287
product: 939275
reactant: 939263
notes: GENE_ASSOCIATION: (NM_001042406.1 or NM_000191.2 or NM_019036.1) GENE_LIST: NM_000191.2 NM_001042406.1 NM_019036.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: false
name: hydroxymethylglutaryl-CoA lyase, mitochondrial

939349
type: LocalParameter
value: 500.0

939336
type: LocalParameter
value: 0.0

939323
type: LocalParameter
value: 1000.0

939311
type: LocalParameter
value: 0.0

939287
type: SpeciesReference
stoichiometry: 1.0
species: 869412

939275
type: SpeciesReference
stoichiometry: 1.0
species: 869400

939263
type: SpeciesReference
stoichiometry: 1.0
species: 870225

870225
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Hydroxymethylglutaryl-CoA

971417
type: Reaction
kinetic law: 971453
product: 971441
reactant: 971429
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Valine transport, Homo Sapiens passive diffusion

971501
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value: 0.0

971489
type: LocalParameter
value: 0.0

971477
type: LocalParameter
value: 1000.0

971465
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value: -1000.0

971441
type: SpeciesReference
stoichiometry: 1.0
species: 871142

871142
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Valine

971429
type: SpeciesReference
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species: 869000

959824
type: Reaction
kinetic law: 959861
product: 959849
reactant: 959837
notes: GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: protoporphyrin transport, mitochondrial

959909
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value: 0.0

959897
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value: 0.0

959885
type: LocalParameter
value: 1000.0

959873
type: LocalParameter
value: -1000.0

959849
type: SpeciesReference
stoichiometry: 1.0
species: 868373

868373
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Protoporphyrin

959837
type: SpeciesReference
stoichiometry: 1.0
species: 870875

870875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Protoporphyrin

887859
type: Reaction
product: 887920
product: 887908
name: aldehyde dehydrogenase (NAD), mitochondrial
product: 887932
reversible: false
kinetic law: 887944
fast: false
reactant: 887871
reactant: 887884
notes: GENE_ASSOCIATION: (NM_000690.2 or NM_000692.3) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 887896

887920
type: SpeciesReference
stoichiometry: 1.0
species: 870395

887908
type: SpeciesReference
stoichiometry: 2.0
species: 870140

887932
type: SpeciesReference
stoichiometry: 1.0
species: 870461

887992
type: LocalParameter
value: 500.0

887980
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value: 0.0

887968
type: LocalParameter
value: 1000.0

887956
type: LocalParameter
value: 0.0

887871
type: SpeciesReference
stoichiometry: 1.0
species: 870152

887884
type: SpeciesReference
stoichiometry: 1.0
species: 870408

870408
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: (S)-Methylmalonate semialdehyde

887896
type: SpeciesReference
stoichiometry: 1.0
species: 870448

945025
type: Reaction
reactant: 945049
kinetic law: 945097
product: 945061
reactant: 945037
fast: false
name: malic enzyme (NAD), mitochondrial
product: 945085
reversible: false
notes: GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Pyruvate Metabolism
product: 945073

945049
type: SpeciesReference
stoichiometry: 1.0
species: 870448

945146
type: LocalParameter
value: 500.0

945134
type: LocalParameter
value: 0.0

945122
type: LocalParameter
value: 1000.0

945110
type: LocalParameter
value: 0.0

945061
type: SpeciesReference
stoichiometry: 1.0
species: 869631

945037
type: SpeciesReference
stoichiometry: 1.0
species: 870359

945085
type: SpeciesReference
stoichiometry: 1.0
species: 870911

945073
type: SpeciesReference
stoichiometry: 1.0
species: 870461

889299
type: Reaction
name: L-asparaginase
product: 889347
notes: GENE_ASSOCIATION: (NM_025080.2 or NM_001083926.1) GENE_LIST: NM_001083926.1 NM_025080.2 SUBSYSTEM: Asparagine Metabolism
product: 889335
fast: false
reactant: 889323
kinetic law: 889359
reactant: 889311
reversible: false

889347
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stoichiometry: 1.0
species: 867842

889335
type: SpeciesReference
stoichiometry: 1.0
species: 865629

889323
type: SpeciesReference
stoichiometry: 1.0
species: 867228

889407
type: LocalParameter
value: 500.0

889395
type: LocalParameter
value: 0.0

889383
type: LocalParameter
value: 1000.0

889371
type: LocalParameter
value: 0.0

889311
type: SpeciesReference
stoichiometry: 1.0
species: 865617

967204
type: Reaction
fast: false
product: 967252
product: 967264
name: NAD(P) transhydrogenase
product: 967276
reactant: 967240
reversible: false
notes: GENE_ASSOCIATION: (NM_012343.2 or NM_182977.1) GENE_LIST: NM_012343.2 NM_182977.1 SUBSYSTEM: NAD Metabolism
reactant: 967216
kinetic law: 967288
reactant: 967228

967252
type: SpeciesReference
stoichiometry: 1.0
species: 870140

967264
type: SpeciesReference
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species: 870448

967276
type: SpeciesReference
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species: 870487

967240
type: SpeciesReference
stoichiometry: 1.0
species: 870474

967216
type: SpeciesReference
stoichiometry: 1.0
species: 867216

967336
type: LocalParameter
value: 500.0

967324
type: LocalParameter
value: 0.0

967312
type: LocalParameter
value: 1000.0

967300
type: LocalParameter
value: 0.0

967228
type: SpeciesReference
stoichiometry: 1.0
species: 870461

864260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosatrienoate (C20:3,n-9)

923422
type: Reaction
product: 923495
name: Beta oxidation of fatty acid
reactant: 923470
reactant: 923483
reversible: false
product: 923519
fast: false
reactant: 923446
product: 923507
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_000017.2 and (NM_000182.3 and NM_000183.1)) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004... GENE_LIST: NM_000016.2 NM_000017.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
product: 923544
reactant: 923434
kinetic law: 923557
product: 923531
reactant: 923458

923495
type: SpeciesReference
stoichiometry: 1.0
species: 869412

923470
type: SpeciesReference
stoichiometry: 1.0
species: 870275

923483
type: SpeciesReference
stoichiometry: 1.0
species: 870448

923519
type: SpeciesReference
stoichiometry: 1.0
species: 869957

923446
type: SpeciesReference
stoichiometry: 1.0
species: 869945

923507
type: SpeciesReference
stoichiometry: 1.0
species: 869535

923544
type: SpeciesReference
stoichiometry: 1.0
species: 870461

923434
type: SpeciesReference
stoichiometry: 1.0
species: 869643

923605
type: LocalParameter
value: 500.0

923593
type: LocalParameter
value: 0.0

923581
type: LocalParameter
value: 1000.0

923569
type: LocalParameter
value: 0.0

923531
type: SpeciesReference
stoichiometry: 1.0
species: 870140

923458
type: SpeciesReference
stoichiometry: 1.0
species: 870152

927052
type: Reaction
kinetic law: 927088
product: 927076
reactant: 927064
notes: GENE_ASSOCIATION: (NM_031212.2 or NM_016612.2) GENE_LIST: NM_016612.2 NM_031212.2 SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: iron (II) transport

927137
type: LocalParameter
value: 0.0

927125
type: LocalParameter
value: 0.0

927113
type: LocalParameter
value: 1000.0

927101
type: LocalParameter
value: -1000.0

927076
type: SpeciesReference
stoichiometry: 1.0
species: 869969

927064
type: SpeciesReference
stoichiometry: 1.0
species: 866816

866816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Fe2+

902163
type: Reaction
product: 902212
name: ocosatetraenoyl carnitine transport (C22:4Crn, n6)
reactant: 902187
product: 902199
reactant: 902175
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 902224
fast: false
reversible: true

902212
type: SpeciesReference
stoichiometry: 1.0
species: 870695

870695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: ocosatetraenoyl carnitine (C22:4Crn, n-6)

902187
type: SpeciesReference
stoichiometry: 1.0
species: 869655

902199
type: SpeciesReference
stoichiometry: 1.0
species: 865907

902175
type: SpeciesReference
stoichiometry: 1.0
species: 868121

902272
type: LocalParameter
value: 0.0

902260
type: LocalParameter
value: 0.0

902248
type: LocalParameter
value: 1000.0

902236
type: LocalParameter
value: -1000.0

870635
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecatrienoyl carnitine (C18:3Crn, n6)

926352
type: Reaction
kinetic law: 926400
product: 926388
product: 926376
reactant: 926364
notes: GENE_ASSOCIATION: (NM_184041.1 or NM_005165.2 or NM_184043.1 or NM_000034.2 or NM_000035.2) GENE_LIST: NM_000034.2 NM_000035.2 NM_005165.2 NM_184041.1 NM_184043.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: fructose-bisphosphate aldolase

926448
type: LocalParameter
value: 0.0

926436
type: LocalParameter
value: 0.0

926424
type: LocalParameter
value: 1000.0

926412
type: LocalParameter
value: -1000.0

926388
type: SpeciesReference
stoichiometry: 1.0
species: 866950

926376
type: SpeciesReference
stoichiometry: 1.0
species: 866209

926364
type: SpeciesReference
stoichiometry: 1.0
species: 866804

866804
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Fructose 1,6-bisphosphate

939469
type: Reaction
kinetic law: 939506
product: 939494
reactant: 939481
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion, blood

939555
type: LocalParameter
value: 0.0

939543
type: LocalParameter
value: 0.0

939531
type: LocalParameter
value: 1000.0

939519
type: LocalParameter
value: -1000.0

939494
type: SpeciesReference
stoichiometry: 1.0
species: 867396

939481
type: SpeciesReference
stoichiometry: 1.0
species: 864479

936124
type: Reaction
kinetic law: 936161
product: 936149
reactant: 936137
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: H2O endoplasmic reticulum transport

936209
type: LocalParameter
value: 0.0

936197
type: LocalParameter
value: 0.0

936185
type: LocalParameter
value: 1000.0

936173
type: LocalParameter
value: -1000.0

936149
type: SpeciesReference
stoichiometry: 1.0
species: 871397

936137
type: SpeciesReference
stoichiometry: 1.0
species: 867228

948018
type: Reaction
product: 948054
kinetic law: 948078
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial
fast: false
notes: GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3 SUBSYSTEM: Folate Metabolism
reactant: 948030
product: 948066
reversible: true
reactant: 948042

948054
type: SpeciesReference
stoichiometry: 1.0
species: 870371

948128
type: LocalParameter
value: 0.0

948115
type: LocalParameter
value: 0.0

948102
type: LocalParameter
value: 1000.0

948090
type: LocalParameter
value: -1000.0

948030
type: SpeciesReference
stoichiometry: 1.0
species: 870383

948066
type: SpeciesReference
stoichiometry: 1.0
species: 870461

948042
type: SpeciesReference
stoichiometry: 1.0
species: 870448

892598
type: Reaction
product: 892659
reversible: false
product: 892683
notes: GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 892622
reactant: 892634
kinetic law: 892695
name: C-4 methyl sterol oxidase NADPH
product: 892671
reactant: 892610
product: 892647
fast: false

892659
type: SpeciesReference
stoichiometry: 1.0
species: 871385

892683
type: SpeciesReference
stoichiometry: 1.0
species: 871566

892622
type: SpeciesReference
stoichiometry: 1.0
species: 871457

892634
type: SpeciesReference
stoichiometry: 1.0
species: 871481

892743
type: LocalParameter
value: 500.0

892731
type: LocalParameter
value: 0.0

892719
type: LocalParameter
value: 1000.0

892707
type: LocalParameter
value: 0.0

892671
type: SpeciesReference
stoichiometry: 1.0
species: 871469

892610
type: SpeciesReference
stoichiometry: 1.0
species: 871215

892647
type: SpeciesReference
stoichiometry: 1.0
species: 871300

912561
type: Reaction
kinetic law: 912598
product: 912586
reactant: 912574
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatrienoate (C20:3, n-6) transport

912647
type: LocalParameter
value: 0.0

912635
type: LocalParameter
value: 0.0

912623
type: LocalParameter
value: 1000.0

912610
type: LocalParameter
value: -1000.0

912586
type: SpeciesReference
stoichiometry: 1.0
species: 866524

912574
type: SpeciesReference
stoichiometry: 1.0
species: 864248

874845
type: Reaction
kinetic law: 874881
product: 874869
reactant: 874857
fast: false
reversible: true
name: dodecanoate (C12:0) exchange

874929
type: LocalParameter
value: 500.0

874917
type: LocalParameter
value: 0.0

874905
type: LocalParameter
value: 1000.0

874893
type: LocalParameter
value: 0.0

874869
type: SpeciesReference
stoichiometry: 1.0
species: 872182

874857
type: SpeciesReference
stoichiometry: 1.0
species: 864200

937272
type: Reaction
reversible: true
reactant: 937296
product: 937308
fast: false
kinetic law: 937332
reactant: 937284
name: bicarbonate transport (Na/HCO3 cotransport), blood
product: 937320
notes: GENE_ASSOCIATION: (NM_021196.2 or NM_133478.1 or NM_003615.2 or NM_003759.1 or NM_001098484.1) GENE_LIST: NM_001098484.1 NM_003615.2 NM_003759.1 NM_021196.2 NM_133478.1 SUBSYSTEM: Transport, Extracellular

937296
type: SpeciesReference
stoichiometry: 1.0
species: 864576

937308
type: SpeciesReference
stoichiometry: 1.0
species: 867252

937380
type: LocalParameter
value: 0.0

937368
type: LocalParameter
value: 0.0

937356
type: LocalParameter
value: 1000.0

937344
type: LocalParameter
value: -1000.0

937284
type: SpeciesReference
stoichiometry: 1.0
species: 864430

937320
type: SpeciesReference
stoichiometry: 1.0
species: 867782

872291
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: fe2_b

898313
type: Reaction
product: 898349
product: 898361
reactant: 898325
fast: false
kinetic law: 898373
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
name: carnitine eicosatetraenoyltransferase (C20:4Crn, n6)
reactant: 898337

898349
type: SpeciesReference
stoichiometry: 1.0
species: 865883

898361
type: SpeciesReference
stoichiometry: 1.0
species: 866720

866720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)

898325
type: SpeciesReference
stoichiometry: 1.0
species: 865907

898421
type: LocalParameter
value: 0.0

898409
type: LocalParameter
value: 0.0

898397
type: LocalParameter
value: 1000.0

898385
type: LocalParameter
value: -1000.0

898337
type: SpeciesReference
stoichiometry: 1.0
species: 866707

867432
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Hexanoate

896125
type: Reaction
reversible: true
kinetic law: 896185
reactant: 896149
fast: false
name: carnitine dodecanoyltransferase (C12:0Crn)
product: 896161
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 896173
reactant: 896137

896233
type: LocalParameter
value: 0.0

896221
type: LocalParameter
value: 0.0

896209
type: LocalParameter
value: 1000.0

896197
type: LocalParameter
value: -1000.0

896149
type: SpeciesReference
stoichiometry: 1.0
species: 866161

896161
type: SpeciesReference
stoichiometry: 1.0
species: 865883

896173
type: SpeciesReference
stoichiometry: 1.0
species: 866173

866173
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dodecanoylcarnitine (C12:0Crn)

896137
type: SpeciesReference
stoichiometry: 1.0
species: 865907

866356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: dTDP

939117
type: Reaction
product: 939178
fast: false
reversible: true
product: 939166
kinetic law: 939190
notes: GENE_ASSOCIATION: NM_000671.3 GENE_LIST: NM_000671.3 SUBSYSTEM: Tyrosine metabolism
reactant: 939141
name: S-(hydroxymethyl)glutathione dehydrogenase
product: 939154
reactant: 939129

939178
type: SpeciesReference
stoichiometry: 1.0
species: 867806

939166
type: SpeciesReference
stoichiometry: 1.0
species: 867216

939239
type: LocalParameter
value: 0.0

939226
type: LocalParameter
value: 0.0

939214
type: LocalParameter
value: 1000.0

939202
type: LocalParameter
value: -1000.0

939141
type: SpeciesReference
stoichiometry: 1.0
species: 867794

939154
type: SpeciesReference
stoichiometry: 1.0
species: 866840

939129
type: SpeciesReference
stoichiometry: 1.0
species: 867384

945832
type: Reaction
reactant: 945844
fast: false
reactant: 945856
reversible: true
name: L-methionine transport in via sodium symport, blood
notes: GENE_ASSOCIATION: (NM_001077484.1 or NM_030674.2 or NM_018018.2 or NM_007231.1 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
kinetic law: 945892
product: 945868
product: 945880

945844
type: SpeciesReference
stoichiometry: 1.0
species: 864564

945856
type: SpeciesReference
stoichiometry: 1.0
species: 864576

945940
type: LocalParameter
value: 0.0

945928
type: LocalParameter
value: 0.0

945916
type: LocalParameter
value: 1000.0

945904
type: LocalParameter
value: -1000.0

945868
type: SpeciesReference
stoichiometry: 1.0
species: 867686

945880
type: SpeciesReference
stoichiometry: 1.0
species: 867782

896971
type: Reaction
reactant: 896983
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reactant: 896995
name: docosapentaenoyl carnitine transport (C22:5Crn, n3)
fast: false
kinetic law: 897031
product: 897019
product: 897007

896983
type: SpeciesReference
stoichiometry: 1.0
species: 866332

866332
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: docosapentaenoyl carnitine (C22:5Crn, n-3)

896995
type: SpeciesReference
stoichiometry: 1.0
species: 869655

897080
type: LocalParameter
value: 0.0

897068
type: LocalParameter
value: 0.0

897055
type: LocalParameter
value: 1000.0

897043
type: LocalParameter
value: -1000.0

897019
type: SpeciesReference
stoichiometry: 1.0
species: 869763

897007
type: SpeciesReference
stoichiometry: 1.0
species: 865907

865266
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Methylthioadenosine

868517
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: D-Ribulose 5-phosphate

918586
type: Reaction
reactant: 918634
reversible: false
reactant: 918622
reactant: 918610
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
kinetic law: 918721
product: 918696
product: 918671
product: 918709
product: 918683
product: 918658
fast: false
reactant: 918598
name: Beta oxidation of odd chain fatty acid
reactant: 918646

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species: 870152

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species: 869945

918610
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stoichiometry: 1.0
species: 869812

869812
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: endecanoyl-CoA (C11:0CoA)

918769
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value: 500.0

918757
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value: 0.0

918745
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value: 1000.0

918733
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value: 0.0

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species: 870461

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species: 869957

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species: 870513

918683
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species: 870140

918658
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stoichiometry: 1.0
species: 869412

918598
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stoichiometry: 1.0
species: 869643

918646
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stoichiometry: 1.0
species: 870448

898553
type: Reaction
product: 898589
reversible: true
fast: false
name: eicosatetraenoyl carnitine transport (C20:4Crn, n6)
reactant: 898565
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 898601
reactant: 898577
kinetic law: 898613

898589
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species: 865907

898565
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stoichiometry: 1.0
species: 866720

898601
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species: 869933

898577
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stoichiometry: 1.0
species: 869655

898661
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value: 0.0

898649
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value: 0.0

898637
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value: 1000.0

898625
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value: -1000.0

929764
type: Reaction
notes: GENE_ASSOCIATION: (NM_000402.2 or NM_001042351.1) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 929776
fast: false
product: 929825
product: 929813
reactant: 929789
name: glucose 6-phosphate dehydrogenase
kinetic law: 929837
reversible: true
product: 929801

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stoichiometry: 1.0
species: 866962

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stoichiometry: 1.0
species: 867830

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species: 867216

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species: 867818

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value: 0.0

929873
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value: 0.0

929861
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value: 1000.0

929849
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value: -1000.0

929801
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stoichiometry: 1.0
species: 865303

869049
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane

880187
type: Reaction
kinetic law: 880223
product: 880211
reactant: 880199
fast: false
reversible: true
name: L-Valine exchange

880271
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value: -0.006331015

880259
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value: 0.0

880247
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value: 0.0

880235
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value: -0.01266203

880211
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stoichiometry: 1.0
species: 872852

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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: val_L_b

880199
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stoichiometry: 1.0
species: 864869

946699
type: Reaction
kinetic law: 946736
product: 946724
reactant: 946711
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde transport, mitochondrial

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946772
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value: 0.0

946760
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value: 1000.0

946748
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946724
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stoichiometry: 1.0
species: 867758

946711
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stoichiometry: 1.0
species: 870408

868952
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Urocanate

906610
type: Reaction
product: 906646
fast: false
name: cytidylate kinase (CMP)(GTP)
reactant: 906622
product: 906658
reactant: 906634
reversible: true
notes: SUBSYSTEM: Nucleotide Metabolism
kinetic law: 906670

906646
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species: 865701

906622
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species: 865859

906658
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species: 867023

906634
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species: 867204

906718
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906706
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value: 0.0

906694
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value: 1000.0

906682
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value: -1000.0

901202
type: Reaction
kinetic law: 901262
fast: false
reactant: 901226
name: carnitine octadecatrienoyltransferase (C18:3Crn, n3)
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_001876.2 or NM_152245.1 or NM_152359.1 or NM_004377.2 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 901214
reversible: true
product: 901250
product: 901238

901310
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value: 0.0

901298
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value: 0.0

901286
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value: 1000.0

901274
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value: -1000.0

901226
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stoichiometry: 1.0
species: 868000

901214
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species: 865907

901250
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stoichiometry: 1.0
species: 868024

868024
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: octadecatrienoyl carnitine (C18:3Crn, n3)

901238
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stoichiometry: 1.0
species: 865883

871542
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: 7alpha-Hydroxycholest-4-en-3-one

906101
type: Reaction
reactant: 906126
product: 906162
name: cytidine deaminase
reactant: 906113
fast: false
notes: GENE_ASSOCIATION: (NM_020661.1 or NM_001785.2) GENE_LIST: NM_001785.2 NM_020661.1 SUBSYSTEM: Pyrimidine Catabolism
product: 906150
reversible: false
reactant: 906138
kinetic law: 906175

906126
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stoichiometry: 1.0
species: 867216

906162
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stoichiometry: 1.0
species: 868976

906113
type: SpeciesReference
stoichiometry: 1.0
species: 865967

865967
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Cytidine

906150
type: SpeciesReference
stoichiometry: 1.0
species: 867842

906138
type: SpeciesReference
stoichiometry: 1.0
species: 867228

906223
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value: 500.0

906211
type: LocalParameter
value: 0.0

906199
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value: 1000.0

906187
type: LocalParameter
value: 0.0

933902
type: Reaction
reversible: false
product: 933975
product: 933963
notes: GENE_ASSOCIATION: (NM_000481.2 and NM_000108.3 and NM_004483.3 and NM_000170.1) GENE_LIST: NM_000108.3 NM_000170.1 NM_000481.2 NM_004483.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 933951
fast: false
product: 933987
name: glycine cleavage system, mitochondrial
reactant: 933927
reactant: 933939
reactant: 933914
kinetic law: 933999

933975
type: SpeciesReference
stoichiometry: 1.0
species: 870461

933963
type: SpeciesReference
stoichiometry: 1.0
species: 870383

933951
type: SpeciesReference
stoichiometry: 1.0
species: 869631

933987
type: SpeciesReference
stoichiometry: 1.0
species: 870500

933927
type: SpeciesReference
stoichiometry: 1.0
species: 870448

933939
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stoichiometry: 1.0
species: 871094

933914
type: SpeciesReference
stoichiometry: 1.0
species: 870104

934047
type: LocalParameter
value: 500.0

934035
type: LocalParameter
value: 0.0

934023
type: LocalParameter
value: 1000.0

934011
type: LocalParameter
value: 0.0

888551
type: Reaction
kinetic law: 888635
reversible: false
reactant: 888563
product: 888623
product: 888611
fast: false
reactant: 888587
name: aminomuconate-semialdehyde dehydrogenase
product: 888599
reactant: 888575
notes: SUBSYSTEM: Tryptophan metabolism

888683
type: LocalParameter
value: 500.0

888671
type: LocalParameter
value: 0.0

888659
type: LocalParameter
value: 1000.0

888647
type: LocalParameter
value: 0.0

888563
type: SpeciesReference
stoichiometry: 1.0
species: 865581

888623
type: SpeciesReference
stoichiometry: 1.0
species: 867806

888611
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species: 867216

888587
type: SpeciesReference
stoichiometry: 1.0
species: 867794

888599
type: SpeciesReference
stoichiometry: 1.0
species: 864965

864965
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 2-Aminomuconate

888575
type: SpeciesReference
stoichiometry: 1.0
species: 867228

939807
type: Reaction
reactant: 939831
reactant: 939855
product: 939867
reversible: false
reactant: 939819
product: 939880
reactant: 939843
name: hydroxysteroid (17-beta) dehydrogenase 4
kinetic law: 939904
notes: GENE_ASSOCIATION: NM_000414.1 GENE_LIST: NM_000414.1 SUBSYSTEM: Bile Acid Biosynthesis
product: 939892
fast: false

939831
type: SpeciesReference
stoichiometry: 1.0
species: 871821

871821
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: H+

939855
type: SpeciesReference
stoichiometry: 1.0
species: 871905

939867
type: SpeciesReference
stoichiometry: 1.0
species: 871688

939819
type: SpeciesReference
stoichiometry: 1.0
species: 871676

871676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA

939880
type: SpeciesReference
stoichiometry: 1.0
species: 871833

939843
type: SpeciesReference
stoichiometry: 1.0
species: 871893

871893
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Nicotinamide adenine dinucleotide phosphate - reduced

939953
type: LocalParameter
value: 500.0

939941
type: LocalParameter
value: 0.0

939929
type: LocalParameter
value: 1000.0

939916
type: LocalParameter
value: 0.0

939892
type: SpeciesReference
stoichiometry: 1.0
species: 871881

871881
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Nicotinamide adenine dinucleotide phosphate

864357
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Glutamine

869860
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosapentaenoyl carnitine (C20:5Crn, n-3)

865182
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 4-Maleylacetoacetate

961781
type: Reaction
reactant: 961805
product: 961817
notes: GENE_ASSOCIATION: NM_014754.1 GENE_LIST: NM_014754.1 SUBSYSTEM: Phospholipid Biosynthesis
reversible: true
reactant: 961793
fast: false
kinetic law: 961842
product: 961830
name: Phosphatidylserine synthase 1, human hepatocyte

961805
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stoichiometry: 0.001
species: 868445

961817
type: SpeciesReference
stoichiometry: 0.001
species: 868157

961793
type: SpeciesReference
stoichiometry: 1.0
species: 865761

961890
type: LocalParameter
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961878
type: LocalParameter
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961866
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value: 1000.0

961854
type: LocalParameter
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961830
type: SpeciesReference
stoichiometry: 1.0
species: 868553

934541
type: Reaction
kinetic law: 934601
name: glycine reversible transport via sodium symport, blood
product: 934589
reversible: true
notes: GENE_ASSOCIATION: (NM_001077484.1 or NM_030674.2 or NM_018976.3 or NM_018018.2 or NM_007231.1) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
fast: false
reactant: 934553
reactant: 934565
product: 934577

934649
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value: 0.0

934637
type: LocalParameter
value: 0.0

934625
type: LocalParameter
value: 1000.0

934613
type: LocalParameter
value: -1000.0

934589
type: SpeciesReference
stoichiometry: 1.0
species: 867782

934553
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stoichiometry: 1.0
species: 864381

934565
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stoichiometry: 1.0
species: 864576

934577
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species: 867095

875329
type: Reaction
kinetic law: 875365
product: 875353
reactant: 875341
fast: false
reversible: true
name: eicosatrienoate (C20:3,n-9) exchange

875414
type: LocalParameter
value: 500.0

875402
type: LocalParameter
value: 0.0

875390
type: LocalParameter
value: 1000.0

875377
type: LocalParameter
value: 0.0

875353
type: SpeciesReference
stoichiometry: 1.0
species: 872242

875341
type: SpeciesReference
stoichiometry: 1.0
species: 864260

872679
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: phe_L_b

871640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: AMP

872545
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: met_L_b

948802
type: Reaction
product: 948850
reactant: 948826
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018138.1) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_002512.2) or NM_013330.3 or NM_005793.3 or NM_197972.1 or (NM_000269.2 and NM_001018137.1) or (NM_001018137.1 and NM_198175.1) or NM_002513.2 or (NM_001018138.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_002512.2 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotides
name: nucleoside-diphosphate kinase (ATP:GDP)
product: 948838
fast: false
reactant: 948814
kinetic law: 948862
reversible: true

948850
type: SpeciesReference
stoichiometry: 1.0
species: 867204

948826
type: SpeciesReference
stoichiometry: 1.0
species: 867023

948838
type: SpeciesReference
stoichiometry: 1.0
species: 865460

948814
type: SpeciesReference
stoichiometry: 1.0
species: 865641

948910
type: LocalParameter
value: 0.0

948898
type: LocalParameter
value: 0.0

948886
type: LocalParameter
value: 1000.0

948874
type: LocalParameter
value: -1000.0

962144
type: Reaction
name: pyruvate kinase
reactant: 962180
reactant: 962168
reactant: 962156
notes: GENE_ASSOCIATION: (NM_182470.1 or NM_182471.1 or NM_002654.3 or NM_181871.2 or NM_000298.4) GENE_LIST: NM_000298.4 NM_002654.3 NM_181871.2 NM_182470.1 NM_182471.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
product: 962192
product: 962205
kinetic law: 962217
reversible: false

962180
type: SpeciesReference
stoichiometry: 1.0
species: 868217

868217
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Phosphoenolpyruvate

962168
type: SpeciesReference
stoichiometry: 1.0
species: 867216

962156
type: SpeciesReference
stoichiometry: 1.0
species: 865460

962192
type: SpeciesReference
stoichiometry: 1.0
species: 865641

962205
type: SpeciesReference
stoichiometry: 1.0
species: 868493

962265
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value: 500.0

962253
type: LocalParameter
value: 0.0

962241
type: LocalParameter
value: 1000.0

962229
type: LocalParameter
value: 0.0

872170
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: dcspea6_b

945423
type: Reaction
notes: GENE_ASSOCIATION: (NM_000429.2 or (NM_005911.4 and NM_182796.1) or (NM_005911.4 and NM_013283.3)) GENE_LIST: NM_000429.2 NM_005911.4 NM_013283.3 NM_182796.1 SUBSYSTEM: Glycine and Serine Metabolism
product: 945495
product: 945471
product: 945483
reversible: false
kinetic law: 945507
reactant: 945447
reactant: 945459
fast: false
name: methionine adenosyltransferase
reactant: 945435

945495
type: SpeciesReference
stoichiometry: 1.0
species: 868361

945471
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stoichiometry: 1.0
species: 865544

945483
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species: 868265

945555
type: LocalParameter
value: 500.0

945543
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value: 0.0

945531
type: LocalParameter
value: 1000.0

945519
type: LocalParameter
value: 0.0

945447
type: SpeciesReference
stoichiometry: 1.0
species: 867228

945459
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stoichiometry: 1.0
species: 867686

945435
type: SpeciesReference
stoichiometry: 1.0
species: 865641

876588
type: Reaction
kinetic law: 876624
product: 876612
reactant: 876600
fast: false
reversible: true
name: H2O exchange

876673
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value: 0.0

876661
type: LocalParameter
value: 0.0

876649
type: LocalParameter
value: 1000.0

876636
type: LocalParameter
value: -1000.0

876612
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stoichiometry: 1.0
species: 872387

872387
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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: h2o_b

876600
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species: 864417

879020
type: Reaction
kinetic law: 879056
product: 879044
reactant: 879032
fast: false
reversible: true
name: (R)-Pantothenate exchange

879104
type: LocalParameter
value: 500.0

879092
type: LocalParameter
value: 0.0

879080
type: LocalParameter
value: 1000.0

879068
type: LocalParameter
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879044
type: SpeciesReference
stoichiometry: 1.0
species: 872703

879032
type: SpeciesReference
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species: 864723

877167
type: Reaction
kinetic law: 877203
product: 877191
reactant: 877179
fast: false
reversible: true
name: L-Isoleucine exchange

877254
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value: -0.00481983

877241
type: LocalParameter
value: 0.0

877228
type: LocalParameter
value: 0.0

877215
type: LocalParameter
value: -0.00963966

877191
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stoichiometry: 1.0
species: 872471

877179
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species: 864491

864491
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initial amount: NaN
in compartment: 864005
name: L-Isoleucine

872098
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: chol_b

954440
type: Reaction
kinetic law: 954512
product: 954500
reactant: 954464
name: pyrroline-5-carboxylate reductase
fast: false
reactant: 954452
reversible: false
notes: GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Amino Acid Metabolism
reactant: 954476
product: 954488

954560
type: LocalParameter
value: 500.0

954548
type: LocalParameter
value: 0.0

954536
type: LocalParameter
value: 1000.0

954524
type: LocalParameter
value: 0.0

954500
type: SpeciesReference
stoichiometry: 1.0
species: 868421

954464
type: SpeciesReference
stoichiometry: 2.0
species: 867216

954452
type: SpeciesReference
stoichiometry: 1.0
species: 864941

864941
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 1-Pyrroline-5-carboxylate

954476
type: SpeciesReference
stoichiometry: 1.0
species: 867830

954488
type: SpeciesReference
stoichiometry: 1.0
species: 867818

928524
type: Reaction
kinetic law: 928572
product: 928560
reactant: 928548
reactant: 928536
notes: GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citrate Cycle (TCA)
fast: false
reversible: true
name: fumarase, mitochondrial

928620
type: LocalParameter
value: 0.0

928608
type: LocalParameter
value: 0.0

928596
type: LocalParameter
value: 1000.0

928584
type: LocalParameter
value: -1000.0

928560
type: SpeciesReference
stoichiometry: 1.0
species: 870359

928548
type: SpeciesReference
stoichiometry: 1.0
species: 870152

928536
type: SpeciesReference
stoichiometry: 1.0
species: 870018

920109
type: Reaction
reactant: 920121
product: 920218
product: 920194
product: 920206
reactant: 920157
reversible: false
reactant: 920169
product: 920182
name: Beta oxidation of odd chain fatty acid
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and ... GENE_LIST: ... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 920145
reactant: 920133
kinetic law: 920243
fast: false
product: 920231

920121
type: SpeciesReference
stoichiometry: 1.0
species: 869643

920218
type: SpeciesReference
stoichiometry: 1.0
species: 870461

920194
type: SpeciesReference
stoichiometry: 1.0
species: 869957

920206
type: SpeciesReference
stoichiometry: 1.0
species: 870140

920157
type: SpeciesReference
stoichiometry: 1.0
species: 870251

920169
type: SpeciesReference
stoichiometry: 1.0
species: 870448

920182
type: SpeciesReference
stoichiometry: 1.0
species: 869412

920145
type: SpeciesReference
stoichiometry: 1.0
species: 870152

920133
type: SpeciesReference
stoichiometry: 1.0
species: 869945

920291
type: LocalParameter
value: 500.0

920279
type: LocalParameter
value: 0.0

920267
type: LocalParameter
value: 1000.0

920255
type: LocalParameter
value: 0.0

920231
type: SpeciesReference
stoichiometry: 1.0
species: 870731

941772
type: Reaction
fast: false
reactant: 941796
product: 941820
product: 941832
kinetic law: 941844
name: kynureninase
product: 941808
notes: GENE_ASSOCIATION: (NM_001032998.1 or NM_003937.2) GENE_LIST: NM_001032998.1 NM_003937.2 SUBSYSTEM: Tryptophan metabolism
reversible: false
reactant: 941784

941796
type: SpeciesReference
stoichiometry: 1.0
species: 867348

941820
type: SpeciesReference
stoichiometry: 1.0
species: 865532

941832
type: SpeciesReference
stoichiometry: 1.0
species: 867216

941892
type: LocalParameter
value: 500.0

941880
type: LocalParameter
value: 0.0

941868
type: LocalParameter
value: 1000.0

941856
type: LocalParameter
value: 0.0

941808
type: SpeciesReference
stoichiometry: 1.0
species: 865050

865050
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 3-Hydroxyanthranilate

941784
type: SpeciesReference
stoichiometry: 1.0
species: 867228

876007
type: Reaction
kinetic law: 876044
product: 876031
reactant: 876019
fast: false
reversible: true
name: D-Glucose exchange

876092
type: LocalParameter
value: -0.5

876080
type: LocalParameter
value: 0.0

876068
type: LocalParameter
value: 0.0

876056
type: LocalParameter
value: -1.0

876031
type: SpeciesReference
stoichiometry: 1.0
species: 872327

872327
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: glc_D_b

876019
type: SpeciesReference
stoichiometry: 1.0
species: 864345

874748
type: Reaction
kinetic law: 874785
product: 874773
reactant: 874761
fast: false
reversible: true
name: docosapentaenoate (C22:5, n-6) exchange

874833
type: LocalParameter
value: 500.0

874821
type: LocalParameter
value: 0.0

874809
type: LocalParameter
value: 1000.0

874797
type: LocalParameter
value: 0.0

874773
type: SpeciesReference
stoichiometry: 1.0
species: 872170

874761
type: SpeciesReference
stoichiometry: 1.0
species: 864188

970125
type: Reaction
kinetic law: 970173
product: 970161
product: 970149
reactant: 970137
notes: GENE_ASSOCIATION: NM_000375.1 GENE_LIST: NM_000375.1 SUBSYSTEM: Heme Biosynthesis
fast: false
reversible: false
name: uroporphyrinogen-III synthase

970222
type: LocalParameter
value: 500.0

970210
type: LocalParameter
value: 0.0

970198
type: LocalParameter
value: 1000.0

970185
type: LocalParameter
value: 0.0

970161
type: SpeciesReference
stoichiometry: 1.0
species: 868939

868939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Uroporphyrinogen III

970149
type: SpeciesReference
stoichiometry: 1.0
species: 867228

970137
type: SpeciesReference
stoichiometry: 1.0
species: 867360

969013
type: Reaction
kinetic law: 969049
product: 969037
reactant: 969025
notes: GENE_ASSOCIATION: (NM_012244.2 or NM_182728.1 or NM_003486.5 or NM_018593.3) GENE_LIST: NM_003486.5 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tryptophan transport, blood

969097
type: LocalParameter
value: 0.0

969085
type: LocalParameter
value: 0.0

969073
type: LocalParameter
value: 1000.0

969061
type: LocalParameter
value: -1000.0

969037
type: SpeciesReference
stoichiometry: 1.0
species: 868830

969025
type: SpeciesReference
stoichiometry: 1.0
species: 864808

864808
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Tryptophan

961308
type: Reaction
notes: GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Biosynthesis
kinetic law: 961370
reactant: 961332
product: 961344
name: phosphatidylserine decarboxylase, human hepatocyte
fast: false
reversible: false
product: 961357
reactant: 961320

961422
type: LocalParameter
value: 500.0

961409
type: LocalParameter
value: 0.0

961396
type: LocalParameter
value: 1000.0

961383
type: LocalParameter
value: 0.0

961332
type: SpeciesReference
stoichiometry: 0.001
species: 868445

961344
type: SpeciesReference
stoichiometry: 1.0
species: 865871

961357
type: SpeciesReference
stoichiometry: 0.001
species: 868205

961320
type: SpeciesReference
stoichiometry: 1.0
species: 867216

933176
type: Reaction
reactant: 933188
name: glutaminase, mitochondrial
notes: GENE_ASSOCIATION: (NM_013267.2 or NM_014905.2) GENE_LIST: NM_013267.2 NM_014905.2 SUBSYSTEM: Glutamate metabolism
fast: false
reactant: 933200
product: 933225
reversible: false
kinetic law: 933237
product: 933213

933188
type: SpeciesReference
stoichiometry: 1.0
species: 870042

870042
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Glutamine

933200
type: SpeciesReference
stoichiometry: 1.0
species: 870152

933225
type: SpeciesReference
stoichiometry: 1.0
species: 870500

933286
type: LocalParameter
value: 500.0

933273
type: LocalParameter
value: 0.0

933261
type: LocalParameter
value: 1000.0

933249
type: LocalParameter
value: 0.0

933213
type: SpeciesReference
stoichiometry: 1.0
species: 870055

893543
type: Reaction
fast: false
kinetic law: 893615
product: 893579
product: 893603
reversible: true
reactant: 893555
product: 893591
reactant: 893567
name: CDP-diacylglycerol--serine O-phosphatidyltransferae, mitochondrial, human hepatocyte
notes: GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Biosynthesis

893663
type: LocalParameter
value: 0.0

893651
type: LocalParameter
value: 0.0

893639
type: LocalParameter
value: 1000.0

893627
type: LocalParameter
value: -1000.0

893579
type: SpeciesReference
stoichiometry: 1.0
species: 869619

869619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: CMP

893603
type: SpeciesReference
stoichiometry: 0.001
species: 870779

893555
type: SpeciesReference
stoichiometry: 0.001
species: 869571

869571
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: CDPdiacylglycerol, human hepatocyte

893591
type: SpeciesReference
stoichiometry: 1.0
species: 870140

893567
type: SpeciesReference
stoichiometry: 1.0
species: 870116

907926
type: Reaction
kinetic law: 907962
product: 907950
reactant: 907938
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: docosahexaenoate (C22:6, n-3) transport

908010
type: LocalParameter
value: 0.0

907998
type: LocalParameter
value: 0.0

907986
type: LocalParameter
value: 1000.0

907974
type: LocalParameter
value: -1000.0

907950
type: SpeciesReference
stoichiometry: 1.0
species: 866088

907938
type: SpeciesReference
stoichiometry: 1.0
species: 864163

955901
type: Reaction
kinetic law: 955938
product: 955925
reactant: 955913
notes: GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: glucose-6-phosphate isomerase

955986
type: LocalParameter
value: 0.0

955974
type: LocalParameter
value: 0.0

955962
type: LocalParameter
value: 1000.0

955950
type: LocalParameter
value: -1000.0

955925
type: SpeciesReference
stoichiometry: 1.0
species: 866756

955913
type: SpeciesReference
stoichiometry: 1.0
species: 866962

909852
type: Reaction
reactant: 909876
name: fatty acyl-CoA desaturase (C20:4CoA, n3 -> C20:5CoA, n3)
reactant: 909889
reactant: 909864
fast: false
product: 909913
kinetic law: 909952
product: 909926
reversible: false
reactant: 909901
product: 909939
notes: GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis

909876
type: SpeciesReference
stoichiometry: 1.0
species: 867216

909889
type: SpeciesReference
stoichiometry: 1.0
species: 867806

909864
type: SpeciesReference
stoichiometry: 1.0
species: 866695

909913
type: SpeciesReference
stoichiometry: 1.0
species: 866610

910004
type: LocalParameter
value: 500.0

909991
type: LocalParameter
value: 0.0

909978
type: LocalParameter
value: 1000.0

909965
type: LocalParameter
value: 0.0

909926
type: SpeciesReference
stoichiometry: 2.0
species: 867228

909901
type: SpeciesReference
stoichiometry: 1.0
species: 867854

909939
type: SpeciesReference
stoichiometry: 1.0
species: 867794

865315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 6-Pyruvoyl-5,6,7,8-tetrahydropterin

885028
type: Reaction
kinetic law: 885076
product: 885064
product: 885052
reactant: 885040
notes: GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Purine Metabolism
fast: false
reversible: true
name: adenylsuccinate lyase

885125
type: LocalParameter
value: 0.0

885113
type: LocalParameter
value: 0.0

885100
type: LocalParameter
value: 1000.0

885088
type: LocalParameter
value: -1000.0

885064
type: SpeciesReference
stoichiometry: 1.0
species: 866924

885052
type: SpeciesReference
stoichiometry: 1.0
species: 865568

885040
type: SpeciesReference
stoichiometry: 1.0
species: 866015

866015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: N6-(1,2-Dicarboxyethyl)-AMP

958509
type: Reaction
product: 958545
reversible: false
reactant: 958533
reactant: 958521
notes: GENE_ASSOCIATION: NM_021129.3 GENE_LIST: NM_021129.3 SUBSYSTEM: Oxidative Phosphorylation
kinetic law: 958569
fast: false
name: inorganic diphosphatase
product: 958557

958545
type: SpeciesReference
stoichiometry: 1.0
species: 867216

958533
type: SpeciesReference
stoichiometry: 1.0
species: 868361

958521
type: SpeciesReference
stoichiometry: 1.0
species: 867228

958617
type: LocalParameter
value: 500.0

958605
type: LocalParameter
value: 0.0

958593
type: LocalParameter
value: 1000.0

958581
type: LocalParameter
value: 0.0

958557
type: SpeciesReference
stoichiometry: 2.0
species: 868265

870587
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: octadecadienoyl carnitine (C18:2Crn, n-6)

942748
type: Reaction
product: 942797
reactant: 942760
reactant: 942772
reversible: true
fast: false
notes: GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
kinetic law: 942809
product: 942784
name: leucine transaminase, mitochondrial

942797
type: SpeciesReference
stoichiometry: 1.0
species: 870055

942760
type: SpeciesReference
stoichiometry: 1.0
species: 869448

942772
type: SpeciesReference
stoichiometry: 1.0
species: 870335

942857
type: LocalParameter
value: 0.0

942845
type: LocalParameter
value: 0.0

942833
type: LocalParameter
value: 1000.0

942821
type: LocalParameter
value: -1000.0

942784
type: SpeciesReference
stoichiometry: 1.0
species: 869327

912055
type: Reaction
kinetic law: 912103
product: 912091
reactant: 912079
reactant: 912067
notes: SUBSYSTEM: Valine degradation
fast: false
reversible: true
name: enoyl-CoA hydratase, mitochondrial

912151
type: LocalParameter
value: 0.0

912139
type: LocalParameter
value: 0.0

912127
type: LocalParameter
value: 1000.0

912115
type: LocalParameter
value: -1000.0

912091
type: SpeciesReference
stoichiometry: 1.0
species: 870212

912079
type: SpeciesReference
stoichiometry: 1.0
species: 870152

912067
type: SpeciesReference
stoichiometry: 1.0
species: 869158

970947
type: Reaction
fast: false
reactant: 970971
product: 971008
reactant: 970959
product: 970996
notes: GENE_ASSOCIATION: (NM_012474.3 or NM_031432.1) GENE_LIST: NM_012474.3 NM_031432.1 SUBSYSTEM: Pyrimidine Metabolism
name: uridine kinase (ITP:Uridine)
kinetic law: 971020
product: 970983
reversible: false

970971
type: SpeciesReference
stoichiometry: 1.0
species: 868976

971008
type: SpeciesReference
stoichiometry: 1.0
species: 868927

970959
type: SpeciesReference
stoichiometry: 1.0
species: 867541

970996
type: SpeciesReference
stoichiometry: 1.0
species: 867456

971068
type: LocalParameter
value: 500.0

971056
type: LocalParameter
value: 0.0

971044
type: LocalParameter
value: 1000.0

971032
type: LocalParameter
value: 0.0

970983
type: SpeciesReference
stoichiometry: 1.0
species: 867216

872619
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ocdctra3_b

894555
type: Reaction
kinetic law: 894591
product: 894579
reactant: 894567
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: cholesterol ester transport, blood, hepatocyte

894639
type: LocalParameter
value: 0.0

894627
type: LocalParameter
value: 0.0

894615
type: LocalParameter
value: 1000.0

894603
type: LocalParameter
value: -1000.0

894579
type: SpeciesReference
stoichiometry: 1.0
species: 864126

894567
type: SpeciesReference
stoichiometry: 1.0
species: 865799

969109
type: Reaction
kinetic law: 969146
product: 969133
reactant: 969121
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Tetradecanoate (n-C14:0) transport in via uniport

969194
type: LocalParameter
value: 0.0

969182
type: LocalParameter
value: 0.0

969170
type: LocalParameter
value: 1000.0

969158
type: LocalParameter
value: -1000.0

969133
type: SpeciesReference
stoichiometry: 1.0
species: 864820

969121
type: SpeciesReference
stoichiometry: 1.0
species: 868854

913881
type: Reaction
reactant: 913905
notes: GENE_ASSOCIATION: (NM_004457.3 or NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_022977.1 or NM_016234.3 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
kinetic law: 913966
reversible: true
product: 913929
product: 913953
fast: false
reactant: 913893
reactant: 913917
product: 913941
name: fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)

913905
type: SpeciesReference
stoichiometry: 1.0
species: 865883

914014
type: LocalParameter
value: 0.0

914002
type: LocalParameter
value: 0.0

913990
type: LocalParameter
value: 1000.0

913978
type: LocalParameter
value: -1000.0

913929
type: SpeciesReference
stoichiometry: 1.0
species: 865568

913953
type: SpeciesReference
stoichiometry: 1.0
species: 868361

913893
type: SpeciesReference
stoichiometry: 1.0
species: 865641

913917
type: SpeciesReference
stoichiometry: 1.0
species: 867288

913941
type: SpeciesReference
stoichiometry: 1.0
species: 867300

904339
type: Reaction
product: 904375
notes: GENE_ASSOCIATION: NM_000755.2 GENE_LIST: NM_000755.2 SUBSYSTEM: Carnitine Shuttle
product: 904387
name: carnitine O-aceyltransferase, mitochondrial
kinetic law: 904400
reactant: 904351
reactant: 904363
reversible: true
fast: false

904375
type: SpeciesReference
stoichiometry: 1.0
species: 869655

904387
type: SpeciesReference
stoichiometry: 1.0
species: 870851

904448
type: LocalParameter
value: 0.0

904436
type: LocalParameter
value: 0.0

904424
type: LocalParameter
value: 1000.0

904412
type: LocalParameter
value: -1000.0

904351
type: SpeciesReference
stoichiometry: 1.0
species: 869643

904363
type: SpeciesReference
stoichiometry: 1.0
species: 870719

871664
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: Choloyl-CoA

886808
type: Reaction
kinetic law: 886881
reactant: 886820
notes: GENE_ASSOCIATION: NM_005989.2 GENE_LIST: NM_005989.2 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 886832
product: 886869
product: 886856
reversible: false
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
fast: false
reactant: 886844

886929
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886917
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886905
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886893
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886820
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species: 867216

886832
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886869
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species: 869037

869037
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initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

886856
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species: 867818

886844
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species: 869024

910968
type: Reaction
notes: GENE_ASSOCIATION: NM_000320.1 GENE_LIST: NM_000320.1 SUBSYSTEM: Tyrosine metabolism
fast: false
name: dihydropteridine reductase
kinetic law: 911041
reversible: true
reactant: 910992
product: 911029
product: 911017
reactant: 911005
reactant: 910980

911089
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911077
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911065
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value: 1000.0

911053
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910992
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species: 867216

911029
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species: 868734

911017
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species: 867794

911005
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species: 867806

910980
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species: 866222

886017
type: Reaction
fast: false
product: 886065
reactant: 886041
reactant: 886029
kinetic law: 886077
product: 886053
name: phosphoribosylaminoimidazole carboxylase
notes: GENE_ASSOCIATION: (NM_006452.3 or NM_001079525.1 or NM_001079524.1) GENE_LIST: NM_001079524.1 NM_001079525.1 NM_006452.3 SUBSYSTEM: Purine Metabolism
reversible: true

886065
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stoichiometry: 1.0
species: 867216

886041
type: SpeciesReference
stoichiometry: 1.0
species: 865871

886029
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species: 865508

886126
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value: 0.0

886113
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value: 0.0

886101
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value: 1000.0

886089
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886053
type: SpeciesReference
stoichiometry: 1.0
species: 865230

865230
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

953849
type: Reaction
notes: GENE_ASSOCIATION: NM_004391.1 GENE_LIST: NM_004391.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 953873
product: 953909
product: 953921
kinetic law: 953945
reactant: 953897
name: sterol 12-alpha-hydroxylase
reactant: 953885
reactant: 953861
reversible: false
product: 953933
fast: false

953873
type: SpeciesReference
stoichiometry: 1.0
species: 871469

953909
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species: 871397

953921
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species: 871457

953993
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953981
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value: 0.0

953969
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value: 1000.0

953957
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value: 0.0

953897
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stoichiometry: 1.0
species: 871542

953885
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species: 871481

953861
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species: 871385

953933
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species: 871554

961683
type: Reaction
kinetic law: 961719
product: 961707
reactant: 961695
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion

961768
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961756
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value: 0.0

961743
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value: 1000.0

961731
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961707
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stoichiometry: 1.0
species: 868469

961695
type: SpeciesReference
stoichiometry: 1.0
species: 864747

864747
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: pentadecanoate (C15:0)

904701
type: Reaction
reversible: false
reactant: 904737
product: 904749
kinetic law: 904785
notes: GENE_ASSOCIATION: (NM_198324.1 or NM_004077.2) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citric Acid Cycle
name: citrate synthase
product: 904761
fast: false
reactant: 904725
reactant: 904713
product: 904773

904737
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stoichiometry: 1.0
species: 870551

904749
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stoichiometry: 1.0
species: 869583

904833
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value: 500.0

904821
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value: 0.0

904809
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value: 1000.0

904797
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value: 0.0

904761
type: SpeciesReference
stoichiometry: 1.0
species: 869643

904725
type: SpeciesReference
stoichiometry: 1.0
species: 870152

904713
type: SpeciesReference
stoichiometry: 1.0
species: 869412

904773
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stoichiometry: 1.0
species: 870140

963556
type: Reaction
fast: false
product: 963604
reversible: false
reactant: 963580
notes: SUBSYSTEM: Other
product: 963592
kinetic law: 963616
reactant: 963568
name: S-adenosyl-L-methionine methyltransferase

963604
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species: 865472

963580
type: SpeciesReference
stoichiometry: 1.0
species: 868758

963592
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stoichiometry: 1.0
species: 865279

963664
type: LocalParameter
value: 500.0

963652
type: LocalParameter
value: 0.0

963640
type: LocalParameter
value: 1000.0

963628
type: LocalParameter
value: 0.0

963568
type: SpeciesReference
stoichiometry: 1.0
species: 865544

929993
type: Reaction
product: 930065
name: glutamate aspartate carrier, cytosolic/mitochondrial
reactant: 930029
product: 930053
fast: false
reactant: 930005
reactant: 930017
notes: GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
reversible: false
kinetic law: 930077
product: 930041

930065
type: SpeciesReference
stoichiometry: 1.0
species: 870140

930029
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stoichiometry: 1.0
species: 869497

930053
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species: 870055

930005
type: SpeciesReference
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species: 867059

930017
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species: 867216

930125
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value: 500.0

930113
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value: 0.0

930101
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value: 1000.0

930089
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value: 0.0

930041
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stoichiometry: 1.0
species: 865629

961902
type: Reaction
kinetic law: 961950
product: 961938
product: 961926
reactant: 961914
notes: GENE_ASSOCIATION: NM_000317.1 GENE_LIST: NM_000317.1 SUBSYSTEM: Folate Metabolism
fast: false
reversible: false
name: 6-pyruvoyltetrahydropterin synthase

961999
type: LocalParameter
value: 500.0

961986
type: LocalParameter
value: 0.0

961974
type: LocalParameter
value: 1000.0

961962
type: LocalParameter
value: 0.0

961938
type: SpeciesReference
stoichiometry: 1.0
species: 868397

961926
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stoichiometry: 1.0
species: 865315

961914
type: SpeciesReference
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species: 865484

899996
type: Reaction
reactant: 900008
product: 900045
name: hexadecenoyl carnitine transprot (C16:1Crn, n7)
product: 900032
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 900057
reactant: 900020
reversible: true
fast: false

900008
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stoichiometry: 1.0
species: 867312

867312
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: hexadecenoyl carnitine (C16:1Crn, n-7)

900045
type: SpeciesReference
stoichiometry: 1.0
species: 870200

870200
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: hexadecenoyl carnitine (C16:1Crn, n-7)

900032
type: SpeciesReference
stoichiometry: 1.0
species: 865907

900105
type: LocalParameter
value: 0.0

900093
type: LocalParameter
value: 0.0

900081
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value: 1000.0

900069
type: LocalParameter
value: -1000.0

900020
type: SpeciesReference
stoichiometry: 1.0
species: 869655

885246
type: Reaction
notes: GENE_ASSOCIATION: (NM_001126.2 or NM_152328.3 or NM_199165.1) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Purine Metabolism
product: 885306
reactant: 885258
product: 885318
product: 885330
product: 885294
reactant: 885282
reversible: false
fast: false
name: adenylosuccinate synthetase
reactant: 885270
kinetic law: 885342

885306
type: SpeciesReference
stoichiometry: 1.0
species: 867023

885258
type: SpeciesReference
stoichiometry: 1.0
species: 865629

885318
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species: 867216

885330
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stoichiometry: 1.0
species: 868265

885294
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stoichiometry: 1.0
species: 866015

885282
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stoichiometry: 1.0
species: 867504

885270
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stoichiometry: 1.0
species: 867204

885390
type: LocalParameter
value: 500.0

885378
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value: 0.0

885366
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value: 1000.0

885354
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value: 0.0

868433
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: 5-Phospho-alpha-D-ribose 1-diphosphate

935174
type: Reaction
notes: GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
product: 935226
reactant: 935187
reactant: 935200
reversible: false
name: geranyltranstransferase
product: 935213
kinetic law: 935239

935226
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stoichiometry: 1.0
species: 868361

935187
type: SpeciesReference
stoichiometry: 1.0
species: 867167

867167
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Geranyl diphosphate

935200
type: SpeciesReference
stoichiometry: 1.0
species: 867529

867529
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Isopentenyl diphosphate

935213
type: SpeciesReference
stoichiometry: 1.0
species: 866900

935290
type: LocalParameter
value: 500.0

935277
type: LocalParameter
value: 0.0

935265
type: LocalParameter
value: 1000.0

935252
type: LocalParameter
value: 0.0

876878
type: Reaction
kinetic law: 876914
product: 876902
reactant: 876890
fast: false
reversible: true
name: hexadecenoate (C16:1, n-7) exchange

876962
type: LocalParameter
value: 500.0

876950
type: LocalParameter
value: 0.0

876938
type: LocalParameter
value: 1000.0

876926
type: LocalParameter
value: 0.0

876902
type: SpeciesReference
stoichiometry: 1.0
species: 872435

876890
type: SpeciesReference
stoichiometry: 1.0
species: 864454

883666
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (NM_001101667.1 or NM_003500.2 or NM_003501.1) GENE_LIST: NM_001101667.1 NM_003500.2 NM_003501.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 883690
product: 883739
product: 883714
name: acyl-Coenzyme A oxidase 2, branched chain
reactant: 883678
kinetic law: 883751
product: 883726
fast: false
reactant: 883702

883690
type: SpeciesReference
stoichiometry: 1.0
species: 871785

883739
type: SpeciesReference
stoichiometry: 2.0
species: 871833

883714
type: SpeciesReference
stoichiometry: 1.0
species: 871676

883678
type: SpeciesReference
stoichiometry: 1.0
species: 871713

883800
type: LocalParameter
value: 500.0

883788
type: LocalParameter
value: 0.0

883776
type: LocalParameter
value: 1000.0

883764
type: LocalParameter
value: 0.0

883726
type: SpeciesReference
stoichiometry: 1.0
species: 871773

871773
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863993
name: FAD

883702
type: SpeciesReference
stoichiometry: 1.0
species: 871905

894844
type: Reaction
kinetic law: 894880
product: 894868
reactant: 894856
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: cholestenol delta-isomerase

894928
type: LocalParameter
value: 0.0

894916
type: LocalParameter
value: 0.0

894904
type: LocalParameter
value: 1000.0

894892
type: LocalParameter
value: -1000.0

894868
type: SpeciesReference
stoichiometry: 1.0
species: 871275

894856
type: SpeciesReference
stoichiometry: 1.0
species: 871579

871579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863981
name: Zymosterol

908022
type: Reaction
kinetic law: 908058
product: 908046
reactant: 908034
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Docosapentaenoate (C22:5, n-3)

908106
type: LocalParameter
value: 0.0

908094
type: LocalParameter
value: 0.0

908082
type: LocalParameter
value: 1000.0

908070
type: LocalParameter
value: -1000.0

908046
type: SpeciesReference
stoichiometry: 1.0
species: 866101

908034
type: SpeciesReference
stoichiometry: 1.0
species: 864175

892020
type: Reaction
fast: false
product: 892080
reactant: 892032
kinetic law: 892092
reactant: 892044
product: 892056
name: C-3 sterol dehydrogenase NADPH, (4-methylzymosterol)
notes: GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Biosynthesis
reversible: false
product: 892068

892080
type: SpeciesReference
stoichiometry: 1.0
species: 871469

892032
type: SpeciesReference
stoichiometry: 1.0
species: 871203

892140
type: LocalParameter
value: 500.0

892128
type: LocalParameter
value: 0.0

892116
type: LocalParameter
value: 1000.0

892104
type: LocalParameter
value: 0.0

892044
type: SpeciesReference
stoichiometry: 1.0
species: 871457

892056
type: SpeciesReference
stoichiometry: 1.0
species: 871215

892068
type: SpeciesReference
stoichiometry: 1.0
species: 871300

890582
type: Reaction
kinetic law: 890643
fast: false
name: L-aspartate transport, blood
reactant: 890594
product: 890631
notes: GENE_ASSOCIATION: (NM_004170.4 or NM_004171.2 or NM_004172.3 or NM_005071.1) GENE_LIST: NM_004170.4 NM_004171.2 NM_004172.3 NM_005071.1 SUBSYSTEM: Transport, Extracellular
product: 890619
reactant: 890607
reversible: true

890692
type: LocalParameter
value: 0.0

890680
type: LocalParameter
value: 0.0

890668
type: LocalParameter
value: 1000.0

890655
type: LocalParameter
value: -1000.0

890594
type: SpeciesReference
stoichiometry: 1.0
species: 864102

864102
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: L-Aspartate

890631
type: SpeciesReference
stoichiometry: 1.0
species: 867782

890619
type: SpeciesReference
stoichiometry: 1.0
species: 865629

890607
type: SpeciesReference
stoichiometry: 1.0
species: 864576

900358
type: Reaction
reactant: 900370
reactant: 900382
name: pentadecanoyl carnitine transferase (C17:0CoA), mitochondrial
fast: false
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 900394
kinetic law: 900418
reversible: true
product: 900406

900370
type: SpeciesReference
stoichiometry: 1.0
species: 867420

867420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: heptadecanoyl carnitine (C17:0Crn)

900382
type: SpeciesReference
stoichiometry: 1.0
species: 869655

900394
type: SpeciesReference
stoichiometry: 1.0
species: 865907

900467
type: LocalParameter
value: 0.0

900455
type: LocalParameter
value: 0.0

900443
type: LocalParameter
value: 1000.0

900430
type: LocalParameter
value: -1000.0

900406
type: SpeciesReference
stoichiometry: 1.0
species: 870263

945158
type: Reaction
kinetic law: 945230
product: 945206
product: 945218
notes: GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Pyruvate Metabolism
reversible: true
reactant: 945182
product: 945194
name: malic enzyme (NADP)
fast: false
reactant: 945170

945279
type: LocalParameter
value: 0.0

945267
type: LocalParameter
value: 0.0

945254
type: LocalParameter
value: 1000.0

945242
type: LocalParameter
value: -1000.0

945206
type: SpeciesReference
stoichiometry: 1.0
species: 867830

945218
type: SpeciesReference
stoichiometry: 1.0
species: 868493

945182
type: SpeciesReference
stoichiometry: 1.0
species: 867818

945194
type: SpeciesReference
stoichiometry: 1.0
species: 865871

945170
type: SpeciesReference
stoichiometry: 1.0
species: 867626

882967
type: Reaction
fast: false
product: 883015
product: 883003
reversible: true
name: acyl-CoA dehydrogenase, mitochondrial
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 882991
kinetic law: 883027
reactant: 882979

883015
type: SpeciesReference
stoichiometry: 1.0
species: 869957

883003
type: SpeciesReference
stoichiometry: 1.0
species: 869158

882991
type: SpeciesReference
stoichiometry: 1.0
species: 870287

870287
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: Isobutyryl-CoA

883075
type: LocalParameter
value: 0.0

883063
type: LocalParameter
value: 0.0

883051
type: LocalParameter
value: 1000.0

883039
type: LocalParameter
value: -1000.0

882979
type: SpeciesReference
stoichiometry: 1.0
species: 869945

947221
type: Reaction
name: 3-Methyl-2-oxobutanoate dehydrogenase, mitochondrial
product: 947293
product: 947281
reactant: 947233
fast: false
kinetic law: 947305
reactant: 947257
reactant: 947245
reversible: false
product: 947269
notes: GENE_ASSOCIATION: (((NM_000709.2 and NM_183050.1) and NM_001918.1 and NM_000108.3) or ((NM_000056.2 and NM_000709.2) and NM_001918.1 and NM_000108.3)) GENE_LIST: NM_000056.2 NM_000108.3 NM_000709.2 NM_001918.1 NM_183050.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation

947293
type: SpeciesReference
stoichiometry: 1.0
species: 870461

947281
type: SpeciesReference
stoichiometry: 1.0
species: 870323

947233
type: SpeciesReference
stoichiometry: 1.0
species: 869327

947353
type: LocalParameter
value: 500.0

947341
type: LocalParameter
value: 0.0

947329
type: LocalParameter
value: 1000.0

947317
type: LocalParameter
value: 0.0

947257
type: SpeciesReference
stoichiometry: 1.0
species: 870448

947245
type: SpeciesReference
stoichiometry: 1.0
species: 869643

947269
type: SpeciesReference
stoichiometry: 1.0
species: 869631

895860
type: Reaction
product: 895920
product: 895908
notes: GENE_ASSOCIATION: NM_000097.4 GENE_LIST: NM_000097.4 SUBSYSTEM: Heme Biosynthesis
name: coproporphyrinogen oxidase
reactant: 895884
reactant: 895872
product: 895932
reactant: 895896
kinetic law: 895944
fast: false
reversible: false

895920
type: SpeciesReference
stoichiometry: 2.0
species: 867228

895908
type: SpeciesReference
stoichiometry: 2.0
species: 865871

895884
type: SpeciesReference
stoichiometry: 2.0
species: 867216

895872
type: SpeciesReference
stoichiometry: 1.0
species: 865895

865895
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Coproporphyrinogen III

895932
type: SpeciesReference
stoichiometry: 1.0
species: 868385

895896
type: SpeciesReference
stoichiometry: 1.0
species: 867854

895992
type: LocalParameter
value: 500.0

895980
type: LocalParameter
value: 0.0

895968
type: LocalParameter
value: 1000.0

895956
type: LocalParameter
value: 0.0

889721
type: Reaction
product: 889770
fast: false
reactant: 889746
reversible: true
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Pyrimidine Biosynthesis
name: aspartate carbamoyltransferase (reversible)
product: 889758
reactant: 889734
kinetic law: 889794
product: 889782

889770
type: SpeciesReference
stoichiometry: 1.0
species: 867216

889746
type: SpeciesReference
stoichiometry: 1.0
species: 865689

889758
type: SpeciesReference
stoichiometry: 1.0
species: 865677

889734
type: SpeciesReference
stoichiometry: 1.0
species: 865629

889842
type: LocalParameter
value: 0.0

889830
type: LocalParameter
value: 0.0

889818
type: LocalParameter
value: 1000.0

889806
type: LocalParameter
value: -1000.0

889782
type: SpeciesReference
stoichiometry: 1.0
species: 868265

899395
type: Reaction
reactant: 899407
fast: false
product: 899443
kinetic law: 899455
name: carnitine eicosanoyltransferase (C20:0Crn)
reactant: 899419
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_001876.2 or NM_152245.1 or NM_152359.1 or NM_004377.2 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 899431
reversible: true

899407
type: SpeciesReference
stoichiometry: 1.0
species: 865907

899443
type: SpeciesReference
stoichiometry: 1.0
species: 866476

899503
type: LocalParameter
value: 0.0

899491
type: LocalParameter
value: 0.0

899479
type: LocalParameter
value: 1000.0

899467
type: LocalParameter
value: -1000.0

899419
type: SpeciesReference
stoichiometry: 1.0
species: 866464

899431
type: SpeciesReference
stoichiometry: 1.0
species: 865883

867011
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: glycocholate

952080
type: Reaction
kinetic law: 952116
product: 952104
reactant: 952092
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecadienoate (C18:2, n-6) transport

952164
type: LocalParameter
value: 0.0

952152
type: LocalParameter
value: 0.0

952140
type: LocalParameter
value: 1000.0

952128
type: LocalParameter
value: -1000.0

952104
type: SpeciesReference
stoichiometry: 1.0
species: 867940

952092
type: SpeciesReference
stoichiometry: 1.0
species: 864662

870887
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: L-Proline

912757
type: Reaction
kinetic law: 912795
product: 912782
reactant: 912770
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatetraenoate (C20:4, n-3) transport

912843
type: LocalParameter
value: 0.0

912831
type: LocalParameter
value: 0.0

912819
type: LocalParameter
value: 1000.0

912807
type: LocalParameter
value: -1000.0

912782
type: SpeciesReference
stoichiometry: 1.0
species: 866548

866548
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosatetraenoate (C20:4, n-3)

912770
type: SpeciesReference
stoichiometry: 1.0
species: 864272

864272
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: eicosatetraenoate (C20:4, n-3)

911222
type: Reaction
kinetic law: 911258
product: 911246
reactant: 911234
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: dimethylallyl diphosphate transport, peroxisome

911306
type: LocalParameter
value: 0.0

911294
type: LocalParameter
value: 0.0

911282
type: LocalParameter
value: 1000.0

911270
type: LocalParameter
value: -1000.0

911246
type: SpeciesReference
stoichiometry: 1.0
species: 866259

866259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Dimethylallyl diphosphate

911234
type: SpeciesReference
stoichiometry: 1.0
species: 871761

898060
type: Reaction
product: 898099
reactant: 898073
kinetic law: 898125
product: 898112
reversible: true
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosatetraenoyltransferase (C20:5Crn, n3), mitochondrial
reactant: 898086
fast: false

898099
type: SpeciesReference
stoichiometry: 1.0
species: 869643

898073
type: SpeciesReference
stoichiometry: 1.0
species: 869655

898178
type: LocalParameter
value: 0.0

898165
type: LocalParameter
value: 0.0

898151
type: LocalParameter
value: 1000.0

898138
type: LocalParameter
value: -1000.0

898112
type: SpeciesReference
stoichiometry: 1.0
species: 869860

898086
type: SpeciesReference
stoichiometry: 1.0
species: 869848

869848
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863969
name: eicosapentaenoyl-CoA (C20:5CoA, n-3)

963146
type: Reaction
kinetic law: 963182
product: 963170
reactant: 963158
notes: GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribose-5-phosphate isomerase

963230
type: LocalParameter
value: 0.0

963218
type: LocalParameter
value: 0.0

963206
type: LocalParameter
value: 1000.0

963194
type: LocalParameter
value: -1000.0

963170
type: SpeciesReference
stoichiometry: 1.0
species: 868517

963158
type: SpeciesReference
stoichiometry: 1.0
species: 868505

971513
type: Reaction
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
reactant: 971537
reversible: false
product: 971561
product: 971573
name: Vesicular ATPase, endoplasmic reticulum
product: 971549
fast: false
reactant: 971525
kinetic law: 971585

971537
type: SpeciesReference
stoichiometry: 1.0
species: 867228

971561
type: SpeciesReference
stoichiometry: 1.0
species: 868265

971573
type: SpeciesReference
stoichiometry: 1.0
species: 871385

971549
type: SpeciesReference
stoichiometry: 1.0
species: 865460

971525
type: SpeciesReference
stoichiometry: 1.0
species: 865641

971633
type: LocalParameter
value: 500.0

971621
type: LocalParameter
value: 0.0

971609
type: LocalParameter
value: 1000.0

971597
type: LocalParameter
value: 0.0

896850
type: Reaction
kinetic law: 896910
reactant: 896862
reversible: true
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 896886
product: 896898
name: carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
reactant: 896874
fast: false

896959
type: LocalParameter
value: 0.0

896947
type: LocalParameter
value: 0.0

896935
type: LocalParameter
value: 1000.0

896923
type: LocalParameter
value: -1000.0

896862
type: SpeciesReference
stoichiometry: 1.0
species: 869655

896886
type: SpeciesReference
stoichiometry: 1.0
species: 869643

896898
type: SpeciesReference
stoichiometry: 1.0
species: 869763

896874
type: SpeciesReference
stoichiometry: 1.0
species: 869739

900117
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152359.1 or NM_152246.1 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine pentadecanoyltransferase (C17:0Crn)
fast: false
reactant: 900141
product: 900154
reactant: 900129
kinetic law: 900178
product: 900166

900141
type: SpeciesReference
stoichiometry: 1.0
species: 867408

900154
type: SpeciesReference
stoichiometry: 1.0
species: 865883

900129
type: SpeciesReference
stoichiometry: 1.0
species: 865907

900226
type: LocalParameter
value: 0.0

900214
type: LocalParameter
value: 0.0

900202
type: LocalParameter
value: 1000.0

900190
type: LocalParameter
value: -1000.0

900166
type: SpeciesReference
stoichiometry: 1.0
species: 867420

929897
type: Reaction
kinetic law: 929933
product: 929921
reactant: 929909
notes: GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion

929981
type: LocalParameter
value: 0.0

929969
type: LocalParameter
value: 0.0

929957
type: LocalParameter
value: 1000.0

929945
type: LocalParameter
value: -1000.0

929921
type: SpeciesReference
stoichiometry: 1.0
species: 871361

929909
type: SpeciesReference
stoichiometry: 1.0
species: 866962

883208
type: Reaction
product: 883245
notes: GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Pyruvate Metabolism
name: acetyl-CoA hydrolase
reactant: 883233
fast: false
reactant: 883220
kinetic law: 883281
product: 883257
reversible: false
product: 883269

883245
type: SpeciesReference
stoichiometry: 1.0
species: 865375

883233
type: SpeciesReference
stoichiometry: 1.0
species: 867228

883220
type: SpeciesReference
stoichiometry: 1.0
species: 865412

883329
type: LocalParameter
value: 500.0

883317
type: LocalParameter
value: 0.0

883305
type: LocalParameter
value: 1000.0

883293
type: LocalParameter
value: 0.0

883257
type: SpeciesReference
stoichiometry: 1.0
species: 865883

883269
type: SpeciesReference
stoichiometry: 1.0
species: 867216

866488
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: eicosadienoate (C20:2, n-9)

864308
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864005
name: Fe2+

893265
type: Reaction
notes: GENE_ASSOCIATION: (NM_001122633.1 or NM_001875.2 or NM_001122634.1) GENE_LIST: NM_001122633.1 NM_001122634.1 NM_001875.2 SUBSYSTEM: Glutamate Metabolism
product: 893362
reactant: 893278
reactant: 893314
reversible: false
reactant: 893290
reactant: 893302
fast: false
product: 893326
name: carbamoyl-phosphate synthase (ammonia)
product: 893350
kinetic law: 893374
product: 893338

893362
type: SpeciesReference
stoichiometry: 1.0
species: 870803

893278
type: SpeciesReference
stoichiometry: 2.0
species: 869509

893314
type: SpeciesReference
stoichiometry: 1.0
species: 870500

893290
type: SpeciesReference
stoichiometry: 1.0
species: 869631

893302
type: SpeciesReference
stoichiometry: 1.0
species: 870152

893326
type: SpeciesReference
stoichiometry: 2.0
species: 869436

893350
type: SpeciesReference
stoichiometry: 3.0
species: 870140

893422
type: LocalParameter
value: 500.0

893410
type: LocalParameter
value: 0.0

893398
type: LocalParameter
value: 1000.0

893386
type: LocalParameter
value: 0.0

893338
type: SpeciesReference
stoichiometry: 1.0
species: 869547

950224
type: Reaction
kinetic law: 950260
product: 950248
reactant: 950236
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: NH3 mitochondrial transport

950309
type: LocalParameter
value: 0.0

950297
type: LocalParameter
value: 0.0

950285
type: LocalParameter
value: 1000.0

950273
type: LocalParameter
value: -1000.0

950248
type: SpeciesReference
stoichiometry: 1.0
species: 870500

950236
type: SpeciesReference
stoichiometry: 1.0
species: 867842

868842
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 863957
name: Thiosulfate

875232
type: Reaction
kinetic law: 875268
product: 875256
reactant: 875244
fast: false
reversible: true
name: eicosatrienoate (C20:3, n-6) exchange

875317
type: LocalParameter
value: 500.0

875305
type: LocalParameter
value: 0.0

875293
type: LocalParameter
value: 1000.0

875281
type: LocalParameter
value: 0.0

875256
type: SpeciesReference
stoichiometry: 1.0
species: 872230

872230
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 864017
name: ecstea6_b

875244
type: SpeciesReference
stoichiometry: 1.0
species: 864248