MODEL1111070000
type: SBMLModel
reaction: 822466
species: 767228
reaction: 835386
reaction: 785358
species: 771372
reaction: 805708
species: 770309
species: 768009
species: 770117
reaction: 835929
species: 769815
reaction: 808525
species: 770429
species: 767215
reaction: 776749
reaction: 847703
species: 772177
species: 766434
reaction: 840183
reaction: 787271
species: 766300
species: 768837
species: 768397
reaction: 802924
species: 772044
species: 767670
reaction: 843361
reaction: 818637
reaction: 777040
reaction: 831899
species: 765901
reaction: 855651
reaction: 773169
species: 771082
reaction: 780283
reaction: 854594
reaction: 787138
reaction: 773459
species: 770249
reaction: 844811
reaction: 815679
species: 768058
reaction: 777522
reaction: 788092
reaction: 774619
species: 772226
species: 768178
species: 769367
reaction: 830623
species: 771180
species: 766871
reaction: 810115
species: 769234
species: 765599
reaction: 849439
reaction: 806303
reaction: 792824
reaction: 837708
reaction: 797429
species: 768409
reaction: 778199
reaction: 850913
species: 765333
reaction: 845719
reaction: 810550
species: 770817
reaction: 856128
species: 769790
species: 766131
species: 767960
species: 771396
reaction: 824180
reaction: 807803
reaction: 785612
species: 766083
reaction: 815486
reaction: 846216
reaction: 774135
reaction: 812857

822466
type: Reaction
kinetic law: 822514
product: 822502
reactant: 822490
reactant: 822478
notes: GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citrate Cycle (TCA)
fast: false
reversible: true
name: fumarase

822563
type: LocalParameter
value: 0.0

822551
type: LocalParameter
value: 0.0

822538
type: LocalParameter
value: 1000.0

822526
type: LocalParameter
value: -1000.0

822502
type: SpeciesReference
stoichiometry: 1.0
species: 768142

768142
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Malate

765045
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Cytoplasm

822490
type: SpeciesReference
stoichiometry: 1.0
species: 767779

767779
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: H2O

822478
type: SpeciesReference
stoichiometry: 1.0
species: 767537

767537
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Fumarate

767228
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosadienoyl carnitine (C20:2Crn, n-6)

835386
type: Reaction
product: 835459
name: methylcrotonoyl-CoA carboxylase, mitochondrial
product: 835471
reversible: false
reactant: 835398
reactant: 835410
kinetic law: 835483
reactant: 835422
fast: false
notes: GENE_ASSOCIATION: (NM_020166.2 and NM_022132.3) GENE_LIST: NM_020166.2 NM_022132.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 835434
product: 835446

835459
type: SpeciesReference
stoichiometry: 1.0
species: 770333

770333
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: H+

765057
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Mitochondrion

835471
type: SpeciesReference
stoichiometry: 1.0
species: 770985

770985
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Phosphate

835398
type: SpeciesReference
stoichiometry: 1.0
species: 769549

769549
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 3-Methylbut-2-enoyl-CoA

835410
type: SpeciesReference
stoichiometry: 1.0
species: 769730

769730
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: ATP

835531
type: LocalParameter
value: 500.0

835519
type: LocalParameter
value: 0.0

835507
type: LocalParameter
value: 1000.0

835495
type: LocalParameter
value: 0.0

835422
type: SpeciesReference
stoichiometry: 1.0
species: 770369

770369
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Bicarbonate

835434
type: SpeciesReference
stoichiometry: 1.0
species: 769561

769561
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 3-Methylglutaconyl-CoA

835446
type: SpeciesReference
stoichiometry: 1.0
species: 769681

769681
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: ADP

785358
type: Reaction
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_007231.1 or NM_018976.3 or NM_001077484.1 or NM_030674.2) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
reactant: 785370
product: 785406
reactant: 785382
reversible: true
product: 785394
fast: false
name: L-asparagine transport in via sodium symport, blood
kinetic law: 785418

785370
type: SpeciesReference
stoichiometry: 1.0
species: 765153

765153
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Asparagine

765093
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Blood

785406
type: SpeciesReference
stoichiometry: 1.0
species: 768286

768286
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sodium

785382
type: SpeciesReference
stoichiometry: 1.0
species: 765575

765575
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Sodium

785394
type: SpeciesReference
stoichiometry: 1.0
species: 766374

766374
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Asparagine

785466
type: LocalParameter
value: 0.0

785454
type: LocalParameter
value: 0.0

785442
type: LocalParameter
value: 1000.0

785430
type: LocalParameter
value: -1000.0

771372
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 7-Dehydrodesmosterol

765069
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Endoplasmic_reticulum

805708
type: Reaction
kinetic law: 805744
product: 805732
reactant: 805720
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: dimethylallyl diphosphate transport, peroxisome

805792
type: LocalParameter
value: 0.0

805780
type: LocalParameter
value: 0.0

805768
type: LocalParameter
value: 1000.0

805756
type: LocalParameter
value: -1000.0

805732
type: SpeciesReference
stoichiometry: 1.0
species: 766944

766944
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Dimethylallyl diphosphate

805720
type: SpeciesReference
stoichiometry: 1.0
species: 771684

771684
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Dimethylallyl diphosphate

765081
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Peroxisome

770309
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: sn-Glycerol 3-phosphate

768009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Hexanoate

770117
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosatrienoyl carnitine (C20:3Crn, n-6)

835929
type: Reaction
product: 835977
reversible: false
fast: false
kinetic law: 836001
reactant: 835941
product: 835989
name: malic enzyme (NAD), mitochondrial
product: 835965
reactant: 835953
notes: GENE_ASSOCIATION: NM_002396.3 GENE_LIST: NM_002396.3 SUBSYSTEM: Pyruvate Metabolism

835977
type: SpeciesReference
stoichiometry: 1.0
species: 770634

770634
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Nicotinamide adenine dinucleotide - reduced

836049
type: LocalParameter
value: 500.0

836037
type: LocalParameter
value: 0.0

836025
type: LocalParameter
value: 1000.0

836013
type: LocalParameter
value: 0.0

835941
type: SpeciesReference
stoichiometry: 1.0
species: 770538

770538
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Malate

835989
type: SpeciesReference
stoichiometry: 1.0
species: 771070

771070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Pyruvate

835965
type: SpeciesReference
stoichiometry: 1.0
species: 769839

769839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CO2

835953
type: SpeciesReference
stoichiometry: 1.0
species: 770622

770622
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Nicotinamide adenine dinucleotide

769815
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: cardiolipin, adipocyte

808525
type: Reaction
reactant: 808537
reactant: 808549
product: 808597
notes: GENE_ASSOCIATION: (NM_022977.1 or NM_001995.2 or NM_004457.3 or NM_203380.1 or NM_203372.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1 or NM_015256.2 or NM_004458.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
kinetic law: 808609
reversible: true
product: 808573
reactant: 808561
fast: false
product: 808585
name: fatty-acid--CoA ligase (octadecanoate)

808537
type: SpeciesReference
stoichiometry: 1.0
species: 766398

766398
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ATP

808549
type: SpeciesReference
stoichiometry: 1.0
species: 766616

766616
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Coenzyme A

808597
type: SpeciesReference
stoichiometry: 1.0
species: 769101

769101
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Stearyl-CoA (n-C18:0CoA)

808657
type: LocalParameter
value: 0.0

808645
type: LocalParameter
value: 0.0

808633
type: LocalParameter
value: 1000.0

808621
type: LocalParameter
value: -1000.0

808573
type: SpeciesReference
stoichiometry: 1.0
species: 766338

766338
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: AMP

808561
type: SpeciesReference
stoichiometry: 1.0
species: 768397

768397
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecanoate (n-C18:0)

808585
type: SpeciesReference
stoichiometry: 1.0
species: 768885

768885
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Diphosphate

770429
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-3-Hydroxyisobutyryl-CoA

767215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosadienoyl-CoA (C20:2CoA, n-6)

776749
type: Reaction
kinetic law: 776785
product: 776773
reactant: 776761
fast: false
reversible: true
name: L-Methionine exchange

776833
type: LocalParameter
value: -5.16871499999995E-5

776821
type: LocalParameter
value: 0.0

776809
type: LocalParameter
value: 0.0

776797
type: LocalParameter
value: -1.03374299999999E-4

776773
type: SpeciesReference
stoichiometry: 1.0
species: 772274

772274
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: met_L_b

765105
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Extrasystem

776761
type: SpeciesReference
stoichiometry: 1.0
species: 765563

765563
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Methionine

847703
type: Reaction
product: 847739
product: 847751
product: 847763
reversible: false
notes: GENE_ASSOCIATION: (NM_004563.2 or NM_001018073.1) GENE_LIST: NM_001018073.1 NM_004563.2 SUBSYSTEM: Pyruvate Metabolism
reactant: 847715
reactant: 847727
name: Phosphoenolpyruvate carboxykinase (GTP), mitochondrial
fast: false
kinetic law: 847775

847739
type: SpeciesReference
stoichiometry: 1.0
species: 769839

847751
type: SpeciesReference
stoichiometry: 1.0
species: 770237

770237
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: GDP

847763
type: SpeciesReference
stoichiometry: 1.0
species: 770949

770949
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Phosphoenolpyruvate

847715
type: SpeciesReference
stoichiometry: 1.0
species: 770321

770321
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: GTP

847727
type: SpeciesReference
stoichiometry: 1.0
species: 770719

770719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Oxaloacetate

847823
type: LocalParameter
value: 500.0

847811
type: LocalParameter
value: 0.0

847799
type: LocalParameter
value: 1000.0

847787
type: LocalParameter
value: 0.0

772177
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: hdcea9_b

766434
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N-Carbamoyl-L-aspartate

840183
type: Reaction
reactant: 840207
product: 840219
reversible: true
kinetic law: 840244
product: 840231
name: nucleoside-diphosphate kinase (ATP:CDP), mitochondrial
notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Nucleotide Metabolism
reactant: 840195
fast: false

840207
type: SpeciesReference
stoichiometry: 1.0
species: 769766

769766
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CDP

840219
type: SpeciesReference
stoichiometry: 1.0
species: 769681

840292
type: LocalParameter
value: 0.0

840280
type: LocalParameter
value: 0.0

840268
type: LocalParameter
value: 1000.0

840256
type: LocalParameter
value: -1000.0

840231
type: SpeciesReference
stoichiometry: 1.0
species: 769875

769875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CTP

840195
type: SpeciesReference
stoichiometry: 1.0
species: 769730

787271
type: Reaction
product: 787334
notes: GENE_ASSOCIATION: (NM_016371.2 or NM_016142.1 or NM_002153.1 or NM_003725.2) GENE_LIST: NM_002153.1 NM_003725.2 NM_016142.1 NM_016371.2 SUBSYSTEM: Cholesterol Biosynthesis
name: C-3 sterol keto reductase (zymosterol), endoplasmic reticulum
reactant: 787310
reversible: false
fast: false
product: 787322
kinetic law: 787347
reactant: 787284
reactant: 787297

787334
type: SpeciesReference
stoichiometry: 1.0
species: 771600

771600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Zymosterol

787310
type: SpeciesReference
stoichiometry: 1.0
species: 771588

771588
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: zymosterone

787322
type: SpeciesReference
stoichiometry: 1.0
species: 771516

771516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Nicotinamide adenine dinucleotide phosphate

787396
type: LocalParameter
value: 500.0

787383
type: LocalParameter
value: 0.0

787371
type: LocalParameter
value: 1000.0

787359
type: LocalParameter
value: 0.0

787284
type: SpeciesReference
stoichiometry: 1.0
species: 771444

771444
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: H+

787297
type: SpeciesReference
stoichiometry: 1.0
species: 771528

771528
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Nicotinamide adenine dinucleotide phosphate - reduced

766300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 2-Oxoglutarate

768837
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Palmitoylcarnitine (C16:0Crn)

802924
type: Reaction
reactant: 802936
reactant: 802948
product: 803008
product: 802996
reactant: 802960
fast: false
reversible: false
reactant: 802972
product: 802984
name: Palmitoyl-CoA desaturase (n-C17:0CoA -> C17:1CoA, n-8)
kinetic law: 803020
notes: GENE_ASSOCIATION: (NM_005063.4 or NM_024906.1 or NM_001037582.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation

802936
type: SpeciesReference
stoichiometry: 1.0
species: 767767

767767
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: H+

802948
type: SpeciesReference
stoichiometry: 1.0
species: 767985

767985
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: heptadecanoyl CoA (C17:0CoA)

803008
type: SpeciesReference
stoichiometry: 1.0
species: 768323

768323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Nicotinamide adenine dinucleotide phosphate

802996
type: SpeciesReference
stoichiometry: 1.0
species: 767997

767997
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: heptadecenoyl CoA (C17:1CoA, n-8)

802960
type: SpeciesReference
stoichiometry: 1.0
species: 768335

768335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Nicotinamide adenine dinucleotide phosphate - reduced

802972
type: SpeciesReference
stoichiometry: 1.0
species: 768359

768359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: O2

802984
type: SpeciesReference
stoichiometry: 2.0
species: 767779

803068
type: LocalParameter
value: 500.0

803056
type: LocalParameter
value: 0.0

803044
type: LocalParameter
value: 1000.0

803032
type: LocalParameter
value: 0.0

772044
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: fe2_b

767670
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Glycerol

843361
type: Reaction
reactant: 843374
kinetic law: 843435
reactant: 843397
fast: false
notes: GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Proline Metabolism
product: 843423
reactant: 843385
product: 843410
reversible: false
name: pyrroline-5-carboxylate reductase

843374
type: SpeciesReference
stoichiometry: 1.0
species: 765901

765901
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 1-Pyrroline-5-carboxylate

843483
type: LocalParameter
value: 500.0

843471
type: LocalParameter
value: 0.0

843459
type: LocalParameter
value: 1000.0

843447
type: LocalParameter
value: 0.0

843397
type: SpeciesReference
stoichiometry: 1.0
species: 768310

768310
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Nicotinamide adenine dinucleotide - reduced

843423
type: SpeciesReference
stoichiometry: 1.0
species: 768921

768921
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Proline

843385
type: SpeciesReference
stoichiometry: 2.0
species: 767767

843410
type: SpeciesReference
stoichiometry: 1.0
species: 768298

768298
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Nicotinamide adenine dinucleotide

818637
type: Reaction
name: fatty acid synthase (n-C12:0)
reactant: 818685
fast: false
kinetic law: 818757
reversible: false
reactant: 818661
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 818673
product: 818745
product: 818733
reactant: 818649
product: 818697
product: 818709
product: 818721

818685
type: SpeciesReference
stoichiometry: 2.0
species: 768335

818805
type: LocalParameter
value: 500.0

818793
type: LocalParameter
value: 0.0

818781
type: LocalParameter
value: 1000.0

818769
type: LocalParameter
value: 0.0

818661
type: SpeciesReference
stoichiometry: 3.0
species: 767767

818673
type: SpeciesReference
stoichiometry: 1.0
species: 768154

768154
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Malonyl-CoA

818745
type: SpeciesReference
stoichiometry: 2.0
species: 768323

818733
type: SpeciesReference
stoichiometry: 1.0
species: 767779

818649
type: SpeciesReference
stoichiometry: 1.0
species: 766700

766700
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Decanoate

818697
type: SpeciesReference
stoichiometry: 1.0
species: 766604

766604
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CO2

818709
type: SpeciesReference
stoichiometry: 1.0
species: 766616

818721
type: SpeciesReference
stoichiometry: 1.0
species: 766833

766833
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dodecanoate (C12:0)

777040
type: Reaction
kinetic law: 777076
product: 777064
reactant: 777052
fast: false
reversible: true
name: O2 exchange

777125
type: LocalParameter
value: 0.0

777113
type: LocalParameter
value: 0.0

777100
type: LocalParameter
value: 1000.0

777088
type: LocalParameter
value: -1000.0

777064
type: SpeciesReference
stoichiometry: 1.0
species: 772310

772310
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: o2_b

777052
type: SpeciesReference
stoichiometry: 1.0
species: 765599

765599
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: O2

831899
type: Reaction
kinetic law: 831947
product: 831935
reactant: 831923
reactant: 831911
notes: SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: true
name: S-(hydroxymethyl)glutathione synthase

831996
type: LocalParameter
value: 0.0

831983
type: LocalParameter
value: 0.0

831971
type: LocalParameter
value: 1000.0

831959
type: LocalParameter
value: -1000.0

831935
type: SpeciesReference
stoichiometry: 1.0
species: 767948

767948
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: S-(Hydroxymethyl)glutathione

831923
type: SpeciesReference
stoichiometry: 1.0
species: 767743

767743
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Reduced glutathione

831911
type: SpeciesReference
stoichiometry: 1.0
species: 767428

767428
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Formaldehyde

855651
type: Reaction
kinetic law: 855687
product: 855675
reactant: 855663
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_012244.2 or NM_018593.3 or NM_182728.1) GENE_LIST: NM_003486.5 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tyrosine transport

855735
type: LocalParameter
value: 0.0

855723
type: LocalParameter
value: 0.0

855711
type: LocalParameter
value: 1000.0

855699
type: LocalParameter
value: -1000.0

855675
type: SpeciesReference
stoichiometry: 1.0
species: 769318

769318
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Tyrosine

855663
type: SpeciesReference
stoichiometry: 1.0
species: 765828

765828
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Tyrosine

773169
type: Reaction
kinetic law: 773205
product: 773193
reactant: 773181
fast: false
reversible: true
name: Acetate exchange

773253
type: LocalParameter
value: 500.0

773241
type: LocalParameter
value: 0.0

773229
type: LocalParameter
value: 1000.0

773217
type: LocalParameter
value: 0.0

773193
type: SpeciesReference
stoichiometry: 1.0
species: 771828

771828
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ac_b

773181
type: SpeciesReference
stoichiometry: 1.0
species: 765117

765117
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Acetate

771082
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Ubiquinol-10

780283
type: Reaction
fast: false
reactant: 780307
product: 780319
product: 780331
reactant: 780295
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reversible: true
kinetic law: 780343
name: acyl-CoA dehydrogenase, mitochondrial

780307
type: SpeciesReference
stoichiometry: 1.0
species: 770477

770477
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Isobutyryl-CoA

780319
type: SpeciesReference
stoichiometry: 1.0
species: 769500

769500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 2-Methylprop-2-enoyl-CoA

780331
type: SpeciesReference
stoichiometry: 1.0
species: 770165

770165
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: FADH2

780295
type: SpeciesReference
stoichiometry: 1.0
species: 770153

770153
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: FAD

780392
type: LocalParameter
value: 0.0

780379
type: LocalParameter
value: 0.0

780367
type: LocalParameter
value: 1000.0

780355
type: LocalParameter
value: -1000.0

854594
type: Reaction
kinetic law: 854630
product: 854618
reactant: 854606
notes: GENE_ASSOCIATION: NM_000365.4 GENE_LIST: NM_000365.4 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: triose-phosphate isomerase

854680
type: LocalParameter
value: 0.0

854668
type: LocalParameter
value: 0.0

854656
type: LocalParameter
value: 1000.0

854643
type: LocalParameter
value: -1000.0

854618
type: SpeciesReference
stoichiometry: 1.0
species: 767561

767561
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Glyceraldehyde 3-phosphate

854606
type: SpeciesReference
stoichiometry: 1.0
species: 766895

766895
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Dihydroxyacetone phosphate

787138
type: Reaction
kinetic law: 787211
reversible: false
product: 787187
product: 787199
reactant: 787163
fast: false
product: 787175
reactant: 787150
notes: GENE_ASSOCIATION: NM_015922.1 GENE_LIST: NM_015922.1 SUBSYSTEM: Cholesterol Biosynthesis
name: C-3 sterol dehydrogenase NADPH, (4-methylzymosterol)

787259
type: LocalParameter
value: 500.0

787247
type: LocalParameter
value: 0.0

787235
type: LocalParameter
value: 1000.0

787223
type: LocalParameter
value: 0.0

787187
type: SpeciesReference
stoichiometry: 1.0
species: 771360

771360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: CO2

787199
type: SpeciesReference
stoichiometry: 1.0
species: 771528

787163
type: SpeciesReference
stoichiometry: 1.0
species: 771516

787175
type: SpeciesReference
stoichiometry: 1.0
species: 771276

771276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 4-Methylzymosterol intermediate 2

787150
type: SpeciesReference
stoichiometry: 1.0
species: 771264

771264
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 4-Methylzymosterol intermediate 1

773459
type: Reaction
kinetic law: 773495
product: 773483
reactant: 773471
fast: false
reversible: true
name: L-Asparagine exchange

773543
type: LocalParameter
value: 500.0

773531
type: LocalParameter
value: 0.0

773519
type: LocalParameter
value: 1000.0

773507
type: LocalParameter
value: 0.0

773483
type: SpeciesReference
stoichiometry: 1.0
species: 771864

771864
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: asn_L_b

773471
type: SpeciesReference
stoichiometry: 1.0
species: 765153

770249
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Glutamine

844811
type: Reaction
kinetic law: 844883
reversible: false
reactant: 844835
notes: GENE_ASSOCIATION: NM_002631.2 GENE_LIST: NM_002631.2 SUBSYSTEM: Pentose Phosphate Pathway
product: 844847
product: 844859
product: 844871
fast: false
reactant: 844823
name: phosphogluconate dehydrogenase

844931
type: LocalParameter
value: 500.0

844919
type: LocalParameter
value: 0.0

844907
type: LocalParameter
value: 1000.0

844895
type: LocalParameter
value: 0.0

844835
type: SpeciesReference
stoichiometry: 1.0
species: 768323

844847
type: SpeciesReference
stoichiometry: 1.0
species: 766604

844859
type: SpeciesReference
stoichiometry: 1.0
species: 768335

844871
type: SpeciesReference
stoichiometry: 1.0
species: 769005

769005
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Ribulose 5-phosphate

844823
type: SpeciesReference
stoichiometry: 1.0
species: 766095

766095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 6-Phospho-D-gluconate

815679
type: Reaction
product: 815775
reversible: false
product: 815787
reactant: 815739
kinetic law: 815799
reactant: 815727
name: Beta oxidation of fatty acid
product: 815751
reactant: 815715
product: 815763
reactant: 815703
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_014049.3 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_0010... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_0010... NM_001033859.1 NM_001037811.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 815691
fast: false

815775
type: SpeciesReference
stoichiometry: 9.0
species: 770333

815787
type: SpeciesReference
stoichiometry: 9.0
species: 770634

815739
type: SpeciesReference
stoichiometry: 9.0
species: 770622

815848
type: LocalParameter
value: 500.0

815836
type: LocalParameter
value: 0.0

815824
type: LocalParameter
value: 1000.0

815811
type: LocalParameter
value: 0.0

815727
type: SpeciesReference
stoichiometry: 9.0
species: 770345

770345
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: H2O

815751
type: SpeciesReference
stoichiometry: 10.0
species: 769657

769657
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Acetyl-CoA

815715
type: SpeciesReference
stoichiometry: 8.0
species: 770153

815763
type: SpeciesReference
stoichiometry: 8.0
species: 770165

815703
type: SpeciesReference
stoichiometry: 1.0
species: 770057

770057
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosenoyl-CoA (C20:1CoA, n-11)

815691
type: SpeciesReference
stoichiometry: 9.0
species: 769851

769851
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Coenzyme A

768058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: IMP

777522
type: Reaction
kinetic law: 777558
product: 777546
reactant: 777534
fast: false
reversible: true
name: octadecatrienoate (C18:3, n-3) exchange

777606
type: LocalParameter
value: -1.8070695E-4

777594
type: LocalParameter
value: 0.0

777582
type: LocalParameter
value: 0.0

777570
type: LocalParameter
value: -3.614139E-4

777546
type: SpeciesReference
stoichiometry: 1.0
species: 772370

772370
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocdctra3_b

777534
type: SpeciesReference
stoichiometry: 1.0
species: 765660

765660
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecatrienoate (C18:3, n-3)

788092
type: Reaction
kinetic law: 788141
product: 788129
product: 788116
reactant: 788104
notes: GENE_ASSOCIATION: NM_001752.2 GENE_LIST: NM_001752.2 SUBSYSTEM: Other
fast: false
reversible: false
name: catalase

788189
type: LocalParameter
value: 500.0

788177
type: LocalParameter
value: 0.0

788165
type: LocalParameter
value: 1000.0

788153
type: LocalParameter
value: 0.0

788129
type: SpeciesReference
stoichiometry: 1.0
species: 771780

771780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: O2

788116
type: SpeciesReference
stoichiometry: 2.0
species: 771732

771732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: H2O

788104
type: SpeciesReference
stoichiometry: 2.0
species: 771744

771744
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Hydrogen peroxide

774619
type: Reaction
kinetic law: 774656
product: 774644
reactant: 774631
fast: false
reversible: true
name: eicosatrienoate (C20:3, n-6) exchange

774705
type: LocalParameter
value: 500.0

774692
type: LocalParameter
value: 0.0

774680
type: LocalParameter
value: 1000.0

774668
type: LocalParameter
value: 0.0

774644
type: SpeciesReference
stoichiometry: 1.0
species: 772008

772008
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ecstea6_b

774631
type: SpeciesReference
stoichiometry: 1.0
species: 765297

765297
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: eicosatrienoate (C20:3, n-6)

772226
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ile_L_b

768178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Methionine

769367
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Uridine

830623
type: Reaction
product: 830659
product: 830671
name: homogentisate 1,2-dioxygenase
reactant: 830647
notes: GENE_ASSOCIATION: NM_000187.2 GENE_LIST: NM_000187.2 SUBSYSTEM: Tyrosine metabolism
reactant: 830635
reversible: false
fast: false
kinetic law: 830683

830659
type: SpeciesReference
stoichiometry: 1.0
species: 766022

766022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 4-Maleylacetoacetate

830671
type: SpeciesReference
stoichiometry: 1.0
species: 767767

830647
type: SpeciesReference
stoichiometry: 1.0
species: 768359

830635
type: SpeciesReference
stoichiometry: 1.0
species: 767912

767912
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Homogentisate

830731
type: LocalParameter
value: 500.0

830719
type: LocalParameter
value: 0.0

830707
type: LocalParameter
value: 1000.0

830695
type: LocalParameter
value: 0.0

771180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: tetradecenoyl carnitine (C14:1Crn, n-5)

766871
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dGDP

810115
type: Reaction
reactant: 810152
reactant: 810140
product: 810188
product: 810164
fast: false
reversible: true
kinetic law: 810200
name: fatty-acid--CoA ligase (eicosatetraenoate, C20:4 n-6)
product: 810176
reactant: 810127
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_001009185.1 or NM_016234.3 or NM_203372.1 or NM_203379.1 or NM_203380.1 or NM_015256.2 or NM_004458.1 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis

810152
type: SpeciesReference
stoichiometry: 1.0
species: 767202

767202
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatetraenoate (C20:4, n-6)

810140
type: SpeciesReference
stoichiometry: 1.0
species: 766616

810188
type: SpeciesReference
stoichiometry: 1.0
species: 768885

810164
type: SpeciesReference
stoichiometry: 1.0
species: 766338

810248
type: LocalParameter
value: 0.0

810236
type: LocalParameter
value: 0.0

810224
type: LocalParameter
value: 1000.0

810212
type: LocalParameter
value: -1000.0

810176
type: SpeciesReference
stoichiometry: 1.0
species: 767355

767355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)

810127
type: SpeciesReference
stoichiometry: 1.0
species: 766398

769234
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Oxidized thioredoxin

849439
type: Reaction
kinetic law: 849501
product: 849477
fast: false
notes: GENE_ASSOCIATION: NM_004577.3 GENE_LIST: NM_004577.3 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reactant: 849452
reactant: 849464
name: phosphoserine phosphatase (L-serine)
product: 849489
reversible: false

849552
type: LocalParameter
value: 500.0

849539
type: LocalParameter
value: 0.0

849527
type: LocalParameter
value: 1000.0

849514
type: LocalParameter
value: 0.0

849477
type: SpeciesReference
stoichiometry: 1.0
species: 768800

768800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphate

849452
type: SpeciesReference
stoichiometry: 1.0
species: 767779

849464
type: SpeciesReference
stoichiometry: 1.0
species: 768957

768957
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: O-Phospho-L-serine

849489
type: SpeciesReference
stoichiometry: 1.0
species: 769041

769041
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Serine

806303
type: Reaction
kinetic law: 806351
product: 806339
reactant: 806327
reactant: 806315
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: enoyl-CoA hydratase, mitochondrial

806400
type: LocalParameter
value: 0.0

806388
type: LocalParameter
value: 0.0

806375
type: LocalParameter
value: 1000.0

806363
type: LocalParameter
value: -1000.0

806339
type: SpeciesReference
stoichiometry: 1.0
species: 770429

806327
type: SpeciesReference
stoichiometry: 1.0
species: 770345

806315
type: SpeciesReference
stoichiometry: 1.0
species: 769500

792824
type: Reaction
kinetic law: 792885
reactant: 792848
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 792873
product: 792861
fast: false
reversible: true
reactant: 792836
name: carnitine eicosadienoyltransferase (C20:2Crn, n6), mitochondrial

792933
type: LocalParameter
value: 0.0

792921
type: LocalParameter
value: 0.0

792909
type: LocalParameter
value: 1000.0

792897
type: LocalParameter
value: -1000.0

792848
type: SpeciesReference
stoichiometry: 1.0
species: 770032

770032
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosadienoyl-CoA (C20:2CoA, n-6)

792873
type: SpeciesReference
stoichiometry: 1.0
species: 770044

770044
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosadienoyl carnitine (C20:2Crn, n-6)

792861
type: SpeciesReference
stoichiometry: 1.0
species: 769851

792836
type: SpeciesReference
stoichiometry: 1.0
species: 769863

769863
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Carnitine

837708
type: Reaction
kinetic law: 837744
product: 837732
reactant: 837720
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: Methylmalonate transport, mitochondrial

837792
type: LocalParameter
value: 0.0

837780
type: LocalParameter
value: 0.0

837768
type: LocalParameter
value: 1000.0

837756
type: LocalParameter
value: -1000.0

837732
type: SpeciesReference
stoichiometry: 1.0
species: 768250

768250
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Methylmalonate

837720
type: SpeciesReference
stoichiometry: 1.0
species: 770574

770574
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Methylmalonate

797429
type: Reaction
reactant: 797441
notes: GENE_ASSOCIATION: (NM_152359.1 or NM_152245.1 or NM_001031847.1 or NM_152247.1 or NM_001876.2 or NM_004377.2 or NM_152246.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reactant: 797453
product: 797466
kinetic law: 797490
name: carnitine pentadecanoyltransferase (C15:0Crn)
reversible: true
product: 797478

797441
type: SpeciesReference
stoichiometry: 1.0
species: 766628

766628
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Carnitine

797453
type: SpeciesReference
stoichiometry: 1.0
species: 768739

768739
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: pentadecanoyl-CoA (C15:0CoA)

797466
type: SpeciesReference
stoichiometry: 1.0
species: 766616

797538
type: LocalParameter
value: 0.0

797526
type: LocalParameter
value: 0.0

797514
type: LocalParameter
value: 1000.0

797502
type: LocalParameter
value: -1000.0

797478
type: SpeciesReference
stoichiometry: 1.0
species: 768751

768751
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: pentadecanoylcarnitine (C15:0Crn)

768409
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoate (C18:1, n-5)

778199
type: Reaction
kinetic law: 778235
product: 778223
reactant: 778211
fast: false
reversible: true
name: pentadecanoate (C15:0) exchange

778283
type: LocalParameter
value: 500.0

778271
type: LocalParameter
value: 0.0

778259
type: LocalParameter
value: 1000.0

778247
type: LocalParameter
value: 0.0

778223
type: SpeciesReference
stoichiometry: 1.0
species: 772455

772455
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ptdca_b

778211
type: SpeciesReference
stoichiometry: 1.0
species: 765744

765744
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: pentadecanoate (C15:0)

850913
type: Reaction
kinetic law: 850949
product: 850937
reactant: 850925
notes: GENE_ASSOCIATION: NM_144563.2 GENE_LIST: NM_144563.2 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
reversible: true
name: ribose-5-phosphate isomerase

850998
type: LocalParameter
value: 0.0

850986
type: LocalParameter
value: 0.0

850974
type: LocalParameter
value: 1000.0

850962
type: LocalParameter
value: -1000.0

850937
type: SpeciesReference
stoichiometry: 1.0
species: 769005

850925
type: SpeciesReference
stoichiometry: 1.0
species: 768993

768993
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: alpha-D-Ribose 5-phosphate

765333
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Fe2+

845719
type: Reaction
reactant: 845731
reactant: 845755
reactant: 845743
product: 845779
product: 845791
notes: GENE_ASSOCIATION: NM_000277.1 GENE_LIST: NM_000277.1 SUBSYSTEM: Phenylalanine, Tyrosine, and Tryptophan Biosynthesis
reversible: false
name: phenylalanine 4-monooxygenase
product: 845767
kinetic law: 845803
fast: false

845731
type: SpeciesReference
stoichiometry: 1.0
species: 768359

845755
type: SpeciesReference
stoichiometry: 1.0
species: 769186

769186
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Tetrahydrobiopterin

845743
type: SpeciesReference
stoichiometry: 1.0
species: 768788

768788
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Phenylalanine

845779
type: SpeciesReference
stoichiometry: 1.0
species: 767779

845791
type: SpeciesReference
stoichiometry: 1.0
species: 769318

845767
type: SpeciesReference
stoichiometry: 1.0
species: 766908

766908
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 6,7-Dihydrobiopterin

845852
type: LocalParameter
value: 500.0

845840
type: LocalParameter
value: 0.0

845827
type: LocalParameter
value: 1000.0

845815
type: LocalParameter
value: 0.0

810550
type: Reaction
kinetic law: 810634
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203379.1 or NM_001009185.1 or NM_203372.1 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
product: 810598
product: 810622
reactant: 810562
reversible: true
reactant: 810586
name: fatty-acid--CoA ligase (ocosatetraenoate, C22:4 n-6)
product: 810610
reactant: 810574

810682
type: LocalParameter
value: 0.0

810670
type: LocalParameter
value: 0.0

810658
type: LocalParameter
value: 1000.0

810646
type: LocalParameter
value: -1000.0

810598
type: SpeciesReference
stoichiometry: 1.0
species: 766338

810622
type: SpeciesReference
stoichiometry: 1.0
species: 768885

810562
type: SpeciesReference
stoichiometry: 1.0
species: 766398

810586
type: SpeciesReference
stoichiometry: 1.0
species: 768495

768495
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ocosatetraenoate (C22:4, n-6)

810610
type: SpeciesReference
stoichiometry: 1.0
species: 768666

768666
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ocosatetraenoyl-CoA (C22:4CoA, n-6)

810574
type: SpeciesReference
stoichiometry: 1.0
species: 766616

770817
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl-CoA (C18:1CoA, n-9)

856128
type: Reaction
product: 856179
notes: GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
reactant: 856154
name: valine transaminase, mitochondrial
reversible: true
reactant: 856141
kinetic law: 856191
fast: false
product: 856167

856179
type: SpeciesReference
stoichiometry: 1.0
species: 770261

770261
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Glutamate

856154
type: SpeciesReference
stoichiometry: 1.0
species: 771228

771228
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Valine

856141
type: SpeciesReference
stoichiometry: 1.0
species: 769693

769693
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 2-Oxoglutarate

856239
type: LocalParameter
value: 0.0

856227
type: LocalParameter
value: 0.0

856215
type: LocalParameter
value: 1000.0

856203
type: LocalParameter
value: -1000.0

856167
type: SpeciesReference
stoichiometry: 1.0
species: 769573

769573
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 3-Methyl-2-oxobutanoate

769790
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Citrate

766131
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3,4-Dihydroxy-L-phenylalanine

767960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: heptadecanoate (C17:0)

771396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Formate

824180
type: Reaction
product: 824228
fast: false
product: 824252
name: glutamate aspartate carrier, cytosolic/mitochondrial
reactant: 824192
notes: GENE_ASSOCIATION: (NM_014251.2 or NM_003705.2) GENE_LIST: NM_003705.2 NM_014251.2 SUBSYSTEM: Transport, Mitochondrial
reactant: 824204
kinetic law: 824264
reversible: false
product: 824240
reactant: 824216

824228
type: SpeciesReference
stoichiometry: 1.0
species: 766386

766386
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Aspartate

824252
type: SpeciesReference
stoichiometry: 1.0
species: 770333

824192
type: SpeciesReference
stoichiometry: 1.0
species: 767633

767633
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Glutamate

824204
type: SpeciesReference
stoichiometry: 1.0
species: 767767

824312
type: LocalParameter
value: 500.0

824300
type: LocalParameter
value: 0.0

824288
type: LocalParameter
value: 1000.0

824276
type: LocalParameter
value: 0.0

824240
type: SpeciesReference
stoichiometry: 1.0
species: 770261

824216
type: SpeciesReference
stoichiometry: 1.0
species: 769718

769718
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Aspartate

807803
type: Reaction
notes: GENE_ASSOCIATION: (NM_022977.1 or NM_001995.2 or NM_004458.1 or NM_004457.3 or NM_203372.1 or NM_016234.3 or NM_001009185.1 or NM_203379.1 or NM_203380.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
product: 807851
reactant: 807815
reversible: true
product: 807875
kinetic law: 807887
name: fatty-acid--CoA ligase (hexadecanoate)
reactant: 807839
fast: false
product: 807863
reactant: 807827

807851
type: SpeciesReference
stoichiometry: 1.0
species: 766338

807815
type: SpeciesReference
stoichiometry: 1.0
species: 766398

807875
type: SpeciesReference
stoichiometry: 1.0
species: 768885

807936
type: LocalParameter
value: 0.0

807924
type: LocalParameter
value: 0.0

807912
type: LocalParameter
value: 1000.0

807900
type: LocalParameter
value: -1000.0

807839
type: SpeciesReference
stoichiometry: 1.0
species: 767827

767827
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecanoate (n-C16:0)

807863
type: SpeciesReference
stoichiometry: 1.0
species: 768825

768825
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Palmitoyl-CoA (n-C16:0CoA)

807827
type: SpeciesReference
stoichiometry: 1.0
species: 766616

785612
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Alanine and Aspartate Metabolism
product: 785648
name: aspartate transaminase
reactant: 785624
kinetic law: 785672
fast: false
reactant: 785636
product: 785660

785648
type: SpeciesReference
stoichiometry: 1.0
species: 767633

785624
type: SpeciesReference
stoichiometry: 1.0
species: 766300

785722
type: LocalParameter
value: 0.0

785710
type: LocalParameter
value: 0.0

785697
type: LocalParameter
value: 1000.0

785685
type: LocalParameter
value: -1000.0

785636
type: SpeciesReference
stoichiometry: 1.0
species: 766386

785660
type: SpeciesReference
stoichiometry: 1.0
species: 768385

768385
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Oxaloacetate

766083
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Methyltetrahydrofolate

815486
type: Reaction
product: 815570
reactant: 815510
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_014049.3 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
kinetic law: 815618
fast: false
product: 815582
reactant: 815522
name: Beta oxidation of long chain fatty acid
reactant: 815534
product: 815558
reactant: 815546
product: 815606
reactant: 815498
product: 815594
reversible: false

815570
type: SpeciesReference
stoichiometry: 1.0
species: 770165

815510
type: SpeciesReference
stoichiometry: 1.0
species: 769995

769995
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Eicosanoyl-CoA (n-C20:0CoA)

815667
type: LocalParameter
value: 500.0

815655
type: LocalParameter
value: 0.0

815643
type: LocalParameter
value: 1000.0

815630
type: LocalParameter
value: 0.0

815582
type: SpeciesReference
stoichiometry: 1.0
species: 770333

815522
type: SpeciesReference
stoichiometry: 1.0
species: 770153

815534
type: SpeciesReference
stoichiometry: 1.0
species: 770345

815558
type: SpeciesReference
stoichiometry: 1.0
species: 769657

815546
type: SpeciesReference
stoichiometry: 1.0
species: 770622

815606
type: SpeciesReference
stoichiometry: 1.0
species: 771095

771095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Stearyl-CoA (n-C18:0CoA)

815498
type: SpeciesReference
stoichiometry: 1.0
species: 769851

815594
type: SpeciesReference
stoichiometry: 1.0
species: 770634

846216
type: Reaction
kinetic law: 846276
reversible: true
notes: GENE_ASSOCIATION: (NM_005415.3 or NM_006749.3) GENE_LIST: NM_005415.3 NM_006749.3 SUBSYSTEM: Transport, Extracellular
product: 846252
reactant: 846228
fast: false
reactant: 846240
product: 846264
name: phosphate transport in/out via proton symporter

846324
type: LocalParameter
value: 0.0

846312
type: LocalParameter
value: 0.0

846300
type: LocalParameter
value: 1000.0

846288
type: LocalParameter
value: -1000.0

846252
type: SpeciesReference
stoichiometry: 1.0
species: 767767

846228
type: SpeciesReference
stoichiometry: 1.0
species: 765406

765406
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: H+

846240
type: SpeciesReference
stoichiometry: 1.0
species: 765708

765708
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Phosphate

846264
type: SpeciesReference
stoichiometry: 1.0
species: 768800

774135
type: Reaction
kinetic law: 774172
product: 774160
reactant: 774148
fast: false
reversible: true
name: docosapentaenoate (C22:5, n-3) exchange

774220
type: LocalParameter
value: 500.0

774208
type: LocalParameter
value: 0.0

774196
type: LocalParameter
value: 1000.0

774184
type: LocalParameter
value: 0.0

774160
type: SpeciesReference
stoichiometry: 1.0
species: 771948

771948
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: dcspea3_b

774148
type: SpeciesReference
stoichiometry: 1.0
species: 765237

765237
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: docosapentaenoate (C22:5, n-3)

812857
type: Reaction
reactant: 812917
reactant: 812869
reactant: 812881
reversible: false
product: 812929
fast: false
product: 812965
product: 812953
product: 812941
reactant: 812905
product: 812977
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 812893
kinetic law: 812989
name: Beta oxidation of fatty acid

812917
type: SpeciesReference
stoichiometry: 1.0
species: 770622

812869
type: SpeciesReference
stoichiometry: 1.0
species: 769851

812881
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stoichiometry: 1.0
species: 769899

769899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Dodecanoyl-CoA (n-C12:0CoA)

812929
type: SpeciesReference
stoichiometry: 1.0
species: 769657

812965
type: SpeciesReference
stoichiometry: 1.0
species: 770333

812953
type: SpeciesReference
stoichiometry: 1.0
species: 770165

812941
type: SpeciesReference
stoichiometry: 1.0
species: 769887

769887
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Decanoyl-CoA (C10:0CoA)

812905
type: SpeciesReference
stoichiometry: 1.0
species: 770345

812977
type: SpeciesReference
stoichiometry: 1.0
species: 770634

812893
type: SpeciesReference
stoichiometry: 1.0
species: 770153

813039
type: LocalParameter
value: 500.0

813027
type: LocalParameter
value: 0.0

813014
type: LocalParameter
value: 1000.0

813001
type: LocalParameter
value: 0.0

767112
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Eicosanoate (n-C20:0)

838927
type: Reaction
kinetic law: 838987
fast: false
reactant: 838951
reversible: true
product: 838975
notes: GENE_ASSOCIATION: NM_006636.3 GENE_LIST: NM_006636.3
reactant: 838939
product: 838963
name: methylenetetrahydrofolate dehydrogenase (NAD), mitochondrial

839035
type: LocalParameter
value: 0.0

839023
type: LocalParameter
value: 0.0

839011
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value: 1000.0

838999
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value: -1000.0

838951
type: SpeciesReference
stoichiometry: 1.0
species: 770622

838975
type: SpeciesReference
stoichiometry: 1.0
species: 770634

838939
type: SpeciesReference
stoichiometry: 1.0
species: 770562

770562
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 5,10-Methylenetetrahydrofolate

838963
type: SpeciesReference
stoichiometry: 1.0
species: 770550

770550
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 5,10-Methenyltetrahydrofolate

769706
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: AMP

770586
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-Methylmalonate semialdehyde

766458
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CDP

766846
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Dodecanoyl-CoA (n-C12:0CoA)

824084
type: Reaction
kinetic law: 824120
product: 824108
reactant: 824096
notes: GENE_ASSOCIATION: NM_001467.3 GENE_LIST: NM_001467.3 SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: glucose 6-phosphate endoplasmic reticular transport via diffusion

824168
type: LocalParameter
value: 0.0

824156
type: LocalParameter
value: 0.0

824144
type: LocalParameter
value: 1000.0

824132
type: LocalParameter
value: -1000.0

824108
type: SpeciesReference
stoichiometry: 1.0
species: 771420

771420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: D-Glucose 6-phosphate

824096
type: SpeciesReference
stoichiometry: 1.0
species: 767573

767573
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Glucose 6-phosphate

770453
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: heptanoyl-CoA (C7:0CoA)

766325
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: S-Adenosyl-L-methionine

770913
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: propionyl-carnitine

809681
type: Reaction
product: 809730
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_203372.1 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1 or NM_001995.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reactant: 809693
fast: false
product: 809754
product: 809742
reversible: true
reactant: 809705
kinetic law: 809766
reactant: 809718
name: fatty-acid--CoA ligase (eicosenoate, C20:1 n-9)

809730
type: SpeciesReference
stoichiometry: 1.0
species: 766338

809693
type: SpeciesReference
stoichiometry: 1.0
species: 766398

809754
type: SpeciesReference
stoichiometry: 1.0
species: 768885

809742
type: SpeciesReference
stoichiometry: 1.0
species: 767254

767254
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoyl-CoA (C20:1CoA, n-9)

809705
type: SpeciesReference
stoichiometry: 1.0
species: 766616

809814
type: LocalParameter
value: 0.0

809802
type: LocalParameter
value: 0.0

809790
type: LocalParameter
value: 1000.0

809778
type: LocalParameter
value: -1000.0

809718
type: SpeciesReference
stoichiometry: 1.0
species: 767177

767177
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoate (C20:1, n-9)

839568
type: Reaction
name: nucleoside-diphosphatase (dUDP)
kinetic law: 839640
product: 839604
notes: GENE_ASSOCIATION: (NM_001948.3 or NM_001025249.1 or NM_001025248.1) GENE_LIST: NM_001025248.1 NM_001025249.1 NM_001948.3 SUBSYSTEM: Nucleotide Metabolism
reactant: 839592
product: 839628
fast: false
product: 839616
reversible: false
reactant: 839580

839688
type: LocalParameter
value: 500.0

839676
type: LocalParameter
value: 0.0

839664
type: LocalParameter
value: 1000.0

839652
type: LocalParameter
value: 0.0

839604
type: SpeciesReference
stoichiometry: 1.0
species: 767088

767088
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dUMP

839592
type: SpeciesReference
stoichiometry: 1.0
species: 767779

839628
type: SpeciesReference
stoichiometry: 1.0
species: 768800

839616
type: SpeciesReference
stoichiometry: 1.0
species: 767767

839580
type: SpeciesReference
stoichiometry: 1.0
species: 767076

767076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dUDP

769053
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sulfite

840667
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_005793.3 or NM_013330.3 or NM_002513.2 or (NM_000269.2 and NM_001018138.1) or (NM_001018139.1 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_000269.2 and NM_002512.2) or (NM_001018138.1 and NM_198175.1) or (NM_002512.2 and NM_198175.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_197972.1) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
product: 840716
reactant: 840679
product: 840704
name: nucleoside-diphosphate kinase (ATP:dADP)
reversible: true
kinetic law: 840728
reactant: 840691

840716
type: SpeciesReference
stoichiometry: 1.0
species: 766688

766688
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dATP

840679
type: SpeciesReference
stoichiometry: 1.0
species: 766398

840704
type: SpeciesReference
stoichiometry: 1.0
species: 766240

766240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ADP

840776
type: LocalParameter
value: 0.0

840764
type: LocalParameter
value: 0.0

840752
type: LocalParameter
value: 1000.0

840740
type: LocalParameter
value: -1000.0

840691
type: SpeciesReference
stoichiometry: 1.0
species: 766676

766676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dADP

840885
type: Reaction
kinetic law: 840921
product: 840909
reactant: 840897
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: NH3 mitochondrial transport

840969
type: LocalParameter
value: 0.0

840957
type: LocalParameter
value: 0.0

840945
type: LocalParameter
value: 1000.0

840933
type: LocalParameter
value: -1000.0

840909
type: SpeciesReference
stoichiometry: 1.0
species: 770671

770671
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Ammonium

840897
type: SpeciesReference
stoichiometry: 1.0
species: 768347

768347
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Ammonium

836061
type: Reaction
kinetic law: 836135
reactant: 836086
reactant: 836073
product: 836099
product: 836123
name: malic enzyme (NADP)
reversible: true
product: 836111
fast: false
notes: GENE_ASSOCIATION: NM_002395.2 GENE_LIST: NM_002395.2 SUBSYSTEM: Pyruvate Metabolism

836183
type: LocalParameter
value: 0.0

836171
type: LocalParameter
value: 0.0

836159
type: LocalParameter
value: 1000.0

836147
type: LocalParameter
value: -1000.0

836086
type: SpeciesReference
stoichiometry: 1.0
species: 768323

836073
type: SpeciesReference
stoichiometry: 1.0
species: 768142

836099
type: SpeciesReference
stoichiometry: 1.0
species: 766604

836123
type: SpeciesReference
stoichiometry: 1.0
species: 768981

768981
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Pyruvate

836111
type: SpeciesReference
stoichiometry: 1.0
species: 768335

765913
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (S)-2-[5-Amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate

769803
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Citrulline

823060
type: Reaction
fast: false
product: 823096
notes: GENE_ASSOCIATION: NM_005276.2 GENE_LIST: NM_005276.2 SUBSYSTEM: Glycerophospholipid Metabolism
product: 823108
reversible: true
product: 823121
name: glycerol-3-phosphate dehydrogenase (NAD)
reactant: 823072
reactant: 823084
kinetic law: 823133

823096
type: SpeciesReference
stoichiometry: 1.0
species: 766895

823108
type: SpeciesReference
stoichiometry: 1.0
species: 767767

823121
type: SpeciesReference
stoichiometry: 1.0
species: 768310

823072
type: SpeciesReference
stoichiometry: 1.0
species: 767683

767683
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: sn-Glycerol 3-phosphate

823084
type: SpeciesReference
stoichiometry: 1.0
species: 768298

823182
type: LocalParameter
value: 0.0

823169
type: LocalParameter
value: 0.0

823157
type: LocalParameter
value: 1000.0

823145
type: LocalParameter
value: -1000.0

766809
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosapentaenoate (C22:5, n-3)

841886
type: Reaction
kinetic law: 841922
product: 841910
reactant: 841898
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecanoate (n-C18:0) transport in via uniport

841970
type: LocalParameter
value: 0.0

841958
type: LocalParameter
value: 0.0

841946
type: LocalParameter
value: 1000.0

841934
type: LocalParameter
value: -1000.0

841910
type: SpeciesReference
stoichiometry: 1.0
species: 765611

765611
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecanoate (n-C18:0)

841898
type: SpeciesReference
stoichiometry: 1.0
species: 768397

845864
type: Reaction
kinetic law: 845900
product: 845888
reactant: 845876
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_018593.3 or NM_003627.4 or NM_012244.2 or NM_182728.1) GENE_LIST: NM_003486.5 NM_003627.4 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-phenylalanine transport via diffusion (extracellular to cytosol)

845948
type: LocalParameter
value: 0.0

845936
type: LocalParameter
value: 0.0

845924
type: LocalParameter
value: 1000.0

845912
type: LocalParameter
value: -1000.0

845888
type: SpeciesReference
stoichiometry: 1.0
species: 768788

845876
type: SpeciesReference
stoichiometry: 1.0
species: 765696

765696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Phenylalanine

769258
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: triglyceride, human adipoctye

770177
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Fe2+

826469
type: Reaction
reactant: 826505
product: 826530
reactant: 826493
product: 826542
reactant: 826481
reversible: true
product: 826517
notes: GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Glutamate Metabolism
name: glutamate dehydrogenase (NADP), mitochondrial
fast: false
kinetic law: 826566
product: 826554

826505
type: SpeciesReference
stoichiometry: 1.0
species: 770647

770647
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Nicotinamide adenine dinucleotide phosphate

826530
type: SpeciesReference
stoichiometry: 1.0
species: 770333

826493
type: SpeciesReference
stoichiometry: 1.0
species: 770345

826542
type: SpeciesReference
stoichiometry: 1.0
species: 770659

770659
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Nicotinamide adenine dinucleotide phosphate - reduced

826481
type: SpeciesReference
stoichiometry: 1.0
species: 770261

826517
type: SpeciesReference
stoichiometry: 1.0
species: 769693

826614
type: LocalParameter
value: 0.0

826602
type: LocalParameter
value: 0.0

826590
type: LocalParameter
value: 1000.0

826578
type: LocalParameter
value: -1000.0

826554
type: SpeciesReference
stoichiometry: 1.0
species: 770671

798518
type: Reaction
reactant: 798530
product: 798566
reactant: 798542
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
fast: false
reversible: true
kinetic law: 798578
product: 798554
name: carnitine tetradecenoyltransferase (C14:1Crn, n5), mitochondrial

798530
type: SpeciesReference
stoichiometry: 1.0
species: 769863

798566
type: SpeciesReference
stoichiometry: 1.0
species: 771180

798542
type: SpeciesReference
stoichiometry: 1.0
species: 771168

771168
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: tetradecenoyl-CoA (C14:1CoA, n-5)

798626
type: LocalParameter
value: 0.0

798614
type: LocalParameter
value: 0.0

798602
type: LocalParameter
value: 1000.0

798590
type: LocalParameter
value: -1000.0

798554
type: SpeciesReference
stoichiometry: 1.0
species: 769851

772406
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: phe_L_b

774717
type: Reaction
kinetic law: 774754
product: 774742
reactant: 774730
fast: false
reversible: true
name: eicosatetraenoate (C20:4, n-6) exchange

774802
type: LocalParameter
value: 500.0

774790
type: LocalParameter
value: 0.0

774778
type: LocalParameter
value: 1000.0

774766
type: LocalParameter
value: 0.0

774742
type: SpeciesReference
stoichiometry: 1.0
species: 772020

772020
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ecsttea6_b

774730
type: SpeciesReference
stoichiometry: 1.0
species: 765309

765309
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: eicosatetraenoate (C20:4, n-6)

825945
type: Reaction
notes: GENE_ASSOCIATION: (NM_005628.1 or NM_018018.2) GENE_LIST: NM_005628.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
product: 825994
kinetic law: 826007
name: L-glutamine reversible transport via sodium symport, blood
product: 825982
reversible: true
fast: false
reactant: 825957
reactant: 825969

825994
type: SpeciesReference
stoichiometry: 1.0
species: 768286

826055
type: LocalParameter
value: 0.0

826043
type: LocalParameter
value: 0.0

826031
type: LocalParameter
value: 1000.0

826019
type: LocalParameter
value: -1000.0

825982
type: SpeciesReference
stoichiometry: 1.0
species: 767621

767621
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Glutamine

825957
type: SpeciesReference
stoichiometry: 1.0
species: 765357

765357
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Glutamine

825969
type: SpeciesReference
stoichiometry: 1.0
species: 765575

784252
type: Reaction
product: 784324
reactant: 784264
reversible: false
product: 784312
name: aldehyde dehydrogenase (NAD), mitochondrial
product: 784300
fast: false
notes: GENE_ASSOCIATION: (NM_000692.3 or NM_000690.2) GENE_LIST: NM_000690.2 NM_000692.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reactant: 784288
reactant: 784276
kinetic law: 784336

784324
type: SpeciesReference
stoichiometry: 1.0
species: 770634

784264
type: SpeciesReference
stoichiometry: 1.0
species: 770345

784312
type: SpeciesReference
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species: 770574

784300
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species: 770333

784288
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stoichiometry: 1.0
species: 770622

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stoichiometry: 1.0
species: 770586

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value: 500.0

784372
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value: 0.0

784360
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value: 1000.0

784348
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value: 0.0

768556
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoyl-CoA (C18:1CoA, n-5)

768372
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Superoxide

826188
type: Reaction
product: 826225
kinetic law: 826249
reversible: false
reactant: 826200
notes: GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Arginine and Proline Metabolism
name: glutamate 5-kinase, mitochondrial
fast: false
reactant: 826213
product: 826237

826225
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stoichiometry: 1.0
species: 769681

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value: 500.0

826287
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value: 0.0

826274
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value: 1000.0

826262
type: LocalParameter
value: 0.0

826200
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stoichiometry: 1.0
species: 769730

826213
type: SpeciesReference
stoichiometry: 1.0
species: 770261

826237
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stoichiometry: 1.0
species: 770273

770273
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Glutamate 5-phosphate

801129
type: Reaction
reactant: 801141
reactant: 801153
notes: GENE_ASSOCIATION: (NM_020244.2 or NM_006090.3 or NM_001007794.1) GENE_LIST: NM_001007794.1 NM_006090.3 NM_020244.2 SUBSYSTEM: Phospholipid Metabolism
name: diacylglycerol cholinephosphotransferase, human adipocyte
product: 801165
reversible: false
fast: false
kinetic law: 801201
product: 801177
product: 801189

801141
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stoichiometry: 0.001
species: 765864

765864
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 1,2-Diacylglycerol, human adipocyte

801153
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stoichiometry: 1.0
species: 766470

766470
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CDPcholine

801165
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stoichiometry: 1.0
species: 766592

766592
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CMP

801249
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value: 500.0

801237
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value: 0.0

801225
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value: 1000.0

801213
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value: 0.0

801177
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stoichiometry: 1.0
species: 767767

801189
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stoichiometry: 0.001
species: 768714

768714
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphatidylcholine, human adipoctye

775393
type: Reaction
kinetic law: 775429
product: 775417
reactant: 775405
fast: false
reversible: true
name: Glycerol exchange

775477
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value: 500.0

775465
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value: 0.0

775453
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value: 1000.0

775441
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value: 0.0

775417
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stoichiometry: 1.0
species: 772104

772104
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: glyc_b

775405
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stoichiometry: 1.0
species: 765394

765394
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Glycerol

770961
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: phosphatidylglycerol, human adipocyte

821705
type: Reaction
product: 821754
fast: false
reactant: 821730
reactant: 821718
name: formyltetrahydrofolate dehydrogenase
reactant: 821742
reversible: false
product: 821766
kinetic law: 821803
notes: GENE_ASSOCIATION: NM_012190.2 GENE_LIST: NM_012190.2 SUBSYSTEM: Folate Metabolism
product: 821791
product: 821778

821754
type: SpeciesReference
stoichiometry: 1.0
species: 766604

821730
type: SpeciesReference
stoichiometry: 1.0
species: 767779

821718
type: SpeciesReference
stoichiometry: 1.0
species: 765852

765852
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 10-Formyltetrahydrofolate

821742
type: SpeciesReference
stoichiometry: 1.0
species: 768323

821766
type: SpeciesReference
stoichiometry: 1.0
species: 767767

821851
type: LocalParameter
value: 500.0

821839
type: LocalParameter
value: 0.0

821827
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value: 1000.0

821815
type: LocalParameter
value: 0.0

821791
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stoichiometry: 1.0
species: 769198

769198
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5,6,7,8-Tetrahydrofolate

821778
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stoichiometry: 1.0
species: 768335

772214
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: hpdcea8_b

772467
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constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ser_L_b

829318
type: Reaction
kinetic law: 829354
product: 829342
reactant: 829330
notes: GENE_ASSOCIATION: (NM_000486.3 or NM_001650.4 or NM_001651.1 or NM_001170.1 or NM_080429.2 or NM_004028.3 or NM_001652.3 or NM_004925.3 or NM_001169.2 or NM_198098.1) GENE_LIST: NM_000486.3 NM_001169.2 NM_001170.1 NM_001650.4 NM_001651.1 NM_001652.3 NM_004028.3 NM_004925.3 NM_080429.2 NM_198098.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: H2O transport via diffusion

829403
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value: 0.0

829391
type: LocalParameter
value: 0.0

829379
type: LocalParameter
value: 1000.0

829366
type: LocalParameter
value: -1000.0

829342
type: SpeciesReference
stoichiometry: 1.0
species: 767779

829330
type: SpeciesReference
stoichiometry: 1.0
species: 765418

765418
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: H2O

813052
type: Reaction
reactant: 813088
product: 813149
name: Beta oxidation of odd chain fatty acid
reactant: 813113
reactant: 813100
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 813076
product: 813162
fast: false
product: 813175
reversible: false
reactant: 813064
kinetic law: 813187
product: 813137
product: 813125

813088
type: SpeciesReference
stoichiometry: 1.0
species: 770345

813149
type: SpeciesReference
stoichiometry: 1.0
species: 770165

813113
type: SpeciesReference
stoichiometry: 1.0
species: 771204

771204
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: tridecanoyl-CoA (C13:0CoA)

813100
type: SpeciesReference
stoichiometry: 1.0
species: 770622

813076
type: SpeciesReference
stoichiometry: 1.0
species: 770153

813162
type: SpeciesReference
stoichiometry: 1.0
species: 770333

813175
type: SpeciesReference
stoichiometry: 1.0
species: 770634

813064
type: SpeciesReference
stoichiometry: 1.0
species: 769851

813235
type: LocalParameter
value: 500.0

813223
type: LocalParameter
value: 0.0

813211
type: LocalParameter
value: 1000.0

813199
type: LocalParameter
value: 0.0

813137
type: SpeciesReference
stoichiometry: 1.0
species: 770019

770019
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: endecanoyl-CoA (C11:0CoA)

813125
type: SpeciesReference
stoichiometry: 1.0
species: 769657

809101
type: Reaction
product: 809162
fast: false
reversible: true
name: fatty-acid--CoA ligase (octadecadienoate, C18:2 n-6)
reactant: 809137
product: 809174
product: 809149
reactant: 809125
reactant: 809113
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_004457.3 or NM_203372.1 or NM_203379.1 or NM_004458.1 or NM_015256.2 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
kinetic law: 809186

809162
type: SpeciesReference
stoichiometry: 1.0
species: 768470

768470
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecadienoyl-CoA (C18:2CoA, n-6)

809137
type: SpeciesReference
stoichiometry: 1.0
species: 768458

768458
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecadienoate (C18:2, n-6)

809174
type: SpeciesReference
stoichiometry: 1.0
species: 768885

809149
type: SpeciesReference
stoichiometry: 1.0
species: 766338

809125
type: SpeciesReference
stoichiometry: 1.0
species: 766616

809113
type: SpeciesReference
stoichiometry: 1.0
species: 766398

809235
type: LocalParameter
value: 0.0

809223
type: LocalParameter
value: 0.0

809211
type: LocalParameter
value: 1000.0

809198
type: LocalParameter
value: -1000.0

772334
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocdcea5_b

772503
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: trp_L_b

775297
type: Reaction
kinetic law: 775333
product: 775321
reactant: 775309
fast: false
reversible: true
name: Glycine exchange

775381
type: LocalParameter
value: 500.0

775369
type: LocalParameter
value: 0.0

775357
type: LocalParameter
value: 1000.0

775345
type: LocalParameter
value: 0.0

775321
type: SpeciesReference
stoichiometry: 1.0
species: 772092

772092
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: gly_b

775309
type: SpeciesReference
stoichiometry: 1.0
species: 765382

765382
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Glycine

794152
type: Reaction
name: carnitine hexadecenoyltransferase (C16:1Crn, n7)
reactant: 794176
product: 794200
reactant: 794164
kinetic law: 794212
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_001031847.1 or NM_001876.2 or NM_152245.1 or NM_152246.1 or NM_152359.1 or NM_004377.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
product: 794188
fast: false

794176
type: SpeciesReference
stoichiometry: 1.0
species: 767864

767864
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoyl-CoA (C16:1CoA, n-7)

794200
type: SpeciesReference
stoichiometry: 1.0
species: 767888

767888
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoyl carnitine (C16:1Crn, n-7)

794164
type: SpeciesReference
stoichiometry: 1.0
species: 766628

794260
type: LocalParameter
value: 0.0

794248
type: LocalParameter
value: 0.0

794236
type: LocalParameter
value: 1000.0

794224
type: LocalParameter
value: -1000.0

794188
type: SpeciesReference
stoichiometry: 1.0
species: 766616

805938
type: Reaction
product: 805974
reactant: 805950
name: diphosphomevalonate decarboxylase
kinetic law: 806022
fast: false
reactant: 805962
reversible: false
notes: SUBSYSTEM: Cholesterol Metabolism
product: 805986
product: 805998
product: 806010

805974
type: SpeciesReference
stoichiometry: 1.0
species: 771648

771648
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: ADP

805950
type: SpeciesReference
stoichiometry: 1.0
species: 771624

771624
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: (R)-5-Diphosphomevalonate

806070
type: LocalParameter
value: 500.0

806058
type: LocalParameter
value: 0.0

806046
type: LocalParameter
value: 1000.0

806034
type: LocalParameter
value: 0.0

805962
type: SpeciesReference
stoichiometry: 1.0
species: 771660

771660
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: ATP

805986
type: SpeciesReference
stoichiometry: 1.0
species: 771672

771672
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: CO2

805998
type: SpeciesReference
stoichiometry: 1.0
species: 771756

771756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Isopentenyl diphosphate

806010
type: SpeciesReference
stoichiometry: 1.0
species: 771804

771804
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Phosphate

848763
type: Reaction
name: phosphoribosylformylglycinamidine synthase
fast: false
product: 848872
reactant: 848799
kinetic law: 848884
reversible: false
reactant: 848775
product: 848823
product: 848847
notes: GENE_ASSOCIATION: NM_012393.1 GENE_LIST: NM_012393.1 SUBSYSTEM: Nucleotide Metabolism
product: 848835
product: 848859
reactant: 848811
reactant: 848787

848872
type: SpeciesReference
stoichiometry: 1.0
species: 768800

848799
type: SpeciesReference
stoichiometry: 1.0
species: 767621

848932
type: LocalParameter
value: 500.0

848920
type: LocalParameter
value: 0.0

848908
type: LocalParameter
value: 1000.0

848896
type: LocalParameter
value: 0.0

848775
type: SpeciesReference
stoichiometry: 1.0
species: 766398

848823
type: SpeciesReference
stoichiometry: 1.0
species: 766240

848847
type: SpeciesReference
stoichiometry: 1.0
species: 767633

848835
type: SpeciesReference
stoichiometry: 1.0
species: 767500

767500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine

848859
type: SpeciesReference
stoichiometry: 2.0
species: 767767

848811
type: SpeciesReference
stoichiometry: 1.0
species: 767779

848787
type: SpeciesReference
stoichiometry: 1.0
species: 767464

767464
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide

782847
type: Reaction
name: adenosylhomocysteinase
reactant: 782859
reversible: true
product: 782896
reactant: 782871
product: 782883
kinetic law: 782908
notes: GENE_ASSOCIATION: (NM_006621.3 or NM_015328.1 or NM_000687.1) GENE_LIST: NM_000687.1 NM_006621.3 NM_015328.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false

782859
type: SpeciesReference
stoichiometry: 1.0
species: 766252

766252
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: S-Adenosyl-L-homocysteine

782896
type: SpeciesReference
stoichiometry: 1.0
species: 767815

767815
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Homocysteine

782871
type: SpeciesReference
stoichiometry: 1.0
species: 767779

782883
type: SpeciesReference
stoichiometry: 1.0
species: 766228

766228
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Adenosine

782956
type: LocalParameter
value: 0.0

782944
type: LocalParameter
value: 0.0

782932
type: LocalParameter
value: 1000.0

782920
type: LocalParameter
value: -1000.0

768909
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Phospho-beta-D-ribosylamine

828631
type: Reaction
reactant: 828643
fast: false
reactant: 828655
product: 828691
reactant: 828667
product: 828679
reversible: false
name: glutathione oxidoreductase
notes: GENE_ASSOCIATION: NM_000637.2 GENE_LIST: NM_000637.2 SUBSYSTEM: Cysteine Metabolism
kinetic law: 828703

828643
type: SpeciesReference
stoichiometry: 1.0
species: 767731

767731
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Oxidized glutathione

828655
type: SpeciesReference
stoichiometry: 1.0
species: 767767

828691
type: SpeciesReference
stoichiometry: 1.0
species: 768323

828667
type: SpeciesReference
stoichiometry: 1.0
species: 768335

828679
type: SpeciesReference
stoichiometry: 2.0
species: 767743

828751
type: LocalParameter
value: 500.0

828739
type: LocalParameter
value: 0.0

828727
type: LocalParameter
value: 1000.0

828715
type: LocalParameter
value: 0.0

845500
type: Reaction
kinetic law: 845536
product: 845524
reactant: 845512
notes: GENE_ASSOCIATION: (NM_018290.2 or NM_002633.2) GENE_LIST: NM_002633.2 NM_018290.2 SUBSYSTEM: Glycogen Metabolism
fast: false
reversible: true
name: phosphoglucomutase

845585
type: LocalParameter
value: 0.0

845573
type: LocalParameter
value: 0.0

845560
type: LocalParameter
value: 1000.0

845548
type: LocalParameter
value: -1000.0

845524
type: SpeciesReference
stoichiometry: 1.0
species: 767573

845512
type: SpeciesReference
stoichiometry: 1.0
species: 767549

767549
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Glucose 1-phosphate

777618
type: Reaction
kinetic law: 777655
product: 777643
reactant: 777630
fast: false
reversible: true
name: octadecadienoate (C18:2, n-6) exchange

777703
type: LocalParameter
value: -0.00343343205

777691
type: LocalParameter
value: 0.0

777679
type: LocalParameter
value: 0.0

777667
type: LocalParameter
value: -0.0068668641

777643
type: SpeciesReference
stoichiometry: 1.0
species: 772382

772382
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocddea6_b

777630
type: SpeciesReference
stoichiometry: 1.0
species: 765672

765672
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecadienoate (C18:2, n-6)

768690
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphatidate, adipocyte

766724
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dCDP

784396
type: Reaction
fast: false
notes: GENE_ASSOCIATION: NM_001159.3 GENE_LIST: NM_001159.3 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
reversible: false
reactant: 784408
reactant: 784420
name: aldehyde oxidase
kinetic law: 784480
product: 784468
reactant: 784432
product: 784444
product: 784456

784408
type: SpeciesReference
stoichiometry: 1.0
species: 767779

784420
type: SpeciesReference
stoichiometry: 1.0
species: 768262

768262
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (S)-Methylmalonate semialdehyde

784529
type: LocalParameter
value: 500.0

784516
type: LocalParameter
value: 0.0

784504
type: LocalParameter
value: 1000.0

784492
type: LocalParameter
value: 0.0

784468
type: SpeciesReference
stoichiometry: 1.0
species: 768250

784432
type: SpeciesReference
stoichiometry: 1.0
species: 768359

784444
type: SpeciesReference
stoichiometry: 1.0
species: 767767

784456
type: SpeciesReference
stoichiometry: 1.0
species: 767791

767791
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Hydrogen peroxide

826993
type: Reaction
kinetic law: 827054
name: L-glutamate reversible transport via proton symport, mitochondrial
reactant: 827005
product: 827030
notes: GENE_ASSOCIATION: (NM_031481.1 or NM_024698.4) GENE_LIST: NM_024698.4 NM_031481.1 SUBSYSTEM: Transport, Mitochondrial
product: 827042
reversible: true
fast: false
reactant: 827017

827102
type: LocalParameter
value: 0.0

827090
type: LocalParameter
value: 0.0

827078
type: LocalParameter
value: 1000.0

827066
type: LocalParameter
value: -1000.0

827005
type: SpeciesReference
stoichiometry: 1.0
species: 767633

827030
type: SpeciesReference
stoichiometry: 1.0
species: 770261

827042
type: SpeciesReference
stoichiometry: 1.0
species: 770333

827017
type: SpeciesReference
stoichiometry: 1.0
species: 767767

818456
type: Reaction
reactant: 818505
reactant: 818493
name: fatty acid synthase (n-C10:0)
kinetic law: 818577
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
product: 818541
product: 818565
product: 818529
fast: false
product: 818553
reactant: 818468
reversible: false
product: 818517
reactant: 818481

818505
type: SpeciesReference
stoichiometry: 1.0
species: 768508

768508
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octanoate

818493
type: SpeciesReference
stoichiometry: 2.0
species: 768335

818625
type: LocalParameter
value: 500.0

818613
type: LocalParameter
value: 0.0

818601
type: LocalParameter
value: 1000.0

818589
type: LocalParameter
value: 0.0

818541
type: SpeciesReference
stoichiometry: 1.0
species: 766700

818565
type: SpeciesReference
stoichiometry: 2.0
species: 768323

818529
type: SpeciesReference
stoichiometry: 1.0
species: 766616

818553
type: SpeciesReference
stoichiometry: 1.0
species: 767779

818468
type: SpeciesReference
stoichiometry: 3.0
species: 767767

818517
type: SpeciesReference
stoichiometry: 1.0
species: 766604

818481
type: SpeciesReference
stoichiometry: 1.0
species: 768154

796701
type: Reaction
kinetic law: 796762
reactant: 796713
product: 796750
fast: false
reversible: true
product: 796738
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_152247.1 or NM_001876.2 or NM_152246.1 or NM_004377.2 or NM_001031847.1 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 796725
name: carnitine ocosatetraenoyltransferase (C22:4Crn, n6)

796810
type: LocalParameter
value: 0.0

796798
type: LocalParameter
value: 0.0

796786
type: LocalParameter
value: 1000.0

796774
type: LocalParameter
value: -1000.0

796713
type: SpeciesReference
stoichiometry: 1.0
species: 766628

796750
type: SpeciesReference
stoichiometry: 1.0
species: 768678

768678
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ocosatetraenoyl carnitine (C22:4Crn, n-6)

796738
type: SpeciesReference
stoichiometry: 1.0
species: 766616

796725
type: SpeciesReference
stoichiometry: 1.0
species: 768666

770007
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosanoylcarnitine, C20:0crn

775781
type: Reaction
kinetic law: 775817
product: 775805
reactant: 775793
fast: false
reversible: true
name: hexadecanoate (n-C16:0) exchange

775866
type: LocalParameter
value: 500.0

775854
type: LocalParameter
value: 0.0

775841
type: LocalParameter
value: 1000.0

775829
type: LocalParameter
value: 0.0

775805
type: SpeciesReference
stoichiometry: 1.0
species: 772153

772153
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: hdca_b

775793
type: SpeciesReference
stoichiometry: 1.0
species: 765442

765442
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: hexadecanoate (n-C16:0)

769065
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sphingomyeline, adipocyte

831010
type: Reaction
reactant: 831034
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_007231.1 or NM_018976.3) GENE_LIST: NM_007231.1 NM_018018.2 NM_018976.3 SUBSYSTEM: Transport, Extracellular
reactant: 831022
name: L-histidine transport in via sodium symport, blood
product: 831058
kinetic law: 831070
product: 831046
fast: false
reversible: true

831034
type: SpeciesReference
stoichiometry: 1.0
species: 765575

831022
type: SpeciesReference
stoichiometry: 1.0
species: 765479

765479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Histidine

831058
type: SpeciesReference
stoichiometry: 1.0
species: 768286

831118
type: LocalParameter
value: 0.0

831106
type: LocalParameter
value: 0.0

831094
type: LocalParameter
value: 1000.0

831082
type: LocalParameter
value: -1000.0

831046
type: SpeciesReference
stoichiometry: 1.0
species: 767924

767924
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Histidine

791129
type: Reaction
reactant: 791153
product: 791165
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001876.2 or NM_001031847.1 or NM_004377.2 or NM_152359.1 or NM_152247.1 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 791141
kinetic law: 791189
product: 791177
name: carnitine docosahexaenoyltransferase (C22:6Crn, n3)
reversible: true
fast: false

791153
type: SpeciesReference
stoichiometry: 1.0
species: 766992

766992
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosahexaenoyl-CoA (C22:6CoA, n-3)

791165
type: SpeciesReference
stoichiometry: 1.0
species: 766616

791141
type: SpeciesReference
stoichiometry: 1.0
species: 766628

791237
type: LocalParameter
value: 0.0

791225
type: LocalParameter
value: 0.0

791213
type: LocalParameter
value: 1000.0

791201
type: LocalParameter
value: -1000.0

791177
type: SpeciesReference
stoichiometry: 1.0
species: 767004

767004
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosahexaenoyl carnitine (C22:6Crn, n-3)

810983
type: Reaction
reactant: 811068
reactant: 811189
reactant: 811201
reactant: 811080
kinetic law: 811346
product: 811321
reactant: 811140
reactant: 811044
reactant: 811019
reactant: 811165
reactant: 811116
reactant: 810995
reactant: 811153
reactant: 811104
reactant: 811225
name: Average fatty acyl-coa, human adipocyte
fast: false
reactant: 811213
reactant: 811128
reactant: 811249
reactant: 811092
product: 811334
product: 811309
reactant: 811273
reactant: 811056
reactant: 811297
reactant: 811007
reactant: 811237
reversible: true
reactant: 811285
reactant: 811261
notes: GENE_ASSOCIATION: (NM_004457.3 or NM_203379.1 or NM_203372.1 or NM_203380.1 or NM_001995.2 or NM_004458.1 or NM_022977.1 or NM_016234.3) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Biosynthesis
reactant: 811031
reactant: 811177

811068
type: SpeciesReference
stoichiometry: 0.002
species: 767112

811189
type: SpeciesReference
stoichiometry: 0.064
species: 768397

811201
type: SpeciesReference
stoichiometry: 0.003
species: 768409

811080
type: SpeciesReference
stoichiometry: 0.003
species: 767151

767151
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosadienoate (C20:2, n-6)

811394
type: LocalParameter
value: 0.0

811382
type: LocalParameter
value: 0.0

811370
type: LocalParameter
value: 1000.0

811358
type: LocalParameter
value: -1000.0

811321
type: SpeciesReference
stoichiometry: 0.001
species: 767416

767416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: average fatty-acyl CoA, human adipocyte

811140
type: SpeciesReference
stoichiometry: 0.243
species: 767827

811044
type: SpeciesReference
stoichiometry: 0.002
species: 766809

811019
type: SpeciesReference
stoichiometry: 0.001
species: 766784

766784
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosenoate (C22:1, n-9)

811165
type: SpeciesReference
stoichiometry: 0.005
species: 767851

767851
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoate (C16:1, n-9)

811116
type: SpeciesReference
stoichiometry: 0.003
species: 767189

767189
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatrienoate (C20:3, n-6)

810995
type: SpeciesReference
stoichiometry: 1.0
species: 766398

811153
type: SpeciesReference
stoichiometry: 0.03
species: 767839

767839
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoate (C16:1, n-7)

811104
type: SpeciesReference
stoichiometry: 0.007
species: 767177

811225
type: SpeciesReference
stoichiometry: 0.393
species: 768433

768433
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoate (C18:1, n-9)

811213
type: SpeciesReference
stoichiometry: 0.018
species: 768421

768421
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoate (C18:1, n-7)

811128
type: SpeciesReference
stoichiometry: 0.004
species: 767202

811249
type: SpeciesReference
stoichiometry: 0.159
species: 768458

811092
type: SpeciesReference
stoichiometry: 0.002
species: 767164

767164
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoate (C20:1, n-11)

811334
type: SpeciesReference
stoichiometry: 1.0
species: 768885

811309
type: SpeciesReference
stoichiometry: 1.0
species: 766338

811273
type: SpeciesReference
stoichiometry: 0.003
species: 768969

768969
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: pentadecanoate (C15:0)

811056
type: SpeciesReference
stoichiometry: 0.007
species: 766833

811297
type: SpeciesReference
stoichiometry: 0.002
species: 769306

769306
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: tetradecenoate (C14:1, n-5)

811007
type: SpeciesReference
stoichiometry: 1.0
species: 766616

811237
type: SpeciesReference
stoichiometry: 0.005
species: 768446

768446
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecatrienoate (C18:3, n-3)

811285
type: SpeciesReference
stoichiometry: 0.037
species: 769294

769294
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: tetradecanoate (C14:0)

811261
type: SpeciesReference
stoichiometry: 0.002
species: 768495

811031
type: SpeciesReference
stoichiometry: 0.002
species: 766796

766796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosahexaenoate (C22:6, n-3)

811177
type: SpeciesReference
stoichiometry: 0.003
species: 767972

767972
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: heptadecenoate (C17:1, n-8)

803710
type: Reaction
notes: GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
kinetic law: 803808
reactant: 803734
reversible: false
reactant: 803759
product: 803772
product: 803784
reactant: 803722
fast: false
product: 803796
name: stearoyl-CoA desaturase (C18:3CoA, n3 -> C18:4CoA, n3)
reactant: 803747

803856
type: LocalParameter
value: 500.0

803844
type: LocalParameter
value: 0.0

803832
type: LocalParameter
value: 1000.0

803820
type: LocalParameter
value: 0.0

803734
type: SpeciesReference
stoichiometry: 1.0
species: 768335

803759
type: SpeciesReference
stoichiometry: 1.0
species: 768520

768520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecatrienoyl-CoA (C18:3CoA, n-3)

803772
type: SpeciesReference
stoichiometry: 2.0
species: 767779

803784
type: SpeciesReference
stoichiometry: 1.0
species: 768323

803722
type: SpeciesReference
stoichiometry: 1.0
species: 767767

803796
type: SpeciesReference
stoichiometry: 1.0
species: 769125

769125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: stearidonyl coenzyme A (C18:4CoA, n-3)

803747
type: SpeciesReference
stoichiometry: 1.0
species: 768359

770756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecadienoyl carnitine (C18:2Crn, n-6)

841222
type: Reaction
product: 841282
kinetic law: 841294
notes: SUBSYSTEM: Nucleotide Metabolism
reversible: false
reactant: 841234
name: Nucleoside triphosphate pyrophosphorylase (atp)
product: 841270
reactant: 841246
product: 841258
fast: false

841282
type: SpeciesReference
stoichiometry: 1.0
species: 771046

771046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Diphosphate

841342
type: LocalParameter
value: 500.0

841330
type: LocalParameter
value: 0.0

841318
type: LocalParameter
value: 1000.0

841306
type: LocalParameter
value: 0.0

841234
type: SpeciesReference
stoichiometry: 1.0
species: 769730

841270
type: SpeciesReference
stoichiometry: 1.0
species: 770333

841246
type: SpeciesReference
stoichiometry: 1.0
species: 770345

841258
type: SpeciesReference
stoichiometry: 1.0
species: 769706

778681
type: Reaction
kinetic law: 778717
product: 778705
reactant: 778693
fast: false
reversible: true
name: tetradecanoate (C14:0) exchange

778766
type: LocalParameter
value: 500.0

778754
type: LocalParameter
value: 0.0

778741
type: LocalParameter
value: 1000.0

778729
type: LocalParameter
value: 0.0

778705
type: SpeciesReference
stoichiometry: 1.0
species: 772515

772515
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ttdca_b

778693
type: SpeciesReference
stoichiometry: 1.0
species: 765804

765804
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: tetradecanoate (C14:0)

823952
type: Reaction
fast: false
name: glucose 6-phosphate dehydrogenase
product: 824000
product: 823988
reactant: 823964
kinetic law: 824024
notes: GENE_ASSOCIATION: (NM_001042351.1 or NM_000402.2) GENE_LIST: NM_000402.2 NM_001042351.1 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 823976
reversible: true
product: 824012

824000
type: SpeciesReference
stoichiometry: 1.0
species: 767767

823988
type: SpeciesReference
stoichiometry: 1.0
species: 766107

766107
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 6-phospho-D-glucono-1,5-lactone

823964
type: SpeciesReference
stoichiometry: 1.0
species: 767573

824072
type: LocalParameter
value: 0.0

824060
type: LocalParameter
value: 0.0

824048
type: LocalParameter
value: 1000.0

824036
type: LocalParameter
value: -1000.0

823976
type: SpeciesReference
stoichiometry: 1.0
species: 768323

824012
type: SpeciesReference
stoichiometry: 1.0
species: 768335

783355
type: Reaction
kinetic law: 783391
product: 783379
reactant: 783367
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: alphaketobutyrate transport (mitochondrial)

783439
type: LocalParameter
value: 0.0

783427
type: LocalParameter
value: 0.0

783415
type: LocalParameter
value: 1000.0

783403
type: LocalParameter
value: -1000.0

783379
type: SpeciesReference
stoichiometry: 1.0
species: 765925

765925
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 2-Oxobutanoate

783367
type: SpeciesReference
stoichiometry: 1.0
species: 769513

769513
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 2-Oxobutanoate

778101
type: Reaction
kinetic law: 778138
product: 778126
reactant: 778113
fast: false
reversible: true
name: L-Proline exchange

778187
type: LocalParameter
value: 500.0

778174
type: LocalParameter
value: 0.0

778162
type: LocalParameter
value: 1000.0

778150
type: LocalParameter
value: 0.0

778126
type: SpeciesReference
stoichiometry: 1.0
species: 772442

772442
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: pro_L_b

778113
type: SpeciesReference
stoichiometry: 1.0
species: 765732

765732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Proline

772540
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: tyr_L_b

770381
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: hexadecenoyl-CoA (C16:1CoA, n-7)

791731
type: Reaction
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 791780
fast: false
name: docosapentaenoyl carnitine transport (C22:5Crn, n3)
reactant: 791756
reversible: true
kinetic law: 791792
product: 791768
reactant: 791744

791780
type: SpeciesReference
stoichiometry: 1.0
species: 769983

769983
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosapentaenoyl carnitine (C22:5Crn, n-3)

791756
type: SpeciesReference
stoichiometry: 1.0
species: 769863

791840
type: LocalParameter
value: 0.0

791828
type: LocalParameter
value: 0.0

791816
type: LocalParameter
value: 1000.0

791804
type: LocalParameter
value: -1000.0

791768
type: SpeciesReference
stoichiometry: 1.0
species: 766628

791744
type: SpeciesReference
stoichiometry: 1.0
species: 767028

767028
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosapentaenoyl carnitine (C22:5Crn, n-3)

774910
type: Reaction
kinetic law: 774947
product: 774935
reactant: 774923
fast: false
reversible: true
name: Fe2+ exchange

774995
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value: 0.0

774983
type: LocalParameter
value: 0.0

774971
type: LocalParameter
value: 1000.0

774959
type: LocalParameter
value: -1000.0

774935
type: SpeciesReference
stoichiometry: 1.0
species: 772044

774923
type: SpeciesReference
stoichiometry: 1.0
species: 765333

770853
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl carnitine (C18:1Crn, n9)

766216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: O-Acetylcarnitine

772527
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ttdcea5_b

776071
type: Reaction
kinetic law: 776107
product: 776095
reactant: 776083
fast: false
reversible: true
name: L-Histidine exchange

776155
type: LocalParameter
value: -3.257465E-5

776143
type: LocalParameter
value: 0.0

776131
type: LocalParameter
value: 0.0

776119
type: LocalParameter
value: -6.51493E-5

776095
type: SpeciesReference
stoichiometry: 1.0
species: 772189

772189
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: his_L_b

776083
type: SpeciesReference
stoichiometry: 1.0
species: 765479

770973
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Phosphatidylglycerophosphate, human adipocyte

792214
type: Reaction
product: 792262
reactant: 792226
reactant: 792238
reversible: true
product: 792250
name: eicosenoyl carnitine transport (C20:1Crn, n11)
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
fast: false
kinetic law: 792274

792262
type: SpeciesReference
stoichiometry: 1.0
species: 770081

770081
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosenoyl carnitine (C20:1Crn, n-11)

792226
type: SpeciesReference
stoichiometry: 1.0
species: 767267

767267
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoyl carnitine (C20:1Crn, n-11)

792238
type: SpeciesReference
stoichiometry: 1.0
species: 769863

792250
type: SpeciesReference
stoichiometry: 1.0
species: 766628

792323
type: LocalParameter
value: 0.0

792311
type: LocalParameter
value: 0.0

792299
type: LocalParameter
value: 1000.0

792286
type: LocalParameter
value: -1000.0

785975
type: Reaction
reactant: 785987
kinetic law: 786036
fast: false
product: 786012
product: 786024
name: aspartate transaminase
reversible: true
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Asparagine Metabolism
reactant: 786000

785987
type: SpeciesReference
stoichiometry: 1.0
species: 766300

786085
type: LocalParameter
value: 0.0

786073
type: LocalParameter
value: 0.0

786061
type: LocalParameter
value: 1000.0

786049
type: LocalParameter
value: -1000.0

786012
type: SpeciesReference
stoichiometry: 1.0
species: 767633

786024
type: SpeciesReference
stoichiometry: 1.0
species: 768166

768166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Mercaptopyruvate

786000
type: SpeciesReference
stoichiometry: 1.0
species: 766652

766652
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Cysteine

768812
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: phosphatidyl-1D-myo-inositol, human adipocyte

807223
type: Reaction
product: 807295
product: 807283
reactant: 807247
reversible: true
product: 807271
reactant: 807259
kinetic law: 807307
name: fatty-acid--CoA ligase (dodecanoate, C12:0)
reactant: 807235
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_016234.3 or NM_004457.3 or NM_203372.1 or NM_004458.1 or NM_203379.1 or NM_203380.1 or NM_001009185.1 or NM_015256.2 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
fast: false

807295
type: SpeciesReference
stoichiometry: 1.0
species: 768885

807283
type: SpeciesReference
stoichiometry: 1.0
species: 766846

807247
type: SpeciesReference
stoichiometry: 1.0
species: 766616

807271
type: SpeciesReference
stoichiometry: 1.0
species: 766338

807259
type: SpeciesReference
stoichiometry: 1.0
species: 766833

807356
type: LocalParameter
value: 0.0

807344
type: LocalParameter
value: 0.0

807331
type: LocalParameter
value: 1000.0

807319
type: LocalParameter
value: -1000.0

807235
type: SpeciesReference
stoichiometry: 1.0
species: 766398

782180
type: Reaction
kinetic law: 782229
product: 782217
product: 782204
reactant: 782192
notes: GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: adenylosuccinate lyase

782277
type: LocalParameter
value: 0.0

782265
type: LocalParameter
value: 0.0

782253
type: LocalParameter
value: 1000.0

782241
type: LocalParameter
value: -1000.0

782217
type: SpeciesReference
stoichiometry: 1.0
species: 767537

782204
type: SpeciesReference
stoichiometry: 1.0
species: 766276

766276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide

782192
type: SpeciesReference
stoichiometry: 1.0
species: 765913

841547
type: Reaction
kinetic law: 841586
product: 841573
reactant: 841560
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: O2 transport, peroxisomal

841638
type: LocalParameter
value: 0.0

841625
type: LocalParameter
value: 0.0

841612
type: LocalParameter
value: 1000.0

841599
type: LocalParameter
value: -1000.0

841573
type: SpeciesReference
stoichiometry: 1.0
species: 771780

841560
type: SpeciesReference
stoichiometry: 1.0
species: 768359

766748
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dCMP

770489
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Isocitrate

775974
type: Reaction
kinetic law: 776010
product: 775998
reactant: 775986
fast: false
reversible: true
name: hexadecenoate (C16:1, n-9) exchange

776059
type: LocalParameter
value: 500.0

776047
type: LocalParameter
value: 0.0

776034
type: LocalParameter
value: 1000.0

776022
type: LocalParameter
value: 0.0

775998
type: SpeciesReference
stoichiometry: 1.0
species: 772177

775986
type: SpeciesReference
stoichiometry: 1.0
species: 765467

765467
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: hexadecenoate (C16:1, n-9)

765201
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Cysteine

826067
type: Reaction
reactant: 826091
product: 826103
product: 826116
kinetic law: 826128
fast: false
reversible: true
name: Glutamine transport, proton coupled, mitochondria
reactant: 826079
notes: SUBSYSTEM: Transport, Mitochondrial

826091
type: SpeciesReference
stoichiometry: 1.0
species: 767767

826103
type: SpeciesReference
stoichiometry: 1.0
species: 770249

826116
type: SpeciesReference
stoichiometry: 1.0
species: 770333

826176
type: LocalParameter
value: 0.0

826164
type: LocalParameter
value: 0.0

826152
type: LocalParameter
value: 1000.0

826140
type: LocalParameter
value: -1000.0

826079
type: SpeciesReference
stoichiometry: 1.0
species: 767621

845403
type: Reaction
kinetic law: 845439
product: 845427
reactant: 845415
notes: GENE_ASSOCIATION: (NM_199186.1 or NM_001724.3 or NM_000290.2 or NM_001029891.2 or NM_002629.2) GENE_LIST: NM_000290.2 NM_001029891.2 NM_001724.3 NM_002629.2 NM_199186.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: phosphoglycerate mutase

845488
type: LocalParameter
value: 0.0

845476
type: LocalParameter
value: 0.0

845463
type: LocalParameter
value: 1000.0

845451
type: LocalParameter
value: -1000.0

845427
type: SpeciesReference
stoichiometry: 1.0
species: 765938

765938
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Glycerate 2-phosphate

845415
type: SpeciesReference
stoichiometry: 1.0
species: 765974

765974
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Phospho-D-glycerate

833384
type: Reaction
kinetic law: 833420
product: 833408
reactant: 833396
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: isopentenyl diphosphate transport, peroxisome

833468
type: LocalParameter
value: 0.0

833456
type: LocalParameter
value: 0.0

833444
type: LocalParameter
value: 1000.0

833432
type: LocalParameter
value: -1000.0

833408
type: SpeciesReference
stoichiometry: 1.0
species: 768082

768082
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Isopentenyl diphosphate

833396
type: SpeciesReference
stoichiometry: 1.0
species: 771756

765962
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Dehydrosphinganine

801008
type: Reaction
kinetic law: 801069
notes: SUBSYSTEM: Nucleotide Metabolism
name: cytidylate kinase (CMP)(GTP)
product: 801045
product: 801057
reactant: 801020
reversible: true
reactant: 801033
fast: false

801117
type: LocalParameter
value: 0.0

801105
type: LocalParameter
value: 0.0

801093
type: LocalParameter
value: 1000.0

801081
type: LocalParameter
value: -1000.0

801045
type: SpeciesReference
stoichiometry: 1.0
species: 766458

801057
type: SpeciesReference
stoichiometry: 1.0
species: 767597

767597
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: GDP

801020
type: SpeciesReference
stoichiometry: 1.0
species: 766592

801033
type: SpeciesReference
stoichiometry: 1.0
species: 767755

767755
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: GTP

765503
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: heptadecenoate (C17:1, n-8)

777137
type: Reaction
kinetic law: 777173
product: 777161
reactant: 777149
fast: false
reversible: true
name: octadecanoate (n-C18:0) exchange

777221
type: LocalParameter
value: 500.0

777209
type: LocalParameter
value: 0.0

777197
type: LocalParameter
value: 1000.0

777185
type: LocalParameter
value: 0.0

777161
type: SpeciesReference
stoichiometry: 1.0
species: 772322

772322
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocdca_b

777149
type: SpeciesReference
stoichiometry: 1.0
species: 765611

824601
type: Reaction
product: 824650
reactant: 824613
product: 824662
notes: GENE_ASSOCIATION: (NM_175085.1 or NM_000819.3) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
product: 824637
fast: false
name: phosphoribosylglycinamide formyltransferase, irreversible
reversible: false
reactant: 824625
kinetic law: 824674

824650
type: SpeciesReference
stoichiometry: 1.0
species: 767767

824613
type: SpeciesReference
stoichiometry: 1.0
species: 765852

824662
type: SpeciesReference
stoichiometry: 1.0
species: 769198

824637
type: SpeciesReference
stoichiometry: 1.0
species: 767464

824625
type: SpeciesReference
stoichiometry: 1.0
species: 767585

767585
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N1-(5-Phospho-D-ribosyl)glycinamide

824723
type: LocalParameter
value: 500.0

824711
type: LocalParameter
value: 0.0

824699
type: LocalParameter
value: 1000.0

824687
type: LocalParameter
value: 0.0

769089
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Sulfinylpyruvate

771312
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 7-Dehydrocholesterol

854958
type: Reaction
fast: false
kinetic law: 855033
product: 854994
reversible: false
notes: GENE_ASSOCIATION: (NM_032564.2 or NM_178176.2 or NM_012079.3) GENE_LIST: NM_012079.3 NM_032564.2 NM_178176.2 SUBSYSTEM: Triacylglycerol Synthesis
reactant: 854970
product: 855006
reactant: 854982
name: triglycerol synthesis, endoplasmic reticulum, adipocyte

855081
type: LocalParameter
value: 500.0

855069
type: LocalParameter
value: 0.0

855057
type: LocalParameter
value: 1000.0

855045
type: LocalParameter
value: 0.0

854994
type: SpeciesReference
stoichiometry: 1.0
species: 766616

854970
type: SpeciesReference
stoichiometry: 0.001
species: 765864

855006
type: SpeciesReference
stoichiometry: 0.001
species: 769258

854982
type: SpeciesReference
stoichiometry: 0.001
species: 767416

798881
type: Reaction
reversible: true
reactant: 798906
kinetic law: 798942
product: 798930
reactant: 798893
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine tetradecanoyltransferase (C14:0Crn, mitochondria
fast: false
product: 798918

798906
type: SpeciesReference
stoichiometry: 1.0
species: 771156

771156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: tetradecanoylcarnitine (C14:0Crn)

798991
type: LocalParameter
value: 0.0

798979
type: LocalParameter
value: 0.0

798967
type: LocalParameter
value: 1000.0

798955
type: LocalParameter
value: -1000.0

798930
type: SpeciesReference
stoichiometry: 1.0
species: 771144

771144
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Tetradecanoyl-CoA (n-C14:0CoA)

798893
type: SpeciesReference
stoichiometry: 1.0
species: 769851

798918
type: SpeciesReference
stoichiometry: 1.0
species: 769863

768873
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Propanoyl-CoA (C3:0CoA)

770141
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)

770937
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: pentadecanoylcarnitine (C15:0Crn)

822575
type: Reaction
kinetic law: 822647
reactant: 822587
product: 822611
product: 822635
reactant: 822599
notes: GENE_ASSOCIATION: NM_000137.1 GENE_LIST: NM_000137.1 SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: false
product: 822623
name: fumarylacetoacetase

822696
type: LocalParameter
value: 500.0

822683
type: LocalParameter
value: 0.0

822671
type: LocalParameter
value: 1000.0

822659
type: LocalParameter
value: 0.0

822587
type: SpeciesReference
stoichiometry: 1.0
species: 766010

766010
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 4-Fumarylacetoacetate

822611
type: SpeciesReference
stoichiometry: 1.0
species: 766180

766180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetoacetate

822635
type: SpeciesReference
stoichiometry: 1.0
species: 767767

822599
type: SpeciesReference
stoichiometry: 1.0
species: 767779

822623
type: SpeciesReference
stoichiometry: 1.0
species: 767537

796944
type: Reaction
kinetic law: 797006
reactant: 796956
reactant: 796968
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 796993
fast: false
name: ocosatetraenoyl carnitine transport (C22:4Crn, n6)
product: 796981

797054
type: LocalParameter
value: 0.0

797042
type: LocalParameter
value: 0.0

797030
type: LocalParameter
value: 1000.0

797018
type: LocalParameter
value: -1000.0

796956
type: SpeciesReference
stoichiometry: 1.0
species: 768678

796968
type: SpeciesReference
stoichiometry: 1.0
species: 769863

796993
type: SpeciesReference
stoichiometry: 1.0
species: 770889

770889
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: ocosatetraenoyl carnitine (C22:4Crn, n-6)

796981
type: SpeciesReference
stoichiometry: 1.0
species: 766628

770093
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosenoyl carnitine (C20:1Crn, n9)

769585
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-3-Methyl-2-oxopentanoate

846577
type: Reaction
fast: false
product: 846625
name: phosphomevalonate kinase, reversible, peroxisome
kinetic law: 846637
reactant: 846589
reversible: true
reactant: 846601
product: 846613
notes: GENE_ASSOCIATION: NM_006556.2 GENE_LIST: NM_006556.2 SUBSYSTEM: Cholesterol Metabolism

846625
type: SpeciesReference
stoichiometry: 1.0
species: 771648

846685
type: LocalParameter
value: 0.0

846673
type: LocalParameter
value: 0.0

846661
type: LocalParameter
value: 1000.0

846649
type: LocalParameter
value: -1000.0

846589
type: SpeciesReference
stoichiometry: 1.0
species: 771636

771636
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: (R)-5-Phosphomevalonate

846601
type: SpeciesReference
stoichiometry: 1.0
species: 771660

846613
type: SpeciesReference
stoichiometry: 1.0
species: 771624

765816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: tetradecenoate (C14:1, n-5)

769452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-2-Amino-3-oxobutanoate

778778
type: Reaction
kinetic law: 778814
product: 778802
reactant: 778790
fast: false
reversible: true
name: tetradecenoate (C14:1, n-5) exchange

778863
type: LocalParameter
value: 500.0

778851
type: LocalParameter
value: 0.0

778839
type: LocalParameter
value: 1000.0

778826
type: LocalParameter
value: 0.0

778802
type: SpeciesReference
stoichiometry: 1.0
species: 772527

778790
type: SpeciesReference
stoichiometry: 1.0
species: 765816

769959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosahexaenoyl carnitine (C22:6Crn, n-3)

765768
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Sulfite

791249
type: Reaction
reactant: 791273
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
fast: false
kinetic law: 791309
product: 791297
name: carnitine docosahexaenoyltransferase (C22:6Crn, n3), mitochondrial
product: 791285
reactant: 791261

791273
type: SpeciesReference
stoichiometry: 1.0
species: 769947

769947
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosahexaenoyl-CoA (C22:6CoA, n-3)

791357
type: LocalParameter
value: 0.0

791345
type: LocalParameter
value: 0.0

791333
type: LocalParameter
value: 1000.0

791321
type: LocalParameter
value: -1000.0

791297
type: SpeciesReference
stoichiometry: 1.0
species: 769959

791285
type: SpeciesReference
stoichiometry: 1.0
species: 769851

791261
type: SpeciesReference
stoichiometry: 1.0
species: 769863

768130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Lysine

781514
type: Reaction
kinetic law: 781563
product: 781551
reactant: 781539
reactant: 781526
notes: GENE_ASSOCIATION: (NM_012093.2 or NM_000476.1 or NM_152327.1 or NM_174858.1) GENE_LIST: NM_000476.1 NM_012093.2 NM_152327.1 NM_174858.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: adenylate kinase

781611
type: LocalParameter
value: 0.0

781599
type: LocalParameter
value: 0.0

781587
type: LocalParameter
value: 1000.0

781575
type: LocalParameter
value: -1000.0

781551
type: SpeciesReference
stoichiometry: 2.0
species: 766240

781539
type: SpeciesReference
stoichiometry: 1.0
species: 766398

781526
type: SpeciesReference
stoichiometry: 1.0
species: 766338

814944
type: Reaction
product: 815029
fast: false
product: 815053
kinetic law: 815065
reversible: false
name: Beta oxidation of fatty acid
reactant: 815005
reactant: 814981
reactant: 814993
reactant: 814956
reactant: 814968
product: 815017
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 ... GENE_LIST: NM_000018.2 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_001919.2 NM_001919.2... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 815041

815029
type: SpeciesReference
stoichiometry: 7.0
species: 770165

815053
type: SpeciesReference
stoichiometry: 8.0
species: 770634

815113
type: LocalParameter
value: 500.0

815101
type: LocalParameter
value: 0.0

815089
type: LocalParameter
value: 1000.0

815077
type: LocalParameter
value: 0.0

815005
type: SpeciesReference
stoichiometry: 1.0
species: 770817

814981
type: SpeciesReference
stoichiometry: 8.0
species: 770345

814993
type: SpeciesReference
stoichiometry: 8.0
species: 770622

814956
type: SpeciesReference
stoichiometry: 8.0
species: 769851

814968
type: SpeciesReference
stoichiometry: 7.0
species: 770153

815017
type: SpeciesReference
stoichiometry: 9.0
species: 769657

815041
type: SpeciesReference
stoichiometry: 8.0
species: 770333

774814
type: Reaction
kinetic law: 774850
product: 774838
reactant: 774826
fast: false
reversible: true
name: Ethanol exchange

774898
type: LocalParameter
value: 500.0

774886
type: LocalParameter
value: 0.0

774874
type: LocalParameter
value: 1000.0

774862
type: LocalParameter
value: 0.0

774838
type: SpeciesReference
stoichiometry: 1.0
species: 772032

772032
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: etoh_b

774826
type: SpeciesReference
stoichiometry: 1.0
species: 765321

765321
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Ethanol

768581
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoyl-CoA (C18:1CoA, n-9)

766119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 6-Pyruvoyl-5,6,7,8-tetrahydropterin

814580
type: Reaction
kinetic law: 814702
reversible: false
reactant: 814618
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_014049.3 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or ... GENE_LIST: ... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 814678
product: 814666
product: 814654
fast: false
product: 814690
reactant: 814630
name: Beta oxidation of fatty acid
reactant: 814642
reactant: 814592
reactant: 814605

814750
type: LocalParameter
value: 500.0

814738
type: LocalParameter
value: 0.0

814726
type: LocalParameter
value: 1000.0

814714
type: LocalParameter
value: 0.0

814618
type: SpeciesReference
stoichiometry: 8.0
species: 770345

814678
type: SpeciesReference
stoichiometry: 8.0
species: 770333

814666
type: SpeciesReference
stoichiometry: 7.0
species: 770165

814654
type: SpeciesReference
stoichiometry: 9.0
species: 769657

814690
type: SpeciesReference
stoichiometry: 8.0
species: 770634

814630
type: SpeciesReference
stoichiometry: 8.0
species: 770622

814642
type: SpeciesReference
stoichiometry: 1.0
species: 770792

770792
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl-CoA (C18:1CoA, n-5)

814592
type: SpeciesReference
stoichiometry: 8.0
species: 769851

814605
type: SpeciesReference
stoichiometry: 7.0
species: 770153

845039
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (NM_138733.2 or NM_000291.2) GENE_LIST: NM_000291.2 NM_138733.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 845052
reactant: 845064
kinetic law: 845101
fast: false
name: phosphoglycerate kinase
product: 845088
product: 845076

845052
type: SpeciesReference
stoichiometry: 1.0
species: 765876

765876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Phospho-D-glyceroyl phosphate

845064
type: SpeciesReference
stoichiometry: 1.0
species: 766240

845149
type: LocalParameter
value: 0.0

845137
type: LocalParameter
value: 0.0

845125
type: LocalParameter
value: 1000.0

845113
type: LocalParameter
value: -1000.0

845088
type: SpeciesReference
stoichiometry: 1.0
species: 766398

845076
type: SpeciesReference
stoichiometry: 1.0
species: 765974

816403
type: Reaction
product: 816500
reactant: 816427
product: 816488
reactant: 816464
product: 816476
fast: false
reversible: false
name: Beta oxidation of fatty acid
reactant: 816415
kinetic law: 816524
product: 816512
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_014049.3 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_0... GENE_LIST: NM_0... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 816439
reactant: 816452

816500
type: SpeciesReference
stoichiometry: 9.0
species: 770333

816427
type: SpeciesReference
stoichiometry: 1.0
species: 770129

770129
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosatetraenoyl-CoA (C20:4CoA, n-6)

816488
type: SpeciesReference
stoichiometry: 5.0
species: 770165

816464
type: SpeciesReference
stoichiometry: 9.0
species: 770622

816476
type: SpeciesReference
stoichiometry: 10.0
species: 769657

816415
type: SpeciesReference
stoichiometry: 9.0
species: 769851

816573
type: LocalParameter
value: 500.0

816560
type: LocalParameter
value: 0.0

816548
type: LocalParameter
value: 1000.0

816536
type: LocalParameter
value: 0.0

816512
type: SpeciesReference
stoichiometry: 9.0
species: 770634

816439
type: SpeciesReference
stoichiometry: 5.0
species: 770153

816452
type: SpeciesReference
stoichiometry: 9.0
species: 770345

770877
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: ocosatetraenoyl-CoA (C22:4CoA, n-6)

783974
type: Reaction
reactant: 783986
kinetic law: 784047
product: 784035
reactant: 783998
reversible: false
product: 784023
name: alcohol dehydrogenase (ethanol, NADP), forward reaction
fast: false
notes: GENE_ASSOCIATION: (NM_153326.1 or NM_006066.2) GENE_LIST: NM_006066.2 NM_153326.1 SUBSYSTEM: Cholesterol Metabolism
product: 784011

783986
type: SpeciesReference
stoichiometry: 1.0
species: 767331

767331
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Ethanol

784095
type: LocalParameter
value: 500.0

784083
type: LocalParameter
value: 0.0

784071
type: LocalParameter
value: 1000.0

784059
type: LocalParameter
value: 0.0

784035
type: SpeciesReference
stoichiometry: 1.0
species: 768335

783998
type: SpeciesReference
stoichiometry: 1.0
species: 768323

784023
type: SpeciesReference
stoichiometry: 1.0
species: 767767

784011
type: SpeciesReference
stoichiometry: 1.0
species: 766192

766192
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetaldehyde

844270
type: Reaction
name: pyruvate dehydrogenase, mitochondrial
reactant: 844306
reversible: false
product: 844330
kinetic law: 844354
reactant: 844294
notes: GENE_ASSOCIATION: ((NM_001931.2 and (NM_000108.3 and NM_003477.1) and (NM_000925.1 and NM_005390.3)) or (NM_001931.2 and (NM_000108.3 and NM_003477.1) and (NM_000284.1 and NM_000925.1))) GENE_LIST: NM_000108.3 NM_000284.1 NM_000925.1 NM_001931.2 NM_003477.1 NM_005390.3 SUBSYSTEM: Citrate Cycle (TCA)
product: 844342
fast: false
reactant: 844282
product: 844318

844306
type: SpeciesReference
stoichiometry: 1.0
species: 771070

844330
type: SpeciesReference
stoichiometry: 1.0
species: 769839

844402
type: LocalParameter
value: 500.0

844390
type: LocalParameter
value: 0.0

844378
type: LocalParameter
value: 1000.0

844366
type: LocalParameter
value: 0.0

844294
type: SpeciesReference
stoichiometry: 1.0
species: 770622

844342
type: SpeciesReference
stoichiometry: 1.0
species: 770634

844282
type: SpeciesReference
stoichiometry: 1.0
species: 769851

844318
type: SpeciesReference
stoichiometry: 1.0
species: 769657

772250
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: leu_L_b

767380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Fructose 2,6-bisphosphate

847073
type: Reaction
product: 847121
kinetic law: 847145
product: 847109
name: inorganic triphosphatase
product: 847133
reversible: false
fast: false
notes: SUBSYSTEM: Other
reactant: 847085
reactant: 847097

847121
type: SpeciesReference
stoichiometry: 1.0
species: 768800

847193
type: LocalParameter
value: 500.0

847181
type: LocalParameter
value: 0.0

847169
type: LocalParameter
value: 1000.0

847157
type: LocalParameter
value: 0.0

847109
type: SpeciesReference
stoichiometry: 1.0
species: 767767

847133
type: SpeciesReference
stoichiometry: 1.0
species: 768885

847085
type: SpeciesReference
stoichiometry: 1.0
species: 767779

847097
type: SpeciesReference
stoichiometry: 1.0
species: 768897

768897
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Inorganic triphosphate

770744
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecadienoyl-CoA (C18:2CoA, n-6)

826626
type: Reaction
notes: GENE_ASSOCIATION: (NM_014905.2 or NM_013267.2) GENE_LIST: NM_013267.2 NM_014905.2 SUBSYSTEM: Glutamate Metabolism
name: glutaminase, mitochondrial
fast: false
product: 826664
product: 826676
reversible: false
kinetic law: 826688
reactant: 826638
reactant: 826651

826664
type: SpeciesReference
stoichiometry: 1.0
species: 770261

826676
type: SpeciesReference
stoichiometry: 1.0
species: 770671

826737
type: LocalParameter
value: 500.0

826725
type: LocalParameter
value: 0.0

826712
type: LocalParameter
value: 1000.0

826700
type: LocalParameter
value: 0.0

826638
type: SpeciesReference
stoichiometry: 1.0
species: 770249

826651
type: SpeciesReference
stoichiometry: 1.0
species: 770345

765491
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: heptadecanoate (C17:0)

770997
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Palmitoyl-CoA (n-C16:0CoA)

765998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Sulfino-L-alanine

844546
type: Reaction
product: 844595
product: 844607
product: 844582
kinetic law: 844619
fast: false
reversible: false
reactant: 844558
name: 6-phosphofructo-2-kinase
notes: GENE_ASSOCIATION: (NM_002625.1 or NM_004567.2 or NM_004566.2 or NM_001018053.1 or NM_006212.2) GENE_LIST: NM_001018053.1 NM_002625.1 NM_004566.2 NM_004567.2 NM_006212.2 SUBSYSTEM: Fructose and Mannose Metabolism
reactant: 844570

844595
type: SpeciesReference
stoichiometry: 1.0
species: 767380

844607
type: SpeciesReference
stoichiometry: 1.0
species: 767767

844582
type: SpeciesReference
stoichiometry: 1.0
species: 766240

844667
type: LocalParameter
value: 500.0

844655
type: LocalParameter
value: 0.0

844643
type: LocalParameter
value: 1000.0

844631
type: LocalParameter
value: 0.0

844558
type: SpeciesReference
stoichiometry: 1.0
species: 766398

844570
type: SpeciesReference
stoichiometry: 1.0
species: 767392

767392
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Fructose 6-phosphate

771720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: H+

789764
type: Reaction
product: 789836
fast: false
notes: GENE_ASSOCIATION: NM_005984.1 GENE_LIST: NM_005984.1 SUBSYSTEM: Transport, Mitochondrial
reactant: 789776
product: 789812
reactant: 789800
name: citrate transport, mitochondrial
product: 789824
reactant: 789788
kinetic law: 789848
reversible: true

789836
type: SpeciesReference
stoichiometry: 1.0
species: 770333

789776
type: SpeciesReference
stoichiometry: 1.0
species: 766556

766556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Citrate

789812
type: SpeciesReference
stoichiometry: 1.0
species: 768142

789800
type: SpeciesReference
stoichiometry: 1.0
species: 770538

789824
type: SpeciesReference
stoichiometry: 1.0
species: 769790

789788
type: SpeciesReference
stoichiometry: 1.0
species: 767767

789897
type: LocalParameter
value: 0.0

789884
type: LocalParameter
value: 0.0

789872
type: LocalParameter
value: 1000.0

789860
type: LocalParameter
value: -1000.0

837612
type: Reaction
kinetic law: 837648
product: 837636
reactant: 837624
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: (S)-Methylmalonate semialdehyde transport, mitochondrial

837696
type: LocalParameter
value: 0.0

837684
type: LocalParameter
value: 0.0

837672
type: LocalParameter
value: 1000.0

837660
type: LocalParameter
value: -1000.0

837636
type: SpeciesReference
stoichiometry: 1.0
species: 768262

837624
type: SpeciesReference
stoichiometry: 1.0
species: 770586

767241
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoyl-CoA (C20:1CoA, n-11)

771840
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ala_L_b

765225
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: docosahexaenoate (C22:6, n-3)

822817
type: Reaction
product: 822853
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
product: 822865
name: fumarate transport, mitochondrial
fast: false
reversible: true
reactant: 822829
reactant: 822841
kinetic law: 822877

822853
type: SpeciesReference
stoichiometry: 1.0
species: 768800

822865
type: SpeciesReference
stoichiometry: 1.0
species: 770225

770225
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Fumarate

822829
type: SpeciesReference
stoichiometry: 1.0
species: 767537

822841
type: SpeciesReference
stoichiometry: 1.0
species: 770985

822926
type: LocalParameter
value: 0.0

822914
type: LocalParameter
value: 0.0

822902
type: LocalParameter
value: 1000.0

822889
type: LocalParameter
value: -1000.0

772238
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: lac_L_b

765527
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Lactate

782072
type: Reaction
kinetic law: 782120
product: 782108
product: 782096
reactant: 782084
notes: GENE_ASSOCIATION: NM_000026.1 GENE_LIST: NM_000026.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: adenylsuccinate lyase

782168
type: LocalParameter
value: 0.0

782156
type: LocalParameter
value: 0.0

782144
type: LocalParameter
value: 1000.0

782132
type: LocalParameter
value: -1000.0

782108
type: SpeciesReference
stoichiometry: 1.0
species: 767537

782096
type: SpeciesReference
stoichiometry: 1.0
species: 766338

782084
type: SpeciesReference
stoichiometry: 1.0
species: 766712

766712
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N6-(1,2-Dicarboxyethyl)-AMP

765720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: (R)-Pantothenate

821984
type: Reaction
kinetic law: 822020
product: 822008
reactant: 821996
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: formate transport via diffusion

822068
type: LocalParameter
value: 0.0

822056
type: LocalParameter
value: 0.0

822044
type: LocalParameter
value: 1000.0

822032
type: LocalParameter
value: -1000.0

822008
type: SpeciesReference
stoichiometry: 1.0
species: 771396

821996
type: SpeciesReference
stoichiometry: 1.0
species: 767488

767488
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Formate

814388
type: Reaction
reactant: 814400
fast: false
reversible: false
reactant: 814412
product: 814508
product: 814496
product: 814472
reactant: 814424
name: Beta oxidation of long chain fatty acid
product: 814484
product: 814460
reactant: 814436
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_004092.2 and NM_001037811.2) or (NM_001033859.1 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2... GENE_LIST: NM_000018.2 NM_000018.2... NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 814448
kinetic law: 814520

814400
type: SpeciesReference
stoichiometry: 1.0
species: 769851

814412
type: SpeciesReference
stoichiometry: 1.0
species: 770153

814508
type: SpeciesReference
stoichiometry: 1.0
species: 770997

814496
type: SpeciesReference
stoichiometry: 1.0
species: 770634

814472
type: SpeciesReference
stoichiometry: 1.0
species: 770165

814424
type: SpeciesReference
stoichiometry: 1.0
species: 770345

814484
type: SpeciesReference
stoichiometry: 1.0
species: 770333

814460
type: SpeciesReference
stoichiometry: 1.0
species: 769657

814436
type: SpeciesReference
stoichiometry: 1.0
species: 770622

814448
type: SpeciesReference
stoichiometry: 1.0
species: 771095

814568
type: LocalParameter
value: 500.0

814556
type: LocalParameter
value: 0.0

814544
type: LocalParameter
value: 1000.0

814532
type: LocalParameter
value: 0.0

798155
type: Reaction
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 798215
reversible: true
reactant: 798179
product: 798191
name: carnitine palmitoyltransferase (C16:0Crn), mitochondrial
reactant: 798167
product: 798203
fast: false

798264
type: LocalParameter
value: 0.0

798252
type: LocalParameter
value: 0.0

798240
type: LocalParameter
value: 1000.0

798227
type: LocalParameter
value: -1000.0

798179
type: SpeciesReference
stoichiometry: 1.0
species: 771009

771009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Palmitoylcarnitine (C16:0Crn)

798191
type: SpeciesReference
stoichiometry: 1.0
species: 769863

798167
type: SpeciesReference
stoichiometry: 1.0
species: 769851

798203
type: SpeciesReference
stoichiometry: 1.0
species: 770997

769911
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: dodecanoylcarnitine (C12:0Crn)

771119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Succinate

766168
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetate

766204
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetyl-CoA

853082
type: Reaction
reversible: true
reactant: 853107
reactant: 853094
product: 853132
name: succinate dehydrogenase
notes: GENE_ASSOCIATION: ((NM_003000.1 and NM_003001.3 and NM_003002.1 and NM_004168.1) or (NM_001035513.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_001035512.1 and NM_003000.1 and NM_003002.1 and NM_004168.1) or (NM_001035511.1 and NM_003000.1 and NM_003002.1 and NM_004168.1)) GENE_LIST: NM_001035511.1 NM_001035512.1 NM_001035513.1 NM_003000.1 NM_003001.3 NM_003002.1 NM_004168.1 SUBSYSTEM: Citrate Cycle (TCA)
product: 853120
fast: false
kinetic law: 853145

853107
type: SpeciesReference
stoichiometry: 1.0
species: 771216

771216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Ubiquinone-10

853094
type: SpeciesReference
stoichiometry: 1.0
species: 771119

853132
type: SpeciesReference
stoichiometry: 1.0
species: 771082

853120
type: SpeciesReference
stoichiometry: 1.0
species: 770225

853194
type: LocalParameter
value: 0.0

853182
type: LocalParameter
value: 0.0

853170
type: LocalParameter
value: 1000.0

853158
type: LocalParameter
value: -1000.0

795849
type: Reaction
product: 795885
reversible: true
kinetic law: 795909
reactant: 795861
fast: false
reactant: 795873
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
name: octadecenoyl carnitine transport (C18:1Crn, n9)
product: 795897

795885
type: SpeciesReference
stoichiometry: 1.0
species: 766628

795957
type: LocalParameter
value: 0.0

795945
type: LocalParameter
value: 0.0

795933
type: LocalParameter
value: 1000.0

795921
type: LocalParameter
value: -1000.0

795861
type: SpeciesReference
stoichiometry: 1.0
species: 768618

768618
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoyl carnitine (C18:1Crn, n9)

795873
type: SpeciesReference
stoichiometry: 1.0
species: 769863

795897
type: SpeciesReference
stoichiometry: 1.0
species: 770853

781274
type: Reaction
reactant: 781286
fast: false
reactant: 781298
name: acetate mitochondrial transport via proton symport
kinetic law: 781334
reversible: true
product: 781322
product: 781310
notes: SUBSYSTEM: Transport, Mitochondrial

781286
type: SpeciesReference
stoichiometry: 1.0
species: 766168

781298
type: SpeciesReference
stoichiometry: 1.0
species: 767767

781382
type: LocalParameter
value: 0.0

781370
type: LocalParameter
value: 0.0

781358
type: LocalParameter
value: 1000.0

781346
type: LocalParameter
value: -1000.0

781322
type: SpeciesReference
stoichiometry: 1.0
species: 770333

781310
type: SpeciesReference
stoichiometry: 1.0
species: 769633

769633
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Acetate

768034
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: IDP

842079
type: Reaction
kinetic law: 842116
product: 842103
reactant: 842091
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: octadecenoate (C18:1, n-7) transport

842164
type: LocalParameter
value: 0.0

842152
type: LocalParameter
value: 0.0

842140
type: LocalParameter
value: 1000.0

842128
type: LocalParameter
value: -1000.0

842103
type: SpeciesReference
stoichiometry: 1.0
species: 765635

765635
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecenoate (C18:1, n-7)

842091
type: SpeciesReference
stoichiometry: 1.0
species: 768421

769343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: UDPglucose

827865
type: Reaction
notes: GENE_ASSOCIATION: (NM_001077484.1 or NM_007231.1 or NM_018018.2 or NM_030674.2 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
reversible: true
name: glycine reversible transport via sodium symport, blood
reactant: 827889
fast: false
reactant: 827877
kinetic law: 827925
product: 827901
product: 827913

827889
type: SpeciesReference
stoichiometry: 1.0
species: 765575

827877
type: SpeciesReference
stoichiometry: 1.0
species: 765382

827973
type: LocalParameter
value: 0.0

827961
type: LocalParameter
value: 0.0

827949
type: LocalParameter
value: 1000.0

827937
type: LocalParameter
value: -1000.0

827901
type: SpeciesReference
stoichiometry: 1.0
species: 767658

767658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Glycine

827913
type: SpeciesReference
stoichiometry: 1.0
species: 768286

847447
type: Reaction
reversible: false
product: 847484
notes: GENE_ASSOCIATION: NM_021823.3 GENE_LIST: NM_021823.3 SUBSYSTEM: CoA Biosynthesis
product: 847496
reactant: 847459
kinetic law: 847508
reactant: 847471
name: phosphopantothenoylcysteine decarboxylase
fast: false

847484
type: SpeciesReference
stoichiometry: 1.0
species: 766604

847496
type: SpeciesReference
stoichiometry: 1.0
species: 768702

768702
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Pantetheine 4'-phosphate

847459
type: SpeciesReference
stoichiometry: 1.0
species: 766046

766046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

847557
type: LocalParameter
value: 500.0

847545
type: LocalParameter
value: 0.0

847532
type: LocalParameter
value: 1000.0

847520
type: LocalParameter
value: 0.0

847471
type: SpeciesReference
stoichiometry: 1.0
species: 767767

768021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Isocitrate

808669
type: Reaction
notes: GENE_ASSOCIATION: (NM_203380.1 or NM_004457.3 or NM_022977.1 or NM_001995.2 or NM_203372.1 or NM_001995.2 or NM_016234.3 or NM_004458.1 or NM_203379.1) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reversible: true
reactant: 808693
name: fatty-acid--CoA ligase (octadecenoate, C18:1 n-5)
product: 808729
reactant: 808681
product: 808717
kinetic law: 808753
product: 808741
reactant: 808705
fast: false

808693
type: SpeciesReference
stoichiometry: 1.0
species: 766616

808729
type: SpeciesReference
stoichiometry: 1.0
species: 768556

808681
type: SpeciesReference
stoichiometry: 1.0
species: 766398

808717
type: SpeciesReference
stoichiometry: 1.0
species: 766338

808801
type: LocalParameter
value: 0.0

808789
type: LocalParameter
value: 0.0

808777
type: LocalParameter
value: 1000.0

808765
type: LocalParameter
value: -1000.0

808741
type: SpeciesReference
stoichiometry: 1.0
species: 768885

808705
type: SpeciesReference
stoichiometry: 1.0
species: 768409

769210
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Threonine

851989
type: Reaction
reactant: 852013
notes: SUBSYSTEM: ROS Detoxification
fast: false
product: 852026
kinetic law: 852050
reversible: false
product: 852038
reactant: 852001
name: superoxide dismutase, peroxisome

852013
type: SpeciesReference
stoichiometry: 2.0
species: 771792

771792
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Superoxide

852026
type: SpeciesReference
stoichiometry: 1.0
species: 771744

852099
type: LocalParameter
value: 500.0

852087
type: LocalParameter
value: 0.0

852074
type: LocalParameter
value: 1000.0

852062
type: LocalParameter
value: 0.0

852038
type: SpeciesReference
stoichiometry: 1.0
species: 771780

852001
type: SpeciesReference
stoichiometry: 2.0
species: 771720

829125
type: Reaction
kinetic law: 829161
product: 829149
reactant: 829137
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: hydrogen peroxide mitochondrial transport

829209
type: LocalParameter
value: 0.0

829197
type: LocalParameter
value: 0.0

829185
type: LocalParameter
value: 1000.0

829173
type: LocalParameter
value: -1000.0

829149
type: SpeciesReference
stoichiometry: 1.0
species: 770357

770357
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Hydrogen peroxide

829137
type: SpeciesReference
stoichiometry: 1.0
species: 767791

779776
type: Reaction
kinetic law: 779824
product: 779812
product: 779800
reactant: 779788
notes: GENE_ASSOCIATION: (NM_000019.2 or (NM_000182.3 and NM_000183.1)) GENE_LIST: NM_000019.2 NM_000182.3 NM_000183.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: true
name: acetyl-CoA C-acetyltransferase, mitochondrial

779872
type: LocalParameter
value: 0.0

779860
type: LocalParameter
value: 0.0

779848
type: LocalParameter
value: 1000.0

779836
type: LocalParameter
value: -1000.0

779812
type: SpeciesReference
stoichiometry: 1.0
species: 769851

779800
type: SpeciesReference
stoichiometry: 1.0
species: 769609

769609
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Acetoacetyl-CoA

779788
type: SpeciesReference
stoichiometry: 2.0
species: 769657

770297
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Glycine

805332
type: Reaction
reactant: 805344
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Nucleotide Metabolism
reactant: 805356
name: dihydroorotase
reversible: true
kinetic law: 805392
product: 805380
fast: false
product: 805368

805344
type: SpeciesReference
stoichiometry: 1.0
species: 766932

766932
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (S)-Dihydroorotate

805356
type: SpeciesReference
stoichiometry: 1.0
species: 767779

805440
type: LocalParameter
value: 0.0

805428
type: LocalParameter
value: 0.0

805416
type: LocalParameter
value: 1000.0

805404
type: LocalParameter
value: -1000.0

805380
type: SpeciesReference
stoichiometry: 1.0
species: 767767

805368
type: SpeciesReference
stoichiometry: 1.0
species: 766434

768861
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Propionate

834784
type: Reaction
kinetic law: 834820
product: 834808
reactant: 834796
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-lysine transport via diffusion, blood

834868
type: LocalParameter
value: 0.0

834856
type: LocalParameter
value: 0.0

834844
type: LocalParameter
value: 1000.0

834832
type: LocalParameter
value: -1000.0

834808
type: SpeciesReference
stoichiometry: 1.0
species: 768130

834796
type: SpeciesReference
stoichiometry: 1.0
species: 765551

765551
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Lysine

851505
type: Reaction
reactant: 851529
name: L-serine via sodium symport, blood
product: 851541
reactant: 851517
reversible: true
product: 851553
fast: false
notes: GENE_ASSOCIATION: (NM_018018.2 or NM_007231.1 or NM_030674.2 or NM_001077484.1 or NM_018976.3) GENE_LIST: NM_001077484.1 NM_007231.1 NM_018018.2 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
kinetic law: 851565

851529
type: SpeciesReference
stoichiometry: 1.0
species: 765756

765756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Serine

851541
type: SpeciesReference
stoichiometry: 1.0
species: 768286

851517
type: SpeciesReference
stoichiometry: 1.0
species: 765575

851553
type: SpeciesReference
stoichiometry: 1.0
species: 769041

851614
type: LocalParameter
value: 0.0

851602
type: LocalParameter
value: 0.0

851589
type: LocalParameter
value: 1000.0

851577
type: LocalParameter
value: -1000.0

772116
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: h2o_b

803554
type: Reaction
kinetic law: 803650
reactant: 803590
reactant: 803566
product: 803638
fast: false
reactant: 803602
product: 803626
notes: GENE_ASSOCIATION: (NM_004265.2 or NM_021727.3) GENE_LIST: NM_004265.2 NM_021727.3 SUBSYSTEM: Fatty Acid Synthesis
name: Oleoyl-CoA desaturase (C18:2CoA, n6 -> C18:3CoA, n6)
product: 803614
reactant: 803578
reversible: false

803698
type: LocalParameter
value: 500.0

803686
type: LocalParameter
value: 0.0

803674
type: LocalParameter
value: 1000.0

803662
type: LocalParameter
value: 0.0

803590
type: SpeciesReference
stoichiometry: 1.0
species: 768359

803566
type: SpeciesReference
stoichiometry: 1.0
species: 767767

803638
type: SpeciesReference
stoichiometry: 1.0
species: 768532

768532
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecatrienoyl-CoA (C18:3CoA, n-6)

803602
type: SpeciesReference
stoichiometry: 1.0
species: 768470

803626
type: SpeciesReference
stoichiometry: 1.0
species: 768323

803614
type: SpeciesReference
stoichiometry: 2.0
species: 767779

803578
type: SpeciesReference
stoichiometry: 1.0
species: 768335

814206
type: Reaction
reversible: false
kinetic law: 814327
fast: false
product: 814279
product: 814291
reactant: 814266
reactant: 814254
product: 814303
reactant: 814218
name: Beta oxidation of fatty acid
reactant: 814242
reactant: 814230
product: 814315
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_001608.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_00409... GENE_LIST: NM_000016.2 NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919.2 NM_00409... NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation

814376
type: LocalParameter
value: 500.0

814364
type: LocalParameter
value: 0.0

814351
type: LocalParameter
value: 1000.0

814339
type: LocalParameter
value: 0.0

814279
type: SpeciesReference
stoichiometry: 8.0
species: 769657

814291
type: SpeciesReference
stoichiometry: 6.0
species: 770165

814266
type: SpeciesReference
stoichiometry: 7.0
species: 770622

814254
type: SpeciesReference
stoichiometry: 1.0
species: 770393

770393
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: hexadecenoyl-CoA (C16:1CoA, n-9)

814303
type: SpeciesReference
stoichiometry: 7.0
species: 770333

814218
type: SpeciesReference
stoichiometry: 7.0
species: 769851

814242
type: SpeciesReference
stoichiometry: 7.0
species: 770345

814230
type: SpeciesReference
stoichiometry: 6.0
species: 770153

814315
type: SpeciesReference
stoichiometry: 7.0
species: 770634

793066
type: Reaction
reactant: 793078
product: 793114
fast: false
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_152247.1 or NM_152245.1 or NM_001876.2 or NM_001031847.1 or NM_004377.2 or NM_152359.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reversible: true
product: 793102
kinetic law: 793126
reactant: 793090
name: carnitine eicosatetraenoyltransferase (C20:4Crn, n6)

793078
type: SpeciesReference
stoichiometry: 1.0
species: 766628

793114
type: SpeciesReference
stoichiometry: 1.0
species: 767367

767367
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatetraenoyl carnitine (C20:4Crn, n-6)

793102
type: SpeciesReference
stoichiometry: 1.0
species: 766616

793174
type: LocalParameter
value: 0.0

793162
type: LocalParameter
value: 0.0

793150
type: LocalParameter
value: 1000.0

793138
type: LocalParameter
value: -1000.0

793090
type: SpeciesReference
stoichiometry: 1.0
species: 767355

793549
type: Reaction
product: 793597
reactant: 793573
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 793610
reversible: true
product: 793585
reactant: 793561
name: carnitine eicosatrienoyltransferase (C20:3Crn, n6), mitochondrial

793597
type: SpeciesReference
stoichiometry: 1.0
species: 770117

793573
type: SpeciesReference
stoichiometry: 1.0
species: 770105

770105
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosatrienoyl-CoA (C20:3CoA, n-6)

793659
type: LocalParameter
value: 0.0

793647
type: LocalParameter
value: 0.0

793635
type: LocalParameter
value: 1000.0

793622
type: LocalParameter
value: -1000.0

793585
type: SpeciesReference
stoichiometry: 1.0
species: 769851

793561
type: SpeciesReference
stoichiometry: 1.0
species: 769863

768630
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Ornithine

769440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 1-Pyrroline-5-carboxylate

768726
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: propionyl-carnitine

775201
type: Reaction
kinetic law: 775237
product: 775225
reactant: 775213
fast: false
reversible: true
name: L-Glutamate exchange

775285
type: LocalParameter
value: 500.0

775273
type: LocalParameter
value: 0.0

775261
type: LocalParameter
value: 1000.0

775249
type: LocalParameter
value: 0.0

775225
type: SpeciesReference
stoichiometry: 1.0
species: 772080

772080
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: glu_L_b

775213
type: SpeciesReference
stoichiometry: 1.0
species: 765369

765369
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Glutamate

778875
type: Reaction
kinetic law: 778911
product: 778899
reactant: 778887
fast: false
reversible: true
name: L-Tyrosine exchange

778963
type: LocalParameter
value: 500.0

778950
type: LocalParameter
value: 0.0

778937
type: LocalParameter
value: 1000.0

778924
type: LocalParameter
value: 0.0

778899
type: SpeciesReference
stoichiometry: 1.0
species: 772540

778887
type: SpeciesReference
stoichiometry: 1.0
species: 765828

767695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: glycogen

771612
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Zymostenol

771900
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: co2_b

767609
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Glucose

791852
type: Reaction
product: 791888
product: 791900
reactant: 791876
name: dodecanoyl carnitine transport (C12:0Crn)
reversible: true
reactant: 791864
fast: false
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 791912

791888
type: SpeciesReference
stoichiometry: 1.0
species: 766628

791900
type: SpeciesReference
stoichiometry: 1.0
species: 769911

791876
type: SpeciesReference
stoichiometry: 1.0
species: 769863

791864
type: SpeciesReference
stoichiometry: 1.0
species: 766858

766858
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dodecanoylcarnitine (C12:0Crn)

791960
type: LocalParameter
value: 0.0

791948
type: LocalParameter
value: 0.0

791936
type: LocalParameter
value: 1000.0

791924
type: LocalParameter
value: -1000.0

808957
type: Reaction
name: fatty-acid--CoA ligase (octadecenoate, C18:1 n-9)
reversible: true
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_001995.2 or NM_004457.3 or NM_004458.1 or NM_203380.1 or NM_015256.2 or NM_022977.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reactant: 808969
fast: false
product: 809017
kinetic law: 809041
reactant: 808993
product: 809029
product: 809005
reactant: 808981

808969
type: SpeciesReference
stoichiometry: 1.0
species: 766398

809017
type: SpeciesReference
stoichiometry: 1.0
species: 768581

809089
type: LocalParameter
value: 0.0

809077
type: LocalParameter
value: 0.0

809065
type: LocalParameter
value: 1000.0

809053
type: LocalParameter
value: -1000.0

808993
type: SpeciesReference
stoichiometry: 1.0
species: 768433

809029
type: SpeciesReference
stoichiometry: 1.0
species: 768885

809005
type: SpeciesReference
stoichiometry: 1.0
species: 766338

808981
type: SpeciesReference
stoichiometry: 1.0
species: 766616

854826
type: Reaction
product: 854886
reactant: 854850
fast: false
reversible: false
reactant: 854838
notes: GENE_ASSOCIATION: NM_001807.3 GENE_LIST: NM_001807.3 SUBSYSTEM: Triglycerol Degradation
product: 854862
kinetic law: 854898
product: 854874
name: triacylglycerol hydrolase, human myocyte

854886
type: SpeciesReference
stoichiometry: 1.0
species: 767767

854850
type: SpeciesReference
stoichiometry: 0.001
species: 769258

854838
type: SpeciesReference
stoichiometry: 1.0
species: 767779

854862
type: SpeciesReference
stoichiometry: 0.001
species: 765864

854946
type: LocalParameter
value: 500.0

854934
type: LocalParameter
value: 0.0

854922
type: LocalParameter
value: 1000.0

854910
type: LocalParameter
value: 0.0

854874
type: SpeciesReference
stoichiometry: 0.001
species: 767404

767404
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Average fatty acid, human adipocyte

788553
type: Reaction
kinetic law: 788601
product: 788589
reactant: 788577
reactant: 788565
notes: GENE_ASSOCIATION: NM_001801.2 GENE_LIST: NM_001801.2 SUBSYSTEM: Cysteine Metabolism
fast: false
reversible: false
name: cysteine dioxygenase

788650
type: LocalParameter
value: 500.0

788638
type: LocalParameter
value: 0.0

788625
type: LocalParameter
value: 1000.0

788613
type: LocalParameter
value: 0.0

788589
type: SpeciesReference
stoichiometry: 1.0
species: 765998

788577
type: SpeciesReference
stoichiometry: 1.0
species: 768359

788565
type: SpeciesReference
stoichiometry: 1.0
species: 766652

820616
type: Reaction
product: 820724
reversible: false
product: 820772
product: 820808
notes: SUBSYSTEM: Triglycerol Degradation
product: 820869
product: 820784
product: 820820
product: 820845
product: 820700
product: 820760
product: 820688
product: 820905
product: 820857
product: 820664
product: 820917
name: Average fatty acid pseudoabstractase
product: 820676
product: 820881
kinetic law: 820929
product: 820893
product: 820833
product: 820736
product: 820796
reactant: 820628
fast: false
product: 820640
product: 820748
product: 820712
product: 820652

820724
type: SpeciesReference
stoichiometry: 0.007
species: 767177

820772
type: SpeciesReference
stoichiometry: 0.03
species: 767839

820808
type: SpeciesReference
stoichiometry: 0.064
species: 768397

820869
type: SpeciesReference
stoichiometry: 0.159
species: 768458

820784
type: SpeciesReference
stoichiometry: 0.005
species: 767851

820820
type: SpeciesReference
stoichiometry: 0.003
species: 768409

820845
type: SpeciesReference
stoichiometry: 0.393
species: 768433

820700
type: SpeciesReference
stoichiometry: 0.003
species: 767151

820760
type: SpeciesReference
stoichiometry: 0.243
species: 767827

820688
type: SpeciesReference
stoichiometry: 0.002
species: 767112

820905
type: SpeciesReference
stoichiometry: 0.037
species: 769294

820857
type: SpeciesReference
stoichiometry: 0.005
species: 768446

820664
type: SpeciesReference
stoichiometry: 0.002
species: 766809

820917
type: SpeciesReference
stoichiometry: 0.002
species: 769306

820676
type: SpeciesReference
stoichiometry: 0.007
species: 766833

820881
type: SpeciesReference
stoichiometry: 0.002
species: 768495

820977
type: LocalParameter
value: 500.0

820965
type: LocalParameter
value: 0.0

820953
type: LocalParameter
value: 1000.0

820941
type: LocalParameter
value: 0.0

820893
type: SpeciesReference
stoichiometry: 0.003
species: 768969

820833
type: SpeciesReference
stoichiometry: 0.018
species: 768421

820736
type: SpeciesReference
stoichiometry: 0.003
species: 767189

820796
type: SpeciesReference
stoichiometry: 0.003
species: 767972

820628
type: SpeciesReference
stoichiometry: 0.001
species: 767404

820640
type: SpeciesReference
stoichiometry: 0.001
species: 766784

820748
type: SpeciesReference
stoichiometry: 0.004
species: 767202

820712
type: SpeciesReference
stoichiometry: 0.002
species: 767164

820652
type: SpeciesReference
stoichiometry: 0.002
species: 766796

776167
type: Reaction
kinetic law: 776205
product: 776192
reactant: 776179
fast: false
reversible: true
name: heptadecanoate (C17:0) exchange

776254
type: LocalParameter
value: 500.0

776241
type: LocalParameter
value: 0.0

776229
type: LocalParameter
value: 1000.0

776217
type: LocalParameter
value: 0.0

776192
type: SpeciesReference
stoichiometry: 1.0
species: 772202

772202
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: hpdca_b

776179
type: SpeciesReference
stoichiometry: 1.0
species: 765491

780525
type: Reaction
notes: GENE_ASSOCIATION: NM_130767.2 GENE_LIST: NM_130767.2 SUBSYSTEM: Pyruvate Metabolism
product: 780586
fast: false
product: 780574
name: acetyl-CoA hydrolase
product: 780561
reactant: 780537
kinetic law: 780598
reversible: false
reactant: 780549

780586
type: SpeciesReference
stoichiometry: 1.0
species: 767767

780574
type: SpeciesReference
stoichiometry: 1.0
species: 766616

780561
type: SpeciesReference
stoichiometry: 1.0
species: 766168

780537
type: SpeciesReference
stoichiometry: 1.0
species: 766204

780646
type: LocalParameter
value: 500.0

780634
type: LocalParameter
value: 0.0

780622
type: LocalParameter
value: 1000.0

780610
type: LocalParameter
value: 0.0

780549
type: SpeciesReference
stoichiometry: 1.0
species: 767779

815125
type: Reaction
reactant: 815185
reactant: 815149
fast: false
name: Beta oxidation of fatty acid
product: 815209
reactant: 815173
reactant: 815137
kinetic law: 815246
product: 815234
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and ... GENE_LIST: ... NM_000018.2 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 815161
product: 815221
product: 815197
reversible: false

815185
type: SpeciesReference
stoichiometry: 1.0
species: 770744

815149
type: SpeciesReference
stoichiometry: 6.0
species: 770153

815209
type: SpeciesReference
stoichiometry: 6.0
species: 770165

815173
type: SpeciesReference
stoichiometry: 8.0
species: 770622

815137
type: SpeciesReference
stoichiometry: 8.0
species: 769851

815294
type: LocalParameter
value: 500.0

815282
type: LocalParameter
value: 0.0

815270
type: LocalParameter
value: 1000.0

815258
type: LocalParameter
value: 0.0

815234
type: SpeciesReference
stoichiometry: 8.0
species: 770634

815161
type: SpeciesReference
stoichiometry: 8.0
species: 770345

815221
type: SpeciesReference
stoichiometry: 8.0
species: 770333

815197
type: SpeciesReference
stoichiometry: 9.0
species: 769657

770683
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: nonanoyl-CoA (C9:0CoA)

790433
type: Reaction
kinetic law: 790469
product: 790457
reactant: 790445
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: CO2 peroxisomal transport

790517
type: LocalParameter
value: 0.0

790505
type: LocalParameter
value: 0.0

790493
type: LocalParameter
value: 1000.0

790481
type: LocalParameter
value: -1000.0

790457
type: SpeciesReference
stoichiometry: 1.0
species: 771672

790445
type: SpeciesReference
stoichiometry: 1.0
species: 766604

839314
type: Reaction
product: 839350
reversible: true
fast: false
notes: GENE_ASSOCIATION: (NM_003048.3 or NM_001011552.1 or NM_004174.1 or NM_004594.1 or NM_173653.1 or NM_003047.2) GENE_LIST: NM_001011552.1 NM_003047.2 NM_003048.3 NM_004174.1 NM_004594.1 NM_173653.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 839374
product: 839362
reactant: 839326
reactant: 839338
name: sodium transport in/out via proton antiport (one H+), blood

839350
type: SpeciesReference
stoichiometry: 1.0
species: 765575

839423
type: LocalParameter
value: 0.0

839410
type: LocalParameter
value: 0.0

839398
type: LocalParameter
value: 1000.0

839386
type: LocalParameter
value: -1000.0

839362
type: SpeciesReference
stoichiometry: 1.0
species: 767767

839326
type: SpeciesReference
stoichiometry: 1.0
species: 765406

839338
type: SpeciesReference
stoichiometry: 1.0
species: 768286

766760
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosanoate (n-C22:0)

780658
type: Reaction
kinetic law: 780730
fast: false
name: acetyl-CoA hydrolase, mitochondrial
reactant: 780682
product: 780718
product: 780706
product: 780694
notes: SUBSYSTEM: Pyruvate Metabolism
reversible: false
reactant: 780670

780778
type: LocalParameter
value: 500.0

780766
type: LocalParameter
value: 0.0

780754
type: LocalParameter
value: 1000.0

780742
type: LocalParameter
value: 0.0

780682
type: SpeciesReference
stoichiometry: 1.0
species: 770345

780718
type: SpeciesReference
stoichiometry: 1.0
species: 770333

780706
type: SpeciesReference
stoichiometry: 1.0
species: 769851

780694
type: SpeciesReference
stoichiometry: 1.0
species: 769633

780670
type: SpeciesReference
stoichiometry: 1.0
species: 769657

765177
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Choline

786218
type: Reaction
name: ATP/ADP transport, mitochondrial
product: 786266
notes: GENE_ASSOCIATION: (NM_001151.2 or NM_001636.1 or NM_001152.1) GENE_LIST: NM_001151.2 NM_001152.1 NM_001636.1 SUBSYSTEM: Transport, Mitochondrial
product: 786254
reactant: 786230
reactant: 786242
reversible: true
fast: false
kinetic law: 786278

786266
type: SpeciesReference
stoichiometry: 1.0
species: 769681

786254
type: SpeciesReference
stoichiometry: 1.0
species: 766398

786230
type: SpeciesReference
stoichiometry: 1.0
species: 766240

786242
type: SpeciesReference
stoichiometry: 1.0
species: 769730

786326
type: LocalParameter
value: 0.0

786314
type: LocalParameter
value: 0.0

786302
type: LocalParameter
value: 1000.0

786290
type: LocalParameter
value: -1000.0

766362
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: N(omega)-(L-Arginino)succinate

847569
type: Reaction
reversible: false
reactant: 847593
product: 847630
product: 847618
product: 847605
notes: GENE_ASSOCIATION: NM_002591.2 GENE_LIST: NM_002591.2 SUBSYSTEM: Pyruvate Metabolism
reactant: 847581
fast: false
kinetic law: 847643
name: phosphoenolpyruvate carboxykinase (GTP)

847593
type: SpeciesReference
stoichiometry: 1.0
species: 768385

847630
type: SpeciesReference
stoichiometry: 1.0
species: 768776

768776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphoenolpyruvate

847618
type: SpeciesReference
stoichiometry: 1.0
species: 767597

847605
type: SpeciesReference
stoichiometry: 1.0
species: 766604

847581
type: SpeciesReference
stoichiometry: 1.0
species: 767755

847691
type: LocalParameter
value: 500.0

847679
type: LocalParameter
value: 0.0

847667
type: LocalParameter
value: 1000.0

847655
type: LocalParameter
value: 0.0

771504
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Nicotinamide adenine dinucleotide - reduced

771336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 5alpha-Cholesta-7,24-dien-3beta-ol

802612
type: Reaction
reactant: 802648
notes: GENE_ASSOCIATION: (NM_005063.4 or NM_001037582.1 or NM_024906.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
product: 802696
reversible: false
reactant: 802624
reactant: 802636
kinetic law: 802708
product: 802672
name: Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-7)
fast: false
product: 802684
reactant: 802660

802648
type: SpeciesReference
stoichiometry: 1.0
species: 768359

802696
type: SpeciesReference
stoichiometry: 1.0
species: 768323

802624
type: SpeciesReference
stoichiometry: 1.0
species: 767767

802636
type: SpeciesReference
stoichiometry: 1.0
species: 768335

802756
type: LocalParameter
value: 500.0

802744
type: LocalParameter
value: 0.0

802732
type: LocalParameter
value: 1000.0

802720
type: LocalParameter
value: 0.0

802672
type: SpeciesReference
stoichiometry: 2.0
species: 767779

802684
type: SpeciesReference
stoichiometry: 1.0
species: 767864

802660
type: SpeciesReference
stoichiometry: 1.0
species: 768825

847205
type: Reaction
kinetic law: 847266
reversible: false
reactant: 847230
product: 847254
product: 847242
fast: false
name: inorganic diphosphatase, endoplasmic reticulum
notes: GENE_ASSOCIATION: (NM_000151.1 or NM_021176.1 or NM_138387.2 or NM_001081686.1) GENE_LIST: NM_000151.1 NM_001081686.1 NM_021176.1 NM_138387.2 SUBSYSTEM: Other
reactant: 847217

847314
type: LocalParameter
value: 500.0

847302
type: LocalParameter
value: 0.0

847290
type: LocalParameter
value: 1000.0

847278
type: LocalParameter
value: 0.0

847230
type: SpeciesReference
stoichiometry: 1.0
species: 771564

771564
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Diphosphate

847254
type: SpeciesReference
stoichiometry: 2.0
species: 771552

771552
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Phosphate

847242
type: SpeciesReference
stoichiometry: 1.0
species: 771444

847217
type: SpeciesReference
stoichiometry: 1.0
species: 771456

771456
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: H2O

766156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Aminoacetone

812179
type: Reaction
product: 812265
reversible: false
product: 812277
kinetic law: 812313
reactant: 812216
product: 812301
reactant: 812203
reactant: 812228
fast: false
product: 812252
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 812191
name: fatty-acyl-CoA elongation (C22:5CoA, n3)
reactant: 812240
product: 812289

812265
type: SpeciesReference
stoichiometry: 1.0
species: 766616

812277
type: SpeciesReference
stoichiometry: 1.0
species: 767016

767016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosapentaenoyl-CoA (C22:5CoA, n-3)

812361
type: LocalParameter
value: 500.0

812349
type: LocalParameter
value: 0.0

812337
type: LocalParameter
value: 1000.0

812325
type: LocalParameter
value: 0.0

812216
type: SpeciesReference
stoichiometry: 1.0
species: 768154

812301
type: SpeciesReference
stoichiometry: 4.0
species: 768323

812203
type: SpeciesReference
stoichiometry: 5.0
species: 767767

812228
type: SpeciesReference
stoichiometry: 4.0
species: 768335

812252
type: SpeciesReference
stoichiometry: 1.0
species: 766604

812191
type: SpeciesReference
stoichiometry: 1.0
species: 767293

767293
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosapentaenoyl-CoA (C20:5CoA, n-3)

812240
type: SpeciesReference
stoichiometry: 1.0
species: 768359

812289
type: SpeciesReference
stoichiometry: 3.0
species: 767779

769149
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: tetradecanoylcarnitine (C14:0Crn)

792458
type: Reaction
reversible: true
product: 792507
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosenoyltransferase (C20:1Crn, n9), mitochondrial
product: 792495
reactant: 792483
reactant: 792470
kinetic law: 792519
fast: false

792507
type: SpeciesReference
stoichiometry: 1.0
species: 770093

792495
type: SpeciesReference
stoichiometry: 1.0
species: 769851

792483
type: SpeciesReference
stoichiometry: 1.0
species: 770069

770069
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: eicosenoyl-CoA (C20:1CoA, n-9)

792470
type: SpeciesReference
stoichiometry: 1.0
species: 769863

792567
type: LocalParameter
value: 0.0

792555
type: LocalParameter
value: 0.0

792543
type: LocalParameter
value: 1000.0

792531
type: LocalParameter
value: -1000.0

784808
type: Reaction
kinetic law: 784856
product: 784844
product: 784832
reactant: 784820
notes: GENE_ASSOCIATION: (NM_001024946.1 or NM_001024943.1 or NM_000048.3 or NM_001024944.1) GENE_LIST: NM_000048.3 NM_001024943.1 NM_001024944.1 NM_001024946.1 SUBSYSTEM: Urea Cycle
fast: false
reversible: true
name: argininosuccinate lyase

784904
type: LocalParameter
value: 0.0

784892
type: LocalParameter
value: 0.0

784880
type: LocalParameter
value: 1000.0

784868
type: LocalParameter
value: -1000.0

784844
type: SpeciesReference
stoichiometry: 1.0
species: 767537

784832
type: SpeciesReference
stoichiometry: 1.0
species: 766350

766350
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Arginine

784820
type: SpeciesReference
stoichiometry: 1.0
species: 766362

775105
type: Reaction
kinetic law: 775141
product: 775129
reactant: 775117
fast: false
reversible: true
name: L-Glutamine exchange

775189
type: LocalParameter
value: 500.0

775177
type: LocalParameter
value: 0.0

775165
type: LocalParameter
value: 1000.0

775153
type: LocalParameter
value: 0.0

775129
type: SpeciesReference
stoichiometry: 1.0
species: 772068

772068
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: gln_L_b

775117
type: SpeciesReference
stoichiometry: 1.0
species: 765357

831563
type: Reaction
kinetic law: 831599
product: 831587
reactant: 831575
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Hydroxymethylglutaryl-CoA reversible mitochondrial transport

831647
type: LocalParameter
value: 0.0

831635
type: LocalParameter
value: 0.0

831623
type: LocalParameter
value: 1000.0

831611
type: LocalParameter
value: -1000.0

831587
type: SpeciesReference
stoichiometry: 1.0
species: 770441

770441
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Hydroxymethylglutaryl-CoA

831575
type: SpeciesReference
stoichiometry: 1.0
species: 767936

767936
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Hydroxymethylglutaryl-CoA

817874
type: Reaction
reactant: 817922
product: 817983
reactant: 817934
reversible: false
product: 817946
product: 817959
product: 817995
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 817886
kinetic law: 818007
reactant: 817898
fast: false
reactant: 817910
product: 817971
name: Beta oxidation of odd chain fatty acid

817922
type: SpeciesReference
stoichiometry: 1.0
species: 770453

817983
type: SpeciesReference
stoichiometry: 1.0
species: 770634

817934
type: SpeciesReference
stoichiometry: 1.0
species: 770622

817946
type: SpeciesReference
stoichiometry: 1.0
species: 769657

817959
type: SpeciesReference
stoichiometry: 1.0
species: 770165

817995
type: SpeciesReference
stoichiometry: 1.0
species: 771058

771058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Pentanoyl-CoA (C5:0CoA)

817886
type: SpeciesReference
stoichiometry: 1.0
species: 769851

818055
type: LocalParameter
value: 500.0

818043
type: LocalParameter
value: 0.0

818031
type: LocalParameter
value: 1000.0

818019
type: LocalParameter
value: 0.0

817898
type: SpeciesReference
stoichiometry: 1.0
species: 770153

817910
type: SpeciesReference
stoichiometry: 1.0
species: 770345

817971
type: SpeciesReference
stoichiometry: 1.0
species: 770333

775683
type: Reaction
kinetic law: 775720
product: 775708
reactant: 775695
fast: false
reversible: true
name: Bicarbonate exchange

775769
type: LocalParameter
value: 500.0

775756
type: LocalParameter
value: 0.0

775744
type: LocalParameter
value: 1000.0

775732
type: LocalParameter
value: 0.0

775708
type: SpeciesReference
stoichiometry: 1.0
species: 772141

772141
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: hco3_b

775695
type: SpeciesReference
stoichiometry: 1.0
species: 765430

765430
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Bicarbonate

765780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Threonine

768654
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Orotidine 5'-phosphate

819722
type: Reaction
reactant: 819746
product: 819795
reactant: 819734
product: 819819
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
reactant: 819770
product: 819782
name: fatty acid synthase (n-C20:0)
kinetic law: 819843
reactant: 819758
product: 819807
reversible: false
fast: false
product: 819831

819746
type: SpeciesReference
stoichiometry: 1.0
species: 768154

819795
type: SpeciesReference
stoichiometry: 1.0
species: 766616

819734
type: SpeciesReference
stoichiometry: 3.0
species: 767767

819819
type: SpeciesReference
stoichiometry: 1.0
species: 767779

819770
type: SpeciesReference
stoichiometry: 1.0
species: 768397

819782
type: SpeciesReference
stoichiometry: 1.0
species: 766604

819891
type: LocalParameter
value: 500.0

819879
type: LocalParameter
value: 0.0

819867
type: LocalParameter
value: 1000.0

819855
type: LocalParameter
value: 0.0

819758
type: SpeciesReference
stoichiometry: 2.0
species: 768335

819807
type: SpeciesReference
stoichiometry: 1.0
species: 767112

819831
type: SpeciesReference
stoichiometry: 2.0
species: 768323

793671
type: Reaction
kinetic law: 793731
fast: false
product: 793719
reactant: 793695
reactant: 793683
product: 793707
reversible: true
name: eicosatrienoyl carnitine transport (C20:3Crn, n6)
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

793779
type: LocalParameter
value: 0.0

793767
type: LocalParameter
value: 0.0

793755
type: LocalParameter
value: 1000.0

793743
type: LocalParameter
value: -1000.0

793719
type: SpeciesReference
stoichiometry: 1.0
species: 770117

793695
type: SpeciesReference
stoichiometry: 1.0
species: 769863

793683
type: SpeciesReference
stoichiometry: 1.0
species: 767319

767319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatrienoyl carnitine (C20:3Crn, n-6)

793707
type: SpeciesReference
stoichiometry: 1.0
species: 766628

819903
type: Reaction
reactant: 819939
product: 819987
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
reactant: 819927
fast: false
reversible: false
kinetic law: 820023
reactant: 819951
product: 819975
name: fatty acid synthase (n-C22:0)
product: 820011
reactant: 819915
product: 819999
product: 819963

819939
type: SpeciesReference
stoichiometry: 1.0
species: 768154

819987
type: SpeciesReference
stoichiometry: 1.0
species: 766760

819927
type: SpeciesReference
stoichiometry: 3.0
species: 767767

820072
type: LocalParameter
value: 500.0

820060
type: LocalParameter
value: 0.0

820047
type: LocalParameter
value: 1000.0

820035
type: LocalParameter
value: 0.0

819951
type: SpeciesReference
stoichiometry: 2.0
species: 768335

819975
type: SpeciesReference
stoichiometry: 1.0
species: 766616

820011
type: SpeciesReference
stoichiometry: 2.0
species: 768323

819915
type: SpeciesReference
stoichiometry: 1.0
species: 767112

819999
type: SpeciesReference
stoichiometry: 1.0
species: 767779

819963
type: SpeciesReference
stoichiometry: 1.0
species: 766604

785080
type: Reaction
kinetic law: 785117
product: 785105
reactant: 785093
notes: GENE_ASSOCIATION: (NM_003486.5 or NM_012244.2 or NM_018018.2 or NM_032803.3 or NM_003045.3 or NM_001048164.1 or NM_003046.2 or NM_001008539.1 or NM_001126106.1 or NM_001126105.1 or NM_182728.1 or NM_003982.3) GENE_LIST: NM_001008539.1 NM_001048164.1 NM_001126105.1 NM_001126106.1 NM_003045.3 NM_003046.2 NM_003486.5 NM_003982.3 NM_012244.2 NM_018018.2 NM_032803.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Arginine transport, blood

785166
type: LocalParameter
value: 0.0

785154
type: LocalParameter
value: 0.0

785142
type: LocalParameter
value: 1000.0

785129
type: LocalParameter
value: -1000.0

785105
type: SpeciesReference
stoichiometry: 1.0
species: 766350

785093
type: SpeciesReference
stoichiometry: 1.0
species: 765141

765141
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Arginine

771432
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: D-Glucose

781394
type: Reaction
product: 781442
reactant: 781406
name: acetate transport in/out via proton symport
fast: false
product: 781430
reactant: 781418
kinetic law: 781454
reversible: true
notes: GENE_ASSOCIATION: (NM_013356.1 or NM_003051.3 or NM_004696.1 or NM_004731.3 or NM_001042423.1 or NM_001042422.1 or NM_004207.1 or NM_004695.2 or NM_004694.2) GENE_LIST: NM_001042422.1 NM_001042423.1 NM_003051.3 NM_004207.1 NM_004694.2 NM_004695.2 NM_004696.1 NM_004731.3 NM_013356.1 SUBSYSTEM: Transport, Extracellular

781442
type: SpeciesReference
stoichiometry: 1.0
species: 767767

781406
type: SpeciesReference
stoichiometry: 1.0
species: 765117

781430
type: SpeciesReference
stoichiometry: 1.0
species: 766168

781418
type: SpeciesReference
stoichiometry: 1.0
species: 765406

781502
type: LocalParameter
value: 0.0

781490
type: LocalParameter
value: 0.0

781478
type: LocalParameter
value: 1000.0

781466
type: LocalParameter
value: -1000.0

842273
type: Reaction
kinetic law: 842309
product: 842297
reactant: 842285
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecatrienoate (C18:3, n-3) transport

842357
type: LocalParameter
value: 0.0

842345
type: LocalParameter
value: 0.0

842333
type: LocalParameter
value: 1000.0

842321
type: LocalParameter
value: -1000.0

842297
type: SpeciesReference
stoichiometry: 1.0
species: 768446

842285
type: SpeciesReference
stoichiometry: 1.0
species: 765660

817127
type: Reaction
product: 817235
name: Beta oxidation of fatty acid
kinetic law: 817247
product: 817199
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 817151
reactant: 817139
reactant: 817163
reactant: 817175
fast: false
reactant: 817187
product: 817211
product: 817223
reversible: false

817235
type: SpeciesReference
stoichiometry: 10.0
species: 770634

817295
type: LocalParameter
value: 500.0

817283
type: LocalParameter
value: 0.0

817271
type: LocalParameter
value: 1000.0

817259
type: LocalParameter
value: 0.0

817199
type: SpeciesReference
stoichiometry: 11.0
species: 769657

817151
type: SpeciesReference
stoichiometry: 1.0
species: 769947

817139
type: SpeciesReference
stoichiometry: 10.0
species: 769851

817163
type: SpeciesReference
stoichiometry: 4.0
species: 770153

817175
type: SpeciesReference
stoichiometry: 10.0
species: 770345

817187
type: SpeciesReference
stoichiometry: 10.0
species: 770622

817211
type: SpeciesReference
stoichiometry: 4.0
species: 770165

817223
type: SpeciesReference
stoichiometry: 10.0
species: 770333

840981
type: Reaction
reactant: 840993
fast: false
reactant: 841005
notes: GENE_ASSOCIATION: NM_014595.1 GENE_LIST: NM_014595.1 SUBSYSTEM: Nucleotide Metabolism
kinetic law: 841042
reversible: false
product: 841017
name: 5'-nucleotidase (dTMP)
product: 841030

840993
type: SpeciesReference
stoichiometry: 1.0
species: 767052

767052
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dTMP

841005
type: SpeciesReference
stoichiometry: 1.0
species: 767779

841090
type: LocalParameter
value: 500.0

841078
type: LocalParameter
value: 0.0

841066
type: LocalParameter
value: 1000.0

841054
type: LocalParameter
value: 0.0

841017
type: SpeciesReference
stoichiometry: 1.0
species: 768800

841030
type: SpeciesReference
stoichiometry: 1.0
species: 769222

769222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Thymidine

793307
type: Reaction
reactant: 793319
name: eicosatetraenoyl carnitine transport (C20:4Crn, n6)
reversible: true
product: 793355
reactant: 793331
fast: false
kinetic law: 793367
product: 793343
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle

793319
type: SpeciesReference
stoichiometry: 1.0
species: 767367

793355
type: SpeciesReference
stoichiometry: 1.0
species: 770141

793331
type: SpeciesReference
stoichiometry: 1.0
species: 769863

793416
type: LocalParameter
value: 0.0

793403
type: LocalParameter
value: 0.0

793391
type: LocalParameter
value: 1000.0

793379
type: LocalParameter
value: -1000.0

793343
type: SpeciesReference
stoichiometry: 1.0
species: 766628

780163
type: Reaction
fast: false
product: 780199
kinetic law: 780223
reversible: true
reactant: 780175
product: 780211
reactant: 780187
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
name: acyl-CoA dehydrogenase, mitochondrial

780199
type: SpeciesReference
stoichiometry: 1.0
species: 769549

780271
type: LocalParameter
value: 0.0

780259
type: LocalParameter
value: 0.0

780247
type: LocalParameter
value: 1000.0

780235
type: LocalParameter
value: -1000.0

780175
type: SpeciesReference
stoichiometry: 1.0
species: 770153

780211
type: SpeciesReference
stoichiometry: 1.0
species: 770165

780187
type: SpeciesReference
stoichiometry: 1.0
species: 770513

770513
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Isovaleryl-CoA

779884
type: Reaction
notes: GENE_ASSOCIATION: NM_003051.3 GENE_LIST: NM_003051.3 SUBSYSTEM: Transport, Mitochondrial
reactant: 779909
kinetic law: 779945
product: 779921
reversible: true
fast: false
reactant: 779897
product: 779933
name: acetoacetate transport via proton symport, mitochondrial

779909
type: SpeciesReference
stoichiometry: 1.0
species: 767767

779994
type: LocalParameter
value: 0.0

779982
type: LocalParameter
value: 0.0

779969
type: LocalParameter
value: 1000.0

779957
type: LocalParameter
value: -1000.0

779921
type: SpeciesReference
stoichiometry: 1.0
species: 769645

769645
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Acetoacetate

779897
type: SpeciesReference
stoichiometry: 1.0
species: 766180

779933
type: SpeciesReference
stoichiometry: 1.0
species: 770333

836327
type: Reaction
notes: GENE_ASSOCIATION: (NM_000429.2 or (NM_005911.4 and NM_182796.1) or (NM_005911.4 and NM_013283.3)) GENE_LIST: NM_000429.2 NM_005911.4 NM_013283.3 NM_182796.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reactant: 836351
product: 836375
reactant: 836363
product: 836400
fast: false
reactant: 836339
reversible: false
name: methionine adenosyltransferase
product: 836387
kinetic law: 836412

836351
type: SpeciesReference
stoichiometry: 1.0
species: 767779

836375
type: SpeciesReference
stoichiometry: 1.0
species: 766325

836363
type: SpeciesReference
stoichiometry: 1.0
species: 768178

836400
type: SpeciesReference
stoichiometry: 1.0
species: 768885

836339
type: SpeciesReference
stoichiometry: 1.0
species: 766398

836387
type: SpeciesReference
stoichiometry: 1.0
species: 768800

836460
type: LocalParameter
value: 500.0

836448
type: LocalParameter
value: 0.0

836436
type: LocalParameter
value: 1000.0

836424
type: LocalParameter
value: 0.0

804498
type: Reaction
reactant: 804547
product: 804559
reactant: 804535
name: stearoyl-CoA desaturase (n-C22:0CoA -> C22:1CoA, n-9)
reactant: 804511
kinetic law: 804595
product: 804571
notes: SUBSYSTEM: Fatty Acid Desaturation
fast: false
product: 804583
reversible: false
reactant: 804523

804547
type: SpeciesReference
stoichiometry: 1.0
species: 768359

804559
type: SpeciesReference
stoichiometry: 1.0
species: 766968

766968
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosenoyl-CoA (C22:1CoA, n-9)

804535
type: SpeciesReference
stoichiometry: 1.0
species: 768335

804511
type: SpeciesReference
stoichiometry: 1.0
species: 766772

766772
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosanoyl-CoA (C22:0CoA)

804643
type: LocalParameter
value: 500.0

804631
type: LocalParameter
value: 0.0

804619
type: LocalParameter
value: 1000.0

804607
type: LocalParameter
value: 0.0

804571
type: SpeciesReference
stoichiometry: 2.0
species: 767779

804583
type: SpeciesReference
stoichiometry: 1.0
species: 768323

804523
type: SpeciesReference
stoichiometry: 1.0
species: 767767

768094
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ITP

768214
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: monoacylglycerol, human adipocyte

769113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Stearoylcarnitine (C18:0Crn)

842369
type: Reaction
kinetic law: 842405
product: 842393
reactant: 842381
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octadecadienoate (C18:2, n-6) transport

842454
type: LocalParameter
value: 0.0

842442
type: LocalParameter
value: 0.0

842430
type: LocalParameter
value: 1000.0

842418
type: LocalParameter
value: -1000.0

842393
type: SpeciesReference
stoichiometry: 1.0
species: 768458

842381
type: SpeciesReference
stoichiometry: 1.0
species: 765672

783089
type: Reaction
fast: false
product: 783125
name: phosphoribosylaminoimidazole carboxylase
product: 783137
kinetic law: 783149
reactant: 783113
reactant: 783101
notes: GENE_ASSOCIATION: (NM_001079524.1 or NM_006452.3 or NM_001079525.1) GENE_LIST: NM_001079524.1 NM_001079525.1 NM_006452.3 SUBSYSTEM: Nucleotide Metabolism
reversible: true

783125
type: SpeciesReference
stoichiometry: 1.0
species: 766058

766058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate

783137
type: SpeciesReference
stoichiometry: 1.0
species: 767767

783198
type: LocalParameter
value: 0.0

783186
type: LocalParameter
value: 0.0

783174
type: LocalParameter
value: 1000.0

783161
type: LocalParameter
value: -1000.0

783113
type: SpeciesReference
stoichiometry: 1.0
species: 766604

783101
type: SpeciesReference
stoichiometry: 1.0
species: 766288

766288
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-amino-1-(5-phospho-D-ribosyl)imidazole

835021
type: Reaction
reactant: 835035
product: 835072
kinetic law: 835084
product: 835060
fast: false
reversible: true
reactant: 835048
notes: GENE_ASSOCIATION: NM_003562.3 GENE_LIST: NM_003562.3 SUBSYSTEM: Transport, Mitochondrial
name: malate-alphaketoglutarate transporter

835035
type: SpeciesReference
stoichiometry: 1.0
species: 768142

835072
type: SpeciesReference
stoichiometry: 1.0
species: 770538

835133
type: LocalParameter
value: 0.0

835121
type: LocalParameter
value: 0.0

835108
type: LocalParameter
value: 1000.0

835096
type: LocalParameter
value: -1000.0

835060
type: SpeciesReference
stoichiometry: 1.0
species: 766300

835048
type: SpeciesReference
stoichiometry: 1.0
species: 769693

790889
type: Reaction
reversible: true
reactant: 790913
name: carnitine docosenoyltransferase (C22:1Crn, n9), mitochondria
kinetic law: 790949
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 790937
reactant: 790901
product: 790925
fast: false

790913
type: SpeciesReference
stoichiometry: 1.0
species: 769923

769923
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosenoyl-CoA (C22:1CoA, n-9)

790997
type: LocalParameter
value: 0.0

790985
type: LocalParameter
value: 0.0

790973
type: LocalParameter
value: 1000.0

790961
type: LocalParameter
value: -1000.0

790937
type: SpeciesReference
stoichiometry: 1.0
species: 769935

769935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosenoyl carnitine (C22:1Crn, n-9)

790901
type: SpeciesReference
stoichiometry: 1.0
species: 769863

790925
type: SpeciesReference
stoichiometry: 1.0
species: 769851

788916
type: Reaction
name: Ceramide synthase, adipocyte
fast: false
reactant: 788940
kinetic law: 788988
product: 788952
reversible: false
product: 788964
notes: GENE_ASSOCIATION: (NM_203463.1 or NM_021267.2 or NM_181746.1 or NM_024552.1 or NM_198207.1 or NM_147190.1 or NM_178842.2 or NM_022075.2) GENE_LIST: NM_021267.2 NM_022075.2 NM_024552.1 NM_147190.1 NM_178842.2 NM_181746.1 NM_198207.1 NM_203463.1 SUBSYSTEM: Sphingolipid Metabolism
reactant: 788928
product: 788976

788940
type: SpeciesReference
stoichiometry: 1.0
species: 769077

769077
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sphinganine

789036
type: LocalParameter
value: 500.0

789024
type: LocalParameter
value: 0.0

789012
type: LocalParameter
value: 1000.0

789000
type: LocalParameter
value: 0.0

788952
type: SpeciesReference
stoichiometry: 1.0
species: 766616

788964
type: SpeciesReference
stoichiometry: 0.001
species: 766736

766736
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dihydroceramide, adipoctye

788928
type: SpeciesReference
stoichiometry: 0.001
species: 767416

788976
type: SpeciesReference
stoichiometry: 1.0
species: 767767

783452
type: Reaction
fast: false
name: 2-oxoglutarate dehydrogenase, mitochondrial
product: 783512
reversible: false
reactant: 783464
reactant: 783476
product: 783500
reactant: 783488
kinetic law: 783536
notes: GENE_ASSOCIATION: ((NM_000108.3 and NM_001933.3 and NM_001003941.1) or (NM_000108.3 and NM_001933.3 and NM_002541.2)) GENE_LIST: NM_000108.3 NM_001003941.1 NM_001933.3 NM_002541.2 SUBSYSTEM: Citrate Cycle (TCA)
product: 783524

783512
type: SpeciesReference
stoichiometry: 1.0
species: 770634

783464
type: SpeciesReference
stoichiometry: 1.0
species: 769693

783476
type: SpeciesReference
stoichiometry: 1.0
species: 769851

783500
type: SpeciesReference
stoichiometry: 1.0
species: 769839

783488
type: SpeciesReference
stoichiometry: 1.0
species: 770622

783584
type: LocalParameter
value: 500.0

783572
type: LocalParameter
value: 0.0

783560
type: LocalParameter
value: 1000.0

783548
type: LocalParameter
value: 0.0

783524
type: SpeciesReference
stoichiometry: 1.0
species: 771132

771132
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Succinyl-CoA

832720
type: Reaction
kinetic law: 832780
reactant: 832732
reactant: 832744
reversible: true
product: 832756
notes: GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
name: isoleucine transaminase, mitochondrial
fast: false
product: 832768

832828
type: LocalParameter
value: 0.0

832816
type: LocalParameter
value: 0.0

832804
type: LocalParameter
value: 1000.0

832792
type: LocalParameter
value: -1000.0

832732
type: SpeciesReference
stoichiometry: 1.0
species: 769693

832744
type: SpeciesReference
stoichiometry: 1.0
species: 770501

770501
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Isoleucine

832756
type: SpeciesReference
stoichiometry: 1.0
species: 769585

832768
type: SpeciesReference
stoichiometry: 1.0
species: 770261

809392
type: Reaction
product: 809452
product: 809440
name: fatty-acid--CoA ligase (eicosanoate, C20:0)
reactant: 809428
kinetic law: 809476
reversible: true
reactant: 809404
product: 809464
reactant: 809416
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_016234.3 or NM_001009185.1 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_203380.1 or NM_015256.2) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
fast: false

809452
type: SpeciesReference
stoichiometry: 1.0
species: 767125

767125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Eicosanoyl-CoA (n-C20:0CoA)

809440
type: SpeciesReference
stoichiometry: 1.0
species: 766338

809428
type: SpeciesReference
stoichiometry: 1.0
species: 767112

809524
type: LocalParameter
value: 0.0

809512
type: LocalParameter
value: 0.0

809500
type: LocalParameter
value: 1000.0

809488
type: LocalParameter
value: -1000.0

809404
type: SpeciesReference
stoichiometry: 1.0
species: 766398

809464
type: SpeciesReference
stoichiometry: 1.0
species: 768885

809416
type: SpeciesReference
stoichiometry: 1.0
species: 766616

781976
type: Reaction
kinetic law: 782012
product: 782000
reactant: 781988
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion, blood

782060
type: LocalParameter
value: 0.0

782048
type: LocalParameter
value: 0.0

782036
type: LocalParameter
value: 1000.0

782024
type: LocalParameter
value: -1000.0

782000
type: SpeciesReference
stoichiometry: 1.0
species: 768495

781988
type: SpeciesReference
stoichiometry: 1.0
species: 765684

765684
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: ocosatetraenoate (C22:4, n-6)

791972
type: Reaction
product: 792020
kinetic law: 792032
reactant: 791996
fast: false
reversible: true
reactant: 791984
product: 792008
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1 or NM_152247.1 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine eicosenoyltransferase (C20:1Crn, n11)

792020
type: SpeciesReference
stoichiometry: 1.0
species: 767267

792080
type: LocalParameter
value: 0.0

792068
type: LocalParameter
value: 0.0

792056
type: LocalParameter
value: 1000.0

792044
type: LocalParameter
value: -1000.0

791996
type: SpeciesReference
stoichiometry: 1.0
species: 767241

791984
type: SpeciesReference
stoichiometry: 1.0
species: 766628

792008
type: SpeciesReference
stoichiometry: 1.0
species: 766616

793186
type: Reaction
reactant: 793210
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 793223
reversible: true
name: carnitine eicosatetraenoyltransferase (C20:4Crn, n6), mitochondrial
kinetic law: 793247
fast: false
product: 793235
reactant: 793198

793210
type: SpeciesReference
stoichiometry: 1.0
species: 770129

793223
type: SpeciesReference
stoichiometry: 1.0
species: 769851

793295
type: LocalParameter
value: 0.0

793283
type: LocalParameter
value: 0.0

793271
type: LocalParameter
value: 1000.0

793259
type: LocalParameter
value: -1000.0

793235
type: SpeciesReference
stoichiometry: 1.0
species: 770141

793198
type: SpeciesReference
stoichiometry: 1.0
species: 769863

829608
type: Reaction
kinetic law: 829645
product: 829632
reactant: 829620
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: H2O transport, peroxisomal

829694
type: LocalParameter
value: 0.0

829682
type: LocalParameter
value: 0.0

829670
type: LocalParameter
value: 1000.0

829658
type: LocalParameter
value: -1000.0

829632
type: SpeciesReference
stoichiometry: 1.0
species: 771732

829620
type: SpeciesReference
stoichiometry: 1.0
species: 767779

829511
type: Reaction
kinetic law: 829548
product: 829536
reactant: 829523
notes: GENE_ASSOCIATION: NM_001169.2 GENE_LIST: NM_001169.2 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: true
name: H2O transport, mitochondrial

829596
type: LocalParameter
value: 0.0

829584
type: LocalParameter
value: 0.0

829572
type: LocalParameter
value: 1000.0

829560
type: LocalParameter
value: -1000.0

829536
type: SpeciesReference
stoichiometry: 1.0
species: 770345

829523
type: SpeciesReference
stoichiometry: 1.0
species: 767779

769754
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Carbamoyl phosphate

846831
type: Reaction
kinetic law: 846892
product: 846880
reactant: 846843
fast: false
notes: GENE_ASSOCIATION: NM_021095.1 GENE_LIST: NM_021095.1 SUBSYSTEM: Transport, Extracellular
product: 846868
name: Pantothenate sodium symporter, blood
reactant: 846855
reversible: false

846940
type: LocalParameter
value: 500.0

846928
type: LocalParameter
value: 0.0

846916
type: LocalParameter
value: 1000.0

846904
type: LocalParameter
value: 0.0

846880
type: SpeciesReference
stoichiometry: 1.0
species: 768849

768849
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (R)-Pantothenate

846843
type: SpeciesReference
stoichiometry: 1.0
species: 765575

846868
type: SpeciesReference
stoichiometry: 1.0
species: 768286

846855
type: SpeciesReference
stoichiometry: 1.0
species: 765720

771708
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Glycine

832201
type: Reaction
name: 4-hydroxyphenylpyruvate dioxygenase
reversible: false
kinetic law: 832261
product: 832249
fast: false
reactant: 832225
product: 832237
notes: GENE_ASSOCIATION: NM_002150.2 GENE_LIST: NM_002150.2 SUBSYSTEM: Tyrosine metabolism
reactant: 832213

832309
type: LocalParameter
value: 500.0

832297
type: LocalParameter
value: 0.0

832285
type: LocalParameter
value: 1000.0

832273
type: LocalParameter
value: 0.0

832249
type: SpeciesReference
stoichiometry: 1.0
species: 767912

832225
type: SpeciesReference
stoichiometry: 1.0
species: 768359

832237
type: SpeciesReference
stoichiometry: 1.0
species: 766604

832213
type: SpeciesReference
stoichiometry: 1.0
species: 765950

765950
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-(4-Hydroxyphenyl)pyruvate

792580
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 792616
product: 792628
kinetic law: 792640
reactant: 792604
reactant: 792592
fast: false
name: eicosenoyl carnitine transport (C20:1Crn, n9)

792616
type: SpeciesReference
stoichiometry: 1.0
species: 766628

792628
type: SpeciesReference
stoichiometry: 1.0
species: 770093

792689
type: LocalParameter
value: 0.0

792677
type: LocalParameter
value: 0.0

792665
type: LocalParameter
value: 1000.0

792653
type: LocalParameter
value: -1000.0

792604
type: SpeciesReference
stoichiometry: 1.0
species: 769863

792592
type: SpeciesReference
stoichiometry: 1.0
species: 767280

767280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosenoyl carnitine (C20:1Crn, n9)

802360
type: Reaction
kinetic law: 802396
product: 802384
reactant: 802372
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: dodecanoate (C12:0) mammalian cell transport

802444
type: LocalParameter
value: 0.0

802432
type: LocalParameter
value: 0.0

802420
type: LocalParameter
value: 1000.0

802408
type: LocalParameter
value: -1000.0

802384
type: SpeciesReference
stoichiometry: 1.0
species: 765249

765249
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: dodecanoate (C12:0)

802372
type: SpeciesReference
stoichiometry: 1.0
species: 766833

800888
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: NM_207315.1 GENE_LIST: NM_207315.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reactant: 800912
reactant: 800900
name: cytidylate kinase (CMP), mitochondrial
kinetic law: 800948
product: 800924
product: 800936

800912
type: SpeciesReference
stoichiometry: 1.0
species: 769827

769827
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CMP

800900
type: SpeciesReference
stoichiometry: 1.0
species: 769730

800996
type: LocalParameter
value: 0.0

800984
type: LocalParameter
value: 0.0

800972
type: LocalParameter
value: 1000.0

800960
type: LocalParameter
value: -1000.0

800924
type: SpeciesReference
stoichiometry: 1.0
species: 769681

800936
type: SpeciesReference
stoichiometry: 1.0
species: 769766

771960
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ddca_b

787564
type: Reaction
product: 787612
product: 787648
name: C-4 methyl sterol oxidase NADH
notes: GENE_ASSOCIATION: (NM_006745.3 or NM_001017369.1) GENE_LIST: NM_001017369.1 NM_006745.3 SUBSYSTEM: Cholesterol Metabolism
reactant: 787576
reversible: false
reactant: 787600
fast: false
kinetic law: 787660
reactant: 787588
product: 787636
product: 787624

787612
type: SpeciesReference
stoichiometry: 1.0
species: 771360

787648
type: SpeciesReference
stoichiometry: 1.0
species: 771588

787576
type: SpeciesReference
stoichiometry: 1.0
species: 771276

787600
type: SpeciesReference
stoichiometry: 1.0
species: 771540

771540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: O2

787708
type: LocalParameter
value: 500.0

787696
type: LocalParameter
value: 0.0

787684
type: LocalParameter
value: 1000.0

787672
type: LocalParameter
value: 0.0

787588
type: SpeciesReference
stoichiometry: 1.0
species: 771492

771492
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Nicotinamide adenine dinucleotide

787636
type: SpeciesReference
stoichiometry: 1.0
species: 771504

787624
type: SpeciesReference
stoichiometry: 1.0
species: 771444

780404
type: Reaction
name: acyl-CoA dehydrogenase, mitochondrial
product: 780452
reversible: true
product: 780440
reactant: 780428
reactant: 780416
fast: false
kinetic law: 780464
notes: GENE_ASSOCIATION: NM_001609.2 GENE_LIST: NM_001609.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation

780452
type: SpeciesReference
stoichiometry: 1.0
species: 770165

780440
type: SpeciesReference
stoichiometry: 1.0
species: 769476

769476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: trans-2-Methylbut-2-enoyl-CoA

780428
type: SpeciesReference
stoichiometry: 1.0
species: 770153

780416
type: SpeciesReference
stoichiometry: 1.0
species: 769488

769488
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 2-Methylbutanoyl-CoA

780513
type: LocalParameter
value: 0.0

780501
type: LocalParameter
value: 0.0

780489
type: LocalParameter
value: 1000.0

780477
type: LocalParameter
value: -1000.0

790144
type: Reaction
kinetic law: 790180
product: 790168
reactant: 790156
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: CO2 transport out via diffusion

790228
type: LocalParameter
value: 0.0

790216
type: LocalParameter
value: 0.0

790204
type: LocalParameter
value: 1000.0

790192
type: LocalParameter
value: -1000.0

790168
type: SpeciesReference
stoichiometry: 1.0
species: 766604

790156
type: SpeciesReference
stoichiometry: 1.0
species: 765189

765189
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: CO2

765840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Valine

825389
type: Reaction
kinetic law: 825426
product: 825414
reactant: 825402
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: glycerol-3-phosphate transport, mitochondrial

825474
type: LocalParameter
value: 0.0

825462
type: LocalParameter
value: 0.0

825450
type: LocalParameter
value: 1000.0

825438
type: LocalParameter
value: -1000.0

825414
type: SpeciesReference
stoichiometry: 1.0
species: 770309

825402
type: SpeciesReference
stoichiometry: 1.0
species: 767683

777233
type: Reaction
kinetic law: 777269
product: 777257
reactant: 777245
fast: false
reversible: true
name: octadecenoate (C18:1, n-5) exchange

777318
type: LocalParameter
value: 500.0

777306
type: LocalParameter
value: 0.0

777294
type: LocalParameter
value: 1000.0

777282
type: LocalParameter
value: 0.0

777257
type: SpeciesReference
stoichiometry: 1.0
species: 772334

777245
type: SpeciesReference
stoichiometry: 1.0
species: 765623

765623
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecenoate (C18:1, n-5)

775586
type: Reaction
kinetic law: 775622
product: 775610
reactant: 775598
fast: false
reversible: true
name: H2O exchange

775671
type: LocalParameter
value: 0.0

775658
type: LocalParameter
value: 0.0

775646
type: LocalParameter
value: 1000.0

775634
type: LocalParameter
value: -1000.0

775610
type: SpeciesReference
stoichiometry: 1.0
species: 772116

775598
type: SpeciesReference
stoichiometry: 1.0
species: 765418

821472
type: Reaction
kinetic law: 821508
product: 821496
reactant: 821484
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: iron (II) transport

821557
type: LocalParameter
value: 0.0

821545
type: LocalParameter
value: 0.0

821533
type: LocalParameter
value: 1000.0

821520
type: LocalParameter
value: -1000.0

821496
type: SpeciesReference
stoichiometry: 1.0
species: 770177

821484
type: SpeciesReference
stoichiometry: 1.0
species: 767452

767452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Fe2+

780984
type: Reaction
notes: GENE_ASSOCIATION: (NM_139274.1 or NM_018677.2 or NM_023928.2) GENE_LIST: NM_018677.2 NM_023928.2 NM_139274.1 SUBSYSTEM: Pyruvate Metabolism
fast: false
product: 781044
reactant: 780996
reactant: 781008
product: 781056
name: acetyl-CoA synthetase
reactant: 781020
product: 781032
kinetic law: 781068
reversible: false

781044
type: SpeciesReference
stoichiometry: 1.0
species: 766338

780996
type: SpeciesReference
stoichiometry: 1.0
species: 766168

781008
type: SpeciesReference
stoichiometry: 1.0
species: 766398

781056
type: SpeciesReference
stoichiometry: 1.0
species: 768885

781020
type: SpeciesReference
stoichiometry: 1.0
species: 766616

781032
type: SpeciesReference
stoichiometry: 1.0
species: 766204

781117
type: LocalParameter
value: 500.0

781105
type: LocalParameter
value: 0.0

781092
type: LocalParameter
value: 1000.0

781080
type: LocalParameter
value: 0.0

855093
type: Reaction
kinetic law: 855129
product: 855117
reactant: 855105
notes: GENE_ASSOCIATION: (NM_182728.1 or NM_018593.3 or NM_012244.2 or NM_003486.5) GENE_LIST: NM_003486.5 NM_012244.2 NM_018593.3 NM_182728.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-tryptophan transport, blood

855177
type: LocalParameter
value: 0.0

855165
type: LocalParameter
value: 0.0

855153
type: LocalParameter
value: 1000.0

855141
type: LocalParameter
value: -1000.0

855117
type: SpeciesReference
stoichiometry: 1.0
species: 769270

769270
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Tryptophan

855105
type: SpeciesReference
stoichiometry: 1.0
species: 765792

765792
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Tryptophan

771576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Squalene

836860
type: Reaction
product: 836921
fast: false
notes: GENE_ASSOCIATION: NM_000431.1 GENE_LIST: NM_000431.1 SUBSYSTEM: Cholesterol Metabolism
reactant: 836884
kinetic law: 836933
product: 836909
name: mevalonate kinase (atp)
product: 836896
reversible: false
reactant: 836872

836921
type: SpeciesReference
stoichiometry: 1.0
species: 771720

836884
type: SpeciesReference
stoichiometry: 1.0
species: 771768

771768
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: (R)-Mevalonate

836981
type: LocalParameter
value: 500.0

836969
type: LocalParameter
value: 0.0

836957
type: LocalParameter
value: 1000.0

836945
type: LocalParameter
value: 0.0

836909
type: SpeciesReference
stoichiometry: 1.0
species: 771648

836896
type: SpeciesReference
stoichiometry: 1.0
species: 771636

836872
type: SpeciesReference
stoichiometry: 1.0
species: 771660

848151
type: Reaction
product: 848225
reactant: 848176
notes: GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Fatty acid activation
reactant: 848164
reactant: 848189
product: 848201
kinetic law: 848238
product: 848213
fast: false
name: propionyl-CoA synthetase, mitochondrial
reversible: true

848225
type: SpeciesReference
stoichiometry: 1.0
species: 771046

848176
type: SpeciesReference
stoichiometry: 1.0
species: 769851

848164
type: SpeciesReference
stoichiometry: 1.0
species: 769730

848189
type: SpeciesReference
stoichiometry: 1.0
species: 771021

771021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Propionate

848201
type: SpeciesReference
stoichiometry: 1.0
species: 769706

848287
type: LocalParameter
value: 0.0

848275
type: LocalParameter
value: 0.0

848263
type: LocalParameter
value: 1000.0

848250
type: LocalParameter
value: -1000.0

848213
type: SpeciesReference
stoichiometry: 1.0
species: 771034

771034
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Propanoyl-CoA (C3:0CoA)

855868
type: Reaction
product: 855904
fast: false
reversible: true
name: uridylate kinase (dUMP)
product: 855916
reactant: 855880
kinetic law: 855928
reactant: 855892
notes: GENE_ASSOCIATION: (NM_016308.1 or NM_012145.2) GENE_LIST: NM_012145.2 NM_016308.1 SUBSYSTEM: Nucleotide Metabolism

855904
type: SpeciesReference
stoichiometry: 1.0
species: 766240

855916
type: SpeciesReference
stoichiometry: 1.0
species: 767076

855880
type: SpeciesReference
stoichiometry: 1.0
species: 766398

855976
type: LocalParameter
value: 0.0

855964
type: LocalParameter
value: 0.0

855952
type: LocalParameter
value: 1000.0

855940
type: LocalParameter
value: -1000.0

855892
type: SpeciesReference
stoichiometry: 1.0
species: 767088

847994
type: Reaction
fast: false
product: 848067
reactant: 848006
reversible: false
notes: GENE_ASSOCIATION: (NM_001077447.1 or NM_024664.2) GENE_LIST: NM_001077447.1 NM_024664.2 SUBSYSTEM: CoA Biosynthesis
product: 848055
kinetic law: 848091
reactant: 848018
name: phosphopantothenate-cysteine ligase
product: 848079
reactant: 848030
product: 848042

848067
type: SpeciesReference
stoichiometry: 1.0
species: 767767

848006
type: SpeciesReference
stoichiometry: 1.0
species: 766034

766034
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-4'-Phosphopantothenate

848055
type: SpeciesReference
stoichiometry: 1.0
species: 766458

848139
type: LocalParameter
value: 500.0

848127
type: LocalParameter
value: 0.0

848115
type: LocalParameter
value: 1000.0

848103
type: LocalParameter
value: 0.0

848018
type: SpeciesReference
stoichiometry: 1.0
species: 766640

766640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CTP

848079
type: SpeciesReference
stoichiometry: 1.0
species: 768800

848030
type: SpeciesReference
stoichiometry: 1.0
species: 766652

848042
type: SpeciesReference
stoichiometry: 1.0
species: 766046

769137
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Tetradecanoyl-CoA (n-C14:0CoA)

836993
type: Reaction
kinetic law: 837029
product: 837017
reactant: 837005
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: mevalonate transport, peroxisome

837078
type: LocalParameter
value: 0.0

837066
type: LocalParameter
value: 0.0

837054
type: LocalParameter
value: 1000.0

837041
type: LocalParameter
value: -1000.0

837017
type: SpeciesReference
stoichiometry: 1.0
species: 768202

768202
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: (R)-Mevalonate

837005
type: SpeciesReference
stoichiometry: 1.0
species: 771768

830081
type: Reaction
product: 830130
notes: SUBSYSTEM: Transport, Extracellular
reversible: true
reactant: 830106
reactant: 830093
kinetic law: 830142
product: 830118
fast: false
name: bicarbonate transport (Na/HCO3 cotransport), blood

830130
type: SpeciesReference
stoichiometry: 1.0
species: 768286

830106
type: SpeciesReference
stoichiometry: 1.0
species: 765575

830093
type: SpeciesReference
stoichiometry: 1.0
species: 765430

830190
type: LocalParameter
value: 0.0

830178
type: LocalParameter
value: 0.0

830166
type: LocalParameter
value: 1000.0

830154
type: LocalParameter
value: -1000.0

830118
type: SpeciesReference
stoichiometry: 1.0
species: 767803

767803
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Bicarbonate

770780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecatrienoyl carnitine (C18:3Crn, n3)

810838
type: Reaction
name: fatty-acid--CoA ligase (docosahexaenoate, C22:6 n-3)
reversible: true
kinetic law: 810923
reactant: 810862
product: 810887
fast: false
product: 810911
product: 810899
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203380.1 or NM_015256.2 or NM_004457.3 or NM_203372.1 or NM_203379.1 or NM_016234.3 or NM_001009185.1 or NM_004458.1 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reactant: 810850
reactant: 810875

810971
type: LocalParameter
value: 0.0

810959
type: LocalParameter
value: 0.0

810947
type: LocalParameter
value: 1000.0

810935
type: LocalParameter
value: -1000.0

810862
type: SpeciesReference
stoichiometry: 1.0
species: 766616

810887
type: SpeciesReference
stoichiometry: 1.0
species: 766338

810911
type: SpeciesReference
stoichiometry: 1.0
species: 768885

810899
type: SpeciesReference
stoichiometry: 1.0
species: 766992

810850
type: SpeciesReference
stoichiometry: 1.0
species: 766398

810875
type: SpeciesReference
stoichiometry: 1.0
species: 766796

771924
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: dcsea9_b

784541
type: Reaction
product: 784601
reversible: false
reactant: 784565
reactant: 784553
name: Aldose reductase
reactant: 784577
product: 784613
fast: false
notes: SUBSYSTEM: Glycolysis/Gluconeogeneis
kinetic law: 784625
product: 784589

784601
type: SpeciesReference
stoichiometry: 1.0
species: 768335

784565
type: SpeciesReference
stoichiometry: 1.0
species: 768274

768274
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Methylglyoxal

784553
type: SpeciesReference
stoichiometry: 1.0
species: 767779

784577
type: SpeciesReference
stoichiometry: 1.0
species: 768323

784613
type: SpeciesReference
stoichiometry: 1.0
species: 768981

784674
type: LocalParameter
value: 500.0

784662
type: LocalParameter
value: 0.0

784650
type: LocalParameter
value: 1000.0

784638
type: LocalParameter
value: 0.0

784589
type: SpeciesReference
stoichiometry: 2.0
species: 767767

784686
type: Reaction
reactant: 784710
name: L-2-amino-3-oxobutanoate decarboxylation, mitochondrial
reversible: false
product: 784735
fast: false
notes: SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 784723
reactant: 784698
kinetic law: 784748

784710
type: SpeciesReference
stoichiometry: 1.0
species: 770333

784735
type: SpeciesReference
stoichiometry: 1.0
species: 769839

784723
type: SpeciesReference
stoichiometry: 1.0
species: 769621

769621
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Aminoacetone

784698
type: SpeciesReference
stoichiometry: 1.0
species: 769452

784796
type: LocalParameter
value: 500.0

784784
type: LocalParameter
value: 0.0

784772
type: LocalParameter
value: 1000.0

784760
type: LocalParameter
value: 0.0

781623
type: Reaction
kinetic law: 781671
product: 781659
reactant: 781647
reactant: 781635
notes: GENE_ASSOCIATION: (NM_013410.2 or NM_001005353.1 or NM_203464.1 or NM_013411.3 or NM_001625.2) GENE_LIST: NM_001005353.1 NM_001625.2 NM_013410.2 NM_013411.3 NM_203464.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: adenylate kinase, mitochondrial

781721
type: LocalParameter
value: 0.0

781709
type: LocalParameter
value: 0.0

781696
type: LocalParameter
value: 1000.0

781683
type: LocalParameter
value: -1000.0

781659
type: SpeciesReference
stoichiometry: 2.0
species: 769681

781647
type: SpeciesReference
stoichiometry: 1.0
species: 769730

781635
type: SpeciesReference
stoichiometry: 1.0
species: 769706

855189
type: Reaction
kinetic law: 855226
product: 855214
reactant: 855201
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Tetradecanoate (n-C14:0) transport in via uniport

855274
type: LocalParameter
value: 0.0

855262
type: LocalParameter
value: 0.0

855250
type: LocalParameter
value: 1000.0

855238
type: LocalParameter
value: -1000.0

855214
type: SpeciesReference
stoichiometry: 1.0
species: 765804

855201
type: SpeciesReference
stoichiometry: 1.0
species: 769294

766506
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3',5'-Cyclic GMP

773555
type: Reaction
kinetic law: 773591
product: 773579
reactant: 773567
fast: false
reversible: true
name: L-Aspartate exchange

773639
type: LocalParameter
value: 500.0

773627
type: LocalParameter
value: 0.0

773615
type: LocalParameter
value: 1000.0

773603
type: LocalParameter
value: 0.0

773579
type: SpeciesReference
stoichiometry: 1.0
species: 771876

771876
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: asp_L_b

773567
type: SpeciesReference
stoichiometry: 1.0
species: 765165

765165
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Aspartate

769282
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Thiosulfate

770201
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Ferrocytochrome c

854219
type: Reaction
fast: false
kinetic law: 854279
reversible: true
product: 854255
reactant: 854231
notes: GENE_ASSOCIATION: (NM_032136.3 or NM_012253.2 or NM_001064.1) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
name: transketolase
reactant: 854243
product: 854267

854328
type: LocalParameter
value: 0.0

854316
type: LocalParameter
value: 0.0

854304
type: LocalParameter
value: 1000.0

854292
type: LocalParameter
value: -1000.0

854255
type: SpeciesReference
stoichiometry: 1.0
species: 767392

854231
type: SpeciesReference
stoichiometry: 1.0
species: 767100

767100
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Erythrose 4-phosphate

854243
type: SpeciesReference
stoichiometry: 1.0
species: 769416

769416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Xylulose 5-phosphate

854267
type: SpeciesReference
stoichiometry: 1.0
species: 767561

772394
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocsttea6_b

845161
type: Reaction
reactant: 845173
reactant: 845185
fast: false
notes: GENE_ASSOCIATION: NM_012088.2 GENE_LIST: NM_012088.2 SUBSYSTEM: Pentose Phosphate Pathway
name: 6-phosphogluconolactonase
kinetic law: 845222
product: 845209
reversible: false
product: 845197

845173
type: SpeciesReference
stoichiometry: 1.0
species: 766107

845185
type: SpeciesReference
stoichiometry: 1.0
species: 767779

845271
type: LocalParameter
value: 500.0

845259
type: LocalParameter
value: 0.0

845246
type: LocalParameter
value: 1000.0

845234
type: LocalParameter
value: 0.0

845209
type: SpeciesReference
stoichiometry: 1.0
species: 767767

845197
type: SpeciesReference
stoichiometry: 1.0
species: 766095

818998
type: Reaction
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid activation
reversible: false
kinetic law: 819119
product: 819058
product: 819083
name: fatty acid synthase (C15:0), cytosol
reactant: 819034
reactant: 819022
product: 819071
reactant: 819010
reactant: 819046
product: 819095
product: 819107
fast: false

819167
type: LocalParameter
value: 500.0

819155
type: LocalParameter
value: 0.0

819143
type: LocalParameter
value: 1000.0

819131
type: LocalParameter
value: 0.0

819058
type: SpeciesReference
stoichiometry: 6.0
species: 766604

819083
type: SpeciesReference
stoichiometry: 5.0
species: 767779

819034
type: SpeciesReference
stoichiometry: 12.0
species: 768335

819022
type: SpeciesReference
stoichiometry: 6.0
species: 768154

819071
type: SpeciesReference
stoichiometry: 7.0
species: 766616

819010
type: SpeciesReference
stoichiometry: 17.0
species: 767767

819046
type: SpeciesReference
stoichiometry: 1.0
species: 768873

819095
type: SpeciesReference
stoichiometry: 12.0
species: 768323

819107
type: SpeciesReference
stoichiometry: 1.0
species: 768969

839047
type: Reaction
reactant: 839071
reactant: 839059
notes: GENE_ASSOCIATION: (NM_015440.3 or NM_005956.2) GENE_LIST: NM_005956.2 NM_015440.3
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
kinetic law: 839107
product: 839083
product: 839095
fast: false

839071
type: SpeciesReference
stoichiometry: 1.0
species: 770647

839059
type: SpeciesReference
stoichiometry: 1.0
species: 770562

839155
type: LocalParameter
value: 0.0

839143
type: LocalParameter
value: 0.0

839131
type: LocalParameter
value: 1000.0

839119
type: LocalParameter
value: -1000.0

839083
type: SpeciesReference
stoichiometry: 1.0
species: 770550

839095
type: SpeciesReference
stoichiometry: 1.0
species: 770659

774038
type: Reaction
kinetic law: 774075
product: 774063
reactant: 774050
fast: false
reversible: true
name: docosahexaenoate (C22:6, n-3) exchange

774123
type: LocalParameter
value: 500.0

774111
type: LocalParameter
value: 0.0

774099
type: LocalParameter
value: 1000.0

774087
type: LocalParameter
value: 0.0

774063
type: SpeciesReference
stoichiometry: 1.0
species: 771936

771936
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: dcshea3_b

774050
type: SpeciesReference
stoichiometry: 1.0
species: 765225

830202
type: Reaction
kinetic law: 830239
product: 830227
reactant: 830214
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecanoate (C16:0) transport

830287
type: LocalParameter
value: 0.0

830275
type: LocalParameter
value: 0.0

830263
type: LocalParameter
value: 1000.0

830251
type: LocalParameter
value: -1000.0

830227
type: SpeciesReference
stoichiometry: 1.0
species: 765442

830214
type: SpeciesReference
stoichiometry: 1.0
species: 767827

824324
type: Reaction
product: 824385
reactant: 824348
notes: GENE_ASSOCIATION: (NM_006759.3 or NM_001001521.1) GENE_LIST: NM_001001521.1 NM_006759.3 SUBSYSTEM: Glycogen Metabolism
kinetic law: 824397
reactant: 824336
fast: false
name: UTP-glucose-1-phosphate uridylyltransferase
product: 824373
reactant: 824360
reversible: true

824385
type: SpeciesReference
stoichiometry: 1.0
species: 769343

824348
type: SpeciesReference
stoichiometry: 1.0
species: 767767

824445
type: LocalParameter
value: 0.0

824433
type: LocalParameter
value: 0.0

824421
type: LocalParameter
value: 1000.0

824409
type: LocalParameter
value: -1000.0

824336
type: SpeciesReference
stoichiometry: 1.0
species: 767549

824373
type: SpeciesReference
stoichiometry: 1.0
species: 768885

824360
type: SpeciesReference
stoichiometry: 1.0
species: 769379

769379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: UTP

808381
type: Reaction
notes: GENE_ASSOCIATION: (NM_004458.1 or NM_203380.1 or NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_016234.3 or NM_203372.1 or NM_203379.1) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reversible: true
fast: false
product: 808441
kinetic law: 808465
name: fatty-acid--CoA ligase (heptadecenoate, C17:1 n-8)
product: 808429
reactant: 808393
product: 808453
reactant: 808417
reactant: 808405

808441
type: SpeciesReference
stoichiometry: 1.0
species: 767997

808513
type: LocalParameter
value: 0.0

808501
type: LocalParameter
value: 0.0

808489
type: LocalParameter
value: 1000.0

808477
type: LocalParameter
value: -1000.0

808429
type: SpeciesReference
stoichiometry: 1.0
species: 766338

808393
type: SpeciesReference
stoichiometry: 1.0
species: 766398

808453
type: SpeciesReference
stoichiometry: 1.0
species: 768885

808417
type: SpeciesReference
stoichiometry: 1.0
species: 767972

808405
type: SpeciesReference
stoichiometry: 1.0
species: 766616

818261
type: Reaction
reactant: 818273
reactant: 818322
fast: false
product: 818346
reactant: 818286
kinetic law: 818395
reactant: 818298
reactant: 818310
product: 818358
name: Beta oxidation of odd chain fatty acid
notes: GENE_ASSOCIATION: ((NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2)) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
product: 818370
reversible: false
product: 818334
product: 818383

818273
type: SpeciesReference
stoichiometry: 1.0
species: 769851

818322
type: SpeciesReference
stoichiometry: 1.0
species: 770683

818346
type: SpeciesReference
stoichiometry: 1.0
species: 770165

818286
type: SpeciesReference
stoichiometry: 1.0
species: 770153

818443
type: LocalParameter
value: 500.0

818431
type: LocalParameter
value: 0.0

818419
type: LocalParameter
value: 1000.0

818407
type: LocalParameter
value: 0.0

818298
type: SpeciesReference
stoichiometry: 1.0
species: 770345

818310
type: SpeciesReference
stoichiometry: 1.0
species: 770622

818358
type: SpeciesReference
stoichiometry: 1.0
species: 770333

818370
type: SpeciesReference
stoichiometry: 1.0
species: 770453

818334
type: SpeciesReference
stoichiometry: 1.0
species: 769657

818383
type: SpeciesReference
stoichiometry: 1.0
species: 770634

794512
type: Reaction
product: 794560
product: 794548
reactant: 794536
fast: false
kinetic law: 794572
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_152245.1 or NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 794524
reversible: true
name: carnitine hexadecenoyltransferase (C16:1Crn, n9)

794560
type: SpeciesReference
stoichiometry: 1.0
species: 767900

767900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoyl carnitine (C16:1Crn, n-9)

794548
type: SpeciesReference
stoichiometry: 1.0
species: 766616

794536
type: SpeciesReference
stoichiometry: 1.0
species: 767876

767876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: hexadecenoyl-CoA (C16:1CoA, n-9)

794620
type: LocalParameter
value: 0.0

794608
type: LocalParameter
value: 0.0

794596
type: LocalParameter
value: 1000.0

794584
type: LocalParameter
value: -1000.0

794524
type: SpeciesReference
stoichiometry: 1.0
species: 766628

768070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: myo-Inositol

817489
type: Reaction
name: Beta oxidation of odd chain fatty acid
reactant: 817525
reactant: 817549
product: 817597
product: 817585
kinetic law: 817621
reactant: 817537
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_000017.2 and (NM_000182.3 and NM_000183.1)) or (NM_000016.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000017.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2)) GENE_LIST: NM_000016.2 NM_000017.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
fast: false
reactant: 817513
reactant: 817501
reversible: false
product: 817609
product: 817561
product: 817573

817525
type: SpeciesReference
stoichiometry: 1.0
species: 770345

817549
type: SpeciesReference
stoichiometry: 1.0
species: 771058

817597
type: SpeciesReference
stoichiometry: 1.0
species: 770634

817585
type: SpeciesReference
stoichiometry: 1.0
species: 770333

817669
type: LocalParameter
value: 500.0

817657
type: LocalParameter
value: 0.0

817645
type: LocalParameter
value: 1000.0

817633
type: LocalParameter
value: 0.0

817537
type: SpeciesReference
stoichiometry: 1.0
species: 770622

817513
type: SpeciesReference
stoichiometry: 1.0
species: 770153

817501
type: SpeciesReference
stoichiometry: 1.0
species: 769851

817609
type: SpeciesReference
stoichiometry: 1.0
species: 771034

817561
type: SpeciesReference
stoichiometry: 1.0
species: 769657

817573
type: SpeciesReference
stoichiometry: 1.0
species: 770165

824457
type: Reaction
name: glyceraldehyde-3-phosphate dehydrogenase (NAD)
product: 824517
kinetic law: 824541
reversible: true
reactant: 824493
notes: GENE_ASSOCIATION: (NM_014364.3 or NM_002046.3) GENE_LIST: NM_002046.3 NM_014364.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reactant: 824481
product: 824505
product: 824529
reactant: 824469

824517
type: SpeciesReference
stoichiometry: 1.0
species: 767767

824589
type: LocalParameter
value: 0.0

824577
type: LocalParameter
value: 0.0

824565
type: LocalParameter
value: 1000.0

824553
type: LocalParameter
value: -1000.0

824493
type: SpeciesReference
stoichiometry: 1.0
species: 768800

824481
type: SpeciesReference
stoichiometry: 1.0
species: 768298

824505
type: SpeciesReference
stoichiometry: 1.0
species: 765876

824529
type: SpeciesReference
stoichiometry: 1.0
species: 768310

824469
type: SpeciesReference
stoichiometry: 1.0
species: 767561

800636
type: Reaction
product: 800672
name: L-cysteine reversible transport via sodium symport, reversible, blood
reactant: 800648
fast: false
reactant: 800660
notes: GENE_ASSOCIATION: (NM_005628.1 or NM_003038.2 or NM_018018.2 or NM_007231.1) GENE_LIST: NM_003038.2 NM_005628.1 NM_007231.1 NM_018018.2 SUBSYSTEM: Transport, Extracellular
kinetic law: 800696
product: 800684
reversible: true

800672
type: SpeciesReference
stoichiometry: 1.0
species: 766652

800648
type: SpeciesReference
stoichiometry: 1.0
species: 765201

800660
type: SpeciesReference
stoichiometry: 1.0
species: 765575

800747
type: LocalParameter
value: 0.0

800734
type: LocalParameter
value: 0.0

800721
type: LocalParameter
value: 1000.0

800708
type: LocalParameter
value: -1000.0

800684
type: SpeciesReference
stoichiometry: 1.0
species: 768286

771984
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ecsea11_b

799607
type: Reaction
reactant: 799631
product: 799655
reactant: 799643
name: citrate synthase
notes: GENE_ASSOCIATION: (NM_198324.1 or NM_004077.2) GENE_LIST: NM_004077.2 NM_198324.1 SUBSYSTEM: Citrate Cycle (TCA)
product: 799680
kinetic law: 799692
fast: false
reactant: 799619
product: 799667
reversible: false

799631
type: SpeciesReference
stoichiometry: 1.0
species: 770345

799655
type: SpeciesReference
stoichiometry: 1.0
species: 769790

799643
type: SpeciesReference
stoichiometry: 1.0
species: 770719

799680
type: SpeciesReference
stoichiometry: 1.0
species: 770333

799742
type: LocalParameter
value: 500.0

799729
type: LocalParameter
value: 0.0

799717
type: LocalParameter
value: 1000.0

799704
type: LocalParameter
value: 0.0

799619
type: SpeciesReference
stoichiometry: 1.0
species: 769657

799667
type: SpeciesReference
stoichiometry: 1.0
species: 769851

838034
type: Reaction
kinetic law: 838070
product: 838058
reactant: 838046
notes: GENE_ASSOCIATION: NM_000255.1 GENE_LIST: NM_000255.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: methylmalonyl-CoA mutase

838118
type: LocalParameter
value: 0.0

838106
type: LocalParameter
value: 0.0

838094
type: LocalParameter
value: 1000.0

838082
type: LocalParameter
value: -1000.0

838058
type: SpeciesReference
stoichiometry: 1.0
species: 771132

838046
type: SpeciesReference
stoichiometry: 1.0
species: 770598

770598
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (R)-Methylmalonyl-CoA

795608
type: Reaction
product: 795644
notes: GENE_ASSOCIATION: (NM_152359.1 or NM_004377.2 or NM_001031847.1 or NM_152247.1 or NM_152245.1 or NM_152246.1 or NM_001876.2) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
reactant: 795620
kinetic law: 795668
fast: false
name: carnitine octadecenoyltransferase (C18:1Crn, n9)
reversible: true
reactant: 795632
product: 795656

795644
type: SpeciesReference
stoichiometry: 1.0
species: 766616

795620
type: SpeciesReference
stoichiometry: 1.0
species: 766628

795717
type: LocalParameter
value: 0.0

795705
type: LocalParameter
value: 0.0

795693
type: LocalParameter
value: 1000.0

795681
type: LocalParameter
value: -1000.0

795632
type: SpeciesReference
stoichiometry: 1.0
species: 768581

795656
type: SpeciesReference
stoichiometry: 1.0
species: 768618

807368
type: Reaction
reactant: 807405
reactant: 807393
product: 807441
notes: GENE_ASSOCIATION: (NM_022977.1 or NM_004457.3 or NM_001995.2 or NM_203379.1 or NM_015256.2 or NM_203372.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1 or NM_004458.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
name: fatty-acid--CoA ligase (tetradecanoate)
reactant: 807381
product: 807417
kinetic law: 807453
reversible: true
fast: false
product: 807429

807405
type: SpeciesReference
stoichiometry: 1.0
species: 769294

807393
type: SpeciesReference
stoichiometry: 1.0
species: 766616

807441
type: SpeciesReference
stoichiometry: 1.0
species: 769137

807381
type: SpeciesReference
stoichiometry: 1.0
species: 766398

807417
type: SpeciesReference
stoichiometry: 1.0
species: 766338

807503
type: LocalParameter
value: 0.0

807491
type: LocalParameter
value: 0.0

807478
type: LocalParameter
value: 1000.0

807465
type: LocalParameter
value: -1000.0

807429
type: SpeciesReference
stoichiometry: 1.0
species: 768885

768190
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5,10-Methenyltetrahydrofolate

777715
type: Reaction
kinetic law: 777751
product: 777739
reactant: 777727
fast: false
reversible: true
name: ocosatetraenoate (C22:4, n-6) exchange

777799
type: LocalParameter
value: 500.0

777787
type: LocalParameter
value: 0.0

777775
type: LocalParameter
value: 1000.0

777763
type: LocalParameter
value: 0.0

777739
type: SpeciesReference
stoichiometry: 1.0
species: 772394

777727
type: SpeciesReference
stoichiometry: 1.0
species: 765684

811600
type: Reaction
product: 811708
product: 811696
reactant: 811624
product: 811684
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 811612
kinetic law: 811732
product: 811720
reactant: 811648
product: 811672
fast: false
name: fatty-acyl-CoA elongation (n-C20:3CoA, n6)
reactant: 811636
reversible: false
reactant: 811660

811708
type: SpeciesReference
stoichiometry: 3.0
species: 767779

811696
type: SpeciesReference
stoichiometry: 1.0
species: 767306

767306
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatrienoyl-CoA (C20:3CoA, n-6)

811624
type: SpeciesReference
stoichiometry: 1.0
species: 768154

811684
type: SpeciesReference
stoichiometry: 1.0
species: 766616

811612
type: SpeciesReference
stoichiometry: 5.0
species: 767767

811781
type: LocalParameter
value: 500.0

811768
type: LocalParameter
value: 0.0

811756
type: LocalParameter
value: 1000.0

811744
type: LocalParameter
value: 0.0

811720
type: SpeciesReference
stoichiometry: 4.0
species: 768323

811648
type: SpeciesReference
stoichiometry: 1.0
species: 768359

811672
type: SpeciesReference
stoichiometry: 1.0
species: 766604

811636
type: SpeciesReference
stoichiometry: 4.0
species: 768335

811660
type: SpeciesReference
stoichiometry: 1.0
species: 768532

802768
type: Reaction
kinetic law: 802864
product: 802852
reactant: 802816
reactant: 802804
product: 802828
notes: SUBSYSTEM: Fatty Acid Desaturation
reactant: 802780
fast: false
reactant: 802792
product: 802840
name: Palmitoyl-CoA desaturase (n-C16:0CoA -> C16:1CoA, n-9)
reversible: false

802912
type: LocalParameter
value: 500.0

802900
type: LocalParameter
value: 0.0

802888
type: LocalParameter
value: 1000.0

802876
type: LocalParameter
value: 0.0

802852
type: SpeciesReference
stoichiometry: 1.0
species: 768323

802816
type: SpeciesReference
stoichiometry: 1.0
species: 768825

802804
type: SpeciesReference
stoichiometry: 1.0
species: 768359

802828
type: SpeciesReference
stoichiometry: 2.0
species: 767779

802780
type: SpeciesReference
stoichiometry: 1.0
species: 767767

802792
type: SpeciesReference
stoichiometry: 1.0
species: 768335

802840
type: SpeciesReference
stoichiometry: 1.0
species: 767876

806810
type: Reaction
kinetic law: 806846
product: 806834
reactant: 806822
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatrienoate (C20:3, n-6) transport

806898
type: LocalParameter
value: 0.0

806885
type: LocalParameter
value: 0.0

806872
type: LocalParameter
value: 1000.0

806859
type: LocalParameter
value: -1000.0

806834
type: SpeciesReference
stoichiometry: 1.0
species: 767189

806822
type: SpeciesReference
stoichiometry: 1.0
species: 765297

848944
type: Reaction
name: Na+/Proline-L symporter, blood
product: 848980
reactant: 848968
product: 848992
fast: false
notes: GENE_ASSOCIATION: (NM_030674.2 or NM_018976.3 or NM_001077484.1) GENE_LIST: NM_001077484.1 NM_018976.3 NM_030674.2 SUBSYSTEM: Transport, Extracellular
reversible: true
kinetic law: 849004
reactant: 848956

848980
type: SpeciesReference
stoichiometry: 1.0
species: 768286

848968
type: SpeciesReference
stoichiometry: 1.0
species: 765732

848992
type: SpeciesReference
stoichiometry: 1.0
species: 768921

849053
type: LocalParameter
value: 0.0

849041
type: LocalParameter
value: 0.0

849028
type: LocalParameter
value: 1000.0

849016
type: LocalParameter
value: -1000.0

848956
type: SpeciesReference
stoichiometry: 1.0
species: 765575

804026
type: Reaction
fast: false
reactant: 804038
product: 804086
reactant: 804050
product: 804110
reactant: 804074
kinetic law: 804122
reversible: false
reactant: 804062
name: stearoyl-CoA desaturase (n-C20:0CoA -> C20:1CoA, n-9)
notes: SUBSYSTEM: Fatty Acid Synthesis
product: 804098

804038
type: SpeciesReference
stoichiometry: 1.0
species: 767125

804086
type: SpeciesReference
stoichiometry: 1.0
species: 767254

804050
type: SpeciesReference
stoichiometry: 1.0
species: 767767

804110
type: SpeciesReference
stoichiometry: 1.0
species: 768323

804074
type: SpeciesReference
stoichiometry: 1.0
species: 768359

804171
type: LocalParameter
value: 500.0

804158
type: LocalParameter
value: 0.0

804146
type: LocalParameter
value: 1000.0

804134
type: LocalParameter
value: 0.0

804062
type: SpeciesReference
stoichiometry: 1.0
species: 768335

804098
type: SpeciesReference
stoichiometry: 2.0
species: 767779

765539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Leucine

773941
type: Reaction
kinetic law: 773978
product: 773966
reactant: 773954
fast: false
reversible: true
name: docosenoate (C22:1, n-9) exchange

774026
type: LocalParameter
value: 500.0

774014
type: LocalParameter
value: 0.0

774002
type: LocalParameter
value: 1000.0

773990
type: LocalParameter
value: 0.0

773966
type: SpeciesReference
stoichiometry: 1.0
species: 771924

773954
type: SpeciesReference
stoichiometry: 1.0
species: 765213

765213
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: docosenoate (C22:1, n-9)

777426
type: Reaction
kinetic law: 777462
product: 777450
reactant: 777438
fast: false
reversible: true
name: octadecenoate (C18:1, n-9) exchange

777510
type: LocalParameter
value: 500.0

777498
type: LocalParameter
value: 0.0

777486
type: LocalParameter
value: 1000.0

777474
type: LocalParameter
value: 0.0

777450
type: SpeciesReference
stoichiometry: 1.0
species: 772358

772358
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ocdcea9_b

777438
type: SpeciesReference
stoichiometry: 1.0
species: 765648

765648
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: octadecenoate (C18:1, n-9)

837937
type: Reaction
kinetic law: 837974
product: 837962
reactant: 837950
notes: GENE_ASSOCIATION: NM_032601.2 GENE_LIST: NM_032601.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
fast: false
reversible: true
name: methylmalonyl-CoA epimerase, mitochondrial

838022
type: LocalParameter
value: 0.0

838010
type: LocalParameter
value: 0.0

837998
type: LocalParameter
value: 1000.0

837986
type: LocalParameter
value: -1000.0

837962
type: SpeciesReference
stoichiometry: 1.0
species: 770598

837950
type: SpeciesReference
stoichiometry: 1.0
species: 770610

770610
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-Methylmalonyl-CoA

790769
type: Reaction
product: 790805
product: 790817
notes: GENE_ASSOCIATION: (NM_152247.1 or NM_152245.1 or NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine docosenoyltransferase (C22:1Crn, n9)
reversible: true
reactant: 790781
fast: false
kinetic law: 790829
reactant: 790793

790805
type: SpeciesReference
stoichiometry: 1.0
species: 766616

790817
type: SpeciesReference
stoichiometry: 1.0
species: 766980

766980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: docosenoyl carnitine (C22:1Crn, n-9)

790781
type: SpeciesReference
stoichiometry: 1.0
species: 766628

790877
type: LocalParameter
value: 0.0

790865
type: LocalParameter
value: 0.0

790853
type: LocalParameter
value: 1000.0

790841
type: LocalParameter
value: -1000.0

790793
type: SpeciesReference
stoichiometry: 1.0
species: 766968

854097
type: Reaction
fast: false
reversible: true
product: 854134
notes: GENE_ASSOCIATION: (NM_032136.3 or NM_001064.1 or NM_012253.2) GENE_LIST: NM_001064.1 NM_012253.2 NM_032136.3 SUBSYSTEM: Pentose Phosphate Pathway
kinetic law: 854159
reactant: 854109
name: transketolase
product: 854146
reactant: 854122

854134
type: SpeciesReference
stoichiometry: 1.0
species: 767561

854207
type: LocalParameter
value: 0.0

854195
type: LocalParameter
value: 0.0

854183
type: LocalParameter
value: 1000.0

854171
type: LocalParameter
value: -1000.0

854109
type: SpeciesReference
stoichiometry: 1.0
species: 768993

854146
type: SpeciesReference
stoichiometry: 1.0
species: 769017

769017
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sedoheptulose 7-phosphate

854122
type: SpeciesReference
stoichiometry: 1.0
species: 769416

766410
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Butyrate

835266
type: Reaction
kinetic law: 835326
name: malate transport, mitochondrial
reactant: 835278
notes: GENE_ASSOCIATION: NM_012140.3 GENE_LIST: NM_012140.3 SUBSYSTEM: Transport, Mitochondrial
reversible: true
reactant: 835290
fast: false
product: 835302
product: 835314

835374
type: LocalParameter
value: 0.0

835362
type: LocalParameter
value: 0.0

835350
type: LocalParameter
value: 1000.0

835338
type: LocalParameter
value: -1000.0

835278
type: SpeciesReference
stoichiometry: 1.0
species: 768142

835290
type: SpeciesReference
stoichiometry: 1.0
species: 770985

835302
type: SpeciesReference
stoichiometry: 1.0
species: 768800

835314
type: SpeciesReference
stoichiometry: 1.0
species: 770538

821230
type: Reaction
product: 821266
reversible: false
fast: false
name: Fructose-2,6-bisphosphate 2-phosphatase
kinetic law: 821291
product: 821278
reactant: 821242
notes: GENE_ASSOCIATION: (NM_004566.2 or NM_006212.2 or NM_003837.2 or NM_000507.2 or NM_004567.2 or NM_001018053.1 or NM_002625.1) GENE_LIST: NM_000507.2 NM_001018053.1 NM_002625.1 NM_003837.2 NM_004566.2 NM_004567.2 NM_006212.2 SUBSYSTEM: Fructose and Mannose Metabolism
reactant: 821254

821266
type: SpeciesReference
stoichiometry: 1.0
species: 767392

821339
type: LocalParameter
value: 500.0

821327
type: LocalParameter
value: 0.0

821315
type: LocalParameter
value: 1000.0

821303
type: LocalParameter
value: 0.0

821278
type: SpeciesReference
stoichiometry: 1.0
species: 768800

821242
type: SpeciesReference
stoichiometry: 1.0
species: 767380

821254
type: SpeciesReference
stoichiometry: 1.0
species: 767779

801261
type: Reaction
product: 801309
fast: false
product: 801297
reactant: 801273
product: 801321
notes: GENE_ASSOCIATION: (NM_006133.1 or NM_139179.1) GENE_LIST: NM_006133.1 NM_139179.1 SUBSYSTEM: Triglycerol Degradation
name: diacylglycerol hydrolase, human adipocyte
kinetic law: 801333
reversible: false
reactant: 801285

801309
type: SpeciesReference
stoichiometry: 1.0
species: 767767

801297
type: SpeciesReference
stoichiometry: 0.001
species: 767404

801273
type: SpeciesReference
stoichiometry: 0.001
species: 765864

801321
type: SpeciesReference
stoichiometry: 0.001
species: 768214

801381
type: LocalParameter
value: 500.0

801369
type: LocalParameter
value: 0.0

801357
type: LocalParameter
value: 1000.0

801345
type: LocalParameter
value: 0.0

801285
type: SpeciesReference
stoichiometry: 1.0
species: 767779

766482
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: CDPdiacylglycerol, human adipocyte

828883
type: Reaction
notes: GENE_ASSOCIATION: (NM_000161.2 or NM_001024024.1) GENE_LIST: NM_000161.2 NM_001024024.1 SUBSYSTEM: Tetrahydrobiopterin
reactant: 828895
reversible: false
reactant: 828907
product: 828943
name: GTP cyclohydrolase I
kinetic law: 828955
product: 828931
fast: false
product: 828919

828895
type: SpeciesReference
stoichiometry: 1.0
species: 767755

828907
type: SpeciesReference
stoichiometry: 1.0
species: 767779

828943
type: SpeciesReference
stoichiometry: 1.0
species: 767767

829003
type: LocalParameter
value: 500.0

828991
type: LocalParameter
value: 0.0

828979
type: LocalParameter
value: 1000.0

828967
type: LocalParameter
value: 0.0

828931
type: SpeciesReference
stoichiometry: 1.0
species: 767488

828919
type: SpeciesReference
stoichiometry: 1.0
species: 766264

766264
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 2-Amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate

823555
type: Reaction
product: 823627
product: 823615
notes: GENE_ASSOCIATION: (NM_002860.3 or NM_001017423.1) GENE_LIST: NM_001017423.1 NM_002860.3 SUBSYSTEM: Arginine and Proline Metabolism
fast: false
reactant: 823591
reactant: 823567
kinetic law: 823639
product: 823603
reactant: 823579
reversible: false
name: glutamate-5-semialdehyde dehydrogenase, mitochondrial

823627
type: SpeciesReference
stoichiometry: 1.0
species: 770985

823615
type: SpeciesReference
stoichiometry: 1.0
species: 770647

823591
type: SpeciesReference
stoichiometry: 1.0
species: 770659

823567
type: SpeciesReference
stoichiometry: 1.0
species: 770273

823687
type: LocalParameter
value: 500.0

823675
type: LocalParameter
value: 0.0

823663
type: LocalParameter
value: 1000.0

823651
type: LocalParameter
value: 0.0

823603
type: SpeciesReference
stoichiometry: 1.0
species: 770285

770285
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Glutamate 5-semialdehyde

823579
type: SpeciesReference
stoichiometry: 1.0
species: 770333

771192
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 5,6,7,8-Tetrahydrofolate

794995
type: Reaction
reversible: true
product: 795043
product: 795031
reactant: 795019
kinetic law: 795055
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine octadecenoyltransferase (C18:1Crn, n5), mitochondrial
reactant: 795007

795043
type: SpeciesReference
stoichiometry: 1.0
species: 770829

770829
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl carnitine (C18:1Crn, n5)

795031
type: SpeciesReference
stoichiometry: 1.0
species: 769851

795019
type: SpeciesReference
stoichiometry: 1.0
species: 770792

795103
type: LocalParameter
value: 0.0

795091
type: LocalParameter
value: 0.0

795079
type: LocalParameter
value: 1000.0

795067
type: LocalParameter
value: -1000.0

795007
type: SpeciesReference
stoichiometry: 1.0
species: 769863

803868
type: Reaction
reactant: 803880
kinetic law: 803966
fast: false
product: 803941
product: 803953
name: stearoyl-CoA desaturase (n-C20:0CoA -> C20:1CoA, n-11)
reactant: 803893
notes: GENE_ASSOCIATION: (NM_005063.4 or NM_024906.1 or NM_001037582.1) GENE_LIST: NM_001037582.1 NM_005063.4 NM_024906.1 SUBSYSTEM: Fatty Acid Desaturation
reactant: 803917
reactant: 803905
reversible: false
product: 803929

803880
type: SpeciesReference
stoichiometry: 1.0
species: 767125

804014
type: LocalParameter
value: 500.0

804002
type: LocalParameter
value: 0.0

803990
type: LocalParameter
value: 1000.0

803978
type: LocalParameter
value: 0.0

803941
type: SpeciesReference
stoichiometry: 2.0
species: 767779

803953
type: SpeciesReference
stoichiometry: 1.0
species: 768323

803893
type: SpeciesReference
stoichiometry: 1.0
species: 767767

803917
type: SpeciesReference
stoichiometry: 1.0
species: 768359

803905
type: SpeciesReference
stoichiometry: 1.0
species: 768335

803929
type: SpeciesReference
stoichiometry: 1.0
species: 767241

813442
type: Reaction
reactant: 813503
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001608.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000016.2 and NM_001919.2 and (NM_000182.3 and NM_000183.1))... GENE_LIST: ... NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 813528
reactant: 813491
reversible: false
product: 813540
kinetic law: 813564
reactant: 813454
reactant: 813466
product: 813552
fast: false
product: 813515
name: Beta oxidation of fatty acid
reactant: 813479

813503
type: SpeciesReference
stoichiometry: 1.0
species: 771168

813528
type: SpeciesReference
stoichiometry: 5.0
species: 770165

813491
type: SpeciesReference
stoichiometry: 6.0
species: 770622

813540
type: SpeciesReference
stoichiometry: 6.0
species: 770333

813613
type: LocalParameter
value: 500.0

813601
type: LocalParameter
value: 0.0

813589
type: LocalParameter
value: 1000.0

813576
type: LocalParameter
value: 0.0

813454
type: SpeciesReference
stoichiometry: 6.0
species: 769851

813466
type: SpeciesReference
stoichiometry: 5.0
species: 770153

813552
type: SpeciesReference
stoichiometry: 6.0
species: 770634

813515
type: SpeciesReference
stoichiometry: 7.0
species: 769657

813479
type: SpeciesReference
stoichiometry: 6.0
species: 770345

812374
type: Reaction
kinetic law: 812410
product: 812398
reactant: 812386
notes: SUBSYSTEM: Glycine and Serine Metabolism
fast: false
reversible: true
name: formaldehyde transport, peroxisomal

812459
type: LocalParameter
value: 0.0

812446
type: LocalParameter
value: 0.0

812434
type: LocalParameter
value: 1000.0

812422
type: LocalParameter
value: -1000.0

812398
type: SpeciesReference
stoichiometry: 1.0
species: 771696

771696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Formaldehyde

812386
type: SpeciesReference
stoichiometry: 1.0
species: 767428

767645
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Glutamate 5-semialdehyde

767512
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

833916
type: Reaction
product: 833976
reversible: true
reactant: 833940
product: 833952
notes: GENE_ASSOCIATION: ((NM_002300.3 and NM_005566.1) or NM_005566.1 or NM_144972.3 or NM_033195.1 or NM_002300.3 or NM_002301.2 or NM_017448.1 or NM_018314.2) GENE_LIST: NM_002300.3 NM_002301.2 NM_005566.1 NM_017448.1 NM_018314.2 NM_033195.1 NM_144972.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 833964
reactant: 833928
name: L-lactate dehydrogenase
fast: false
kinetic law: 833988

833976
type: SpeciesReference
stoichiometry: 1.0
species: 768981

833940
type: SpeciesReference
stoichiometry: 1.0
species: 768298

833952
type: SpeciesReference
stoichiometry: 1.0
species: 767767

833964
type: SpeciesReference
stoichiometry: 1.0
species: 768310

833928
type: SpeciesReference
stoichiometry: 1.0
species: 768106

768106
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Lactate

834036
type: LocalParameter
value: 0.0

834024
type: LocalParameter
value: 0.0

834012
type: LocalParameter
value: 1000.0

834000
type: LocalParameter
value: -1000.0

772286
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: na1_b

772128
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: h_b

822080
type: Reaction
kinetic law: 822116
product: 822104
reactant: 822092
notes: SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: Farnesyl diphosphate transport

822164
type: LocalParameter
value: 0.0

822152
type: LocalParameter
value: 0.0

822140
type: LocalParameter
value: 1000.0

822128
type: LocalParameter
value: -1000.0

822104
type: SpeciesReference
stoichiometry: 1.0
species: 771408

771408
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Farnesyl diphosphate

822092
type: SpeciesReference
stoichiometry: 1.0
species: 767524

767524
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Farnesyl diphosphate

792701
type: Reaction
notes: GENE_ASSOCIATION: (NM_152246.1 or NM_001876.2 or NM_152359.1 or NM_004377.2 or NM_001031847.1 or NM_152247.1 or NM_152245.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 792751
reactant: 792713
reversible: true
product: 792738
reactant: 792725
kinetic law: 792763
name: carnitine eicosadienoyltransferase (C20:2Crn, n6)
fast: false

792751
type: SpeciesReference
stoichiometry: 1.0
species: 767228

792713
type: SpeciesReference
stoichiometry: 1.0
species: 766628

792738
type: SpeciesReference
stoichiometry: 1.0
species: 766616

792725
type: SpeciesReference
stoichiometry: 1.0
species: 767215

792812
type: LocalParameter
value: 0.0

792799
type: LocalParameter
value: 0.0

792787
type: LocalParameter
value: 1000.0

792775
type: LocalParameter
value: -1000.0

806617
type: Reaction
kinetic law: 806653
product: 806641
reactant: 806629
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: eicosenoate (C20:1, n-9) transport

806701
type: LocalParameter
value: 0.0

806689
type: LocalParameter
value: 0.0

806677
type: LocalParameter
value: 1000.0

806665
type: LocalParameter
value: -1000.0

806641
type: SpeciesReference
stoichiometry: 1.0
species: 765285

765285
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: eicosenoate (C20:1, n-9)

806629
type: SpeciesReference
stoichiometry: 1.0
species: 767177

792945
type: Reaction
product: 792993
kinetic law: 793006
reactant: 792957
reversible: true
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 792981
reactant: 792969
name: eicosadienoyl carnitine transport (C20:2Crn, n6)
fast: false

792993
type: SpeciesReference
stoichiometry: 1.0
species: 770044

793054
type: LocalParameter
value: 0.0

793042
type: LocalParameter
value: 0.0

793030
type: LocalParameter
value: 1000.0

793018
type: LocalParameter
value: -1000.0

792957
type: SpeciesReference
stoichiometry: 1.0
species: 767228

792981
type: SpeciesReference
stoichiometry: 1.0
species: 766628

792969
type: SpeciesReference
stoichiometry: 1.0
species: 769863

782290
type: Reaction
product: 782362
reactant: 782326
reversible: false
product: 782374
name: adenylosuccinate synthetase
kinetic law: 782386
notes: GENE_ASSOCIATION: (NM_152328.3 or NM_199165.1 or NM_001126.2) GENE_LIST: NM_001126.2 NM_152328.3 NM_199165.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 782314
fast: false
reactant: 782302
product: 782338
product: 782350

782362
type: SpeciesReference
stoichiometry: 2.0
species: 767767

782326
type: SpeciesReference
stoichiometry: 1.0
species: 768058

782374
type: SpeciesReference
stoichiometry: 1.0
species: 768800

782436
type: LocalParameter
value: 500.0

782424
type: LocalParameter
value: 0.0

782412
type: LocalParameter
value: 1000.0

782399
type: LocalParameter
value: 0.0

782314
type: SpeciesReference
stoichiometry: 1.0
species: 767755

782302
type: SpeciesReference
stoichiometry: 1.0
species: 766386

782338
type: SpeciesReference
stoichiometry: 1.0
species: 766712

782350
type: SpeciesReference
stoichiometry: 1.0
species: 767597

796215
type: Reaction
reactant: 796239
notes: GENE_ASSOCIATION: (NM_001039355.1 or NM_000387.3) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 796275
reversible: true
reactant: 796227
product: 796263
product: 796251
fast: false
name: octadecadienoyl carnitine transferase (C18:2Crn, n6)

796239
type: SpeciesReference
stoichiometry: 1.0
species: 769863

796324
type: LocalParameter
value: 0.0

796312
type: LocalParameter
value: 0.0

796300
type: LocalParameter
value: 1000.0

796287
type: LocalParameter
value: -1000.0

796227
type: SpeciesReference
stoichiometry: 1.0
species: 768482

768482
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecadienoyl carnitine (C18:2Crn, n-6)

796263
type: SpeciesReference
stoichiometry: 1.0
species: 770756

796251
type: SpeciesReference
stoichiometry: 1.0
species: 766628

779449
type: Reaction
kinetic law: 779485
product: 779473
reactant: 779461
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: Aminoacetone transport (mitochondrial)

779533
type: LocalParameter
value: 500.0

779521
type: LocalParameter
value: 0.0

779509
type: LocalParameter
value: 1000.0

779497
type: LocalParameter
value: 0.0

779473
type: SpeciesReference
stoichiometry: 1.0
species: 766156

779461
type: SpeciesReference
stoichiometry: 1.0
species: 769621

783596
type: Reaction
reactant: 783608
fast: false
product: 783645
product: 783633
reversible: true
notes: GENE_ASSOCIATION: (NM_005309.1 or NM_133443.1) GENE_LIST: NM_005309.1 NM_133443.1 SUBSYSTEM: Alanine and Aspartate Metabolism
kinetic law: 783657
reactant: 783620
name: L-alanine transaminase

783608
type: SpeciesReference
stoichiometry: 1.0
species: 766300

783645
type: SpeciesReference
stoichiometry: 1.0
species: 768981

783633
type: SpeciesReference
stoichiometry: 1.0
species: 767633

783705
type: LocalParameter
value: 0.0

783693
type: LocalParameter
value: 0.0

783681
type: LocalParameter
value: 1000.0

783669
type: LocalParameter
value: -1000.0

783620
type: SpeciesReference
stoichiometry: 1.0
species: 766313

766313
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Alanine

839822
type: Reaction
notes: GENE_ASSOCIATION: NM_005009.2 GENE_LIST: NM_005009.2 SUBSYSTEM: Nucleotide Metabolism
product: 839870
reactant: 839846
reversible: true
fast: false
reactant: 839834
kinetic law: 839882
name: nucleoside-diphosphate kinase (ATP:GDP)
product: 839858

839870
type: SpeciesReference
stoichiometry: 1.0
species: 770321

839846
type: SpeciesReference
stoichiometry: 1.0
species: 770237

839834
type: SpeciesReference
stoichiometry: 1.0
species: 769730

839930
type: LocalParameter
value: 0.0

839918
type: LocalParameter
value: 0.0

839906
type: LocalParameter
value: 1000.0

839894
type: LocalParameter
value: -1000.0

839858
type: SpeciesReference
stoichiometry: 1.0
species: 769681

801781
type: Reaction
fast: false
reactant: 801793
reactant: 801805
kinetic law: 801877
product: 801865
reversible: false
reactant: 801817
product: 801853
notes: GENE_ASSOCIATION: (NM_003676.2 or NM_144780.1 or NM_206918.1) GENE_LIST: NM_003676.2 NM_144780.1 NM_206918.1 SUBSYSTEM: Phospholipid Metabolism
product: 801841
reactant: 801829
name: Dihydroceramide desaturase, adipocyte

801793
type: SpeciesReference
stoichiometry: 0.001
species: 766736

801805
type: SpeciesReference
stoichiometry: 1.0
species: 767767

801927
type: LocalParameter
value: 500.0

801914
type: LocalParameter
value: 0.0

801902
type: LocalParameter
value: 1000.0

801889
type: LocalParameter
value: 0.0

801865
type: SpeciesReference
stoichiometry: 1.0
species: 768323

801817
type: SpeciesReference
stoichiometry: 1.0
species: 768335

801853
type: SpeciesReference
stoichiometry: 2.0
species: 767779

801841
type: SpeciesReference
stoichiometry: 0.001
species: 766494

766494
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: ceramide, adipocyte

801829
type: SpeciesReference
stoichiometry: 1.0
species: 768359

822939
type: Reaction
reactant: 822951
product: 822975
notes: SUBSYSTEM: Vitamins & Cofactor Biosynthesis
reversible: false
product: 822987
reactant: 822963
kinetic law: 822999
fast: false
name: Formaldehyde activation (spontaneous)

822951
type: SpeciesReference
stoichiometry: 1.0
species: 767428

822975
type: SpeciesReference
stoichiometry: 1.0
species: 767779

822987
type: SpeciesReference
stoichiometry: 1.0
species: 768238

768238
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5,10-Methylenetetrahydrofolate

822963
type: SpeciesReference
stoichiometry: 1.0
species: 769198

823048
type: LocalParameter
value: 500.0

823036
type: LocalParameter
value: 0.0

823023
type: LocalParameter
value: 1000.0

823011
type: LocalParameter
value: 0.0

789607
type: Reaction
reactant: 789631
product: 789667
kinetic law: 789703
fast: false
name: Citrate lyase (ATP-requiring)
notes: GENE_ASSOCIATION: (NM_198830.1 or NM_001096.2) GENE_LIST: NM_001096.2 NM_198830.1 SUBSYSTEM: Central Metabolism
reversible: false
product: 789691
product: 789655
product: 789679
reactant: 789643
reactant: 789619

789631
type: SpeciesReference
stoichiometry: 1.0
species: 766556

789667
type: SpeciesReference
stoichiometry: 1.0
species: 766240

789752
type: LocalParameter
value: 500.0

789740
type: LocalParameter
value: 0.0

789728
type: LocalParameter
value: 1000.0

789716
type: LocalParameter
value: 0.0

789691
type: SpeciesReference
stoichiometry: 1.0
species: 768800

789655
type: SpeciesReference
stoichiometry: 1.0
species: 766204

789679
type: SpeciesReference
stoichiometry: 1.0
species: 768385

789643
type: SpeciesReference
stoichiometry: 1.0
species: 766616

789619
type: SpeciesReference
stoichiometry: 1.0
species: 766398

781129
type: Reaction
product: 781190
fast: false
reactant: 781153
reversible: false
kinetic law: 781214
name: acetyl-CoA synthetase
reactant: 781165
product: 781202
reactant: 781141
notes: GENE_ASSOCIATION: NM_032501.2 GENE_LIST: NM_032501.2 SUBSYSTEM: Pyruvate Metabolism
product: 781178

781190
type: SpeciesReference
stoichiometry: 1.0
species: 769706

781153
type: SpeciesReference
stoichiometry: 1.0
species: 769730

781262
type: LocalParameter
value: 500.0

781250
type: LocalParameter
value: 0.0

781238
type: LocalParameter
value: 1000.0

781226
type: LocalParameter
value: 0.0

781165
type: SpeciesReference
stoichiometry: 1.0
species: 769851

781202
type: SpeciesReference
stoichiometry: 1.0
species: 771046

781141
type: SpeciesReference
stoichiometry: 1.0
species: 769633

781178
type: SpeciesReference
stoichiometry: 1.0
species: 769657

788662
type: Reaction
product: 788710
product: 788698
notes: GENE_ASSOCIATION: NM_024419.3 GENE_LIST: NM_024419.3 SUBSYSTEM: Phospholipid Metabolism
reactant: 788686
name: CDP-diacylglycerol--serine O-phosphatidyltransferae, mitochondrial, human adipoctye
reversible: true
reactant: 788674
kinetic law: 788734
fast: false
product: 788722

788710
type: SpeciesReference
stoichiometry: 1.0
species: 770333

788698
type: SpeciesReference
stoichiometry: 1.0
species: 769827

788686
type: SpeciesReference
stoichiometry: 1.0
species: 770309

788674
type: SpeciesReference
stoichiometry: 0.001
species: 769778

769778
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: CDPdiacylglycerol, human adipocyte

788782
type: LocalParameter
value: 0.0

788770
type: LocalParameter
value: 0.0

788758
type: LocalParameter
value: 1000.0

788746
type: LocalParameter
value: -1000.0

788722
type: SpeciesReference
stoichiometry: 0.001
species: 770973

807126
type: Reaction
kinetic law: 807163
product: 807151
reactant: 807139
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ethanol transport in/out via diffusion

807211
type: LocalParameter
value: 0.0

807199
type: LocalParameter
value: 0.0

807187
type: LocalParameter
value: 1000.0

807175
type: LocalParameter
value: -1000.0

807151
type: SpeciesReference
stoichiometry: 1.0
species: 765321

807139
type: SpeciesReference
stoichiometry: 1.0
species: 767331

771996
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: ecsea9_b

806911
type: Reaction
kinetic law: 806950
product: 806937
reactant: 806924
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Eicosatetraenoate (C20:4, n-6) transport

807003
type: LocalParameter
value: 0.0

806990
type: LocalParameter
value: 0.0

806977
type: LocalParameter
value: 1000.0

806964
type: LocalParameter
value: -1000.0

806937
type: SpeciesReference
stoichiometry: 1.0
species: 767202

806924
type: SpeciesReference
stoichiometry: 1.0
species: 765309

771240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 4,4-dimethylcholesta-8,14,24-trienol

849198
type: Reaction
notes: GENE_ASSOCIATION: NM_014338.3 GENE_LIST: NM_014338.3 SUBSYSTEM: Phospholipid Metabolism
product: 849246
reactant: 849210
reactant: 849222
fast: false
name: phosphatidylserine decarboxylase, human adipocyte
product: 849234
reversible: false
kinetic law: 849258

849246
type: SpeciesReference
stoichiometry: 0.001
species: 768763

768763
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: phosphatidylethanolamine, human adipoctye

849210
type: SpeciesReference
stoichiometry: 1.0
species: 767767

849222
type: SpeciesReference
stoichiometry: 0.001
species: 768945

768945
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Phosphatidylserine, human adipocyte

849234
type: SpeciesReference
stoichiometry: 1.0
species: 766604

849307
type: LocalParameter
value: 500.0

849294
type: LocalParameter
value: 0.0

849282
type: LocalParameter
value: 1000.0

849270
type: LocalParameter
value: 0.0

766568
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Citrulline

852379
type: Reaction
product: 852464
reversible: false
product: 852440
fast: false
product: 852452
reactant: 852404
kinetic law: 852476
reactant: 852391
name: Squalene epoxidase, endoplasmic reticular
reactant: 852416
notes: GENE_ASSOCIATION: NM_003129.3 GENE_LIST: NM_003129.3 SUBSYSTEM: Cholesterol Metabolism
reactant: 852428

852464
type: SpeciesReference
stoichiometry: 1.0
species: 771516

852440
type: SpeciesReference
stoichiometry: 1.0
species: 771324

771324
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: (S)-Squalene-2,3-epoxide

852452
type: SpeciesReference
stoichiometry: 1.0
species: 771456

852404
type: SpeciesReference
stoichiometry: 1.0
species: 771528

852524
type: LocalParameter
value: 500.0

852512
type: LocalParameter
value: 0.0

852500
type: LocalParameter
value: 1000.0

852488
type: LocalParameter
value: 0.0

852391
type: SpeciesReference
stoichiometry: 1.0
species: 771444

852416
type: SpeciesReference
stoichiometry: 1.0
species: 771540

852428
type: SpeciesReference
stoichiometry: 1.0
species: 771576

835543
type: Reaction
product: 835591
fast: false
reversible: false
reactant: 835555
kinetic law: 835603
name: 3-mercaptopyruvate sulfurtransferase
notes: GENE_ASSOCIATION: (NM_001013440.1 or NM_001013436.1 or NM_021126.4) GENE_LIST: NM_001013436.1 NM_001013440.1 NM_021126.4 SUBSYSTEM: Cysteine Metabolism
product: 835579
reactant: 835567

835591
type: SpeciesReference
stoichiometry: 1.0
species: 769282

835555
type: SpeciesReference
stoichiometry: 1.0
species: 768166

835652
type: LocalParameter
value: 500.0

835641
type: LocalParameter
value: 0.0

835627
type: LocalParameter
value: 1000.0

835615
type: LocalParameter
value: 0.0

835579
type: SpeciesReference
stoichiometry: 1.0
species: 768981

835567
type: SpeciesReference
stoichiometry: 1.0
species: 769053

773844
type: Reaction
kinetic law: 773881
product: 773869
reactant: 773857
fast: false
reversible: true
name: L-Cysteine exchange

773929
type: LocalParameter
value: 500.0

773917
type: LocalParameter
value: 0.0

773905
type: LocalParameter
value: 1000.0

773893
type: LocalParameter
value: 0.0

773869
type: SpeciesReference
stoichiometry: 1.0
species: 771912

771912
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: cys_L_b

773857
type: SpeciesReference
stoichiometry: 1.0
species: 765201

840426
type: Reaction
product: 840475
reactant: 840451
notes: GENE_ASSOCIATION: ((NM_000269.2 and NM_001018137.1) or (NM_001018137.1 and NM_198175.1) or NM_002513.2 or NM_005793.3 or NM_013330.3 or (NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_002512.2) or (NM_001018139.1 and NM_198175.1) or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_001018138.1 and NM_198175.1) or NM_197972.1) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
product: 840463
fast: false
name: nucleoside-diphosphate kinase (ATP:dGDP)
kinetic law: 840487
reactant: 840438
reversible: true

840475
type: SpeciesReference
stoichiometry: 1.0
species: 766883

766883
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dGTP

840451
type: SpeciesReference
stoichiometry: 1.0
species: 766871

840463
type: SpeciesReference
stoichiometry: 1.0
species: 766240

840535
type: LocalParameter
value: 0.0

840523
type: LocalParameter
value: 0.0

840511
type: LocalParameter
value: 1000.0

840499
type: LocalParameter
value: -1000.0

840438
type: SpeciesReference
stoichiometry: 1.0
species: 766398

854692
type: Reaction
product: 854753
reactant: 854704
name: thioredoxin reductase (NADPH)
reactant: 854716
notes: GENE_ASSOCIATION: (NM_182729.1 or NM_003330.2 or NM_182742.1 or NM_182743.1 or NM_001093771.1) GENE_LIST: NM_001093771.1 NM_003330.2 NM_182729.1 NM_182742.1 NM_182743.1 SUBSYSTEM: Tyrosine metabolism
reactant: 854728
fast: false
reversible: true
kinetic law: 854766
product: 854740

854753
type: SpeciesReference
stoichiometry: 1.0
species: 769246

769246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Reduced thioredoxin

854704
type: SpeciesReference
stoichiometry: 1.0
species: 767767

854716
type: SpeciesReference
stoichiometry: 1.0
species: 768335

854728
type: SpeciesReference
stoichiometry: 1.0
species: 769234

854814
type: LocalParameter
value: 0.0

854802
type: LocalParameter
value: 0.0

854790
type: LocalParameter
value: 1000.0

854778
type: LocalParameter
value: -1000.0

854740
type: SpeciesReference
stoichiometry: 1.0
species: 768323

855529
type: Reaction
reactant: 855541
product: 855566
reversible: true
product: 855578
notes: GENE_ASSOCIATION: NM_002079.1 GENE_LIST: NM_002079.1 SUBSYSTEM: Tyrosine metabolism
fast: false
reactant: 855553
kinetic law: 855590
name: tyrosine transaminase

855541
type: SpeciesReference
stoichiometry: 1.0
species: 766300

855566
type: SpeciesReference
stoichiometry: 1.0
species: 765950

855578
type: SpeciesReference
stoichiometry: 1.0
species: 767633

855553
type: SpeciesReference
stoichiometry: 1.0
species: 769318

855639
type: LocalParameter
value: 0.0

855627
type: LocalParameter
value: 0.0

855615
type: LocalParameter
value: 1000.0

855603
type: LocalParameter
value: -1000.0

840062
type: Reaction
reversible: true
name: nucleoside-diphosphate kinase (ATP:CDP)
notes: GENE_ASSOCIATION: ((NM_001018137.1 and NM_198175.1) or NM_197972.1 or NM_005793.3 or NM_013330.3 or (NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_001018139.1) or (NM_001018138.1 and NM_198175.1) or (NM_001018139.1 and NM_198175.1) or NM_002513.2 or (NM_000269.2 and NM_001018137.1) or (NM_000269.2 and NM_002512.2) or (NM_002512.2 and NM_198175.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 840074
fast: false
reactant: 840086
product: 840110
product: 840098
kinetic law: 840122

840074
type: SpeciesReference
stoichiometry: 1.0
species: 766398

840086
type: SpeciesReference
stoichiometry: 1.0
species: 766458

840110
type: SpeciesReference
stoichiometry: 1.0
species: 766640

840098
type: SpeciesReference
stoichiometry: 1.0
species: 766240

840171
type: LocalParameter
value: 0.0

840159
type: LocalParameter
value: 0.0

840146
type: LocalParameter
value: 1000.0

840134
type: LocalParameter
value: -1000.0

800515
type: Reaction
product: 800564
name: cystathionine b-synthase
reversible: false
product: 800552
kinetic law: 800576
fast: false
reactant: 800540
reactant: 800527
notes: GENE_ASSOCIATION: NM_000071.1 GENE_LIST: NM_000071.1 SUBSYSTEM: Cysteine Metabolism

800564
type: SpeciesReference
stoichiometry: 1.0
species: 767779

800552
type: SpeciesReference
stoichiometry: 1.0
species: 766664

766664
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Cystathionine

800624
type: LocalParameter
value: 500.0

800612
type: LocalParameter
value: 0.0

800600
type: LocalParameter
value: 1000.0

800588
type: LocalParameter
value: 0.0

800540
type: SpeciesReference
stoichiometry: 1.0
species: 769041

800527
type: SpeciesReference
stoichiometry: 1.0
species: 767815

772165
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: hdcea7_b

768569
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoyl-CoA (C18:1CoA, n-7)

809970
type: Reaction
reactant: 809983
product: 810019
name: fatty-acid--CoA ligase (eicosatrienoate, C20:3 n-6), hepatocyte
product: 810031
reversible: true
kinetic law: 810055
reactant: 810007
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203380.1 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203379.1 or NM_001009185.1 or NM_015256.2 or NM_016234.3) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
fast: false
reactant: 809995
product: 810043

809983
type: SpeciesReference
stoichiometry: 1.0
species: 766398

810019
type: SpeciesReference
stoichiometry: 1.0
species: 766338

810031
type: SpeciesReference
stoichiometry: 1.0
species: 767306

810103
type: LocalParameter
value: 0.0

810091
type: LocalParameter
value: 0.0

810079
type: LocalParameter
value: 1000.0

810067
type: LocalParameter
value: -1000.0

810007
type: SpeciesReference
stoichiometry: 1.0
species: 767189

809995
type: SpeciesReference
stoichiometry: 1.0
species: 766616

810043
type: SpeciesReference
stoichiometry: 1.0
species: 768885

855286
type: Reaction
kinetic law: 855322
product: 855310
reactant: 855298
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: tetradecenoate (C14:1, n-5) transport

855371
type: LocalParameter
value: 0.0

855359
type: LocalParameter
value: 0.0

855346
type: LocalParameter
value: 1000.0

855334
type: LocalParameter
value: -1000.0

855310
type: SpeciesReference
stoichiometry: 1.0
species: 765816

855298
type: SpeciesReference
stoichiometry: 1.0
species: 769306

854473
type: Reaction
kinetic law: 854534
product: 854509
notes: GENE_ASSOCIATION: NM_001071.1 GENE_LIST: NM_001071.1 SUBSYSTEM: Nucleotide Metabolism
name: thymidylate synthase
reversible: true
product: 854522
fast: false
reactant: 854497
reactant: 854485

854582
type: LocalParameter
value: 0.0

854570
type: LocalParameter
value: 0.0

854558
type: LocalParameter
value: 1000.0

854546
type: LocalParameter
value: -1000.0

854509
type: SpeciesReference
stoichiometry: 1.0
species: 766920

766920
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 7,8-Dihydrofolate

854522
type: SpeciesReference
stoichiometry: 1.0
species: 767052

854497
type: SpeciesReference
stoichiometry: 1.0
species: 768238

854485
type: SpeciesReference
stoichiometry: 1.0
species: 767088

827114
type: Reaction
reactant: 827138
kinetic law: 827174
name: L-glutamate:Na+ symporter, blood
product: 827150
reversible: true
notes: GENE_ASSOCIATION: (NM_004170.4 or NM_005071.1 or NM_004172.3 or NM_004171.2 or NM_006671.3) GENE_LIST: NM_004170.4 NM_004171.2 NM_004172.3 NM_005071.1 NM_006671.3 SUBSYSTEM: Transport, Extracellular
product: 827162
reactant: 827126
fast: false

827138
type: SpeciesReference
stoichiometry: 1.0
species: 765575

827222
type: LocalParameter
value: 0.0

827210
type: LocalParameter
value: 0.0

827198
type: LocalParameter
value: 1000.0

827186
type: LocalParameter
value: -1000.0

827150
type: SpeciesReference
stoichiometry: 1.0
species: 767633

827162
type: SpeciesReference
stoichiometry: 1.0
species: 768286

827126
type: SpeciesReference
stoichiometry: 1.0
species: 765369

834048
type: Reaction
reactant: 834060
kinetic law: 834109
product: 834097
fast: false
product: 834084
reversible: true
name: leucine transaminase, mitochondrial
notes: GENE_ASSOCIATION: NM_001190.2 GENE_LIST: NM_001190.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
reactant: 834072

834060
type: SpeciesReference
stoichiometry: 1.0
species: 769693

834158
type: LocalParameter
value: 0.0

834146
type: LocalParameter
value: 0.0

834134
type: LocalParameter
value: 1000.0

834121
type: LocalParameter
value: -1000.0

834097
type: SpeciesReference
stoichiometry: 1.0
species: 770261

834084
type: SpeciesReference
stoichiometry: 1.0
species: 769597

769597
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 4-Methyl-2-oxopentanoate

834072
type: SpeciesReference
stoichiometry: 1.0
species: 770526

770526
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Leucine

769537
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-3-hydroxyisobutyrate

829221
type: Reaction
kinetic law: 829258
product: 829245
reactant: 829233
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: H2O2 transport, peroxisomal

829306
type: LocalParameter
value: 0.0

829294
type: LocalParameter
value: 0.0

829282
type: LocalParameter
value: 1000.0

829270
type: LocalParameter
value: -1000.0

829245
type: SpeciesReference
stoichiometry: 1.0
species: 771744

829233
type: SpeciesReference
stoichiometry: 1.0
species: 767791

799123
type: Reaction
reactant: 799135
product: 799171
kinetic law: 799184
reactant: 799147
reversible: true
notes: SUBSYSTEM: Carnitine Shuttle
name: carnitine O-aceyltransferase, mitochondrial
product: 799159
fast: false

799135
type: SpeciesReference
stoichiometry: 1.0
species: 769851

799171
type: SpeciesReference
stoichiometry: 1.0
species: 771034

799232
type: LocalParameter
value: 0.0

799220
type: LocalParameter
value: 0.0

799208
type: LocalParameter
value: 1000.0

799196
type: LocalParameter
value: -1000.0

799147
type: SpeciesReference
stoichiometry: 1.0
species: 770913

799159
type: SpeciesReference
stoichiometry: 1.0
species: 769863

768046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Isoleucine

769404
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Xanthosine 5'-phosphate

848459
type: Reaction
reactant: 848471
kinetic law: 848544
reversible: false
name: phosphoribosylaminoimidazole synthetase
product: 848495
fast: false
product: 848532
product: 848507
notes: GENE_ASSOCIATION: (NM_175085.1 or NM_000819.3) GENE_LIST: NM_000819.3 NM_175085.1 SUBSYSTEM: Nucleotide Metabolism
reactant: 848483
product: 848520

848471
type: SpeciesReference
stoichiometry: 1.0
species: 766398

848592
type: LocalParameter
value: 500.0

848580
type: LocalParameter
value: 0.0

848568
type: LocalParameter
value: 1000.0

848556
type: LocalParameter
value: 0.0

848495
type: SpeciesReference
stoichiometry: 1.0
species: 766240

848532
type: SpeciesReference
stoichiometry: 1.0
species: 768800

848507
type: SpeciesReference
stoichiometry: 1.0
species: 766288

848483
type: SpeciesReference
stoichiometry: 1.0
species: 767500

848520
type: SpeciesReference
stoichiometry: 1.0
species: 767767

765273
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: eicosenoate (C20:1, n-11)

826896
type: Reaction
kinetic law: 826932
product: 826920
reactant: 826908
notes: SUBSYSTEM: Proline Biosynthesis
fast: false
reversible: true
name: L-Glutamate 5-semialdehyde transport, mitochondrial

826981
type: LocalParameter
value: 0.0

826969
type: LocalParameter
value: 0.0

826957
type: LocalParameter
value: 1000.0

826944
type: LocalParameter
value: -1000.0

826920
type: SpeciesReference
stoichiometry: 1.0
species: 770285

826908
type: SpeciesReference
stoichiometry: 1.0
species: 767645

773265
type: Reaction
kinetic law: 773301
product: 773289
reactant: 773277
fast: false
reversible: true
name: L-Alanine exchange

773349
type: LocalParameter
value: 500.0

773337
type: LocalParameter
value: 0.0

773325
type: LocalParameter
value: 1000.0

773313
type: LocalParameter
value: 0.0

773289
type: SpeciesReference
stoichiometry: 1.0
species: 771840

773277
type: SpeciesReference
stoichiometry: 1.0
species: 765129

765129
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Alanine

765587
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Ammonium

822708
type: Reaction
kinetic law: 822756
product: 822744
reactant: 822732
reactant: 822720
notes: GENE_ASSOCIATION: NM_000143.2 GENE_LIST: NM_000143.2 SUBSYSTEM: Citrate Cycle (TCA)
fast: false
reversible: true
name: fumarase, mitochondrial

822804
type: LocalParameter
value: 0.0

822792
type: LocalParameter
value: 0.0

822780
type: LocalParameter
value: 1000.0

822768
type: LocalParameter
value: -1000.0

822744
type: SpeciesReference
stoichiometry: 1.0
species: 770538

822732
type: SpeciesReference
stoichiometry: 1.0
species: 770345

822720
type: SpeciesReference
stoichiometry: 1.0
species: 770225

798638
type: Reaction
name: tetradecenoyl carnitine transport (C14:1Crn, n5)
fast: false
reactant: 798662
reversible: true
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
product: 798674
product: 798686
kinetic law: 798698
reactant: 798650

798662
type: SpeciesReference
stoichiometry: 1.0
species: 769863

798674
type: SpeciesReference
stoichiometry: 1.0
species: 766628

798686
type: SpeciesReference
stoichiometry: 1.0
species: 771180

798746
type: LocalParameter
value: 0.0

798734
type: LocalParameter
value: 0.0

798722
type: LocalParameter
value: 1000.0

798710
type: LocalParameter
value: -1000.0

798650
type: SpeciesReference
stoichiometry: 1.0
species: 769174

769174
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: tetradecenoyl carnitine (C14:1Crn, n-5)

767719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Geranyl diphosphate

765454
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: hexadecenoate (C16:1, n-7)

796579
type: Reaction
name: octadecatrienoyl carnitine transferase (C18:3Crn, n3)
reactant: 796591
product: 796629
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 796641
fast: false
product: 796616
reactant: 796603
reversible: true

796591
type: SpeciesReference
stoichiometry: 1.0
species: 768544

768544
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecatrienoyl carnitine (C18:3Crn, n3)

796629
type: SpeciesReference
stoichiometry: 1.0
species: 770780

796689
type: LocalParameter
value: 0.0

796677
type: LocalParameter
value: 0.0

796665
type: LocalParameter
value: 1000.0

796653
type: LocalParameter
value: -1000.0

796616
type: SpeciesReference
stoichiometry: 1.0
species: 766628

796603
type: SpeciesReference
stoichiometry: 1.0
species: 769863

832840
type: Reaction
kinetic law: 832878
product: 832866
reactant: 832853
notes: GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-isoleucine transport via diffusion, blood

832926
type: LocalParameter
value: 0.0

832914
type: LocalParameter
value: 0.0

832902
type: LocalParameter
value: 1000.0

832890
type: LocalParameter
value: -1000.0

832866
type: SpeciesReference
stoichiometry: 1.0
species: 768046

832853
type: SpeciesReference
stoichiometry: 1.0
species: 765515

765515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: L-Isoleucine

816766
type: Reaction
product: 816874
reactant: 816814
reversible: false
kinetic law: 816886
reactant: 816802
reactant: 816778
product: 816838
product: 816850
name: Beta oxidation of fatty acid
reactant: 816826
fast: false
reactant: 816790
product: 816862
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation

816874
type: SpeciesReference
stoichiometry: 10.0
species: 770634

816814
type: SpeciesReference
stoichiometry: 10.0
species: 770622

816934
type: LocalParameter
value: 500.0

816922
type: LocalParameter
value: 0.0

816910
type: LocalParameter
value: 1000.0

816898
type: LocalParameter
value: 0.0

816802
type: SpeciesReference
stoichiometry: 10.0
species: 770345

816778
type: SpeciesReference
stoichiometry: 10.0
species: 769851

816838
type: SpeciesReference
stoichiometry: 11.0
species: 769657

816850
type: SpeciesReference
stoichiometry: 6.0
species: 770165

816826
type: SpeciesReference
stoichiometry: 1.0
species: 770877

816790
type: SpeciesReference
stoichiometry: 6.0
species: 770153

816862
type: SpeciesReference
stoichiometry: 10.0
species: 770333

821102
type: Reaction
fast: false
reactant: 821128
kinetic law: 821167
reactant: 821115
product: 821154
reversible: false
notes: GENE_ASSOCIATION: (NM_000507.2 or NM_003837.2) GENE_LIST: NM_000507.2 NM_003837.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 821141
name: fructose-bisphosphatase

821128
type: SpeciesReference
stoichiometry: 1.0
species: 767779

821218
type: LocalParameter
value: 500.0

821206
type: LocalParameter
value: 0.0

821193
type: LocalParameter
value: 1000.0

821180
type: LocalParameter
value: 0.0

821115
type: SpeciesReference
stoichiometry: 1.0
species: 767440

767440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: D-Fructose 1,6-bisphosphate

821154
type: SpeciesReference
stoichiometry: 1.0
species: 768800

821141
type: SpeciesReference
stoichiometry: 1.0
species: 767392

768226
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 1D-myo-Inositol 1-phosphate

828509
type: Reaction
notes: GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 828533
reactant: 828521
product: 828558
reversible: false
fast: false
name: geranyltranstransferase
kinetic law: 828570
product: 828546

828533
type: SpeciesReference
stoichiometry: 1.0
species: 768082

828521
type: SpeciesReference
stoichiometry: 1.0
species: 767719

828558
type: SpeciesReference
stoichiometry: 1.0
species: 768885

828619
type: LocalParameter
value: 500.0

828607
type: LocalParameter
value: 0.0

828595
type: LocalParameter
value: 1000.0

828582
type: LocalParameter
value: 0.0

828546
type: SpeciesReference
stoichiometry: 1.0
species: 767524

820255
type: Reaction
reactant: 820279
product: 820327
reactant: 820267
name: fatty acid synthase (n-C6:0)
product: 820339
reactant: 820303
reversible: false
product: 820364
reactant: 820291
product: 820315
product: 820351
kinetic law: 820376
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
fast: false

820279
type: SpeciesReference
stoichiometry: 3.0
species: 767767

820327
type: SpeciesReference
stoichiometry: 1.0
species: 766616

820267
type: SpeciesReference
stoichiometry: 1.0
species: 766410

820339
type: SpeciesReference
stoichiometry: 1.0
species: 767779

820303
type: SpeciesReference
stoichiometry: 2.0
species: 768335

820364
type: SpeciesReference
stoichiometry: 2.0
species: 768323

820291
type: SpeciesReference
stoichiometry: 1.0
species: 768154

820315
type: SpeciesReference
stoichiometry: 1.0
species: 766604

820351
type: SpeciesReference
stoichiometry: 1.0
species: 768009

820424
type: LocalParameter
value: 500.0

820412
type: LocalParameter
value: 0.0

820400
type: LocalParameter
value: 1000.0

820388
type: LocalParameter
value: 0.0

769669
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: O-Acetylcarnitine

771384
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Desmosterol

789510
type: Reaction
kinetic law: 789546
product: 789534
reactant: 789522
notes: GENE_ASSOCIATION: NM_006579.1 GENE_LIST: NM_006579.1 SUBSYSTEM: Cholesterol Biosynthesis
fast: false
reversible: true
name: cholestenol delta-isomerase

789595
type: LocalParameter
value: 0.0

789583
type: LocalParameter
value: 0.0

789571
type: LocalParameter
value: 1000.0

789558
type: LocalParameter
value: -1000.0

789534
type: SpeciesReference
stoichiometry: 1.0
species: 771336

789522
type: SpeciesReference
stoichiometry: 1.0
species: 771600

808092
type: Reaction
reactant: 808128
product: 808140
reversible: true
name: fatty-acid--CoA ligase (hexadecenoate, C16:1 n-9)
reactant: 808104
fast: false
kinetic law: 808176
product: 808164
product: 808152
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203380.1 or NM_004458.1 or NM_016234.3 or NM_001995.2 or NM_004457.3 or NM_022977.1 or NM_203379.1) GENE_LIST: NM_001995.2 NM_004457.3 NM_004458.1 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reactant: 808116

808128
type: SpeciesReference
stoichiometry: 1.0
species: 767851

808140
type: SpeciesReference
stoichiometry: 1.0
species: 766338

808104
type: SpeciesReference
stoichiometry: 1.0
species: 766398

808225
type: LocalParameter
value: 0.0

808213
type: LocalParameter
value: 0.0

808201
type: LocalParameter
value: 1000.0

808188
type: LocalParameter
value: -1000.0

808164
type: SpeciesReference
stoichiometry: 1.0
species: 768885

808152
type: SpeciesReference
stoichiometry: 1.0
species: 767876

808116
type: SpeciesReference
stoichiometry: 1.0
species: 766616

786459
type: Reaction
notes: SUBSYSTEM: Other
reversible: false
fast: false
reactant: 786471
product: 786507
product: 786495
kinetic law: 786531
reactant: 786483
product: 786519
name: ATP maintenance requirment

786471
type: SpeciesReference
stoichiometry: 1.0
species: 766398

786507
type: SpeciesReference
stoichiometry: 1.0
species: 767767

786495
type: SpeciesReference
stoichiometry: 1.0
species: 766240

786579
type: LocalParameter
value: 500.0

786567
type: LocalParameter
value: 0.0

786555
type: LocalParameter
value: 1000.0

786543
type: LocalParameter
value: 0.0

786483
type: SpeciesReference
stoichiometry: 1.0
species: 767779

786519
type: SpeciesReference
stoichiometry: 1.0
species: 768800

797792
type: Reaction
reactant: 797804
kinetic law: 797852
product: 797828
name: carnitine propionyltransferase
reversible: true
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reactant: 797816
product: 797840

797804
type: SpeciesReference
stoichiometry: 1.0
species: 766628

797902
type: LocalParameter
value: 0.0

797890
type: LocalParameter
value: 0.0

797877
type: LocalParameter
value: 1000.0

797864
type: LocalParameter
value: -1000.0

797828
type: SpeciesReference
stoichiometry: 1.0
species: 766616

797816
type: SpeciesReference
stoichiometry: 1.0
species: 768873

797840
type: SpeciesReference
stoichiometry: 1.0
species: 768726

839942
type: Reaction
reactant: 839966
notes: GENE_ASSOCIATION: (NM_013330.3 or NM_197972.1 or NM_002513.2 or NM_005793.3 or (NM_000269.2 and NM_002512.2) or (NM_001018138.1 and NM_198175.1) or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_001018139.1) or (NM_001018139.1 and NM_198175.1) or (NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1)) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
kinetic law: 840002
reversible: true
name: nucleoside-diphosphate kinase (ATP:UDP)
reactant: 839954
fast: false
product: 839978
product: 839990

839966
type: SpeciesReference
stoichiometry: 1.0
species: 769330

769330
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: UDP

840050
type: LocalParameter
value: 0.0

840038
type: LocalParameter
value: 0.0

840026
type: LocalParameter
value: 1000.0

840014
type: LocalParameter
value: -1000.0

839954
type: SpeciesReference
stoichiometry: 1.0
species: 766398

839978
type: SpeciesReference
stoichiometry: 1.0
species: 766240

839990
type: SpeciesReference
stoichiometry: 1.0
species: 769379

801515
type: Reaction
reactant: 801527
reactant: 801552
reversible: true
product: 801576
product: 801564
notes: GENE_ASSOCIATION: NM_001263.2 GENE_LIST: NM_001263.2 SUBSYSTEM: Phospholipid Metabolism
kinetic law: 801588
reactant: 801539
name: CDP-Diacylglycerol synthetase, human adipocyte
fast: false

801527
type: SpeciesReference
stoichiometry: 1.0
species: 766640

801552
type: SpeciesReference
stoichiometry: 0.001
species: 768690

801576
type: SpeciesReference
stoichiometry: 1.0
species: 768885

801564
type: SpeciesReference
stoichiometry: 0.001
species: 766482

801636
type: LocalParameter
value: 0.0

801624
type: LocalParameter
value: 0.0

801612
type: LocalParameter
value: 1000.0

801600
type: LocalParameter
value: -1000.0

801539
type: SpeciesReference
stoichiometry: 1.0
species: 767767

793791
type: Reaction
notes: GENE_ASSOCIATION: (NM_152359.1 or NM_004377.2 or NM_152246.1 or NM_001031847.1 or NM_152245.1 or NM_001876.2 or NM_152247.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 793827
reactant: 793815
reactant: 793803
reversible: true
fast: false
kinetic law: 793851
product: 793839
name: carnitine eicosanoyltransferase (C20:0Crn)

793827
type: SpeciesReference
stoichiometry: 1.0
species: 766616

793815
type: SpeciesReference
stoichiometry: 1.0
species: 767125

793803
type: SpeciesReference
stoichiometry: 1.0
species: 766628

793899
type: LocalParameter
value: 0.0

793887
type: LocalParameter
value: 0.0

793875
type: LocalParameter
value: 1000.0

793863
type: LocalParameter
value: -1000.0

793839
type: SpeciesReference
stoichiometry: 1.0
species: 767138

767138
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosanoylcarnitine, C20:0crn

827731
type: Reaction
kinetic law: 827804
fast: false
notes: GENE_ASSOCIATION: (NM_203391.1 or NM_000167.3 or NM_033214.2) GENE_LIST: NM_000167.3 NM_033214.2 NM_203391.1 SUBSYSTEM: Glycerophospholipid Metabolism
name: glycerol kinase
reactant: 827743
product: 827768
reversible: false
reactant: 827756
product: 827780
product: 827792

827853
type: LocalParameter
value: 500.0

827841
type: LocalParameter
value: 0.0

827829
type: LocalParameter
value: 1000.0

827817
type: LocalParameter
value: 0.0

827743
type: SpeciesReference
stoichiometry: 1.0
species: 766398

827768
type: SpeciesReference
stoichiometry: 1.0
species: 766240

827756
type: SpeciesReference
stoichiometry: 1.0
species: 767670

827780
type: SpeciesReference
stoichiometry: 1.0
species: 767683

827792
type: SpeciesReference
stoichiometry: 1.0
species: 767767

825595
type: Reaction
kinetic law: 825631
product: 825619
reactant: 825607
notes: GENE_ASSOCIATION: (NM_207420.1 or NM_020041.2 or NM_001024938.1 or NM_001024939.1 or NM_030807.2 or NM_145176.2 or NM_000340.1 or NM_006931.1 or NM_006516.1 or NM_017585.2 or NM_001042.2 or NM_030777.3 or NM_014580.3 or NM_153449.2 or NM_001001290.1) GENE_LIST: NM_000340.1 NM_001001290.1 NM_001024938.1 NM_001024939.1 NM_001042.2 NM_006516.1 NM_006931.1 NM_014580.3 NM_017585.2 NM_020041.2 NM_030777.3 NM_030807.2 NM_145176.2 NM_153449.2 NM_207420.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: glucose transport (uniport: facilitated diffusion)

825679
type: LocalParameter
value: 0.0

825667
type: LocalParameter
value: 0.0

825655
type: LocalParameter
value: 1000.0

825643
type: LocalParameter
value: -1000.0

825619
type: SpeciesReference
stoichiometry: 1.0
species: 767609

825607
type: SpeciesReference
stoichiometry: 1.0
species: 765345

765345
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: D-Glucose

795364
type: Reaction
fast: false
reactant: 795377
reactant: 795389
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
name: carnitine octadecenoyltransferase (C18:1Crn, n7), mitochondrial
kinetic law: 795426
reversible: true
product: 795401
product: 795413

795377
type: SpeciesReference
stoichiometry: 1.0
species: 769863

795389
type: SpeciesReference
stoichiometry: 1.0
species: 770805

770805
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl-CoA (C18:1CoA, n-7)

795475
type: LocalParameter
value: 0.0

795463
type: LocalParameter
value: 0.0

795450
type: LocalParameter
value: 1000.0

795438
type: LocalParameter
value: -1000.0

795401
type: SpeciesReference
stoichiometry: 1.0
species: 769851

795413
type: SpeciesReference
stoichiometry: 1.0
species: 770841

770841
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecenoyl carnitine (C18:1Crn, n7)

842856
type: Reaction
name: ornithine transaminase, mitochondrial
fast: false
reversible: true
kinetic law: 842916
reactant: 842868
product: 842892
reactant: 842880
product: 842904
notes: GENE_ASSOCIATION: NM_000274.1 GENE_LIST: NM_000274.1 SUBSYSTEM: Arginine and Proline Metabolism

842965
type: LocalParameter
value: 0.0

842952
type: LocalParameter
value: 0.0

842940
type: LocalParameter
value: 1000.0

842928
type: LocalParameter
value: -1000.0

842868
type: SpeciesReference
stoichiometry: 1.0
species: 769693

842892
type: SpeciesReference
stoichiometry: 1.0
species: 770261

842880
type: SpeciesReference
stoichiometry: 1.0
species: 770865

770865
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: L-Ornithine

842904
type: SpeciesReference
stoichiometry: 1.0
species: 770285

795729
type: Reaction
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 795753
reversible: true
name: carnitine octadecenoyltransferase (C18:1Crn, n9), mitochondrial
product: 795777
product: 795765
fast: false
kinetic law: 795789
reactant: 795741

795753
type: SpeciesReference
stoichiometry: 1.0
species: 770817

795777
type: SpeciesReference
stoichiometry: 1.0
species: 770853

795765
type: SpeciesReference
stoichiometry: 1.0
species: 769851

795837
type: LocalParameter
value: 0.0

795825
type: LocalParameter
value: 0.0

795813
type: LocalParameter
value: 1000.0

795801
type: LocalParameter
value: -1000.0

795741
type: SpeciesReference
stoichiometry: 1.0
species: 769863

778005
type: Reaction
kinetic law: 778041
product: 778029
reactant: 778017
fast: false
reversible: true
name: (R)-Pantothenate exchange

778089
type: LocalParameter
value: 500.0

778077
type: LocalParameter
value: 0.0

778065
type: LocalParameter
value: 1000.0

778053
type: LocalParameter
value: 0.0

778029
type: SpeciesReference
stoichiometry: 1.0
species: 772430

772430
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: pnto_R_b

778017
type: SpeciesReference
stoichiometry: 1.0
species: 765720

770901
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Phosphatidate, adipocyte

781733
type: Reaction
kinetic law: 781781
product: 781769
product: 781757
reactant: 781745
notes: GENE_ASSOCIATION: (NM_139247.2 or NM_183357.1 or NM_001115.1 or NM_018417.2 or NM_004036.2 or NM_020983.2 or NM_015270.2 or NM_001116.2 or NM_021116.1 or NM_020546.1 or NM_001114.2) GENE_LIST: NM_001114.2 NM_001115.1 NM_001116.2 NM_004036.2 NM_015270.2 NM_018417.2 NM_020546.1 NM_020983.2 NM_021116.1 NM_139247.2 NM_183357.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: false
name: adenylate cyclase

781830
type: LocalParameter
value: 500.0

781817
type: LocalParameter
value: 0.0

781805
type: LocalParameter
value: 1000.0

781793
type: LocalParameter
value: 0.0

781769
type: SpeciesReference
stoichiometry: 1.0
species: 768885

781757
type: SpeciesReference
stoichiometry: 1.0
species: 766422

766422
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: cAMP

781745
type: SpeciesReference
stoichiometry: 1.0
species: 766398

796822
type: Reaction
reactant: 796835
reversible: true
kinetic law: 796883
reactant: 796847
name: carnitine ocosatetraenoyltransferase (C22:4Crn, n6), mitochondrial
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
product: 796871
product: 796859
fast: false

796835
type: SpeciesReference
stoichiometry: 1.0
species: 769863

796932
type: LocalParameter
value: 0.0

796919
type: LocalParameter
value: 0.0

796907
type: LocalParameter
value: 1000.0

796895
type: LocalParameter
value: -1000.0

796847
type: SpeciesReference
stoichiometry: 1.0
species: 770877

796871
type: SpeciesReference
stoichiometry: 1.0
species: 770889

796859
type: SpeciesReference
stoichiometry: 1.0
species: 769851

849900
type: Reaction
reactant: 849924
fast: false
notes: GENE_ASSOCIATION: (NM_001042530.1 or NM_001042532.1 or NM_001042531.1 or NM_025233.4 or NM_001042529.1) GENE_LIST: NM_001042529.1 NM_001042530.1 NM_001042531.1 NM_001042532.1 NM_025233.4 SUBSYSTEM: CoA Biosynthesis
reactant: 849912
reversible: true
reactant: 849936
kinetic law: 849972
name: pantetheine-phosphate adenylyltransferase
product: 849948
product: 849960

849924
type: SpeciesReference
stoichiometry: 1.0
species: 767767

849912
type: SpeciesReference
stoichiometry: 1.0
species: 766398

849936
type: SpeciesReference
stoichiometry: 1.0
species: 768702

850020
type: LocalParameter
value: 0.0

850008
type: LocalParameter
value: 0.0

849996
type: LocalParameter
value: 1000.0

849984
type: LocalParameter
value: -1000.0

849948
type: SpeciesReference
stoichiometry: 1.0
species: 766956

766956
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Dephospho-CoA

849960
type: SpeciesReference
stoichiometry: 1.0
species: 768885

835796
type: Reaction
product: 835844
fast: false
kinetic law: 835868
notes: GENE_ASSOCIATION: NM_005918.2 GENE_LIST: NM_005918.2 SUBSYSTEM: Citrate Cycle (TCA)
name: malate dehydrogenase, mitochondrial
reactant: 835808
reversible: true
product: 835832
product: 835856
reactant: 835820

835844
type: SpeciesReference
stoichiometry: 1.0
species: 770634

835917
type: LocalParameter
value: 0.0

835905
type: LocalParameter
value: 0.0

835893
type: LocalParameter
value: 1000.0

835880
type: LocalParameter
value: -1000.0

835808
type: SpeciesReference
stoichiometry: 1.0
species: 770538

835832
type: SpeciesReference
stoichiometry: 1.0
species: 770333

835856
type: SpeciesReference
stoichiometry: 1.0
species: 770719

835820
type: SpeciesReference
stoichiometry: 1.0
species: 770622

850417
type: Reaction
product: 850454
product: 850478
reactant: 850429
name: ribonucleoside-diphosphate reductase (GDP)
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotide Metabolism
reactant: 850442
kinetic law: 850490
reversible: false
fast: false
product: 850466

850454
type: SpeciesReference
stoichiometry: 1.0
species: 766871

850478
type: SpeciesReference
stoichiometry: 1.0
species: 769234

850429
type: SpeciesReference
stoichiometry: 1.0
species: 767597

850442
type: SpeciesReference
stoichiometry: 1.0
species: 769246

850538
type: LocalParameter
value: 500.0

850526
type: LocalParameter
value: 0.0

850514
type: LocalParameter
value: 1000.0

850502
type: LocalParameter
value: 0.0

850466
type: SpeciesReference
stoichiometry: 1.0
species: 767779

801648
type: Reaction
reactant: 801684
name: CDP-Diacylglycerol synthetase, mitochondrial, human adipocyte
fast: false
reversible: true
reactant: 801672
reactant: 801660
product: 801696
kinetic law: 801720
notes: GENE_ASSOCIATION: NM_003818.2 GENE_LIST: NM_003818.2 SUBSYSTEM: Phospholipid Metabolism
product: 801708

801684
type: SpeciesReference
stoichiometry: 0.001
species: 770901

801672
type: SpeciesReference
stoichiometry: 1.0
species: 770333

801660
type: SpeciesReference
stoichiometry: 1.0
species: 769875

801696
type: SpeciesReference
stoichiometry: 0.001
species: 769778

801768
type: LocalParameter
value: 0.0

801756
type: LocalParameter
value: 0.0

801744
type: LocalParameter
value: 1000.0

801732
type: LocalParameter
value: -1000.0

801708
type: SpeciesReference
stoichiometry: 1.0
species: 771046

833601
type: Reaction
reactant: 833650
kinetic law: 833698
product: 833674
product: 833662
product: 833686
reactant: 833626
fast: false
reversible: false
reactant: 833638
reactant: 833614
name: lathosterol oxidase (NAD), endoplasmic reticulum
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis

833650
type: SpeciesReference
stoichiometry: 1.0
species: 771540

833746
type: LocalParameter
value: 500.0

833734
type: LocalParameter
value: 0.0

833722
type: LocalParameter
value: 1000.0

833710
type: LocalParameter
value: 0.0

833674
type: SpeciesReference
stoichiometry: 2.0
species: 771456

833662
type: SpeciesReference
stoichiometry: 1.0
species: 771312

833686
type: SpeciesReference
stoichiometry: 1.0
species: 771492

833626
type: SpeciesReference
stoichiometry: 1.0
species: 771480

771480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Lathosterol

833638
type: SpeciesReference
stoichiometry: 1.0
species: 771504

833614
type: SpeciesReference
stoichiometry: 1.0
species: 771444

768118
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Leucine

795969
type: Reaction
name: carnitine octadecadienoyltransferase (C18:2Crn, n6)
reactant: 795994
kinetic law: 796033
notes: GENE_ASSOCIATION: (NM_001031847.1 or NM_001876.2 or NM_152359.1 or NM_152247.1 or NM_004377.2 or NM_152245.1 or NM_152246.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 796007
product: 796020
fast: false
reactant: 795981
reversible: true

795994
type: SpeciesReference
stoichiometry: 1.0
species: 768470

796081
type: LocalParameter
value: 0.0

796069
type: LocalParameter
value: 0.0

796057
type: LocalParameter
value: 1000.0

796045
type: LocalParameter
value: -1000.0

796007
type: SpeciesReference
stoichiometry: 1.0
species: 766616

796020
type: SpeciesReference
stoichiometry: 1.0
species: 768482

795981
type: SpeciesReference
stoichiometry: 1.0
species: 766628

769428
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: 10-Formyltetrahydrofolate

788382
type: Reaction
kinetic law: 788491
fast: false
reactant: 788418
reactant: 788406
name: carbamoyl-phosphate synthase (ammonia)
product: 788479
product: 788455
reversible: false
reactant: 788430
product: 788467
product: 788443
notes: GENE_ASSOCIATION: (NM_001122633.1 or NM_001122634.1 or NM_001875.2) GENE_LIST: NM_001122633.1 NM_001122634.1 NM_001875.2 SUBSYSTEM: Arginine and Proline Metabolism
reactant: 788394

788541
type: LocalParameter
value: 500.0

788529
type: LocalParameter
value: 0.0

788516
type: LocalParameter
value: 1000.0

788503
type: LocalParameter
value: 0.0

788418
type: SpeciesReference
stoichiometry: 1.0
species: 770345

788406
type: SpeciesReference
stoichiometry: 1.0
species: 769839

788479
type: SpeciesReference
stoichiometry: 1.0
species: 770985

788455
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stoichiometry: 1.0
species: 769754

788430
type: SpeciesReference
stoichiometry: 1.0
species: 770671

788467
type: SpeciesReference
stoichiometry: 3.0
species: 770333

788443
type: SpeciesReference
stoichiometry: 2.0
species: 769681

788394
type: SpeciesReference
stoichiometry: 2.0
species: 769730

796094
type: Reaction
product: 796130
reversible: true
reactant: 796118
kinetic law: 796154
name: carnitine octadecadienoyltransferase (C18:2Crn, n6), mitochondrial
product: 796142
fast: false
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
reactant: 796106

796130
type: SpeciesReference
stoichiometry: 1.0
species: 769851

796118
type: SpeciesReference
stoichiometry: 1.0
species: 770744

796202
type: LocalParameter
value: 0.0

796190
type: LocalParameter
value: 0.0

796178
type: LocalParameter
value: 1000.0

796166
type: LocalParameter
value: -1000.0

796142
type: SpeciesReference
stoichiometry: 1.0
species: 770756

796106
type: SpeciesReference
stoichiometry: 1.0
species: 769863

826749
type: Reaction
product: 826799
product: 826823
product: 826811
name: glutamine phosphoribosyldiphosphate amidotransferase
fast: false
reversible: false
notes: GENE_ASSOCIATION: NM_002703.3 GENE_LIST: NM_002703.3 SUBSYSTEM: Purine and Pyrimidine Biosynthesis
kinetic law: 826835
reactant: 826786
reactant: 826773
reactant: 826761

826799
type: SpeciesReference
stoichiometry: 1.0
species: 767633

826823
type: SpeciesReference
stoichiometry: 1.0
species: 768909

826811
type: SpeciesReference
stoichiometry: 1.0
species: 768885

826884
type: LocalParameter
value: 500.0

826872
type: LocalParameter
value: 0.0

826860
type: LocalParameter
value: 1000.0

826847
type: LocalParameter
value: 0.0

826786
type: SpeciesReference
stoichiometry: 1.0
species: 768933

768933
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Phospho-alpha-D-ribose 1-diphosphate

826773
type: SpeciesReference
stoichiometry: 1.0
species: 767779

826761
type: SpeciesReference
stoichiometry: 1.0
species: 767621

785478
type: Reaction
reactant: 785503
kinetic law: 785552
product: 785527
reversible: true
product: 785539
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Nucleotide Metabolism
reactant: 785490
name: aspartate carbamoyltransferase (reversible)
fast: false
product: 785515

785503
type: SpeciesReference
stoichiometry: 1.0
species: 766446

766446
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Carbamoyl phosphate

785600
type: LocalParameter
value: 0.0

785588
type: LocalParameter
value: 0.0

785576
type: LocalParameter
value: 1000.0

785564
type: LocalParameter
value: -1000.0

785527
type: SpeciesReference
stoichiometry: 1.0
species: 767767

785539
type: SpeciesReference
stoichiometry: 1.0
species: 768800

785490
type: SpeciesReference
stoichiometry: 1.0
species: 766386

785515
type: SpeciesReference
stoichiometry: 1.0
species: 766434

800092
type: Reaction
reactant: 800104
fast: false
product: 800153
kinetic law: 800177
product: 800165
notes: GENE_ASSOCIATION: (MT4512 and MT4513 and MT4514 and NM_001303.2 and (NM_004376.3 or NM_078470.2) and NM_005694.1 and (NM_001861.2 or NM_032609.2) and NM_004255.2 and NM_001862.2 and (NM_005205.2 or NM_004373.2) and (NM_144613.4 or NM_001863.3) and NM_004374.2 and (NM_001865.2 or NM_001864.2) and (NM_001866.2 or NM_130902.1) and NM_001867.2 and (NM_004074.2 or NM_182971.1)) GENE_LIST: MT4512 MT4513 MT4514 NM_001303.2 NM_001861.2 NM_001862.2 NM_001863.3 NM_001864.2 NM_001865.2 NM_001866.2 NM_001867.2 NM_004074.2 NM_004255.2 NM_004373.2 NM_004374.2 NM_004376.3 NM_005205.2 NM_005694.1 NM_032609.2 NM_078470.2 NM_130902.1 NM_144613.4 NM_182971.1 SUBSYSTEM: Oxidative Phosphorylation
product: 800141
name: cytochrome c oxidase (mitochondrial 4 protons/4 cyto)
reversible: false
reactant: 800128
reactant: 800116

800104
type: SpeciesReference
stoichiometry: 4.0
species: 770201

800153
type: SpeciesReference
stoichiometry: 4.0
species: 770189

770189
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Ferricytochrome c

800225
type: LocalParameter
value: 500.0

800213
type: LocalParameter
value: 0.0

800201
type: LocalParameter
value: 1000.0

800189
type: LocalParameter
value: 0.0

800165
type: SpeciesReference
stoichiometry: 2.0
species: 770345

800141
type: SpeciesReference
stoichiometry: 4.0
species: 767767

800128
type: SpeciesReference
stoichiometry: 1.0
species: 770695

770695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: O2

800116
type: SpeciesReference
stoichiometry: 8.0
species: 770333

814023
type: Reaction
name: Beta oxidation of fatty acid
product: 814133
reactant: 814048
reversible: false
product: 814097
reactant: 814072
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000016.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001919... GENE_LIST: NM_000016.2 NM_000018.2 NM_001033859.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_001919... NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
product: 814109
reactant: 814036
reactant: 814085
product: 814121
fast: false
kinetic law: 814145
reactant: 814060

814133
type: SpeciesReference
stoichiometry: 7.0
species: 770634

814048
type: SpeciesReference
stoichiometry: 6.0
species: 770153

814097
type: SpeciesReference
stoichiometry: 8.0
species: 769657

814072
type: SpeciesReference
stoichiometry: 1.0
species: 770381

814109
type: SpeciesReference
stoichiometry: 6.0
species: 770165

814036
type: SpeciesReference
stoichiometry: 7.0
species: 769851

814085
type: SpeciesReference
stoichiometry: 7.0
species: 770622

814121
type: SpeciesReference
stoichiometry: 7.0
species: 770333

814194
type: LocalParameter
value: 500.0

814182
type: LocalParameter
value: 0.0

814170
type: LocalParameter
value: 1000.0

814158
type: LocalParameter
value: 0.0

814060
type: SpeciesReference
stoichiometry: 7.0
species: 770345

844414
type: Reaction
kinetic law: 844486
fast: false
product: 844474
name: phosphofructokinase
product: 844450
notes: GENE_ASSOCIATION: (NM_002626.4 or NM_001002021.1 or NM_000289.3 or NM_002627.3 or (NM_000289.3 and NM_001002021.1) or (NM_000289.3 and NM_002626.4) or (NM_001002021.1 and NM_002627.3) or (NM_002626.4 and NM_002627.3)) GENE_LIST: NM_000289.3 NM_001002021.1 NM_002626.4 NM_002627.3 SUBSYSTEM: Glycolysis/Gluconeogenesis
reversible: false
reactant: 844438
reactant: 844426
product: 844462

844534
type: LocalParameter
value: 500.0

844522
type: LocalParameter
value: 0.0

844510
type: LocalParameter
value: 1000.0

844498
type: LocalParameter
value: 0.0

844474
type: SpeciesReference
stoichiometry: 1.0
species: 767767

844450
type: SpeciesReference
stoichiometry: 1.0
species: 766240

844438
type: SpeciesReference
stoichiometry: 1.0
species: 767392

844426
type: SpeciesReference
stoichiometry: 1.0
species: 766398

844462
type: SpeciesReference
stoichiometry: 1.0
species: 767440

786097
type: Reaction
product: 786145
fast: false
name: L-aspartate transport, blood
reversible: true
notes: GENE_ASSOCIATION: (NM_004171.2 or NM_005071.1 or NM_004170.4 or NM_004172.3) GENE_LIST: NM_004170.4 NM_004171.2 NM_004172.3 NM_005071.1 SUBSYSTEM: Transport, Extracellular
product: 786133
reactant: 786121
reactant: 786109
kinetic law: 786157

786145
type: SpeciesReference
stoichiometry: 1.0
species: 768286

786133
type: SpeciesReference
stoichiometry: 1.0
species: 766386

786121
type: SpeciesReference
stoichiometry: 1.0
species: 765575

786109
type: SpeciesReference
stoichiometry: 1.0
species: 765165

786206
type: LocalParameter
value: 0.0

786193
type: LocalParameter
value: 0.0

786181
type: LocalParameter
value: 1000.0

786169
type: LocalParameter
value: -1000.0

855383
type: Reaction
product: 855444
product: 855432
fast: false
kinetic law: 855468
reactant: 855395
reactant: 855420
reactant: 855408
product: 855456
reversible: false
notes: GENE_ASSOCIATION: (NM_199292.2 or NM_199293.2 or NM_000360.3) GENE_LIST: NM_000360.3 NM_199292.2 NM_199293.2 SUBSYSTEM: Tyrosine metabolism
name: tyrosine 3-monooxygenase

855444
type: SpeciesReference
stoichiometry: 1.0
species: 766908

855432
type: SpeciesReference
stoichiometry: 1.0
species: 766131

855517
type: LocalParameter
value: 500.0

855505
type: LocalParameter
value: 0.0

855493
type: LocalParameter
value: 1000.0

855480
type: LocalParameter
value: 0.0

855395
type: SpeciesReference
stoichiometry: 1.0
species: 768359

855420
type: SpeciesReference
stoichiometry: 1.0
species: 769318

855408
type: SpeciesReference
stoichiometry: 1.0
species: 769186

855456
type: SpeciesReference
stoichiometry: 1.0
species: 767779

844943
type: Reaction
kinetic law: 844979
product: 844967
reactant: 844955
notes: GENE_ASSOCIATION: NM_000175.2 GENE_LIST: NM_000175.2 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: glucose-6-phosphate isomerase

845027
type: LocalParameter
value: 0.0

845015
type: LocalParameter
value: 0.0

845003
type: LocalParameter
value: 1000.0

844991
type: LocalParameter
value: -1000.0

844967
type: SpeciesReference
stoichiometry: 1.0
species: 767392

844955
type: SpeciesReference
stoichiometry: 1.0
species: 767573

818817
type: Reaction
product: 818926
product: 818902
name: fatty acid synthase (n-C14:0)
product: 818878
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty Acid Biosynthesis
kinetic law: 818938
reactant: 818854
reversible: false
product: 818890
fast: false
reactant: 818829
reactant: 818841
reactant: 818866
product: 818914

818926
type: SpeciesReference
stoichiometry: 1.0
species: 769294

818902
type: SpeciesReference
stoichiometry: 1.0
species: 767779

818878
type: SpeciesReference
stoichiometry: 1.0
species: 766604

818986
type: LocalParameter
value: 500.0

818974
type: LocalParameter
value: 0.0

818962
type: LocalParameter
value: 1000.0

818950
type: LocalParameter
value: 0.0

818854
type: SpeciesReference
stoichiometry: 1.0
species: 768154

818890
type: SpeciesReference
stoichiometry: 1.0
species: 766616

818829
type: SpeciesReference
stoichiometry: 1.0
species: 766833

818841
type: SpeciesReference
stoichiometry: 3.0
species: 767767

818866
type: SpeciesReference
stoichiometry: 2.0
species: 768335

818914
type: SpeciesReference
stoichiometry: 2.0
species: 768323

837418
type: Reaction
kinetic law: 837454
product: 837442
reactant: 837430
notes: GENE_ASSOCIATION: (NM_145871.1 or NM_001513.2 or NM_145870.1) GENE_LIST: NM_001513.2 NM_145870.1 NM_145871.1 SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: false
name: maleylacetoacetate isomerase

837502
type: LocalParameter
value: 500.0

837490
type: LocalParameter
value: 0.0

837478
type: LocalParameter
value: 1000.0

837466
type: LocalParameter
value: 0.0

837442
type: SpeciesReference
stoichiometry: 1.0
species: 766010

837430
type: SpeciesReference
stoichiometry: 1.0
species: 766022

799486
type: Reaction
product: 799534
reversible: true
kinetic law: 799546
fast: false
product: 799522
reactant: 799498
name: carnitine O-acetyltransferase
notes: SUBSYSTEM: Transport, Mitochondrial
reactant: 799510

799534
type: SpeciesReference
stoichiometry: 1.0
species: 769863

799594
type: LocalParameter
value: 0.0

799582
type: LocalParameter
value: 0.0

799570
type: LocalParameter
value: 1000.0

799558
type: LocalParameter
value: -1000.0

799522
type: SpeciesReference
stoichiometry: 1.0
species: 769669

799498
type: SpeciesReference
stoichiometry: 1.0
species: 766216

799510
type: SpeciesReference
stoichiometry: 1.0
species: 766628

827234
type: Reaction
kinetic law: 827294
name: glycine C-acetyltransferase, mitochondrial
notes: GENE_ASSOCIATION: NM_014291.2 GENE_LIST: NM_014291.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reversible: true
product: 827270
product: 827282
reactant: 827246
reactant: 827258
fast: false

827342
type: LocalParameter
value: 0.0

827330
type: LocalParameter
value: 0.0

827318
type: LocalParameter
value: 1000.0

827306
type: LocalParameter
value: -1000.0

827270
type: SpeciesReference
stoichiometry: 1.0
species: 769452

827282
type: SpeciesReference
stoichiometry: 1.0
species: 769851

827246
type: SpeciesReference
stoichiometry: 1.0
species: 769657

827258
type: SpeciesReference
stoichiometry: 1.0
species: 770297

856251
type: Reaction
kinetic law: 856287
product: 856275
reactant: 856263
notes: GENE_ASSOCIATION: NM_003627.4 GENE_LIST: NM_003627.4 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-valine transport via diffusion, blood

856335
type: LocalParameter
value: 0.0

856323
type: LocalParameter
value: 0.0

856311
type: LocalParameter
value: 1000.0

856299
type: LocalParameter
value: -1000.0

856275
type: SpeciesReference
stoichiometry: 1.0
species: 769391

769391
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: L-Valine

856263
type: SpeciesReference
stoichiometry: 1.0
species: 765840

811987
type: Reaction
reactant: 812035
product: 812071
product: 812107
product: 812059
product: 812083
reactant: 812023
notes: SUBSYSTEM: Fatty Acid Synthesis
name: fatty-acyl-CoA elongation (C22:4CoA, n6)
fast: false
kinetic law: 812119
reversible: false
reactant: 812047
reactant: 812011
product: 812095
reactant: 811999

812035
type: SpeciesReference
stoichiometry: 4.0
species: 768335

812071
type: SpeciesReference
stoichiometry: 1.0
species: 766616

812107
type: SpeciesReference
stoichiometry: 1.0
species: 768666

812059
type: SpeciesReference
stoichiometry: 1.0
species: 766604

812083
type: SpeciesReference
stoichiometry: 3.0
species: 767779

812023
type: SpeciesReference
stoichiometry: 1.0
species: 768154

812167
type: LocalParameter
value: 500.0

812155
type: LocalParameter
value: 0.0

812143
type: LocalParameter
value: 1000.0

812131
type: LocalParameter
value: 0.0

812047
type: SpeciesReference
stoichiometry: 1.0
species: 768359

812011
type: SpeciesReference
stoichiometry: 5.0
species: 767767

812095
type: SpeciesReference
stoichiometry: 4.0
species: 768323

811999
type: SpeciesReference
stoichiometry: 1.0
species: 767355

806521
type: Reaction
kinetic law: 806557
product: 806545
reactant: 806533
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: eicosenoate (C20:1, n-11) transport

806605
type: LocalParameter
value: 0.0

806593
type: LocalParameter
value: 0.0

806581
type: LocalParameter
value: 1000.0

806569
type: LocalParameter
value: -1000.0

806545
type: SpeciesReference
stoichiometry: 1.0
species: 765273

806533
type: SpeciesReference
stoichiometry: 1.0
species: 767164

806413
type: Reaction
kinetic law: 806461
product: 806449
reactant: 806437
reactant: 806425
notes: GENE_ASSOCIATION: ((NM_000182.3 and NM_000183.1) or NM_004092.2) GENE_LIST: NM_000182.3 NM_000183.1 NM_004092.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
fast: false
reversible: true
name: enoyl-CoA hydratase, mitochondrial

806509
type: LocalParameter
value: 0.0

806497
type: LocalParameter
value: 0.0

806485
type: LocalParameter
value: 1000.0

806473
type: LocalParameter
value: -1000.0

806449
type: SpeciesReference
stoichiometry: 1.0
species: 769525

769525
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: (S)-3-Hydroxy-2-methylbutyryl-CoA

806437
type: SpeciesReference
stoichiometry: 1.0
species: 770345

806425
type: SpeciesReference
stoichiometry: 1.0
species: 769476

851251
type: Reaction
kinetic law: 851299
product: 851287
product: 851275
reactant: 851263
notes: GENE_ASSOCIATION: NM_006843.2 GENE_LIST: NM_006843.2 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
fast: false
reversible: false
name: L-serine deaminase

851347
type: LocalParameter
value: 500.0

851335
type: LocalParameter
value: 0.0

851323
type: LocalParameter
value: 1000.0

851311
type: LocalParameter
value: 0.0

851287
type: SpeciesReference
stoichiometry: 1.0
species: 768981

851275
type: SpeciesReference
stoichiometry: 1.0
species: 768347

851263
type: SpeciesReference
stoichiometry: 1.0
species: 769041

766518
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Choline

782449
type: Reaction
reactant: 782691
reactant: 782715
product: 782763
reactant: 782582
reactant: 782667
reactant: 782727
fast: false
kinetic law: 782787
reactant: 782679
reactant: 782703
reactant: 782534
reactant: 782655
reactant: 782606
reactant: 782546
product: 782775
reactant: 782739
reactant: 782618
reactant: 782642
reactant: 782461
reactant: 782474
reactant: 782486
reactant: 782510
reactant: 782594
notes: GENE_ASSOCIATION: (NM_006411.2 or NM_001037553.1 or NM_020132.4 or NM_001002257.1 or NM_020133.2 or NM_032741.3 or NM_001012727.1 or NM_006412.3 or NM_018361.3 or NM_153613.2 or NM_178819.2 or NM_182551.3) GENE_LIST: NM_001002257.1 NM_001012727.1 NM_001037553.1 NM_006411.2 NM_006412.3 NM_018361.3 NM_020132.4 NM_020133.2 NM_032741.3 NM_153613.2 NM_178819.2 NM_182551.3 SUBSYSTEM: Phospholipid Metabolism
name: 1-Acyl-glycerol-3-phosphate acyltransferase, adipocyte specific
reversible: false
reactant: 782751
reactant: 782498
reactant: 782558
reactant: 782630
reactant: 782522
reactant: 782570

782691
type: SpeciesReference
stoichiometry: 0.002
species: 768666

782715
type: SpeciesReference
stoichiometry: 0.243
species: 768825

782763
type: SpeciesReference
stoichiometry: 1.0
species: 766616

782582
type: SpeciesReference
stoichiometry: 0.004
species: 767355

782667
type: SpeciesReference
stoichiometry: 0.018
species: 768569

782727
type: SpeciesReference
stoichiometry: 0.064
species: 769101

782835
type: LocalParameter
value: 500.0

782823
type: LocalParameter
value: 0.0

782811
type: LocalParameter
value: 1000.0

782799
type: LocalParameter
value: 0.0

782679
type: SpeciesReference
stoichiometry: 0.393
species: 768581

782703
type: SpeciesReference
stoichiometry: 0.003
species: 768739

782534
type: SpeciesReference
stoichiometry: 0.003
species: 767215

782655
type: SpeciesReference
stoichiometry: 0.003
species: 768556

782606
type: SpeciesReference
stoichiometry: 0.005
species: 767876

782546
type: SpeciesReference
stoichiometry: 0.002
species: 767241

782775
type: SpeciesReference
stoichiometry: 0.001
species: 768690

782739
type: SpeciesReference
stoichiometry: 0.037
species: 769137

782618
type: SpeciesReference
stoichiometry: 0.003
species: 767997

782642
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species: 768520

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species: 765888

765888
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 1-Acyl-sn-glycerol 3-phosphate, adipocyte

782474
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species: 766846

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species: 769161

769161
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has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: tetradecenoyl-CoA (C14:1CoA, n-5)

782498
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species: 766992

782558
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species: 767254

782630
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species: 768470

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species: 767306

765261
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765093
name: Eicosanoate (n-C20:0)

799754
type: Reaction
product: 799814
name: CTP synthase (NH3)
product: 799826
reactant: 799790
reactant: 799778
reactant: 799766
product: 799802
product: 799838
reversible: false
kinetic law: 799850
notes: GENE_ASSOCIATION: NM_001905.1 GENE_LIST: NM_001905.1 SUBSYSTEM: Nucleotide Metabolism
fast: false

799814
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species: 766640

799826
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species: 767767

799790
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species: 769379

799778
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species: 768347

799766
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species: 766398

799802
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species: 766240

799838
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stoichiometry: 1.0
species: 768800

799898
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value: 500.0

799886
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value: 0.0

799874
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value: 1000.0

799862
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value: 0.0

807015
type: Reaction
kinetic law: 807064
product: 807051
product: 807039
reactant: 807027
notes: GENE_ASSOCIATION: (NM_001975.2 or NM_001976.2 or NM_053013.1 or NM_001428.2) GENE_LIST: NM_001428.2 NM_001975.2 NM_001976.2 NM_053013.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: enolase

807113
type: LocalParameter
value: 0.0

807101
type: LocalParameter
value: 0.0

807088
type: LocalParameter
value: 1000.0

807076
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value: -1000.0

807051
type: SpeciesReference
stoichiometry: 1.0
species: 768776

807039
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stoichiometry: 1.0
species: 767779

807027
type: SpeciesReference
stoichiometry: 1.0
species: 765938

839700
type: Reaction
product: 839748
notes: GENE_ASSOCIATION: ((NM_001018137.1 and NM_198175.1) or (NM_000269.2 and NM_001018137.1) or NM_002513.2 or NM_005793.3 or (NM_000269.2 and NM_001018138.1) or (NM_000269.2 and NM_002512.2) or (NM_002512.2 and NM_198175.1) or (NM_000269.2 and NM_001018139.1) or (NM_001018138.1 and NM_198175.1) or (NM_001018139.1 and NM_198175.1) or NM_013330.3 or NM_197972.1) GENE_LIST: NM_000269.2 NM_001018137.1 NM_001018138.1 NM_001018139.1 NM_002512.2 NM_002513.2 NM_005793.3 NM_013330.3 NM_197972.1 NM_198175.1 SUBSYSTEM: Nucleotide Metabolism
product: 839736
name: nucleoside-diphosphate kinase (ATP:GDP)
reactant: 839712
kinetic law: 839761
reactant: 839724
reversible: true
fast: false

839748
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stoichiometry: 1.0
species: 767755

839736
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stoichiometry: 1.0
species: 766240

839712
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stoichiometry: 1.0
species: 766398

839809
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value: 0.0

839797
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value: 0.0

839785
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value: 1000.0

839773
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value: -1000.0

839724
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stoichiometry: 1.0
species: 767597

770465
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Hexanoyl-CoA (C6:0CoA)

818067
type: Reaction
reactant: 818128
reversible: false
product: 818164
product: 818176
product: 818140
reactant: 818103
name: Beta oxidation of fatty acid
kinetic law: 818200
fast: false
product: 818152
reactant: 818116
product: 818188
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_004493.2) or (NM_001608.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_005327.2) or (NM_001127328.1 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001608.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000016.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001127328.1 and NM_004092.2 and NM_001037811.2) or (NM_000016.2 and (NM_000182.3 and NM_000183.1))) GENE_LIST: NM_000016.2 NM_000182.3 NM_000183.1 NM_001037811.2 NM_001127328.1 NM_001608.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 SUBSYSTEM: Fatty acid oxidation
reactant: 818091
reactant: 818079

818128
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stoichiometry: 1.0
species: 770732

770732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: Octanoyl-CoA (C8:0CoA)

818164
type: SpeciesReference
stoichiometry: 1.0
species: 770333

818176
type: SpeciesReference
stoichiometry: 1.0
species: 770465

818140
type: SpeciesReference
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species: 769657

818103
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species: 770345

818249
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value: 500.0

818237
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value: 0.0

818224
type: LocalParameter
value: 1000.0

818212
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value: 0.0

818152
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stoichiometry: 1.0
species: 770165

818116
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stoichiometry: 1.0
species: 770622

818188
type: SpeciesReference
stoichiometry: 1.0
species: 770634

818091
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stoichiometry: 1.0
species: 770153

818079
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stoichiometry: 1.0
species: 769851

767707
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: GMP

803080
type: Reaction
product: 803153
reactant: 803104
reversible: false
reactant: 803116
name: stearoyl-CoA desaturase (n-C18:0CoA -> C18:1CoA, n-5)
product: 803166
reactant: 803129
fast: false
reactant: 803092
notes: SUBSYSTEM: Fatty Acid Desaturation
kinetic law: 803178
product: 803141

803153
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stoichiometry: 1.0
species: 768323

803104
type: SpeciesReference
stoichiometry: 1.0
species: 768335

803116
type: SpeciesReference
stoichiometry: 1.0
species: 768359

803166
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stoichiometry: 1.0
species: 768556

803129
type: SpeciesReference
stoichiometry: 1.0
species: 769101

803092
type: SpeciesReference
stoichiometry: 1.0
species: 767767

803227
type: LocalParameter
value: 500.0

803215
type: LocalParameter
value: 0.0

803202
type: LocalParameter
value: 1000.0

803190
type: LocalParameter
value: 0.0

803141
type: SpeciesReference
stoichiometry: 2.0
species: 767779

825135
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (NM_004169.3 or NM_148918.1) GENE_LIST: NM_004169.3 NM_148918.1 SUBSYSTEM: Serine metabolism
reversible: true
product: 825183
reactant: 825159
product: 825195
name: glycine hydroxymethyltransferase
product: 825171
reactant: 825147
kinetic law: 825207

825183
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species: 767779

825159
type: SpeciesReference
stoichiometry: 1.0
species: 769198

825195
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species: 768238

825171
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stoichiometry: 1.0
species: 767658

825147
type: SpeciesReference
stoichiometry: 1.0
species: 769041

825255
type: LocalParameter
value: 0.0

825243
type: LocalParameter
value: 0.0

825231
type: LocalParameter
value: 1000.0

825219
type: LocalParameter
value: -1000.0

823699
type: Reaction
reversible: false
reactant: 823711
name: glucose-6-phosphatase
notes: SUBSYSTEM: Pentose Phosphate Pathway
product: 823747
reactant: 823723
fast: false
kinetic law: 823759
product: 823735

823711
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species: 771420

823747
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stoichiometry: 1.0
species: 771552

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species: 771456

823807
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value: 500.0

823795
type: LocalParameter
value: 0.0

823783
type: LocalParameter
value: 1000.0

823771
type: LocalParameter
value: 0.0

823735
type: SpeciesReference
stoichiometry: 1.0
species: 771432

778976
type: Reaction
kinetic law: 779015
product: 779002
reactant: 778989
fast: false
reversible: true
name: L-Valine exchange

779063
type: LocalParameter
value: -1.03694E-4

779051
type: LocalParameter
value: 0.0

779039
type: LocalParameter
value: 0.0

779027
type: LocalParameter
value: -2.07387999999999E-4

779002
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stoichiometry: 1.0
species: 772552

772552
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765105
name: val_L_b

778989
type: SpeciesReference
stoichiometry: 1.0
species: 765840

840788
type: Reaction
kinetic law: 840825
product: 840812
reactant: 840800
notes: GENE_ASSOCIATION: (NM_016321.1 or NM_020407.1 or NM_000324.1) GENE_LIST: NM_000324.1 NM_016321.1 NM_020407.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: ammonium transport via diffusion

840873
type: LocalParameter
value: 0.0

840861
type: LocalParameter
value: 0.0

840849
type: LocalParameter
value: 1000.0

840837
type: LocalParameter
value: -1000.0

840812
type: SpeciesReference
stoichiometry: 1.0
species: 768347

840800
type: SpeciesReference
stoichiometry: 1.0
species: 765587

787876
type: Reaction
kinetic law: 787924
product: 787912
product: 787900
reactant: 787888
notes: SUBSYSTEM: Other
fast: false
reversible: false
name: catalase

787972
type: LocalParameter
value: 500.0

787960
type: LocalParameter
value: 0.0

787948
type: LocalParameter
value: 1000.0

787936
type: LocalParameter
value: 0.0

787912
type: SpeciesReference
stoichiometry: 1.0
species: 768359

787900
type: SpeciesReference
stoichiometry: 2.0
species: 767779

787888
type: SpeciesReference
stoichiometry: 2.0
species: 767791

830299
type: Reaction
kinetic law: 830335
product: 830323
reactant: 830311
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecenoate (C16:1, n-7) transport

830383
type: LocalParameter
value: 0.0

830371
type: LocalParameter
value: 0.0

830359
type: LocalParameter
value: 1000.0

830347
type: LocalParameter
value: -1000.0

830323
type: SpeciesReference
stoichiometry: 1.0
species: 765454

830311
type: SpeciesReference
stoichiometry: 1.0
species: 767839

799911
type: Reaction
notes: GENE_ASSOCIATION: (NM_019857.3 or NM_175859.1) GENE_LIST: NM_019857.3 NM_175859.1 SUBSYSTEM: Pyrimidine Biosynthesis
reversible: false
reactant: 799959
reactant: 799947
product: 799995
product: 799983
product: 799971
reactant: 799923
fast: false
kinetic law: 800031
product: 800019
reactant: 799935
product: 800007
name: CTP synthase (glutamine)

799959
type: SpeciesReference
stoichiometry: 1.0
species: 769379

799947
type: SpeciesReference
stoichiometry: 1.0
species: 767779

799995
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species: 767633

799983
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stoichiometry: 1.0
species: 766640

799971
type: SpeciesReference
stoichiometry: 1.0
species: 766240

799923
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stoichiometry: 1.0
species: 766398

800080
type: LocalParameter
value: 500.0

800068
type: LocalParameter
value: 0.0

800056
type: LocalParameter
value: 1000.0

800044
type: LocalParameter
value: 0.0

800019
type: SpeciesReference
stoichiometry: 1.0
species: 768800

799935
type: SpeciesReference
stoichiometry: 1.0
species: 767621

800007
type: SpeciesReference
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species: 767767

802071
type: Reaction
kinetic law: 802107
product: 802095
reactant: 802083
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: docosenoate (C22:1, n-9) transport

802155
type: LocalParameter
value: 0.0

802143
type: LocalParameter
value: 0.0

802131
type: LocalParameter
value: 1000.0

802119
type: LocalParameter
value: -1000.0

802095
type: SpeciesReference
stoichiometry: 1.0
species: 765213

802083
type: SpeciesReference
stoichiometry: 1.0
species: 766784

811793
type: Reaction
reversible: false
reactant: 811841
product: 811877
product: 811902
notes: SUBSYSTEM: Fatty Acid Synthesis
reactant: 811817
fast: false
reactant: 811805
product: 811865
reactant: 811829
product: 811889
product: 811914
kinetic law: 811927
reactant: 811853
name: fatty-acyl-CoA elongation (C20:4CoA, n3)

811841
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stoichiometry: 1.0
species: 768359

811877
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stoichiometry: 1.0
species: 766616

811902
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species: 767779

811817
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species: 768154

811805
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stoichiometry: 5.0
species: 767767

811865
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stoichiometry: 1.0
species: 766604

811829
type: SpeciesReference
stoichiometry: 4.0
species: 768335

811889
type: SpeciesReference
stoichiometry: 1.0
species: 767343

767343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: eicosatetraenoyl-CoA (C20:4CoA, n-3)

811914
type: SpeciesReference
stoichiometry: 4.0
species: 768323

811975
type: LocalParameter
value: 500.0

811963
type: LocalParameter
value: 0.0

811951
type: LocalParameter
value: 1000.0

811939
type: LocalParameter
value: 0.0

811853
type: SpeciesReference
stoichiometry: 1.0
species: 769125

829958
type: Reaction
name: HCO3 equilibration reaction, mitochondrial
kinetic law: 830019
reactant: 829970
fast: false
reversible: true
reactant: 829982
product: 830006
notes: GENE_ASSOCIATION: (NM_001739.1 or NM_007220.2) GENE_LIST: NM_001739.1 NM_007220.2 SUBSYSTEM: Central Metabolism
product: 829994

830068
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value: 0.0

830056
type: LocalParameter
value: 0.0

830044
type: LocalParameter
value: 1000.0

830032
type: LocalParameter
value: -1000.0

829970
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stoichiometry: 1.0
species: 769839

829982
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species: 770345

830006
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species: 770369

829994
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species: 770333

804946
type: Reaction
product: 805006
reactant: 804970
name: 7-dehydrocholesterol reductase
reactant: 804958
fast: false
product: 804994
reversible: false
notes: GENE_ASSOCIATION: NM_001360.1 GENE_LIST: NM_001360.1 SUBSYSTEM: Cholesterol Metabolism
reactant: 804982
kinetic law: 805018

805006
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stoichiometry: 1.0
species: 771516

804970
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stoichiometry: 1.0
species: 771444

804958
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species: 771312

804994
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stoichiometry: 1.0
species: 771348

771348
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Cholesterol

804982
type: SpeciesReference
stoichiometry: 1.0
species: 771528

805066
type: LocalParameter
value: 500.0

805054
type: LocalParameter
value: 0.0

805042
type: LocalParameter
value: 1000.0

805030
type: LocalParameter
value: 0.0

823314
type: Reaction
notes: SUBSYSTEM: Proline Metabolism
name: L-glutamate 5-semialdehyde dehydratase (spontaneous)
product: 823362
fast: false
reactant: 823326
product: 823338
reversible: true
product: 823350
kinetic law: 823374

823362
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stoichiometry: 1.0
species: 767779

823326
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stoichiometry: 1.0
species: 767645

823338
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stoichiometry: 1.0
species: 765901

823350
type: SpeciesReference
stoichiometry: 1.0
species: 767767

823422
type: LocalParameter
value: 0.0

823410
type: LocalParameter
value: 0.0

823398
type: LocalParameter
value: 1000.0

823386
type: LocalParameter
value: -1000.0

844679
type: Reaction
reactant: 844691
product: 844727
name: phosphoglycerate dehydrogenase
kinetic law: 844751
reversible: true
notes: GENE_ASSOCIATION: NM_006623.2 GENE_LIST: NM_006623.2 SUBSYSTEM: Amino Acid Metabolism
product: 844739
product: 844715
fast: false
reactant: 844703

844691
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stoichiometry: 1.0
species: 765974

844727
type: SpeciesReference
stoichiometry: 1.0
species: 767767

844799
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value: 0.0

844787
type: LocalParameter
value: 0.0

844775
type: LocalParameter
value: 1000.0

844763
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value: -1000.0

844739
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stoichiometry: 1.0
species: 768310

844715
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stoichiometry: 1.0
species: 765986

765986
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 3-Phosphohydroxypyruvate

844703
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stoichiometry: 1.0
species: 768298

843872
type: Reaction
fast: false
kinetic law: 843969
reactant: 843909
name: pyruvate carboxylase, mitochondrial
product: 843945
notes: GENE_ASSOCIATION: (NM_022172.1 or NM_000920.2 or NM_001040716.1) GENE_LIST: NM_000920.2 NM_001040716.1 NM_022172.1 SUBSYSTEM: Pyruvate Metabolism
reversible: false
product: 843921
product: 843957
reactant: 843897
product: 843933
reactant: 843884

844017
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value: 500.0

844005
type: LocalParameter
value: 0.0

843993
type: LocalParameter
value: 1000.0

843981
type: LocalParameter
value: 0.0

843909
type: SpeciesReference
stoichiometry: 1.0
species: 771070

843945
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stoichiometry: 1.0
species: 770719

843921
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stoichiometry: 1.0
species: 769681

843957
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stoichiometry: 1.0
species: 770985

843897
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species: 770369

843933
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stoichiometry: 1.0
species: 770333

843884
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stoichiometry: 1.0
species: 769730

805587
type: Reaction
reversible: false
product: 805636
reactant: 805612
name: dimethylallyltranstransferase
kinetic law: 805648
reactant: 805599
fast: false
notes: GENE_ASSOCIATION: NM_002004.2 GENE_LIST: NM_002004.2 SUBSYSTEM: Cholesterol Biosynthesis
product: 805624

805636
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stoichiometry: 1.0
species: 768885

805612
type: SpeciesReference
stoichiometry: 1.0
species: 768082

805696
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value: 500.0

805684
type: LocalParameter
value: 0.0

805672
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value: 1000.0

805660
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value: 0.0

805599
type: SpeciesReference
stoichiometry: 1.0
species: 766944

805624
type: SpeciesReference
stoichiometry: 1.0
species: 767719

843495
type: Reaction
notes: GENE_ASSOCIATION: (NM_013328.2 or NM_023078.1) GENE_LIST: NM_013328.2 NM_023078.1 SUBSYSTEM: Amino Acid Metabolism
product: 843544
reactant: 843532
fast: false
product: 843557
name: pyrroline-5-carboxylate reductase
reversible: false
kinetic law: 843569
reactant: 843507
reactant: 843519

843544
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stoichiometry: 1.0
species: 768323

843532
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stoichiometry: 1.0
species: 768335

843557
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stoichiometry: 1.0
species: 768921

843617
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value: 500.0

843605
type: LocalParameter
value: 0.0

843593
type: LocalParameter
value: 1000.0

843581
type: LocalParameter
value: 0.0

843507
type: SpeciesReference
stoichiometry: 1.0
species: 765901

843519
type: SpeciesReference
stoichiometry: 2.0
species: 767767

770417
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: hexadecenoyl carnitine (C16:1Crn, n-9)

851155
type: Reaction
kinetic law: 851191
product: 851179
reactant: 851167
notes: SUBSYSTEM: Glycine and Serine Metabolism
fast: false
reversible: true
name: Sarcosine transport (peroxisomal)

851239
type: LocalParameter
value: 0.0

851227
type: LocalParameter
value: 0.0

851215
type: LocalParameter
value: 1000.0

851203
type: LocalParameter
value: -1000.0

851179
type: SpeciesReference
stoichiometry: 1.0
species: 771816

771816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765081
name: Sarcosine

851167
type: SpeciesReference
stoichiometry: 1.0
species: 769029

769029
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Sarcosine

784107
type: Reaction
notes: GENE_ASSOCIATION: NM_000696.2 GENE_LIST: NM_000696.2 SUBSYSTEM: Cholesterol Metabolism
reversible: false
reactant: 784144
name: aldehyde dehydrogenase (acetaldehyde, NAD)
fast: false
reactant: 784132
product: 784180
product: 784156
reactant: 784120
kinetic law: 784192
product: 784168

784144
type: SpeciesReference
stoichiometry: 1.0
species: 768298

784132
type: SpeciesReference
stoichiometry: 1.0
species: 767779

784180
type: SpeciesReference
stoichiometry: 1.0
species: 768310

784156
type: SpeciesReference
stoichiometry: 1.0
species: 766168

784120
type: SpeciesReference
stoichiometry: 1.0
species: 766192

784240
type: LocalParameter
value: 500.0

784228
type: LocalParameter
value: 0.0

784216
type: LocalParameter
value: 1000.0

784204
type: LocalParameter
value: 0.0

784168
type: SpeciesReference
stoichiometry: 2.0
species: 767767

795116
type: Reaction
product: 795168
reversible: true
reactant: 795142
kinetic law: 795181
name: octadecenoyl carnitine transport (C18:1Crn, n5)
product: 795155
notes: GENE_ASSOCIATION: (NM_000387.3 or NM_001039355.1) GENE_LIST: NM_000387.3 NM_001039355.1 SUBSYSTEM: Carnitine Shuttle
reactant: 795129
fast: false

795168
type: SpeciesReference
stoichiometry: 1.0
species: 770829

795142
type: SpeciesReference
stoichiometry: 1.0
species: 769863

795231
type: LocalParameter
value: 0.0

795219
type: LocalParameter
value: 0.0

795207
type: LocalParameter
value: 1000.0

795194
type: LocalParameter
value: -1000.0

795155
type: SpeciesReference
stoichiometry: 1.0
species: 766628

795129
type: SpeciesReference
stoichiometry: 1.0
species: 768593

768593
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: octadecenoyl carnitine (C18:1Crn, n5)

779208
type: Reaction
kinetic law: 779244
product: 779232
reactant: 779220
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: 6-Phospho-D-gluconate transport in/out via proton symport

779292
type: LocalParameter
value: 0.0

779280
type: LocalParameter
value: 0.0

779268
type: LocalParameter
value: 1000.0

779256
type: LocalParameter
value: -1000.0

779232
type: SpeciesReference
stoichiometry: 1.0
species: 771288

771288
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 6-Phospho-D-gluconate

779220
type: SpeciesReference
stoichiometry: 1.0
species: 766095

834362
type: Reaction
product: 834458
name: cytochrome P450 lanosterol 14-alpha-demethylase
reactant: 834410
reactant: 834374
product: 834434
product: 834446
kinetic law: 834470
notes: GENE_ASSOCIATION: NM_000786.2 GENE_LIST: NM_000786.2 SUBSYSTEM: Cholesterol Biosynthesis
reactant: 834398
fast: false
reversible: false
reactant: 834386
product: 834422

834458
type: SpeciesReference
stoichiometry: 3.0
species: 771516

834410
type: SpeciesReference
stoichiometry: 3.0
species: 771540

834374
type: SpeciesReference
stoichiometry: 2.0
species: 771444

834434
type: SpeciesReference
stoichiometry: 1.0
species: 771396

834446
type: SpeciesReference
stoichiometry: 4.0
species: 771456

834518
type: LocalParameter
value: 500.0

834506
type: LocalParameter
value: 0.0

834494
type: LocalParameter
value: 1000.0

834482
type: LocalParameter
value: 0.0

834398
type: SpeciesReference
stoichiometry: 3.0
species: 771528

834386
type: SpeciesReference
stoichiometry: 1.0
species: 771468

771468
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: Lanosterol

834422
type: SpeciesReference
stoichiometry: 1.0
species: 771240

833035
type: Reaction
kinetic law: 833084
product: 833072
reactant: 833059
reactant: 833047
notes: GENE_ASSOCIATION: NM_004044.4 GENE_LIST: NM_004044.4 SUBSYSTEM: Nucleotide Metabolism
fast: false
reversible: true
name: IMP cyclohydrolase

833132
type: LocalParameter
value: 0.0

833120
type: LocalParameter
value: 0.0

833108
type: LocalParameter
value: 1000.0

833096
type: LocalParameter
value: -1000.0

833072
type: SpeciesReference
stoichiometry: 1.0
species: 767512

833059
type: SpeciesReference
stoichiometry: 1.0
species: 768058

833047
type: SpeciesReference
stoichiometry: 1.0
species: 767779

811406
type: Reaction
product: 811502
reactant: 811430
fast: false
product: 811478
reactant: 811442
reactant: 811454
product: 811490
product: 811514
product: 811527
notes: GENE_ASSOCIATION: NM_021814.3 GENE_LIST: NM_021814.3 SUBSYSTEM: Fatty acid elongation
kinetic law: 811540
reactant: 811418
name: fatty-acyl-CoA elongation (n-C20:2CoA, n6)
reversible: false
reactant: 811466

811502
type: SpeciesReference
stoichiometry: 1.0
species: 767215

811430
type: SpeciesReference
stoichiometry: 1.0
species: 768154

811478
type: SpeciesReference
stoichiometry: 1.0
species: 766604

811442
type: SpeciesReference
stoichiometry: 4.0
species: 768335

811454
type: SpeciesReference
stoichiometry: 1.0
species: 768359

811490
type: SpeciesReference
stoichiometry: 1.0
species: 766616

811514
type: SpeciesReference
stoichiometry: 3.0
species: 767779

811527
type: SpeciesReference
stoichiometry: 4.0
species: 768323

811588
type: LocalParameter
value: 500.0

811576
type: LocalParameter
value: 0.0

811564
type: LocalParameter
value: 1000.0

811552
type: LocalParameter
value: 0.0

811418
type: SpeciesReference
stoichiometry: 5.0
species: 767767

811466
type: SpeciesReference
stoichiometry: 1.0
species: 768470

806082
type: Reaction
kinetic law: 806143
reactant: 806094
fast: false
notes: GENE_ASSOCIATION: NM_012145.2 GENE_LIST: NM_012145.2 SUBSYSTEM: Nucleotide Metabolism
name: dTMP kinase
product: 806131
reversible: true
reactant: 806107
product: 806119

806191
type: LocalParameter
value: 0.0

806179
type: LocalParameter
value: 0.0

806167
type: LocalParameter
value: 1000.0

806155
type: LocalParameter
value: -1000.0

806094
type: SpeciesReference
stoichiometry: 1.0
species: 766398

806131
type: SpeciesReference
stoichiometry: 1.0
species: 767040

767040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: dTDP

806107
type: SpeciesReference
stoichiometry: 1.0
species: 767052

806119
type: SpeciesReference
stoichiometry: 1.0
species: 766240

850284
type: Reaction
fast: false
notes: GENE_ASSOCIATION: ((NM_001033.2 and NM_001034.1) and NM_003329.2) GENE_LIST: NM_001033.2 NM_001034.1 NM_003329.2 SUBSYSTEM: Nucleotide Metabolism
product: 850332
reversible: false
product: 850345
name: ribonucleoside-diphosphate reductase (ADP)
product: 850320
kinetic law: 850357
reactant: 850308
reactant: 850296

850332
type: SpeciesReference
stoichiometry: 1.0
species: 767779

850345
type: SpeciesReference
stoichiometry: 1.0
species: 769234

850320
type: SpeciesReference
stoichiometry: 1.0
species: 766676

850405
type: LocalParameter
value: 500.0

850393
type: LocalParameter
value: 0.0

850381
type: LocalParameter
value: 1000.0

850369
type: LocalParameter
value: 0.0

850308
type: SpeciesReference
stoichiometry: 1.0
species: 769246

850296
type: SpeciesReference
stoichiometry: 1.0
species: 766240

769355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: UMP

816040
type: Reaction
fast: false
reactant: 816064
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_001033859.1 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.... NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
kinetic law: 816161
product: 816137
product: 816124
product: 816112
reactant: 816088
reactant: 816076
product: 816149
reversible: false
reactant: 816100
reactant: 816052
name: Beta oxidation of fatty acid

816064
type: SpeciesReference
stoichiometry: 1.0
species: 770032

816211
type: LocalParameter
value: 500.0

816198
type: LocalParameter
value: 0.0

816185
type: LocalParameter
value: 1000.0

816173
type: LocalParameter
value: 0.0

816137
type: SpeciesReference
stoichiometry: 9.0
species: 770333

816124
type: SpeciesReference
stoichiometry: 7.0
species: 770165

816112
type: SpeciesReference
stoichiometry: 10.0
species: 769657

816088
type: SpeciesReference
stoichiometry: 9.0
species: 770345

816076
type: SpeciesReference
stoichiometry: 7.0
species: 770153

816149
type: SpeciesReference
stoichiometry: 9.0
species: 770634

816100
type: SpeciesReference
stoichiometry: 9.0
species: 770622

816052
type: SpeciesReference
stoichiometry: 9.0
species: 769851

825788
type: Reaction
name: glutamine synthetase
product: 825861
reactant: 825825
fast: false
reactant: 825801
reversible: false
notes: GENE_ASSOCIATION: (NM_001033056.1 or NM_002065.4 or NM_001033044.1) GENE_LIST: NM_001033044.1 NM_001033056.1 NM_002065.4 SUBSYSTEM: Glutamine Metabolism
product: 825837
reactant: 825813
product: 825849
product: 825873
kinetic law: 825885

825861
type: SpeciesReference
stoichiometry: 1.0
species: 767767

825825
type: SpeciesReference
stoichiometry: 1.0
species: 768347

825801
type: SpeciesReference
stoichiometry: 1.0
species: 766398

825837
type: SpeciesReference
stoichiometry: 1.0
species: 766240

825813
type: SpeciesReference
stoichiometry: 1.0
species: 767633

825849
type: SpeciesReference
stoichiometry: 1.0
species: 767621

825873
type: SpeciesReference
stoichiometry: 1.0
species: 768800

825933
type: LocalParameter
value: 500.0

825921
type: LocalParameter
value: 0.0

825909
type: LocalParameter
value: 1000.0

825897
type: LocalParameter
value: 0.0

816223
type: Reaction
reactant: 816235
product: 816331
product: 816307
reversible: false
reactant: 816247
reactant: 816271
kinetic law: 816343
reactant: 816259
reactant: 816283
fast: false
product: 816319
name: Beta oxidation of fatty acid
product: 816295
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_000018.2 and NM_001359.1 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or... GENE_LIST: NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 or... SUBSYSTEM: Fatty acid oxidation

816235
type: SpeciesReference
stoichiometry: 9.0
species: 769851

816331
type: SpeciesReference
stoichiometry: 9.0
species: 770634

816307
type: SpeciesReference
stoichiometry: 6.0
species: 770165

816247
type: SpeciesReference
stoichiometry: 1.0
species: 770105

816271
type: SpeciesReference
stoichiometry: 9.0
species: 770345

816391
type: LocalParameter
value: 500.0

816379
type: LocalParameter
value: 0.0

816367
type: LocalParameter
value: 1000.0

816355
type: LocalParameter
value: 0.0

816259
type: SpeciesReference
stoichiometry: 6.0
species: 770153

816283
type: SpeciesReference
stoichiometry: 9.0
species: 770622

816319
type: SpeciesReference
stoichiometry: 9.0
species: 770333

816295
type: SpeciesReference
stoichiometry: 10.0
species: 769657

780887
type: Reaction
kinetic law: 780923
product: 780911
reactant: 780899
notes: GENE_ASSOCIATION: NM_001098.2 GENE_LIST: NM_001098.2 SUBSYSTEM: Citrate Cycle (TCA)
fast: false
reversible: true
name: Aconitate hydratase

780971
type: LocalParameter
value: 0.0

780959
type: LocalParameter
value: 0.0

780947
type: LocalParameter
value: 1000.0

780935
type: LocalParameter
value: -1000.0

780911
type: SpeciesReference
stoichiometry: 1.0
species: 770489

780899
type: SpeciesReference
stoichiometry: 1.0
species: 769790

837804
type: Reaction
reactant: 837840
notes: SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 837864
reactant: 837828
reversible: false
name: (S)-methylmalonyl-CoA hydrolase
reactant: 837816
product: 837852
fast: false
kinetic law: 837876

837840
type: SpeciesReference
stoichiometry: 1.0
species: 770574

837864
type: SpeciesReference
stoichiometry: 1.0
species: 770610

837828
type: SpeciesReference
stoichiometry: 1.0
species: 770333

837816
type: SpeciesReference
stoichiometry: 1.0
species: 769851

837852
type: SpeciesReference
stoichiometry: 1.0
species: 770345

837925
type: LocalParameter
value: 500.0

837913
type: LocalParameter
value: 0.0

837901
type: LocalParameter
value: 1000.0

837888
type: LocalParameter
value: 0.0

827610
type: Reaction
kinetic law: 827671
product: 827659
fast: false
product: 827646
notes: GENE_ASSOCIATION: ((NM_004130.2 and NM_002103.3) or (NM_004130.2 and NM_021957.2) or (NM_001079855.1 and NM_002103.3) or (NM_003918.1 and NM_002103.3) or (NM_001079855.1 and NM_021957.2) or (NM_003918.1 and NM_021957.2)) GENE_LIST: NM_001079855.1 NM_002103.3 NM_003918.1 NM_004130.2 NM_021957.2 SUBSYSTEM: Glycogen Metabolism
name: glycogen synthase (UDPGlc)
product: 827634
reversible: false
reactant: 827622

827719
type: LocalParameter
value: 500.0

827707
type: LocalParameter
value: 0.0

827695
type: LocalParameter
value: 1000.0

827683
type: LocalParameter
value: 0.0

827659
type: SpeciesReference
stoichiometry: 1.0
species: 769330

827646
type: SpeciesReference
stoichiometry: 1.0
species: 767767

827634
type: SpeciesReference
stoichiometry: 1.0
species: 767695

827622
type: SpeciesReference
stoichiometry: 1.0
species: 769343

798035
type: Reaction
fast: false
product: 798083
kinetic law: 798095
reversible: true
name: carnitine O-palmitoyltransferase (C16:0Crn)
notes: GENE_ASSOCIATION: (NM_152245.1 or NM_001031847.1 or NM_152359.1 or NM_152246.1 or NM_004377.2 or NM_001876.2 or NM_152247.1) GENE_LIST: NM_001031847.1 NM_001876.2 NM_004377.2 NM_152245.1 NM_152246.1 NM_152247.1 NM_152359.1 SUBSYSTEM: Carnitine Shuttle
product: 798071
reactant: 798059
reactant: 798047

798083
type: SpeciesReference
stoichiometry: 1.0
species: 768837

798143
type: LocalParameter
value: 0.0

798131
type: LocalParameter
value: 0.0

798119
type: LocalParameter
value: 1000.0

798107
type: LocalParameter
value: -1000.0

798071
type: SpeciesReference
stoichiometry: 1.0
species: 766616

798059
type: SpeciesReference
stoichiometry: 1.0
species: 768825

798047
type: SpeciesReference
stoichiometry: 1.0
species: 766628

788202
type: Reaction
reactant: 788238
fast: false
product: 788298
product: 788310
reactant: 788214
kinetic law: 788322
notes: GENE_ASSOCIATION: NM_004341.3 GENE_LIST: NM_004341.3 SUBSYSTEM: Nucleotide Metabolism
product: 788286
reactant: 788226
reversible: false
product: 788274
reactant: 788250
name: carbamoyl-phosphate synthase (glutamine-hydrolysing)
product: 788262

788238
type: SpeciesReference
stoichiometry: 1.0
species: 767779

788298
type: SpeciesReference
stoichiometry: 2.0
species: 767767

788310
type: SpeciesReference
stoichiometry: 1.0
species: 768800

788214
type: SpeciesReference
stoichiometry: 2.0
species: 766398

788370
type: LocalParameter
value: 500.0

788358
type: LocalParameter
value: 0.0

788346
type: LocalParameter
value: 1000.0

788334
type: LocalParameter
value: 0.0

788286
type: SpeciesReference
stoichiometry: 1.0
species: 767633

788226
type: SpeciesReference
stoichiometry: 1.0
species: 767621

788274
type: SpeciesReference
stoichiometry: 1.0
species: 766446

788250
type: SpeciesReference
stoichiometry: 1.0
species: 767803

788262
type: SpeciesReference
stoichiometry: 2.0
species: 766240

828763
type: Reaction
kinetic law: 828823
notes: GENE_ASSOCIATION: (NM_000581.2 or NM_001039848.1 or NM_002085.3 or NM_002574.2 or NM_201397.1 or NM_002083.2 or NM_001039847.1 or NM_181738.1 or NM_181696.1 or NM_181697.1 or NM_005809.4) GENE_LIST: NM_000581.2 NM_001039847.1 NM_001039848.1 NM_002083.2 NM_002085.3 NM_002574.2 NM_005809.4 NM_181696.1 NM_181697.1 NM_181738.1 NM_201397.1 SUBSYSTEM: Glutathione Metabolism
fast: false
reactant: 828775
reactant: 828787
name: glutathione peridoxase
product: 828811
reversible: true
product: 828799

828871
type: LocalParameter
value: 0.0

828859
type: LocalParameter
value: 0.0

828847
type: LocalParameter
value: 1000.0

828835
type: LocalParameter
value: -1000.0

828775
type: SpeciesReference
stoichiometry: 2.0
species: 767743

828787
type: SpeciesReference
stoichiometry: 1.0
species: 767791

828811
type: SpeciesReference
stoichiometry: 2.0
species: 767779

828799
type: SpeciesReference
stoichiometry: 1.0
species: 767731

800760
type: Reaction
kinetic law: 800826
product: 800799
notes: GENE_ASSOCIATION: NM_016308.1 GENE_LIST: NM_016308.1 SUBSYSTEM: Nucleotide Metabolism
fast: false
reactant: 800773
reactant: 800786
name: cytidylate kinase (CMP)
product: 800813
reversible: true

800876
type: LocalParameter
value: 0.0

800864
type: LocalParameter
value: 0.0

800852
type: LocalParameter
value: 1000.0

800839
type: LocalParameter
value: -1000.0

800799
type: SpeciesReference
stoichiometry: 1.0
species: 766240

800773
type: SpeciesReference
stoichiometry: 1.0
species: 766398

800786
type: SpeciesReference
stoichiometry: 1.0
species: 766592

800813
type: SpeciesReference
stoichiometry: 1.0
species: 766458

766071
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: 5-Formiminotetrahydrofolate

832104
type: Reaction
kinetic law: 832140
product: 832128
reactant: 832116
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: heptadecenoate (C17:1, n-8) transport

832189
type: LocalParameter
value: 0.0

832177
type: LocalParameter
value: 0.0

832165
type: LocalParameter
value: 1000.0

832152
type: LocalParameter
value: -1000.0

832128
type: SpeciesReference
stoichiometry: 1.0
species: 765503

832116
type: SpeciesReference
stoichiometry: 1.0
species: 767972

802263
type: Reaction
kinetic law: 802299
product: 802287
reactant: 802275
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Docosapentaenoate (C22:5, n-3)

802348
type: LocalParameter
value: 0.0

802336
type: LocalParameter
value: 0.0

802324
type: LocalParameter
value: 1000.0

802311
type: LocalParameter
value: -1000.0

802287
type: SpeciesReference
stoichiometry: 1.0
species: 766809

802275
type: SpeciesReference
stoichiometry: 1.0
species: 765237

787984
type: Reaction
kinetic law: 788032
product: 788020
product: 788008
reactant: 787996
notes: SUBSYSTEM: Other
fast: false
reversible: false
name: catalase, mitochondrial

788080
type: LocalParameter
value: 500.0

788068
type: LocalParameter
value: 0.0

788056
type: LocalParameter
value: 1000.0

788044
type: LocalParameter
value: 0.0

788020
type: SpeciesReference
stoichiometry: 1.0
species: 770695

788008
type: SpeciesReference
stoichiometry: 2.0
species: 770345

787996
type: SpeciesReference
stoichiometry: 2.0
species: 770357

774232
type: Reaction
kinetic law: 774268
product: 774256
reactant: 774244
fast: false
reversible: true
name: dodecanoate (C12:0) exchange

774317
type: LocalParameter
value: 500.0

774305
type: LocalParameter
value: 0.0

774292
type: LocalParameter
value: 1000.0

774280
type: LocalParameter
value: 0.0

774256
type: SpeciesReference
stoichiometry: 1.0
species: 771960

774244
type: SpeciesReference
stoichiometry: 1.0
species: 765249

822321
type: Reaction
reversible: true
product: 822370
reactant: 822357
product: 822394
reactant: 822345
fast: false
notes: SUBSYSTEM: Folate Metabolism
reactant: 822333
name: formate-tetrahydrofolate ligase
kinetic law: 822406
product: 822382

822370
type: SpeciesReference
stoichiometry: 1.0
species: 765852

822357
type: SpeciesReference
stoichiometry: 1.0
species: 769198

822394
type: SpeciesReference
stoichiometry: 1.0
species: 768800

822345
type: SpeciesReference
stoichiometry: 1.0
species: 767488

822333
type: SpeciesReference
stoichiometry: 1.0
species: 766398

822454
type: LocalParameter
value: 0.0

822442
type: LocalParameter
value: 0.0

822430
type: LocalParameter
value: 1000.0

822418
type: LocalParameter
value: -1000.0

822382
type: SpeciesReference
stoichiometry: 1.0
species: 766240

832321
type: Reaction
reactant: 832346
kinetic law: 832394
product: 832370
fast: false
product: 832382
reversible: false
name: Isocitrate dehydrogenase (NAD+)
product: 832358
notes: GENE_ASSOCIATION: ((NM_005530.2 and NM_174855.1 and NM_174869.1) or (NM_004135.2 and NM_005530.2 and NM_174855.1) or (NM_004135.2 and NM_005530.2 and NM_174856.1) or (NM_004135.2 and NM_005530.2 and NM_006899.2) or (NM_005530.2 and NM_174856.1 and NM_174869.1) or (NM_005530.2 and NM_006899.2 and NM_174869.1)) GENE_LIST: NM_004135.2 NM_005530.2 NM_006899.2 NM_174855.1 NM_174856.1 NM_174869.1 SUBSYSTEM: Citrate Cycle (TCA)
reactant: 832333

832346
type: SpeciesReference
stoichiometry: 1.0
species: 770622

832442
type: LocalParameter
value: 500.0

832430
type: LocalParameter
value: 0.0

832418
type: LocalParameter
value: 1000.0

832406
type: LocalParameter
value: 0.0

832370
type: SpeciesReference
stoichiometry: 1.0
species: 769839

832382
type: SpeciesReference
stoichiometry: 1.0
species: 770634

832358
type: SpeciesReference
stoichiometry: 1.0
species: 769693

832333
type: SpeciesReference
stoichiometry: 1.0
species: 770489

845283
type: Reaction
product: 845331
name: 6-phosphogluconolactonase, endoplasmic reticulum
kinetic law: 845343
notes: GENE_ASSOCIATION: NM_004285.3 GENE_LIST: NM_004285.3 SUBSYSTEM: Pentose Phosphate Pathway
reversible: false
product: 845319
reactant: 845307
reactant: 845295
fast: false

845331
type: SpeciesReference
stoichiometry: 1.0
species: 771444

845391
type: LocalParameter
value: 500.0

845379
type: LocalParameter
value: 0.0

845367
type: LocalParameter
value: 1000.0

845355
type: LocalParameter
value: 0.0

845319
type: SpeciesReference
stoichiometry: 1.0
species: 771288

845307
type: SpeciesReference
stoichiometry: 1.0
species: 771456

845295
type: SpeciesReference
stoichiometry: 1.0
species: 771300

771300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765069
name: 6-phospho-D-glucono-1,5-lactone

819540
type: Reaction
reactant: 819576
notes: GENE_ASSOCIATION: NM_004104.4 GENE_LIST: NM_004104.4 SUBSYSTEM: Fatty acid elongation
kinetic law: 819661
reactant: 819564
reversible: false
name: fatty acid synthase (n-C18:0)
product: 819649
reactant: 819588
product: 819612
product: 819625
reactant: 819552
fast: false
product: 819637
product: 819600

819576
type: SpeciesReference
stoichiometry: 1.0
species: 768154

819710
type: LocalParameter
value: 500.0

819698
type: LocalParameter
value: 0.0

819685
type: LocalParameter
value: 1000.0

819673
type: LocalParameter
value: 0.0

819564
type: SpeciesReference
stoichiometry: 1.0
species: 767827

819649
type: SpeciesReference
stoichiometry: 1.0
species: 768397

819588
type: SpeciesReference
stoichiometry: 2.0
species: 768335

819612
type: SpeciesReference
stoichiometry: 1.0
species: 766616

819625
type: SpeciesReference
stoichiometry: 1.0
species: 767779

819552
type: SpeciesReference
stoichiometry: 3.0
species: 767767

819637
type: SpeciesReference
stoichiometry: 2.0
species: 768323

819600
type: SpeciesReference
stoichiometry: 1.0
species: 766604

833758
type: Reaction
reactant: 833794
reactant: 833770
name: lathosterol oxidase (NADP), endoplasmic reticulum
reversible: false
notes: GENE_ASSOCIATION: (NM_006918.3 or NM_001024956.1) GENE_LIST: NM_001024956.1 NM_006918.3 SUBSYSTEM: Cholesterol Biosynthesis
product: 833843
product: 833831
reactant: 833807
fast: false
kinetic law: 833855
reactant: 833782
product: 833819

833794
type: SpeciesReference
stoichiometry: 1.0
species: 771528

833770
type: SpeciesReference
stoichiometry: 1.0
species: 771444

833843
type: SpeciesReference
stoichiometry: 1.0
species: 771516

833831
type: SpeciesReference
stoichiometry: 2.0
species: 771456

833807
type: SpeciesReference
stoichiometry: 1.0
species: 771540

833904
type: LocalParameter
value: 500.0

833892
type: LocalParameter
value: 0.0

833880
type: LocalParameter
value: 1000.0

833867
type: LocalParameter
value: 0.0

833782
type: SpeciesReference
stoichiometry: 1.0
species: 771480

833819
type: SpeciesReference
stoichiometry: 1.0
species: 771312

831275
type: Reaction
reactant: 831311
reactant: 831287
kinetic law: 831359
product: 831347
name: Hydroxymethylglutaryl CoA synthase
product: 831323
notes: GENE_ASSOCIATION: (NM_001098272.1 or NM_002130.4) GENE_LIST: NM_001098272.1 NM_002130.4 SUBSYSTEM: Cholesterol Metabolism
product: 831335
fast: false
reversible: false
reactant: 831299

831311
type: SpeciesReference
stoichiometry: 1.0
species: 767779

831287
type: SpeciesReference
stoichiometry: 1.0
species: 766144

766144
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765045
name: Acetoacetyl-CoA

831407
type: LocalParameter
value: 500.0

831395
type: LocalParameter
value: 0.0

831383
type: LocalParameter
value: 1000.0

831371
type: LocalParameter
value: 0.0

831347
type: SpeciesReference
stoichiometry: 1.0
species: 767936

831323
type: SpeciesReference
stoichiometry: 1.0
species: 766616

831335
type: SpeciesReference
stoichiometry: 1.0
species: 767767

831299
type: SpeciesReference
stoichiometry: 1.0
species: 766204

778585
type: Reaction
kinetic law: 778621
product: 778609
reactant: 778597
fast: false
reversible: true
name: L-Tryptophan exchange

778669
type: LocalParameter
value: -9.37554999999995E-6

778657
type: LocalParameter
value: 0.0

778645
type: LocalParameter
value: 0.0

778633
type: LocalParameter
value: -1.87510999999999E-5

778609
type: SpeciesReference
stoichiometry: 1.0
species: 772503

778597
type: SpeciesReference
stoichiometry: 1.0
species: 765792

831419
type: Reaction
product: 831479
reversible: false
reactant: 831431
reactant: 831443
kinetic law: 831503
product: 831467
notes: GENE_ASSOCIATION: NM_005518.2 GENE_LIST: NM_005518.2 SUBSYSTEM: Cholesterol Metabolism
product: 831491
reactant: 831455
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false

831479
type: SpeciesReference
stoichiometry: 1.0
species: 770333

831431
type: SpeciesReference
stoichiometry: 1.0
species: 769609

831443
type: SpeciesReference
stoichiometry: 1.0
species: 769657

831551
type: LocalParameter
value: 500.0

831539
type: LocalParameter
value: 0.0

831527
type: LocalParameter
value: 1000.0

831515
type: LocalParameter
value: 0.0

831467
type: SpeciesReference
stoichiometry: 1.0
species: 769851

831491
type: SpeciesReference
stoichiometry: 1.0
species: 770441

831455
type: SpeciesReference
stoichiometry: 1.0
species: 770345

826312
type: Reaction
reactant: 826336
product: 826385
fast: false
product: 826397
reversible: true
product: 826360
kinetic law: 826409
product: 826372
notes: GENE_ASSOCIATION: (NM_005271.1 or NM_012084.3) GENE_LIST: NM_005271.1 NM_012084.3 SUBSYSTEM: Glutamate Metabolism
reactant: 826348
reactant: 826324
name: glutamate dehydrogenase (NAD), mitochondrial

826336
type: SpeciesReference
stoichiometry: 1.0
species: 770345

826385
type: SpeciesReference
stoichiometry: 1.0
species: 770634

826397
type: SpeciesReference
stoichiometry: 1.0
species: 770671

826360
type: SpeciesReference
stoichiometry: 1.0
species: 769693

826457
type: LocalParameter
value: 0.0

826445
type: LocalParameter
value: 0.0

826433
type: LocalParameter
value: 1000.0

826421
type: LocalParameter
value: -1000.0

826372
type: SpeciesReference
stoichiometry: 1.0
species: 770333

826348
type: SpeciesReference
stoichiometry: 1.0
species: 770622

826324
type: SpeciesReference
stoichiometry: 1.0
species: 770261

804183
type: Reaction
reactant: 804195
product: 804268
reactant: 804231
notes: GENE_ASSOCIATION: NM_013402.3 GENE_LIST: NM_013402.3 SUBSYSTEM: Fatty Acid Synthesis
reactant: 804207
reversible: false
name: fatty acyl-CoA desaturase (C20:3CoA, n6 -> C20:4CoA, n6)
reactant: 804219
product: 804255
product: 804243
fast: false
kinetic law: 804280

804195
type: SpeciesReference
stoichiometry: 1.0
species: 767306

804268
type: SpeciesReference
stoichiometry: 1.0
species: 768298

804231
type: SpeciesReference
stoichiometry: 1.0
species: 768359

804207
type: SpeciesReference
stoichiometry: 1.0
species: 767767

804219
type: SpeciesReference
stoichiometry: 1.0
species: 768310

804255
type: SpeciesReference
stoichiometry: 2.0
species: 767779

804243
type: SpeciesReference
stoichiometry: 1.0
species: 767355

804328
type: LocalParameter
value: 500.0

804316
type: LocalParameter
value: 0.0

804304
type: LocalParameter
value: 1000.0

804292
type: LocalParameter
value: 0.0

815306
type: Reaction
reactant: 815342
product: 815390
fast: false
product: 815378
kinetic law: 815426
product: 815414
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_001033859.1 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_000018.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001608.2 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001359.1 and NM_001919.2 and NM_004092.2 and NM_... GENE_LIST: NM_... NM_000018.2 NM_001033859.1 NM_001037811.2 NM_001359.1 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
reactant: 815318
reactant: 815354
reversible: false
name: Beta oxidation of fatty acid
reactant: 815330
reactant: 815366
product: 815402

815342
type: SpeciesReference
stoichiometry: 8.0
species: 770345

815390
type: SpeciesReference
stoichiometry: 5.0
species: 770165

815378
type: SpeciesReference
stoichiometry: 9.0
species: 769657

815474
type: LocalParameter
value: 500.0

815462
type: LocalParameter
value: 0.0

815450
type: LocalParameter
value: 1000.0

815438
type: LocalParameter
value: 0.0

815414
type: SpeciesReference
stoichiometry: 8.0
species: 770634

815318
type: SpeciesReference
stoichiometry: 8.0
species: 769851

815354
type: SpeciesReference
stoichiometry: 8.0
species: 770622

815330
type: SpeciesReference
stoichiometry: 5.0
species: 770153

815366
type: SpeciesReference
stoichiometry: 1.0
species: 770768

770768
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: octadecatrienoyl-CoA (C18:3CoA, n-3)

815402
type: SpeciesReference
stoichiometry: 8.0
species: 770333

853880
type: Reaction
kinetic law: 853916
product: 853904
reactant: 853892
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate transport, diffusion, mitochondrial

853964
type: LocalParameter
value: 0.0

853952
type: LocalParameter
value: 0.0

853940
type: LocalParameter
value: 1000.0

853928
type: LocalParameter
value: -1000.0

853904
type: SpeciesReference
stoichiometry: 1.0
species: 771192

853892
type: SpeciesReference
stoichiometry: 1.0
species: 769198

800381
type: Reaction
reactant: 800393
fast: false
reversible: false
name: cystathionine g-lyase
notes: GENE_ASSOCIATION: (NM_001902.4 or NM_153742.3) GENE_LIST: NM_001902.4 NM_153742.3 SUBSYSTEM: Cysteine Metabolism
product: 800430
kinetic law: 800454
product: 800442
product: 800417
reactant: 800405

800393
type: SpeciesReference
stoichiometry: 1.0
species: 766664

800430
type: SpeciesReference
stoichiometry: 1.0
species: 766652

800503
type: LocalParameter
value: 500.0

800491
type: LocalParameter
value: 0.0

800478
type: LocalParameter
value: 1000.0

800466
type: LocalParameter
value: 0.0

800442
type: SpeciesReference
stoichiometry: 1.0
species: 768347

800417
type: SpeciesReference
stoichiometry: 1.0
species: 765925

800405
type: SpeciesReference
stoichiometry: 1.0
species: 767779

830877
type: Reaction
name: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
reversible: false
product: 830925
kinetic law: 830950
fast: false
product: 830913
reactant: 830901
reactant: 830889
notes: GENE_ASSOCIATION: (NM_014362.2 or NM_198047.1) GENE_LIST: NM_014362.2 NM_198047.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 830938

830925
type: SpeciesReference
stoichiometry: 1.0
species: 769851

830998
type: LocalParameter
value: 500.0

830986
type: LocalParameter
value: 0.0

830974
type: LocalParameter
value: 1000.0

830962
type: LocalParameter
value: 0.0

830913
type: SpeciesReference
stoichiometry: 1.0
species: 769537

830901
type: SpeciesReference
stoichiometry: 1.0
species: 770429

830889
type: SpeciesReference
stoichiometry: 1.0
species: 770345

830938
type: SpeciesReference
stoichiometry: 1.0
species: 770333

830395
type: Reaction
kinetic law: 830431
product: 830419
reactant: 830407
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hexadecenoate (C16:1, n-9) transport

830479
type: LocalParameter
value: 0.0

830467
type: LocalParameter
value: 0.0

830455
type: LocalParameter
value: 1000.0

830443
type: LocalParameter
value: -1000.0

830419
type: SpeciesReference
stoichiometry: 1.0
species: 765467

830407
type: SpeciesReference
stoichiometry: 1.0
species: 767851

814762
type: Reaction
product: 814836
fast: false
reactant: 814823
product: 814860
name: Beta oxidation of fatty acid
product: 814872
reactant: 814774
reversible: false
product: 814848
notes: GENE_ASSOCIATION: ((NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_014049.3 and NM_001919.2 and (NM_000182.3 and NM_000183.1)) or (NM_006111.1 and NM_001608.2 and NM_001919.2 and NM_004092.2 and NM_001037811.2) or (NM_006111.1 and NM_014049.3 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_001033859.1 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_004493.2) or (NM_006111.1 and NM_000018.2 and NM_001919.2 and NM_004092.2 and NM_005327.2) or (NM_001033859.1 and NM_001919.2 and (NM_000182.3 and NM_... GENE_LIST: NM_... NM_000018.2 NM_000182.3 NM_000183.1 NM_001033859.1 NM_001037811.2 NM_001608.2 NM_001919.2 NM_004092.2 NM_004493.2 NM_005327.2 NM_006111.1 NM_014049.3 SUBSYSTEM: Fatty acid oxidation
kinetic law: 814884
reactant: 814811
reactant: 814786
reactant: 814799

814836
type: SpeciesReference
stoichiometry: 9.0
species: 769657

814823
type: SpeciesReference
stoichiometry: 1.0
species: 770805

814860
type: SpeciesReference
stoichiometry: 8.0
species: 770333

814872
type: SpeciesReference
stoichiometry: 8.0
species: 770634

814774
type: SpeciesReference
stoichiometry: 8.0
species: 769851

814848
type: SpeciesReference
stoichiometry: 7.0
species: 770165

814932
type: LocalParameter
value: 500.0

814920
type: LocalParameter
value: 0.0

814908
type: LocalParameter
value: 1000.0

814896
type: LocalParameter
value: 0.0

814811
type: SpeciesReference
stoichiometry: 8.0
species: 770622

814786
type: SpeciesReference
stoichiometry: 7.0
species: 770153

814799
type: SpeciesReference
stoichiometry: 8.0
species: 770345

832587
type: Reaction
reactant: 832611
fast: false
reactant: 832599
reversible: false
kinetic law: 832659
product: 832635
notes: GENE_ASSOCIATION: NM_002168.2 GENE_LIST: NM_002168.2 SUBSYSTEM: Citrate Cycle (TCA)
name: Isocitrate dehydrogenase (NADP+)
product: 832647
product: 832623

832611
type: SpeciesReference
stoichiometry: 1.0
species: 770647

832599
type: SpeciesReference
stoichiometry: 1.0
species: 770489

832708
type: LocalParameter
value: 500.0

832696
type: LocalParameter
value: 0.0

832684
type: LocalParameter
value: 1000.0

832672
type: LocalParameter
value: 0.0

832635
type: SpeciesReference
stoichiometry: 1.0
species: 769839

832647
type: SpeciesReference
stoichiometry: 1.0
species: 770659

832623
type: SpeciesReference
stoichiometry: 1.0
species: 769693

807948
type: Reaction
kinetic law: 808032
product: 807996
product: 808020
reactant: 807960
product: 808008
reactant: 807984
notes: GENE_ASSOCIATION: (NM_203372.1 or NM_203379.1 or NM_001009185.1 or NM_004457.3 or NM_203380.1 or NM_016234.3 or NM_015256.2 or NM_001995.2 or NM_004458.1 or NM_022977.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty acid activation
reversible: true
reactant: 807972
fast: false
name: fatty-acid--CoA ligase (hexadecenoate, C16:1 n-7)

808080
type: LocalParameter
value: 0.0

808068
type: LocalParameter
value: 0.0

808056
type: LocalParameter
value: 1000.0

808044
type: LocalParameter
value: -1000.0

807996
type: SpeciesReference
stoichiometry: 1.0
species: 766338

808020
type: SpeciesReference
stoichiometry: 1.0
species: 768885

807960
type: SpeciesReference
stoichiometry: 1.0
species: 766398

808008
type: SpeciesReference
stoichiometry: 1.0
species: 767864

807984
type: SpeciesReference
stoichiometry: 1.0
species: 767839

807972
type: SpeciesReference
stoichiometry: 1.0
species: 766616

780006
type: Reaction
name: acetyl-CoA carboxylase
product: 780066
product: 780090
product: 780078
product: 780054
reactant: 780042
notes: GENE_ASSOCIATION: (NM_198839.1 or NM_198836.1 or NM_198837.1 or NM_198838.1 or NM_001093.2 or NM_198834.1) GENE_LIST: NM_001093.2 NM_198834.1 NM_198836.1 NM_198837.1 NM_198838.1 NM_198839.1 SUBSYSTEM: Citrate Cycle (TCA)
reactant: 780030
reactant: 780018
reversible: false
kinetic law: 780102
fast: false

780066
type: SpeciesReference
stoichiometry: 1.0
species: 767767

780090
type: SpeciesReference
stoichiometry: 1.0
species: 768800

780078
type: SpeciesReference
stoichiometry: 1.0
species: 768154

780054
type: SpeciesReference
stoichiometry: 1.0
species: 766240

780042
type: SpeciesReference
stoichiometry: 1.0
species: 767803

780030
type: SpeciesReference
stoichiometry: 1.0
species: 766398

780018
type: SpeciesReference
stoichiometry: 1.0
species: 766204

780151
type: LocalParameter
value: 500.0

780138
type: LocalParameter
value: 0.0

780126
type: LocalParameter
value: 1000.0

780114
type: LocalParameter
value: 0.0

786737
type: Reaction
notes: SUBSYSTEM: Other
fast: false
product: 786799
product: 786774
reactant: 786762
reactant: 786749
kinetic law: 786811
reversible: false
name: ATPase, cytosolic
product: 786787

786799
type: SpeciesReference
stoichiometry: 1.0
species: 768800

786774
type: SpeciesReference
stoichiometry: 1.0
species: 765406

786762
type: SpeciesReference
stoichiometry: 1.0
species: 767779

786749
type: SpeciesReference
stoichiometry: 1.0
species: 766398

786860
type: LocalParameter
value: 500.0

786848
type: LocalParameter
value: 0.0

786836
type: LocalParameter
value: 1000.0

786824
type: LocalParameter
value: 0.0

786787
type: SpeciesReference
stoichiometry: 1.0
species: 766240

791609
type: Reaction
product: 791658
name: carnitine docosapentaenoyltransferase (C22:5Crn, n3), mitochondrial
notes: GENE_ASSOCIATION: NM_000098.1 GENE_LIST: NM_000098.1 SUBSYSTEM: Carnitine Shuttle
kinetic law: 791671
reversible: true
fast: false
product: 791646
reactant: 791633
reactant: 791621

791658
type: SpeciesReference
stoichiometry: 1.0
species: 769983

791719
type: LocalParameter
value: 0.0

791707
type: LocalParameter
value: 0.0

791695
type: LocalParameter
value: 1000.0

791683
type: LocalParameter
value: -1000.0

791646
type: SpeciesReference
stoichiometry: 1.0
species: 769851

791633
type: SpeciesReference
stoichiometry: 1.0
species: 769971

769971
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 765057
name: docosapentaenoyl-CoA (C22:5CoA, n-3)

791621
type: SpeciesReference
stoichiometry: 1.0
species: 769863

839167
type: Reaction
kinetic law: 839254
product: 839215
reactant: 839179
product: 839228
fast: false
reversible: false
name: NADH dehydrogenase, mitochondrial
reactant: 839203
notes: GENE_ASSOCIATION: ((NM_018838.3 and NM_015965.3 and MT4535 and MT4536 and MT4537 and MT4538 and MT4539 and MT4540 and MT4541 and NM_004541.2 and NM_004544.2 and NM_175614.2 and NM_002488.2 and NM_004542.1 and NM_002489.2 and NM_005000.2 and NM_002490.3 and NM_005001.1 and NM_014222.2 and NM_005002.3 and NM_005003.2 and NM_004545.3 and NM_004548.1 and NM_019056.2 and NM_004546.2 and NM_002491.1 and NM_004547.4 and NM_002492.2 and NM_182739.1 and NM_004146.4 and NM_005004.2 and NM_005005.1 and NM_002494.2 and NM_004549.3 and NM_005006.5 and NM_004550.3 and NM_004551.1 and NM_002495.1 and NM_004552.1 and NM_004553.3 and NM_024407.3 and NM_002496.1 and NM_007103.2 and NM_021074.1 and NM_001001503.1) or (NM_018838.3 and NM_015965.3 and MT4535 and MT4536 and MT4537 and MT4538 and MT4539 and MT4540 and MT4541 and NM_004541.2 and NM_004544.2 and NM_175614.2 and NM_002488.2 and NM_004542.1 and... GENE_LIST: MT4535 MT4536 MT4537 MT4538 MT4539 MT4540 MT4541 NM_001001503.1 NM_002488.2 NM_002489.2 NM_002490.3 NM_002491.1 NM_002492.2 NM_002494.2 NM_002495.1 NM_002496.1 NM_004146.4 NM_004541.2 NM_004542.1 NM_004542.1and... NM_004544.2 NM_004545.3 NM_004546.2 NM_004547.4 NM_004548.1 NM_004549.3 NM_004550.3 NM_004551.1 NM_004552.1 NM_004553.3 NM_005000.2 NM_005001.1 NM_005002.3 NM_005003.2 NM_005004.2 NM_005005.1 NM_005006.5 NM_007103.2 NM_014222.2 NM_015965.3 NM_018838.3 NM_019056.2 NM_021074.1 NM_024407.3 NM_175614.2 NM_182739.1 SUBSYSTEM: Oxidative Phosphorylation
reactant: 839191
product: 839241

839302
type: LocalParameter
value: 500.0

839290
type: LocalParameter
value: 0.0

839278
type: LocalParameter
value: 1000.0

839266
type: LocalParameter
value: 0.0

839215
type: SpeciesReference
stoichiometry: 4.0
species: 767767

839179
type: SpeciesReference
stoichiometry: 5.0
species: 770333

839228
type: SpeciesReference
stoichiometry: 1.0
species: 770622

839203
type: SpeciesReference
stoichiometry: 1.0
species: 771216

839191
type: SpeciesReference
stoichiometry: 1.0
species: 770634

839241
type: SpeciesReference
stoichiometry: 1.0
species: 771082

807659
type: Reaction
fast: false
reversible: true
reactant: 807683
name: fatty-acid--CoA ligase (heptadecanoate, C15:0)
kinetic law: 807743
notes: GENE_ASSOCIATION: (NM_001995.2 or NM_203372.1 or NM_203379.1 or NM_015256.2 or NM_004457.3 or NM_004458.1 or NM_022977.1 or NM_203380.1 or NM_016234.3 or NM_001009185.1) GENE_LIST: NM_001009185.1 NM_001995.2 NM_004457.3 NM_004458.1 NM_015256.2 NM_016234.3 NM_022977.1 NM_203372.1 NM_203379.1 NM_203380.1 SUBSYSTEM: Fatty Acid Synthesis
product: 807731
reactant: 807671
product: 807719
product: 807707
reactant: 807695

807683
type: SpeciesReference
stoichiometry: 1.0
species: 766616

807791
type: LocalParameter
value: 0.0

807779
type: LocalParameter
value: 0.0

807767
type: LocalParameter
value: 1000.0

807755
type: LocalParameter
value: -1000.0

807731
type: SpeciesReference
stoichiometry: 1.0
species: 768885

807671
type: SpeciesReference
stoichiometry: 1.0
species: 766398

807719
type: SpeciesReference
stoichiometry: 1.0
species: 768739

807707
type: SpeciesReference
stoichiometry: 1.0
species: 766338

807695
type: SpeciesReference
stoichiometry: 1.0
species: 768969

842466
type: Reaction
product: 842502
notes: GENE_ASSOCIATION: (NM_000436.2 or NM_022120.1) GENE_LIST: NM_000436.2 NM_022120.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Degradation
product: 842515
reversible: true
kinetic law: 842527
reactant: 842478
fast: false
name: 3-oxoacid CoA-transferase
reactant: 842490

842502
type: SpeciesReference
stoichiometry: 1.0
species: 769609

842515
type: SpeciesReference
stoichiometry: 1.0
species: 771119

842576
type: LocalParameter
value: 0.0

842564
type: LocalParameter
value: 0.0

842552
type: LocalParameter
value: 1000.0

842539
type: LocalParameter
value: -1000.0

842478
type: SpeciesReference
stoichiometry: 1.0
species: 769645

842490
type: SpeciesReference
stoichiometry: 1.0
species: 771132

852948
type: Reaction
reactant: 852973
product: 852997
kinetic law: 853021
reversible: false
reactant: 852961
notes: GENE_ASSOCIATION: NM_014762.2 GENE_LIST: NM_014762.2 SUBSYSTEM: Cholesterol Metabolism
product: 853009
fast: false
name: delta24-sterol reductase
reactant: 852985

852973
type: SpeciesReference
stoichiometry: 1.0
species: 771444

852997
type: SpeciesReference
stoichiometry: 1.0
species: 771480

853070
type: LocalParameter
value: 500.0

853058
type: LocalParameter
value: 0.0

853046
type: LocalParameter
value: 1000.0

853033
type: LocalParameter
value: 0.0

852961
type: SpeciesReference
stoichiometry: 1.0
species: 771336

853009
type: SpeciesReference
stoichiometry: 1.0
species: 771516

852985
type: SpeciesReference
stoichiometry: 1.0
species: 771528

821863
type: Reaction
product: 821912
reactant: 821888
name: formimidoyltetrahydrofolate cyclodeaminase
notes: GENE_ASSOCIATION: (NM_006657.2 or NM_206965.1) GENE_LIST: NM_006657.2 NM_206965.1 SUBSYSTEM: Histidine Degradation
reversible: true
kinetic law: 821924
fast: false
product: 821900
reactant: 821876

821912
type: SpeciesReference
stoichiometry: 1.0
species: 768347

821888
type: SpeciesReference
stoichiometry: 2.0
species: 767767

821972
type: LocalParameter
value: 0.0

821960
type: LocalParameter
value: 0.0

821948
type: LocalParameter
value: 1000.0

821936
type: LocalParameter
value: -1000.0