MODEL1109160001
type: SBMLModel
species: COPASI32
species: COPASI27
species: COPASI26
species: COPASI36
is described by: http://identifiers.org/pubmed/11248291
reaction: COPASI43
species: COPASI5
curated: false
species: COPASI24
reaction: COPASI53
notes: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer toCC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use:Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: COPASI58
reaction: COPASI50
reaction: COPASI56
reaction: COPASI63
species: COPASI17
substance units: 687672
reaction: COPASI42
reaction: COPASI47
area units: 076543
species: COPASI8
species: 136765
species: COPASI34
length unit: 076567
units def: 687647
species: COPASI33
species: COPASI38
species: COPASI37
reaction: COPASI45
species: COPASI6
species: COPASI10
species: COPASI14
reaction: COPASI39
reaction: COPASI52
name: Kogan2001_aPTT_coagulation
species: COPASI12
species: COPASI28
reaction: COPASI49
reaction: COPASI55
units def: 687672
reaction: COPASI62
species: COPASI3
species: 136767
species: COPASI18
reaction: COPASI41
species: COPASI35
species: COPASI9
reaction: COPASI65
reaction: COPASI60
name: Henri-Michaelis-Menten (irreversible, kcat)
species: COPASI30
species: COPASI2
reaction: COPASI44
function def: COPASI66
species: COPASI11
species: COPASI21
species: 136763
species: COPASI15
species: COPASI25
reaction: COPASI59
species: COPASI13
reaction: COPASI51
reaction: COPASI57
species: COPASI20
reaction: COPASI64
species: COPASI4
species: COPASI19
species: COPASI29
reaction: COPASI48
volume units: MODEL1105180000#
reaction: COPASI54
species: COPASI16
reaction: COPASI61
compartment: 136245
time units: 687647
reaction: COPASI40
species: COPASI31
species: COPASI7
reaction: COPASI46

COPASI32
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.132999993595302
initial amount: NaN
in compartment: 136245
name: X

136245
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment_1

COPASI27
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 5.85948E-5
initial amount: NaN
in compartment: 136245
name: PAI1

COPASI26
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.888
initial amount: NaN
in compartment: 136245
name: alpha2AP

COPASI36
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 8.29999960030832
initial amount: NaN
in compartment: 136245
name: I

COPASI43
type: Reaction
kinetic law: 687925
modifier: 687913
product: 687901
reactant: 687889
fast: false
reversible: false
name: R11

137058
type: LocalParameter
value: 0.058
name: Km

137056
type: LocalParameter
value: 2.25
name: kcat

COPASI5
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa

687901
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

COPASI10
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IIa

687889
type: SpeciesReference
stoichiometry: 1.0
species: COPASI33

COPASI33
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.39999993258213
initial amount: NaN
in compartment: 136245
name: II

COPASI24
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_alpha1AT

COPASI53
type: Reaction
kinetic law: 688405
product: 688393
reactant: 688381
reactant: 688369
fast: false
reversible: false
name: R21

137080
type: LocalParameter
value: 0.0293
name: k1

688393
type: SpeciesReference
stoichiometry: 1.0
species: COPASI14

COPASI14
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IIa_alpha2M

688381
type: SpeciesReference
stoichiometry: 1.0
species: COPASI15

COPASI15
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.25
initial amount: NaN
in compartment: 136245
name: alpha2M

688369
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

COPASI58
type: Reaction
kinetic law: 688648
product: 688636
reactant: 688624
reactant: 688612
fast: false
reversible: false
name: R26

137088
type: LocalParameter
value: 0.001
name: k1

688636
type: SpeciesReference
stoichiometry: 1.0
species: COPASI23

COPASI23
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_C1inh

688624
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21

COPASI21
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.27
initial amount: NaN
in compartment: 136245
name: C1inh

688612
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

COPASI22
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00496
initial amount: NaN
in compartment: 136245
name: XIa

COPASI50
type: Reaction
kinetic law: 688261
product: 688249
reactant: 688237
reactant: 688225
fast: false
reversible: false
name: R18

137076
type: LocalParameter
value: 10000.0
name: k1

688249
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI8
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: VIIIa_IXa

688237
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

COPASI6
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IXa

688225
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

COPASI7
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: VIIIa

COPASI56
type: Reaction
kinetic law: 688551
product: 688540
reactant: 688527
reactant: 688515
fast: false
reversible: false
name: R24

137085
type: LocalParameter
value: 960.0
name: k1

688540
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

COPASI19
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa_TFPI

688527
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

COPASI18
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.00249999987961094
initial amount: NaN
in compartment: 136245
name: TFPI

688515
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

COPASI63
type: Reaction
kinetic law: 688888
product: 688876
reactant: 688864
reactant: 688852
fast: false
reversible: false
name: Va_Xa inactivation by ATIII

137095
type: LocalParameter
value: 0.11
name: k1

688876
type: SpeciesReference
stoichiometry: 1.0
species: 136763

136763
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Va_Xa_ATIII

688864
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

COPASI9
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.39999983627088
initial amount: NaN
in compartment: 136245
name: ATIII

688852
type: SpeciesReference
stoichiometry: 1.0
species: COPASI4

COPASI4
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Va_Xa

COPASI17
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa_alpha1AT

687672
type: SBMLUnitsDef
unit: 687684
name: substance

687684
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

COPASI42
type: Reaction
kinetic law: 687877
modifier: 687865
product: 687853
reactant: 687841
fast: false
reversible: false
name: R10

137055
type: LocalParameter
value: 0.19
name: Km

137053
type: LocalParameter
value: 1740.0
name: kcat

687853
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

687841
type: SpeciesReference
stoichiometry: 1.0
species: COPASI32

COPASI47
type: Reaction
kinetic law: 688117
modifier: 688105
product: 688093
reactant: 688081
fast: false
reversible: false
name: R15

137070
type: LocalParameter
value: 0.02
name: Km

137068
type: LocalParameter
value: 60.0
name: kcat

688093
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

688081
type: SpeciesReference
stoichiometry: 1.0
species: COPASI35

COPASI35
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 6.99999966291063E-4
initial amount: NaN
in compartment: 136245
name: VIII

136765
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Va_Xa_alpha1AT

COPASI34
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0209999989887319
initial amount: NaN
in compartment: 136245
name: V

687647
type: SBMLUnitsDef
unit: 687659
name: time

687659
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

COPASI38
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa_Va

COPASI37
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Ia

COPASI45
type: Reaction
kinetic law: 688021
modifier: 688009
product: 687997
reactant: 687985
fast: false
reversible: false
name: R13

137064
type: LocalParameter
value: 0.0717
name: Km

137062
type: LocalParameter
value: 14.0
name: kcat

687997
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

COPASI3
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Va

687985
type: SpeciesReference
stoichiometry: 1.0
species: COPASI34

COPASI39
type: Reaction
kinetic law: 687732
modifier: 687720
product: 687708
reactant: 687696
fast: false
reversible: false
name: R6

137046
type: LocalParameter
value: 2.0
name: Km

137044
type: LocalParameter
value: 0.68
name: kcat

COPASI2
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.173
initial amount: NaN
in compartment: 136245
name: XIIa

687708
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

687696
type: SpeciesReference
stoichiometry: 1.0
species: COPASI30

COPASI30
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0174
initial amount: NaN
in compartment: 136245
name: XI

COPASI52
type: Reaction
kinetic law: 688357
product: 688345
reactant: 688333
reactant: 688321
fast: false
reversible: false
name: R20

137079
type: LocalParameter
value: 0.0047
name: k1

688345
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

COPASI12
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IIa_alpha1AT

688333
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

COPASI13
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 24.4999988201872
initial amount: NaN
in compartment: 136245
name: alpha1AT

688321
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

COPASI28
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_PAI1

COPASI49
type: Reaction
kinetic law: 688213
product: 688201
reactant: 688189
reactant: 688177
fast: false
reversible: false
name: R17

137074
type: LocalParameter
value: 10000.0
name: k1

688201
type: SpeciesReference
stoichiometry: 1.0
species: COPASI4

688189
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

688177
type: SpeciesReference
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species: COPASI3

COPASI55
type: Reaction
kinetic law: 688503
product: 688492
reactant: 688479
reactant: 688467
fast: false
reversible: false
name: R23

137083
type: LocalParameter
value: 0.0157
name: k1

688492
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

688479
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

688467
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

COPASI62
type: Reaction
kinetic law: 688840
product: 688828
reactant: 688816
reactant: 688804
fast: false
reversible: false
name: R30

137094
type: LocalParameter
value: 12.6
name: k1

688828
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

688816
type: SpeciesReference
stoichiometry: 1.0
species: COPASI27

688804
type: SpeciesReference
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species: COPASI22

136767
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IXa_VIIIa_ATIII

COPASI41
type: Reaction
kinetic law: 687829
modifier: 687817
product: 687805
reactant: 687793
fast: false
reversible: false
name: R9

137052
type: LocalParameter
value: 2.0
name: Km

137050
type: LocalParameter
value: 0.04
name: kcat

687805
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

687793
type: SpeciesReference
stoichiometry: 1.0
species: COPASI32

COPASI65
type: Reaction
kinetic law: 688985
product: 688973
reactant: 688961
reactant: 688948
fast: false
reversible: false
name: VIIIa-IXa inactivation by ATIII

137098
type: LocalParameter
value: 0.0294
name: k1

688973
type: SpeciesReference
stoichiometry: 1.0
species: 136767

688961
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

688948
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI60
type: Reaction
kinetic law: 688744
product: 688732
reactant: 688720
reactant: 688708
fast: false
reversible: false
name: R28

137091
type: LocalParameter
value: 0.01
name: k1

688732
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

COPASI29
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_ATIII

688720
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

688708
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

COPASI44
type: Reaction
kinetic law: 687973
modifier: 687961
product: 687949
reactant: 687937
fast: false
reversible: false
name: R12

137061
type: LocalParameter
value: 1.0
name: Km

137059
type: LocalParameter
value: 200.0
name: kcat

687949
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

687937
type: SpeciesReference
stoichiometry: 1.0
species: COPASI33

COPASI11
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IIa_ATIII

COPASI25
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: XIa_alpha2AP

COPASI59
type: Reaction
kinetic law: 688696
product: 688684
reactant: 688672
reactant: 688660
fast: false
reversible: false
name: R27

137089
type: LocalParameter
value: 0.004
name: k1

688684
type: SpeciesReference
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species: COPASI24

688672
type: SpeciesReference
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species: COPASI13

688660
type: SpeciesReference
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species: COPASI22

COPASI51
type: Reaction
kinetic law: 688309
product: 688297
reactant: 688285
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fast: false
reversible: false
name: R19

137077
type: LocalParameter
value: 0.35
name: k1

688297
type: SpeciesReference
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species: COPASI11

688285
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species: COPASI9

688273
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species: COPASI10

COPASI57
type: Reaction
kinetic law: 688600
product: 688588
reactant: 688576
reactant: 688564
fast: false
reversible: false
name: R25

137086
type: LocalParameter
value: 0.0294
name: k1

688588
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

COPASI20
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: IXa_ATIII

688576
type: SpeciesReference
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species: COPASI9

688564
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

COPASI64
type: Reaction
kinetic law: 688936
product: 688924
reactant: 688912
reactant: 688900
fast: false
reversible: false
name: Va_Xa inactivation by alpha1AT

137097
type: LocalParameter
value: 0.0157
name: k1

688924
type: SpeciesReference
stoichiometry: 1.0
species: 136765

688912
type: SpeciesReference
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species: COPASI13

688900
type: SpeciesReference
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species: COPASI4

COPASI48
type: Reaction
kinetic law: 688165
modifier: 688153
product: 688141
reactant: 688129
fast: false
reversible: false
name: R16

137073
type: LocalParameter
value: 7.2
name: Km

137071
type: LocalParameter
value: 5040.0
name: kcat

688141
type: SpeciesReference
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species: COPASI37

688129
type: SpeciesReference
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species: COPASI36

COPASI54
type: Reaction
kinetic law: 688455
product: 688442
reactant: 688430
reactant: 688417
fast: false
reversible: false
name: R22

137082
type: LocalParameter
value: 0.11
name: k1

688442
type: SpeciesReference
stoichiometry: 1.0
species: COPASI16

COPASI16
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 136245
name: Xa_ATIII

688430
type: SpeciesReference
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species: COPASI9

688417
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species: COPASI5

COPASI61
type: Reaction
kinetic law: 688792
product: 688780
reactant: 688768
reactant: 688756
fast: false
reversible: false
name: R29

137092
type: LocalParameter
value: 0.03
name: k1

688780
type: SpeciesReference
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species: COPASI25

688768
type: SpeciesReference
stoichiometry: 1.0
species: COPASI26

688756
type: SpeciesReference
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species: COPASI22

COPASI40
type: Reaction
kinetic law: 687781
modifier: 687768
product: 687756
reactant: 687744
fast: false
reversible: false
name: R8

137049
type: LocalParameter
value: 0.35
name: Km

137047
type: LocalParameter
value: 225.0
name: kcat

687756
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

687744
type: SpeciesReference
stoichiometry: 1.0
species: COPASI31

COPASI31
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0899999956659938
initial amount: NaN
in compartment: 136245
name: IX

COPASI46
type: Reaction
kinetic law: 688069
modifier: 688057
product: 688045
reactant: 688033
fast: false
reversible: false
name: R14

137067
type: LocalParameter
value: 0.0104
name: Km

137065
type: LocalParameter
value: 2.6
name: kcat

688045
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

688033
type: SpeciesReference
stoichiometry: 1.0
species: COPASI34

W3 CDTF: Fri Sep 16 11:09:04 BST 2011

W3 CDTF: Fri Sep 16 11:09:38 BST 2011

W3 CDTF: Fri Sep 16 11:09:38 BST 2011

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

W3 CDTF: Fri Sep 16 11:09:38 BST 2011

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert