MODEL1109160000
type: SBMLModel
reaction: COPASI34
species: COPASI15
reaction: COPASI46
species: COPASI14
species: COPASI19
compartment: 078689
species: COPASI18
volume units: MODEL1105180000#
reaction: COPASI52
species: COPASI6
reaction: COPASI44
species: COPASI25
species: COPASI2
length unit: 076567
reaction: COPASI54
time units: 680925
species: COPASI23
reaction: COPASI38
curated: false
reaction: COPASI33
species: COPASI28
species: COPASI20
reaction: COPASI39
notes: This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer toCC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use:Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
reaction: COPASI35
species: COPASI9
creator:
  ORG:
    orgname: EBI
  n:
    given: Michael
    family: Schubert
reaction: COPASI41
units def: 680925
reaction: COPASI48
species: COPASI16
species: COPASI26
modified:
  W3 CDTF: Fri Sep 16 11:08:34 BST 2011
species: COPASI7
reaction: COPASI51
species: COPASI30
name: Kogan2001_aPTT_preincubation
species: COPASI3
reaction: COPASI43
creator:
  ORG:
    orgname: EBI
  n:
    given: Michael
    family: Schubert
created:
  W3 CDTF: Fri Sep 16 11:08:07 BST 2011
reaction: COPASI56
species: COPASI13
species: COPASI29
reaction: COPASI53
species: COPASI21
species: COPASI31
species: COPASI4
reaction: COPASI37
reaction: COPASI32
species: COPASI11
species: COPASI10
species: COPASI27
area units: 076543
modified:
  W3 CDTF: Fri Sep 16 11:08:34 BST 2011
reaction: COPASI40
units def: 680949
reaction: COPASI47
reaction: COPASI50
reaction: COPASI45
name: Henri-Michaelis-Menten (irreversible, kcat)
reaction: COPASI42
species: COPASI24
creator:
  ORG:
    orgname: EBI
  n:
    given: Michael
    family: Schubert
substance units: 680949
reaction: COPASI55
function def: COPASI57
species: COPASI5
is described by: http://identifiers.org/pubmed/11248291
species: COPASI12
species: COPASI22
reaction: COPASI36
species: COPASI17
modified:
  W3 CDTF: Fri Sep 16 11:08:34 BST 2011
reaction: COPASI49
species: COPASI8

COPASI34
type: Reaction
kinetic law: 681115
modifier: 681102
product: 681089
reactant: 681076
fast: false
reversible: false
name: R3

079609
type: LocalParameter
value: 37.0
name: Km

079608
type: LocalParameter
value: 2400.0
name: kcat

COPASI21
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIf

078689
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment_1

681089
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

COPASI25
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K

681076
type: SpeciesReference
stoichiometry: 1.0
species: COPASI30

COPASI30
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.579999972069738
initial amount: NaN
in compartment: 078689
name: PK

COPASI15
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_ATIII

COPASI46
type: Reaction
kinetic law: 681705
product: 681693
reactant: 681680
reactant: 681668
fast: false
reversible: false
name: R33

079633
type: LocalParameter
value: 0.005
name: k1

681693
type: SpeciesReference
stoichiometry: 1.0
species: COPASI18

COPASI18
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_alpha2M

681680
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

COPASI6
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.49999983145531
initial amount: NaN
in compartment: 078689
name: alpha2M

681668
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

COPASI3
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 2.3E-9
initial amount: NaN
in compartment: 078689
name: XIIa

COPASI14
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_PAI1

COPASI19
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_ATIII

COPASI52
type: Reaction
kinetic law: 681995
product: 681983
reactant: 681971
reactant: 681959
fast: false
reversible: false
name: R39

079641
type: LocalParameter
value: 1.0
name: k1

681983
type: SpeciesReference
stoichiometry: 1.0
species: COPASI26

COPASI26
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K_C1inh

681971
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

COPASI7
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1.69999991813544
initial amount: NaN
in compartment: 078689
name: C1inh

681959
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

COPASI44
type: Reaction
kinetic law: 681607
product: 681595
reactant: 681583
reactant: 681571
fast: false
reversible: false
name: R31

079630
type: LocalParameter
value: 0.046
name: k1

681595
type: SpeciesReference
stoichiometry: 1.0
species: COPASI16

COPASI16
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_C1inh

681583
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

681571
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

COPASI2
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.299999985553313
initial amount: NaN
in compartment: 078689
name: XII

COPASI54
type: Reaction
kinetic law: 682091
product: 682079
reactant: 682067
reactant: 682055
fast: false
reversible: false
name: R41

079644
type: LocalParameter
value: 3.6
name: k1

682079
type: SpeciesReference
stoichiometry: 1.0
species: COPASI28

COPASI28
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K_PAI1

682067
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

COPASI13
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 4.59999977848413E-4
initial amount: NaN
in compartment: 078689
name: PAI1

682055
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

680925
type: SBMLUnitsDef
unit: 680937
name: time

680937
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

COPASI23
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIf_alpha2AP

COPASI38
type: Reaction
kinetic law: 681318
modifier: 681306
product: 681294
reactant: 681282
fast: false
reversible: false
name: R7

079621
type: LocalParameter
value: 0.5
name: Km

079619
type: LocalParameter
value: 34.0
name: kcat

COPASI8
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa

681294
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

681282
type: SpeciesReference
stoichiometry: 1.0
species: COPASI2

COPASI33
type: Reaction
kinetic law: 681063
modifier: 681050
product: 681037
reactant: 681024
fast: false
reversible: false
name: R2

079607
type: LocalParameter
value: 0.091
name: Km

079606
type: LocalParameter
value: 216.0
name: kcat

681037
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

681024
type: SpeciesReference
stoichiometry: 1.0
species: COPASI30

COPASI20
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_PAI1

COPASI39
type: Reaction
kinetic law: 681366
product: 681354
reactant: 681342
reactant: 681330
fast: false
reversible: false
name: R26

079623
type: LocalParameter
value: 0.001
name: k1

681354
type: SpeciesReference
stoichiometry: 1.0
species: COPASI9

COPASI9
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_C1inh

681342
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

681330
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI35
type: Reaction
kinetic law: 681167
modifier: 681154
product: 681141
reactant: 681128
fast: false
reversible: false
name: R4

079611
type: LocalParameter
value: 0.51
name: Km

079610
type: LocalParameter
value: 342.0
name: kcat

681141
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

681128
type: SpeciesReference
stoichiometry: 1.0
species: COPASI2

COPASI41
type: Reaction
kinetic law: 681463
product: 681451
reactant: 681439
reactant: 681426
fast: false
reversible: false
name: R28

079625
type: LocalParameter
value: 0.01
name: k1

681451
type: SpeciesReference
stoichiometry: 1.0
species: COPASI15

681439
type: SpeciesReference
stoichiometry: 1.0
species: COPASI4

COPASI4
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 3.39999983627088
initial amount: NaN
in compartment: 078689
name: ATIII

681426
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI48
type: Reaction
kinetic law: 681801
product: 681789
reactant: 681777
reactant: 681765
fast: false
reversible: false
name: R35

079636
type: LocalParameter
value: 0.96
name: k1

681789
type: SpeciesReference
stoichiometry: 1.0
species: COPASI20

681777
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

681765
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

COPASI51
type: Reaction
kinetic law: 681947
product: 681935
reactant: 681923
reactant: 681911
fast: false
reversible: false
name: R38

079640
type: LocalParameter
value: 0.0032
name: k1

681935
type: SpeciesReference
stoichiometry: 1.0
species: COPASI24

COPASI24
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIf_ATIII

681923
type: SpeciesReference
stoichiometry: 1.0
species: COPASI4

681911
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21

COPASI43
type: Reaction
kinetic law: 681559
product: 681547
reactant: 681535
reactant: 681523
fast: false
reversible: false
name: R30

079628
type: LocalParameter
value: 12.6
name: k1

681547
type: SpeciesReference
stoichiometry: 1.0
species: COPASI14

681535
type: SpeciesReference
stoichiometry: 1.0
species: COPASI13

681523
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI56
type: Reaction
kinetic law: 682163
reactant: 682151
fast: false
reversible: false
name: XIa degradation

079647
type: LocalParameter
value: 0.0
name: k1

682151
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

COPASI29
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K_ATIII

COPASI53
type: Reaction
kinetic law: 682043
product: 682031
reactant: 682019
reactant: 682007
fast: false
reversible: false
name: R40

079643
type: LocalParameter
value: 0.29
name: k1

682031
type: SpeciesReference
stoichiometry: 1.0
species: COPASI27

COPASI27
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: K_alpha2M

682019
type: SpeciesReference
stoichiometry: 1.0
species: COPASI6

682007
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

COPASI31
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0249999987961094
initial amount: NaN
in compartment: 078689
name: XI

COPASI37
type: Reaction
kinetic law: 681270
modifier: 681258
product: 681245
reactant: 681232
fast: false
reversible: false
name: R6

079617
type: LocalParameter
value: 2.0
name: Km

079615
type: LocalParameter
value: 0.68
name: kcat

681245
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

681232
type: SpeciesReference
stoichiometry: 1.0
species: COPASI31

COPASI32
type: Reaction
kinetic law: 681011
modifier: 680999
product: 680986
reactant: 680974
fast: false
reversible: false
name: R1

079605
type: LocalParameter
value: 11.0
name: Km

079604
type: LocalParameter
value: 1.98
name: kcat

680986
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

680974
type: SpeciesReference
stoichiometry: 1.0
species: COPASI2

COPASI11
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_alpha2AP

COPASI10
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIa_alpha1AT

COPASI40
type: Reaction
kinetic law: 681414
product: 681402
reactant: 681390
reactant: 681378
fast: false
reversible: false
name: R27

079624
type: LocalParameter
value: 0.004
name: k1

681402
type: SpeciesReference
stoichiometry: 1.0
species: COPASI10

681390
type: SpeciesReference
stoichiometry: 1.0
species: COPASI5

COPASI5
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 24.4999988201872
initial amount: NaN
in compartment: 078689
name: alpha1AT

681378
type: SpeciesReference
stoichiometry: 1.0
species: COPASI8

680949
type: SBMLUnitsDef
unit: 680961
name: substance

680961
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

COPASI47
type: Reaction
kinetic law: 681753
product: 681741
reactant: 681729
reactant: 681717
fast: false
reversible: false
name: R34

079634
type: LocalParameter
value: 0.0013
name: k1

681741
type: SpeciesReference
stoichiometry: 1.0
species: COPASI19

681729
type: SpeciesReference
stoichiometry: 1.0
species: COPASI4

681717
type: SpeciesReference
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species: COPASI3

COPASI50
type: Reaction
kinetic law: 681899
product: 681887
reactant: 681875
reactant: 681862
fast: false
reversible: false
name: R37

079638
type: LocalParameter
value: 0.0091
name: k1

681887
type: SpeciesReference
stoichiometry: 1.0
species: COPASI23

681875
type: SpeciesReference
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species: COPASI12

COPASI12
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.899999956659938
initial amount: NaN
in compartment: 078689
name: alpha2AP

681862
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21

COPASI45
type: Reaction
kinetic law: 681656
product: 681644
reactant: 681632
reactant: 681619
fast: false
reversible: false
name: R32

079631
type: LocalParameter
value: 0.011
name: k1

681644
type: SpeciesReference
stoichiometry: 1.0
species: COPASI17

COPASI17
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 078689
name: XIIa_alpha2AP

681632
type: SpeciesReference
stoichiometry: 1.0
species: COPASI12

681619
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

COPASI42
type: Reaction
kinetic law: 681511
product: 681499
reactant: 681487
reactant: 681475
fast: false
reversible: false
name: R29

079627
type: LocalParameter
value: 0.03
name: k1

681499
type: SpeciesReference
stoichiometry: 1.0
species: COPASI11

681487
type: SpeciesReference
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species: COPASI12

681475
type: SpeciesReference
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species: COPASI8

COPASI55
type: Reaction
kinetic law: 682139
product: 682127
reactant: 682115
reactant: 682103
fast: false
reversible: false
name: R42

079646
type: LocalParameter
value: 0.0096
name: k1

682127
type: SpeciesReference
stoichiometry: 1.0
species: COPASI29

682115
type: SpeciesReference
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species: COPASI4

682103
type: SpeciesReference
stoichiometry: 1.0
species: COPASI25

COPASI22
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
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name: XIIf_C1inh

COPASI36
type: Reaction
kinetic law: 681219
modifier: 681206
product: 681193
reactant: 681180
fast: false
reversible: false
name: R5

079613
type: LocalParameter
value: 0.5
name: Km

079612
type: LocalParameter
value: 0.34
name: kcat

681193
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21

681180
type: SpeciesReference
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species: COPASI3

COPASI49
type: Reaction
kinetic law: 681850
product: 681838
reactant: 681826
reactant: 681813
fast: false
reversible: false
name: R36

079637
type: LocalParameter
value: 0.185
name: k1

681838
type: SpeciesReference
stoichiometry: 1.0
species: COPASI22

681826
type: SpeciesReference
stoichiometry: 1.0
species: COPASI7

681813
type: SpeciesReference
stoichiometry: 1.0
species: COPASI21