MODEL1109150002
type: SBMLModel
parameter: COPASI8
parameter: 687309
reaction: COPASI43
reaction: COPASI36
reaction: COPASI46
length unit: 076567
parameter: COPASI4
species: 686383
reaction: COPASI41
reaction: COPASI32
parameter: 687243
parameter: 687282
parameter: 687264
parameter: 687327
species: 686323
reaction: COPASI27
parameter: 687348
reaction: COPASI17
parameter: 687321
reaction: COPASI55
reaction: COPASI48
reaction: COPASI23
species: 686329
species: 686367
parameter: 687237
reaction: COPASI53
reaction: COPASI44
species: 686320
species: 686335
species: 686373
parameter: 687303
parameter: 687294
parameter: 687339
species: 686372
time units: MODEL1105180000#
reaction: COPASI39
reaction: COPASI19
parameter: 687288
species: 686379
volume units: MODEL1105180000#
parameter: 687333
reaction: COPASI25
reaction: COPASI35
area units: 076543
parameter: 687249
parameter: 687354
curated: false
species: 686319
reaction: COPASI56
reaction: COPASI30
species: COPASI2
parameter: COPASI12
reaction: COPASI21
parameter: 687270
parameter: 687315
species: 686304
reaction: COPASI51
parameter: 687279
parameter: 687324
species: 686314
species: 686387
parameter: COPASI9
parameter: 687345
is described by: http://identifiers.org/pubmed/7592704
reaction: COPASI37
species: 686300
species: 686374
reaction: COPASI58
parameter: COPASI5
parameter: 687234
parameter: 687306
species: 686310
reaction: COPASI42
reaction: COPASI33
species: 686359
parameter: 687255
name: Leipold1995_ThrombinFormation+inhibitors
species: 686333
parameter: COPASI10

COPASI8
type: Parameter
constant: true
value: 100.0
name: k48

687309
type: Parameter
constant: true
value: 0.1
name: k27

COPASI43
type: Reaction
kinetic law: 674390
product: 674378
reactant: 674366
reactant: 674354
fast: false
reversible: true
name: IIa-V binding

674378
type: SpeciesReference
stoichiometry: 1.0
species: 686368

686368
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IIa_V

686298
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: compartment

674366
type: SpeciesReference
stoichiometry: 1.0
species: 686330

686330
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 20.0
initial amount: NaN
in compartment: 686298
name: V

674354
type: SpeciesReference
stoichiometry: 1.0
species: 686362

686362
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IIa

COPASI36
type: Reaction
kinetic law: 674066
product: 674054
reactant: 674042
reactant: 674030
fast: false
reversible: true
name: Va_Xa-mIIa binding

674054
type: SpeciesReference
stoichiometry: 1.0
species: 686358

686358
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa_mIIa

674042
type: SpeciesReference
stoichiometry: 1.0
species: 686359

686359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: mIIa

674030
type: SpeciesReference
stoichiometry: 1.0
species: 686338

686338
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa

COPASI46
type: Reaction
kinetic law: 674534
product: 674522
product: 674510
reactant: 674498
fast: false
reversible: false
name: IIa-VIII activation

674522
type: SpeciesReference
stoichiometry: 1.0
species: 686319

686319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)

674510
type: SpeciesReference
stoichiometry: 1.0
species: 686362

674498
type: SpeciesReference
stoichiometry: 1.0
species: 686369

686369
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IIa_VIII

COPASI4
type: Parameter
constant: true
value: 0.9
name: k44

686383
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa_I

COPASI41
type: Reaction
kinetic law: 674295
product: 674282
reactant: 674270
reactant: 674258
fast: false
reversible: true
name: mIIa-VIII binding

674282
type: SpeciesReference
stoichiometry: 1.0
species: 686367

686367
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: mIIa_VIII

674270
type: SpeciesReference
stoichiometry: 1.0
species: 686313

686313
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.7
initial amount: NaN
in compartment: 686298
name: VIII

674258
type: SpeciesReference
stoichiometry: 1.0
species: 686359

COPASI32
type: Reaction
kinetic law: 673874
product: 673862
reactant: 673850
reactant: 673838
fast: false
reversible: true
name: Xa-VIII binding

673862
type: SpeciesReference
stoichiometry: 1.0
species: 686335

686335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Xa_VIII

673850
type: SpeciesReference
stoichiometry: 1.0
species: 686313

673838
type: SpeciesReference
stoichiometry: 1.0
species: 686310

686310
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Xa

687243
type: Parameter
constant: true
value: 5.5
name: k5

687282
type: Parameter
constant: true
value: 0.0011
name: k18

687264
type: Parameter
constant: true
value: 19.0
name: k12

687327
type: Parameter
constant: true
value: 0.1
name: k33

686323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)_IXa_X

COPASI27
type: Reaction
kinetic law: 673657
product: 673645
product: 673633
reactant: 673621
fast: false
reversible: false
name: VIIIa(IIa)_IXa inactivation

673645
type: SpeciesReference
stoichiometry: 1.0
species: 686305

686305
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IXa

673633
type: SpeciesReference
stoichiometry: 1.0
species: 686329

686329
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)*

673621
type: SpeciesReference
stoichiometry: 1.0
species: 686320

686320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)_IXa

687348
type: Parameter
constant: true
value: 7.2
name: k40

COPASI17
type: Reaction
kinetic law: 673176
product: 673164
product: 673152
reactant: 673140
fast: false
reversible: false
name: TF_VIIa-X activation

673164
type: SpeciesReference
stoichiometry: 1.0
species: 686310

673152
type: SpeciesReference
stoichiometry: 1.0
species: 686303

686303
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0043
initial amount: NaN
in compartment: 686298
name: TF_VIIa

673140
type: SpeciesReference
stoichiometry: 1.0
species: 686308

686308
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: TF_VIIa_X

687321
type: Parameter
constant: true
value: 66.0
name: k31

COPASI55
type: Reaction
kinetic law: 674967
product: 674955
reactant: 674943
reactant: 674931
fast: false
reversible: true
name: Xa inhibition

674955
type: SpeciesReference
stoichiometry: 1.0
species: 686382

686382
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Xa_I

674943
type: SpeciesReference
stoichiometry: 1.0
species: 686372

686372
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 10.0
initial amount: NaN
in compartment: 686298
name: I

674931
type: SpeciesReference
stoichiometry: 1.0
species: 686310

COPASI48
type: Reaction
kinetic law: 674630
product: 674618
reactant: 674606
reactant: 674594
fast: false
reversible: true
name: IXa inhibition

674618
type: SpeciesReference
stoichiometry: 1.0
species: 686374

686374
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IXa_I

674606
type: SpeciesReference
stoichiometry: 1.0
species: 686372

674594
type: SpeciesReference
stoichiometry: 1.0
species: 686305

COPASI23
type: Reaction
kinetic law: 673465
product: 673453
reactant: 673441
reactant: 673429
fast: false
reversible: true
name: VIIIa(IIa)_IXa-X binding

673453
type: SpeciesReference
stoichiometry: 1.0
species: 686324

686324
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)_IXa_X

673441
type: SpeciesReference
stoichiometry: 1.0
species: 686309

686309
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 170.0
initial amount: NaN
in compartment: 686298
name: X

673429
type: SpeciesReference
stoichiometry: 1.0
species: 686320

687237
type: Parameter
constant: true
value: 0.47
name: k3

COPASI53
type: Reaction
kinetic law: 674871
product: 674859
reactant: 674847
reactant: 674835
fast: false
reversible: true
name: VIIIa(Xa)_IXa inhibition

674859
type: SpeciesReference
stoichiometry: 1.0
species: 686378

686378
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)_IXa_I

674847
type: SpeciesReference
stoichiometry: 1.0
species: 686372

674835
type: SpeciesReference
stoichiometry: 1.0
species: 686318

686318
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)_IXa

COPASI44
type: Reaction
kinetic law: 674438
product: 674426
product: 674414
reactant: 674402
fast: false
reversible: false
name: IIa-V activation

674426
type: SpeciesReference
stoichiometry: 1.0
species: 686364

686364
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va(IIa)

674414
type: SpeciesReference
stoichiometry: 1.0
species: 686362

674402
type: SpeciesReference
stoichiometry: 1.0
species: 686368

686373
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: TF_VIIa_I

687303
type: Parameter
constant: true
value: 1.0
name: k25

687294
type: Parameter
constant: true
value: 0.1
name: k22

687339
type: Parameter
constant: true
value: 15.0
name: k37

COPASI39
type: Reaction
kinetic law: 674198
product: 674186
reactant: 674174
reactant: 674162
fast: false
reversible: true
name: mIIa-V binding

674186
type: SpeciesReference
stoichiometry: 1.0
species: 686363

686363
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: mIIa_V

674174
type: SpeciesReference
stoichiometry: 1.0
species: 686330

674162
type: SpeciesReference
stoichiometry: 1.0
species: 686359

COPASI19
type: Reaction
kinetic law: 673273
product: 673261
reactant: 673249
reactant: 673237
fast: false
reversible: true
name: VIIIa(Xa)-IXa binding

673261
type: SpeciesReference
stoichiometry: 1.0
species: 686318

673249
type: SpeciesReference
stoichiometry: 1.0
species: 686305

673237
type: SpeciesReference
stoichiometry: 1.0
species: 686315

686315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)

687288
type: Parameter
constant: true
value: 1.0
name: k20

686379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(IIa)_IXa_I

687333
type: Parameter
constant: true
value: 1.3
name: k35

COPASI25
type: Reaction
kinetic law: 673561
product: 673549
product: 673537
reactant: 673525
fast: false
reversible: false
name: VIII_IXa inactivation

673549
type: SpeciesReference
stoichiometry: 1.0
species: 686305

673537
type: SpeciesReference
stoichiometry: 1.0
species: 686325

686325
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIII*

673525
type: SpeciesReference
stoichiometry: 1.0
species: 686314

686314
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIII_IXa

COPASI35
type: Reaction
kinetic law: 674018
product: 674006
reactant: 673994
reactant: 673982
fast: false
reversible: true
name: Va_Xa-II binding

674006
type: SpeciesReference
stoichiometry: 1.0
species: 686357

686357
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa_II

673994
type: SpeciesReference
stoichiometry: 1.0
species: COPASI2

COPASI2
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 1400.0
initial amount: NaN
in compartment: 686298
name: II

673982
type: SpeciesReference
stoichiometry: 1.0
species: 686338

687249
type: Parameter
constant: true
value: 0.1
name: k7

687354
type: Parameter
constant: true
value: 0.1
name: k42

COPASI56
type: Reaction
kinetic law: 675015
product: 675003
reactant: 674991
reactant: 674979
fast: false
reversible: true
name: Va inhibition by Xa_I

675003
type: SpeciesReference
stoichiometry: 1.0
species: 686383

674991
type: SpeciesReference
stoichiometry: 1.0
species: 686382

674979
type: SpeciesReference
stoichiometry: 1.0
species: 686334

686334
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va

COPASI30
type: Reaction
kinetic law: 673777
product: 673765
reactant: 673753
reactant: 673741
fast: false
reversible: true
name: Xa-V binding

673765
type: SpeciesReference
stoichiometry: 1.0
species: 686333

686333
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Xa_V

673753
type: SpeciesReference
stoichiometry: 1.0
species: 686330

673741
type: SpeciesReference
stoichiometry: 1.0
species: 686310

COPASI12
type: Parameter
constant: true
value: 1000.0
name: Ki_Xa

COPASI21
type: Reaction
kinetic law: 673369
product: 673357
reactant: 673345
reactant: 673333
fast: false
reversible: true
name: VIIIa(Xa)_IXa-X binding

673357
type: SpeciesReference
stoichiometry: 1.0
species: 686323

673345
type: SpeciesReference
stoichiometry: 1.0
species: 686309

673333
type: SpeciesReference
stoichiometry: 1.0
species: 686318

687270
type: Parameter
constant: true
value: 29.0
name: k14

687315
type: Parameter
constant: true
value: 13.0
name: k29

686304
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: TF_VIIa_IX

COPASI51
type: Reaction
kinetic law: 674774
product: 674762
reactant: 674750
reactant: 674738
fast: false
reversible: true
name: VIIIa(Xa) inhibition by IXa_I

674762
type: SpeciesReference
stoichiometry: 1.0
species: 686378

674750
type: SpeciesReference
stoichiometry: 1.0
species: 686374

674738
type: SpeciesReference
stoichiometry: 1.0
species: 686315

687279
type: Parameter
constant: true
value: 2.2E-4
name: k17

687324
type: Parameter
constant: true
value: 15.0
name: k32

686387
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: Va_Xa_mIIa_I

COPASI9
type: Parameter
constant: true
value: 100.0
name: k49

687345
type: Parameter
constant: true
value: 0.1
name: k39

COPASI37
type: Reaction
kinetic law: 674102
product: 674090
reactant: 674078
fast: false
reversible: false
name: Va_Xa_II meizothrombin conversion

674090
type: SpeciesReference
stoichiometry: 1.0
species: 686358

674078
type: SpeciesReference
stoichiometry: 1.0
species: 686357

686300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 90.0
initial amount: NaN
in compartment: 686298
name: IX

COPASI58
type: Reaction
kinetic law: 675111
product: 675099
reactant: 675087
reactant: 675075
fast: false
reversible: true
name: mIIa inhibition

675099
type: SpeciesReference
stoichiometry: 1.0
species: 686384

686384
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: mIIa_I

675087
type: SpeciesReference
stoichiometry: 1.0
species: 686372

675075
type: SpeciesReference
stoichiometry: 1.0
species: 686359

COPASI5
type: Parameter
constant: true
value: 0.1
name: k45

687234
type: Parameter
constant: true
value: 2.2
name: k2

687306
type: Parameter
constant: true
value: 1.0
name: k26

COPASI42
type: Reaction
kinetic law: 674342
product: 674330
product: 674318
reactant: 674306
fast: false
reversible: false
name: mIIa-VIII activation

674330
type: SpeciesReference
stoichiometry: 1.0
species: 686319

674318
type: SpeciesReference
stoichiometry: 1.0
species: 686359

674306
type: SpeciesReference
stoichiometry: 1.0
species: 686367

COPASI33
type: Reaction
kinetic law: 673922
product: 673910
product: 673898
reactant: 673886
fast: false
reversible: false
name: Xa-VIII activation

673910
type: SpeciesReference
stoichiometry: 1.0
species: 686315

673898
type: SpeciesReference
stoichiometry: 1.0
species: 686310

673886
type: SpeciesReference
stoichiometry: 1.0
species: 686335

687255
type: Parameter
constant: true
value: 0.1
name: k9

COPASI10
type: Parameter
constant: true
value: 1000.0
name: Ki_VIIa

687300
type: Parameter
constant: true
value: 0.023
name: k24

687261
type: Parameter
constant: true
value: 0.1
name: k11

687357
type: Parameter
constant: true
value: 15.0
name: k43

686377
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIII_IXa_I

COPASI49
type: Reaction
kinetic law: 674678
product: 674666
reactant: 674654
reactant: 674642
fast: false
reversible: true
name: VIII inhibition by IXa_I

674666
type: SpeciesReference
stoichiometry: 1.0
species: 686377

674654
type: SpeciesReference
stoichiometry: 1.0
species: 686374

674642
type: SpeciesReference
stoichiometry: 1.0
species: 686313

COPASI29
type: Reaction
kinetic law: 673729
product: 673717
reactant: 673705
fast: false
reversible: false
name: VIIIa(IIa) inactivation

673717
type: SpeciesReference
stoichiometry: 1.0
species: 686329

673705
type: SpeciesReference
stoichiometry: 1.0
species: 686319

COPASI14
type: Reaction
kinetic law: 673032
product: 673020
reactant: 673008
reactant: 672996
fast: false
reversible: true
name: TF_VIIa-IX binding

673020
type: SpeciesReference
stoichiometry: 1.0
species: 686304

673008
type: SpeciesReference
stoichiometry: 1.0
species: 686300

672996
type: SpeciesReference
stoichiometry: 1.0
species: 686303

COPASI24
type: Reaction
kinetic law: 673513
product: 673501
product: 673489
reactant: 673477
fast: false
reversible: false
name: VIIIa(IIa)_IXa-X activation

673501
type: SpeciesReference
stoichiometry: 1.0
species: 686310

673489
type: SpeciesReference
stoichiometry: 1.0
species: 686320

673477
type: SpeciesReference
stoichiometry: 1.0
species: 686324

COPASI7
type: Parameter
constant: true
value: 100.0
name: k47

687273
type: Parameter
constant: true
value: 2.1E-4
name: k15

687246
type: Parameter
constant: true
value: 1.4
name: k6

COPASI45
type: Reaction
kinetic law: 674486
product: 674474
reactant: 674462
reactant: 674450
fast: false
reversible: true
name: IIa-VIII binding

674474
type: SpeciesReference
stoichiometry: 1.0
species: 686369

674462
type: SpeciesReference
stoichiometry: 1.0
species: 686313

674450
type: SpeciesReference
stoichiometry: 1.0
species: 686362

687471
type: Parameter
constant: true
value: 1400.0
name: totalThrombin

687267
type: Parameter
constant: true
value: 17.0
name: k13

COPASI40
type: Reaction
kinetic law: 674246
product: 674234
product: 674222
reactant: 674210
fast: false
reversible: false
name: mIIa-V activation

674234
type: SpeciesReference
stoichiometry: 1.0
species: 686364

674222
type: SpeciesReference
stoichiometry: 1.0
species: 686359

674210
type: SpeciesReference
stoichiometry: 1.0
species: 686363

687312
type: Parameter
constant: true
value: 46.0
name: k28

COPASI61
type: Reaction
kinetic law: 675256
product: 675244
reactant: 675232
reactant: 675220
fast: false
reversible: true
name: IIa inhibition

675244
type: SpeciesReference
stoichiometry: 1.0
species: COPASI3

COPASI3
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: IIa_I

675232
type: SpeciesReference
stoichiometry: 1.0
species: 686372

675220
type: SpeciesReference
stoichiometry: 1.0
species: 686362

COPASI26
type: Reaction
kinetic law: 673609
product: 673597
product: 673585
reactant: 673573
fast: false
reversible: false
name: VIIIa(Xa)_IXa inactivation

673597
type: SpeciesReference
stoichiometry: 1.0
species: 686305

673585
type: SpeciesReference
stoichiometry: 1.0
species: 686328

686328
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: 0.0
initial amount: NaN
in compartment: 686298
name: VIIIa(Xa)*

673573
type: SpeciesReference
stoichiometry: 1.0
species: 686318

672912
type: SBMLUnitsDef
unit: 672924
name: substance

672924
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

COPASI16
type: Reaction
kinetic law: 673128
product: 673116
reactant: 673104
reactant: 673092
fast: false
reversible: true
name: TF_VIIa-X binding

673116
type: SpeciesReference
stoichiometry: 1.0
species: 686308

673104
type: SpeciesReference
stoichiometry: 1.0
species: 686309

673092
type: SpeciesReference
stoichiometry: 1.0
species: 686303

687285
type: Parameter
constant: true
value: 0.1
name: k19

COPASI54
type: Reaction
kinetic law: 674919
product: 674907
reactant: 674895
reactant: 674883
fast: false
reversible: true
name: VIIIa(IIa)_IXa inhibition

674907
type: SpeciesReference
stoichiometry: 1.0
species: 686379

674895
type: SpeciesReference
stoichiometry: 1.0
species: 686372

674883
type: SpeciesReference
stoichiometry: 1.0
species: 686320

COPASI47
type: Reaction
kinetic law: 674582
product: 674570
reactant: 674558
reactant: 674546
fast: false
reversible: true
name: TF_VIIa inhibition

674570
type: SpeciesReference
stoichiometry: 1.0
species: 686373

674558
type: SpeciesReference
stoichiometry: 1.0
species: 686372

674546
type: SpeciesReference
stoichiometry: 1.0
species: 686303

687258
type: Parameter
constant: true
value: 0.17
name: k10

687330
type: Parameter
constant: true
value: 7.2
name: k34

COPASI57
type: Reaction
kinetic law: 675063
product: 675051
reactant: 675039
reactant: 675027
fast: false
reversible: true
name: Va_Xa inhibition

675051
type: SpeciesReference
stoichiometry: 1.0
species: 686383

675039
type: SpeciesReference
stoichiometry: 1.0
species: 686372

675027
type: SpeciesReference
stoichiometry: 1.0
species: 686338

COPASI31
type: Reaction
kinetic law: 673826
product: 673814
product: 673801
reactant: 673789
fast: false
reversible: false
name: Xa-V activation

673814
type: SpeciesReference
stoichiometry: 1.0
species: 686334

673801
type: SpeciesReference
stoichiometry: 1.0
species: 686310

673789
type: SpeciesReference
stoichiometry: 1.0
species: 686333

COPASI13
type: Parameter
constant: true
value: 1000.0
name: Ki_IIa

COPASI22
type: Reaction
kinetic law: 673417
product: 673405
product: 673393
reactant: 673381
fast: false
reversible: false
name: VIIIa(Xa)_IXa-X activation

673405
type: SpeciesReference
stoichiometry: 1.0
species: 686310

673393
type: SpeciesReference
stoichiometry: 1.0
species: 686318

673381
type: SpeciesReference
stoichiometry: 1.0
species: 686323

687351
type: Parameter
constant: true
value: 0.26
name: k41

COPASI52
type: Reaction
kinetic law: 674823
product: 674811
reactant: 674799
reactant: 674786
fast: false
reversible: true
name: VIIIa(IIa) inhibition by IXa_I

674811
type: SpeciesReference
stoichiometry: 1.0
species: 686379

674799
type: SpeciesReference
stoichiometry: 1.0
species: 686374

674786
type: SpeciesReference
stoichiometry: 1.0
species: 686319

COPASI20
type: Reaction
kinetic law: 673321
product: 673309
reactant: 673297
reactant: 673285
fast: false
reversible: true
name: VIIIa(IIa)-IXa binding

673309
type: SpeciesReference
stoichiometry: 1.0
species: 686320

673297
type: SpeciesReference
stoichiometry: 1.0
species: 686305

673285
type: SpeciesReference
stoichiometry: 1.0
species: 686319

COPASI6
type: Parameter
constant: true
value: 100.0
name: k46

687240
type: Parameter
constant: true
value: 0.1
name: k4

687276
type: Parameter
constant: true
value: 8.0E-5
name: k16

COPASI38
type: Reaction
kinetic law: 674150
product: 674138
product: 674126
reactant: 674114
fast: false
reversible: false
name: Va_Xa_mIIa thrombin conversion

674138
type: SpeciesReference
stoichiometry: 1.0
species: 686362

674126
type: SpeciesReference
stoichiometry: 1.0
species: 686338

674114
type: SpeciesReference
stoichiometry: 1.0
species: 686358

COPASI18
type: Reaction
kinetic law: 673225
product: 673213
reactant: 673201
reactant: 673188
fast: false
reversible: true
name: VIII-IXa binding

673213
type: SpeciesReference
stoichiometry: 1.0
species: 686314

673201
type: SpeciesReference
stoichiometry: 1.0
species: 686305

673188
type: SpeciesReference
stoichiometry: 1.0
species: 686313

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

COPASI28
type: Reaction
kinetic law: 673693
product: 673681
reactant: 673669
fast: false
reversible: false
name: VIIIa(Xa) inactivation

673681
type: SpeciesReference
stoichiometry: 1.0
species: 686328

673669
type: SpeciesReference
stoichiometry: 1.0
species: 686315

687297
type: Parameter
constant: true
value: 2.1
name: k23

COPASI59
type: Reaction
kinetic law: 675160
product: 675148
reactant: 675135
reactant: 675124
fast: false
reversible: true
name: Va_Xa inhibition by mIIa_I

675148
type: SpeciesReference
stoichiometry: 1.0
species: 686387

675135
type: SpeciesReference
stoichiometry: 1.0
species: 686384

675124
type: SpeciesReference
stoichiometry: 1.0
species: 686338

687342
type: Parameter
constant: true
value: 0.9
name: k38

COPASI34
type: Reaction
kinetic law: 673970
product: 673958
reactant: 673946
reactant: 673934
fast: false
reversible: true
name: Va-Xa binding

673958
type: SpeciesReference
stoichiometry: 1.0
species: 686338

673946
type: SpeciesReference
stoichiometry: 1.0
species: 686310

673934
type: SpeciesReference
stoichiometry: 1.0
species: 686334

687318
type: Parameter
constant: true
value: 0.1
name: k30

687470
type: Parameter
constant: true
value: 0.0
name: time_80%Thrombin

COPASI11
type: Parameter
constant: true
value: 1000.0
name: Ki_IXa

687231
type: Parameter
constant: true
value: 0.1
name: k1

COPASI50
type: Reaction
kinetic law: 674726
product: 674714
reactant: 674702
reactant: 674690
fast: false
reversible: true
name: VIII_IXa inhibition

674714
type: SpeciesReference
stoichiometry: 1.0
species: 686377

674702
type: SpeciesReference
stoichiometry: 1.0
species: 686372

674690
type: SpeciesReference
stoichiometry: 1.0
species: 686314

687252
type: Parameter
constant: true
value: 0.4
name: k8

COPASI60
type: Reaction
kinetic law: 675208
product: 675196
reactant: 675184
reactant: 675172
fast: false
reversible: true
name: Va_Xa_mIIa inhibition

675196
type: SpeciesReference
stoichiometry: 1.0
species: 686387

675184
type: SpeciesReference
stoichiometry: 1.0
species: 686372

675172
type: SpeciesReference
stoichiometry: 1.0
species: 686358

COPASI15
type: Reaction
kinetic law: 673080
product: 673068
product: 673056
reactant: 673044
fast: false
reversible: false
name: TF_VIIa-IX activation

673068
type: SpeciesReference
stoichiometry: 1.0
species: 686305

673056
type: SpeciesReference
stoichiometry: 1.0
species: 686303

673044
type: SpeciesReference
stoichiometry: 1.0
species: 686304

687291
type: Parameter
constant: true
value: 0.043
name: k21

687336
type: Parameter
constant: true
value: 0.1
name: k36

W3 CDTF: Thu Sep 15 14:32:24 BST 2011

W3 CDTF: Thu Sep 15 14:32:24 BST 2011

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert

W3 CDTF: Thu Sep 15 14:32:24 BST 2011

W3 CDTF: Thu Sep 15 14:28:14 BST 2011

ORG:
  orgname: EBI
n:
  given: Michael
  family: Schubert