MODEL1107050000
type: SBMLModel
reaction: meta Regulation of CASP3 on GORASP1 using Proteolytic Processing
reaction: meta containment reaction apoptosome
reaction: meta Regulation of MYL12A on myosin II using Other
reaction: meta Regulation of BBC3 on BCL2L1 using Physical Interaction
species: meta DNA repair
species: meta NonActive EIF2S2
species: meta Active BAD
reaction: meta Regulation of BCL2L11 on BCL2 using Physical Interaction
species: meta NonActive CASP8
species: meta Active EIF2S3
reaction: meta Regulation of IKK on NFKBIE using Phosphorylation
reaction: meta Regulation of BIRC3 on CASP9 using Physical Interaction
reaction: meta Regulation of CASP3 on CASP9 using Proteolytic Processing
reaction: meta Regulation of NAIP on CASP3 using Physical Interaction
species: meta Active BCL2A1
species: meta Active BMF
reaction: meta Regulation of DAPK1 on MYL7 using Phosphorylation
reaction: meta Regulation of MYL7 on myosin II using Other
species: meta Active TNF
reaction: meta Regulation of CASP9 on BIRC6 using Proteolytic Processing
species: meta Active NFKBIA
species: meta NonActive BIRC3
reaction: meta Regulation of EIF4G2 on APAF1 using Translational Regulation
reaction: meta Regulation of DAPK1 on MYL12A using Phosphorylation
reaction: meta Regulation of CASP3 on DFFA using Proteolytic Processing
reaction: meta Regulation of PMAIP1 on MCL1 using Physical Interaction
reaction: meta Regulation of BAK1 on ENDOG using Indirect
reaction: meta Regulation of GSN on cytosk stability using Other
species: meta NonActive EIF4EBP1
reaction: meta Regulation of CASP3 on GSN using Proteolytic Processing
reaction: meta Regulation of TNFRSF10A on RIPK1 using Physical Interaction
species: meta Active EIF4G2
species: meta Active RPS6KA1
reaction: meta Regulation of BAX on ENDOG using Indirect
reaction: meta Regulation of APAF1 on CASP9 using Physical Interaction
reaction: meta Regulation of ROCK1 on MYL12B using Phosphorylation
species: meta NonActive FAS
species: meta NonActive CTNNB1
reaction: meta Regulation of CASP8 on CASP3 using Proteolytic Processing
species: meta Active BNIP3
reaction: meta containment reaction IKK
species: meta Active BAX
reaction: meta Regulation of FADD on RIPK1 using Physical Interaction
species: meta NonActive TNFRSF1A
reaction: meta Regulation of MYL12B on myosin II using Other
species: meta Active GSN
species: meta Active CASP3
reaction: meta Regulation of TRADD on FADD using Physical Interaction
notes: This model is from the article: Systems biology analysis of programmed cell death Shani Bialik, Einat Zalckvar, Yaara Ber, Assaf D. Rubinstein, Adi Kimchi Trends in Biochemical Sciences Volume 35, Issue 10, 556-564, 27 May 2010 20537543 , Abstract: Systems biology, a combined computational and experimental approach to analyzing complex biological systems, has recently been applied to understanding the pathways that regulate programmed cell death. This approach has become especially crucial because recent advances have resulted in an expanded view of the network, to include not just a single death module (apoptosis) but multiple death programs, including programmed necrosis and autophagic cell death. Current research directions in the systems biology field range from quantitative analysis of subprocesses of individual death pathways to the study of interconnectivity among the various death modules of the larger network. These initial studies have provided great advances in our understanding of programmed cell death and have important clinical implications for drug target research. Brief Note about the model: This model is an export of 26 SPIKE Apoptosis Networks to SBML format. This is a pathway model (not quantitative model) of Apoptosis. Apoptosis, or type I cell death, is a form of programmed cell death characterized by fragmentation of the cytoplasm and nucleus, chromatin condensation and fragmentation, cytoskeletal collapse, membrane blebbing, and finally, disintegration of the cell into apoptotic bodies, which are engulfed by adjacent cells, thereby avoiding an inflammatory response. It serves to model tissues during embryonic development, to regulate cell number by eliminating excess cells, and to remove damaged, mutated or infected cells. Defective or excessive apoptosis can lead to cancer or autoimmune and degenerative diseases, respectively. Apoptosis is executed by a family of cysteine proteases, the caspases, which function in a proteolytic cascade that i…
species: meta Active DYNLL1
species: meta Active CASP6
reaction: meta Regulation of XIAP on CASP9 using Physical Interaction
species: meta NonActive DAPK3
species: meta cytosk stability
reaction: meta Regulation of BAK1 on BAK1 using Physical Interaction
reaction: meta Regulation of BCL2L2 on BAX using Physical Interaction
species: meta NonActive BIRC5
reaction: meta Regulation of DAPK3 on MYL12A using Phosphorylation
reaction: meta Regulation of RPS6KA3 on BAD using Phosphorylation
species: meta Active FAS
species: meta membrane blebbing
reaction: meta containment reaction DISC
reaction: meta Regulation of CASP3 on EIF4G3 using Proteolytic Processing
reaction: meta Regulation of CFLAR on FADD using Physical Interaction
species: meta chromatin condensation
species: meta NonActive BAX
reaction: meta Regulation of DIABLO on BIRC2 using Physical Interaction
species: meta NonActive GOLGA3
species: meta Active BAK1
reaction: meta Regulation of LRDD on CASP2 using Physical Interaction
reaction: meta Regulation of PPP1CA on BAD using Dephosphorylation
species: meta Active EIF4G3
reaction: meta Regulation of FASLG on FAS using Physical Interaction
reaction: meta Regulation of CASP3 on EIF3J using Proteolytic Processing
reaction: meta Regulation of FADD on CASP8 using Physical Interaction
reaction: meta Regulation of TNFRSF10B on RIPK1 using Physical Interaction
reaction: meta Regulation of BIRC2 on CASP7 using Physical Interaction
reaction: meta Regulation of CASP2 on GOLGA3 using Proteolytic Processing
reaction: meta Regulation of DAPK3 on MYL10 using Phosphorylation

meta Regulation of CASP3 on GORASP1 using Proteolytic Processing
type: Reaction
modifier: 328994
product: 328982
reactant: 328970
is described by: http://identifiers.org/pubmed/11815631
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_GORASP1_using_Proteolytic Processing

meta Active CASP3
type: Species
is encoded by: http://identifiers.org/ncbigene/836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP3

meta SPIKE cell
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: SPIKE_cell

328982
type: SpeciesReference
stoichiometry: 1.0
species: meta Active GORASP1

meta Active GORASP1
type: Species
is encoded by: http://identifiers.org/ncbigene/64689
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_GORASP1

328970
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive GORASP1

meta NonActive GORASP1
type: Species
is encoded by: http://identifiers.org/ncbigene/64689
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_GORASP1

meta containment reaction apoptosome
type: Reaction
product: 327710
reactant: 327698
reactant: 327686
reactant: 327674
fast: false
reversible: true
name: APAF1-CASP9 precursor_containment

327710
type: SpeciesReference
stoichiometry: 1.0
species: meta Active apoptosome

meta Active apoptosome
type: Species
has part: http://identifiers.org/ncbigene/317
name: Active_APAF1-CASP9 precursor
has part: http://identifiers.org/ncbigene/54205
boundary condition: false
has only substance units: false
initial amount: NaN
has part: http://identifiers.org/ncbigene/842
initial concentration: NaN
constant: false
in compartment: meta SPIKE cell

327698
type: SpeciesReference
stoichiometry: 1.0
species: meta Active APAF1

meta Active APAF1
type: Species
is encoded by: http://identifiers.org/ncbigene/317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_APAF1

327686
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP9

meta Active CASP9
type: Species
is encoded by: http://identifiers.org/ncbigene/842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP9

327674
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CYCS

meta Active CYCS
type: Species
is encoded by: http://identifiers.org/ncbigene/54205
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CYCS

meta Regulation of MYL12A on myosin II using Other
type: Reaction
modifier: 334371
product: 334359
reactant: 334347
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL12A_on_myosin II_using_Other

meta Active MYL12A
type: Species
is encoded by: http://identifiers.org/ncbigene/10627
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL12A

334359
type: SpeciesReference
stoichiometry: 1.0
species: meta Active myosin II

meta Active myosin II
type: Species
has part: http://identifiers.org/ncbigene/000019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_myosin II

334347
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive myosin II

meta NonActive myosin II
type: Species
has part: http://identifiers.org/ncbigene/000019
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_myosin II

meta Regulation of BBC3 on BCL2L1 using Physical Interaction
type: Reaction
modifier: 331502
product: 331490
reactant: 331477
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_BCL2L1_using_Physical Interaction

meta Active BBC3
type: Species
is encoded by: http://identifiers.org/ncbigene/27113
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BBC3

331490
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2L1

meta Active BCL2L1
type: Species
is encoded by: http://identifiers.org/ncbigene/598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2L1

331477
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2L1

meta NonActive BCL2L1
type: Species
is encoded by: http://identifiers.org/ncbigene/598
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BCL2L1

meta DNA repair
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: DNA repair

meta NonActive EIF2S2
type: Species
is encoded by: http://identifiers.org/ncbigene/8894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF2S2

meta Active BAD
type: Species
is encoded by: http://identifiers.org/ncbigene/572
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BAD

meta Regulation of BCL2L11 on BCL2 using Physical Interaction
type: Reaction
modifier: 330992
product: 330980
reactant: 330967
is described by: http://identifiers.org/pubmed/9731710
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BCL2L11_on_BCL2_using_Physical Interaction

meta Active BCL2L11
type: Species
is encoded by: http://identifiers.org/ncbigene/10018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2L11

330980
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2

meta Active BCL2
type: Species
is encoded by: http://identifiers.org/ncbigene/596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2

330967
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2

meta NonActive BCL2
type: Species
is encoded by: http://identifiers.org/ncbigene/596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BCL2

meta NonActive CASP8
type: Species
is encoded by: http://identifiers.org/ncbigene/841
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP8

meta Active EIF2S3
type: Species
is encoded by: http://identifiers.org/ncbigene/1968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF2S3

meta Regulation of IKK on NFKBIE using Phosphorylation
type: Reaction
modifier: 335180
product: 335168
reactant: 335156
is described by: http://identifiers.org/pubmed/10644043
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_IKK_on_NFKBIE_using_Phosphorylation

meta Active IKK
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_IKK complex

335168
type: SpeciesReference
stoichiometry: 1.0
species: meta Active NFKBIE

meta Active NFKBIE
type: Species
is encoded by: http://identifiers.org/ncbigene/4794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_NFKBIE

335156
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive NFKBIE

meta NonActive NFKBIE
type: Species
is encoded by: http://identifiers.org/ncbigene/4794
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_NFKBIE

meta Regulation of BIRC3 on CASP9 using Physical Interaction
type: Reaction
reversible: false
is: SBO:0000181
is described by: http://identifiers.org/pubmed/9990849
modifier: 329212
product: 329199
is described by: http://identifiers.org/pubmed/9545235
name: Regulation_of_BIRC3_on_CASP9_using_Physical Interaction
fast: false
reactant: 329187

meta Active BIRC3
type: Species
is encoded by: http://identifiers.org/ncbigene/330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC3

329199
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP9

329187
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP9

meta NonActive CASP9
type: Species
is encoded by: http://identifiers.org/ncbigene/842
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP9

meta Regulation of CASP3 on CASP9 using Proteolytic Processing
type: Reaction
modifier: 333971
product: 333959
reactant: 333947
is described by: http://identifiers.org/pubmed/8900201
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP9_using_Proteolytic Processing

333959
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP9

333947
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP9

meta Regulation of NAIP on CASP3 using Physical Interaction
type: Reaction
modifier: 334225
product: 334212
reactant: 334200
is described by: http://identifiers.org/pubmed/9990849
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_NAIP_on_CASP3_using_Physical Interaction

meta Active NAIP
type: Species
is encoded by: http://identifiers.org/ncbigene/4671
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_NAIP

334212
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP3

334200
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP3

meta NonActive CASP3
type: Species
is encoded by: http://identifiers.org/ncbigene/836
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP3

meta Active BCL2A1
type: Species
is encoded by: http://identifiers.org/ncbigene/597
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2A1

meta Active BMF
type: Species
is encoded by: http://identifiers.org/ncbigene/90427
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BMF

meta Regulation of DAPK1 on MYL7 using Phosphorylation
type: Reaction
reversible: false
reactant: 334867
modifier: 334891
fast: false
is described by: http://identifiers.org/pubmed/15002035
is described by: http://identifiers.org/pubmed/14600263
is: SBO:0000216
name: Regulation_of_DAPK1_on_MYL7_using_Phosphorylation
is described by: http://identifiers.org/pubmed/11485996
product: 334879

334867
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL7

meta NonActive MYL7
type: Species
is encoded by: http://identifiers.org/ncbigene/58498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MYL7

meta Active DAPK1
type: Species
is encoded by: http://identifiers.org/ncbigene/1612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DAPK1

334879
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL7

meta Active MYL7
type: Species
is encoded by: http://identifiers.org/ncbigene/58498
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL7

meta Regulation of MYL7 on myosin II using Other
type: Reaction
modifier: 334521
product: 334508
reactant: 334495
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL7_on_myosin II_using_Other

334508
type: SpeciesReference
stoichiometry: 1.0
species: meta Active myosin II

334495
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive myosin II

meta Active TNF
type: Species
is encoded by: http://identifiers.org/ncbigene/7124
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNF

meta Regulation of CASP9 on BIRC6 using Proteolytic Processing
type: Reaction
modifier: 329429
product: 329417
reactant: 329405
is described by: http://identifiers.org/pubmed/15507451
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP9_on_BIRC6_using_Proteolytic Processing

329417
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BIRC6

meta Active BIRC6
type: Species
is encoded by: http://identifiers.org/ncbigene/57448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC6

329405
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC6

meta NonActive BIRC6
type: Species
is encoded by: http://identifiers.org/ncbigene/57448
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BIRC6

meta Active NFKBIA
type: Species
is encoded by: http://identifiers.org/ncbigene/4792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_NFKBIA

meta NonActive BIRC3
type: Species
is encoded by: http://identifiers.org/ncbigene/330
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BIRC3

meta Regulation of EIF4G2 on APAF1 using Translational Regulation
type: Reaction
modifier: 335360
product: 335348
reactant: 335336
is described by: http://identifiers.org/pubmed/11943866
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_APAF1_using_Translational Regulation

meta Active EIF4G2
type: Species
is encoded by: http://identifiers.org/ncbigene/1982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4G2

335348
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive APAF1

meta NonActive APAF1
type: Species
is encoded by: http://identifiers.org/ncbigene/317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_APAF1

335336
type: SpeciesReference
stoichiometry: 1.0
species: meta mRNA APAF1

meta mRNA APAF1
type: Species
is encoded by: http://identifiers.org/ncbigene/317
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_APAF1

meta Regulation of DAPK1 on MYL12A using Phosphorylation
type: Reaction
fast: false
modifier: 334747
reversible: false
is described by: http://identifiers.org/pubmed/11485996
is described by: http://identifiers.org/pubmed/15002035
product: 334734
name: Regulation_of_DAPK1_on_MYL12A_using_Phosphorylation
reactant: 334722
is: SBO:0000216
is described by: http://identifiers.org/pubmed/14600263

334734
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL12A

334722
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL12A

meta NonActive MYL12A
type: Species
is encoded by: http://identifiers.org/ncbigene/10627
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MYL12A

meta Regulation of CASP3 on DFFA using Proteolytic Processing
type: Reaction
fast: false
modifier: 329612
name: Regulation_of_CASP3_on_DFFA_using_Proteolytic Processing
is described by: http://identifiers.org/pubmed/9422506
is: SBO:0000179
reactant: 329587
product: 329600
is described by: http://identifiers.org/pubmed/9108473
reversible: false

329587
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive DFFA

meta NonActive DFFA
type: Species
is encoded by: http://identifiers.org/ncbigene/1676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DFFA

329600
type: SpeciesReference
stoichiometry: 1.0
species: meta Active DFFA

meta Active DFFA
type: Species
is encoded by: http://identifiers.org/ncbigene/1676
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DFFA

meta Regulation of PMAIP1 on MCL1 using Physical Interaction
type: Reaction
modifier: 329976
product: 329964
reactant: 329952
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_PMAIP1_on_MCL1_using_Physical Interaction

meta Active PMAIP1
type: Species
is encoded by: http://identifiers.org/ncbigene/5366
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_PMAIP1

329964
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MCL1

meta Active MCL1
type: Species
is encoded by: http://identifiers.org/ncbigene/4170
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MCL1

329952
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MCL1

meta NonActive MCL1
type: Species
is encoded by: http://identifiers.org/ncbigene/4170
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MCL1

meta Regulation of BAK1 on ENDOG using Indirect
type: Reaction
modifier: 330557
product: 330545
reactant: 330533
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAK1_on_ENDOG_using_Indirect

meta Active BAK1
type: Species
is encoded by: http://identifiers.org/ncbigene/578
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BAK1

330545
type: SpeciesReference
stoichiometry: 1.0
species: meta Active ENDOG

meta Active ENDOG
type: Species
is encoded by: http://identifiers.org/ncbigene/2021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_ENDOG

330533
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive ENDOG

meta NonActive ENDOG
type: Species
is encoded by: http://identifiers.org/ncbigene/2021
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_ENDOG

meta Regulation of GSN on cytosk stability using Other
type: Reaction
modifier: 332152
product: 332140
reactant: 332128
is described by: http://identifiers.org/pubmed/10047530
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_GSN_on_cytosk. stability_using_Other

meta Active GSN
type: Species
is encoded by: http://identifiers.org/ncbigene/2934
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_GSN

332140
type: SpeciesReference
stoichiometry: 1.0
species: meta cytosk stability

meta cytosk stability
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: cytosk. stability

332128
type: SpeciesReference
stoichiometry: 1.0
species: meta cytosk stability

meta NonActive EIF4EBP1
type: Species
is encoded by: http://identifiers.org/ncbigene/1978
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4EBP1

meta Regulation of CASP3 on GSN using Proteolytic Processing
type: Reaction
reactant: 332964
is: SBO:0000179
name: Regulation_of_CASP3_on_GSN_using_Proteolytic Processing
modifier: 332988
is described by: http://identifiers.org/pubmed/9323209
product: 332976
is described by: http://identifiers.org/pubmed/9930654
fast: false
reversible: false

332964
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive GSN

meta NonActive GSN
type: Species
is encoded by: http://identifiers.org/ncbigene/2934
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_GSN

332976
type: SpeciesReference
stoichiometry: 1.0
species: meta Active GSN

meta Regulation of TNFRSF10A on RIPK1 using Physical Interaction
type: Reaction
modifier: 328557
product: 328544
reactant: 328532
is described by: http://identifiers.org/pubmed/9430227
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFRSF10A_on_RIPK1_using_Physical Interaction

meta Active TNFRSF10A
type: Species
is encoded by: http://identifiers.org/ncbigene/8797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNFRSF10A

328544
type: SpeciesReference
stoichiometry: 1.0
species: meta Active RIPK1

meta Active RIPK1
type: Species
is encoded by: http://identifiers.org/ncbigene/8737
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_RIPK1

328532
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive RIPK1

meta NonActive RIPK1
type: Species
is encoded by: http://identifiers.org/ncbigene/8737
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_RIPK1

meta Active RPS6KA1
type: Species
is encoded by: http://identifiers.org/ncbigene/6195
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_RPS6KA1

meta Regulation of BAX on ENDOG using Indirect
type: Reaction
modifier: 330411
product: 330399
reactant: 330387
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAX_on_ENDOG_using_Indirect

meta Active BAX
type: Species
is encoded by: http://identifiers.org/ncbigene/581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BAX

330399
type: SpeciesReference
stoichiometry: 1.0
species: meta Active ENDOG

330387
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive ENDOG

meta Regulation of APAF1 on CASP9 using Physical Interaction
type: Reaction
product: 332540
is described by: http://identifiers.org/pubmed/9922454
is: SBO:0000181
is described by: http://identifiers.org/pubmed/9488720
name: Regulation_of_APAF1_on_CASP9_using_Physical Interaction
fast: false
reactant: 332527
modifier: 332552
reversible: false

332540
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP9

332527
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP9

meta Regulation of ROCK1 on MYL12B using Phosphorylation
type: Reaction
is: SBO:0000216
name: Regulation_of_ROCK1_on_MYL12B_using_Phosphorylation
is described by: http://identifiers.org/pubmed/11283607
is described by: http://identifiers.org/pubmed/8702756
reversible: false
product: 335023
reactant: 335011
modifier: 335035
fast: false

335023
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL12B

meta Active MYL12B
type: Species
is encoded by: http://identifiers.org/ncbigene/103910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL12B

335011
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL12B

meta NonActive MYL12B
type: Species
is encoded by: http://identifiers.org/ncbigene/103910
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_MYL12B

meta Active ROCK1
type: Species
is encoded by: http://identifiers.org/ncbigene/6093
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_ROCK1

meta NonActive FAS
type: Species
is encoded by: http://identifiers.org/ncbigene/355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_FAS

meta NonActive CTNNB1
type: Species
is encoded by: http://identifiers.org/ncbigene/1499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CTNNB1

meta Regulation of CASP8 on CASP3 using Proteolytic Processing
type: Reaction
is: SBO:0000179
modifier: 332625
is described by: http://identifiers.org/pubmed/9765224
product: 332612
fast: false
reactant: 332600
is described by: http://identifiers.org/pubmed/11437602
name: Regulation_of_CASP8_on_CASP3_using_Proteolytic Processing
reversible: false

meta Active CASP8
type: Species
is encoded by: http://identifiers.org/ncbigene/841
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP8

332612
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP3

332600
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP3

meta Active BNIP3
type: Species
is encoded by: http://identifiers.org/ncbigene/664
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BNIP3

meta containment reaction IKK
type: Reaction
product: 327662
fast: false
reversible: true
name: IKK complex_containment

327662
type: SpeciesReference
stoichiometry: 1.0
species: meta Active IKK

meta Regulation of FADD on RIPK1 using Physical Interaction
type: Reaction
modifier: 327926
product: 327914
reactant: 327902
is described by: http://identifiers.org/pubmed/18485876
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_FADD_on_RIPK1_using_Physical Interaction

meta Active FADD
type: Species
is encoded by: http://identifiers.org/ncbigene/8772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_FADD

327914
type: SpeciesReference
stoichiometry: 1.0
species: meta Active RIPK1

327902
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive RIPK1

meta NonActive TNFRSF1A
type: Species
is encoded by: http://identifiers.org/ncbigene/7132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TNFRSF1A

meta Regulation of MYL12B on myosin II using Other
type: Reaction
modifier: 334481
product: 334468
reactant: 334455
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL12B_on_myosin II_using_Other

334468
type: SpeciesReference
stoichiometry: 1.0
species: meta Active myosin II

334455
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive myosin II

meta Regulation of TRADD on FADD using Physical Interaction
type: Reaction
modifier: 330593
product: 330581
reactant: 330569
is described by: http://identifiers.org/pubmed/8565075
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TRADD_on_FADD_using_Physical Interaction

meta Active TRADD
type: Species
is encoded by: http://identifiers.org/ncbigene/8717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TRADD

330581
type: SpeciesReference
stoichiometry: 1.0
species: meta Active FADD

330569
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive FADD

meta NonActive FADD
type: Species
is encoded by: http://identifiers.org/ncbigene/8772
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_FADD

meta Active DYNLL1
type: Species
is encoded by: http://identifiers.org/ncbigene/8655
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DYNLL1

meta Active CASP6
type: Species
is encoded by: http://identifiers.org/ncbigene/839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP6

meta Regulation of XIAP on CASP9 using Physical Interaction
type: Reaction
name: Regulation_of_XIAP_on_CASP9_using_Physical Interaction
modifier: 328849
fast: false
is described by: http://identifiers.org/pubmed/11927604
reactant: 328824
product: 328837
is described by: http://identifiers.org/pubmed/11390657
is described by: http://identifiers.org/pubmed/12042762
is: SBO:0000181
reversible: false

meta Active XIAP
type: Species
is encoded by: http://identifiers.org/ncbigene/331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_XIAP

328824
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP9

328837
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP9

meta NonActive DAPK3
type: Species
is encoded by: http://identifiers.org/ncbigene/1613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DAPK3

meta Regulation of BAK1 on BAK1 using Physical Interaction
type: Reaction
modifier: 329685
product: 329673
reactant: 329661
is described by: http://identifiers.org/pubmed/17157251
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BAK1_on_BAK1_using_Physical Interaction

329673
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAK1

329661
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAK1

meta NonActive BAK1
type: Species
is encoded by: http://identifiers.org/ncbigene/578
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BAK1

meta Regulation of BCL2L2 on BAX using Physical Interaction
type: Reaction
modifier: 329795
product: 329783
reactant: 329771
is described by: http://identifiers.org/pubmed/18178565
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BCL2L2_on_BAX_using_Physical Interaction

meta Active BCL2L2
type: Species
is encoded by: http://identifiers.org/ncbigene/599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2L2

329783
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAX

329771
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAX

meta NonActive BAX
type: Species
is encoded by: http://identifiers.org/ncbigene/581
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BAX

meta NonActive BIRC5
type: Species
is encoded by: http://identifiers.org/ncbigene/332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BIRC5

meta Regulation of DAPK3 on MYL12A using Phosphorylation
type: Reaction
product: 334548
is: SBO:0000216
is described by: http://identifiers.org/pubmed/11781833
reversible: false
fast: false
modifier: 334561
reactant: 334534
name: Regulation_of_DAPK3_on_MYL12A_using_Phosphorylation
is described by: http://identifiers.org/pubmed/10356987
is described by: http://identifiers.org/pubmed/15096528

334548
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL12A

meta Active DAPK3
type: Species
is encoded by: http://identifiers.org/ncbigene/1613
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DAPK3

334534
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL12A

meta Regulation of RPS6KA3 on BAD using Phosphorylation
type: Reaction
fast: false
name: Regulation_of_RPS6KA3_on_BAD_using_Phosphorylation
is: SBO:0000216
is described by: http://identifiers.org/pubmed/10976111
is described by: http://identifiers.org/pubmed/11983683
reversible: false
product: 333669
is described by: http://identifiers.org/pubmed/10558990
reactant: 333657
modifier: 333681

333669
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAD

333657
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAD

meta NonActive BAD
type: Species
is encoded by: http://identifiers.org/ncbigene/572
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BAD

meta Active RPS6KA3
type: Species
is encoded by: http://identifiers.org/ncbigene/6197
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_RPS6KA3

meta Active FAS
type: Species
is encoded by: http://identifiers.org/ncbigene/355
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_FAS

meta membrane blebbing
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: membrane blebbing

meta containment reaction DISC
type: Reaction
product: 327650
reactant: 327637
reactant: 327625
fast: false
reversible: true
name: DISC (Primary complex) FADD, CASP8, CASP10_containment

327650
type: SpeciesReference
stoichiometry: 1.0
species: meta Active DISC

meta Active DISC
type: Species
constant: false
initial amount: NaN
has part: http://identifiers.org/ncbigene/8837
name: Active_DISC (Primary complex) FADD, CASP8, CASP10
has part: http://identifiers.org/ncbigene/355
initial concentration: NaN
in compartment: meta SPIKE cell
has only substance units: false
boundary condition: false

327637
type: SpeciesReference
stoichiometry: 1.0
species: meta Active FAS

327625
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CFLAR

meta Active CFLAR
type: Species
is encoded by: http://identifiers.org/ncbigene/8837
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CFLAR

meta Regulation of CASP3 on EIF4G3 using Proteolytic Processing
type: Reaction
product: 333342
is described by: http://identifiers.org/pubmed/10611228
reversible: false
modifier: 333354
fast: false
is: SBO:0000179
is described by: http://identifiers.org/pubmed/10672017
reactant: 333330
name: Regulation_of_CASP3_on_EIF4G3_using_Proteolytic Processing

333342
type: SpeciesReference
stoichiometry: 1.0
species: meta Active EIF4G3

meta Active EIF4G3
type: Species
is encoded by: http://identifiers.org/ncbigene/8672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4G3

333330
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive EIF4G3

meta NonActive EIF4G3
type: Species
is encoded by: http://identifiers.org/ncbigene/8672
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4G3

meta Regulation of CFLAR on FADD using Physical Interaction
type: Reaction
modifier: 333501
product: 333488
reactant: 333476
is described by: http://identifiers.org/pubmed/9217161
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CFLAR_on_FADD_using_Physical Interaction

333488
type: SpeciesReference
stoichiometry: 1.0
species: meta Active FADD

333476
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive FADD

meta chromatin condensation
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: chromatin condensation

meta Regulation of DIABLO on BIRC2 using Physical Interaction
type: Reaction
modifier: 327746
product: 327734
reactant: 327722
is described by: http://identifiers.org/pubmed/10929712
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_DIABLO_on_BIRC2_using_Physical Interaction

meta Active DIABLO
type: Species
is encoded by: http://identifiers.org/ncbigene/56616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DIABLO

327734
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BIRC2

meta Active BIRC2
type: Species
is encoded by: http://identifiers.org/ncbigene/329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC2

327722
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC2

meta NonActive BIRC2
type: Species
is encoded by: http://identifiers.org/ncbigene/329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BIRC2

meta NonActive GOLGA3
type: Species
is encoded by: http://identifiers.org/ncbigene/2802
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_GOLGA3

meta Regulation of LRDD on CASP2 using Physical Interaction
type: Reaction
modifier: 331900
product: 331888
reactant: 331876
is described by: http://identifiers.org/pubmed/15073321
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_LRDD_on_CASP2_using_Physical Interaction

meta Active LRDD
type: Species
is encoded by: http://identifiers.org/ncbigene/55367
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_LRDD

331888
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP2

meta Active CASP2
type: Species
is encoded by: http://identifiers.org/ncbigene/835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP2

331876
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP2

meta NonActive CASP2
type: Species
is encoded by: http://identifiers.org/ncbigene/835
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP2

meta Regulation of PPP1CA on BAD using Dephosphorylation
type: Reaction
modifier: 331284
product: 331272
reactant: 331260
is described by: http://identifiers.org/pubmed/10811615
is: SBO:0000330
fast: false
reversible: false
name: Regulation_of_PPP1CA_on_BAD_using_Dephosphorylation

meta Active PPP1CA
type: Species
is encoded by: http://identifiers.org/ncbigene/5499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_PPP1CA

331272
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAD

331260
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAD

meta Regulation of FASLG on FAS using Physical Interaction
type: Reaction
modifier: 330049
is described by: http://identifiers.org/pubmed/9228058
name: Regulation_of_FASLG_on_FAS_using_Physical Interaction
product: 330036
is: SBO:0000181
fast: false
reversible: false
is described by: http://identifiers.org/pubmed/9126929
reactant: 330024

meta Active FASLG
type: Species
is encoded by: http://identifiers.org/ncbigene/356
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_FASLG

330036
type: SpeciesReference
stoichiometry: 1.0
species: meta Active FAS

330024
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive FAS

meta Regulation of CASP3 on EIF3J using Proteolytic Processing
type: Reaction
modifier: 327963
product: 327950
reactant: 327938
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF3J_using_Proteolytic Processing

327950
type: SpeciesReference
stoichiometry: 1.0
species: meta Active EIF3J

meta Active EIF3J
type: Species
is encoded by: http://identifiers.org/ncbigene/8669
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF3J

327938
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive EIF3J

meta NonActive EIF3J
type: Species
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constant: false
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meta Regulation of FADD on CASP8 using Physical Interaction
type: Reaction
modifier: 332661
product: 332649
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is described by: http://identifiers.org/pubmed/8681376
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_FADD_on_CASP8_using_Physical Interaction

332649
type: SpeciesReference
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species: meta Active CASP8

332637
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species: meta NonActive CASP8

meta Regulation of TNFRSF10B on RIPK1 using Physical Interaction
type: Reaction
modifier: 328593
product: 328581
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is described by: http://identifiers.org/pubmed/9430227
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFRSF10B_on_RIPK1_using_Physical Interaction

meta Active TNFRSF10B
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name: Active_TNFRSF10B

328581
type: SpeciesReference
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species: meta Active RIPK1

328569
type: SpeciesReference
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species: meta NonActive RIPK1

meta Regulation of BIRC2 on CASP7 using Physical Interaction
type: Reaction
modifier: 328630
product: 328618
reactant: 328605
is described by: http://identifiers.org/pubmed/9384571
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC2_on_CASP7_using_Physical Interaction

328618
type: SpeciesReference
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species: meta Active CASP7

meta Active CASP7
type: Species
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328605
type: SpeciesReference
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species: meta NonActive CASP7

meta NonActive CASP7
type: Species
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meta Regulation of CASP2 on GOLGA3 using Proteolytic Processing
type: Reaction
modifier: 330483
product: 330471
reactant: 330459
is described by: http://identifiers.org/pubmed/10791974
is: SBO:0000179
fast: false
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name: Regulation_of_CASP2_on_GOLGA3_using_Proteolytic Processing

330471
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species: meta Active GOLGA3

meta Active GOLGA3
type: Species
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330459
type: SpeciesReference
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species: meta NonActive GOLGA3

meta Regulation of DAPK3 on MYL10 using Phosphorylation
type: Reaction
is described by: http://identifiers.org/pubmed/11781833
is: SBO:0000216
is described by: http://identifiers.org/pubmed/10356987
fast: false
product: 334626
reactant: 334613
is described by: http://identifiers.org/pubmed/15096528
name: Regulation_of_DAPK3_on_MYL10_using_Phosphorylation
modifier: 334638
reversible: false

334626
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species: meta Active MYL10

meta Active MYL10
type: Species
is encoded by: http://identifiers.org/ncbigene/93408
constant: false
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initial concentration: NaN
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334613
type: SpeciesReference
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species: meta NonActive MYL10

meta NonActive MYL10
type: Species
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name: NonActive_MYL10

meta Regulation of AIFM1 on DNA fragmentation using Other
type: Reaction
modifier: 332080
product: 332068
reactant: 332056
is described by: http://identifiers.org/pubmed/9989411
is: SBO:0000396
fast: false
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name: Regulation_of_AIFM1_on_DNA fragmentation_using_Other

meta Active AIFM1
type: Species
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name: Active_AIFM1

332068
type: SpeciesReference
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species: meta DNA fragmentation

meta DNA fragmentation
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
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in compartment: meta SPIKE cell
name: DNA fragmentation

332056
type: SpeciesReference
stoichiometry: 1.0
species: meta DNA fragmentation

meta mRNA XIAP
type: Species
is encoded by: http://identifiers.org/ncbigene/331
constant: false
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_XIAP

meta RLC nonmuscle
type: Species
boundary condition: false
name: mysoin light chains, regulatory non muscle
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has part: http://identifiers.org/ncbigene/93408
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constant: false
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has part: http://identifiers.org/ncbigene/103910
initial amount: NaN
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meta Regulation of TNFSF10 on TNFRSF10C using Physical Interaction
type: Reaction
modifier: 333170
product: 333158
reactant: 333145
is described by: http://identifiers.org/pubmed/9082980
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFSF10_on_TNFRSF10C_using_Physical Interaction

meta Active TNFSF10
type: Species
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name: Active_TNFSF10

333158
type: SpeciesReference
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species: meta Active TNFRSF10C

meta Active TNFRSF10C
type: Species
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initial amount: NaN
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name: Active_TNFRSF10C

333145
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive TNFRSF10C

meta NonActive TNFRSF10C
type: Species
is encoded by: http://identifiers.org/ncbigene/8794
constant: false
boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TNFRSF10C

meta Active IKBKB
type: Species
is encoded by: http://identifiers.org/ncbigene/3551
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: Active_IKBKB

meta cap independent translation
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: IRES-mediated translation

meta Active BIRC7
type: Species
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constant: false
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initial concentration: NaN
initial amount: NaN
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name: Active_BIRC7

meta Regulation of DAPK1 on MYL5 using Phosphorylation
type: Reaction
reversible: false
modifier: 334783
is described by: http://identifiers.org/pubmed/11485996
reactant: 334759
product: 334771
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is described by: http://identifiers.org/pubmed/15002035
fast: false
name: Regulation_of_DAPK1_on_MYL5_using_Phosphorylation
is described by: http://identifiers.org/pubmed/14600263

334759
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL5

meta NonActive MYL5
type: Species
is encoded by: http://identifiers.org/ncbigene/4636
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: NonActive_MYL5

334771
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL5

meta Active MYL5
type: Species
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL5

meta Regulation of GORASP1 on Golgi fragmentation using Other
type: Reaction
modifier: 332298
product: 332286
reactant: 332274
is described by: http://identifiers.org/pubmed/9346242
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_GORASP1_on_Golgi fragmentation_using_Other

332286
type: SpeciesReference
stoichiometry: 1.0
species: meta Golgi fragmentation

meta Golgi fragmentation
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Golgi fragmentation

332274
type: SpeciesReference
stoichiometry: 1.0
species: meta Golgi fragmentation

meta Active NFKBIB
type: Species
is encoded by: http://identifiers.org/ncbigene/4793
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_NFKBIB

meta Regulation of BBC3 on BCL2 using Physical Interaction
type: Reaction
modifier: 331574
product: 331562
reactant: 331550
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_BCL2_using_Physical Interaction

331562
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2

331550
type: SpeciesReference
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species: meta NonActive BCL2

meta Regulation of BIRC7 on CASP3 using Physical Interaction
type: Reaction
modifier: 334298
product: 334286
reactant: 334274
is described by: http://identifiers.org/pubmed/9990849
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC7_on_CASP3_using_Physical Interaction

334286
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP3

334274
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP3

meta Active BCL2L10
type: Species
is encoded by: http://identifiers.org/ncbigene/10017
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BCL2L10

meta Regulation of CASP8 on BID using Proteolytic Processing
type: Reaction
is: SBO:0000179
is described by: http://identifiers.org/pubmed/9727491
modifier: 332807
name: Regulation_of_CASP8_on_BID_using_Proteolytic Processing
is described by: http://identifiers.org/pubmed/9727492
reactant: 332783
reversible: false
fast: false
product: 332795

332783
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BID

meta NonActive BID
type: Species
is encoded by: http://identifiers.org/ncbigene/637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BID

332795
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BID

meta Active BID
type: Species
is encoded by: http://identifiers.org/ncbigene/637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BID

meta Regulation of DAPK1 on DAPK3 using Phosphorylation
type: Reaction
modifier: 332189
product: 332177
reactant: 332164
is described by: http://identifiers.org/pubmed/15367680
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_DAPK1_on_DAPK3_using_Phosphorylation

332177
type: SpeciesReference
stoichiometry: 1.0
species: meta Active DAPK3

332164
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive DAPK3

meta Regulation of CDK1 on BIRC5 using Phosphorylation
type: Reaction
reversible: false
fast: false
name: Regulation_of_CDK1_on_BIRC5_using_Phosphorylation
is described by: http://identifiers.org/pubmed/12517802
product: 333742
modifier: 333754
is: SBO:0000216
reactant: 333730
is described by: http://identifiers.org/pubmed/11069302

333742
type: SpeciesReference
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species: meta Active BIRC5

meta Active BIRC5
type: Species
is encoded by: http://identifiers.org/ncbigene/332
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC5

meta Active CDK1
type: Species
is encoded by: http://identifiers.org/ncbigene/983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CDK1

333730
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC5

meta Regulation of CASP10 on RIPK1 using Proteolytic Processing
type: Reaction
modifier: 334008
product: 333996
reactant: 333984
is described by: http://identifiers.org/pubmed/16186808
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP10_on_RIPK1_using_Proteolytic Processing

meta Active CASP10
type: Species
is encoded by: http://identifiers.org/ncbigene/843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CASP10

333996
type: SpeciesReference
stoichiometry: 1.0
species: meta Active RIPK1

333984
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive RIPK1

meta NonActive XIAP
type: Species
is encoded by: http://identifiers.org/ncbigene/331
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_XIAP

meta NonActive AIFM1
type: Species
is encoded by: http://identifiers.org/ncbigene/9131
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_AIFM1

meta Regulation of BIRC8 on CASP3 using Physical Interaction
type: Reaction
modifier: 334334
product: 334322
reactant: 334310
is described by: http://identifiers.org/pubmed/9990849
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC8_on_CASP3_using_Physical Interaction

meta Active BIRC8
type: Species
is encoded by: http://identifiers.org/ncbigene/112401
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIRC8

334322
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP3

334310
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP3

meta Regulation of TNFRSF10A on FADD using Physical Interaction
type: Reaction
fast: false
modifier: 331972
name: Regulation_of_TNFRSF10A_on_FADD_using_Physical Interaction
is: SBO:0000181
reversible: false
is described by: http://identifiers.org/pubmed/9430227
reactant: 331948
product: 331960
is described by: http://identifiers.org/pubmed/9430228

331948
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive FADD

331960
type: SpeciesReference
stoichiometry: 1.0
species: meta Active FADD

meta Regulation of CASP6 on LMNA using Proteolytic Processing
type: Reaction
modifier: 330521
product: 330509
reactant: 330496
is described by: http://identifiers.org/pubmed/8710882
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP6_on_LMNA_using_Proteolytic Processing

330509
type: SpeciesReference
stoichiometry: 1.0
species: meta Active LMNA

meta Active LMNA
type: Species
is encoded by: http://identifiers.org/ncbigene/4000
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_LMNA

330496
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive LMNA

meta NonActive LMNA
type: Species
is encoded by: http://identifiers.org/ncbigene/4000
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_LMNA

meta Regulation of CASP7 on DFFA using Proteolytic Processing
type: Reaction
modifier: 328484
product: 328472
reactant: 328460
is described by: http://identifiers.org/pubmed/10318789
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP7_on_DFFA_using_Proteolytic Processing

328472
type: SpeciesReference
stoichiometry: 1.0
species: meta Active DFFA

328460
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive DFFA

meta Active EIF2A
type: Species
is encoded by: http://identifiers.org/ncbigene/83939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF2A

meta Regulation of IKK on NFKBIA using Phosphorylation
type: Reaction
modifier: 335107
product: 335095
reactant: 335083
is described by: http://identifiers.org/pubmed/10644043
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_IKK_on_NFKBIA_using_Phosphorylation

335095
type: SpeciesReference
stoichiometry: 1.0
species: meta Active NFKBIA

335083
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive NFKBIA

meta NonActive NFKBIA
type: Species
is encoded by: http://identifiers.org/ncbigene/4792
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_NFKBIA

meta Regulation of TNFSF10 on TNFRSF10A using Physical Interaction
type: Reaction
modifier: 330231
product: 330219
reactant: 330206
is described by: http://identifiers.org/pubmed/15538968
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFSF10_on_TNFRSF10A_using_Physical Interaction

330219
type: SpeciesReference
stoichiometry: 1.0
species: meta Active TNFRSF10A

330206
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive TNFRSF10A

meta NonActive TNFRSF10A
type: Species
is encoded by: http://identifiers.org/ncbigene/8797
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TNFRSF10A

meta Active BIK
type: Species
is encoded by: http://identifiers.org/ncbigene/638
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_BIK

meta Regulation of CASP3 on BCL2 using Proteolytic Processing
type: Reaction
modifier: 333537
product: 333525
reactant: 333513
is described by: http://identifiers.org/pubmed/9395403
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_BCL2_using_Proteolytic Processing

333525
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2

333513
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2

meta Regulation of DFFB on DNA fragmentation using Transcription Regulation
type: Reaction
modifier: 335398
product: 335385
reactant: 335373
is described by: http://identifiers.org/pubmed/9108473
is: SBO:0000183
fast: false
reversible: false
name: Regulation_of_DFFB_on_DNA fragmentation_using_Transcription Regulation

meta Active DFFB
type: Species
is encoded by: http://identifiers.org/ncbigene/1677
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_DFFB

335385
type: SpeciesReference
stoichiometry: 1.0
species: meta DNA fragmentation

335373
type: SpeciesReference
stoichiometry: 1.0
species: meta DNA fragmentation

meta Regulation of EIF4B on protein translation using Other
type: Reaction
modifier: 328109
product: 328097
reactant: 328084
is described by: http://identifiers.org/pubmed/14635255
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF4B_on_protein translation_using_Other

meta Active EIF4B
type: Species
is encoded by: http://identifiers.org/ncbigene/1975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4B

328097
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

meta protein translation
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: cap-dependent translation initiation

328084
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

meta Regulation of AKT1 on BAD using Phosphorylation
type: Reaction
reactant: 331296
is: SBO:0000216
name: Regulation_of_AKT1_on_BAD_using_Phosphorylation
is described by: http://identifiers.org/pubmed/14737178
fast: false
is described by: http://identifiers.org/pubmed/16341064
is described by: http://identifiers.org/pubmed/9346240
is described by: http://identifiers.org/pubmed/9381178
product: 331308
reversible: false
modifier: 331320

331296
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAD

331308
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAD

meta Active AKT1
type: Species
is encoded by: http://identifiers.org/ncbigene/207
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_AKT1

meta Active ACIN1
type: Species
is encoded by: http://identifiers.org/ncbigene/22985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_ACIN1

meta Active TRAF2
type: Species
is encoded by: http://identifiers.org/ncbigene/7186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TRAF2

meta Regulation of BAK1 on AIFM1 using Indirect
type: Reaction
modifier: 332008
product: 331996
reactant: 331984
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAK1_on_AIFM1_using_Indirect

331996
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stoichiometry: 1.0
species: meta Active AIFM1

331984
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive AIFM1

meta Regulation of DIABLO on BIRC3 using Physical Interaction
type: Reaction
modifier: 327782
product: 327770
reactant: 327758
is described by: http://identifiers.org/pubmed/10929712
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_DIABLO_on_BIRC3_using_Physical Interaction

327770
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BIRC3

327758
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC3

meta Active SH3GLB1
type: Species
is encoded by: http://identifiers.org/ncbigene/51100
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_SH3GLB1

meta Regulation of CASP3 on EIF4G2 using Proteolytic Processing
type: Reaction
name: Regulation_of_CASP3_on_EIF4G2_using_Proteolytic Processing
fast: false
modifier: 333863
is described by: http://identifiers.org/pubmed/10672017
product: 333851
is described by: http://identifiers.org/pubmed/10611228
reactant: 333839
reversible: false
is: SBO:0000179

333851
type: SpeciesReference
stoichiometry: 1.0
species: meta Active EIF4G2

333839
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive EIF4G2

meta NonActive EIF4G2
type: Species
is encoded by: http://identifiers.org/ncbigene/1982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4G2

meta Regulation of DIABLO on BIRC5 using Physical Interaction
type: Reaction
modifier: 327854
product: 327842
reactant: 327830
is described by: http://identifiers.org/pubmed/12660240
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_DIABLO_on_BIRC5_using_Physical Interaction

327842
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BIRC5

327830
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC5

meta Regulation of PARP1 on DNA repair using Other
type: Reaction
modifier: 329940
product: 329928
reactant: 329915
is described by: http://identifiers.org/pubmed/18468963
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_PARP1_on_DNA repair_using_Other

meta Active PARP1
type: Species
is encoded by: http://identifiers.org/ncbigene/142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_PARP1

329928
type: SpeciesReference
stoichiometry: 1.0
species: meta DNA repair

329915
type: SpeciesReference
stoichiometry: 1.0
species: meta DNA repair

meta Regulation of CRADD on CASP2 using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/8985253
reactant: 331441
is: SBO:0000181
fast: false
modifier: 331465
name: Regulation_of_CRADD_on_CASP2_using_Physical Interaction
is described by: http://identifiers.org/pubmed/9695946
reversible: false
product: 331453

331441
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP2

meta Active CRADD
type: Species
is encoded by: http://identifiers.org/ncbigene/8738
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CRADD

331453
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP2

meta Regulation of CASP3 on EIF2S2 using Proteolytic Processing
type: Reaction
modifier: 333718
product: 333705
reactant: 333693
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF2S2_using_Proteolytic Processing

333705
type: SpeciesReference
stoichiometry: 1.0
species: meta Active EIF2S2

meta Active EIF2S2
type: Species
is encoded by: http://identifiers.org/ncbigene/8894
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF2S2

333693
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive EIF2S2

meta Regulation of CASP8 on RIPK1 using Proteolytic Processing
type: Reaction
modifier: 330158
is described by: http://identifiers.org/pubmed/11002417
is described by: http://identifiers.org/pubmed/8657102
is: SBO:0000179
is described by: http://identifiers.org/pubmed/11042193
is described by: http://identifiers.org/pubmed/12842894
reactant: 330133
is described by: http://identifiers.org/pubmed/11002422
reversible: false
product: 330145
fast: false
name: Regulation_of_CASP8_on_RIPK1_using_Proteolytic Processing
is described by: http://identifiers.org/pubmed/10469655

330133
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive RIPK1

330145
type: SpeciesReference
stoichiometry: 1.0
species: meta Active RIPK1

meta Regulation of EIF4G2 on BIRC2 using Translational Regulation
type: Reaction
modifier: 335324
product: 335312
reactant: 335300
is described by: http://identifiers.org/pubmed/14960583
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_BIRC2_using_Translational Regulation

335312
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC2

335300
type: SpeciesReference
stoichiometry: 1.0
species: meta mRNA BIRC2

meta mRNA BIRC2
type: Species
is encoded by: http://identifiers.org/ncbigene/329
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_BIRC2

meta NonActive EIF4G1
type: Species
is encoded by: http://identifiers.org/ncbigene/1981
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4G1

meta NonActive DFFB
type: Species
is encoded by: http://identifiers.org/ncbigene/1677
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DFFB

meta Regulation of DAPK1 on MYL12B using Phosphorylation
type: Reaction
reactant: 334831
product: 334843
name: Regulation_of_DAPK1_on_MYL12B_using_Phosphorylation
reversible: false
is described by: http://identifiers.org/pubmed/14600263
is: SBO:0000216
fast: false
is described by: http://identifiers.org/pubmed/15002035
modifier: 334855
is described by: http://identifiers.org/pubmed/11485996

334831
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL12B

334843
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL12B

meta Regulation of TNFSF10 on TNFRSF10B using Physical Interaction
type: Reaction
modifier: 330194
product: 330182
reactant: 330170
is described by: http://identifiers.org/pubmed/15538968
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFSF10_on_TNFRSF10B_using_Physical Interaction

330182
type: SpeciesReference
stoichiometry: 1.0
species: meta Active TNFRSF10B

330170
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive TNFRSF10B

meta NonActive TNFRSF10B
type: Species
is encoded by: http://identifiers.org/ncbigene/8795
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TNFRSF10B

meta Regulation of BIRC2 on CASP9 using Physical Interaction
type: Reaction
modifier: 330701
is: SBO:0000181
reactant: 330677
reversible: false
is described by: http://identifiers.org/pubmed/9545235
product: 330689
name: Regulation_of_BIRC2_on_CASP9_using_Physical Interaction
is described by: http://identifiers.org/pubmed/9990849
fast: false

330677
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP9

330689
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP9

meta Regulation of SH3GLB1 on BAK1 using Physical Interaction
type: Reaction
modifier: 331826
product: 331814
reactant: 331802
is described by: http://identifiers.org/pubmed/16227588
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_SH3GLB1_on_BAK1_using_Physical Interaction

331814
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAK1

331802
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAK1

meta Regulation of BID on BAK1 using Physical Interaction
type: Reaction
modifier: 332443
product: 332431
reactant: 332419
is described by: http://identifiers.org/pubmed/10950869
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BID_on_BAK1_using_Physical Interaction

332431
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAK1

332419
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAK1

meta Regulation of EIF4G2 on XIAP using Translational Regulation
type: Reaction
modifier: 335288
product: 335276
reactant: 335264
is described by: http://identifiers.org/pubmed/11943866
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_XIAP_using_Translational Regulation

335276
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive XIAP

335264
type: SpeciesReference
stoichiometry: 1.0
species: meta mRNA XIAP

meta NonActive ACIN1
type: Species
is encoded by: http://identifiers.org/ncbigene/22985
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_ACIN1

meta Regulation of CASP2 on RIPK1 using Physical Interaction
type: Reaction
modifier: 333935
product: 333923
reactant: 333911
is described by: http://identifiers.org/pubmed/15590671
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CASP2_on_RIPK1_using_Physical Interaction

333923
type: SpeciesReference
stoichiometry: 1.0
species: meta Active RIPK1

333911
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive RIPK1

meta Regulation of CTNNB1 on cytosk stability using Other
type: Reaction
modifier: 332262
product: 332250
reactant: 332237
is described by: http://identifiers.org/pubmed/17854762
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_CTNNB1_on_cytosk. stability_using_Other

meta Active CTNNB1
type: Species
is encoded by: http://identifiers.org/ncbigene/1499
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_CTNNB1

332250
type: SpeciesReference
stoichiometry: 1.0
species: meta cytosk stability

332237
type: SpeciesReference
stoichiometry: 1.0
species: meta cytosk stability

meta Regulation of PMAIP1 on BCL2 using Physical Interaction
type: Reaction
fast: false
modifier: 331718
is described by: http://identifiers.org/pubmed/15725726
product: 331706
name: Regulation_of_PMAIP1_on_BCL2_using_Physical Interaction
reversible: false
is: SBO:0000181
reactant: 331694
is described by: http://identifiers.org/pubmed/10807576

331706
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2

331694
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2

meta Regulation of BCL2L1 on BAK1 using Physical Interaction
type: Reaction
modifier: 331211
product: 331199
fast: false
reversible: false
is: SBO:0000181
reactant: 331187
is described by: http://identifiers.org/pubmed/18178565
name: Regulation_of_BCL2L1_on_BAK1_using_Physical Interaction
is described by: http://identifiers.org/pubmed/11175750

331199
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAK1

331187
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAK1

meta Regulation of BAD on BCL2L1 using Physical Interaction
type: Reaction
reversible: false
reactant: 333073
fast: false
is: SBO:0000181
is described by: http://identifiers.org/pubmed/11583631
modifier: 333097
name: Regulation_of_BAD_on_BCL2L1_using_Physical Interaction
is described by: http://identifiers.org/pubmed/11494146
is described by: http://identifiers.org/pubmed/11483855
is described by: http://identifiers.org/pubmed/7834748
product: 333085

333073
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2L1

333085
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2L1

meta Regulation of ACIN1 on chromatin condensation using Transcription Regulation
type: Reaction
modifier: 335434
product: 335422
reactant: 335410
is described by: http://identifiers.org/pubmed/10490026
is: SBO:0000183
fast: false
reversible: false
name: Regulation_of_ACIN1_on_chromatin condensation_using_Transcription Regulation

335422
type: SpeciesReference
stoichiometry: 1.0
species: meta chromatin condensation

335410
type: SpeciesReference
stoichiometry: 1.0
species: meta chromatin condensation

meta NonActive DAPK1
type: Species
is encoded by: http://identifiers.org/ncbigene/1612
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DAPK1

meta Regulation of CASP10 on BID using Proteolytic Processing
type: Reaction
modifier: 334080
product: 334068
reactant: 334056
is described by: http://identifiers.org/pubmed/16186808
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP10_on_BID_using_Proteolytic Processing

334068
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BID

334056
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BID

meta Regulation of CASP3 on CASP8 using Proteolytic Processing
type: Reaction
modifier: 331175
product: 331163
reactant: 331150
is described by: http://identifiers.org/pubmed/9922454
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP8_using_Proteolytic Processing

331163
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP8

331150
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP8

meta Regulation of CASP3 on BIRC2 using Proteolytic Processing
type: Reaction
modifier: 329066
product: 329054
reactant: 329042
is described by: http://identifiers.org/pubmed/11106668
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_BIRC2_using_Proteolytic Processing

329054
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BIRC2

329042
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC2

meta Regulation of BAK1 on DIABLO using Indirect
type: Reaction
modifier: 332880
product: 332868
reactant: 332855
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAK1_on_DIABLO_using_Indirect

332868
type: SpeciesReference
stoichiometry: 1.0
species: meta Active DIABLO

332855
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive DIABLO

meta NonActive DIABLO
type: Species
is encoded by: http://identifiers.org/ncbigene/56616
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_DIABLO

meta Regulation of EIF4G2 on BCL2 using Translational Regulation
type: Reaction
modifier: 335252
product: 335240
reactant: 335228
is described by: http://identifiers.org/pubmed/18450493
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_BCL2_using_Translational Regulation

335240
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2

335228
type: SpeciesReference
stoichiometry: 1.0
species: meta mRNA BCL2

meta mRNA BCL2
type: Species
is encoded by: http://identifiers.org/ncbigene/596
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_BCL2

meta Regulation of EIF3J on protein translation using Dephosphorylation
type: Reaction
modifier: 328185
product: 328172
reactant: 328159
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000330
fast: false
reversible: false
name: Regulation_of_EIF3J_on_protein translation_using_Dephosphorylation

328172
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

328159
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

meta Regulation of IKK on NFKBIB using Phosphorylation
type: Reaction
modifier: 335143
product: 335131
reactant: 335119
is described by: http://identifiers.org/pubmed/10644043
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_IKK_on_NFKBIB_using_Phosphorylation

335131
type: SpeciesReference
stoichiometry: 1.0
species: meta Active NFKBIB

335119
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive NFKBIB

meta NonActive NFKBIB
type: Species
is encoded by: http://identifiers.org/ncbigene/4793
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_NFKBIB

meta Regulation of HTRA2 on BIRC3 using Physical Interaction
type: Reaction
modifier: 328340
product: 328328
reactant: 328315
is described by: http://identifiers.org/pubmed/11583623
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_HTRA2_on_BIRC3_using_Physical Interaction

meta Active HTRA2
type: Species
is encoded by: http://identifiers.org/ncbigene/27429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_HTRA2

328328
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BIRC3

328315
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC3

meta Regulation of DAPK3 on MYL7 using Phosphorylation
type: Reaction
fast: false
is described by: http://identifiers.org/pubmed/15096528
is described by: http://identifiers.org/pubmed/11781833
name: Regulation_of_DAPK3_on_MYL7_using_Phosphorylation
product: 334698
is: SBO:0000216
reversible: false
modifier: 334710
reactant: 334686
is described by: http://identifiers.org/pubmed/10356987

334698
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL7

334686
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL7

meta Active EIF4G1
type: Species
is encoded by: http://identifiers.org/ncbigene/1981
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4G1

meta Regulation of BIRC6 on HTRA2 using Ubiquitination
type: Reaction
modifier: 329722
product: 329710
reactant: 329697
is described by: http://identifiers.org/pubmed/15781261
is: SBO:0000224
fast: false
reversible: false
name: Regulation_of_BIRC6_on_HTRA2_using_Ubiquitination

329710
type: SpeciesReference
stoichiometry: 1.0
species: meta Active HTRA2

329697
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive HTRA2

meta NonActive HTRA2
type: Species
is encoded by: http://identifiers.org/ncbigene/27429
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_HTRA2

meta NonActive CYCS
type: Species
is encoded by: http://identifiers.org/ncbigene/54205
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CYCS

meta Regulation of cytosk stability on membrane blebbing using Other
type: Reaction
modifier: 330085
product: 330073
reactant: 330061
is described by: http://identifiers.org/pubmed/10459006
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_cytosk. stability_on_membrane blebbing_using_Other

330073
type: SpeciesReference
stoichiometry: 1.0
species: meta membrane blebbing

330061
type: SpeciesReference
stoichiometry: 1.0
species: meta membrane blebbing

meta NonActive CASP10
type: Species
is encoded by: http://identifiers.org/ncbigene/843
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP10

meta Regulation of BAD on BCL2 using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/11483855
is described by: http://identifiers.org/pubmed/11583631
fast: false
reversible: false
modifier: 334044
name: Regulation_of_BAD_on_BCL2_using_Physical Interaction
is: SBO:0000181
is described by: http://identifiers.org/pubmed/7834748
reactant: 334020
is described by: http://identifiers.org/pubmed/9463381
product: 334032

334020
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2

334032
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2

meta Regulation of TNFRSF1A on TRADD using Physical Interaction
type: Reaction
reactant: 330315
product: 330327
is: SBO:0000181
is described by: http://identifiers.org/pubmed/7758105
fast: false
is described by: http://identifiers.org/pubmed/8565075
modifier: 330339
reversible: false
name: Regulation_of_TNFRSF1A_on_TRADD_using_Physical Interaction

330315
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive TRADD

meta NonActive TRADD
type: Species
is encoded by: http://identifiers.org/ncbigene/8717
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TRADD

330327
type: SpeciesReference
stoichiometry: 1.0
species: meta Active TRADD

meta Active TNFRSF1A
type: Species
is encoded by: http://identifiers.org/ncbigene/7132
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_TNFRSF1A

meta Regulation of FADD on ATG5 using Physical Interaction
type: Reaction
modifier: 327818
product: 327806
reactant: 327794
is described by: http://identifiers.org/pubmed/15778222
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_FADD_on_ATG5_using_Physical Interaction

327806
type: SpeciesReference
stoichiometry: 1.0
species: meta Active ATG5

meta Active ATG5
type: Species
is encoded by: http://identifiers.org/ncbigene/9474
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_ATG5

327794
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive ATG5

meta NonActive ATG5
type: Species
is encoded by: http://identifiers.org/ncbigene/9474
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_ATG5

meta Regulation of EIF2A on protein translation using Other
type: Reaction
modifier: 328072
product: 328060
reactant: 328048
is described by: http://identifiers.org/pubmed/14635255
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF2A_on_protein translation_using_Other

328060
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

328048
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

meta Regulation of TNFRSF1A on RIPK1 using Physical Interaction
type: Reaction
modifier: 330303
product: 330291
reactant: 330279
is described by: http://identifiers.org/pubmed/8612133
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFRSF1A_on_RIPK1_using_Physical Interaction

330291
type: SpeciesReference
stoichiometry: 1.0
species: meta Active RIPK1

330279
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive RIPK1

meta Regulation of BIRC5 on CASP9 using Physical Interaction
type: Reaction
modifier: 328958
product: 328946
reactant: 328934
is described by: http://identifiers.org/pubmed/11069302
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC5_on_CASP9_using_Physical Interaction

328946
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP9

328934
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP9

meta Regulation of CASP3 on EIF4G1 using Proteolytic Processing
type: Reaction
modifier: 333317
is: SBO:0000179
reactant: 333292
name: Regulation_of_CASP3_on_EIF4G1_using_Proteolytic Processing
is described by: http://identifiers.org/pubmed/9819442
product: 333304
fast: false
is described by: http://identifiers.org/pubmed/10611228
reversible: false

333292
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive EIF4G1

333304
type: SpeciesReference
stoichiometry: 1.0
species: meta Active EIF4G1

meta Regulation of MYL5 on myosin II using Other
type: Reaction
modifier: 334407
product: 334395
reactant: 334383
is described by: http://identifiers.org/pubmed/10047526
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_MYL5_on_myosin II_using_Other

334395
type: SpeciesReference
stoichiometry: 1.0
species: meta Active myosin II

334383
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive myosin II

meta Regulation of BAX on HTRA2 using Indirect
type: Reaction
modifier: 332916
product: 332904
reactant: 332892
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAX_on_HTRA2_using_Indirect

332904
type: SpeciesReference
stoichiometry: 1.0
species: meta Active HTRA2

332892
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive HTRA2

meta Regulation of BCL2L2 on BAK1 using Physical Interaction
type: Reaction
modifier: 329537
is described by: http://identifiers.org/pubmed/18178565
name: Regulation_of_BCL2L2_on_BAK1_using_Physical Interaction
product: 329525
is: SBO:0000181
reversible: false
is described by: http://identifiers.org/pubmed/15901672
fast: false
is described by: http://identifiers.org/pubmed/10381646
reactant: 329513

329525
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAK1

329513
type: SpeciesReference
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species: meta NonActive BAK1

meta NonActive EIF4B
type: Species
is encoded by: http://identifiers.org/ncbigene/1975
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF4B

meta Regulation of DAPK1 on DAPK1 using Phosphorylation
type: Reaction
modifier: 332370
product: 332358
reactant: 332346
is described by: http://identifiers.org/pubmed/11579085
is: SBO:0000216
fast: false
reversible: false
name: Regulation_of_DAPK1_on_DAPK1_using_Phosphorylation

332358
type: SpeciesReference
stoichiometry: 1.0
species: meta Active DAPK1

332346
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive DAPK1

meta Active SPTAN1
type: Species
is encoded by: http://identifiers.org/ncbigene/6709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_SPTAN1

meta Regulation of BIRC3 on CASP3 using Physical Interaction
type: Reaction
reactant: 328787
is: SBO:0000181
fast: false
name: Regulation_of_BIRC3_on_CASP3_using_Physical Interaction
is described by: http://identifiers.org/pubmed/9384571
modifier: 328811
reversible: false
product: 328799
is described by: http://identifiers.org/pubmed/9990849
is described by: http://identifiers.org/pubmed/12042762

328787
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP3

328799
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP3

meta NonActive IKK
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_IKK complex

meta Regulation of BAX on CYCS using Indirect
type: Reaction
fast: false
product: 333451
reversible: false
is described by: http://identifiers.org/pubmed/12232790
name: Regulation_of_BAX_on_CYCS_using_Indirect
reactant: 333439
modifier: 333463
is: SBO:0000396
is described by: http://identifiers.org/pubmed/11326099

333451
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CYCS

333439
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CYCS

meta Regulation of EIF4G2 on CDK1 using Translational Regulation
type: Reaction
modifier: 335216
product: 335204
reactant: 335192
is described by: http://identifiers.org/pubmed/18450493
is: SBO:0000184
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_CDK1_using_Translational Regulation

335204
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CDK1

335192
type: SpeciesReference
stoichiometry: 1.0
species: meta mRNA CDK1

meta mRNA CDK1
type: Species
is encoded by: http://identifiers.org/ncbigene/983
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_CDK1

meta Regulation of ROCK1 on MYL7 using Phosphorylation
type: Reaction
is: SBO:0000216
fast: false
is described by: http://identifiers.org/pubmed/8702756
reversible: false
is described by: http://identifiers.org/pubmed/11283607
modifier: 335071
name: Regulation_of_ROCK1_on_MYL7_using_Phosphorylation
reactant: 335047
product: 335059

335047
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL7

335059
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL7

meta Regulation of DAPK3 on MYL5 using Phosphorylation
type: Reaction
product: 334587
is: SBO:0000216
is described by: http://identifiers.org/pubmed/15096528
reversible: false
name: Regulation_of_DAPK3_on_MYL5_using_Phosphorylation
fast: false
is described by: http://identifiers.org/pubmed/10356987
reactant: 334574
modifier: 334600
is described by: http://identifiers.org/pubmed/11781833

334587
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL5

334574
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL5

meta Regulation of RIPK1 on FADD using Physical Interaction
type: Reaction
modifier: 332734
product: 332722
reactant: 332710
is described by: http://identifiers.org/pubmed/11002422
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_RIPK1_on_FADD_using_Physical Interaction

332722
type: SpeciesReference
stoichiometry: 1.0
species: meta Active FADD

332710
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive FADD

meta Regulation of DAPK3 on MYL12B using Phosphorylation
type: Reaction
is described by: http://identifiers.org/pubmed/11781833
is described by: http://identifiers.org/pubmed/10356987
reversible: false
product: 334662
is: SBO:0000216
modifier: 334674
is described by: http://identifiers.org/pubmed/15096528
reactant: 334650
fast: false
name: Regulation_of_DAPK3_on_MYL12B_using_Phosphorylation

334662
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL12B

334650
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL12B

meta Active EIF4EBP1
type: Species
is encoded by: http://identifiers.org/ncbigene/1978
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_EIF4EBP1

meta Regulation of HTRA2 on BIRC6 using Physical Interaction
type: Reaction
modifier: 328302
product: 328289
reactant: 328276
is described by: http://identifiers.org/pubmed/15200957
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_HTRA2_on_BIRC6_using_Physical Interaction

328289
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BIRC6

328276
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC6

meta Regulation of BID on BAX using Physical Interaction
type: Reaction
modifier: 332515
product: 332503
reactant: 332491
is described by: http://identifiers.org/pubmed/15574335
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BID_on_BAX_using_Physical Interaction

332503
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAX

332491
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAX

meta BCL2 fam
type: Species
has part: http://identifiers.org/ncbigene/599
boundary condition: false
has only substance units: false
constant: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
has part: http://identifiers.org/ncbigene/597
has part: http://identifiers.org/ncbigene/596
has part: http://identifiers.org/ncbigene/10017
has part: http://identifiers.org/ncbigene/4170
name: BCL2 family (Anti-apoptotic)
has part: http://identifiers.org/ncbigene/598

meta Regulation of HTRA2 on BIRC2 using Physical Interaction
type: Reaction
reactant: 328352
reversible: false
name: Regulation_of_HTRA2_on_BIRC2_using_Physical Interaction
is: SBO:0000181
product: 328364
modifier: 328376
is described by: http://identifiers.org/pubmed/11604410
is described by: http://identifiers.org/pubmed/11583623
fast: false

328352
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BIRC2

328364
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BIRC2

meta Regulation of EIF4G2 on EIF4G2 using Translational Regulation
type: Reaction
product: 335458
reactant: 335446
modifier: 335470
reversible: false
fast: false
is: SBO:0000184
name: Regulation_of_EIF4G2_on_EIF4G2_using_Translational Regulation
is described by: http://identifiers.org/pubmed/11943866
is described by: http://identifiers.org/pubmed/18003655

335458
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive EIF4G2

335446
type: SpeciesReference
stoichiometry: 1.0
species: meta mRNA EIF4G2

meta mRNA EIF4G2
type: Species
is encoded by: http://identifiers.org/ncbigene/1982
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: mRNA_EIF4G2

meta Regulation of CFLAR on CASP10 using Physical Interaction
type: Reaction
product: 330943
is described by: http://identifiers.org/pubmed/9289491
reversible: false
is described by: http://identifiers.org/pubmed/9228018
name: Regulation_of_CFLAR_on_CASP10_using_Physical Interaction
modifier: 330955
is: SBO:0000181
reactant: 330931
fast: false

330943
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP10

330931
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP10

meta Regulation of BAX on DIABLO using Indirect
type: Reaction
modifier: 332044
product: 332032
reactant: 332020
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAX_on_DIABLO_using_Indirect

332032
type: SpeciesReference
stoichiometry: 1.0
species: meta Active DIABLO

332020
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive DIABLO

meta Regulation of BCL2L1 on BAX using Physical Interaction
type: Reaction
modifier: 334152
is described by: http://identifiers.org/pubmed/9742125
is described by: http://identifiers.org/pubmed/11283018
is described by: http://identifiers.org/pubmed/18178565
is: SBO:0000181
reversible: false
reactant: 334128
is described by: http://identifiers.org/pubmed/9111042
fast: false
is described by: http://identifiers.org/pubmed/9153240
product: 334140
name: Regulation_of_BCL2L1_on_BAX_using_Physical Interaction

334128
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAX

334140
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAX

meta Regulation of CASP3 on ROCK1 using Proteolytic Processing
type: Reaction
modifier: 329103
product: 329090
reactant: 329078
is described by: http://identifiers.org/pubmed/11283607
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_ROCK1_using_Proteolytic Processing

329090
type: SpeciesReference
stoichiometry: 1.0
species: meta Active ROCK1

329078
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive ROCK1

meta NonActive ROCK1
type: Species
is encoded by: http://identifiers.org/ncbigene/6093
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_ROCK1

meta Regulation of CYCS on APAF1 using Physical Interaction
type: Reaction
modifier: 327890
product: 327878
reactant: 327866
is described by: http://identifiers.org/pubmed/9267021
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CYCS_on_APAF1_using_Physical Interaction

327878
type: SpeciesReference
stoichiometry: 1.0
species: meta Active APAF1

327866
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive APAF1

meta Regulation of BIRC6 on CASP9 using Physical Interaction
type: Reaction
modifier: 329030
product: 329018
reactant: 329006
is described by: http://identifiers.org/pubmed/15300255
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC6_on_CASP9_using_Physical Interaction

329018
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP9

329006
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP9

meta Regulation of CASP3 on CTNNB1 using Proteolytic Processing
type: Reaction
modifier: 328886
product: 328873
reactant: 328861
is described by: http://identifiers.org/pubmed/9348292
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CTNNB1_using_Proteolytic Processing

328873
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CTNNB1

328861
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CTNNB1

meta Regulation of BCL2L11 on BCL2L1 using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/9731710
is: SBO:0000181
fast: false
product: 331053
reactant: 331041
reversible: false
is described by: http://identifiers.org/pubmed/9430630
name: Regulation_of_BCL2L11_on_BCL2L1_using_Physical Interaction
modifier: 331065

331053
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2L1

331041
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2L1

meta Regulation of BIRC5 on CASP3 using Physical Interaction
type: Reaction
modifier: 333645
product: 333633
reactant: 333621
is described by: http://identifiers.org/pubmed/9850056
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC5_on_CASP3_using_Physical Interaction

333633
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP3

333621
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP3

meta Regulation of EIF2S2 on protein translation using Other
type: Reaction
modifier: 333244
product: 333231
reactant: 333219
is described by: http://identifiers.org/pubmed/14635255
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF2S2_on_protein translation_using_Other

333231
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

333219
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

meta Regulation of CFLAR on CASP8 using Physical Interaction
type: Reaction
modifier: 331936
product: 331924
reactant: 331912
is described by: http://identifiers.org/pubmed/9880531
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CFLAR_on_CASP8_using_Physical Interaction

331924
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP8

331912
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP8

meta NonActive SPTAN1
type: Species
is encoded by: http://identifiers.org/ncbigene/6709
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_SPTAN1

meta Regulation of LMNA on nuclear integrity using Other
type: Reaction
modifier: 332406
product: 332394
reactant: 332382
is described by: http://identifiers.org/pubmed/17504143
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_LMNA_on_nuclear integrity_using_Other

332394
type: SpeciesReference
stoichiometry: 1.0
species: meta nuclear integrity

meta nuclear integrity
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: nuclear integrity

332382
type: SpeciesReference
stoichiometry: 1.0
species: meta nuclear integrity

meta Regulation of BCL2 on BAX using Other
type: Reaction
name: Regulation_of_BCL2_on_BAX_using_Other
modifier: 334116
fast: false
reactant: 334092
product: 334104
is: SBO:0000396
is described by: http://identifiers.org/pubmed/8358790
reversible: false
is described by: http://identifiers.org/pubmed/9463381
is described by: http://identifiers.org/pubmed/9111042

334092
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAX

334104
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAX

meta Regulation of TNFRSF10A on TNFRSF10B using Physical Interaction
type: Reaction
modifier: 328263
product: 328250
reactant: 328237
is described by: http://identifiers.org/pubmed/9430228
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TNFRSF10A_on_TNFRSF10B_using_Physical Interaction

328250
type: SpeciesReference
stoichiometry: 1.0
species: meta Active TNFRSF10B

328237
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive TNFRSF10B

meta Regulation of CASP3 on SPTAN1 using Proteolytic Processing
type: Reaction
fast: false
name: Regulation_of_CASP3_on_SPTAN1_using_Proteolytic Processing
modifier: 333280
is described by: http://identifiers.org/pubmed/9624143
reactant: 333256
is described by: http://identifiers.org/pubmed/8910516
product: 333268
reversible: false
is: SBO:0000179

333256
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive SPTAN1

333268
type: SpeciesReference
stoichiometry: 1.0
species: meta Active SPTAN1

meta Regulation of GOLGA3 on Golgi fragmentation using Other
type: Reaction
modifier: 332334
product: 332322
reactant: 332310
is described by: http://identifiers.org/pubmed/9346242
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_GOLGA3_on_Golgi fragmentation_using_Other

332322
type: SpeciesReference
stoichiometry: 1.0
species: meta Golgi fragmentation

332310
type: SpeciesReference
stoichiometry: 1.0
species: meta Golgi fragmentation

meta ATP
type: Species
is: CHEBI:15422
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: ATP

meta BH3 fam
type: Species
has part: http://identifiers.org/ncbigene/90427
has part: http://identifiers.org/ncbigene/638
in compartment: meta SPIKE cell
has part: http://identifiers.org/ncbigene/8739
initial amount: NaN
boundary condition: false
has only substance units: false
has part: http://identifiers.org/ncbigene/5366
has part: http://identifiers.org/ncbigene/27113
has part: http://identifiers.org/ncbigene/572
has part: http://identifiers.org/ncbigene/10018
has part: http://identifiers.org/ncbigene/664
constant: false
initial concentration: NaN
has part: http://identifiers.org/ncbigene/637
name: BH3 family

meta Regulation of HTRA2 on XIAP using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/11604410
fast: false
reversible: false
is described by: http://identifiers.org/pubmed/11803371
is described by: http://identifiers.org/pubmed/11606597
is: SBO:0000181
modifier: 328412
product: 328400
reactant: 328388
name: Regulation_of_HTRA2_on_XIAP_using_Physical Interaction

328400
type: SpeciesReference
stoichiometry: 1.0
species: meta Active XIAP

328388
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive XIAP

meta Regulation of BCL2L11 on BAK1 using Physical Interaction
type: Reaction
modifier: 331138
product: 331125
reactant: 331113
is described by: http://identifiers.org/pubmed/12242151
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BCL2L11_on_BAK1_using_Physical Interaction

331125
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAK1

331113
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAK1

meta Regulation of ROCK1 on MYL12A using Phosphorylation
type: Reaction
fast: false
name: Regulation_of_ROCK1_on_MYL12A_using_Phosphorylation
reversible: false
is: SBO:0000216
reactant: 334903
modifier: 334927
is described by: http://identifiers.org/pubmed/11283607
product: 334915
is described by: http://identifiers.org/pubmed/8702756

334903
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL12A

334915
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL12A

meta Regulation of BAK1 on CYCS using Indirect
type: Reaction
is described by: http://identifiers.org/pubmed/11326099
is: SBO:0000396
reactant: 332819
is described by: http://identifiers.org/pubmed/12232790
name: Regulation_of_BAK1_on_CYCS_using_Indirect
reversible: false
product: 332831
fast: false
modifier: 332843

332819
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CYCS

332831
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CYCS

meta Regulation of CASP8 on CASP7 using Other
type: Reaction
modifier: 332771
product: 332758
reactant: 332746
is described by: http://identifiers.org/pubmed/18329793
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_CASP8_on_CASP7_using_Other

332758
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP7

332746
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP7

meta Regulation of TNFRSF10A on TRADD using Physical Interaction
type: Reaction
is: SBO:0000181
fast: false
product: 328691
is described by: http://identifiers.org/pubmed/9430227
reactant: 328679
modifier: 328703
reversible: false
is described by: http://identifiers.org/pubmed/9430228
name: Regulation_of_TNFRSF10A_on_TRADD_using_Physical Interaction

328691
type: SpeciesReference
stoichiometry: 1.0
species: meta Active TRADD

328679
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive TRADD

meta Regulation of CASP2 on BID using Proteolytic Processing
type: Reaction
modifier: 329139
product: 329127
reactant: 329115
is described by: http://identifiers.org/pubmed/11832478
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP2_on_BID_using_Proteolytic Processing

329127
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BID

329115
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BID

meta Regulation of BBC3 on MCL1 using Physical Interaction
type: Reaction
modifier: 329321
product: 329309
reactant: 329297
is described by: http://identifiers.org/pubmed/15694340
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_MCL1_using_Physical Interaction

329309
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MCL1

329297
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MCL1

meta Regulation of EIF4G1 on protein translation using Other
type: Reaction
product: 327987
is: SBO:0000396
modifier: 327999
is described by: http://identifiers.org/pubmed/10611228
fast: false
reactant: 327975
reversible: false
is described by: http://identifiers.org/pubmed/9819442
name: Regulation_of_EIF4G1_on_protein translation_using_Other

327987
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

327975
type: SpeciesReference
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species: meta protein translation

meta Regulation of BID on BCL2L1 using Physical Interaction
type: Reaction
reversible: false
is: SBO:0000181
product: 331017
fast: false
is described by: http://identifiers.org/pubmed/15694340
is described by: http://identifiers.org/pubmed/9727492
modifier: 331029
name: Regulation_of_BID_on_BCL2L1_using_Physical Interaction
reactant: 331004

331017
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2L1

331004
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2L1

meta Regulation of EIF2S3 on protein translation using Other
type: Reaction
modifier: 333206
product: 333194
reactant: 333182
is described by: http://identifiers.org/pubmed/14635255
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF2S3_on_protein translation_using_Other

333194
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

333182
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

meta Regulation of BAX on BAX using Physical Interaction
type: Reaction
modifier: 329175
product: 329163
reactant: 329151
is described by: http://identifiers.org/pubmed/9670005
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BAX_on_BAX_using_Physical Interaction

329163
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAX

329151
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAX

meta Regulation of CASP3 on CASP6 using Proteolytic Processing
type: Reaction
modifier: 333573
product: 333561
reactant: 333549
is described by: http://identifiers.org/pubmed/17899380
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP6_using_Proteolytic Processing

333561
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP6

333549
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP6

meta NonActive CASP6
type: Species
is encoded by: http://identifiers.org/ncbigene/839
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CASP6

meta NonActive CRADD
type: Species
is encoded by: http://identifiers.org/ncbigene/8738
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_CRADD

meta Regulation of LRDD on RIPK1 using Physical Interaction
type: Reaction
modifier: 331356
product: 331344
reactant: 331332
is described by: http://identifiers.org/pubmed/16360037
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_LRDD_on_RIPK1_using_Physical Interaction

331344
type: SpeciesReference
stoichiometry: 1.0
species: meta Active RIPK1

331332
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive RIPK1

meta Regulation of BAK1 on BAX using Physical Interaction
type: Reaction
modifier: 329903
product: 329891
reactant: 329879
is described by: http://identifiers.org/pubmed/11571294
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BAK1_on_BAX_using_Physical Interaction

329891
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAX

329879
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAX

meta Regulation of CASP3 on CASP10 using Proteolytic Processing
type: Reaction
modifier: 331247
product: 331235
reactant: 331223
is described by: http://identifiers.org/pubmed/9922454
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP10_using_Proteolytic Processing

331235
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP10

331223
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP10

meta Regulation of XIAP on CASP3 using Physical Interaction
type: Reaction
modifier: 334262
product: 334249
reactant: 334237
is described by: http://identifiers.org/pubmed/9990849
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_XIAP_on_CASP3_using_Physical Interaction

334249
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP3

334237
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP3

meta Regulation of TRADD on TRAF2 using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/8702708
name: Regulation_of_TRADD_on_TRAF2_using_Physical Interaction
product: 330617
fast: false
is described by: http://identifiers.org/pubmed/8565075
modifier: 330629
is: SBO:0000181
reactant: 330605
reversible: false
is described by: http://identifiers.org/pubmed/10892748

330617
type: SpeciesReference
stoichiometry: 1.0
species: meta Active TRAF2

330605
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive TRAF2

meta NonActive TRAF2
type: Species
is encoded by: http://identifiers.org/ncbigene/7186
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_TRAF2

meta Regulation of CASP9 on CASP3 using Proteolytic Processing
type: Reaction
modifier: 332479
product: 332467
reactant: 332455
is described by: http://identifiers.org/pubmed/9390557
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP9_on_CASP3_using_Proteolytic Processing

332467
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP3

332455
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP3

meta Regulation of BCL2L11 on MCL1 using Physical Interaction
type: Reaction
product: 329489
reversible: false
name: Regulation_of_BCL2L11_on_MCL1_using_Physical Interaction
modifier: 329501
fast: false
is: SBO:0000181
reactant: 329477
is described by: http://identifiers.org/pubmed/15694340
is described by: http://identifiers.org/pubmed/9731710

329489
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MCL1

329477
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MCL1

meta NonActive EIF2A
type: Species
is encoded by: http://identifiers.org/ncbigene/83939
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF2A

meta Regulation of CASP3 on EIF2S3 using Proteolytic Processing
type: Reaction
modifier: 333899
product: 333887
reactant: 333875
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF2S3_using_Proteolytic Processing

333887
type: SpeciesReference
stoichiometry: 1.0
species: meta Active EIF2S3

333875
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive EIF2S3

meta NonActive EIF2S3
type: Species
is encoded by: http://identifiers.org/ncbigene/1968
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_EIF2S3

meta Regulation of CASP3 on PARP1 using Proteolytic Processing
type: Reaction
modifier: 333061
product: 333049
reactant: 333037
is described by: http://identifiers.org/pubmed/7774019
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_PARP1_using_Proteolytic Processing

333049
type: SpeciesReference
stoichiometry: 1.0
species: meta Active PARP1

333037
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive PARP1

meta NonActive PARP1
type: Species
is encoded by: http://identifiers.org/ncbigene/142
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_PARP1

meta Regulation of BBC3 on BAX using Physical Interaction
type: Reaction
modifier: 331864
product: 331852
reactant: 331839
is described by: http://identifiers.org/pubmed/15574335
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BBC3_on_BAX_using_Physical Interaction

331852
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAX

331839
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAX

meta Regulation of SH3GLB1 on BAX using Physical Interaction
type: Reaction
reactant: 331766
is: SBO:0000181
reversible: false
is described by: http://identifiers.org/pubmed/11259440
name: Regulation_of_SH3GLB1_on_BAX_using_Physical Interaction
is described by: http://identifiers.org/pubmed/16227588
product: 331778
fast: false
modifier: 331790

331766
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAX

331778
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAX

meta NonActive BCL2L11
type: Species
is encoded by: http://identifiers.org/ncbigene/10018
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BCL2L11

meta Regulation of TRAF2 on IKK using Physical Interaction
type: Reaction
modifier: 330121
product: 330109
reactant: 330097
is described by: http://identifiers.org/pubmed/10795740
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_TRAF2_on_IKK_using_Physical Interaction

330109
type: SpeciesReference
stoichiometry: 1.0
species: meta Active IKK

330097
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive IKK

meta Regulation of MCL1 on BAK1 using Physical Interaction
type: Reaction
modifier: 329357
product: 329345
reactant: 329333
is described by: http://identifiers.org/pubmed/15901672
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_MCL1_on_BAK1_using_Physical Interaction

329345
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BAK1

329333
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BAK1

meta NonActive BCL2L2
type: Species
is encoded by: http://identifiers.org/ncbigene/599
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: NonActive_BCL2L2

meta Regulation of ATP on APAF1 using Physical Interaction
type: Reaction
modifier: 333827
product: 333815
reactant: 333803
is described by: http://identifiers.org/pubmed/9390557
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_ATP_on_APAF1_using_Physical Interaction

333815
type: SpeciesReference
stoichiometry: 1.0
species: meta Active APAF1

333803
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive APAF1

meta containment reaction PIDDosome
type: Reaction
product: 327613
reactant: 327601
reactant: 327589
reactant: 327577
fast: false
reversible: true
name: _containment

327613
type: SpeciesReference
stoichiometry: 1.0
species: meta Active PIDDosome

meta Active PIDDosome
type: Species
in compartment: meta SPIKE cell
has only substance units: false
has part: http://identifiers.org/ncbigene/8738
name: Active_
boundary condition: false
constant: false
has part: http://identifiers.org/ncbigene/835
has part: http://identifiers.org/ncbigene/55367
initial concentration: NaN
initial amount: NaN

327601
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP2

327589
type: SpeciesReference
stoichiometry: 1.0
species: meta Active LRDD

327577
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CRADD

meta Regulation of BAX on AIFM1 using Indirect
type: Reaction
modifier: 333427
product: 333415
reactant: 333403
is described by: http://identifiers.org/pubmed/12232790
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_BAX_on_AIFM1_using_Indirect

333415
type: SpeciesReference
stoichiometry: 1.0
species: meta Active AIFM1

333403
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive AIFM1

meta Regulation of CASP3 on CASP2 using Proteolytic Processing
type: Reaction
is: SBO:0000179
is described by: http://identifiers.org/pubmed/9261102
reversible: false
product: 329236
is described by: http://identifiers.org/pubmed/9922454
fast: false
name: Regulation_of_CASP3_on_CASP2_using_Proteolytic Processing
modifier: 329248
reactant: 329224

329236
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP2

329224
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP2

meta Regulation of BCL2L11 on BCL2L2 using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/9731710
is described by: http://identifiers.org/pubmed/9430630
name: Regulation_of_BCL2L11_on_BCL2L2_using_Physical Interaction
modifier: 330919
reversible: false
fast: false
reactant: 330895
is: SBO:0000181
product: 330907

330895
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2L2

330907
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2L2

meta Regulation of DAPK1 on MYL10 using Phosphorylation
type: Reaction
reversible: false
is described by: http://identifiers.org/pubmed/11485996
product: 334807
is described by: http://identifiers.org/pubmed/14600263
reactant: 334795
is: SBO:0000216
name: Regulation_of_DAPK1_on_MYL10_using_Phosphorylation
fast: false
modifier: 334819
is described by: http://identifiers.org/pubmed/15002035

334807
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL10

334795
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL10

meta Regulation of CASP9 on CASP7 using Proteolytic Processing
type: Reaction
product: 332940
reactant: 332928
is described by: http://identifiers.org/pubmed/9922454
is: SBO:0000179
modifier: 332952
fast: false
name: Regulation_of_CASP9_on_CASP7_using_Proteolytic Processing
reversible: false
is described by: http://identifiers.org/pubmed/17899380

332940
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP7

332928
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP7

meta Regulation of myosin II on membrane blebbing using Dephosphorylation
type: Reaction
modifier: 330447
product: 330435
reactant: 330423
is described by: http://identifiers.org/pubmed/9456322
is: SBO:0000330
fast: false
reversible: false
name: Regulation_of_myosin II_on_membrane blebbing_using_Dephosphorylation

330435
type: SpeciesReference
stoichiometry: 1.0
species: meta membrane blebbing

330423
type: SpeciesReference
stoichiometry: 1.0
species: meta membrane blebbing

meta Regulation of EIF4G2 on cap independent translation using Other
type: Reaction
modifier: 328224
product: 328211
reactant: 328198
is described by: http://identifiers.org/pubmed/10611228
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF4G2_on_cap-independent translation_using_Other

328211
type: SpeciesReference
stoichiometry: 1.0
species: meta cap independent translation

328198
type: SpeciesReference
stoichiometry: 1.0
species: meta cap independent translation

meta Regulation of EIF4EBP1 on protein translation using Other
type: Reaction
modifier: 328146
product: 328133
reactant: 328121
is described by: http://identifiers.org/pubmed/10672017
is: SBO:0000396
fast: false
reversible: false
name: Regulation_of_EIF4EBP1_on_protein translation_using_Other

328133
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

328121
type: SpeciesReference
stoichiometry: 1.0
species: meta protein translation

meta Regulation of CASP3 on ACIN1 using Proteolytic Processing
type: Reaction
modifier: 331682
product: 331670
reactant: 331658
is described by: http://identifiers.org/pubmed/10490026
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_ACIN1_using_Proteolytic Processing

331670
type: SpeciesReference
stoichiometry: 1.0
species: meta Active ACIN1

331658
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive ACIN1

meta Regulation of BAD on BCL2L2 using Physical Interaction
type: Reaction
modifier: 330809
product: 330797
reactant: 330785
is described by: http://identifiers.org/pubmed/10381646
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BAD_on_BCL2L2_using_Physical Interaction

330797
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2L2

330785
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2L2

meta Regulation of ROCK1 on MYL5 using Phosphorylation
type: Reaction
is described by: http://identifiers.org/pubmed/8702756
reversible: false
is described by: http://identifiers.org/pubmed/11283607
modifier: 334963
reactant: 334939
fast: false
name: Regulation_of_ROCK1_on_MYL5_using_Phosphorylation
product: 334951
is: SBO:0000216

334939
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive MYL5

334951
type: SpeciesReference
stoichiometry: 1.0
species: meta Active MYL5

meta Regulation of LRDD on CRADD using Physical Interaction
type: Reaction
modifier: 331393
product: 331380
reactant: 331368
is described by: http://identifiers.org/pubmed/15073321
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_LRDD_on_CRADD_using_Physical Interaction

331380
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CRADD

331368
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CRADD

meta Regulation of FAS on FADD using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/7538907
reactant: 329988
reversible: false
is described by: http://identifiers.org/pubmed/7536190
product: 330000
modifier: 330012
is described by: http://identifiers.org/pubmed/8967952
fast: false
name: Regulation_of_FAS_on_FADD_using_Physical Interaction
is: SBO:0000181

329988
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive FADD

330000
type: SpeciesReference
stoichiometry: 1.0
species: meta Active FADD

meta IkB
type: Species
initial amount: NaN
name: I-kappa-B
has part: http://identifiers.org/ncbigene/4793
initial concentration: NaN
has part: http://identifiers.org/ncbigene/4792
boundary condition: false
has part: http://identifiers.org/ncbigene/4794
has only substance units: false
in compartment: meta SPIKE cell
constant: false

meta Regulation of DFFA on DFFB using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/10527860
reversible: false
fast: false
is: SBO:0000181
reactant: 332201
is described by: http://identifiers.org/pubmed/10932250
product: 332213
name: Regulation_of_DFFA_on_DFFB_using_Physical Interaction
modifier: 332225

332201
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive DFFB

332213
type: SpeciesReference
stoichiometry: 1.0
species: meta Active DFFB

meta Regulation of BIRC5 on CASP7 using Physical Interaction
type: Reaction
modifier: 333609
product: 333597
reactant: 333585
is described by: http://identifiers.org/pubmed/11170436
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_BIRC5_on_CASP7_using_Physical Interaction

333597
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP7

333585
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP7

meta Regulation of TNFRSF10B on FADD using Physical Interaction
type: Reaction
product: 330255
is: SBO:0000181
name: Regulation_of_TNFRSF10B_on_FADD_using_Physical Interaction
is described by: http://identifiers.org/pubmed/15173180
reversible: false
fast: false
modifier: 330267
is described by: http://identifiers.org/pubmed/9430227
is described by: http://identifiers.org/pubmed/9430228
reactant: 330243

330255
type: SpeciesReference
stoichiometry: 1.0
species: meta Active FADD

330243
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive FADD

meta Regulation of CASP3 on EIF2A using Proteolytic Processing
type: Reaction
modifier: 328922
product: 328910
reactant: 328898
is described by: http://identifiers.org/pubmed/10734073
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_EIF2A_using_Proteolytic Processing

328910
type: SpeciesReference
stoichiometry: 1.0
species: meta Active EIF2A

328898
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive EIF2A

meta Regulation of TRAF2 on RIPK1 using Ubiquitination
type: Reaction
is described by: http://identifiers.org/pubmed/8702708
is described by: http://identifiers.org/pubmed/18981220
is described by: http://identifiers.org/pubmed/8612133
name: Regulation_of_TRAF2_on_RIPK1_using_Ubiquitination
fast: false
is: SBO:0000224
modifier: 331610
reactant: 331586
product: 331598
reversible: false

331586
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive RIPK1

331598
type: SpeciesReference
stoichiometry: 1.0
species: meta Active RIPK1

meta Regulation of RIPK1 on IKK using Physical Interaction
type: Reaction
modifier: 332697
product: 332685
reactant: 332673
is described by: http://identifiers.org/pubmed/12654725
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_RIPK1_on_IKK_using_Physical Interaction

332685
type: SpeciesReference
stoichiometry: 1.0
species: meta Active IKK

332673
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive IKK

meta Regulation of DYNLL1 on BCL2L11 using Physical Interaction
type: Reaction
is described by: http://identifiers.org/pubmed/10198631
reversible: false
product: 330870
is: SBO:0000181
name: Regulation_of_DYNLL1_on_BCL2L11_using_Physical Interaction
reactant: 330858
is described by: http://identifiers.org/pubmed/14561217
fast: false
modifier: 330882

330870
type: SpeciesReference
stoichiometry: 1.0
species: meta Active BCL2L11

330858
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive BCL2L11

meta Active MYL6
type: Species
is encoded by: http://identifiers.org/ncbigene/4637
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: meta SPIKE cell
name: Active_MYL6

meta Regulation of CASP3 on CASP7 using Proteolytic Processing
type: Reaction
modifier: 329465
product: 329453
reactant: 329441
is described by: http://identifiers.org/pubmed/17899380
is: SBO:0000179
fast: false
reversible: false
name: Regulation_of_CASP3_on_CASP7_using_Proteolytic Processing

329453
type: SpeciesReference
stoichiometry: 1.0
species: meta Active CASP7

329441
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive CASP7

meta Regulation of CASP2 on TRAF2 using Physical Interaction
type: Reaction
modifier: 331538
product: 331526
reactant: 331514
is described by: http://identifiers.org/pubmed/15590671
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_CASP2_on_TRAF2_using_Physical Interaction

331526
type: SpeciesReference
stoichiometry: 1.0
species: meta Active TRAF2

331514
type: SpeciesReference
stoichiometry: 1.0
species: meta NonActive TRAF2

meta containment reaction myosin II
type: Reaction
product: 327565
fast: false
reversible: true
name: myosin II_containment

327565
type: SpeciesReference
stoichiometry: 1.0
species: meta Active myosin II

meta Regulation of PMAIP1 on BAX using Physical Interaction
type: Reaction
modifier: 331754
product: 331742
reactant: 331730
is described by: http://identifiers.org/pubmed/15705586
is: SBO:0000181
fast: false
reversible: false
name: Regulation_of_PMAIP1_on_BAX_using_Physical Interaction

331742
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331730
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meta Active HRK
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meta Regulation of CASP10 on CASP3 using Proteolytic Processing
type: Reaction
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334164
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334176
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meta Regulation of BID on BCL2L2 using Physical Interaction
type: Reaction
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name: Regulation_of_BID_on_BCL2L2_using_Physical Interaction

330761
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species: meta Active BCL2L2

330749
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meta Regulation of RPS6KA1 on BAD using Phosphorylation
type: Reaction
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name: Regulation_of_RPS6KA1_on_BAD_using_Phosphorylation

333778
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species: meta Active BAD

333766
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meta Regulation of BCL2L11 on BAX using Other
type: Reaction
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is described by: http://identifiers.org/pubmed/15721256

329381
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329369
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meta Regulation of ROCK1 on DAPK3 using Phosphorylation
type: Reaction
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333012
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333000
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meta Regulation of CRADD on RIPK1 using Physical Interaction
type: Reaction
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name: Regulation_of_CRADD_on_RIPK1_using_Physical Interaction

331417
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species: meta Active RIPK1

331405
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meta Regulation of BBC3 on BCL2L2 using Physical Interaction
type: Reaction
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name: Regulation_of_BBC3_on_BCL2L2_using_Physical Interaction

330833
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species: meta Active BCL2L2

330821
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meta Regulation of TRADD on RIPK1 using Physical Interaction
type: Reaction
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name: Regulation_of_TRADD_on_RIPK1_using_Physical Interaction

331634
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331622
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meta Regulation of TNFRSF10B on TRADD using Physical Interaction
type: Reaction
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product: 328727
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reactant: 328715
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328727
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328715
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meta Regulation of BIRC6 on DIABLO using Ubiquitination
type: Reaction
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reactant: 329625
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name: Regulation_of_BIRC6_on_DIABLO_using_Ubiquitination

329637
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species: meta Active DIABLO

329625
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species: meta NonActive DIABLO

meta Regulation of EIF4G3 on protein translation using Other
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product: 328023
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modifier: 328035
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reactant: 328011

328023
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328011
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species: meta protein translation

meta Regulation of CASP7 on PARP1 using Proteolytic Processing
type: Reaction
modifier: 329575
product: 329562
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is: SBO:0000179
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name: Regulation_of_CASP7_on_PARP1_using_Proteolytic Processing

329562
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species: meta Active PARP1

329550
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species: meta NonActive PARP1

meta Regulation of BIRC6 on CASP7 using Physical Interaction
type: Reaction
modifier: 329831
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name: Regulation_of_BIRC6_on_CASP7_using_Physical Interaction

329819
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species: meta Active CASP7

329807
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species: meta NonActive CASP7

meta IAP fam
type: Species
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meta Regulation of BCL2 on BAK1 using Physical Interaction
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331089
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331077
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meta Regulation of ROCK1 on MYL10 using Phosphorylation
type: Reaction
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reactant: 334975
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product: 334987
name: Regulation_of_ROCK1_on_MYL10_using_Phosphorylation

334975
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species: meta NonActive MYL10

334987
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species: meta Active MYL10

meta Regulation of DIABLO on BIRC6 using Physical Interaction
type: Reaction
modifier: 328448
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name: Regulation_of_DIABLO_on_BIRC6_using_Physical Interaction

328436
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species: meta Active BIRC6

328424
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meta Regulation of CASP3 on BIRC6 using Proteolytic Processing
type: Reaction
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modifier: 329759
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name: Regulation_of_CASP3_on_BIRC6_using_Proteolytic Processing

329734
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329747
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meta Regulation of TNF on TNFRSF1A using Physical Interaction
type: Reaction
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product: 330653
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reactant: 330641
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modifier: 330665

330653
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species: meta Active TNFRSF1A

330641
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meta Regulation of MYL10 on myosin II using Other
type: Reaction
modifier: 334443
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name: Regulation_of_MYL10_on_myosin II_using_Other

334431
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species: meta Active myosin II

334419
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meta Regulation of BIRC2 on CASP3 using Physical Interaction
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name: Regulation_of_BIRC2_on_CASP3_using_Physical Interaction
reactant: 330713
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modifier: 330737
product: 330725
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330713
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330725
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meta Regulation of XIAP on CASP7 using Physical Interaction
type: Reaction
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reactant: 329843
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product: 329855
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is described by: http://identifiers.org/pubmed/11359776

329843
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329855
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meta Regulation of BIRC6 on CASP3 using Physical Interaction
type: Reaction
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name: Regulation_of_BIRC6_on_CASP3_using_Physical Interaction

329273
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329260
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meta Regulation of ENDOG on DNA fragmentation using Other
type: Reaction
modifier: 332116
product: 332104
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name: Regulation_of_ENDOG_on_DNA fragmentation_using_Other

332104
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species: meta DNA fragmentation

332092
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meta Regulation of BAK1 on HTRA2 using Indirect
type: Reaction
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name: Regulation_of_BAK1_on_HTRA2_using_Indirect

330363
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species: meta Active HTRA2

330351
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meta Regulation of CASP3 on EIF4EBP1 using Proteolytic Processing
type: Reaction
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name: Regulation_of_CASP3_on_EIF4EBP1_using_Proteolytic Processing

333121
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species: meta Active EIF4EBP1

333109
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species: meta NonActive EIF4EBP1

meta Regulation of FADD on CASP10 using Physical Interaction
type: Reaction
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name: Regulation_of_FADD_on_CASP10_using_Physical Interaction

333378
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species: meta Active CASP10

333366
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meta Regulation of CASP3 on EIF4B using Proteolytic Processing
type: Reaction
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name: Regulation_of_CASP3_on_EIF4B_using_Proteolytic Processing

328508
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328496
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meta Regulation of XIAP on CASP3 using Ubiquitination
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reactant: 328751
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product: 328763
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modifier: 328775

328751
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328763
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meta Regulation of DIABLO on XIAP using Physical Interaction
type: Reaction
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332576
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332564
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meta Regulation of BIRC3 on CASP7 using Physical Interaction
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328654
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328642
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