R04740MM (S)-3-Hydroxytetradecanoyl-CoA-->trans-Tetradec-2-enoyl-CoA+H2O
Transporter77 Unknown carrier - Glutathione
C16254MM [Dihydrolipoyllysine-residue succinyltransferase]
R03316MM 3-Carboxy-1-hydroxypropyl-ThPP+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residuesuccinyltransferase]S-succinyldihydrolipoyllysine+Thiamindiphosphate
R00551MM L-Arginine+H2O-->L-Ornithine+Urea
C05378Cyto beta-D-Fructose 1,6-bisphosphate
C05125MM 2-(alpha-Hydroxyethyl)thiamine diphosphate
R01279MM Palmitoyl-CoA+FAD-->trans-Hexadec-2-enoyl-CoA+FADH2
Transporter42 deoxynucleotide carrier - CDP for ATP
C00671MM (S)-3-Methyl-2-oxopentanoic acid
R07603MM (S)-3-Methyl-2-oxopentanoicacid+Thiamindiphosphate-->2-Methyl-1-hydroxybutyl-ThPP+CO2
Transporter5 Citrate carrier - Citrate for Isocitrate
R03165Cyto Hydroxymethylbilane-->UroporphyrinogenIII+H2O
R04967MM Tetradecanoyl-[acp]+NADP+-->trans-Tetradec-2-enoyl-[acp]+NADPH+H+
R03197Cyto UroporphyrinogenIII-->CoproporphyrinogenIII+4CO2
C05223MM Dodecanoyl-[acyl-carrier protein]
R01786Cyto ATP+alpha-D-Glucose-->ADP+alpha-D-Glucose6-phosphate
C04076MM L-2-Aminoadipate 6-semialdehyde
Transporter64 Unknown amino acid carrier - L-Asparagine
R00833MM (R)-2-Methyl-3-oxopropanoyl-CoA-->Succinyl-CoA
R00851MM sn-Glycerol3-phosphate+Palmitoyl-CoA-->1-Acyl-sn-glycerol3-phosphate+CoA
Transporter13 Dicarboxylate carrier - Malate for thiosulfate
Transporter14 Dicarboxylate carrier - Succinate for sulphite
R02241MM Phosphatidate+CoA-->1-Acyl-sn-glycerol3-phosphate+Palmitoyl-CoA
Transporter78 Unknown carrier - 5-Aminolevulinate
R04742MM Decanoyl-CoA+Acetyl-CoA-->CoA+3-Oxododecanoyl-CoA
R01923MM Palmitoyl-CoA+L-Carnitine-->CoA+L-Palmitoylcarnitine
R00115MM 2Glutathione+NADP+-->Glutathionedisulfide+NADPH+H+
R02765MM (R)-Methylmalonyl-CoA --> (S)-Methylmalonyl-CoA
Transporter30 Glutamate carrier - Glutamate and H+
R00351MM Citrate+CoA-->Acetyl-CoA+H2O+Oxaloacetate
C04619MM (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
R00245MM L-Glutamate5-semialdehyde+NAD++H2O-->L-Glutamate+NADH+H+
R03990MM Tetradecanoyl-CoA+FAD-->trans-Tetradec-2-enoyl-CoA+FADH2
R07618MM EnzymeN6-(dihydrolipoyl)lysine+NAD+-->EnzymeN6-(lipoyl)lysine+NADH+H+
C15973MM Enzyme N6-(dihydrolipoyl)lysine
R04968MM Tetradecanoyl-[acp]+Malonyl-[acyl-carrierprotein]-->3-Oxohexadecanoyl-[acp]+CO2+Acyl-carrierprotein
R03172MM (S)-2-Methylbutanoyl-CoA+FAD-->2-Methylbut-2-enoyl-CoA+FADH2
C04620MM (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
R04536MM (3R)-3-Hydroxyoctanoyl-[acyl-carrierprotein]+NADP+-->3-Oxooctanoyl-[acp]+NADPH+H+
Transporter65 Unknown amino acid carrier - L-Cysteine
C16255MM [Dihydrolipoyllysine-residue acetyltransferase]
R01699MM Pyruvate+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residueacetyltransferase]S-acetyldihydrolipoyllysine+CO2
R01700MM 2-Oxoglutarate+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residuesuccinyltransferase]S-succinyldihydrolipoyllysine+CO2
R00214Cyto (S)-Malate+NAD+-->Pyruvate+CO2+NADH+H+
R00342Cyto (S)-Malate+NAD+-->Oxaloacetate+NADH+H+
Transporter15 Dicarboxylate carrier - Succinate for sulfate
R00710MM Acetaldehyde+NAD++H2O-->Acetate+NADH+H+
R07601MM 4-Methyl-2-oxopentanoate+Thiamindiphosphate-->3-Methyl-1-hydroxybutyl-ThPP+CO2
Transporter2 Citrate carrier - Malate for isocitrate
Transporter74 Unknown amino acid carrier - L-Isoleucine
R01138MM dATP+Pyruvate-->dADP+Phosphoenolpyruvate
C00236Cyto 3-Phospho-D-glyceroyl phosphate
R01512Cyto ATP+3-Phospho-D-glycerate-->ADP+3-Phospho-D-glyceroylphosphate
Transporter24 Ornithine carrier - Lysine for arginine and H+
R04754MM Decanoyl-CoA+FAD-->trans-Dec-2-enoyl-CoA+FADH2
R00256MM L-Glutamine+H2O-->L-Glutamate+NH3
R02163MM COMPLEX_I_Ubiquinone+NADH-->Ubiquinol+NAD+4H+0.002O2.-
R01899MM Isocitrate+NADP+-->Oxalosuccinate+NADPH+H+
R00239MM ATP+L-Glutamate-->ADP+L-Glutamyl5-phosphate
R03313MM L-Glutamate5-semialdehyde+Orthophosphate+NADP+-->L-Glutamyl5-phosphate+NADPH+H+
R03314MM L-Glutamate5-semialdehyde-->(S)-1-Pyrroline-5-carboxylate+H2O
Transporter40 deoxynucleotide carrier - GDP for ATP
C15979MM [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]
R03174MM (S)-2-Methylbutanoyl-CoA+EnzymeN6-(dihydrolipoyl)lysine-->CoA+[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(2-methylbutanoyl)dihydrolipoyllysine
R02685MM (3S)-3-Hydroxyacyl-CoA-->trans-2,3-Dehydroacyl-CoA+H2O
Transporter27 Ornithine carrier - L-Arginine for H+
C04405MM (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
R00342MM (S)-Malate+NAD+-->Oxaloacetate+NADH+H+
C15977MM [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]
R01701MM 3-Methyl-2-oxobutanoicacid+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(2-methylpropanoyl)dihydrolipoyllysine+CO2
C15975MM [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]
R01278MM Palmitoyl-CoA+NADP+-->trans-Hexadec-2-enoyl-CoA+NADPH+H+
R07602MM 3-Methyl-1-hydroxybutyl-ThPP+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(3-methylbutanoyl)dihydrolipoyllysine+Thiamindiphosphate
R03777MM Octanoyl-CoA+FAD-->trans-Oct-2-enoyl-CoA+FADH2
R04965MM (R)-3-Hydroxydodecanoyl-[acp]-->trans-Dodec-2-enoyl-[acp]+H2O
R04534MM (3R)-3-Hydroxydecanoyl-[acyl-carrierprotein]+NADP+-->3-Oxodecanoyl-[acp]+NADPH
Transporter25 Ornithine carrier - L-Lysine for H+
R00830MM Succinyl-CoA+Glycine-->5-Aminolevulinate+CoA+CO2
R00727MM ITP+Succinate+CoA-->IDP+Orthophosphate+Succinyl-CoA
Transporter12 Dicarboxylate carrier - Malate for sulfate
R02199MM L-Isoleucine+2-Oxoglutarate-->(S)-3-Methyl-2-oxopentanoicacid+L-Glutamate
R04741MM (S)-3-Hydroxydodecanoyl-CoA+NAD+-->3-Oxododecanoyl-CoA+NADH+H+
R00243MM L-Glutamate+NAD++H2O-->2-Oxoglutarate+NH3+NADH+H+
Transporter41 deoxynucleotide carrier - UDP for ATP
R00094MM 2Glutathione+NAD+-->Glutathionedisulfide+NADH+H+
Transporter28 Ornithine carrier - L-Citrulline for H+
Transporter29 Graves disease carrier - CoA
R04964MM (R)-3-Hydroxydodecanoyl-[acp]+NADP+-->3-Oxododecanoyl-[acp]+NADPH+H+
R00344MM ATP+Pyruvate+HCO3--->ADP+Orthophosphate+Oxaloacetate
R04751MM Hexanoyl-CoA+FAD-->trans-Hex-2-enoyl-CoA+FADH2
R03989MM Tetradecanoyl-CoA+NADP+-->trans-Tetradec-2-enoyl-CoA+NADPH+H+
Transporter50 Unknown pyruvate carrier - Pyruvate
R03270MM 2-(alpha-Hydroxyethyl)thiaminediphosphate+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residueacetyltransferase]S-acetyldihydrolipoyllysine+Thiamindiphosphate
Transporter37 deoxynucleotide carrier - dCDP for ATP
R00431MM GTP+Oxaloacetate-->GDP+Phosphoenolpyruvate+CO2
C04633MM (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
R04535MM (3R)-3-Hydroxydecanoyl-[acyl-carrierprotein]-->trans-Dec-2-enoyl-[acp]+H2O
R01655MM 5,10-Methenyltetrahydrofolate+H2O-->10-Formyltetrahydrofolate+H+
R00200Cyto ATP+Pyruvate-->ADP+Phosphoenolpyruvate
R01251MM L-Proline+NADP+-->(S)-1-Pyrroline-5-carboxylate+NADPH+H+
R00709MM Isocitrate+NAD+-->2-Oxoglutarate+CO2+NADH+H+
R07600MM 2-Methyl-1-hydroxypropyl-ThPP+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(2-methylpropanoyl)dihydrolipoyllysine+Thiamindiphosphate
Transporter1 Citrate carrier - Malate for citrate
R04737MM (S)-3-Hydroxyhexadecanoyl-CoA+NAD+-->3-Oxopalmitoyl-CoA+NADH+H+
Transporter73 Unknown amino acid carrier - Glycine
R01923Cyto Palmitoyl-CoA+L-Carnitine-->CoA+L-Palmitoylcarnitine
R01090MM L-Leucine+2-Oxoglutarate-->4-Methyl-2-oxopentanoate+L-Glutamate
R00941MM 10-Formyltetrahydrofolate+NADP++H2O-->Tetrahydrofolate+CO2+NADPH+H+
R00004MM Pyrophosphate+H2O-->2Orthophosphate
Transporter22 Ornithine carrier - Ornithine for lysine and H+
Transporter23 Ornithine carrier - Ornithine for arginine and H+
C06157MM [Dihydrolipoyllysine-residue succinyltransferase]
R02571MM Glutaryl-CoA+Dihydrolipoamide-->CoA+S-Glutaryldihydrolipoamide
R00740MM 3-Oxopropanoate+CoA+NADP+-->Malonyl-CoA+NADPH+H+
R02660MM 22-Methylpropanoyl-CoA+Oxygen-->22-Methylprop-2-enoyl-CoA+2H2O
R04753MM Decanoyl-CoA+NADP+-->trans-Dec-2-enoyl-CoA+NADPH+H+
Transporter10 Dicarboxylate carrier - Succinate for phosphate
R04739MM (S)-3-Hydroxytetradecanoyl-CoA+NAD+-->3-Oxotetradecanoyl-CoA+NADH
R00238MM 2Acetyl-CoA-->CoA+Acetoacetyl-CoA
Transporter39 deoxynucleotide carrier - ADP for ATP
R00081MM COMPLEX_IV_Oxygen+4Ferrocytochromec-->4Ferricytochromec+2H2O
R00432MM GTP+Succinate+CoA-->GDP+Orthophosphate+Succinyl-CoA
Transporter26 Ornithine carrier - L-Ornithine for H+
R00316MM ATP+Acetate-->Pyrophosphate+Acetyladenylate
R04962MM Decanoyl-[acp]+NADP+-->trans-Dec-2-enoyl-[acp]+NADPH+H+
R01253MM L-Proline+FAD-->(S)-1-Pyrroline-5-carboxylate+FADH2
R03857MM Lauroyl-CoA+FAD-->2-trans-Dodecenoyl-CoA+FADH2
R00705MM 3-Oxopropanoate+CoA+NAD+-->Acetyl-CoA+CO2+NADH+H+
R03776MM Octanoyl-CoA+NADP+-->trans-Oct-2-enoyl-CoA+NADPH+H+
Transporter75 Unknown amino acid carrier - L-Leucine
R01858MM dGTP+Pyruvate-->dGDP+Phosphoenolpyruvate
R01859MM ATP+Propanoyl-CoA+HCO3--->ADP+Orthophosphate+(S)-2-Methyl-3-oxopropanoyl-CoA
R04433MM Ubiquinone+FADH2-->Ubiquinol+FAD+
C04618MM (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
R04533MM (3R)-3-Hydroxybutanoyl-[acyl-carrierprotein]+NADP+-->Acetoacetyl-[acp]+NADPH+H+
Transporter62 Diffusion? - Butanoic acid
R01626MM Malonyl-CoA+Acyl-carrierprotein-->CoA+Malonyl-[acyl-carrierprotein]
R00742MM ATP+Acetyl-CoA+HCO3--->ADP+Orthophosphate+Malonyl-CoA
R02661MM 2-Methylpropanoyl-CoA+FAD-->2-Methylprop-2-enoyl-CoA+FADH2
R00084Cyto 4Porphobilinogen+H2O-->Hydroxymethylbilane+4NH3
R00726MM ITP+Oxaloacetate-->IDP+Phosphoenolpyruvate+CO2
Transporter11 Dicarboxylate carrier - Malate for sulphite
C04688MM (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
R00086MM ATP_SYNTHASE_ADP+Orthophosphate+4H+-->ATP+H2O
R00945MM 5,10-Methylenetetrahydrofolate+Glycine+H2O-->Tetrahydrofolate+L-Serine
Transporter67 Unknown amino acid carrier - L-Proline
R00927MM Propanoyl-CoA+Acetyl-CoA-->CoA+2-Methylacetoacetyl-CoA
R04963MM Decanoyl-[acp]+Malonyl-[acyl-carrierprotein]-->3-Oxododecanoyl-[acp]+CO2+Acyl-carrierprotein
R04749MM (S)-Hydroxyhexanoyl-CoA-->trans-Hex-2-enoyl-CoA+H2O
C00356MM (S)-3-Hydroxy-3-methylglutaryl-CoA
R02085MM (S)-3-Hydroxy-3-methylglutaryl-CoA-->3-Methylglutaconyl-CoA+H2O
R03858MM Lauroyl-CoA+Acetyl-CoA-->CoA+3-Oxotetradecanoyl-CoA
Transporter49 oxodicarboxylate carrier - oxaloacetate for oxoglutarate
R00706MM 3-Oxopropanoate+CoA+NADP+-->Acetyl-CoA+CO2+NADPH+H+
R00216MM (S)-Malate+NADP+-->Pyruvate+CO2+NADPH+H+
R00707MM (S)-1-Pyrroline-5-carboxylate+NAD++2H2O-->L-Glutamate+NADH+H+
R03222MM 2ProtoporphyrinogenIX+3Oxygen-->2Protoporphyrin+6H2O
Transporter36 deoxynucleotide carrier - dGDP for ATP
R07162MM Acyl-CoA+NADP+-->trans-2,3-Dehydroacyl-CoA+NADPH+H+
R00410MM Succinyl-CoA+Acetoacetate-->Succinate+Acetoacetyl-CoA
R00430MM GTP+Pyruvate-->GDP+Phosphoenolpyruvate
R01280Cyto ATP+Hexadecanoicacid+CoA-->AMP+Palmitoyl-CoA+Pyrophosphate
R01648MM 4-Aminobutanoate+2-Oxoglutarate-->Succinatesemialdehyde+L-Glutamate
R04204MM (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA-->2-Methylbut-2-enoyl-CoA+H2O
R00724MM ITP+Pyruvate-->IDP+Phosphoenolpyruvate
R04097MM 3-Methylbutanoyl-CoA+EnzymeN6-(dihydrolipoyl)lysine-->CoA+[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(3-methylbutanoyl)dihydrolipoyllysine
R01248MM L-Proline+NAD+-->(S)-1-Pyrroline-5-carboxylate+NADH+H+
R07599MM 3-Methyl-2-oxobutanoicacid+Thiamindiphosphate-->2-Methyl-1-hydroxypropyl-ThPP+CO2
Transporter7 ADP/ATP carrier - ADP for ATP
R04726MM Dodecanoyl-[acyl-carrierprotein]+Malonyl-[acyl-carrierprotein]-->3-Oxotetradecanoyl-[acp]+CO2+Acyl-carrierprotein
Transporter72 Unknown amino acid carrier - L-Tryptophan
Transporter60 Phosphatidylethanolamine carrier - Phosphatidylethanolamine
C06002MM (S)-Methylmalonate semialdehyde
R00935MM (S)-Methylmalonatesemialdehyde+CoA+NAD+-->Propanoyl-CoA+CO2+NADH+H+
R04430MM Butyryl-[acp]+NADP+-->But-2-enoyl-[acyl-carrierprotein]+NADPH+H+
C04246MM But-2-enoyl-[acyl-carrier protein]
Transporter21 Ornithine carrier - Arginine for citrulline and H+
R02161MM COMPLEX_III_Ubiquinol+2Ferricytochromec-->Ubiquinone+2Ferrocytochromec
Transporter9 Dicarboxylate carrier - Malate for phosphate
R04738MM (S)-3-Hydroxyhexadecanoyl-CoA-->trans-Hexadec-2-enoyl-CoA+H2O
R00236MM Acetyladenylate+CoA-->AMP+Acetyl-CoA
R01214MM L-Valine+2-Oxoglutarate-->3-Methyl-2-oxobutanoicacid+L-Glutamate
R01175MM Butanoyl-CoA+FAD-->FADH2+Crotonoyl-CoA
Transporter38 deoxynucleotide carrier - dTDP for ATP
R04960MM Octanoyl-[acp]+Malonyl-[acyl-carrierprotein]-->3-Oxodecanoyl-[acp]+CO2+Acyl-carrierprotein
R04224MM 2-Methylprop-2-enoyl-CoA+H2O-->(S)-3-Hydroxyisobutyryl-CoA
R04746MM (S)-Hydroxyoctanoyl-CoA-->trans-Oct-2-enoyl-CoA+H2O
R04747MM Hexanoyl-CoA+Acetyl-CoA-->CoA+3-Oxooctanoyl-CoA
R03856MM Lauroyl-CoA+NADP+-->2-trans-Dodecenoyl-CoA+NADPH+H+
Transporter46 oxodicarboxylate carrier - Oxoadipate for oxoglutarate
Transporter47 oxodicarboxylate carrier - 2-aminoadipate for oxoglutarate
R00667MM L-Ornithine+2-Oxoglutarate-->L-Glutamate5-semialdehyde+L-Glutamate
Transporter34 deoxynucleotide carrier - dTTP for ATP
R00405MM ATP+Succinate+CoA-->ADP+Orthophosphate+Succinyl-CoA
R01070Cyto beta-D-Fructose1,6-bisphosphate-->Glyceronephosphate+D-Glyceraldehyde3-phosphate
R01624MM Acetyl-CoA+Acyl-carrierprotein-->CoA+Acetyl-[acyl-carrierprotein]
R00036Cyto 25-Aminolevulinate-->Porphobilinogen+2H2O
Transporter82 Unknown carrier - Acetoacetate
R01218MM 5,10-Methylenetetrahydrofolate+NAD+-->5,10-Methenyltetrahydrofolate+NADH+H+
R01220MM 5,10-Methylenetetrahydrofolate+NADP+-->5,10-Methenyltetrahydrofolate+NADPH+H+
Transporter70 Unknown amino acid carrier - L-Methionine
R01176MM ATP+Butanoicacid+CoA-->AMP+Pyrophosphate+Butanoyl-CoA
R04568MM (3R)-3-Hydroxytetradecanoyl-[acyl-carrierprotein]-->trans-Tetradec-2-enoyl-[acp]+H2O
R03170MM 2(S)-2-Methylbutanoyl-CoA+Oxygen-->22-Methylbut-2-enoyl-CoA+2H2O
R00926MM Propinoladenylate+CoA-->AMP+Propanoyl-CoA
R02529MM Aminoacetone+H2O+Oxygen-->Methylglyoxal+NH3+H2O2
R02569MM Acetyl-CoA+EnzymeN6-(dihydrolipoyl)lysine-->CoA+[Dihydrolipoyllysine-residueacetyltransferase]S-acetyldihydrolipoyllysine
Transporter19 Ornithine carrier - Ornithine for citrulline and H+
Transporter20 Ornithine carrier - Lysine for citrulline and H+
R04748MM (S)-Hydroxyhexanoyl-CoA+NAD+-->3-Oxohexanoyl-CoA+NADH+H+
R00261MM L-Glutamate-->4-Aminobutanoate+CO2
R02030MM Phosphatidylglycerol+CDP-diacylglycerol-->Cardiolipin+CMP
Transporter48 oxodicarboxylate carrier - citrate for oxoglutarate
R04957MM Hexanoyl-[acp]+Malonyl-[acyl-carrierprotein]-->3-Oxooctanoyl-[acp]+CO2+Acyl-carrierprotein
R04203MM (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA+NAD+-->2-Methylacetoacetyl-CoA+NADH+H+
R07390MM 2Phosphatidylglycerol-->Cardiolipin+Glycerol
Transporter6 Phosphate carrier - Phosphate and H+ together
R00621MM 2-Oxoglutarate+Thiamindiphosphate-->3-Carboxy-1-hydroxypropyl-ThPP+CO2
R02029MM Phosphatidylglycerophosphate+H2O-->Phosphatidylglycerol+Orthophosphate
R04725MM Dodecanoyl-[acyl-carrierprotein]+NADP+-->trans-Dodec-2-enoyl-[acp]+NADPH+H+
R04779Cyto ATP+beta-D-Fructose6-phosphate-->ADP+beta-D-Fructose1,6-bisphosphate
Transporter71 Unknown amino acid carrier - L-Phenylalanine
R01799MM CTP+Phosphatidate-->Pyrophosphate+CDP-diacylglycerol
R01801MM CDP-diacylglycerol+sn-Glycerol3-phosphate-->CMP+Phosphatidylglycerophosphate
Transporter59 Phosphatidylcholine carrier - Phosphatidylcholine
R04355MM Acetyl-[acyl-carrierprotein]+Malonyl-[acyl-carrierprotein]-->Acetoacetyl-[acp]+CO2+Acyl-carrierprotein
R04428MM (3R)-3-Hydroxybutanoyl-[acyl-carrierprotein]-->But-2-enoyl-[acyl-carrierprotein]+H2O
R02570MM Succinyl-CoA+EnzymeN6-(dihydrolipoyl)lysine-->CoA+[Dihydrolipoyllysine-residuesuccinyltransferase]S-succinyldihydrolipoyllysine
R01360MM (S)-3-Hydroxy-3-methylglutaryl-CoA-->Acetyl-CoA+Acetoacetate
R00658Cyto 2-Phospho-D-glycerate-->Phosphoenolpyruvate+H2O
R00274MM H2O2+2Glutathione-->Glutathionedisulfide+2H2O
R08657MM sn-Glycerol 3-phosphate+Ubiquinone-->Glyceronephosphate+Ubiquinol
R04744MM (S)-Hydroxydecanoyl-CoA-->trans-Dec-2-enoyl-CoA+H2O
Transporter76 Unknown amino acid carrier - L-Valine
R01171MM Butanoyl-CoA+NAD+-->Crotonoyl-CoA+NADH+H+
R03103MM L-2-Aminoadipate6-semialdehyde+NADP++H2O-->L-2-Aminoadipate+NADPH+H+
R04959MM Octanoyl-[acp]+NADP+-->trans-Oct-2-enoyl-[acp]+NADPH+H+
Transporter17 Oxoglutarate carrier - Oxoglutarate for malate
Transporter58 Phosphatidylserine carrier - Phosphatidylserine
R01354MM ATP+Propanoate-->Pyrophosphate+Propinoladenylate
R03778MM Octanoyl-CoA+Acetyl-CoA-->CoA+3-Oxodecanoyl-CoA
R00659MM UTP+Pyruvate-->UDP+Phosphoenolpyruvate
This model is from the article: A metabolic model of the mitochondrion and its use in modelling diseases of the tricarboxylic acid cycle. Smith AC, Robinson AJ. BMC Syst Biol. 2011 Jun 29;5(1):102. 21714867 , Abstract: BACKGROUND:Mitochondria are a vital component of eukaryotic cells and their dysfunction is implicated in a large number of metabolic, degenerative and age-related human diseases. The mechanism or these disorders can be difficult to elucidate due to the inherent complexity of mitochondrial metabolism. To understand how mitochondrial metabolic dysfunction contributes to these diseases, a metabolic model of a human heart mitochondrion was created. RESULTS: A new model of mitochondrial metabolism was built on the principle of metabolite availability using MitoMiner, a mitochondrial proteomics database, to evaluate the subcellular localisation of reactions that have evidence for mitochondrial localisation. Extensive curation and manual refinement was used to create a model called iAS253, containing 253 reactions, 245 metabolites and 89 transport steps across the inner mitochondrial membrane. To demonstrate the predictive abilities of the model, flux balance analysis was used to calculate metabolite fluxes under normal conditions and to simulate three metabolic disorders that affect the TCA cycle: fumarase deficiency, succinate dehydrogenase deficiency and alpha-ketoglutarate dehydrogenase deficiency. CONCLUSION: The results of simulations using the new model corresponded closely with phenotypic data under normal conditions and provided insight into the complicated and unintuitive phenotypes of the three disorders, including the effect of interventions that may be of therapeutic benefit, such as low glucose diets or amino acid supplements. The model offers the ability to investigate other mitochondrial disorders and can provide the framework for the integration of experimental data in future studies. Created by Anthony C. Smith (Mon Mar 14 11:03:11 2011) MRC - Mitochondrial Biology Unit, Cambridge, UK. acs@mrc-mbu.cam.ac.uk This metabolic network is a stocihiometric model of a human heart mitochondrion. Identifiers are KEGG Ids. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
R05064MM (S)-3-Hydroxyisobutyryl-CoA+H2O-->CoA+(S)-3-Hydroxyisobutyrate
R00391MM Acyl-CoA+Acetyl-CoA-->CoA+3-Oxoacyl-CoA
R01015Cyto D-Glyceraldehyde3-phosphate-->Glyceronephosphate
R01061Cyto D-Glyceraldehyde3-phosphate+Orthophosphate+NAD+-->3-Phospho-D-glyceroylphosphate+NADH+H+
R01361MM (R)-3-Hydroxybutanoate+NAD+-->Acetoacetate+NADH+H+
R04138MM ATP+3-Methylcrotonyl-CoA+HCO3--->ADP+Orthophosphate+3-Methylglutaconyl-CoA
R00004Cyto Pyrophosphate+H2O-->2Orthophosphate
R03991MM Tetradecanoyl-CoA+Acetyl-CoA-->CoA+3-Oxopalmitoyl-CoA
Transporter16 Dicarboxylate carrier - Succinate for thiosulfate
R00713MM Succinatesemialdehyde+NAD++H2O-->Succinate+NADH+H+
Transporter81 Unknown carrier - Fumarate
R00708MM (S)-1-Pyrroline-5-carboxylate+NADP++2H2O-->L-Glutamate+NADPH+H+
R04745MM (S)-Hydroxyoctanoyl-CoA+NAD+-->3-Oxooctanoyl-CoA+NADH+H+
Transporter4 Citrate carrier - PEP for isocitrate
R01978MM (S)-3-Hydroxy-3-methylglutaryl-CoA+CoA-->Acetyl-CoA+H2O+Acetoacetyl-CoA
Transporter69 Unknown amino acid carrier - L-Histidine
C00449MM N6-(L-1,3-Dicarboxypropyl)-L-lysine
R04566MM (3R)-3-Hydroxytetradecanoyl-[acyl-carrierprotein]+NADP+-->3-Oxotetradecanoyl-[acp]+NADPH+H+
R03105MM Mercaptopyruvate+Sulfite-->Thiosulfate+Pyruvate
R01706MM Hexadecanoyl-[acp]+H2O-->Acyl-carrierprotein+Hexadecanoicacid
Transporter33 deoxynucleotide carrier - dCTP for ATP
R00703Cyto (S)-Lactate+NAD+-->Pyruvate+NADH+H+
R02487MM Glutaryl-CoA+FAD-->FADH2+Crotonoyl-CoA+CO2
R00388MM Acyl-CoA+Oxygen-->trans-2,3-Dehydroacyl-CoA+H2O2
Transporter18 Aspartate/glutamate carrier - Glutamate and H+ for aspartate
R00205MM Methylglyoxal+NADP++H2O-->Pyruvate+NADPH+H+
R00214MM (S)-Malate+NAD+-->Pyruvate+CO2+NADH+H+
R03381MM (S)-Methylmalonatesemialdehyde+CoA+NAD+-->(R)-2-Methyl-3-oxopropanoyl-CoA+NADH+H+
Transporter35 deoxynucleotide carrier - dADP for ATP
R05066MM (S)-3-Hydroxyisobutyrate+NAD+-->(S)-Methylmalonatesemialdehyde+NADH+H+
R06985MM trans-Hex-2-enoyl-CoA+NADPH+H+-->Hexanoyl-CoA+NADP+
R04954MM (R)-3-Hydroxyhexanoyl-[acp]-->trans-Hex-2-enoyl-[acp]+H2O
R04956MM Hexanoyl-[acp]+NADP+-->trans-Hex-2-enoyl-[acp]+NADPH+H+
R04170MM (S)-3-Hydroxydodecanoyl-CoA-->2-trans-Dodecenoyl-CoA+H2O
R00716MM N6-(L-1,3-Dicarboxypropyl)-L-lysine+NADP++H2O-->L-Lysine+2-Oxoglutarate+NADPH+H+
R04095MM 3-Methylbutanoyl-CoA+FAD-->3-Methylcrotonyl-CoA+FADH2
R01280MM ATP+Hexadecanoicacid+CoA-->AMP+Palmitoyl-CoA+Pyrophosphate
Transporter44 carnitine carrier - Carnitine out, palmitoyl/acyl carnitine in
R07604MM 2-Methyl-1-hydroxybutyl-ThPP+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(2-methylbutanoyl)dihydrolipoyllysine+Thiamindiphosphate
R00572MM CTP+Pyruvate-->CDP+Phosphoenolpyruvate
R03220Cyto CoproporphyrinogenIII+Oxygen-->ProtoporphyrinogenIX+2CO2+2H2O
R01778MM (3S)-3-Hydroxyacyl-CoA+NAD+-->3-Oxoacyl-CoA+NADH+H+
R04225MM (S)-3-Methyl-2-oxopentanoicacid+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(2-methylbutanoyl)dihydrolipoyllysine+CO2
R00355Cyto L-Aspartate+2-Oxoglutarate-->Oxaloacetate+L-Glutamate
R00268MM Oxalosuccinate-->2-Oxoglutarate+CO2
R02313MM N6-(L-1,3-Dicarboxypropyl)-L-lysine+NAD++H2O-->L-Glutamate+L-2-Aminoadipate6-semialdehyde+NADH+H+
Transporter79 Unknown carrier - (R)-3-Hydroxybutanoate
R04743MM (S)-Hydroxydecanoyl-CoA+NAD+-->3-Oxodecanoyl-CoA+NADH+H+
R01177MM Acetyl-CoA+Butanoyl-CoA-->CoA+3-Oxohexanoyl-CoA
R03758MM Aminoacetone+CO2-->L-2-Amino-3-oxobutanoicacid
R01939MM L-2-Aminoadipate+2-Oxoglutarate-->2-Oxoadipate+L-Glutamate
R04537MM (3R)-3-Hydroxyoctanoyl-[acyl-carrierprotein]-->trans-Oct-2-enoyl-[acp]+H2O
R03026MM (S)-3-Hydroxybutanoyl-CoA-->Crotonoyl-CoA+H2O
R03102MM L-2-Aminoadipate6-semialdehyde+NAD++H2O-->L-2-Aminoadipate+NADH+H+
R02662MM 2-Methylpropanoyl-CoA+EnzymeN6-(dihydrolipoyl)lysine-->CoA+[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(2-methylpropanoyl)dihydrolipoyllysine
R00355MM L-Aspartate+2-Oxoglutarate-->Oxaloacetate+L-Glutamate
R00248MM L-Glutamate+NADP++H2O-->2-Oxoglutarate+NH3+NADPH+H+
Transporter45 carnitine carrier - Carnitine out
R08157MM Octanoyl-[acp]+H2O-->Acyl-carrierprotein+Octanoicacid
R04970MM Hexadecanoyl-[acp]+NADP+-->trans-Hexadec-2-enoyl-[acp]+NADPH+H+
R00842Cyto sn-Glycerol3-phosphate+NAD+-->Glyceronephosphate+NADH+H+
Transporter66 Unknown amino acid carrier - L-Glutamine
R00895MM L-Cysteine+2-Oxoglutarate-->Mercaptopyruvate+L-Glutamate
R00711MM Acetaldehyde+NADP++H2O-->Acetate+NADPH+H+
Transporter3 Citrate carrier - PEP for citrate
R01940MM 2-Oxoadipate+Lipoamide-->S-Glutaryldihydrolipoamide+CO2
R01975MM (S)-3-Hydroxybutanoyl-CoA+NAD+-->Acetoacetyl-CoA+NADH+H+
Transporter68 Unknown amino acid carrier - L-Tyrosine
R04543MM (3R)-3-Hydroxypalmitoyl-[acyl-carrierprotein]+NADP+-->3-Oxohexadecanoyl-[acp]+NADPH+H+
R04544MM (3R)-3-Hydroxypalmitoyl-[acyl-carrierprotein]-->trans-Hexadec-2-enoyl-[acp]+H2O
R02740Cyto alpha-D-Glucose6-phosphate-->beta-D-Fructose6-phosphate
R01702MM 4-Methyl-2-oxopentanoate+EnzymeN6-(lipoyl)lysine-->[Dihydrolipoyllysine-residue(2-methylpropanoyl)transferase]S-(3-methylbutanoyl)dihydrolipoyllysine+CO2
Transporter31 deoxynucleotide carrier - dATP for ATP
R01518Cyto 2-Phospho-D-glycerate-->3-Phospho-D-glycerate
Transporter32 deoxynucleotide carrier - dGTP for ATP
R00014MM Pyruvate+Thiamindiphosphate-->2-(alpha-Hydroxyethyl)thiaminediphosphate+CO2
R00371MM Acetyl-CoA+Glycine-->CoA+L-2-Amino-3-oxobutanoicacid
R00258MM L-Alanine+2-Oxoglutarate-->Pyruvate+L-Glutamate
R04952MM Butyryl-[acp]+Malonyl-[acyl-carrierprotein]-->3-Oxohexanoyl-[acp]+CO2+Acyl-carrierprotein
R04953MM (R)-3-Hydroxyhexanoyl-[acp]+NADP+-->3-Oxohexanoyl-[acp]+NADPH+H+
R02164MM COMPLEX_II_Ubiquinone+Succinate-->Ubiquinol+Fumarate