MODEL1106080000
type: SBMLModel
reaction: 304697
reaction: 303623
reaction: 303800
species: 302736
species: 303404
species: 303176
species: 302648
species: 303050
reaction: 304437
species: 302742
reaction: 304844
species: 302654
reaction: 303587
species: 302909
reaction: 303797
species: 303242
species: 302813
reaction: 304125
reaction: 304817
reaction: 304302
species: 302981
reaction: 303806
reaction: 304512
reaction: 303971
reaction: 304308
species: 302672
reaction: 304263
reaction: 304046
species: 302804
reaction: 303944
species: 303248
time units: MODEL1105180000#
species: 302972
species: 303152
species: 302639
reaction: 304715
reaction: 304200
reaction: 304473
reaction: 304650
species: 302526
reaction: 303632
species: 303347
reaction: 304446
species: 302583
reaction: 304161
reaction: 304656
reaction: 304853
reaction: 303878
reaction: 304880
reaction: 303842
species: 302657
reaction: 304134
reaction: 304629
is described by: http://identifiers.org/pubmed/21749716
species: 302517
species: 303413
reaction: 304584
reaction: 303638
reaction: 303593
reaction: 303815
reaction: 303770
species: 303365
reaction: 303980
species: 302756
reaction: 304859
species: 303041
reaction: 303566
reaction: 304272
reaction: 303776
species: 302762
species: 303431
reaction: 304787
species: 302822
species: 302594
reaction: 303749
reaction: 304482
reaction: 304025
species: 303095
reaction: 304278

304697
type: Reaction
product: 028449
reactant: 028437
kinetic law: 028473
product: 028461
reversible: false
notes: GENE_ASSOCIATION: Ppa2.1 or Ppa2.2 or Ppa2.3 or Ppa2.4 SUBSYSTEM: Oxidative Phosphorylation EC Number: Confidence Level: AUTHORS:
fast: false
name: inorganic diphosphatase
reactant: 028425

028449
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species: 302819

302819
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: H+

302469
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Cytoplasm

028437
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stoichiometry: 1.0
species: 303143

303143
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notes: CHARGE: 0
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Diphosphate

309551
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value: 0.0

006317
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scale: 0
multipler: 2.77777777777778E-4
kind: SECOND

006305
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scale: 0
multipler: 1.0
kind: GRAM

006293
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scale: -3
multipler: 1.0
kind: MOLE

309549
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value: 0.0

309547
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value: 1000.0

309545
type: LocalParameter
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value: 0.0

028461
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species: 303131

303131
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Phosphate

028425
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species: 302822

302822
type: Species
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: H2O

303623
type: Reaction
kinetic law: 007481
reactant: 007469
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Leukotriene B4 exchange

305453
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units: 006281
value: 0.0

305450
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value: 0.0

305447
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value: 2.4E-6

305444
type: LocalParameter
units: 006281
value: 0.0

007469
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species: 303398

303398
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Leukotriene B4

302472
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Extracellular

303800
type: Reaction
name: N-Acetylneuraminate 9-phosphate pyruvate-lyase (pyruvate-phosphorylating)
reactant: 009200
reactant: 009187
reactant: 009212
notes: GENE_ASSOCIATION: Nans.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 009249
reversible: false
product: 009237
product: 009224
fast: false

009200
type: SpeciesReference
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species: 302822

009187
type: SpeciesReference
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species: 302535

302535
type: Species
notes: CHARGE: 0
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetyl-D-mannosamine 6-phosphate

009212
type: SpeciesReference
stoichiometry: 1.0
species: 303119

303119
type: Species
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Phosphoenolpyruvate

306161
type: LocalParameter
units: 006281
value: 0.0

306158
type: LocalParameter
units: 006281
value: 0.0

306155
type: LocalParameter
units: 006281
value: 1000.0

306152
type: LocalParameter
units: 006281
value: 0.0

009237
type: SpeciesReference
stoichiometry: 1.0
species: 303131

009224
type: SpeciesReference
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species: 302541

302541
type: Species
notes: CHARGE: 0
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetylneuraminate 9-phosphate

302736
type: Species
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: FMN

303404
type: Species
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Malate

303176
type: Species
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constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: alpha-D-Ribose 1-phosphate

302648
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Chloride

303050
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:2, C18:1)

304437
type: Reaction
kinetic law: 022741
product: 022729
reactant: 022717
notes: GENE_ASSOCIATION: Slc22a2.2 or Slc22a2.1 or Slc22a3.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Norepinephrine uniport

308715
type: LocalParameter
units: 006281
value: 0.0

308712
type: LocalParameter
units: 006281
value: 0.0

308709
type: LocalParameter
units: 006281
value: 1000.0

308706
type: LocalParameter
units: 006281
value: -1000.0

022729
type: SpeciesReference
stoichiometry: 1.0
species: 302963

302963
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Norepinephrine

022717
type: SpeciesReference
stoichiometry: 1.0
species: 303431

303431
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Norepinephrine

302742
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Fructose

304844
type: Reaction
product: 031469
reversible: false
fast: false
name: thiamine-diphosphate kinase
kinetic law: 031493
reactant: 031445
product: 031481
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 031457

031469
type: SpeciesReference
stoichiometry: 1.0
species: 302549

302549
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: ADP

309943
type: LocalParameter
units: 006281
value: 0.0

309941
type: LocalParameter
units: 006281
value: 0.0

309939
type: LocalParameter
units: 006281
value: 1000.0

309937
type: LocalParameter
units: 006281
value: 0.0

031445
type: SpeciesReference
stoichiometry: 1.0
species: 302589

302589
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: ATP

031481
type: SpeciesReference
stoichiometry: 1.0
species: 303212

303212
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Thiamin triphosphate

031457
type: SpeciesReference
stoichiometry: 1.0
species: 303209

303209
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Thiamine diphosphate

302654
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Carbon monoxide

303587
type: Reaction
kinetic law: 007191
reactant: 007179
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: H+ exchange

305309
type: LocalParameter
units: 006281
value: 0.0

305306
type: LocalParameter
units: 006281
value: 0.0

305303
type: LocalParameter
units: 006281
value: 10.0

305300
type: LocalParameter
units: 006281
value: -0.900450000000104

007179
type: SpeciesReference
stoichiometry: 1.0
species: 303362

303362
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: H+

302909
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1,3,4,5-tetrakisphosphate

303797
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: Nagk.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
name: N-acetylglucosamine kinase
product: 009151
reactant: 009115
kinetic law: 009175
reactant: 009127
product: 009139
product: 009163

009151
type: SpeciesReference
stoichiometry: 1.0
species: 302549

009115
type: SpeciesReference
stoichiometry: 1.0
species: 302526

302526
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetyl-D-glucosamine

306149
type: LocalParameter
units: 006281
value: 0.0

306146
type: LocalParameter
units: 006281
value: 0.0

306143
type: LocalParameter
units: 006281
value: 1000.0

306140
type: LocalParameter
units: 006281
value: 0.0

009127
type: SpeciesReference
stoichiometry: 1.0
species: 302589

009139
type: SpeciesReference
stoichiometry: 1.0
species: 302529

302529
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetyl-D-glucosamine 6-phosphate

009163
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303242
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Xanthosine 5'-phosphate

302813
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Guanine

304125
type: Reaction
name: Ferrochelatase
reactant: 016250
product: 016262
kinetic law: 016286
product: 016274
fast: false
reversible: false
reactant: 016238
notes: GENE_ASSOCIATION: Fech.1 or Fech.2 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:

016250
type: SpeciesReference
stoichiometry: 1.0
species: 303146

303146
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Protoporphyrin

016262
type: SpeciesReference
stoichiometry: 2.0
species: 302819

307467
type: LocalParameter
units: 006281
value: 0.0

307464
type: LocalParameter
units: 006281
value: 0.0

307461
type: LocalParameter
units: 006281
value: 1000.0

307458
type: LocalParameter
units: 006281
value: 0.0

016274
type: SpeciesReference
stoichiometry: 1.0
species: 303125

303125
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Protoheme

016238
type: SpeciesReference
stoichiometry: 1.0
species: 302733

302733
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Fe2+

304817
type: Reaction
reactant: 030924
product: 030936
reversible: true
product: 030948
fast: false
kinetic law: 030960
name: spermine transport via proton antiport
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 030912

030924
type: SpeciesReference
stoichiometry: 1.0
species: 303470

303470
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Spermine

030936
type: SpeciesReference
stoichiometry: 1.0
species: 303200

303200
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Spermine

030948
type: SpeciesReference
stoichiometry: 1.0
species: 303362

309871
type: LocalParameter
units: 006281
value: 0.0

309869
type: LocalParameter
units: 006281
value: 0.0

309867
type: LocalParameter
units: 006281
value: 1000.0

309865
type: LocalParameter
units: 006281
value: -1000.0

030912
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304302
type: Reaction
name: K+-Cl- cotransport
reactant: 020038
product: 020050
fast: false
reactant: 020026
reversible: true
notes: GENE_ASSOCIATION: Slc12a7.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 020074
product: 020062

020038
type: SpeciesReference
stoichiometry: 1.0
species: 303386

303386
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: potassium

020050
type: SpeciesReference
stoichiometry: 1.0
species: 302648

020026
type: SpeciesReference
stoichiometry: 1.0
species: 303308

303308
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Chloride

308175
type: LocalParameter
units: 006281
value: 0.0

308172
type: LocalParameter
units: 006281
value: 0.0

308169
type: LocalParameter
units: 006281
value: 1000.0

308166
type: LocalParameter
units: 006281
value: -1000.0

020062
type: SpeciesReference
stoichiometry: 1.0
species: 302855

302855
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: potassium

302981
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Ornithine

303806
type: Reaction
fast: false
reactant: 009321
reactant: 009333
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
name: N-acetylneuraminate proton symport
kinetic law: 009369
product: 009345
product: 009357
reversible: false

009321
type: SpeciesReference
stoichiometry: 1.0
species: 303275

303275
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: N-Acetylneuraminate

009333
type: SpeciesReference
stoichiometry: 1.0
species: 303362

306185
type: LocalParameter
units: 006281
value: 0.0

306182
type: LocalParameter
units: 006281
value: 0.0

306179
type: LocalParameter
units: 006281
value: 1000.0

306176
type: LocalParameter
units: 006281
value: 0.0

009345
type: SpeciesReference
stoichiometry: 1.0
species: 302538

302538
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetylneuraminate

009357
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304512
type: Reaction
kinetic law: 024273
product: 024261
reactant: 024249
notes: GENE_ASSOCIATION: Pgm2 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: phosphoglucomutase

309015
type: LocalParameter
units: 006281
value: 0.0

309012
type: LocalParameter
units: 006281
value: 0.0

309009
type: LocalParameter
units: 006281
value: 1000.0

309006
type: LocalParameter
units: 006281
value: -1000.0

024261
type: SpeciesReference
stoichiometry: 1.0
species: 302756

302756
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucose 6-phosphate

024249
type: SpeciesReference
stoichiometry: 1.0
species: 302748

302748
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucose 1-phosphate

303971
type: Reaction
kinetic law: 012861
reactant: 012813
reactant: 012825
product: 012849
product: 012837
fast: false
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 012801
name: phosphatidate cytidylyltransferase (C18:1,C18:2)
reversible: false

306845
type: LocalParameter
units: 006281
value: 0.0

306842
type: LocalParameter
units: 006281
value: 0.0

306839
type: LocalParameter
units: 006281
value: 1000.0

306836
type: LocalParameter
units: 006281
value: 0.0

012813
type: SpeciesReference
stoichiometry: 1.0
species: 302819

012825
type: SpeciesReference
stoichiometry: 1.0
species: 303002

303002
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C18:1, C18:2)

012849
type: SpeciesReference
stoichiometry: 1.0
species: 303143

012837
type: SpeciesReference
stoichiometry: 1.0
species: 302630

302630
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C18:1, C18:2)

012801
type: SpeciesReference
stoichiometry: 1.0
species: 302669

302669
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CTP

304308
type: Reaction
product: 020194
kinetic law: 020206
product: 020182
product: 020170
fast: false
reversible: true
reactant: 020158
name: L-lactate dehydrogenase
reactant: 020146
notes: GENE_ASSOCIATION: Ldhb.1 or Ldha.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:

020194
type: SpeciesReference
stoichiometry: 1.0
species: 303173

303173
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyruvate

308199
type: LocalParameter
units: 006281
value: 0.0

308196
type: LocalParameter
units: 006281
value: 0.0

308193
type: LocalParameter
units: 006281
value: 1000.0

308190
type: LocalParameter
units: 006281
value: -1000.0

020182
type: SpeciesReference
stoichiometry: 1.0
species: 302936

302936
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide adenine dinucleotide - reduced

020170
type: SpeciesReference
stoichiometry: 1.0
species: 302819

020158
type: SpeciesReference
stoichiometry: 1.0
species: 302933

302933
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide adenine dinucleotide

020146
type: SpeciesReference
stoichiometry: 1.0
species: 302861

302861
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Lactate

302672
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Cysteine

304263
type: Reaction
kinetic law: 019214
product: 019202
reactant: 019189
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: fatty acid transport via diffusion

308019
type: LocalParameter
units: 006281
value: 0.0

308016
type: LocalParameter
units: 006281
value: 0.0

308013
type: LocalParameter
units: 006281
value: 1000.0

308010
type: LocalParameter
units: 006281
value: -1000.0

019202
type: SpeciesReference
stoichiometry: 1.0
species: 302834

302834
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Hexadecanoate (n-C16:0)

019189
type: SpeciesReference
stoichiometry: 1.0
species: 303377

303377
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Hexadecanoate (n-C16:0)

304046
type: Reaction
kinetic law: 014581
product: 014569
reactant: 014557
notes: GENE_ASSOCIATION: Slc43a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-cysteine transport via diffusion (extracellular to cytosol)

307143
type: LocalParameter
units: 006281
value: 0.0

307140
type: LocalParameter
units: 006281
value: 0.0

307137
type: LocalParameter
units: 006281
value: 1000.0

307134
type: LocalParameter
units: 006281
value: -1000.0

014569
type: SpeciesReference
stoichiometry: 1.0
species: 302672

014557
type: SpeciesReference
stoichiometry: 1.0
species: 303317

303317
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Cysteine

302804
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Oxidized glutathione

303944
type: Reaction
product: 012172
reactant: 012148
reactant: 012160
product: 012185
reversible: true
kinetic law: 012209
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 012197
fast: false
name: phosphatidylinositol synthase (Homo sapiens, C16:0, C18:2)

012172
type: SpeciesReference
stoichiometry: 1.0
species: 302651

302651
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CMP

012148
type: SpeciesReference
stoichiometry: 1.0
species: 302624

302624
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C16:0, C18:2)

012160
type: SpeciesReference
stoichiometry: 1.0
species: 302849

302849
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: myo-Inositol

012185
type: SpeciesReference
stoichiometry: 1.0
species: 302819

306737
type: LocalParameter
units: 006281
value: 0.0

306734
type: LocalParameter
units: 006281
value: 0.0

306731
type: LocalParameter
units: 006281
value: 1000.0

306728
type: LocalParameter
units: 006281
value: -1000.0

012197
type: SpeciesReference
stoichiometry: 1.0
species: 303059

303059
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C16:0, C18:2)

303248
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Xylitol

302972
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: octadecenoate (n-C18:1)

303152
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Phospho-alpha-D-ribose 1-diphosphate

302639
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDPethanolamine

304715
type: Reaction
reactant: 028786
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
fast: false
product: 028810
product: 028822
name: phosphatidic acid phosphatase (C18:2, C16:0)
kinetic law: 028834
reversible: false
reactant: 028798

028786
type: SpeciesReference
stoichiometry: 1.0
species: 302822

028810
type: SpeciesReference
stoichiometry: 1.0
species: 302690

302690
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C18:2, C16:0)

028822
type: SpeciesReference
stoichiometry: 1.0
species: 303131

309599
type: LocalParameter
units: 006281
value: 0.0

309597
type: LocalParameter
units: 006281
value: 0.0

309595
type: LocalParameter
units: 006281
value: 1000.0

309593
type: LocalParameter
units: 006281
value: 0.0

028798
type: SpeciesReference
stoichiometry: 1.0
species: 303005

303005
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C18:2, C16:0)

304200
type: Reaction
reactant: 017778
kinetic law: 017850
product: 017814
product: 017826
product: 017838
reactant: 017790
fast: false
notes: GENE_ASSOCIATION: GmpR.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
name: GMP reductase
reactant: 017802
reversible: false

017778
type: SpeciesReference
stoichiometry: 1.0
species: 302798

302798
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: GMP

307767
type: LocalParameter
units: 006281
value: 0.0

307764
type: LocalParameter
units: 006281
value: 0.0

307761
type: LocalParameter
units: 006281
value: 1000.0

307758
type: LocalParameter
units: 006281
value: 0.0

017814
type: SpeciesReference
stoichiometry: 1.0
species: 302846

302846
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: IMP

017826
type: SpeciesReference
stoichiometry: 1.0
species: 302939

302939
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide adenine dinucleotide phosphate

017838
type: SpeciesReference
stoichiometry: 1.0
species: 302948

302948
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Ammonium

017790
type: SpeciesReference
stoichiometry: 2.0
species: 302819

017802
type: SpeciesReference
stoichiometry: 1.0
species: 302942

302942
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide adenine dinucleotide phosphate - reduced

304473
type: Reaction
reactant: 023475
kinetic law: 023523
fast: false
name: Ornithine Decarboxylase
notes: GENE_ASSOCIATION: Odc1.1 SUBSYSTEM: Urea cycle/amino group metabolism EC Number: Confidence Level: AUTHORS:
product: 023511
reversible: false
product: 023499
reactant: 023487

023475
type: SpeciesReference
stoichiometry: 1.0
species: 302819

308859
type: LocalParameter
units: 006281
value: 0.0

308856
type: LocalParameter
units: 006281
value: 0.0

308853
type: LocalParameter
units: 006281
value: 1000.0

308850
type: LocalParameter
units: 006281
value: 0.0

023511
type: SpeciesReference
stoichiometry: 1.0
species: 303155

303155
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Putrescine

023499
type: SpeciesReference
stoichiometry: 1.0
species: 302657

302657
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CO2

023487
type: SpeciesReference
stoichiometry: 1.0
species: 302981

304650
type: Reaction
reactant: 027332
product: 027380
reactant: 027344
product: 027356
product: 027368
reversible: false
kinetic law: 027392
name: phosphatidylinositol phospholipase C (C16:0,C18:1)
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false

027332
type: SpeciesReference
stoichiometry: 1.0
species: 302822

027380
type: SpeciesReference
stoichiometry: 1.0
species: 302921

302921
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1-phosphate

027344
type: SpeciesReference
stoichiometry: 1.0
species: 303056

303056
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C16:0, C18:1)

027356
type: SpeciesReference
stoichiometry: 1.0
species: 302678

302678
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C16:0, C18:1)

027368
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309423
type: LocalParameter
units: 006281
value: 0.0

309421
type: LocalParameter
units: 006281
value: 0.0

309419
type: LocalParameter
units: 006281
value: 1000.0

309417
type: LocalParameter
units: 006281
value: 0.0

303632
type: Reaction
kinetic law: 007553
reactant: 007541
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-Mannose exchange

305489
type: LocalParameter
units: 006281
value: 0.0

305486
type: LocalParameter
units: 006281
value: 0.0

305483
type: LocalParameter
units: 006281
value: 0.0

305480
type: LocalParameter
units: 006281
value: -0.01

007541
type: SpeciesReference
stoichiometry: 1.0
species: 303407

303407
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Mannose

303347
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Glutamine

304446
type: Reaction
name: 5'-nucleotidase (UMP)
kinetic law: 022929
fast: false
reactant: 022877
reversible: false
product: 022916
reactant: 022890
notes: GENE_ASSOCIATION: Nt5C3.1 SUBSYSTEM: Pyrimidine Catabolism EC Number: Confidence Level: AUTHORS:
product: 022903

308751
type: LocalParameter
units: 006281
value: 0.0

308748
type: LocalParameter
units: 006281
value: 0.0

308745
type: LocalParameter
units: 006281
value: 1000.0

308742
type: LocalParameter
units: 006281
value: 0.0

022877
type: SpeciesReference
stoichiometry: 1.0
species: 302822

022916
type: SpeciesReference
stoichiometry: 1.0
species: 303236

303236
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Uridine

022890
type: SpeciesReference
stoichiometry: 1.0
species: 303227

303227
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UMP

022903
type: SpeciesReference
stoichiometry: 1.0
species: 303131

302583
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Arginine

304161
type: Reaction
kinetic law: 016978
product: 016966
reactant: 016953
notes: GENE_ASSOCIATION: Slc2a1.1-e or Slc2a3.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: galactose transport (uniport)

307611
type: LocalParameter
units: 006281
value: 0.0

307608
type: LocalParameter
units: 006281
value: 0.0

307605
type: LocalParameter
units: 006281
value: 1000.0

307602
type: LocalParameter
units: 006281
value: -1000.0

016966
type: SpeciesReference
stoichiometry: 1.0
species: 302759

302759
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Galactose

016953
type: SpeciesReference
stoichiometry: 1.0
species: 303338

303338
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Galactose

304656
type: Reaction
fast: false
name: phosphatidylinositol phospholipase C (C18:1,C18:1)
reactant: 027476
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 027536
product: 027524
product: 027500
reactant: 027488
product: 027512
reversible: false

027476
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309439
type: LocalParameter
units: 006281
value: 0.0

309437
type: LocalParameter
units: 006281
value: 0.0

309435
type: LocalParameter
units: 006281
value: 1000.0

309433
type: LocalParameter
units: 006281
value: 0.0

027524
type: SpeciesReference
stoichiometry: 1.0
species: 302921

027500
type: SpeciesReference
stoichiometry: 1.0
species: 302684

302684
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C18:1, C18:1)

027488
type: SpeciesReference
stoichiometry: 1.0
species: 303062

303062
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C18:1, C18:1)

027512
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304853
type: Reaction
reactant: 031601
reactant: 031577
product: 031625
name: UDPglucose 6-dehydrogenase
product: 031637
product: 031613
reversible: false
reactant: 031589
kinetic law: 031649
fast: false
notes: GENE_ASSOCIATION: Ugdh.1 SUBSYSTEM: Starch and Sucrose Metabolism EC Number: Confidence Level: AUTHORS:

031601
type: SpeciesReference
stoichiometry: 1.0
species: 303218

303218
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UDPglucose

031577
type: SpeciesReference
stoichiometry: 1.0
species: 302822

031625
type: SpeciesReference
stoichiometry: 2.0
species: 302936

031637
type: SpeciesReference
stoichiometry: 1.0
species: 303224

303224
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UDP-D-glucuronate

031613
type: SpeciesReference
stoichiometry: 3.0
species: 302819

031589
type: SpeciesReference
stoichiometry: 2.0
species: 302933

309967
type: LocalParameter
units: 006281
value: 0.0

309965
type: LocalParameter
units: 006281
value: 0.0

309963
type: LocalParameter
units: 006281
value: 1000.0

309961
type: LocalParameter
units: 006281
value: 0.0

303878
type: Reaction
name: N-acetyl-D-mannosamine kinase
reactant: 010730
reactant: 010718
product: 010766
notes: GENE_ASSOCIATION: Nagk.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
product: 010754
kinetic law: 010778
product: 010742
reversible: false
fast: false

010730
type: SpeciesReference
stoichiometry: 1.0
species: 302589

010718
type: SpeciesReference
stoichiometry: 1.0
species: 302532

302532
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Acetyl-D-mannosamine

010766
type: SpeciesReference
stoichiometry: 1.0
species: 302819

010754
type: SpeciesReference
stoichiometry: 1.0
species: 302549

306473
type: LocalParameter
units: 006281
value: 0.0

306470
type: LocalParameter
units: 006281
value: 0.0

306467
type: LocalParameter
units: 006281
value: 1000.0

306464
type: LocalParameter
units: 006281
value: 0.0

010742
type: SpeciesReference
stoichiometry: 1.0
species: 302535

304880
type: Reaction
reversible: true
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
name: xylitol dehydrogenase (D-xyulose-forming)
kinetic law: 032167
product: 032143
reactant: 032119
reactant: 032107
product: 032155
product: 032131

310039
type: LocalParameter
units: 006281
value: 0.0

310037
type: LocalParameter
units: 006281
value: 0.0

310035
type: LocalParameter
units: 006281
value: 1000.0

310033
type: LocalParameter
units: 006281
value: -1000.0

032143
type: SpeciesReference
stoichiometry: 1.0
species: 302936

032119
type: SpeciesReference
stoichiometry: 1.0
species: 303248

032107
type: SpeciesReference
stoichiometry: 1.0
species: 302933

032155
type: SpeciesReference
stoichiometry: 1.0
species: 303251

303251
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Xylulose

032131
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303842
type: Reaction
kinetic law: 010017
product: 010004
reactant: 009992
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Adrenaline (epinephrine) transport, uniport

306329
type: LocalParameter
units: 006281
value: 0.0

306326
type: LocalParameter
units: 006281
value: 0.0

306323
type: LocalParameter
units: 006281
value: 1000.0

306320
type: LocalParameter
units: 006281
value: -1000.0

010004
type: SpeciesReference
stoichiometry: 1.0
species: 302554

302554
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Adrenaline

009992
type: SpeciesReference
stoichiometry: 1.0
species: 303284

303284
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Adrenaline

304134
type: Reaction
kinetic law: 016431
product: 016419
reactant: 016407
notes: GENE_ASSOCIATION: Slc2a8.1-e or Slc2a7.1-e or Slc2a11.1-e or Slc2a2.1-e or Slc2a5.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: D-fructose transport in via uniport

307503
type: LocalParameter
units: 006281
value: 0.0

307500
type: LocalParameter
units: 006281
value: 0.0

307497
type: LocalParameter
units: 006281
value: 1000.0

307494
type: LocalParameter
units: 006281
value: -1000.0

016419
type: SpeciesReference
stoichiometry: 1.0
species: 302742

016407
type: SpeciesReference
stoichiometry: 1.0
species: 303332

303332
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Fructose

304629
type: Reaction
kinetic law: 026885
product: 026873
reactant: 026837
product: 026861
product: 026849
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false
name: phosphatidylinositol 4-kinase (C16:0,C18:1)
reactant: 026825

309367
type: LocalParameter
units: 006281
value: 0.0

309365
type: LocalParameter
units: 006281
value: 0.0

309363
type: LocalParameter
units: 006281
value: 1000.0

309361
type: LocalParameter
units: 006281
value: 0.0

026873
type: SpeciesReference
stoichiometry: 1.0
species: 303035

303035
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C18:1)

026837
type: SpeciesReference
stoichiometry: 1.0
species: 303056

026861
type: SpeciesReference
stoichiometry: 1.0
species: 302819

026849
type: SpeciesReference
stoichiometry: 1.0
species: 302549

026825
type: SpeciesReference
stoichiometry: 1.0
species: 302589

302517
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 6-phospho-D-glucono-1,5-lactone

303413
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Methionine

304584
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-phosphate phospholipase C (C16:0,C16:0)
fast: false
product: 025843
product: 025868
reactant: 025818
product: 025856
kinetic law: 025880
reactant: 025830

025843
type: SpeciesReference
stoichiometry: 1.0
species: 302675

302675
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C16:0, C16:0)

025868
type: SpeciesReference
stoichiometry: 1.0
species: 302918

302918
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1,4-bisphosphate

025818
type: SpeciesReference
stoichiometry: 1.0
species: 302822

025856
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309247
type: LocalParameter
units: 006281
value: 0.0

309245
type: LocalParameter
units: 006281
value: 0.0

309243
type: LocalParameter
units: 006281
value: 1000.0

309241
type: LocalParameter
units: 006281
value: 0.0

025830
type: SpeciesReference
stoichiometry: 1.0
species: 303032

303032
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C16:0)

303638
type: Reaction
kinetic law: 007601
reactant: 007589
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Methionine exchange

305513
type: LocalParameter
units: 006281
value: 0.0

305510
type: LocalParameter
units: 006281
value: 0.0

305507
type: LocalParameter
units: 006281
value: 0.0

305504
type: LocalParameter
units: 006281
value: -0.01

007589
type: SpeciesReference
stoichiometry: 1.0
species: 303413

303593
type: Reaction
kinetic law: 007239
reactant: 007227
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Hydrogen peroxide exchange

305333
type: LocalParameter
units: 006281
value: 0.0

305330
type: LocalParameter
units: 006281
value: 0.0

305327
type: LocalParameter
units: 006281
value: 6.11000000006356E-4

305324
type: LocalParameter
units: 006281
value: -10.0

007227
type: SpeciesReference
stoichiometry: 1.0
species: 303368

303368
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Hydrogen peroxide

303815
type: Reaction
product: 009526
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 009502
kinetic law: 009538
name: acetate reversible transport via proton symport
reactant: 009490
fast: false
product: 009514

009526
type: SpeciesReference
stoichiometry: 1.0
species: 302819

009502
type: SpeciesReference
stoichiometry: 1.0
species: 303362

306221
type: LocalParameter
units: 006281
value: 0.0

306218
type: LocalParameter
units: 006281
value: 0.0

306215
type: LocalParameter
units: 006281
value: 1000.0

306212
type: LocalParameter
units: 006281
value: -1000.0

009490
type: SpeciesReference
stoichiometry: 1.0
species: 303269

303269
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Acetate

009514
type: SpeciesReference
stoichiometry: 1.0
species: 302520

302520
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Acetate

303770
type: Reaction
kinetic law: 008668
reactant: 008655
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: sink pe hs 18 1 18 2(c)

306041
type: LocalParameter
units: 006281
value: 0.0

306038
type: LocalParameter
units: 006281
value: 0.0

306035
type: LocalParameter
units: 006281
value: 1000.0

306032
type: LocalParameter
units: 006281
value: 0.0

008655
type: SpeciesReference
stoichiometry: 1.0
species: 303110

303110
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C18:1, C18:2)

303365
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: H2O

303980
type: Reaction
fast: false
product: 013055
product: 013043
name: choline phosphotransferase (C16:0, C16:0)
reactant: 013031
kinetic law: 013079
reversible: false
reactant: 013019
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013067

013055
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013043
type: SpeciesReference
stoichiometry: 1.0
species: 302651

013031
type: SpeciesReference
stoichiometry: 1.0
species: 302675

306881
type: LocalParameter
units: 006281
value: 0.0

306878
type: LocalParameter
units: 006281
value: 0.0

306875
type: LocalParameter
units: 006281
value: 1000.0

306872
type: LocalParameter
units: 006281
value: 0.0

013019
type: SpeciesReference
stoichiometry: 1.0
species: 302615

302615
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDPcholine

013067
type: SpeciesReference
stoichiometry: 1.0
species: 303074

303074
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C16:0, C16:0)

304859
type: Reaction
product: 031758
reversible: true
notes: GENE_ASSOCIATION: Galt.1 or Galt.2 or Galt.3 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 031782
reactant: 031746
fast: false
name: UDPglucose--hexose-1-phosphate uridylyltransferase
reactant: 031733
product: 031770

031758
type: SpeciesReference
stoichiometry: 1.0
species: 302748

309983
type: LocalParameter
units: 006281
value: 0.0

309981
type: LocalParameter
units: 006281
value: 0.0

309979
type: LocalParameter
units: 006281
value: 1000.0

309977
type: LocalParameter
units: 006281
value: -1000.0

031746
type: SpeciesReference
stoichiometry: 1.0
species: 303218

031733
type: SpeciesReference
stoichiometry: 1.0
species: 302762

302762
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: alpha-D-Galactose 1-phosphate

031770
type: SpeciesReference
stoichiometry: 1.0
species: 303221

303221
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UDPgalactose

303041
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:1, C18:1)

303566
type: Reaction
kinetic law: 007019
reactant: 007007
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-Glucosamine exchange

305225
type: LocalParameter
units: 006281
value: 0.0

305222
type: LocalParameter
units: 006281
value: 0.0

305219
type: LocalParameter
units: 006281
value: 0.0

305216
type: LocalParameter
units: 006281
value: -1.0E-5

007007
type: SpeciesReference
stoichiometry: 1.0
species: 303341

303341
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Glucosamine

304272
type: Reaction
product: 019407
reversible: false
product: 019395
notes: GENE_ASSOCIATION: Hk1.1 or Hk1.3 or Hk1.4 or Hk1.2 or Hk1.5 or Hk3.1 or Flj22761.1 or Hk2.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
name: hexokinase (D-mannose:ATP)
fast: false
product: 019419
reactant: 019383
reactant: 019370
kinetic law: 019432

019407
type: SpeciesReference
stoichiometry: 1.0
species: 302819

019395
type: SpeciesReference
stoichiometry: 1.0
species: 302549

019419
type: SpeciesReference
stoichiometry: 1.0
species: 302900

302900
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Mannose 6-phosphate

019383
type: SpeciesReference
stoichiometry: 1.0
species: 302894

302894
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Mannose

019370
type: SpeciesReference
stoichiometry: 1.0
species: 302589

308055
type: LocalParameter
units: 006281
value: 0.0

308052
type: LocalParameter
units: 006281
value: 0.0

308049
type: LocalParameter
units: 006281
value: 1000.0

308046
type: LocalParameter
units: 006281
value: 0.0

303776
type: Reaction
kinetic law: 008716
reactant: 008704
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: sink pe hs 18 2 18 1(c)

306065
type: LocalParameter
units: 006281
value: 0.0

306062
type: LocalParameter
units: 006281
value: 0.0

306059
type: LocalParameter
units: 006281
value: 1000.0

306056
type: LocalParameter
units: 006281
value: 0.0

008704
type: SpeciesReference
stoichiometry: 1.0
species: 303116

303116
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C18:2, C18:1)

304787
type: Reaction
reactant: 030309
reactant: 030297
name: ribosylnicotinamide kinase
product: 030321
fast: false
product: 030333
notes: GENE_ASSOCIATION: Nrk1.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 030357
product: 030345
reversible: false

030309
type: SpeciesReference
stoichiometry: 1.0
species: 303185

303185
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: N-Ribosylnicotinamide

030297
type: SpeciesReference
stoichiometry: 1.0
species: 302589

030321
type: SpeciesReference
stoichiometry: 1.0
species: 302549

030333
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309791
type: LocalParameter
units: 006281
value: 0.0

309789
type: LocalParameter
units: 006281
value: 0.0

309787
type: LocalParameter
units: 006281
value: 1000.0

309785
type: LocalParameter
units: 006281
value: 0.0

030345
type: SpeciesReference
stoichiometry: 1.0
species: 302957

302957
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: NMN

302594
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Band membrane protein (methylated, universal, erythrocyte -> 2.1,3,4.1)

303749
type: Reaction
kinetic law: 008497
reactant: 008485
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 18 1 18 2(c)

305957
type: LocalParameter
units: 006281
value: 0.0

305954
type: LocalParameter
units: 006281
value: 0.0

305951
type: LocalParameter
units: 006281
value: 10.0

305948
type: LocalParameter
units: 006281
value: -10.0

008485
type: SpeciesReference
stoichiometry: 1.0
species: 303086

303086
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C18:1, C18:2)

304482
type: Reaction
kinetic law: 023705
reversible: false
product: 023681
name: 3',5'-cyclic-nucleotide phosphodiesterase
notes: GENE_ASSOCIATION: Pde8a.5 or Pde8a.3 or Pde8a.2 or Pde7A.2 or Pde11A.1 or Pde8a.1 or Pde1C.1 or Pde4C.1 or Pde4B.1 or Pde2A.1 or Pde3A.1 or Pde3B.2 or Pde7A.1 or Pde8b.1 or Pde7B.1 or Pde4A.1 or Pde1A.2 or Pde10A or Pde1B.1 or Pde4D.1 or Pde1A.1 or Pde8a.4 or Pde3B.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 023657
reactant: 023669
fast: false
product: 023693

308895
type: LocalParameter
units: 006281
value: 0.0

308892
type: LocalParameter
units: 006281
value: 0.0

308889
type: LocalParameter
units: 006281
value: 1000.0

308886
type: LocalParameter
units: 006281
value: 0.0

023681
type: SpeciesReference
stoichiometry: 1.0
species: 302578

302578
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: AMP

023657
type: SpeciesReference
stoichiometry: 1.0
species: 302609

302609
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: cAMP

023669
type: SpeciesReference
stoichiometry: 1.0
species: 302822

023693
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304025
type: Reaction
name: choline phosphate phosphatase
fast: false
kinetic law: 014182
product: 014170
notes: GENE_ASSOCIATION: Phospho1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 014146
reactant: 014134
reversible: false
product: 014158

307059
type: LocalParameter
units: 006281
value: 0.0

307056
type: LocalParameter
units: 006281
value: 0.0

307053
type: LocalParameter
units: 006281
value: 1000.0

307050
type: LocalParameter
units: 006281
value: 0.0

014170
type: SpeciesReference
stoichiometry: 1.0
species: 303131

014146
type: SpeciesReference
stoichiometry: 1.0
species: 302822

014134
type: SpeciesReference
stoichiometry: 1.0
species: 302645

302645
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Choline phosphate

014158
type: SpeciesReference
stoichiometry: 1.0
species: 302642

302642
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Choline

303095
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxine 5'-phosphate

304278
type: Reaction
notes: GENE_ASSOCIATION: Hmbs.1 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
name: hydroxymethylbilane synthase
fast: false
reactant: 019528
reversible: false
kinetic law: 019564
reactant: 019516
product: 019552
product: 019540

019528
type: SpeciesReference
stoichiometry: 4.0
species: 303140

303140
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Porphobilinogen

308079
type: LocalParameter
units: 006281
value: 0.0

308076
type: LocalParameter
units: 006281
value: 0.0

308073
type: LocalParameter
units: 006281
value: 1000.0

308070
type: LocalParameter
units: 006281
value: 0.0

019516
type: SpeciesReference
stoichiometry: 1.0
species: 302822

019552
type: SpeciesReference
stoichiometry: 4.0
species: 302948

019540
type: SpeciesReference
stoichiometry: 1.0
species: 302837

302837
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Hydroxymethylbilane

303923
type: Reaction
notes: GENE_ASSOCIATION: Cpt2.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
product: 011689
kinetic law: 011713
fast: false
product: 011701
reversible: false
name: carnitine octadecenoyl transferase
reactant: 011677
reactant: 011665

011689
type: SpeciesReference
stoichiometry: 1.0
species: 302666

302666
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Carnitine

306653
type: LocalParameter
units: 006281
value: 0.0

306650
type: LocalParameter
units: 006281
value: 0.0

306647
type: LocalParameter
units: 006281
value: 1000.0

306644
type: LocalParameter
units: 006281
value: 0.0

011701
type: SpeciesReference
stoichiometry: 1.0
species: 302975

302975
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Octadecenoyl-CoA (n-C18:1CoA)

011677
type: SpeciesReference
stoichiometry: 1.0
species: 302978

302978
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: octadecenoyl carnitine

011665
type: SpeciesReference
stoichiometry: 1.0
species: 302660

302660
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Coenzyme A

303422
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Nicotinamide

302828
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Bicarbonate

303254
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Xylulose

304685
type: Reaction
name: phospholipase A2 (C18:2,C16:0)
reactant: 028169
fast: false
product: 028193
product: 028218
product: 028205
reactant: 028181
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 028230
reversible: false

028169
type: SpeciesReference
stoichiometry: 1.0
species: 302822

028193
type: SpeciesReference
stoichiometry: 1.0
species: 302819

028218
type: SpeciesReference
stoichiometry: 1.0
species: 302888

302888
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidylcholine (homo sapiens, C18:2)

028205
type: SpeciesReference
stoichiometry: 1.0
species: 302834

028181
type: SpeciesReference
stoichiometry: 1.0
species: 303089

303089
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C18:2, C16:0)

309519
type: LocalParameter
units: 006281
value: 0.0

309517
type: LocalParameter
units: 006281
value: 0.0

309515
type: LocalParameter
units: 006281
value: 1000.0

309513
type: LocalParameter
units: 006281
value: 0.0

303611
type: Reaction
kinetic law: 007384
reactant: 007372
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: K+ exchange

305405
type: LocalParameter
units: 006281
value: 0.0

305402
type: LocalParameter
units: 006281
value: 0.0

305399
type: LocalParameter
units: 006281
value: 10.0

305396
type: LocalParameter
units: 006281
value: -10.0

007372
type: SpeciesReference
stoichiometry: 1.0
species: 303386

302807
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Reduced glutathione

303416
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Sodium

304425
type: Reaction
reactant: 022405
product: 022453
product: 022441
kinetic law: 022465
reversible: true
notes: GENE_ASSOCIATION: Nmnat3.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 022429
reactant: 022417
name: nicotinamide-nucleotide adenylyltransferase
fast: false

022405
type: SpeciesReference
stoichiometry: 1.0
species: 302589

022453
type: SpeciesReference
stoichiometry: 1.0
species: 303143

022441
type: SpeciesReference
stoichiometry: 1.0
species: 302933

308667
type: LocalParameter
units: 006281
value: 0.0

308664
type: LocalParameter
units: 006281
value: 0.0

308661
type: LocalParameter
units: 006281
value: 1000.0

308658
type: LocalParameter
units: 006281
value: -1000.0

022429
type: SpeciesReference
stoichiometry: 1.0
species: 302957

022417
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304635
type: Reaction
product: 026993
reversible: false
kinetic law: 027029
product: 027005
reactant: 026981
fast: false
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-kinase (C18:1,C18:1)
reactant: 026969
product: 027017

026993
type: SpeciesReference
stoichiometry: 1.0
species: 302549

309383
type: LocalParameter
units: 006281
value: 0.0

309381
type: LocalParameter
units: 006281
value: 0.0

309379
type: LocalParameter
units: 006281
value: 1000.0

309377
type: LocalParameter
units: 006281
value: 0.0

027005
type: SpeciesReference
stoichiometry: 1.0
species: 302819

026981
type: SpeciesReference
stoichiometry: 1.0
species: 303062

026969
type: SpeciesReference
stoichiometry: 1.0
species: 302589

027017
type: SpeciesReference
stoichiometry: 1.0
species: 303041

304832
type: Reaction
kinetic law: 031239
product: 031227
reactant: 031214
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Thiamine transprot (passive - red blood cell)

309911
type: LocalParameter
units: 006281
value: 0.0

309909
type: LocalParameter
units: 006281
value: 0.0

309907
type: LocalParameter
units: 006281
value: 1000.0

309905
type: LocalParameter
units: 006281
value: -1000.0

031227
type: SpeciesReference
stoichiometry: 1.0
species: 303203

303203
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Thiamin

031214
type: SpeciesReference
stoichiometry: 1.0
species: 303473

303473
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Thiamin

304590
type: Reaction
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-phosphate phospholipase C (C16:0,C18:2)
reactant: 025964
product: 025988
product: 026012
kinetic law: 026025
fast: false
product: 026000
reversible: false
reactant: 025976

025964
type: SpeciesReference
stoichiometry: 1.0
species: 302822

025988
type: SpeciesReference
stoichiometry: 1.0
species: 302681

302681
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C16:0, C18:2)

026012
type: SpeciesReference
stoichiometry: 1.0
species: 302918

309263
type: LocalParameter
units: 006281
value: 0.0

309261
type: LocalParameter
units: 006281
value: 0.0

309259
type: LocalParameter
units: 006281
value: 1000.0

309257
type: LocalParameter
units: 006281
value: 0.0

026000
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025976
type: SpeciesReference
stoichiometry: 1.0
species: 303038

303038
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C16:0, C18:2)

303821
type: Reaction
kinetic law: 009646
product: 009634
reactant: 009622
notes: GENE_ASSOCIATION: Slc29a2.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: adenine reversible transport, cytosol

306245
type: LocalParameter
units: 006281
value: 0.0

306242
type: LocalParameter
units: 006281
value: 0.0

306239
type: LocalParameter
units: 006281
value: 1000.0

306236
type: LocalParameter
units: 006281
value: -1000.0

009634
type: SpeciesReference
stoichiometry: 1.0
species: 302544

302544
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Adenine

009622
type: SpeciesReference
stoichiometry: 1.0
species: 303278

303278
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Adenine

302570
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidic acid (homo sapiens, C18:2)

303785
type: Reaction
reactant: 008896
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 008970
product: 008920
reversible: false
product: 008932
product: 008945
reactant: 008884
name: 4-Pyridoxal secretion
product: 008957
reactant: 008908
fast: false

008896
type: SpeciesReference
stoichiometry: 1.0
species: 302589

306101
type: LocalParameter
units: 006281
value: 0.0

306098
type: LocalParameter
units: 006281
value: 0.0

306095
type: LocalParameter
units: 006281
value: 1000.0

306092
type: LocalParameter
units: 006281
value: 0.0

008920
type: SpeciesReference
stoichiometry: 1.0
species: 302549

008932
type: SpeciesReference
stoichiometry: 1.0
species: 302819

008945
type: SpeciesReference
stoichiometry: 1.0
species: 303131

008884
type: SpeciesReference
stoichiometry: 1.0
species: 302496

302496
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 4-Pyridoxate

008957
type: SpeciesReference
stoichiometry: 1.0
species: 303263

303263
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 4-Pyridoxate

008908
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304113
type: Reaction
reactant: 015985
product: 016009
fast: false
reactant: 015973
notes: GENE_ASSOCIATION: Acsl1.1 SUBSYSTEM: Fatty acid activation EC Number: Confidence Level: AUTHORS:
kinetic law: 016046
name: fatty-acid--CoA ligase
reactant: 015997
product: 016021
product: 016034
reversible: true

015985
type: SpeciesReference
stoichiometry: 1.0
species: 302660

016009
type: SpeciesReference
stoichiometry: 1.0
species: 302578

015973
type: SpeciesReference
stoichiometry: 1.0
species: 302589

307419
type: LocalParameter
units: 006281
value: 0.0

307416
type: LocalParameter
units: 006281
value: 0.0

307413
type: LocalParameter
units: 006281
value: 1000.0

307410
type: LocalParameter
units: 006281
value: -1000.0

015997
type: SpeciesReference
stoichiometry: 1.0
species: 302873

302873
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: linoleic acid (all cis C18:2) n-6

016021
type: SpeciesReference
stoichiometry: 1.0
species: 302876

302876
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: linoleic coenzyme A

016034
type: SpeciesReference
stoichiometry: 1.0
species: 303143

304608
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 026433
product: 026421
reactant: 026385
fast: false
reactant: 026397
reversible: false
name: phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C18:1)
product: 026409

309311
type: LocalParameter
units: 006281
value: 0.0

309309
type: LocalParameter
units: 006281
value: 0.0

309307
type: LocalParameter
units: 006281
value: 1000.0

309305
type: LocalParameter
units: 006281
value: 0.0

026421
type: SpeciesReference
stoichiometry: 1.0
species: 303131

026385
type: SpeciesReference
stoichiometry: 1.0
species: 302822

026397
type: SpeciesReference
stoichiometry: 1.0
species: 303035

026409
type: SpeciesReference
stoichiometry: 1.0
species: 303056

304805
type: Reaction
reactant: 030683
reversible: false
product: 030708
kinetic law: 030720
name: D-sorbitol reductase
reactant: 030671
fast: false
reactant: 030659
notes: GENE_ASSOCIATION: Akr7a2.1 or Akr1a1.1 or Akr1a1.2 or Akr1b1.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
product: 030695

030683
type: SpeciesReference
stoichiometry: 1.0
species: 302942

030708
type: SpeciesReference
stoichiometry: 1.0
species: 303194

303194
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Sorbitol

309839
type: LocalParameter
units: 006281
value: 0.0

309837
type: LocalParameter
units: 006281
value: 0.0

309835
type: LocalParameter
units: 006281
value: 1000.0

309833
type: LocalParameter
units: 006281
value: 0.0

030671
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030659
type: SpeciesReference
stoichiometry: 1.0
species: 302775

302775
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucose

030695
type: SpeciesReference
stoichiometry: 1.0
species: 302939

304097
type: Reaction
kinetic law: 015620
product: 015608
product: 015596
reactant: 015584
notes: GENE_ASSOCIATION: Eno1.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: enolase

307347
type: LocalParameter
units: 006281
value: 0.0

307344
type: LocalParameter
units: 006281
value: 0.0

307341
type: LocalParameter
units: 006281
value: 1000.0

307338
type: LocalParameter
units: 006281
value: -1000.0

015608
type: SpeciesReference
stoichiometry: 1.0
species: 303119

015596
type: SpeciesReference
stoichiometry: 1.0
species: 302822

015584
type: SpeciesReference
stoichiometry: 1.0
species: 302481

302481
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glycerate 2-phosphate

303164
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxal

304599
type: Reaction
reactant: 026193
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 026205
name: phosphatidylinositol 4-phosphate phospholipase C (C18:2,C16:0)
reactant: 026181
fast: false
product: 026217
kinetic law: 026241
reversible: false
product: 026229

026193
type: SpeciesReference
stoichiometry: 1.0
species: 303047

303047
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:2, C16:0)

026205
type: SpeciesReference
stoichiometry: 1.0
species: 302690

026181
type: SpeciesReference
stoichiometry: 1.0
species: 302822

026217
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309287
type: LocalParameter
units: 006281
value: 0.0

309285
type: LocalParameter
units: 006281
value: 0.0

309283
type: LocalParameter
units: 006281
value: 1000.0

309281
type: LocalParameter
units: 006281
value: 0.0

026229
type: SpeciesReference
stoichiometry: 1.0
species: 302918

304500
type: Reaction
kinetic law: 024078
product: 024066
reactant: 024054
notes: GENE_ASSOCIATION: Gpi.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: glucose-6-phosphate isomerase

308967
type: LocalParameter
units: 006281
value: 0.0

308964
type: LocalParameter
units: 006281
value: 0.0

308961
type: LocalParameter
units: 006281
value: 1000.0

308958
type: LocalParameter
units: 006281
value: -1000.0

024066
type: SpeciesReference
stoichiometry: 1.0
species: 302726

302726
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Fructose 6-phosphate

024054
type: SpeciesReference
stoichiometry: 1.0
species: 302756

302612
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP

303206
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Thiamin monophosphate

304323
type: Reaction
name: carnitine transferase
fast: false
product: 020423
product: 020435
reactant: 020410
kinetic law: 020447
reversible: false
reactant: 020398
notes: GENE_ASSOCIATION: Acsl1.1 SUBSYSTEM: Fatty acid activation EC Number: Confidence Level: AUTHORS:

020423
type: SpeciesReference
stoichiometry: 1.0
species: 302666

020435
type: SpeciesReference
stoichiometry: 1.0
species: 302876

020410
type: SpeciesReference
stoichiometry: 1.0
species: 302879

302879
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Linoleyl carnitine

308259
type: LocalParameter
units: 006281
value: 0.0

308256
type: LocalParameter
units: 006281
value: 0.0

308253
type: LocalParameter
units: 006281
value: 1000.0

308250
type: LocalParameter
units: 006281
value: 0.0

020398
type: SpeciesReference
stoichiometry: 1.0
species: 302660

304034
type: Reaction
notes: GENE_ASSOCIATION: Slc5a7.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: true
name: choline, sodium cotransport
reactant: 014351
kinetic law: 014388
product: 014375
fast: false
reactant: 014339
product: 014363

014351
type: SpeciesReference
stoichiometry: 1.0
species: 303416

307095
type: LocalParameter
units: 006281
value: 0.0

307092
type: LocalParameter
units: 006281
value: 0.0

307089
type: LocalParameter
units: 006281
value: 1000.0

307086
type: LocalParameter
units: 006281
value: -1000.0

014375
type: SpeciesReference
stoichiometry: 1.0
species: 302927

302927
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Sodium

014339
type: SpeciesReference
stoichiometry: 1.0
species: 303305

303305
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Choline

014363
type: SpeciesReference
stoichiometry: 1.0
species: 302642

304251
type: Reaction
kinetic law: 019018
product: 019006
reactant: 018994
notes: GENE_ASSOCIATION: Slc5a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: H2O transport via diffusion

307971
type: LocalParameter
units: 006281
value: 0.0

307968
type: LocalParameter
units: 006281
value: 0.0

307965
type: LocalParameter
units: 006281
value: 1000.0

307962
type: LocalParameter
units: 006281
value: -1000.0

019006
type: SpeciesReference
stoichiometry: 1.0
species: 302822

018994
type: SpeciesReference
stoichiometry: 1.0
species: 303365

304730
type: Reaction
fast: false
reversible: true
reactant: 029064
name: phosphoribosylpyrophosphate synthetase
kinetic law: 029125
product: 029101
notes: GENE_ASSOCIATION: Prps1l1.1 or Prps1l1.2 or Prps1.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
product: 029113
reactant: 029077
product: 029089

029064
type: SpeciesReference
stoichiometry: 1.0
species: 302589

309639
type: LocalParameter
units: 006281
value: 0.0

309637
type: LocalParameter
units: 006281
value: 0.0

309635
type: LocalParameter
units: 006281
value: 1000.0

309633
type: LocalParameter
units: 006281
value: -1000.0

029101
type: SpeciesReference
stoichiometry: 1.0
species: 302819

029113
type: SpeciesReference
stoichiometry: 1.0
species: 303152

029077
type: SpeciesReference
stoichiometry: 1.0
species: 303179

303179
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: alpha-D-Ribose 5-phosphate

029089
type: SpeciesReference
stoichiometry: 1.0
species: 302578

303230
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Uroporphyrinogen III

303755
type: Reaction
kinetic law: 008545
reactant: 008533
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 18 2 18 1(c)

305981
type: LocalParameter
units: 006281
value: 0.0

305978
type: LocalParameter
units: 006281
value: 0.0

305975
type: LocalParameter
units: 006281
value: 10.0

305972
type: LocalParameter
units: 006281
value: -10.0

008533
type: SpeciesReference
stoichiometry: 1.0
species: 303092

303092
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C18:2, C18:1)

303932
type: Reaction
notes: GENE_ASSOCIATION: Abcc4.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
product: 011919
kinetic law: 011943
reactant: 011881
product: 011894
name: cAMP transport (ATP-dependent)
product: 011906
reversible: false
reactant: 011857
fast: false
reactant: 011869
product: 011931

011919
type: SpeciesReference
stoichiometry: 1.0
species: 303131

306689
type: LocalParameter
units: 006281
value: 0.0

306686
type: LocalParameter
units: 006281
value: 0.0

306683
type: LocalParameter
units: 006281
value: 1000.0

306680
type: LocalParameter
units: 006281
value: 0.0

011881
type: SpeciesReference
stoichiometry: 1.0
species: 302822

011894
type: SpeciesReference
stoichiometry: 1.0
species: 302549

011906
type: SpeciesReference
stoichiometry: 1.0
species: 302819

011857
type: SpeciesReference
stoichiometry: 1.0
species: 302589

011869
type: SpeciesReference
stoichiometry: 1.0
species: 302609

011931
type: SpeciesReference
stoichiometry: 1.0
species: 303302

303302
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: cAMP

304569
type: Reaction
name: phosphatidylinositol 4-phosphate 5-kinase (C16:0,C18:2)
product: 025480
reversible: false
kinetic law: 025516
fast: false
reactant: 025456
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 025504
reactant: 025468
product: 025492

025480
type: SpeciesReference
stoichiometry: 1.0
species: 302549

309207
type: LocalParameter
units: 006281
value: 0.0

309205
type: LocalParameter
units: 006281
value: 0.0

309203
type: LocalParameter
units: 006281
value: 1000.0

309201
type: LocalParameter
units: 006281
value: 0.0

025456
type: SpeciesReference
stoichiometry: 1.0
species: 302589

025504
type: SpeciesReference
stoichiometry: 1.0
species: 303017

303017
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C18:2)

025468
type: SpeciesReference
stoichiometry: 1.0
species: 303038

025492
type: SpeciesReference
stoichiometry: 1.0
species: 302819

302951
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinate D-ribonucleoside

304703
type: Reaction
kinetic law: 028594
name: phosphatidic acid phosphatase (C16:0, C18:1)
reversible: false
product: 028570
reactant: 028545
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
fast: false
reactant: 028558
product: 028582

309567
type: LocalParameter
units: 006281
value: 0.0

309565
type: LocalParameter
units: 006281
value: 0.0

309563
type: LocalParameter
units: 006281
value: 1000.0

309561
type: LocalParameter
units: 006281
value: 0.0

028570
type: SpeciesReference
stoichiometry: 1.0
species: 302678

028545
type: SpeciesReference
stoichiometry: 1.0
species: 302822

028558
type: SpeciesReference
stoichiometry: 1.0
species: 302993

302993
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C16:0, C18:1)

028582
type: SpeciesReference
stoichiometry: 1.0
species: 303131

302618
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C16:0, C16:0)

303044
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (homo sapiens, C18:1, C18:2)

303728
type: Reaction
kinetic law: 008328
reactant: 008316
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink mi134p(c)

305873
type: LocalParameter
units: 006281
value: 0.0

305870
type: LocalParameter
units: 006281
value: 0.0

305867
type: LocalParameter
units: 006281
value: 10.0

305864
type: LocalParameter
units: 006281
value: -10.0

008316
type: SpeciesReference
stoichiometry: 1.0
species: 302912

302912
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1,3,4-trisphosphate

304461
type: Reaction
kinetic law: 023268
product: 023256
reactant: 023244
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: o2 transport (diffusion)

308811
type: LocalParameter
units: 006281
value: 0.0

308808
type: LocalParameter
units: 006281
value: 0.0

308805
type: LocalParameter
units: 006281
value: 1000.0

308802
type: LocalParameter
units: 006281
value: -1000.0

023256
type: SpeciesReference
stoichiometry: 1.0
species: 302966

302966
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: O2

023244
type: SpeciesReference
stoichiometry: 1.0
species: 303434

303434
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: O2

302783
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Glutamate

303425
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Ammonium

303620
type: Reaction
kinetic law: 007457
reactant: 007445
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Leukotriene A4 exchange

305441
type: LocalParameter
units: 006281
value: 0.0

305438
type: LocalParameter
units: 006281
value: 0.0

305435
type: LocalParameter
units: 006281
value: 0.0

305432
type: LocalParameter
units: 006281
value: -2.4E-6

007445
type: SpeciesReference
stoichiometry: 1.0
species: 303395

303395
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Leukotriene A4

304004
type: Reaction
product: 013622
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013646
reactant: 013598
product: 013634
name: ethanolamine phosphotransferase (C16:0,C18:1)
reversible: false
kinetic law: 013658
reactant: 013610
fast: false

013622
type: SpeciesReference
stoichiometry: 1.0
species: 302651

013646
type: SpeciesReference
stoichiometry: 1.0
species: 303101

303101
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C16:0, C18:1)

013598
type: SpeciesReference
stoichiometry: 1.0
species: 302639

013634
type: SpeciesReference
stoichiometry: 1.0
species: 302819

306977
type: LocalParameter
units: 006281
value: 0.0

306974
type: LocalParameter
units: 006281
value: 0.0

306971
type: LocalParameter
units: 006281
value: 1000.0

306968
type: LocalParameter
units: 006281
value: 0.0

013610
type: SpeciesReference
stoichiometry: 1.0
species: 302678

304257
type: Reaction
name: bicarbonate transport (Cl-/HCO3- exchange)
kinetic law: 019140
product: 019115
product: 019127
reactant: 019102
reactant: 019090
reversible: true
fast: false
notes: GENE_ASSOCIATION: Slc4a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:

307995
type: LocalParameter
units: 006281
value: 0.0

307992
type: LocalParameter
units: 006281
value: 0.0

307989
type: LocalParameter
units: 006281
value: 1000.0

307986
type: LocalParameter
units: 006281
value: -1000.0

019115
type: SpeciesReference
stoichiometry: 1.0
species: 302828

019127
type: SpeciesReference
stoichiometry: 1.0
species: 303308

019102
type: SpeciesReference
stoichiometry: 1.0
species: 303371

303371
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Bicarbonate

019090
type: SpeciesReference
stoichiometry: 1.0
species: 302648

303359
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Oxidized glutathione

304434
type: Reaction
fast: false
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 022669
product: 022681
reactant: 022645
name: nucleotide phosphatase
kinetic law: 022705
product: 022693
reactant: 022657

022669
type: SpeciesReference
stoichiometry: 1.0
species: 303176

022681
type: SpeciesReference
stoichiometry: 1.0
species: 302951

022645
type: SpeciesReference
stoichiometry: 1.0
species: 302819

308703
type: LocalParameter
units: 006281
value: 0.0

308700
type: LocalParameter
units: 006281
value: 0.0

308697
type: LocalParameter
units: 006281
value: 1000.0

308694
type: LocalParameter
units: 006281
value: 0.0

022693
type: SpeciesReference
stoichiometry: 1.0
species: 303131

022657
type: SpeciesReference
stoichiometry: 1.0
species: 302930

302930
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinate

303938
type: Reaction
reactant: 012015
product: 012027
name: phosphatidylinositol synthase (Homo sapiens, C16:0, C16:0)
fast: false
product: 012039
product: 012051
reactant: 012003
kinetic law: 012064
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: true

012015
type: SpeciesReference
stoichiometry: 1.0
species: 302849

012027
type: SpeciesReference
stoichiometry: 1.0
species: 302651

012039
type: SpeciesReference
stoichiometry: 1.0
species: 302819

012051
type: SpeciesReference
stoichiometry: 1.0
species: 303053

303053
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C16:0, C16:0)

012003
type: SpeciesReference
stoichiometry: 1.0
species: 302618

306713
type: LocalParameter
units: 006281
value: 0.0

306710
type: LocalParameter
units: 006281
value: 0.0

306707
type: LocalParameter
units: 006281
value: 1000.0

306704
type: LocalParameter
units: 006281
value: -1000.0

304644
type: Reaction
reactant: 027186
product: 027211
kinetic law: 027247
reversible: false
product: 027223
name: phosphatidylinositol 4-kinase (C18:2,C18 1)
fast: false
product: 027235
reactant: 027199
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:

027186
type: SpeciesReference
stoichiometry: 1.0
species: 302589

027211
type: SpeciesReference
stoichiometry: 1.0
species: 302549

309407
type: LocalParameter
units: 006281
value: 0.0

309405
type: LocalParameter
units: 006281
value: 0.0

309403
type: LocalParameter
units: 006281
value: 1000.0

309401
type: LocalParameter
units: 006281
value: 0.0

027223
type: SpeciesReference
stoichiometry: 1.0
species: 302819

027235
type: SpeciesReference
stoichiometry: 1.0
species: 303050

027199
type: SpeciesReference
stoichiometry: 1.0
species: 303071

303071
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C18:2, C18:1)

304841
type: Reaction
reactant: 031385
notes: GENE_ASSOCIATION: Tpk1.1 SUBSYSTEM: Thiamine Metabolism EC Number: Confidence Level: AUTHORS:
name: thiamine diphosphokinase
kinetic law: 031433
product: 031397
reactant: 031373
product: 031409
reversible: false
fast: false
product: 031421

031385
type: SpeciesReference
stoichiometry: 1.0
species: 303203

309935
type: LocalParameter
units: 006281
value: 0.0

309933
type: LocalParameter
units: 006281
value: 0.0

309931
type: LocalParameter
units: 006281
value: 1000.0

309929
type: LocalParameter
units: 006281
value: 0.0

031397
type: SpeciesReference
stoichiometry: 1.0
species: 302578

031373
type: SpeciesReference
stoichiometry: 1.0
species: 302589

031409
type: SpeciesReference
stoichiometry: 1.0
species: 302819

031421
type: SpeciesReference
stoichiometry: 1.0
species: 303209

303866
type: Reaction
reversible: false
product: 010489
fast: false
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
product: 010477
reactant: 010464
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:2,C18:1)
reactant: 010451
kinetic law: 010501

010489
type: SpeciesReference
stoichiometry: 1.0
species: 303008

303008
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C18:2, C18:1)

010477
type: SpeciesReference
stoichiometry: 1.0
species: 302660

010464
type: SpeciesReference
stoichiometry: 1.0
species: 302975

010451
type: SpeciesReference
stoichiometry: 1.0
species: 302570

306425
type: LocalParameter
units: 006281
value: 0.0

306422
type: LocalParameter
units: 006281
value: 0.0

306419
type: LocalParameter
units: 006281
value: 1000.0

306416
type: LocalParameter
units: 006281
value: 0.0

303893
type: Reaction
kinetic law: 011095
product: 011083
reactant: 011070
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-arginine transport via diffusion

306533
type: LocalParameter
units: 006281
value: 0.0

306530
type: LocalParameter
units: 006281
value: 0.0

306527
type: LocalParameter
units: 006281
value: 1000.0

306524
type: LocalParameter
units: 006281
value: -1000.0

011083
type: SpeciesReference
stoichiometry: 1.0
species: 302583

011070
type: SpeciesReference
stoichiometry: 1.0
species: 303290

303290
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Arginine

302717
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Ethanolamine

303830
type: Reaction
kinetic law: 009812
product: 009800
product: 009788
reactant: 009776
notes: GENE_ASSOCIATION: Adcy6.2 or Adcy6.1 or Adcy5.1 or Adcy4.1 or Adcy7.1 or Adcy2.1 or Adcy3.1 or Adcy1.1 or Adcy8.1 or Adcy9.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: adenylate cyclase

306281
type: LocalParameter
units: 006281
value: 0.0

306278
type: LocalParameter
units: 006281
value: 0.0

306275
type: LocalParameter
units: 006281
value: 1000.0

306272
type: LocalParameter
units: 006281
value: 0.0

009800
type: SpeciesReference
stoichiometry: 1.0
species: 303143

009788
type: SpeciesReference
stoichiometry: 1.0
species: 302609

009776
type: SpeciesReference
stoichiometry: 1.0
species: 302589

304122
type: Reaction
notes: GENE_ASSOCIATION: Pfkfb4.1 or Pfkfb1.1 or Pfkfb3.1 or Pfkfb2.1 or Fbp2.1 or Fbp1.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 016190
fast: false
product: 016202
reversible: false
name: Fructose-2,6-bisphosphate 2-phosphatase
reactant: 016178
product: 016214
kinetic law: 016226

016190
type: SpeciesReference
stoichiometry: 1.0
species: 302822

016202
type: SpeciesReference
stoichiometry: 1.0
species: 302726

016178
type: SpeciesReference
stoichiometry: 1.0
species: 302723

302723
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Fructose 2,6-bisphosphate

016214
type: SpeciesReference
stoichiometry: 1.0
species: 303131

307455
type: LocalParameter
units: 006281
value: 0.0

307452
type: LocalParameter
units: 006281
value: 0.0

307449
type: LocalParameter
units: 006281
value: 1000.0

307446
type: LocalParameter
units: 006281
value: 0.0

304395
type: Reaction
reactant: 021762
reactant: 021750
fast: false
product: 021786
product: 021798
notes: GENE_ASSOCIATION: Nadk.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 021774
kinetic law: 021810
name: NAD kinase

021762
type: SpeciesReference
stoichiometry: 1.0
species: 302933

021750
type: SpeciesReference
stoichiometry: 1.0
species: 302589

021786
type: SpeciesReference
stoichiometry: 1.0
species: 302819

021798
type: SpeciesReference
stoichiometry: 1.0
species: 302939

021774
type: SpeciesReference
stoichiometry: 1.0
species: 302549

308547
type: LocalParameter
units: 006281
value: 0.0

308544
type: LocalParameter
units: 006281
value: 0.0

308541
type: LocalParameter
units: 006281
value: 1000.0

308538
type: LocalParameter
units: 006281
value: 0.0

303626
type: Reaction
kinetic law: 007505
reactant: 007493
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: linoleic acid (all cis C18:2) exchange

305465
type: LocalParameter
units: 006281
value: 0.0

305462
type: LocalParameter
units: 006281
value: 0.0

305459
type: LocalParameter
units: 006281
value: 0.0

305456
type: LocalParameter
units: 006281
value: -0.006

007493
type: SpeciesReference
stoichiometry: 1.0
species: 303401

303401
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: linoleic acid (all cis C18:2) n-6

303581
type: Reaction
kinetic law: 007142
reactant: 007130
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Glycerol exchange

305285
type: LocalParameter
units: 006281
value: 0.0

305282
type: LocalParameter
units: 006281
value: 0.0

305279
type: LocalParameter
units: 006281
value: 0.0

305276
type: LocalParameter
units: 006281
value: -0.012

007130
type: SpeciesReference
stoichiometry: 1.0
species: 303356

303356
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Glycerol

304368
type: Reaction
kinetic law: 021316
product: 021304
product: 021292
reactant: 021280
notes: GENE_ASSOCIATION: SUBSYSTEM: Pyruvate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: methylglyoxal synthase

308439
type: LocalParameter
units: 006281
value: 0.0

308436
type: LocalParameter
units: 006281
value: 0.0

308433
type: LocalParameter
units: 006281
value: 1000.0

308430
type: LocalParameter
units: 006281
value: 0.0

021304
type: SpeciesReference
stoichiometry: 1.0
species: 303131

021292
type: SpeciesReference
stoichiometry: 1.0
species: 302924

302924
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Methylglyoxal

021280
type: SpeciesReference
stoichiometry: 1.0
species: 302696

302696
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Dihydroxyacetone phosphate

303182
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Riboflavin

304847
type: Reaction
kinetic law: 031529
product: 031517
reactant: 031505
notes: GENE_ASSOCIATION: Tpi1.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: triose-phosphate isomerase

309951
type: LocalParameter
units: 006281
value: 0.0

309949
type: LocalParameter
units: 006281
value: 0.0

309947
type: LocalParameter
units: 006281
value: 1000.0

309945
type: LocalParameter
units: 006281
value: -1000.0

031517
type: SpeciesReference
stoichiometry: 1.0
species: 302751

302751
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Glyceraldehyde 3-phosphate

031505
type: SpeciesReference
stoichiometry: 1.0
species: 302696

303149
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Protoporphyrinogen IX

303554
type: Reaction
kinetic law: 006922
reactant: 006910
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Fe2+ exchange

305177
type: LocalParameter
units: 006281
value: 0.0

305174
type: LocalParameter
units: 006281
value: 0.0

305171
type: LocalParameter
units: 006281
value: 10.0

305168
type: LocalParameter
units: 006281
value: -10.0

006910
type: SpeciesReference
stoichiometry: 1.0
species: 303329

303329
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Fe2+

302840
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Hypoxanthine

303020
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:1, C18:1)

303764
type: Reaction
kinetic law: 008617
reactant: 008605
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pe hs 16 0 18 2(c)

306017
type: LocalParameter
units: 006281
value: 0.0

306014
type: LocalParameter
units: 006281
value: 0.0

306011
type: LocalParameter
units: 006281
value: 10.0

306008
type: LocalParameter
units: 006281
value: -10.0

008605
type: SpeciesReference
stoichiometry: 1.0
species: 303104

303104
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C16:0, C18:2)

303791
type: Reaction
kinetic law: 009066
product: 009054
reactant: 009042
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: acetaldehyde reversible transport

306125
type: LocalParameter
units: 006281
value: 0.0

306122
type: LocalParameter
units: 006281
value: 0.0

306119
type: LocalParameter
units: 006281
value: 1000.0

306116
type: LocalParameter
units: 006281
value: -1000.0

009054
type: SpeciesReference
stoichiometry: 1.0
species: 302523

302523
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Acetaldehyde

009042
type: SpeciesReference
stoichiometry: 1.0
species: 303272

303272
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Acetaldehyde

304128
type: Reaction
kinetic law: 016323
product: 016310
reactant: 016298
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: iron (II) transport

307479
type: LocalParameter
units: 006281
value: 0.0

307476
type: LocalParameter
units: 006281
value: 0.0

307473
type: LocalParameter
units: 006281
value: 1000.0

307470
type: LocalParameter
units: 006281
value: -1000.0

016310
type: SpeciesReference
stoichiometry: 1.0
species: 302733

016298
type: SpeciesReference
stoichiometry: 1.0
species: 303329

303443
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Phenylalanine

304578
type: Reaction
reactant: 025685
fast: false
kinetic law: 025734
product: 025698
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 025710
name: phosphatidylinositol 4-phosphate 5-kinase (C18:2,C16:0)
product: 025722
reversible: false
reactant: 025673

025685
type: SpeciesReference
stoichiometry: 1.0
species: 303047

309231
type: LocalParameter
units: 006281
value: 0.0

309229
type: LocalParameter
units: 006281
value: 0.0

309227
type: LocalParameter
units: 006281
value: 1000.0

309225
type: LocalParameter
units: 006281
value: 0.0

025698
type: SpeciesReference
stoichiometry: 1.0
species: 302549

025710
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025722
type: SpeciesReference
stoichiometry: 1.0
species: 303026

303026
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:2, C16:0)

025673
type: SpeciesReference
stoichiometry: 1.0
species: 302589

304775
type: Reaction
notes: GENE_ASSOCIATION: Slc16a1.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 029973
fast: false
kinetic law: 030021
reactant: 029985
product: 029997
product: 030009
name: pyruvate reversible transport via proton symport
reversible: true

029973
type: SpeciesReference
stoichiometry: 1.0
species: 303362

309759
type: LocalParameter
units: 006281
value: 0.0

309757
type: LocalParameter
units: 006281
value: 0.0

309755
type: LocalParameter
units: 006281
value: 1000.0

309753
type: LocalParameter
units: 006281
value: -1000.0

029985
type: SpeciesReference
stoichiometry: 1.0
species: 303461

303461
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Pyruvate

029997
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030009
type: SpeciesReference
stoichiometry: 1.0
species: 303173

304040
type: Reaction
kinetic law: 014460
product: 014448
reactant: 014436
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: CO transporter via diffusion

307119
type: LocalParameter
units: 006281
value: 0.0

307116
type: LocalParameter
units: 006281
value: 0.0

307113
type: LocalParameter
units: 006281
value: 1000.0

307110
type: LocalParameter
units: 006281
value: -1000.0

014448
type: SpeciesReference
stoichiometry: 1.0
species: 303311

303311
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Carbon monoxide

014436
type: SpeciesReference
stoichiometry: 1.0
species: 302654

304293
type: Reaction
product: 019880
product: 019855
name: isocitrate dehydrogenase (NADP)
product: 019868
fast: false
reactant: 019843
reactant: 019831
reversible: false
kinetic law: 019893
notes: GENE_ASSOCIATION: Idh1.1 SUBSYSTEM: Citric Acid Cycle EC Number: Confidence Level: AUTHORS:

019880
type: SpeciesReference
stoichiometry: 1.0
species: 302942

019855
type: SpeciesReference
stoichiometry: 1.0
species: 302558

302558
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 2-Oxoglutarate

019868
type: SpeciesReference
stoichiometry: 1.0
species: 302657

019843
type: SpeciesReference
stoichiometry: 1.0
species: 302939

019831
type: SpeciesReference
stoichiometry: 1.0
species: 302843

302843
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Isocitrate

308139
type: LocalParameter
units: 006281
value: 0.0

308136
type: LocalParameter
units: 006281
value: 0.0

308133
type: LocalParameter
units: 006281
value: 1000.0

308130
type: LocalParameter
units: 006281
value: 0.0

304470
type: Reaction
product: 023438
notes: GENE_ASSOCIATION: Oplah.1 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 023378
product: 023414
reversible: false
reactant: 023390
product: 023426
kinetic law: 023462
product: 023450
name: 5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)
fast: false
reactant: 023402

023438
type: SpeciesReference
stoichiometry: 1.0
species: 302819

023378
type: SpeciesReference
stoichiometry: 1.0
species: 302511

302511
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Oxoproline

023414
type: SpeciesReference
stoichiometry: 1.0
species: 302549

023390
type: SpeciesReference
stoichiometry: 1.0
species: 302589

023426
type: SpeciesReference
stoichiometry: 1.0
species: 302783

308847
type: LocalParameter
units: 006281
value: 0.0

308844
type: LocalParameter
units: 006281
value: 0.0

308841
type: LocalParameter
units: 006281
value: 1000.0

308838
type: LocalParameter
units: 006281
value: 0.0

023450
type: SpeciesReference
stoichiometry: 1.0
species: 303131

023402
type: SpeciesReference
stoichiometry: 2.0
species: 302822

303215
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UDP

304013
type: Reaction
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013850
product: 013862
reversible: false
kinetic law: 013874
reactant: 013826
product: 013838
name: ethanolamine phosphotransferase (C18:1,C18:2)
fast: false
reactant: 013814

013850
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013862
type: SpeciesReference
stoichiometry: 1.0
species: 303110

307013
type: LocalParameter
units: 006281
value: 0.0

307010
type: LocalParameter
units: 006281
value: 0.0

307007
type: LocalParameter
units: 006281
value: 1000.0

307004
type: LocalParameter
units: 006281
value: 0.0

013826
type: SpeciesReference
stoichiometry: 1.0
species: 302687

302687
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C18:1, C18:2)

013838
type: SpeciesReference
stoichiometry: 1.0
species: 302651

013814
type: SpeciesReference
stoichiometry: 1.0
species: 302639

303167
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxal 5'-phosphate

304266
type: Reaction
name: hexokinase (D-glucose:ATP)
product: 019250
kinetic law: 019286
product: 019274
reactant: 019238
notes: GENE_ASSOCIATION: Hk2.1 or Hk1.3 or Hk1.1 or Hk1.2 or Hk3.1 or Flj22761.1 or Hk1.4 or Hk1.5 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
product: 019262
fast: false
reversible: false
reactant: 019226

019250
type: SpeciesReference
stoichiometry: 1.0
species: 302549

308031
type: LocalParameter
units: 006281
value: 0.0

308028
type: LocalParameter
units: 006281
value: 0.0

308025
type: LocalParameter
units: 006281
value: 1000.0

308022
type: LocalParameter
units: 006281
value: 0.0

019274
type: SpeciesReference
stoichiometry: 1.0
species: 302819

019238
type: SpeciesReference
stoichiometry: 1.0
species: 302775

019262
type: SpeciesReference
stoichiometry: 1.0
species: 302756

019226
type: SpeciesReference
stoichiometry: 1.0
species: 302589

303911
type: Reaction
reversible: false
reactant: 011436
fast: false
product: 011449
kinetic law: 011473
notes: GENE_ASSOCIATION: Blvra.1 SUBSYSTEM: Heme Degradation EC Number: Confidence Level: AUTHORS:
product: 011461
reactant: 011424
name: Nad(p)h biliverdin reductase
reactant: 011412

011436
type: SpeciesReference
stoichiometry: 1.0
species: 302942

011449
type: SpeciesReference
stoichiometry: 1.0
species: 302600

302600
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Bilirubin

306605
type: LocalParameter
units: 006281
value: 0.0

306602
type: LocalParameter
units: 006281
value: 0.0

306599
type: LocalParameter
units: 006281
value: 1000.0

306596
type: LocalParameter
units: 006281
value: 0.0

011461
type: SpeciesReference
stoichiometry: 1.0
species: 302939

011424
type: SpeciesReference
stoichiometry: 1.0
species: 302819

011412
type: SpeciesReference
stoichiometry: 1.0
species: 302603

302603
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Biliverdin

302999
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C18:1, C18:1)

304440
type: Reaction
product: 022789
fast: false
reactant: 022765
reactant: 022753
name: 5'-nucleotidase
notes: GENE_ASSOCIATION: Nt5C2.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 022801
product: 022777
reversible: false

022789
type: SpeciesReference
stoichiometry: 1.0
species: 303131

022765
type: SpeciesReference
stoichiometry: 1.0
species: 302954

302954
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinate D-ribonucleotide

022753
type: SpeciesReference
stoichiometry: 1.0
species: 302822

308727
type: LocalParameter
units: 006281
value: 0.0

308724
type: LocalParameter
units: 006281
value: 0.0

308721
type: LocalParameter
units: 006281
value: 1000.0

308718
type: LocalParameter
units: 006281
value: 0.0

022777
type: SpeciesReference
stoichiometry: 1.0
species: 302951

302564
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidic acid (homo sapiens, C16:0)

303233
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Urea

303698
type: Reaction
kinetic law: 008086
reactant: 008074
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Thiamin exchange

305753
type: LocalParameter
units: 006281
value: 0.0

305750
type: LocalParameter
units: 006281
value: 0.0

305747
type: LocalParameter
units: 006281
value: 0.0

305744
type: LocalParameter
units: 006281
value: -6.0E-5

008074
type: SpeciesReference
stoichiometry: 1.0
species: 303473

303590
type: Reaction
kinetic law: 007215
reactant: 007203
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: H2O exchange

305321
type: LocalParameter
units: 006281
value: 0.0

305318
type: LocalParameter
units: 006281
value: 0.0

305315
type: LocalParameter
units: 006281
value: 10.0

305312
type: LocalParameter
units: 006281
value: -6.45680282666678

007203
type: SpeciesReference
stoichiometry: 1.0
species: 303365

304019
type: Reaction
reactant: 013971
fast: false
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
name: ethanolamine phosphotransferase (C18:2,C18:1)
product: 013984
product: 013997
reactant: 013959
product: 014010
kinetic law: 014023

013971
type: SpeciesReference
stoichiometry: 1.0
species: 302693

302693
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: diacylglycerol (homo sapiens, C18:2, C18:1)

013984
type: SpeciesReference
stoichiometry: 1.0
species: 302651

013997
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013959
type: SpeciesReference
stoichiometry: 1.0
species: 302639

014010
type: SpeciesReference
stoichiometry: 1.0
species: 303116

307037
type: LocalParameter
units: 006281
value: 0.0

307034
type: LocalParameter
units: 006281
value: 0.0

307031
type: LocalParameter
units: 006281
value: 1000.0

307028
type: LocalParameter
units: 006281
value: 0.0

304413
type: Reaction
kinetic law: 022198
reactant: 022162
name: nucleoside-diphosphate kinase (ATP:UDP)
fast: false
notes: GENE_ASSOCIATION: NME3.1 or NME6.1 or NME7.2 or NME7.1 or NME12.2 or NME12.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
product: 022174
reversible: true
reactant: 022150
product: 022186

308619
type: LocalParameter
units: 006281
value: 0.0

308616
type: LocalParameter
units: 006281
value: 0.0

308613
type: LocalParameter
units: 006281
value: 1000.0

308610
type: LocalParameter
units: 006281
value: -1000.0

022162
type: SpeciesReference
stoichiometry: 1.0
species: 303215

022174
type: SpeciesReference
stoichiometry: 1.0
species: 302549

022150
type: SpeciesReference
stoichiometry: 1.0
species: 302589

022186
type: SpeciesReference
stoichiometry: 1.0
species: 303239

303239
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: UTP

303917
type: Reaction
notes: GENE_ASSOCIATION: Cpt2.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
product: 011581
reversible: false
reactant: 011557
name: C160 reverse
reactant: 011545
product: 011569
fast: false
kinetic law: 011593

011581
type: SpeciesReference
stoichiometry: 1.0
species: 303134

303134
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Palmitoyl-CoA (n-C16:0CoA)

011557
type: SpeciesReference
stoichiometry: 1.0
species: 303137

303137
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Palmitoylcarnitine

011545
type: SpeciesReference
stoichiometry: 1.0
species: 302660

011569
type: SpeciesReference
stoichiometry: 1.0
species: 302666

306629
type: LocalParameter
units: 006281
value: 0.0

306626
type: LocalParameter
units: 006281
value: 0.0

306623
type: LocalParameter
units: 006281
value: 1000.0

306620
type: LocalParameter
units: 006281
value: 0.0

304623
type: Reaction
name: phosphatidylinositol-4-phosphate 4-phosphatase (C18:2,C18:1)
product: 026715
reversible: false
kinetic law: 026740
fast: false
reactant: 026691
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 026727
reactant: 026703

026715
type: SpeciesReference
stoichiometry: 1.0
species: 303071

309351
type: LocalParameter
units: 006281
value: 0.0

309349
type: LocalParameter
units: 006281
value: 0.0

309347
type: LocalParameter
units: 006281
value: 1000.0

309345
type: LocalParameter
units: 006281
value: 0.0

026691
type: SpeciesReference
stoichiometry: 1.0
species: 302822

026727
type: SpeciesReference
stoichiometry: 1.0
species: 303131

026703
type: SpeciesReference
stoichiometry: 1.0
species: 303050

304820
type: Reaction
reactant: 030972
notes: GENE_ASSOCIATION: Taldo1.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
product: 030996
name: transaldolase
fast: false
reversible: true
reactant: 030984
product: 031008
kinetic law: 031020

030972
type: SpeciesReference
stoichiometry: 1.0
species: 302751

030996
type: SpeciesReference
stoichiometry: 1.0
species: 302714

302714
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Erythrose 4-phosphate

030984
type: SpeciesReference
stoichiometry: 1.0
species: 303191

303191
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Sedoheptulose 7-phosphate

031008
type: SpeciesReference
stoichiometry: 1.0
species: 302726

309879
type: LocalParameter
units: 006281
value: 0.0

309877
type: LocalParameter
units: 006281
value: 0.0

309875
type: LocalParameter
units: 006281
value: 1000.0

309873
type: LocalParameter
units: 006281
value: -1000.0

304419
type: Reaction
product: 022296
reactant: 022272
reactant: 022284
fast: false
kinetic law: 022320
notes: GENE_ASSOCIATION: Rhbg.1-e or Rhag.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: true
product: 022308
name: ammonia transport via proton antiport

022296
type: SpeciesReference
stoichiometry: 1.0
species: 302819

022272
type: SpeciesReference
stoichiometry: 1.0
species: 302948

022284
type: SpeciesReference
stoichiometry: 1.0
species: 303362

308643
type: LocalParameter
units: 006281
value: 0.0

308640
type: LocalParameter
units: 006281
value: 0.0

308637
type: LocalParameter
units: 006281
value: 1000.0

308634
type: LocalParameter
units: 006281
value: -1000.0

022308
type: SpeciesReference
stoichiometry: 1.0
species: 303425

302556
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: S-Adenosyl-L-homocysteine

304101
type: Reaction
kinetic law: 015730
product: 015718
reactant: 015706
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: ethanolamine transport via diffusion (extracellular)

307371
type: LocalParameter
units: 006281
value: 0.0

307368
type: LocalParameter
units: 006281
value: 0.0

307365
type: LocalParameter
units: 006281
value: 1000.0

307362
type: LocalParameter
units: 006281
value: -1000.0

015718
type: SpeciesReference
stoichiometry: 1.0
species: 302717

015706
type: SpeciesReference
stoichiometry: 1.0
species: 303326

303326
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Ethanolamine

304085
type: Reaction
fast: false
notes: GENE_ASSOCIATION: Comt.1 or Comt.2 SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 015427
reactant: 015379
product: 015403
product: 015391
product: 015415
reversible: false
name: Dopamine:amet O-methyltransferase
reactant: 015367

307299
type: LocalParameter
units: 006281
value: 0.0

307296
type: LocalParameter
units: 006281
value: 0.0

307293
type: LocalParameter
units: 006281
value: 1000.0

307290
type: LocalParameter
units: 006281
value: 0.0

015379
type: SpeciesReference
stoichiometry: 1.0
species: 302711

302711
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Dopamine

015403
type: SpeciesReference
stoichiometry: 1.0
species: 302556

015391
type: SpeciesReference
stoichiometry: 1.0
species: 302490

302490
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3-Methoxytyramine

015415
type: SpeciesReference
stoichiometry: 1.0
species: 302819

015367
type: SpeciesReference
stoichiometry: 1.0
species: 302572

302572
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: S-Adenosyl-L-methionine

303605
type: Reaction
kinetic law: 007336
reactant: 007324
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Hypoxanthine exchange

305381
type: LocalParameter
units: 006281
value: 0.0

305378
type: LocalParameter
units: 006281
value: 0.0

305375
type: LocalParameter
units: 006281
value: 0.024

305372
type: LocalParameter
units: 006281
value: 0.0

007324
type: SpeciesReference
stoichiometry: 1.0
species: 303380

303380
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Hypoxanthine

303569
type: Reaction
kinetic law: 007044
reactant: 007032
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-Glucose exchange

305237
type: LocalParameter
units: 006281
value: 0.0

305234
type: LocalParameter
units: 006281
value: 0.0

305231
type: LocalParameter
units: 006281
value: 0.0

305228
type: LocalParameter
units: 006281
value: -1.12

007032
type: SpeciesReference
stoichiometry: 1.0
species: 303344

303344
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Glucose

303596
type: Reaction
kinetic law: 007263
reactant: 007251
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Bicarbonate exchange

305345
type: LocalParameter
units: 006281
value: 0.0

305342
type: LocalParameter
units: 006281
value: 0.0

305339
type: LocalParameter
units: 006281
value: 5.87112293333346

305336
type: LocalParameter
units: 006281
value: -0.0824999999999996

007251
type: SpeciesReference
stoichiometry: 1.0
species: 303371

304826
type: Reaction
kinetic law: 031129
product: 031117
reactant: 031105
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Thiamine monophosphate transport (passive - red blood cell)

309895
type: LocalParameter
units: 006281
value: 0.0

309893
type: LocalParameter
units: 006281
value: 0.0

309891
type: LocalParameter
units: 006281
value: 1000.0

309889
type: LocalParameter
units: 006281
value: -1000.0

031117
type: SpeciesReference
stoichiometry: 1.0
species: 303206

031105
type: SpeciesReference
stoichiometry: 1.0
species: 303476

303476
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Thiamin monophosphate

304311
type: Reaction
kinetic law: 020242
product: 020230
reactant: 020218
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: leukotriene A4 transmembrane (homo sapiens) transport

308211
type: LocalParameter
units: 006281
value: 0.0

308208
type: LocalParameter
units: 006281
value: 0.0

308205
type: LocalParameter
units: 006281
value: 1000.0

308202
type: LocalParameter
units: 006281
value: -1000.0

020230
type: SpeciesReference
stoichiometry: 1.0
species: 302864

302864
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Leukotriene A4

020218
type: SpeciesReference
stoichiometry: 1.0
species: 303395

304098
type: Reaction
name: Ethanolamine kinase
notes: GENE_ASSOCIATION: Etnk2 or Etnk1 or Chk.1 or Chk.2 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 015682
product: 015658
reactant: 015633
reactant: 015645
kinetic law: 015694
reversible: false
product: 015670
fast: false

015682
type: SpeciesReference
stoichiometry: 1.0
species: 302819

015658
type: SpeciesReference
stoichiometry: 1.0
species: 302549

015633
type: SpeciesReference
stoichiometry: 1.0
species: 302589

015645
type: SpeciesReference
stoichiometry: 1.0
species: 302717

307359
type: LocalParameter
units: 006281
value: 0.0

307356
type: LocalParameter
units: 006281
value: 0.0

307353
type: LocalParameter
units: 006281
value: 1000.0

307350
type: LocalParameter
units: 006281
value: 0.0

015670
type: SpeciesReference
stoichiometry: 1.0
species: 302720

302720
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Ethanolamine phosphate

303293
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Ascorbate

303743
type: Reaction
kinetic law: 008449
reactant: 008437
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 16 0 18 2(c)

305933
type: LocalParameter
units: 006281
value: 0.0

305930
type: LocalParameter
units: 006281
value: 0.0

305927
type: LocalParameter
units: 006281
value: 10.0

305924
type: LocalParameter
units: 006281
value: -10.0

008437
type: SpeciesReference
stoichiometry: 1.0
species: 303080

303080
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C16:0, C18:2)

304107
type: Reaction
notes: GENE_ASSOCIATION: Acsl1.1 SUBSYSTEM: Fatty acid activation EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 015815
fast: false
kinetic law: 015876
product: 015839
product: 015864
reactant: 015827
name: fatty-acid--CoA ligase (hexadecanoate)
reactant: 015803
product: 015852

015815
type: SpeciesReference
stoichiometry: 1.0
species: 302660

307395
type: LocalParameter
units: 006281
value: 0.0

307392
type: LocalParameter
units: 006281
value: 0.0

307389
type: LocalParameter
units: 006281
value: 1000.0

307386
type: LocalParameter
units: 006281
value: -1000.0

015839
type: SpeciesReference
stoichiometry: 1.0
species: 302578

015864
type: SpeciesReference
stoichiometry: 1.0
species: 303143

015827
type: SpeciesReference
stoichiometry: 1.0
species: 302834

015803
type: SpeciesReference
stoichiometry: 1.0
species: 302589

015852
type: SpeciesReference
stoichiometry: 1.0
species: 303134

304557
type: Reaction
reactant: 025167
product: 025203
product: 025191
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 025215
reactant: 025179
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:2, C16:0)
kinetic law: 025227
fast: false

025167
type: SpeciesReference
stoichiometry: 1.0
species: 302822

025203
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025191
type: SpeciesReference
stoichiometry: 1.0
species: 302690

025215
type: SpeciesReference
stoichiometry: 1.0
species: 302915

302915
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1D-myo-Inositol 1,4,5-trisphosphate

025179
type: SpeciesReference
stoichiometry: 1.0
species: 303026

309175
type: LocalParameter
units: 006281
value: 0.0

309173
type: LocalParameter
units: 006281
value: 0.0

309171
type: LocalParameter
units: 006281
value: 1000.0

309169
type: LocalParameter
units: 006281
value: 0.0

303539
type: Reaction
kinetic law: 006802
reactant: 006789
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: CO2 exchange

305120
type: LocalParameter
units: 006281
value: 0.0

305117
type: LocalParameter
units: 006281
value: 0.0

305114
type: LocalParameter
units: 006281
value: 5.33854219999983

305111
type: LocalParameter
units: 006281
value: -5.87112293333346

006789
type: SpeciesReference
stoichiometry: 1.0
species: 303314

303314
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: CO2

303716
type: Reaction
kinetic law: 008232
reactant: 008219
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink band(c)

305825
type: LocalParameter
units: 006281
value: 0.0

305822
type: LocalParameter
units: 006281
value: 0.0

305819
type: LocalParameter
units: 006281
value: 10.0

305816
type: LocalParameter
units: 006281
value: -10.0

008219
type: SpeciesReference
stoichiometry: 1.0
species: 302591

302591
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Band membrane protein (universal, erythrocyte -> 2.1,3,4.1)

302502
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate

303953
type: Reaction
reactant: 012366
product: 012390
reversible: true
product: 012402
kinetic law: 012426
reactant: 012378
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
name: phosphatidylinositol synthase (Homo sapiens, C18:2,C16:0)
product: 012414

012366
type: SpeciesReference
stoichiometry: 1.0
species: 302633

302633
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C18:2, C16:0)

012390
type: SpeciesReference
stoichiometry: 1.0
species: 302651

012402
type: SpeciesReference
stoichiometry: 1.0
species: 302819

306773
type: LocalParameter
units: 006281
value: 0.0

306770
type: LocalParameter
units: 006281
value: 0.0

306767
type: LocalParameter
units: 006281
value: 1000.0

306764
type: LocalParameter
units: 006281
value: -1000.0

012378
type: SpeciesReference
stoichiometry: 1.0
species: 302849

012414
type: SpeciesReference
stoichiometry: 1.0
species: 303068

303068
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C18:2, C16:0)

304245
type: Reaction
reactant: 018897
reversible: true
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
reactant: 018909
reactant: 018885
name: gulonate dehydrogenase
product: 018934
product: 018921
fast: false
kinetic law: 018946

018897
type: SpeciesReference
stoichiometry: 1.0
species: 302819

018909
type: SpeciesReference
stoichiometry: 1.0
species: 302942

018885
type: SpeciesReference
stoichiometry: 1.0
species: 302778

302778
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucuronate

018934
type: SpeciesReference
stoichiometry: 1.0
species: 302939

018921
type: SpeciesReference
stoichiometry: 1.0
species: 302816

302816
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Gulonate

307947
type: LocalParameter
units: 006281
value: 0.0

307944
type: LocalParameter
units: 006281
value: 0.0

307941
type: LocalParameter
units: 006281
value: 1000.0

307938
type: LocalParameter
units: 006281
value: -1000.0

303323
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Dopamine

303926
type: Reaction
kinetic law: 011749
product: 011737
reactant: 011725
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: calcium (Ca+2) transport via diffusion (extracellular to periplasm)

306665
type: LocalParameter
units: 006281
value: 0.0

306662
type: LocalParameter
units: 006281
value: 0.0

306659
type: LocalParameter
units: 006281
value: 1000.0

306656
type: LocalParameter
units: 006281
value: -1000.0

011737
type: SpeciesReference
stoichiometry: 1.0
species: 302606

302606
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Calcium

011725
type: SpeciesReference
stoichiometry: 1.0
species: 303299

303299
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Calcium

304632
type: Reaction
reactant: 026909
fast: false
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 026921
name: phosphatidylinositol 4-kinase (C16:0,C18:2)
kinetic law: 026957
product: 026945
reversible: false
product: 026933
reactant: 026897

026909
type: SpeciesReference
stoichiometry: 1.0
species: 303059

026921
type: SpeciesReference
stoichiometry: 1.0
species: 302549

309375
type: LocalParameter
units: 006281
value: 0.0

309373
type: LocalParameter
units: 006281
value: 0.0

309371
type: LocalParameter
units: 006281
value: 1000.0

309369
type: LocalParameter
units: 006281
value: 0.0

026945
type: SpeciesReference
stoichiometry: 1.0
species: 303038

026933
type: SpeciesReference
stoichiometry: 1.0
species: 302819

026897
type: SpeciesReference
stoichiometry: 1.0
species: 302589

303881
type: Reaction
reactant: 010814
fast: false
reactant: 010790
reactant: 010802
product: 010826
product: 010838
notes: GENE_ASSOCIATION: AmpD3.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
name: Adenosine monophosphate deaminase
kinetic law: 010851
reversible: false

010814
type: SpeciesReference
stoichiometry: 1.0
species: 302822

010790
type: SpeciesReference
stoichiometry: 1.0
species: 302578

010802
type: SpeciesReference
stoichiometry: 1.0
species: 302819

010826
type: SpeciesReference
stoichiometry: 1.0
species: 302846

010838
type: SpeciesReference
stoichiometry: 1.0
species: 302948

306485
type: LocalParameter
units: 006281
value: 0.0

306482
type: LocalParameter
units: 006281
value: 0.0

306479
type: LocalParameter
units: 006281
value: 1000.0

306476
type: LocalParameter
units: 006281
value: 0.0

303641
type: Reaction
kinetic law: 007625
reactant: 007613
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Sodium exchange

305525
type: LocalParameter
units: 006281
value: 0.0

305522
type: LocalParameter
units: 006281
value: 0.0

305519
type: LocalParameter
units: 006281
value: 10.0

305516
type: LocalParameter
units: 006281
value: -10.0

007613
type: SpeciesReference
stoichiometry: 1.0
species: 303416

304218
type: Reaction
reactant: 018237
notes: GENE_ASSOCIATION: SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 018297
product: 018261
reversible: false
name: Glycerophosphodiester phosphodiesterase (Glycerophosphocholine)
product: 018285
product: 018273
fast: false
reactant: 018249

018237
type: SpeciesReference
stoichiometry: 1.0
species: 302753

302753
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: sn-Glycero-3-phosphocholine

307839
type: LocalParameter
units: 006281
value: 0.0

307836
type: LocalParameter
units: 006281
value: 0.0

307833
type: LocalParameter
units: 006281
value: 1000.0

307830
type: LocalParameter
units: 006281
value: 0.0

018261
type: SpeciesReference
stoichiometry: 1.0
species: 302642

018285
type: SpeciesReference
stoichiometry: 1.0
species: 302819

018273
type: SpeciesReference
stoichiometry: 1.0
species: 302795

302795
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Glycerol 3-phosphate

018249
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304428
type: Reaction
reactant: 022489
reactant: 022501
reactant: 022477
reversible: true
name: nicotinate-nucleotide adenylyltransferase
product: 022525
notes: GENE_ASSOCIATION: Nmnat3.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
product: 022513
kinetic law: 022537

022489
type: SpeciesReference
stoichiometry: 1.0
species: 302819

022501
type: SpeciesReference
stoichiometry: 1.0
species: 302954

022477
type: SpeciesReference
stoichiometry: 1.0
species: 302589

022525
type: SpeciesReference
stoichiometry: 1.0
species: 303143

022513
type: SpeciesReference
stoichiometry: 1.0
species: 302708

302708
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Deamino-NAD+

308679
type: LocalParameter
units: 006281
value: 0.0

308676
type: LocalParameter
units: 006281
value: 0.0

308673
type: LocalParameter
units: 006281
value: 1000.0

308670
type: LocalParameter
units: 006281
value: -1000.0

304455
type: Reaction
name: 5'-nucleotidase (GMP)
product: 023100
product: 023088
reactant: 023064
reactant: 023076
reversible: false
notes: GENE_ASSOCIATION: Nt5C2.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
kinetic law: 023112

023100
type: SpeciesReference
stoichiometry: 1.0
species: 303131

023088
type: SpeciesReference
stoichiometry: 1.0
species: 302801

302801
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Guanosine

023064
type: SpeciesReference
stoichiometry: 1.0
species: 302798

023076
type: SpeciesReference
stoichiometry: 1.0
species: 302822

308787
type: LocalParameter
units: 006281
value: 0.0

308784
type: LocalParameter
units: 006281
value: 0.0

308781
type: LocalParameter
units: 006281
value: 1000.0

308778
type: LocalParameter
units: 006281
value: 0.0

304383
type: Reaction
kinetic law: 021604
product: 021592
reactant: 021580
notes: GENE_ASSOCIATION: Isyna1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: myo-Inositol-1-phosphate synthase

308499
type: LocalParameter
units: 006281
value: 0.0

308496
type: LocalParameter
units: 006281
value: 0.0

308493
type: LocalParameter
units: 006281
value: 1000.0

308490
type: LocalParameter
units: 006281
value: 0.0

021592
type: SpeciesReference
stoichiometry: 1.0
species: 302921

021580
type: SpeciesReference
stoichiometry: 1.0
species: 302756

304862
type: Reaction
product: 031830
reactant: 031806
kinetic law: 031842
product: 031818
notes: GENE_ASSOCIATION: UmpK.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reversible: true
name: UMP kinase
fast: false
reactant: 031794

031830
type: SpeciesReference
stoichiometry: 1.0
species: 303215

031806
type: SpeciesReference
stoichiometry: 1.0
species: 303227

309991
type: LocalParameter
units: 006281
value: 0.0

309989
type: LocalParameter
units: 006281
value: 0.0

309987
type: LocalParameter
units: 006281
value: 1000.0

309985
type: LocalParameter
units: 006281
value: -1000.0

031818
type: SpeciesReference
stoichiometry: 1.0
species: 302549

031794
type: SpeciesReference
stoichiometry: 1.0
species: 302589

302508
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Methylthioadenosine

303614
type: Reaction
kinetic law: 007409
reactant: 007396
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-lactate exchange

305417
type: LocalParameter
units: 006281
value: 0.0

305414
type: LocalParameter
units: 006281
value: 0.0

305411
type: LocalParameter
units: 006281
value: 1.46778073333337

305408
type: LocalParameter
units: 006281
value: 0.0

007396
type: SpeciesReference
stoichiometry: 1.0
species: 303389

303389
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: D-Lactate

303392
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Lactate

303887
type: Reaction
fast: false
name: Acireductone Dixoygenase 1 (homo sapiens)
product: 010962
reactant: 010937
product: 010974
product: 010986
notes: GENE_ASSOCIATION: Adi1 SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
reversible: false
kinetic law: 010998
reactant: 010949

010962
type: SpeciesReference
stoichiometry: 1.0
species: 302478

302478
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 2-keto-4-methylthiobutyrate

010937
type: SpeciesReference
stoichiometry: 1.0
species: 302702

302702
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

010974
type: SpeciesReference
stoichiometry: 1.0
species: 302739

302739
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Formate

010986
type: SpeciesReference
stoichiometry: 2.0
species: 302819

306509
type: LocalParameter
units: 006281
value: 0.0

306506
type: LocalParameter
units: 006281
value: 0.0

306503
type: LocalParameter
units: 006281
value: 1000.0

306500
type: LocalParameter
units: 006281
value: 0.0

010949
type: SpeciesReference
stoichiometry: 1.0
species: 302966

304602
type: Reaction
fast: false
product: 026289
name: phosphatidylinositol 4-phosphate phospholipase C (C18:2,C18:1)
product: 026301
kinetic law: 026313
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 026253
product: 026277
reactant: 026265
reversible: false

026289
type: SpeciesReference
stoichiometry: 1.0
species: 302819

026301
type: SpeciesReference
stoichiometry: 1.0
species: 302918

309295
type: LocalParameter
units: 006281
value: 0.0

309293
type: LocalParameter
units: 006281
value: 0.0

309291
type: LocalParameter
units: 006281
value: 1000.0

309289
type: LocalParameter
units: 006281
value: 0.0

026253
type: SpeciesReference
stoichiometry: 1.0
species: 302822

026277
type: SpeciesReference
stoichiometry: 1.0
species: 302693

026265
type: SpeciesReference
stoichiometry: 1.0
species: 303050

304143
type: Reaction
notes: GENE_ASSOCIATION: Gnpda1.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
product: 016563
reactant: 016539
reactant: 016527
product: 016551
reversible: false
name: glucosamine-6-phosphate deaminase
kinetic law: 016575
fast: false

016563
type: SpeciesReference
stoichiometry: 1.0
species: 302948

016539
type: SpeciesReference
stoichiometry: 1.0
species: 302822

016527
type: SpeciesReference
stoichiometry: 1.0
species: 302769

302769
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucosamine 6-phosphate

016551
type: SpeciesReference
stoichiometry: 1.0
species: 302726

307539
type: LocalParameter
units: 006281
value: 0.0

307536
type: LocalParameter
units: 006281
value: 0.0

307533
type: LocalParameter
units: 006281
value: 1000.0

307530
type: LocalParameter
units: 006281
value: 0.0

304835
type: Reaction
name: transketolase
fast: false
product: 031275
reactant: 031263
reactant: 031251
kinetic law: 031300
reversible: true
product: 031287
notes: GENE_ASSOCIATION: Tkt.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:

031275
type: SpeciesReference
stoichiometry: 1.0
species: 302751

031263
type: SpeciesReference
stoichiometry: 1.0
species: 303245

303245
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Xylulose 5-phosphate

031251
type: SpeciesReference
stoichiometry: 1.0
species: 303179

309919
type: LocalParameter
units: 006281
value: 0.0

309917
type: LocalParameter
units: 006281
value: 0.0

309915
type: LocalParameter
units: 006281
value: 1000.0

309913
type: LocalParameter
units: 006281
value: -1000.0

031287
type: SpeciesReference
stoichiometry: 1.0
species: 303191

304593
type: Reaction
product: 026061
kinetic law: 026097
reactant: 026037
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 026073
reactant: 026049
fast: false
product: 026085
name: phosphatidylinositol 4-phosphate phospholipase C (C18:1,C18:1)

026061
type: SpeciesReference
stoichiometry: 1.0
species: 302684

309271
type: LocalParameter
units: 006281
value: 0.0

309269
type: LocalParameter
units: 006281
value: 0.0

309267
type: LocalParameter
units: 006281
value: 1000.0

309265
type: LocalParameter
units: 006281
value: 0.0

026037
type: SpeciesReference
stoichiometry: 1.0
species: 302822

026073
type: SpeciesReference
stoichiometry: 1.0
species: 302819

026049
type: SpeciesReference
stoichiometry: 1.0
species: 303041

026085
type: SpeciesReference
stoichiometry: 1.0
species: 302918

304790
type: Reaction
kinetic law: 030393
product: 030381
reactant: 030369
notes: GENE_ASSOCIATION: Rpe.2 or Rpe.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase

309799
type: LocalParameter
units: 006281
value: 0.0

309797
type: LocalParameter
units: 006281
value: 0.0

309795
type: LocalParameter
units: 006281
value: 1000.0

309793
type: LocalParameter
units: 006281
value: -1000.0

030381
type: SpeciesReference
stoichiometry: 1.0
species: 303245

030369
type: SpeciesReference
stoichiometry: 1.0
species: 303188

303188
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Ribulose 5-phosphate

303752
type: Reaction
kinetic law: 008521
reactant: 008509
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 18 2 16 0(c)

305969
type: LocalParameter
units: 006281
value: 0.0

305966
type: LocalParameter
units: 006281
value: 0.0

305963
type: LocalParameter
units: 006281
value: 10.0

305960
type: LocalParameter
units: 006281
value: -10.0

008509
type: SpeciesReference
stoichiometry: 1.0
species: 303089

304116
type: Reaction
notes: GENE_ASSOCIATION: EnpP1.1 SUBSYSTEM: Riboflavin Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 016118
reversible: false
product: 016082
product: 016094
product: 016106
name: FAD diphosphatase
reactant: 016070
reactant: 016058
fast: false

307431
type: LocalParameter
units: 006281
value: 0.0

307428
type: LocalParameter
units: 006281
value: 0.0

307425
type: LocalParameter
units: 006281
value: 1000.0

307422
type: LocalParameter
units: 006281
value: 0.0

016082
type: SpeciesReference
stoichiometry: 1.0
species: 302578

016094
type: SpeciesReference
stoichiometry: 1.0
species: 302736

016106
type: SpeciesReference
stoichiometry: 2.0
species: 302819

016070
type: SpeciesReference
stoichiometry: 1.0
species: 302822

016058
type: SpeciesReference
stoichiometry: 1.0
species: 302728

302728
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Flavin adenine dinucleotide oxidized

304389
type: Reaction
kinetic law: 021701
product: 021689
reactant: 021677
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: 5-methylthioribose-1-phosphate isomerase

308523
type: LocalParameter
units: 006281
value: 0.0

308520
type: LocalParameter
units: 006281
value: 0.0

308517
type: LocalParameter
units: 006281
value: 1000.0

308514
type: LocalParameter
units: 006281
value: -1000.0

021689
type: SpeciesReference
stoichiometry: 1.0
species: 302505

302505
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate

021677
type: SpeciesReference
stoichiometry: 1.0
species: 302502

304566
type: Reaction
reactant: 025396
fast: false
kinetic law: 025444
product: 025432
name: phosphatidylinositol 4-phosphate 5-kinase (C16:0,C18:1)
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 025420
product: 025408
reversible: false
reactant: 025384

025396
type: SpeciesReference
stoichiometry: 1.0
species: 303035

309199
type: LocalParameter
units: 006281
value: 0.0

309197
type: LocalParameter
units: 006281
value: 0.0

309195
type: LocalParameter
units: 006281
value: 1000.0

309193
type: LocalParameter
units: 006281
value: 0.0

025432
type: SpeciesReference
stoichiometry: 1.0
species: 303014

303014
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C18:1)

025420
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025408
type: SpeciesReference
stoichiometry: 1.0
species: 302549

025384
type: SpeciesReference
stoichiometry: 1.0
species: 302589

303548
type: Reaction
kinetic law: 006874
reactant: 006862
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Dopamine exchange

305153
type: LocalParameter
units: 006281
value: 0.0

305150
type: LocalParameter
units: 006281
value: 0.0

305147
type: LocalParameter
units: 006281
value: 0.0

305145
type: LocalParameter
units: 006281
value: -0.0324

006862
type: SpeciesReference
stoichiometry: 1.0
species: 303323

303575
type: Reaction
kinetic law: 007093
reactant: 007081
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 5-L-Glutamyl-L-alanine exchange

305261
type: LocalParameter
units: 006281
value: 0.0

305258
type: LocalParameter
units: 006281
value: 0.0

305255
type: LocalParameter
units: 006281
value: 0.0

305252
type: LocalParameter
units: 006281
value: -0.08

007081
type: SpeciesReference
stoichiometry: 1.0
species: 303350

303350
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 5-L-Glutamyl-L-alanine

304281
type: Reaction
fast: false
product: 019648
reactant: 019588
reversible: false
reactant: 019600
kinetic law: 019685
product: 019672
notes: GENE_ASSOCIATION: Hmox2.1 or Hmox1.1 SUBSYSTEM: Heme Degradation EC Number: Confidence Level: AUTHORS:
product: 019624
product: 019660
reactant: 019576
reactant: 019612
name: Heme oxygenase 1
product: 019636

019648
type: SpeciesReference
stoichiometry: 1.0
species: 302733

019588
type: SpeciesReference
stoichiometry: 3.0
species: 302942

019600
type: SpeciesReference
stoichiometry: 3.0
species: 302966

308091
type: LocalParameter
units: 006281
value: 0.0

308088
type: LocalParameter
units: 006281
value: 0.0

308085
type: LocalParameter
units: 006281
value: 1000.0

308082
type: LocalParameter
units: 006281
value: 0.0

019672
type: SpeciesReference
stoichiometry: 3.0
species: 302939

019624
type: SpeciesReference
stoichiometry: 1.0
species: 302603

019660
type: SpeciesReference
stoichiometry: 3.0
species: 302822

019576
type: SpeciesReference
stoichiometry: 5.0
species: 302819

019612
type: SpeciesReference
stoichiometry: 1.0
species: 303125

019636
type: SpeciesReference
stoichiometry: 1.0
species: 302654

303107
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C18:1, C18:1)

303998
type: Reaction
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013490
product: 013502
product: 013478
reversible: false
kinetic law: 013514
reactant: 013454
name: choline phosphotransferase (C18:2, C18:1)
reactant: 013466
fast: false

013490
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013502
type: SpeciesReference
stoichiometry: 1.0
species: 303092

013478
type: SpeciesReference
stoichiometry: 1.0
species: 302651

306953
type: LocalParameter
units: 006281
value: 0.0

306950
type: LocalParameter
units: 006281
value: 0.0

306947
type: LocalParameter
units: 006281
value: 1000.0

306944
type: LocalParameter
units: 006281
value: 0.0

013454
type: SpeciesReference
stoichiometry: 1.0
species: 302615

013466
type: SpeciesReference
stoichiometry: 1.0
species: 302693

304001
type: Reaction
kinetic law: 013586
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013574
product: 013562
reversible: false
fast: false
reactant: 013538
reactant: 013526
name: ethanolamine phosphotransferase (C16:0,C16:0)
product: 013550

306965
type: LocalParameter
units: 006281
value: 0.0

306962
type: LocalParameter
units: 006281
value: 0.0

306959
type: LocalParameter
units: 006281
value: 1000.0

306956
type: LocalParameter
units: 006281
value: 0.0

013574
type: SpeciesReference
stoichiometry: 1.0
species: 303098

303098
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C16:0, C16:0)

013562
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013538
type: SpeciesReference
stoichiometry: 1.0
species: 302675

013526
type: SpeciesReference
stoichiometry: 1.0
species: 302639

013550
type: SpeciesReference
stoichiometry: 1.0
species: 302651

304769
type: Reaction
kinetic law: 029887
product: 029875
reactant: 029863
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: pyridoxal transport via diffusion

309743
type: LocalParameter
units: 006281
value: 0.0

309741
type: LocalParameter
units: 006281
value: 0.0

309739
type: LocalParameter
units: 006281
value: 1000.0

309737
type: LocalParameter
units: 006281
value: -1000.0

029875
type: SpeciesReference
stoichiometry: 1.0
species: 303164

029863
type: SpeciesReference
stoichiometry: 1.0
species: 303455

303455
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Pyridoxal

304254
type: Reaction
reactant: 019042
product: 019066
notes: GENE_ASSOCIATION: Ca1.1 or Ca2.1 or Ca3.1 SUBSYSTEM: Miscellaneous EC Number: Confidence Level: AUTHORS:
name: HCO3 equilibration reaction
reactant: 019030
fast: false
product: 019054
kinetic law: 019078
reversible: true

019042
type: SpeciesReference
stoichiometry: 1.0
species: 302822

019066
type: SpeciesReference
stoichiometry: 1.0
species: 302828

019030
type: SpeciesReference
stoichiometry: 1.0
species: 302657

019054
type: SpeciesReference
stoichiometry: 1.0
species: 302819

307983
type: LocalParameter
units: 006281
value: 0.0

307980
type: LocalParameter
units: 006281
value: 0.0

307977
type: LocalParameter
units: 006281
value: 1000.0

307974
type: LocalParameter
units: 006281
value: -1000.0

304796
type: Reaction
reversible: false
reactant: 030441
kinetic law: 030501
product: 030465
name: S-Adenosyl-L-methionine:catechol O-methyltransferase
notes: GENE_ASSOCIATION: Comt.2 or Comt.1 SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: AUTHORS:
product: 030489
fast: false
product: 030477
reactant: 030453

030441
type: SpeciesReference
stoichiometry: 1.0
species: 302572

309815
type: LocalParameter
units: 006281
value: 0.0

309813
type: LocalParameter
units: 006281
value: 0.0

309811
type: LocalParameter
units: 006281
value: 1000.0

309809
type: LocalParameter
units: 006281
value: 0.0

030465
type: SpeciesReference
stoichiometry: 1.0
species: 302556

030489
type: SpeciesReference
stoichiometry: 1.0
species: 302960

302960
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Normetanephrine

030477
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030453
type: SpeciesReference
stoichiometry: 1.0
species: 302963

303758
type: Reaction
kinetic law: 008569
reactant: 008557
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pe hs 16 0 16 0(c)

305993
type: LocalParameter
units: 006281
value: 0.0

305990
type: LocalParameter
units: 006281
value: 0.0

305987
type: LocalParameter
units: 006281
value: 10.0

305984
type: LocalParameter
units: 006281
value: -10.0

008557
type: SpeciesReference
stoichiometry: 1.0
species: 303098

303686
type: Reaction
kinetic law: 007989
reactant: 007976
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Pyruvate exchange

305705
type: LocalParameter
units: 006281
value: 0.0

305702
type: LocalParameter
units: 006281
value: 0.0

305699
type: LocalParameter
units: 006281
value: 3.67559886666673

305696
type: LocalParameter
units: 006281
value: 0.0

007976
type: SpeciesReference
stoichiometry: 1.0
species: 303461

303896
type: Reaction
kinetic law: 011155
name: acireductone synthase (homo sapiens)
reactant: 011119
reversible: false
notes: GENE_ASSOCIATION: Enoph1 SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
product: 011143
product: 011131
reactant: 011107
fast: false

306545
type: LocalParameter
units: 006281
value: 0.0

306542
type: LocalParameter
units: 006281
value: 0.0

306539
type: LocalParameter
units: 006281
value: 1000.0

306536
type: LocalParameter
units: 006281
value: 0.0

011119
type: SpeciesReference
stoichiometry: 1.0
species: 302822

011143
type: SpeciesReference
stoichiometry: 1.0
species: 303131

011131
type: SpeciesReference
stoichiometry: 1.0
species: 302702

011107
type: SpeciesReference
stoichiometry: 1.0
species: 302705

302705
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 2,3-diketo-5-methylthio-1-phosphopentane

304007
type: Reaction
reactant: 013682
reactant: 013670
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013718
kinetic law: 013730
reversible: false
name: ethanolamine phosphotransferase (C16:0,C18:2)
product: 013706
product: 013694
fast: false

013682
type: SpeciesReference
stoichiometry: 1.0
species: 302681

013670
type: SpeciesReference
stoichiometry: 1.0
species: 302639

013718
type: SpeciesReference
stoichiometry: 1.0
species: 303104

306989
type: LocalParameter
units: 006281
value: 0.0

306986
type: LocalParameter
units: 006281
value: 0.0

306983
type: LocalParameter
units: 006281
value: 1000.0

306980
type: LocalParameter
units: 006281
value: 0.0

013706
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013694
type: SpeciesReference
stoichiometry: 1.0
species: 302651

304401
type: Reaction
product: 021969
reactant: 021920
product: 021981
reactant: 021908
notes: GENE_ASSOCIATION: Nadsyn1.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
product: 021993
fast: false
reactant: 021932
kinetic law: 022005
reactant: 021896
product: 021944
reversible: false
product: 021957
name: NAD synthase (glutamine-hydrolysing)

021969
type: SpeciesReference
stoichiometry: 1.0
species: 302819

021920
type: SpeciesReference
stoichiometry: 1.0
species: 302780

302780
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Glutamine

021981
type: SpeciesReference
stoichiometry: 1.0
species: 302933

021908
type: SpeciesReference
stoichiometry: 1.0
species: 302708

021993
type: SpeciesReference
stoichiometry: 1.0
species: 303143

021932
type: SpeciesReference
stoichiometry: 1.0
species: 302822

308571
type: LocalParameter
units: 006281
value: 0.0

308568
type: LocalParameter
units: 006281
value: 0.0

308565
type: LocalParameter
units: 006281
value: 1000.0

308562
type: LocalParameter
units: 006281
value: 0.0

021896
type: SpeciesReference
stoichiometry: 1.0
species: 302589

021944
type: SpeciesReference
stoichiometry: 1.0
species: 302578

021957
type: SpeciesReference
stoichiometry: 1.0
species: 302783

304188
type: Reaction
kinetic law: 017533
product: 017521
reactant: 017509
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: glycerol transport via channel

307719
type: LocalParameter
units: 006281
value: 0.0

307716
type: LocalParameter
units: 006281
value: 0.0

307713
type: LocalParameter
units: 006281
value: 1000.0

307710
type: LocalParameter
units: 006281
value: -1000.0

017521
type: SpeciesReference
stoichiometry: 1.0
species: 303356

017509
type: SpeciesReference
stoichiometry: 1.0
species: 302792

302792
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Glycerol

303482
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Uridine

303905
type: Reaction
reactant: 011289
fast: false
product: 011302
product: 011314
notes: GENE_ASSOCIATION: Slco1b3.1 or Slco1b1.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: true
name: bilirubin monoglucuronide transport via bicarbonate countertransport
kinetic law: 011326
reactant: 011277

011289
type: SpeciesReference
stoichiometry: 1.0
species: 303296

303296
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Bilirubin monoglucuronide

011302
type: SpeciesReference
stoichiometry: 1.0
species: 302597

302597
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Bilirubin monoglucuronide

011314
type: SpeciesReference
stoichiometry: 1.0
species: 303371

306581
type: LocalParameter
units: 006281
value: 0.0

306578
type: LocalParameter
units: 006281
value: 0.0

306575
type: LocalParameter
units: 006281
value: 1000.0

306572
type: LocalParameter
units: 006281
value: -1000.0

011277
type: SpeciesReference
stoichiometry: 1.0
species: 302828

304611
type: Reaction
product: 026470
kinetic law: 026495
product: 026482
reactant: 026445
reversible: false
fast: false
reactant: 026457
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C18:2)

026470
type: SpeciesReference
stoichiometry: 1.0
species: 303059

309319
type: LocalParameter
units: 006281
value: 0.0

309317
type: LocalParameter
units: 006281
value: 0.0

309315
type: LocalParameter
units: 006281
value: 1000.0

309313
type: LocalParameter
units: 006281
value: 0.0

026482
type: SpeciesReference
stoichiometry: 1.0
species: 303131

026445
type: SpeciesReference
stoichiometry: 1.0
species: 302822

026457
type: SpeciesReference
stoichiometry: 1.0
species: 303038

304407
type: Reaction
kinetic law: 022078
product: 022066
reactant: 022053
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Nicotinamide acid uptake

308595
type: LocalParameter
units: 006281
value: 0.0

308592
type: LocalParameter
units: 006281
value: 0.0

308589
type: LocalParameter
units: 006281
value: 1000.0

308586
type: LocalParameter
units: 006281
value: -1000.0

022066
type: SpeciesReference
stoichiometry: 1.0
species: 302945

302945
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Nicotinamide

022053
type: SpeciesReference
stoichiometry: 1.0
species: 303422

304398
type: Reaction
product: 021871
kinetic law: 021883
product: 021846
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
name: NADP nucleosidase
product: 021859
reactant: 021834
reactant: 021822

021871
type: SpeciesReference
stoichiometry: 1.0
species: 302945

308559
type: LocalParameter
units: 006281
value: 0.0

308556
type: LocalParameter
units: 006281
value: 0.0

308553
type: LocalParameter
units: 006281
value: 1000.0

308550
type: LocalParameter
units: 006281
value: 0.0

021846
type: SpeciesReference
stoichiometry: 1.0
species: 302552

302552
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: ADPribose 2'-phosphate

021859
type: SpeciesReference
stoichiometry: 1.0
species: 302819

021834
type: SpeciesReference
stoichiometry: 1.0
species: 302939

021822
type: SpeciesReference
stoichiometry: 1.0
species: 302822

303584
type: Reaction
kinetic law: 007167
reactant: 007154
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Oxidized glutathione exchange

305297
type: LocalParameter
units: 006281
value: 0.0

305294
type: LocalParameter
units: 006281
value: 0.0

305291
type: LocalParameter
units: 006281
value: 0.04

305288
type: LocalParameter
units: 006281
value: 0.0

007154
type: SpeciesReference
stoichiometry: 1.0
species: 303359

302514
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 6-Phospho-D-gluconate

304617
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 026568
kinetic law: 026618
name: phosphatidylinositol-4-phosphate 4-phosphatase (C18:1,C18:2)
product: 026593
reactant: 026581
reversible: false
product: 026606
fast: false

026568
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309335
type: LocalParameter
units: 006281
value: 0.0

309333
type: LocalParameter
units: 006281
value: 0.0

309331
type: LocalParameter
units: 006281
value: 1000.0

309329
type: LocalParameter
units: 006281
value: 0.0

026593
type: SpeciesReference
stoichiometry: 1.0
species: 303065

303065
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol (homo sapiens, C18:1, C18:2)

026581
type: SpeciesReference
stoichiometry: 1.0
species: 303044

026606
type: SpeciesReference
stoichiometry: 1.0
species: 303131

304814
type: Reaction
product: 030864
reversible: false
product: 030876
reactant: 030852
notes: GENE_ASSOCIATION: Sms.1 SUBSYSTEM: Urea cycle/amino group metabolism EC Number: Confidence Level: AUTHORS:
product: 030888
kinetic law: 030900
name: spermine synthase
fast: false
reactant: 030840

030864
type: SpeciesReference
stoichiometry: 1.0
species: 302508

030876
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030852
type: SpeciesReference
stoichiometry: 1.0
species: 303197

303197
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Spermidine

030888
type: SpeciesReference
stoichiometry: 1.0
species: 303200

309863
type: LocalParameter
units: 006281
value: 0.0

309861
type: LocalParameter
units: 006281
value: 0.0

309859
type: LocalParameter
units: 006281
value: 1000.0

309857
type: LocalParameter
units: 006281
value: 0.0

030840
type: SpeciesReference
stoichiometry: 1.0
species: 302575

302575
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: S-Adenosylmethioninamine

304572
type: Reaction
name: phosphatidylinositol 4-phosphate 5-kinase (C18:1,C18:1)
reversible: false
kinetic law: 025589
fast: false
reactant: 025540
product: 025577
reactant: 025528
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 025553
product: 025565

309215
type: LocalParameter
units: 006281
value: 0.0

309213
type: LocalParameter
units: 006281
value: 0.0

309211
type: LocalParameter
units: 006281
value: 1000.0

309209
type: LocalParameter
units: 006281
value: 0.0

025540
type: SpeciesReference
stoichiometry: 1.0
species: 303041

025577
type: SpeciesReference
stoichiometry: 1.0
species: 303020

025528
type: SpeciesReference
stoichiometry: 1.0
species: 302589

025553
type: SpeciesReference
stoichiometry: 1.0
species: 302549

025565
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303803
type: Reaction
reactant: 009273
reversible: false
notes: GENE_ASSOCIATION: Nanp.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
kinetic law: 009309
product: 009297
reactant: 009261
product: 009285
name: N-Acetylneuraminate 9-phosphate phosphohydrolase

009273
type: SpeciesReference
stoichiometry: 1.0
species: 302822

306173
type: LocalParameter
units: 006281
value: 0.0

306170
type: LocalParameter
units: 006281
value: 0.0

306167
type: LocalParameter
units: 006281
value: 1000.0

306164
type: LocalParameter
units: 006281
value: 0.0

009297
type: SpeciesReference
stoichiometry: 1.0
species: 303131

009261
type: SpeciesReference
stoichiometry: 1.0
species: 302541

009285
type: SpeciesReference
stoichiometry: 1.0
species: 302538

303731
type: Reaction
kinetic law: 008352
reactant: 008340
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink mi145p(c)

305885
type: LocalParameter
units: 006281
value: 0.0

305882
type: LocalParameter
units: 006281
value: 0.0

305879
type: LocalParameter
units: 006281
value: 10.0

305876
type: LocalParameter
units: 006281
value: -10.0

008340
type: SpeciesReference
stoichiometry: 1.0
species: 302915

302767
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Glucosamine

304079
type: Reaction
kinetic law: 015307
product: 015295
reactant: 015283
notes: GENE_ASSOCIATION: Slc2a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: dehydroascorbate transport (uniport)

307275
type: LocalParameter
units: 006281
value: 0.0

307272
type: LocalParameter
units: 006281
value: 0.0

307269
type: LocalParameter
units: 006281
value: 1000.0

307266
type: LocalParameter
units: 006281
value: -1000.0

015295
type: SpeciesReference
stoichiometry: 1.0
species: 302699

302699
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Dehydroascorbate

015283
type: SpeciesReference
stoichiometry: 1.0
species: 303320

303320
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Dehydroascorbate

304545
type: Reaction
reversible: false
reactant: 024889
kinetic law: 024937
product: 024925
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C18:1)
fast: false
product: 024901
reactant: 024877
product: 024913
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:

024889
type: SpeciesReference
stoichiometry: 1.0
species: 303014

309143
type: LocalParameter
units: 006281
value: 0.0

309141
type: LocalParameter
units: 006281
value: 0.0

309139
type: LocalParameter
units: 006281
value: 1000.0

309137
type: LocalParameter
units: 006281
value: 0.0

024925
type: SpeciesReference
stoichiometry: 1.0
species: 302915

024901
type: SpeciesReference
stoichiometry: 1.0
species: 302678

024877
type: SpeciesReference
stoichiometry: 1.0
species: 302822

024913
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304305
type: Reaction
product: 020122
kinetic law: 020134
reversible: true
reactant: 020098
notes: GENE_ASSOCIATION: Slc16a1.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
name: L-lactate reversible transport via proton symport
reactant: 020086
fast: false
product: 020110

020122
type: SpeciesReference
stoichiometry: 1.0
species: 302861

308187
type: LocalParameter
units: 006281
value: 0.0

308184
type: LocalParameter
units: 006281
value: 0.0

308181
type: LocalParameter
units: 006281
value: 1000.0

308178
type: LocalParameter
units: 006281
value: -1000.0

020098
type: SpeciesReference
stoichiometry: 1.0
species: 303392

020086
type: SpeciesReference
stoichiometry: 1.0
species: 303362

020110
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303527
type: Reaction
kinetic law: 006703
reactant: 006691
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: cAMP exchange

305072
type: LocalParameter
units: 006281
value: 0.0

305069
type: LocalParameter
units: 006281
value: 0.0

305066
type: LocalParameter
units: 006281
value: 0.024

305063
type: LocalParameter
units: 006281
value: 0.0

006691
type: SpeciesReference
stoichiometry: 1.0
species: 303302

304260
type: Reaction
kinetic law: 019177
product: 019165
reactant: 019153
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Homocysteine transport (extracellular)

308007
type: LocalParameter
units: 006281
value: 0.0

308004
type: LocalParameter
units: 006281
value: 0.0

308001
type: LocalParameter
units: 006281
value: 1000.0

307998
type: LocalParameter
units: 006281
value: -1000.0

019165
type: SpeciesReference
stoichiometry: 1.0
species: 302831

302831
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Homocysteine

019153
type: SpeciesReference
stoichiometry: 1.0
species: 303374

303374
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Homocysteine

303941
type: Reaction
reactant: 012088
product: 012124
product: 012100
name: phosphatidylinositol synthase (Homo sapiens, C16:0, C18:1)
product: 012112
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
kinetic law: 012136
reversible: true
reactant: 012076

012088
type: SpeciesReference
stoichiometry: 1.0
species: 302849

012124
type: SpeciesReference
stoichiometry: 1.0
species: 303056

012100
type: SpeciesReference
stoichiometry: 1.0
species: 302651

012112
type: SpeciesReference
stoichiometry: 1.0
species: 302819

306725
type: LocalParameter
units: 006281
value: 0.0

306722
type: LocalParameter
units: 006281
value: 0.0

306719
type: LocalParameter
units: 006281
value: 1000.0

306716
type: LocalParameter
units: 006281
value: -1000.0

012076
type: SpeciesReference
stoichiometry: 1.0
species: 302621

302621
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C16:0, C18:1)

304748
type: Reaction
kinetic law: 029499
reversible: false
name: pyridoxamine kinase
reactant: 029439
fast: false
product: 029475
product: 029463
reactant: 029451
notes: GENE_ASSOCIATION: PdxK.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
product: 029487

309687
type: LocalParameter
units: 006281
value: 0.0

309685
type: LocalParameter
units: 006281
value: 0.0

309683
type: LocalParameter
units: 006281
value: 1000.0

309681
type: LocalParameter
units: 006281
value: 0.0

029439
type: SpeciesReference
stoichiometry: 1.0
species: 302589

029475
type: SpeciesReference
stoichiometry: 1.0
species: 302819

029463
type: SpeciesReference
stoichiometry: 1.0
species: 302549

029451
type: SpeciesReference
stoichiometry: 1.0
species: 303161

303161
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxamine

029487
type: SpeciesReference
stoichiometry: 1.0
species: 303158

303158
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxamine 5'-phosphate

304233
type: Reaction
kinetic law: 018691
reversible: false
name: glutathione synthetase
product: 018654
product: 018667
fast: false
reactant: 018628
notes: GENE_ASSOCIATION: Gss.1 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 018615
product: 018679
product: 018641
reactant: 018601

307899
type: LocalParameter
units: 006281
value: 0.0

307896
type: LocalParameter
units: 006281
value: 0.0

307893
type: LocalParameter
units: 006281
value: 1000.0

307890
type: LocalParameter
units: 006281
value: 0.0

018654
type: SpeciesReference
stoichiometry: 1.0
species: 302807

018667
type: SpeciesReference
stoichiometry: 1.0
species: 302819

018628
type: SpeciesReference
stoichiometry: 1.0
species: 302789

302789
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Glycine

018615
type: SpeciesReference
stoichiometry: 1.0
species: 302786

302786
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: gamma-L-Glutamyl-L-cysteine

018679
type: SpeciesReference
stoichiometry: 1.0
species: 303131

018641
type: SpeciesReference
stoichiometry: 1.0
species: 302549

018601
type: SpeciesReference
stoichiometry: 1.0
species: 302589

303335
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Fumarate

303737
type: Reaction
kinetic law: 008401
reactant: 008389
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 16 0 16 0(c)

305909
type: LocalParameter
units: 006281
value: 0.0

305906
type: LocalParameter
units: 006281
value: 0.0

305903
type: LocalParameter
units: 006281
value: 10.0

305900
type: LocalParameter
units: 006281
value: -10.0

008389
type: SpeciesReference
stoichiometry: 1.0
species: 303074

303914
type: Reaction
reactant: 011497
notes: GENE_ASSOCIATION: Cpt1a.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
fast: false
product: 011509
reactant: 011485
product: 011521
reversible: false
kinetic law: 011533
name: carnitine O-palmitoyltransferase

011497
type: SpeciesReference
stoichiometry: 1.0
species: 303134

011509
type: SpeciesReference
stoichiometry: 1.0
species: 302660

011485
type: SpeciesReference
stoichiometry: 1.0
species: 302666

011521
type: SpeciesReference
stoichiometry: 1.0
species: 303137

306617
type: LocalParameter
units: 006281
value: 0.0

306614
type: LocalParameter
units: 006281
value: 0.0

306611
type: LocalParameter
units: 006281
value: 1000.0

306608
type: LocalParameter
units: 006281
value: 0.0

304416
type: Reaction
kinetic law: 022260
fast: false
name: nucleoside-diphosphate kinase (ATP:CDP)
product: 022236
reactant: 022224
notes: GENE_ASSOCIATION: NME7.2 or NME7.1 or NME3.1 or NME12.2 or NME6.1 or NME12.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 022211
reversible: true
product: 022248

308631
type: LocalParameter
units: 006281
value: 0.0

308628
type: LocalParameter
units: 006281
value: 0.0

308625
type: LocalParameter
units: 006281
value: 1000.0

308622
type: LocalParameter
units: 006281
value: -1000.0

022236
type: SpeciesReference
stoichiometry: 1.0
species: 302549

022224
type: SpeciesReference
stoichiometry: 1.0
species: 302612

022211
type: SpeciesReference
stoichiometry: 1.0
species: 302589

022248
type: SpeciesReference
stoichiometry: 1.0
species: 302669

304194
type: Reaction
name: hydroxyacylglutathione hydrolase
product: 017654
reactant: 017618
reactant: 017630
reversible: false
product: 017642
fast: false
kinetic law: 017678
product: 017666
notes: GENE_ASSOCIATION: Hagh.1 SUBSYSTEM: Pyruvate Metabolism EC Number: Confidence Level: AUTHORS:

017654
type: SpeciesReference
stoichiometry: 1.0
species: 302819

017618
type: SpeciesReference
stoichiometry: 1.0
species: 302822

017630
type: SpeciesReference
stoichiometry: 1.0
species: 302870

302870
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: (R)-S-Lactoylglutathione

017642
type: SpeciesReference
stoichiometry: 1.0
species: 302807

307743
type: LocalParameter
units: 006281
value: 0.0

307740
type: LocalParameter
units: 006281
value: 0.0

307737
type: LocalParameter
units: 006281
value: 1000.0

307734
type: LocalParameter
units: 006281
value: 0.0

017666
type: SpeciesReference
stoichiometry: 1.0
species: 302858

302858
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Lactate

304443
type: Reaction
name: 5'-nucleotidase (IMP)
fast: false
kinetic law: 022864
reversible: false
reactant: 022825
reactant: 022813
product: 022838
product: 022851
notes: GENE_ASSOCIATION: Nt5C2.1 SUBSYSTEM: Purine Catabolism EC Number: Confidence Level: AUTHORS:

308739
type: LocalParameter
units: 006281
value: 0.0

308736
type: LocalParameter
units: 006281
value: 0.0

308733
type: LocalParameter
units: 006281
value: 1000.0

308730
type: LocalParameter
units: 006281
value: 0.0

022825
type: SpeciesReference
stoichiometry: 1.0
species: 302846

022813
type: SpeciesReference
stoichiometry: 1.0
species: 302822

022838
type: SpeciesReference
stoichiometry: 1.0
species: 302852

302852
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Inosine

022851
type: SpeciesReference
stoichiometry: 1.0
species: 303131

304371
type: Reaction
reversible: false
reactant: 021328
reactant: 021340
fast: false
kinetic law: 021376
notes: GENE_ASSOCIATION: Inpp5d.1 or Synj1.1 or Synj1.2 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 021352
product: 021364
name: inositol-1,3,4,5-trisphosphate 5-phosphatase

021328
type: SpeciesReference
stoichiometry: 1.0
species: 302822

021340
type: SpeciesReference
stoichiometry: 1.0
species: 302909

308451
type: LocalParameter
units: 006281
value: 0.0

308448
type: LocalParameter
units: 006281
value: 0.0

308445
type: LocalParameter
units: 006281
value: 1000.0

308442
type: LocalParameter
units: 006281
value: 0.0

021352
type: SpeciesReference
stoichiometry: 1.0
species: 302912

021364
type: SpeciesReference
stoichiometry: 1.0
species: 303131

302765
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Galactitol

303602
type: Reaction
kinetic law: 007312
reactant: 007299
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Hexadecanoate (n-C16:0) exchange

305369
type: LocalParameter
units: 006281
value: 0.0

305366
type: LocalParameter
units: 006281
value: 0.0

305363
type: LocalParameter
units: 006281
value: 0.0

305360
type: LocalParameter
units: 006281
value: -0.012

007299
type: SpeciesReference
stoichiometry: 1.0
species: 303377

304850
type: Reaction
kinetic law: 031565
product: 031553
reactant: 031541
notes: GENE_ASSOCIATION: Gale.2 or Gale.1 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: UDPglucose 4-epimerase

309959
type: LocalParameter
units: 006281
value: 0.0

309957
type: LocalParameter
units: 006281
value: 0.0

309955
type: LocalParameter
units: 006281
value: 1000.0

309953
type: LocalParameter
units: 006281
value: -1000.0

031553
type: SpeciesReference
stoichiometry: 1.0
species: 303221

031541
type: SpeciesReference
stoichiometry: 1.0
species: 303218

303875
type: Reaction
notes: GENE_ASSOCIATION: Aldh1a2.2 or Aldh3a1.1 or Aldh9a1.1 or Aldh1a1.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
reversible: false
product: 010694
kinetic law: 010706
reactant: 010645
reactant: 010657
reactant: 010633
product: 010669
fast: false
product: 010682
name: aldehyde dehydrogenase (acetaldehyde, NAD)

010694
type: SpeciesReference
stoichiometry: 1.0
species: 302936

306461
type: LocalParameter
units: 006281
value: 0.0

306458
type: LocalParameter
units: 006281
value: 0.0

306455
type: LocalParameter
units: 006281
value: 1000.0

306452
type: LocalParameter
units: 006281
value: 0.0

010645
type: SpeciesReference
stoichiometry: 1.0
species: 302822

010657
type: SpeciesReference
stoichiometry: 1.0
species: 302933

010633
type: SpeciesReference
stoichiometry: 1.0
species: 302523

010669
type: SpeciesReference
stoichiometry: 1.0
species: 302520

010682
type: SpeciesReference
stoichiometry: 2.0
species: 302819

302581
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: P1,P4-Bis(5'-adenosyl) tetraphosphate

304239
type: Reaction
notes: GENE_ASSOCIATION: HprT1.1 SUBSYSTEM: Salvage Pathway EC Number: Confidence Level: AUTHORS:
kinetic law: 018800
product: 018787
name: guanine phosphoribosyltransferase
reversible: false
product: 018775
reactant: 018763
reactant: 018751
fast: false

307923
type: LocalParameter
units: 006281
value: 0.0

307920
type: LocalParameter
units: 006281
value: 0.0

307917
type: LocalParameter
units: 006281
value: 1000.0

307914
type: LocalParameter
units: 006281
value: 0.0

018787
type: SpeciesReference
stoichiometry: 1.0
species: 303143

018775
type: SpeciesReference
stoichiometry: 1.0
species: 302798

018763
type: SpeciesReference
stoichiometry: 1.0
species: 303152

018751
type: SpeciesReference
stoichiometry: 1.0
species: 302813

303353
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Glycine

302493
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3-Phospho-D-glycerate

304131
type: Reaction
reactant: 016347
notes: GENE_ASSOCIATION: FadS.1 or FadS.2 SUBSYSTEM: Riboflavin Metabolism EC Number: Confidence Level: AUTHORS:
name: FMN adenylyltransferase
reactant: 016359
product: 016383
fast: false
reversible: false
kinetic law: 016395
reactant: 016335
product: 016371

016347
type: SpeciesReference
stoichiometry: 1.0
species: 302736

016359
type: SpeciesReference
stoichiometry: 1.0
species: 302819

016383
type: SpeciesReference
stoichiometry: 1.0
species: 303143

307491
type: LocalParameter
units: 006281
value: 0.0

307488
type: LocalParameter
units: 006281
value: 0.0

307485
type: LocalParameter
units: 006281
value: 1000.0

307482
type: LocalParameter
units: 006281
value: 0.0

016335
type: SpeciesReference
stoichiometry: 1.0
species: 302589

016371
type: SpeciesReference
stoichiometry: 1.0
species: 302728

304823
type: Reaction
fast: false
product: 031080
reversible: false
product: 031056
notes: GENE_ASSOCIATION: SUBSYSTEM: Thiamine Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 031044
kinetic law: 031093
reactant: 031032
name: thiamin pyrophosphatase
product: 031068

031080
type: SpeciesReference
stoichiometry: 1.0
species: 303206

031056
type: SpeciesReference
stoichiometry: 1.0
species: 302819

031044
type: SpeciesReference
stoichiometry: 1.0
species: 303209

309887
type: LocalParameter
units: 006281
value: 0.0

309885
type: LocalParameter
units: 006281
value: 0.0

309883
type: LocalParameter
units: 006281
value: 1000.0

309881
type: LocalParameter
units: 006281
value: 0.0

031032
type: SpeciesReference
stoichiometry: 1.0
species: 302822

031068
type: SpeciesReference
stoichiometry: 1.0
species: 303131

303848
type: Reaction
product: 010114
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
kinetic law: 010138
product: 010126
reactant: 010102
reactant: 010090
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C16:0)
reversible: false
fast: false

010114
type: SpeciesReference
stoichiometry: 1.0
species: 302660

306353
type: LocalParameter
units: 006281
value: 0.0

306350
type: LocalParameter
units: 006281
value: 0.0

306347
type: LocalParameter
units: 006281
value: 1000.0

306344
type: LocalParameter
units: 006281
value: 0.0

010126
type: SpeciesReference
stoichiometry: 1.0
species: 302990

302990
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C16:0, C16:0)

010102
type: SpeciesReference
stoichiometry: 1.0
species: 303134

010090
type: SpeciesReference
stoichiometry: 1.0
species: 302564

304581
type: Reaction
fast: false
kinetic law: 025806
product: 025782
product: 025794
product: 025770
reactant: 025746
reversible: false
reactant: 025758
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-phosphate 5-kinase (C18:2,C18:1)

309239
type: LocalParameter
units: 006281
value: 0.0

309237
type: LocalParameter
units: 006281
value: 0.0

309235
type: LocalParameter
units: 006281
value: 1000.0

309233
type: LocalParameter
units: 006281
value: 0.0

025782
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025794
type: SpeciesReference
stoichiometry: 1.0
species: 303029

303029
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:2, C18:1)

025770
type: SpeciesReference
stoichiometry: 1.0
species: 302549

025746
type: SpeciesReference
stoichiometry: 1.0
species: 302589

025758
type: SpeciesReference
stoichiometry: 1.0
species: 303050

304104
type: Reaction
kinetic law: 015790
fast: false
reactant: 015742
reversible: false
reactant: 015754
name: ethanolamine phosphate phosphatase
notes: GENE_ASSOCIATION: Phospho1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 015766
product: 015778

307383
type: LocalParameter
units: 006281
value: 0.0

307380
type: LocalParameter
units: 006281
value: 0.0

307377
type: LocalParameter
units: 006281
value: 1000.0

307374
type: LocalParameter
units: 006281
value: 0.0

015742
type: SpeciesReference
stoichiometry: 1.0
species: 302720

015754
type: SpeciesReference
stoichiometry: 1.0
species: 302822

015766
type: SpeciesReference
stoichiometry: 1.0
species: 302717

015778
type: SpeciesReference
stoichiometry: 1.0
species: 303131

304377
type: Reaction
reversible: false
fast: false
notes: GENE_ASSOCIATION: Inpp5d.1 or Synj1.1 or Synj1.2 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 021484
name: inositol-1,4,5-trisphosphate 5-phosphatase
product: 021496
kinetic law: 021508
reactant: 021460
reactant: 021472

021484
type: SpeciesReference
stoichiometry: 1.0
species: 302918

021496
type: SpeciesReference
stoichiometry: 1.0
species: 303131

308475
type: LocalParameter
units: 006281
value: 0.0

308472
type: LocalParameter
units: 006281
value: 0.0

308469
type: LocalParameter
units: 006281
value: 1000.0

308466
type: LocalParameter
units: 006281
value: 0.0

021460
type: SpeciesReference
stoichiometry: 1.0
species: 302822

021472
type: SpeciesReference
stoichiometry: 1.0
species: 302915

303536
type: Reaction
kinetic law: 006776
reactant: 006763
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Carbon monoxide exchange

305108
type: LocalParameter
units: 006281
value: 0.0

305105
type: LocalParameter
units: 006281
value: 0.0

305102
type: LocalParameter
units: 006281
value: 0.0025

305099
type: LocalParameter
units: 006281
value: 0.0

006763
type: SpeciesReference
stoichiometry: 1.0
species: 303311

303563
type: Reaction
kinetic law: 006995
reactant: 006983
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: D-Galactose exchange

305213
type: LocalParameter
units: 006281
value: 0.0

305210
type: LocalParameter
units: 006281
value: 0.0

305207
type: LocalParameter
units: 006281
value: 0.0

305204
type: LocalParameter
units: 006281
value: -0.3169

006983
type: SpeciesReference
stoichiometry: 1.0
species: 303338

303773
type: Reaction
kinetic law: 008692
reactant: 008680
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: sink pe hs 18 2 16 0(c)

306053
type: LocalParameter
units: 006281
value: 0.0

306050
type: LocalParameter
units: 006281
value: 0.0

306047
type: LocalParameter
units: 006281
value: 1000.0

306044
type: LocalParameter
units: 006281
value: 0.0

008680
type: SpeciesReference
stoichiometry: 1.0
species: 303113

303113
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylethanolamine (homo sapiens, C18:2, C16:0)

304587
type: Reaction
name: phosphatidylinositol 4-phosphate phospholipase C (C16:0,C18:1)
product: 025928
product: 025916
reactant: 025892
product: 025940
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reactant: 025904
kinetic law: 025952
reversible: false

025928
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025916
type: SpeciesReference
stoichiometry: 1.0
species: 302678

025892
type: SpeciesReference
stoichiometry: 1.0
species: 302822

025940
type: SpeciesReference
stoichiometry: 1.0
species: 302918

025904
type: SpeciesReference
stoichiometry: 1.0
species: 303035

309255
type: LocalParameter
units: 006281
value: 0.0

309253
type: LocalParameter
units: 006281
value: 0.0

309251
type: LocalParameter
units: 006281
value: 1000.0

309249
type: LocalParameter
units: 006281
value: 0.0

304757
type: Reaction
notes: GENE_ASSOCIATION: PdxK.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
product: 029644
reactant: 029620
kinetic law: 029680
product: 029668
name: pyridoxal kinase
product: 029656
fast: false
reactant: 029632
reversible: false

029644
type: SpeciesReference
stoichiometry: 1.0
species: 302549

029620
type: SpeciesReference
stoichiometry: 1.0
species: 302589

309711
type: LocalParameter
units: 006281
value: 0.0

309709
type: LocalParameter
units: 006281
value: 0.0

309707
type: LocalParameter
units: 006281
value: 1000.0

309705
type: LocalParameter
units: 006281
value: 0.0

029668
type: SpeciesReference
stoichiometry: 1.0
species: 303167

029656
type: SpeciesReference
stoichiometry: 1.0
species: 302819

029632
type: SpeciesReference
stoichiometry: 1.0
species: 303164

304784
type: Reaction
reactant: 030201
product: 030249
reversible: false
product: 030261
notes: GENE_ASSOCIATION: Abcg2 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 030225
product: 030237
kinetic law: 030285
name: riboflavin transport out (ATP dependent)
product: 030273
reactant: 030213
fast: false

030201
type: SpeciesReference
stoichiometry: 1.0
species: 302589

030249
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030261
type: SpeciesReference
stoichiometry: 1.0
species: 303131

030225
type: SpeciesReference
stoichiometry: 1.0
species: 303182

030237
type: SpeciesReference
stoichiometry: 1.0
species: 302549

309783
type: LocalParameter
units: 006281
value: 0.0

309781
type: LocalParameter
units: 006281
value: 0.0

309779
type: LocalParameter
units: 006281
value: 1000.0

309777
type: LocalParameter
units: 006281
value: 0.0

030273
type: SpeciesReference
stoichiometry: 1.0
species: 303464

303464
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Riboflavin

030213
type: SpeciesReference
stoichiometry: 1.0
species: 302822

303746
type: Reaction
kinetic law: 008473
reactant: 008461
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 18 1 18 1(c)

305945
type: LocalParameter
units: 006281
value: 0.0

305942
type: LocalParameter
units: 006281
value: 0.0

305939
type: LocalParameter
units: 006281
value: 10.0

305936
type: LocalParameter
units: 006281
value: -10.0

008461
type: SpeciesReference
stoichiometry: 1.0
species: 303083

303083
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C18:1, C18:1)

304022
type: Reaction
product: 014073
notes: GENE_ASSOCIATION: Abcc4.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 014122
product: 014109
reversible: false
product: 014085
reactant: 014049
reactant: 014036
reactant: 014061
name: cGMP transport (ATP-dependent)
product: 014097
fast: false

014073
type: SpeciesReference
stoichiometry: 1.0
species: 302549

307047
type: LocalParameter
units: 006281
value: 0.0

307046
type: LocalParameter
units: 006281
value: 0.0

307043
type: LocalParameter
units: 006281
value: 1000.0

307040
type: LocalParameter
units: 006281
value: 0.0

014109
type: SpeciesReference
stoichiometry: 1.0
species: 303257

303257
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 3',5'-Cyclic GMP

014085
type: SpeciesReference
stoichiometry: 1.0
species: 302819

014049
type: SpeciesReference
stoichiometry: 1.0
species: 302589

014036
type: SpeciesReference
stoichiometry: 1.0
species: 302484

302484
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3',5'-Cyclic GMP

014061
type: SpeciesReference
stoichiometry: 1.0
species: 302822

014097
type: SpeciesReference
stoichiometry: 1.0
species: 303131

303497
type: Reaction
kinetic law: 006461
reactant: 006449
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Acetaldehyde exchange

304952
type: LocalParameter
units: 006281
value: 0.0

304949
type: LocalParameter
units: 006281
value: 0.0

304946
type: LocalParameter
units: 006281
value: 10.0

304943
type: LocalParameter
units: 006281
value: -10.0

006449
type: SpeciesReference
stoichiometry: 1.0
species: 303272

303920
type: Reaction
name: carnitine octadecenoyl transferase
reversible: false
product: 011629
reactant: 011605
reactant: 011617
product: 011641
kinetic law: 011653
notes: GENE_ASSOCIATION: Cpt1a.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
fast: false

011629
type: SpeciesReference
stoichiometry: 1.0
species: 302660

011605
type: SpeciesReference
stoichiometry: 1.0
species: 302666

011617
type: SpeciesReference
stoichiometry: 1.0
species: 302975

011641
type: SpeciesReference
stoichiometry: 1.0
species: 302978

306641
type: LocalParameter
units: 006281
value: 0.0

306638
type: LocalParameter
units: 006281
value: 0.0

306635
type: LocalParameter
units: 006281
value: 1000.0

306632
type: LocalParameter
units: 006281
value: 0.0

303884
type: Reaction
fast: false
notes: GENE_ASSOCIATION: NudT2.2 or NudT2.1 or NudT2.3 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 010863
product: 010887
reversible: false
product: 010913
product: 010900
name: Ap4A hydrolase, asymmetrically
reactant: 010875
kinetic law: 010925

010863
type: SpeciesReference
stoichiometry: 1.0
species: 302581

010887
type: SpeciesReference
stoichiometry: 1.0
species: 302578

010913
type: SpeciesReference
stoichiometry: 2.0
species: 302819

010900
type: SpeciesReference
stoichiometry: 1.0
species: 302589

010875
type: SpeciesReference
stoichiometry: 1.0
species: 302822

306497
type: LocalParameter
units: 006281
value: 0.0

306494
type: LocalParameter
units: 006281
value: 0.0

306491
type: LocalParameter
units: 006281
value: 1000.0

306488
type: LocalParameter
units: 006281
value: 0.0

304248
type: Reaction
kinetic law: 018982
product: 018970
reactant: 018958
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: hydrogen peroxide transport via diffusion

307959
type: LocalParameter
units: 006281
value: 0.0

307956
type: LocalParameter
units: 006281
value: 0.0

307953
type: LocalParameter
units: 006281
value: 1000.0

307950
type: LocalParameter
units: 006281
value: -1000.0

018970
type: SpeciesReference
stoichiometry: 1.0
species: 302825

302825
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Hydrogen peroxide

018958
type: SpeciesReference
stoichiometry: 1.0
species: 303368

303077
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylcholine (homo sapiens, C16:0, C18:1)

304422
type: Reaction
name: NICRNS
product: 022368
notes: GENE_ASSOCIATION: SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 022344
product: 022356
kinetic law: 022393
reactant: 022332
reversible: false
fast: false
product: 022381

022368
type: SpeciesReference
stoichiometry: 1.0
species: 302819

022344
type: SpeciesReference
stoichiometry: 1.0
species: 302951

022356
type: SpeciesReference
stoichiometry: 1.0
species: 302549

308655
type: LocalParameter
units: 006281
value: 0.0

308652
type: LocalParameter
units: 006281
value: 0.0

308649
type: LocalParameter
units: 006281
value: 1000.0

308646
type: LocalParameter
units: 006281
value: 0.0

022332
type: SpeciesReference
stoichiometry: 1.0
species: 302589

022381
type: SpeciesReference
stoichiometry: 1.0
species: 302954

304386
type: Reaction
reactant: 021616
fast: false
notes: GENE_ASSOCIATION: Mtap.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: AUTHORS:
name: 5'-methylthioadenosine phosphorylase
product: 021653
reversible: false
reactant: 021629
product: 021641
kinetic law: 021665

021616
type: SpeciesReference
stoichiometry: 1.0
species: 302508

021653
type: SpeciesReference
stoichiometry: 1.0
species: 302544

021629
type: SpeciesReference
stoichiometry: 1.0
species: 303131

021641
type: SpeciesReference
stoichiometry: 1.0
species: 302502

308511
type: LocalParameter
units: 006281
value: 0.0

308508
type: LocalParameter
units: 006281
value: 0.0

308505
type: LocalParameter
units: 006281
value: 1000.0

308502
type: LocalParameter
units: 006281
value: 0.0

302885
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidylcholine (homo sapiens, C18:1)

303572
type: Reaction
kinetic law: 007069
reactant: 007056
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-Glutamine exchange

305249
type: LocalParameter
units: 006281
value: 0.0

305246
type: LocalParameter
units: 006281
value: 0.0

305243
type: LocalParameter
units: 006281
value: 10.0

305240
type: LocalParameter
units: 006281
value: -10.0

007056
type: SpeciesReference
stoichiometry: 1.0
species: 303347

304110
type: Reaction
reversible: true
reactant: 015912
fast: false
notes: GENE_ASSOCIATION: Acsl1.1 SUBSYSTEM: Fatty acid activation EC Number: Confidence Level: AUTHORS:
name: fatty-acid--CoA ligase (octadecenoate)
product: 015937
kinetic law: 015961
reactant: 015888
product: 015949
product: 015925
reactant: 015900

015912
type: SpeciesReference
stoichiometry: 1.0
species: 302972

015937
type: SpeciesReference
stoichiometry: 1.0
species: 302975

307407
type: LocalParameter
units: 006281
value: 0.0

307404
type: LocalParameter
units: 006281
value: 0.0

307401
type: LocalParameter
units: 006281
value: 1000.0

307398
type: LocalParameter
units: 006281
value: -1000.0

015888
type: SpeciesReference
stoichiometry: 1.0
species: 302589

015949
type: SpeciesReference
stoichiometry: 1.0
species: 303143

015925
type: SpeciesReference
stoichiometry: 1.0
species: 302578

015900
type: SpeciesReference
stoichiometry: 1.0
species: 302660

304605
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 026337
kinetic law: 026373
name: phosphatidylinositol-4-phosphate 4-phosphatase (C16:0,C16:0)
reversible: false
reactant: 026325
product: 026361
fast: false
product: 026349

026337
type: SpeciesReference
stoichiometry: 1.0
species: 303032

309303
type: LocalParameter
units: 006281
value: 0.0

309301
type: LocalParameter
units: 006281
value: 0.0

309299
type: LocalParameter
units: 006281
value: 1000.0

309297
type: LocalParameter
units: 006281
value: 0.0

026325
type: SpeciesReference
stoichiometry: 1.0
species: 302822

026361
type: SpeciesReference
stoichiometry: 1.0
species: 303131

026349
type: SpeciesReference
stoichiometry: 1.0
species: 303053

304802
type: Reaction
product: 030610
name: D-sorbitol dehydrogenase (D-fructose producing)
product: 030622
reactant: 030598
fast: false
reversible: false
notes: GENE_ASSOCIATION: Sord.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 030646
product: 030634
reactant: 030585

030610
type: SpeciesReference
stoichiometry: 1.0
species: 302742

030622
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030598
type: SpeciesReference
stoichiometry: 1.0
species: 303194

309831
type: LocalParameter
units: 006281
value: 0.0

309829
type: LocalParameter
units: 006281
value: 0.0

309827
type: LocalParameter
units: 006281
value: 1000.0

309825
type: LocalParameter
units: 006281
value: 0.0

030634
type: SpeciesReference
stoichiometry: 1.0
species: 302936

030585
type: SpeciesReference
stoichiometry: 1.0
species: 302933

304094
type: Reaction
kinetic law: 015572
product: 015548
reactant: 015523
notes: GENE_ASSOCIATION: Bpgm.2 or Bpgm.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Diphosphoglycerate phosphatase
product: 015560
reactant: 015535

307335
type: LocalParameter
units: 006281
value: 0.0

307332
type: LocalParameter
units: 006281
value: 0.0

307329
type: LocalParameter
units: 006281
value: 1000.0

307326
type: LocalParameter
units: 006281
value: 0.0

015548
type: SpeciesReference
stoichiometry: 1.0
species: 302493

015523
type: SpeciesReference
stoichiometry: 1.0
species: 302475

302475
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 2,3-Disphospho-D-glycerate

015560
type: SpeciesReference
stoichiometry: 1.0
species: 303131

015535
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304560
type: Reaction
product: 025287
product: 025263
reversible: false
fast: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:2, C18:1)
kinetic law: 025299
product: 025275
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 025239
reactant: 025251

025287
type: SpeciesReference
stoichiometry: 1.0
species: 302915

025263
type: SpeciesReference
stoichiometry: 1.0
species: 302693

309183
type: LocalParameter
units: 006281
value: 0.0

309181
type: LocalParameter
units: 006281
value: 0.0

309179
type: LocalParameter
units: 006281
value: 1000.0

309177
type: LocalParameter
units: 006281
value: 0.0

025275
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025239
type: SpeciesReference
stoichiometry: 1.0
species: 302822

025251
type: SpeciesReference
stoichiometry: 1.0
species: 303029

304793
type: Reaction
kinetic law: 030429
product: 030417
reactant: 030405
notes: GENE_ASSOCIATION: Rpia.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: ribose-5-phosphate isomerase

309807
type: LocalParameter
units: 006281
value: 0.0

309805
type: LocalParameter
units: 006281
value: 0.0

309803
type: LocalParameter
units: 006281
value: 1000.0

309801
type: LocalParameter
units: 006281
value: -1000.0

030417
type: SpeciesReference
stoichiometry: 1.0
species: 303188

030405
type: SpeciesReference
stoichiometry: 1.0
species: 303179

304356
type: Reaction
reversible: false
reactant: 021004
name: malic enzyme (NADP)
reactant: 020992
product: 021028
product: 021040
notes: GENE_ASSOCIATION: Me1.1 SUBSYSTEM: Pyruvate Metabolism EC Number: Confidence Level: AUTHORS:
product: 021016
fast: false
kinetic law: 021052

021004
type: SpeciesReference
stoichiometry: 1.0
species: 302939

020992
type: SpeciesReference
stoichiometry: 1.0
species: 302891

302891
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Malate

021028
type: SpeciesReference
stoichiometry: 1.0
species: 302942

021040
type: SpeciesReference
stoichiometry: 1.0
species: 303173

021016
type: SpeciesReference
stoichiometry: 1.0
species: 302657

308391
type: LocalParameter
units: 006281
value: 0.0

308388
type: LocalParameter
units: 006281
value: 0.0

308385
type: LocalParameter
units: 006281
value: 1000.0

308382
type: LocalParameter
units: 006281
value: 0.0

304067
type: Reaction
reactant: 015004
name: Diacylglycerol phosphate kinase (homo sapiens, C18:1,C18:2)
product: 015052
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 015064
reactant: 015016
fast: false
reversible: true
product: 015028
product: 015040

015004
type: SpeciesReference
stoichiometry: 1.0
species: 302589

015052
type: SpeciesReference
stoichiometry: 1.0
species: 303002

307227
type: LocalParameter
units: 006281
value: 0.0

307224
type: LocalParameter
units: 006281
value: 0.0

307221
type: LocalParameter
units: 006281
value: 1000.0

307218
type: LocalParameter
units: 006281
value: -1000.0

015016
type: SpeciesReference
stoichiometry: 1.0
species: 302687

015028
type: SpeciesReference
stoichiometry: 1.0
species: 302549

015040
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304533
type: Reaction
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 024660
fast: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:1, C18:2)
product: 024648
reactant: 024636
reactant: 024624
kinetic law: 024672

024660
type: SpeciesReference
stoichiometry: 1.0
species: 303131

024648
type: SpeciesReference
stoichiometry: 1.0
species: 303044

024636
type: SpeciesReference
stoichiometry: 1.0
species: 303023

303023
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C18:1, C18:2)

024624
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309098
type: LocalParameter
units: 006281
value: 0.0

309096
type: LocalParameter
units: 006281
value: 0.0

309093
type: LocalParameter
units: 006281
value: 1000.0

309090
type: LocalParameter
units: 006281
value: 0.0

303515
type: Reaction
kinetic law: 006607
reactant: 006594
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Arginine exchange

305024
type: LocalParameter
units: 006281
value: 0.0

305021
type: LocalParameter
units: 006281
value: 0.0

305018
type: LocalParameter
units: 006281
value: 0.0

305015
type: LocalParameter
units: 006281
value: -0.1152

006594
type: SpeciesReference
stoichiometry: 1.0
species: 303290

303542
type: Reaction
kinetic law: 006826
reactant: 006814
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Cysteine exchange

305132
type: LocalParameter
units: 006281
value: 0.0

305129
type: LocalParameter
units: 006281
value: 0.0

305126
type: LocalParameter
units: 006281
value: 0.0

305123
type: LocalParameter
units: 006281
value: -0.08

006814
type: SpeciesReference
stoichiometry: 1.0
species: 303317

304329
type: Reaction
reactant: 020507
fast: false
product: 020544
reactant: 020495
notes: GENE_ASSOCIATION: Lgals13 or Pla2g4a.1 or Clc.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 020532
product: 020519
name: lysophospholipase (C16:0)
kinetic law: 020556
reversible: false

020507
type: SpeciesReference
stoichiometry: 1.0
species: 302882

302882
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidylcholine (homo sapiens, C16:0)

020544
type: SpeciesReference
stoichiometry: 1.0
species: 302834

020495
type: SpeciesReference
stoichiometry: 1.0
species: 302822

020532
type: SpeciesReference
stoichiometry: 1.0
species: 302819

020519
type: SpeciesReference
stoichiometry: 1.0
species: 302753

308283
type: LocalParameter
units: 006281
value: 0.0

308280
type: LocalParameter
units: 006281
value: 0.0

308277
type: LocalParameter
units: 006281
value: 1000.0

308274
type: LocalParameter
units: 006281
value: 0.0

303479
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Urea

304808
type: Reaction
kinetic law: 030756
product: 030744
reactant: 030732
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: spermidine transport (faciliated)

309847
type: LocalParameter
units: 006281
value: 0.0

309845
type: LocalParameter
units: 006281
value: 0.0

309843
type: LocalParameter
units: 006281
value: 1000.0

309841
type: LocalParameter
units: 006281
value: -1000.0

030744
type: SpeciesReference
stoichiometry: 1.0
species: 303197

030732
type: SpeciesReference
stoichiometry: 1.0
species: 303467

303467
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Spermidine

304539
type: Reaction
kinetic law: 024793
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false
reactant: 024744
product: 024769
product: 024781
reactant: 024757
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:2, C18:1)

309122
type: LocalParameter
units: 006281
value: 0.0

309119
type: LocalParameter
units: 006281
value: 0.0

309116
type: LocalParameter
units: 006281
value: 1000.0

309113
type: LocalParameter
units: 006281
value: 0.0

024744
type: SpeciesReference
stoichiometry: 1.0
species: 302822

024769
type: SpeciesReference
stoichiometry: 1.0
species: 303050

024781
type: SpeciesReference
stoichiometry: 1.0
species: 303131

024757
type: SpeciesReference
stoichiometry: 1.0
species: 303029

303383
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Inosine

304736
type: Reaction
name: purine-nucleoside phosphorylase (Adenosine)
kinetic law: 029223
product: 029199
fast: false
product: 029211
reactant: 029186
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 029174

309655
type: LocalParameter
units: 006281
value: 0.0

309653
type: LocalParameter
units: 006281
value: 0.0

309651
type: LocalParameter
units: 006281
value: 1000.0

309649
type: LocalParameter
units: 006281
value: -1000.0

029199
type: SpeciesReference
stoichiometry: 1.0
species: 302544

029211
type: SpeciesReference
stoichiometry: 1.0
species: 303176

029186
type: SpeciesReference
stoichiometry: 1.0
species: 303131

029174
type: SpeciesReference
stoichiometry: 1.0
species: 302547

302547
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Adenosine

304221
type: Reaction
reactant: 018321
kinetic law: 018357
product: 018333
fast: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Ascorbate and Aldarate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 018309
product: 018345
name: Glutathione dehydrogenase (dehydroascorbate reductase)

018321
type: SpeciesReference
stoichiometry: 2.0
species: 302807

307851
type: LocalParameter
units: 006281
value: 0.0

307848
type: LocalParameter
units: 006281
value: 0.0

307845
type: LocalParameter
units: 006281
value: 1000.0

307842
type: LocalParameter
units: 006281
value: 0.0

018333
type: SpeciesReference
stoichiometry: 1.0
species: 302586

302586
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Ascorbate

018309
type: SpeciesReference
stoichiometry: 1.0
species: 302699

018345
type: SpeciesReference
stoichiometry: 1.0
species: 302804

304763
type: Reaction
kinetic law: 029789
product: 029777
reactant: 029765
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: pyridoxine transport via diffusion

309727
type: LocalParameter
units: 006281
value: 0.0

309725
type: LocalParameter
units: 006281
value: 0.0

309723
type: LocalParameter
units: 006281
value: 1000.0

309721
type: LocalParameter
units: 006281
value: -1000.0

029777
type: SpeciesReference
stoichiometry: 1.0
species: 303170

303170
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Pyridoxine

029765
type: SpeciesReference
stoichiometry: 1.0
species: 303458

303458
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Pyridoxine

303725
type: Reaction
kinetic law: 008304
reactant: 008292
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink mi1345p(c)

305861
type: LocalParameter
units: 006281
value: 0.0

305858
type: LocalParameter
units: 006281
value: 0.0

305855
type: LocalParameter
units: 006281
value: 10.0

305852
type: LocalParameter
units: 006281
value: -10.0

008292
type: SpeciesReference
stoichiometry: 1.0
species: 302909

303483
type: Reaction
kinetic law: 006341
reactant: 006329
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 3',5'-Cyclic GMP exchange

304892
type: LocalParameter
units: 006281
value: 0.0

304889
type: LocalParameter
units: 006281
value: 0.0

304886
type: LocalParameter
units: 006281
value: 0.024

304884
type: LocalParameter
units: 006281
value: 0.0

006329
type: SpeciesReference
stoichiometry: 1.0
species: 303257

304182
type: Reaction
name: L-glutamine reversible transport via sodium symport
product: 017388
reversible: false
notes: GENE_ASSOCIATION: Slc38a4.1 or Slc38a1.1 or Slc6a14.1 or Slc38a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 017401
reactant: 017364
fast: false
reactant: 017352
product: 017376

017388
type: SpeciesReference
stoichiometry: 1.0
species: 302927

307695
type: LocalParameter
units: 006281
value: 0.0

307692
type: LocalParameter
units: 006281
value: 0.0

307689
type: LocalParameter
units: 006281
value: 1000.0

307686
type: LocalParameter
units: 006281
value: 0.0

017364
type: SpeciesReference
stoichiometry: 1.0
species: 303416

017352
type: SpeciesReference
stoichiometry: 1.0
species: 303347

017376
type: SpeciesReference
stoichiometry: 1.0
species: 302780

304431
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 022549
fast: false
reactant: 022573
kinetic law: 022633
reactant: 022561
product: 022621
product: 022597
name: L-Normetanephrine seceretion via secretory vesicle (ATP driven)
product: 022585
product: 022609

022549
type: SpeciesReference
stoichiometry: 2.0
species: 302589

022573
type: SpeciesReference
stoichiometry: 3.0
species: 302960

308691
type: LocalParameter
units: 006281
value: 0.0

308688
type: LocalParameter
units: 006281
value: 0.0

308685
type: LocalParameter
units: 006281
value: 1000.0

308682
type: LocalParameter
units: 006281
value: 0.0

022561
type: SpeciesReference
stoichiometry: 2.0
species: 302822

022621
type: SpeciesReference
stoichiometry: 3.0
species: 303428

303428
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Normetanephrine

022597
type: SpeciesReference
stoichiometry: 2.0
species: 302819

022585
type: SpeciesReference
stoichiometry: 2.0
species: 302549

022609
type: SpeciesReference
stoichiometry: 2.0
species: 303131

303863
type: Reaction
reactant: 010403
kinetic law: 010439
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
product: 010415
fast: false
reversible: false
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:2,C16:0)
product: 010427
reactant: 010391

010403
type: SpeciesReference
stoichiometry: 1.0
species: 303134

306413
type: LocalParameter
units: 006281
value: 0.0

306410
type: LocalParameter
units: 006281
value: 0.0

306407
type: LocalParameter
units: 006281
value: 1000.0

306404
type: LocalParameter
units: 006281
value: 0.0

010415
type: SpeciesReference
stoichiometry: 1.0
species: 302660

010427
type: SpeciesReference
stoichiometry: 1.0
species: 303005

010391
type: SpeciesReference
stoichiometry: 1.0
species: 302570

303890
type: Reaction
name: arginase
reactant: 011022
fast: false
notes: GENE_ASSOCIATION: Arg1.1 SUBSYSTEM: Urea cycle/amino group metabolism EC Number: Confidence Level: AUTHORS:
product: 011046
kinetic law: 011058
reversible: false
reactant: 011010
product: 011034

011022
type: SpeciesReference
stoichiometry: 1.0
species: 302822

011046
type: SpeciesReference
stoichiometry: 1.0
species: 303233

306521
type: LocalParameter
units: 006281
value: 0.0

306518
type: LocalParameter
units: 006281
value: 0.0

306515
type: LocalParameter
units: 006281
value: 1000.0

306512
type: LocalParameter
units: 006281
value: 0.0

011010
type: SpeciesReference
stoichiometry: 1.0
species: 302583

011034
type: SpeciesReference
stoichiometry: 1.0
species: 302981

304227
type: Reaction
product: 018503
reactant: 018443
product: 018515
reactant: 018455
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
product: 018479
fast: false
reactant: 018467
reversible: false
product: 018491
kinetic law: 018527
name: oxidized glutathione irreversible active transport (rbc)

018503
type: SpeciesReference
stoichiometry: 1.0
species: 303131

018443
type: SpeciesReference
stoichiometry: 1.0
species: 302589

018515
type: SpeciesReference
stoichiometry: 1.0
species: 303359

018455
type: SpeciesReference
stoichiometry: 1.0
species: 302804

018479
type: SpeciesReference
stoichiometry: 1.0
species: 302549

018467
type: SpeciesReference
stoichiometry: 1.0
species: 302822

018491
type: SpeciesReference
stoichiometry: 1.0
species: 302819

307875
type: LocalParameter
units: 006281
value: 0.0

307872
type: LocalParameter
units: 006281
value: 0.0

307869
type: LocalParameter
units: 006281
value: 1000.0

307866
type: LocalParameter
units: 006281
value: 0.0

302561
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Alanine

304677
type: Reaction
fast: false
reactant: 027952
reactant: 027964
product: 027976
product: 028000
product: 027988
kinetic law: 028012
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
name: phospholipase A2 (C16:0,C18:2)

027952
type: SpeciesReference
stoichiometry: 1.0
species: 302822

027964
type: SpeciesReference
stoichiometry: 1.0
species: 303080

027976
type: SpeciesReference
stoichiometry: 1.0
species: 302819

028000
type: SpeciesReference
stoichiometry: 1.0
species: 302882

027988
type: SpeciesReference
stoichiometry: 1.0
species: 302873

309495
type: LocalParameter
units: 006281
value: 0.0

309493
type: LocalParameter
units: 006281
value: 0.0

309491
type: LocalParameter
units: 006281
value: 1000.0

309489
type: LocalParameter
units: 006281
value: 0.0

302473
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3-Phospho-D-glyceroyl phosphate

302487
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 3-Dehydro-L-gulonate

303659
type: Reaction
kinetic law: 007771
reactant: 007759
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: O2 exchange

305597
type: LocalParameter
units: 006281
value: 0.0

305594
type: LocalParameter
units: 006281
value: 0.0

305591
type: LocalParameter
units: 006281
value: 5.0000775

305588
type: LocalParameter
units: 006281
value: -0.0943609999999993

007759
type: SpeciesReference
stoichiometry: 1.0
species: 303434

303908
type: Reaction
reactant: 011338
fast: false
reversible: false
reactant: 011350
notes: GENE_ASSOCIATION: Ugt1A1.1 or Ugt1A4.1 SUBSYSTEM: Heme Degradation EC Number: Confidence Level: AUTHORS:
name: bilirubin UDP-glucuronosyltransferase
product: 011374
product: 011386
kinetic law: 011399
reactant: 011362

011338
type: SpeciesReference
stoichiometry: 1.0
species: 302600

011350
type: SpeciesReference
stoichiometry: 2.0
species: 302819

011374
type: SpeciesReference
stoichiometry: 1.0
species: 302597

011386
type: SpeciesReference
stoichiometry: 1.0
species: 303215

306593
type: LocalParameter
units: 006281
value: 0.0

306590
type: LocalParameter
units: 006281
value: 0.0

306587
type: LocalParameter
units: 006281
value: 1000.0

306584
type: LocalParameter
units: 006281
value: 0.0

011362
type: SpeciesReference
stoichiometry: 1.0
species: 303224

304392
type: Reaction
kinetic law: 021737
product: 021725
reactant: 021713
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Nicotinic acid uptake

308535
type: LocalParameter
units: 006281
value: 0.0

308532
type: LocalParameter
units: 006281
value: 0.0

308529
type: LocalParameter
units: 006281
value: 1000.0

308526
type: LocalParameter
units: 006281
value: -1000.0

021725
type: SpeciesReference
stoichiometry: 1.0
species: 302930

021713
type: SpeciesReference
stoichiometry: 1.0
species: 303419

303419
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Nicotinate

304365
type: Reaction
kinetic law: 021268
product: 021256
reactant: 021244
notes: GENE_ASSOCIATION: Slc43a1.1 or Slc43a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-methionine transport via diffusion (extracellular to cytosol)

308427
type: LocalParameter
units: 006281
value: 0.0

308424
type: LocalParameter
units: 006281
value: 0.0

308421
type: LocalParameter
units: 006281
value: 1000.0

308418
type: LocalParameter
units: 006281
value: -1000.0

021256
type: SpeciesReference
stoichiometry: 1.0
species: 302906

302906
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Methionine

021244
type: SpeciesReference
stoichiometry: 1.0
species: 303413

303869
type: Reaction
product: 010537
reversible: true
reactant: 010525
fast: false
notes: GENE_ASSOCIATION: Ahcy.1 SUBSYSTEM: Methionine Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 010513
kinetic law: 010561
name: adenosylhomocysteinase
product: 010549

010537
type: SpeciesReference
stoichiometry: 1.0
species: 302547

010525
type: SpeciesReference
stoichiometry: 1.0
species: 302822

010513
type: SpeciesReference
stoichiometry: 1.0
species: 302556

306437
type: LocalParameter
units: 006281
value: 0.0

306434
type: LocalParameter
units: 006281
value: 0.0

306431
type: LocalParameter
units: 006281
value: 1000.0

306428
type: LocalParameter
units: 006281
value: -1000.0

010549
type: SpeciesReference
stoichiometry: 1.0
species: 302831

303551
type: Reaction
kinetic law: 006898
reactant: 006886
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Ethanolamine exchange

305165
type: LocalParameter
units: 006281
value: 0.0

305162
type: LocalParameter
units: 006281
value: 0.0

305159
type: LocalParameter
units: 006281
value: 0.0

305156
type: LocalParameter
units: 006281
value: -0.012

006886
type: SpeciesReference
stoichiometry: 1.0
species: 303326

302567
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: lysophosphatidic acid (homo sapiens, C18:1)

303761
type: Reaction
kinetic law: 008593
reactant: 008581
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pe hs 16 0 18 1(c)

306005
type: LocalParameter
units: 006281
value: 0.0

306002
type: LocalParameter
units: 006281
value: 0.0

305999
type: LocalParameter
units: 006281
value: 10.0

305996
type: LocalParameter
units: 006281
value: -10.0

008581
type: SpeciesReference
stoichiometry: 1.0
species: 303101

304073
type: Reaction
reversible: true
fast: false
kinetic law: 015210
reactant: 015162
name: Diacylglycerol phosphate kinase (homo sapiens, C18:2,C18:1)
product: 015198
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 015186
product: 015174
reactant: 015150

307251
type: LocalParameter
units: 006281
value: 0.0

307248
type: LocalParameter
units: 006281
value: 0.0

307245
type: LocalParameter
units: 006281
value: 1000.0

307242
type: LocalParameter
units: 006281
value: -1000.0

015162
type: SpeciesReference
stoichiometry: 1.0
species: 302693

015198
type: SpeciesReference
stoichiometry: 1.0
species: 303008

015186
type: SpeciesReference
stoichiometry: 1.0
species: 302819

015174
type: SpeciesReference
stoichiometry: 1.0
species: 302549

015150
type: SpeciesReference
stoichiometry: 1.0
species: 302589

304575
type: Reaction
product: 025625
reactant: 025601
name: phosphatidylinositol 4-phosphate 5-kinase (C18:1,C18:2)
fast: false
reactant: 025613
kinetic law: 025661
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 025637
product: 025649

025625
type: SpeciesReference
stoichiometry: 1.0
species: 302549

025601
type: SpeciesReference
stoichiometry: 1.0
species: 302589

025613
type: SpeciesReference
stoichiometry: 1.0
species: 303044

309223
type: LocalParameter
units: 006281
value: 0.0

309221
type: LocalParameter
units: 006281
value: 0.0

309219
type: LocalParameter
units: 006281
value: 1000.0

309217
type: LocalParameter
units: 006281
value: 0.0

025637
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025649
type: SpeciesReference
stoichiometry: 1.0
species: 303023

304548
type: Reaction
fast: false
reactant: 024949
reactant: 024961
product: 024985
kinetic law: 025009
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C18:2)
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 024973
product: 024997

024949
type: SpeciesReference
stoichiometry: 1.0
species: 302822

024961
type: SpeciesReference
stoichiometry: 1.0
species: 303017

024985
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309151
type: LocalParameter
units: 006281
value: 0.0

309149
type: LocalParameter
units: 006281
value: 0.0

309147
type: LocalParameter
units: 006281
value: 1000.0

309145
type: LocalParameter
units: 006281
value: 0.0

024973
type: SpeciesReference
stoichiometry: 1.0
species: 302681

024997
type: SpeciesReference
stoichiometry: 1.0
species: 302915

304772
type: Reaction
notes: GENE_ASSOCIATION: Pkm2.1 or Pklr.2 or Pklr.1 or Pkm2.3 or Pkm2.2 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reactant: 029911
product: 029947
name: pyruvate kinase
reactant: 029899
reactant: 029923
kinetic law: 029960
reversible: false
product: 029935

029911
type: SpeciesReference
stoichiometry: 1.0
species: 302819

029947
type: SpeciesReference
stoichiometry: 1.0
species: 303173

029899
type: SpeciesReference
stoichiometry: 1.0
species: 302549

029923
type: SpeciesReference
stoichiometry: 1.0
species: 303119

309751
type: LocalParameter
units: 006281
value: 0.0

309749
type: LocalParameter
units: 006281
value: 0.0

309747
type: LocalParameter
units: 006281
value: 1000.0

309745
type: LocalParameter
units: 006281
value: 0.0

029935
type: SpeciesReference
stoichiometry: 1.0
species: 302589

303557
type: Reaction
kinetic law: 006946
reactant: 006934
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: D-Fructose exchange

305189
type: LocalParameter
units: 006281
value: 0.0

305186
type: LocalParameter
units: 006281
value: 0.0

305183
type: LocalParameter
units: 006281
value: 1.12

305180
type: LocalParameter
units: 006281
value: -0.0075

006934
type: SpeciesReference
stoichiometry: 1.0
species: 303332

303734
type: Reaction
kinetic law: 008377
reactant: 008364
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink mi14p(c)

305897
type: LocalParameter
units: 006281
value: 0.0

305894
type: LocalParameter
units: 006281
value: 0.0

305891
type: LocalParameter
units: 006281
value: 10.0

305888
type: LocalParameter
units: 006281
value: -10.0

008364
type: SpeciesReference
stoichiometry: 1.0
species: 302918

304299
type: Reaction
kinetic law: 020014
product: 020001
reactant: 019989
notes: GENE_ASSOCIATION: Slc29a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Inosine transport (diffusion)

308163
type: LocalParameter
units: 006281
value: 0.0

308160
type: LocalParameter
units: 006281
value: 0.0

308157
type: LocalParameter
units: 006281
value: 1000.0

308154
type: LocalParameter
units: 006281
value: -1000.0

020001
type: SpeciesReference
stoichiometry: 1.0
species: 302852

019989
type: SpeciesReference
stoichiometry: 1.0
species: 303383

302987
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Orotidine 5'-phosphate

304010
type: Reaction
fast: false
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: ethanolamine phosphotransferase (C18:1,C18:1)
reversible: false
product: 013790
product: 013778
reactant: 013754
reactant: 013742
kinetic law: 013802
product: 013766

013790
type: SpeciesReference
stoichiometry: 1.0
species: 303107

013778
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013754
type: SpeciesReference
stoichiometry: 1.0
species: 302684

013742
type: SpeciesReference
stoichiometry: 1.0
species: 302639

307001
type: LocalParameter
units: 006281
value: 0.0

306998
type: LocalParameter
units: 006281
value: 0.0

306995
type: LocalParameter
units: 006281
value: 1000.0

306992
type: LocalParameter
units: 006281
value: 0.0

013766
type: SpeciesReference
stoichiometry: 1.0
species: 302651

304778
type: Reaction
name: riboflavin kinase
reactant: 030033
notes: GENE_ASSOCIATION: Rfk.1 SUBSYSTEM: Riboflavin Metabolism EC Number: Confidence Level: AUTHORS:
product: 030081
product: 030057
product: 030069
reversible: false
reactant: 030045
kinetic law: 030093
fast: false

030033
type: SpeciesReference
stoichiometry: 1.0
species: 302589

030081
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030057
type: SpeciesReference
stoichiometry: 1.0
species: 302549

030069
type: SpeciesReference
stoichiometry: 1.0
species: 302736

030045
type: SpeciesReference
stoichiometry: 1.0
species: 303182

309767
type: LocalParameter
units: 006281
value: 0.0

309765
type: LocalParameter
units: 006281
value: 0.0

309763
type: LocalParameter
units: 006281
value: 1000.0

309761
type: LocalParameter
units: 006281
value: 0.0

303485
type: Reaction
kinetic law: 006365
reactant: 006353
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 3-Methoxytyramine exchange

304904
type: LocalParameter
units: 006281
value: 0.0

304901
type: LocalParameter
units: 006281
value: 0.0

304898
type: LocalParameter
units: 006281
value: 0.0324

304895
type: LocalParameter
units: 006281
value: 0.0

006353
type: SpeciesReference
stoichiometry: 1.0
species: 303260

303260
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 3-Methoxytyramine

304191
type: Reaction
name: glycerol kinase
product: 017594
notes: GENE_ASSOCIATION: Gkp3.1 or Gk.1 or Gk.2 or Gk2.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 017606
product: 017570
fast: false
reactant: 017557
reactant: 017545
product: 017582
reversible: false

017594
type: SpeciesReference
stoichiometry: 1.0
species: 302819

307731
type: LocalParameter
units: 006281
value: 0.0

307728
type: LocalParameter
units: 006281
value: 0.0

307725
type: LocalParameter
units: 006281
value: 1000.0

307722
type: LocalParameter
units: 006281
value: 0.0

017570
type: SpeciesReference
stoichiometry: 1.0
species: 302549

017557
type: SpeciesReference
stoichiometry: 1.0
species: 302792

017545
type: SpeciesReference
stoichiometry: 1.0
species: 302589

017582
type: SpeciesReference
stoichiometry: 1.0
species: 302795

304518
type: Reaction
kinetic law: 024369
product: 024357
reactant: 024345
notes: GENE_ASSOCIATION: Slc43a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-phenylalanine transport via diffusion (extracellular to cytosol)

309039
type: LocalParameter
units: 006281
value: 0.0

309036
type: LocalParameter
units: 006281
value: 0.0

309033
type: LocalParameter
units: 006281
value: 1000.0

309030
type: LocalParameter
units: 006281
value: -1000.0

024357
type: SpeciesReference
stoichiometry: 1.0
species: 303122

303122
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: L-Phenylalanine

024345
type: SpeciesReference
stoichiometry: 1.0
species: 303443

304236
type: Reaction
kinetic law: 018739
product: 018727
product: 018715
reactant: 018703
notes: GENE_ASSOCIATION: Gucy2D.1 or Gucy1A2B3.1 or Gucy1A2B2.1 or Gucy1A3B2.1 or Gucy2F.1 or Npr2.1 or Gucy1A3B3.1 or Gucy2C.1 or Npr2.2 or Npr1.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: guanylate cyclase

307911
type: LocalParameter
units: 006281
value: 0.0

307908
type: LocalParameter
units: 006281
value: 0.0

307905
type: LocalParameter
units: 006281
value: 1000.0

307902
type: LocalParameter
units: 006281
value: 0.0

018727
type: SpeciesReference
stoichiometry: 1.0
species: 303143

018715
type: SpeciesReference
stoichiometry: 1.0
species: 302484

018703
type: SpeciesReference
stoichiometry: 1.0
species: 302810

302810
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: GTP

303704
type: Reaction
kinetic law: 008135
reactant: 008123
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Urea exchange

305777
type: LocalParameter
units: 006281
value: 0.0

305774
type: LocalParameter
units: 006281
value: 0.0

305771
type: LocalParameter
units: 006281
value: 0.1152

305768
type: LocalParameter
units: 006281
value: 0.0

008123
type: SpeciesReference
stoichiometry: 1.0
species: 303479

303668
type: Reaction
kinetic law: 007843
reactant: 007831
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-Phenylalanine exchange

305633
type: LocalParameter
units: 006281
value: 0.0

305630
type: LocalParameter
units: 006281
value: 0.0

305627
type: LocalParameter
units: 006281
value: 10.0

305624
type: LocalParameter
units: 006281
value: -10.0

007831
type: SpeciesReference
stoichiometry: 1.0
species: 303443

303695
type: Reaction
kinetic law: 008062
reactant: 008050
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Spermine exchange

305741
type: LocalParameter
units: 006281
value: 0.0

305738
type: LocalParameter
units: 006281
value: 0.0

305735
type: LocalParameter
units: 006281
value: 0.0400000685

305732
type: LocalParameter
units: 006281
value: 0.0

008050
type: SpeciesReference
stoichiometry: 1.0
species: 303470

304410
type: Reaction
product: 022126
notes: GENE_ASSOCIATION: NME12.2 or NME12.1 or NME3.1 or NME7.2 or NME6.1 or NME7.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
name: nucleoside-diphosphate kinase (ATP:GDP)
reactant: 022090
kinetic law: 022138
product: 022114
reversible: true
reactant: 022102
fast: false

022126
type: SpeciesReference
stoichiometry: 1.0
species: 302810

022090
type: SpeciesReference
stoichiometry: 1.0
species: 302589

308607
type: LocalParameter
units: 006281
value: 0.0

308604
type: LocalParameter
units: 006281
value: 0.0

308601
type: LocalParameter
units: 006281
value: 1000.0

308598
type: LocalParameter
units: 006281
value: -1000.0

022114
type: SpeciesReference
stoichiometry: 1.0
species: 302549

022102
type: SpeciesReference
stoichiometry: 1.0
species: 302772

302772
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: GDP

304197
type: Reaction
product: 017753
name: glycine reversible transport via sodium and chloride symport (2:1:1)
product: 017740
reactant: 017715
product: 017727
reversible: true
fast: false
reactant: 017703
kinetic law: 017765
notes: GENE_ASSOCIATION: Slc6a9.1 or Slc6a9.2 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 017691

017753
type: SpeciesReference
stoichiometry: 2.0
species: 302927

017740
type: SpeciesReference
stoichiometry: 1.0
species: 302789

017715
type: SpeciesReference
stoichiometry: 2.0
species: 303416

017727
type: SpeciesReference
stoichiometry: 1.0
species: 302648

017703
type: SpeciesReference
stoichiometry: 1.0
species: 303353

307755
type: LocalParameter
units: 006281
value: 0.0

307752
type: LocalParameter
units: 006281
value: 0.0

307749
type: LocalParameter
units: 006281
value: 1000.0

307746
type: LocalParameter
units: 006281
value: -1000.0

017691
type: SpeciesReference
stoichiometry: 1.0
species: 303308

304620
type: Reaction
reactant: 026630
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol-4-phosphate 4-phosphatase (C18:2,C16:0)
product: 026667
fast: false
product: 026655
reversible: false
kinetic law: 026679
reactant: 026643

026630
type: SpeciesReference
stoichiometry: 1.0
species: 302822

026667
type: SpeciesReference
stoichiometry: 1.0
species: 303131

026655
type: SpeciesReference
stoichiometry: 1.0
species: 303068

309343
type: LocalParameter
units: 006281
value: 0.0

309341
type: LocalParameter
units: 006281
value: 0.0

309339
type: LocalParameter
units: 006281
value: 1000.0

309337
type: LocalParameter
units: 006281
value: 0.0

026643
type: SpeciesReference
stoichiometry: 1.0
species: 303047

302897
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Mannose 1-phosphate

304206
type: Reaction
reactant: 017983
notes: GENE_ASSOCIATION: Pgd.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
reactant: 017995
product: 018031
product: 018007
name: phosphogluconate dehydrogenase
reversible: false
product: 018019
kinetic law: 018043
fast: false

017983
type: SpeciesReference
stoichiometry: 1.0
species: 302514

017995
type: SpeciesReference
stoichiometry: 1.0
species: 302939

018031
type: SpeciesReference
stoichiometry: 1.0
species: 303188

018007
type: SpeciesReference
stoichiometry: 1.0
species: 302657

018019
type: SpeciesReference
stoichiometry: 1.0
species: 302942

307791
type: LocalParameter
units: 006281
value: 0.0

307788
type: LocalParameter
units: 006281
value: 0.0

307785
type: LocalParameter
units: 006281
value: 1000.0

307782
type: LocalParameter
units: 006281
value: 0.0

303011
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidylinositol 4,5-bisphosphate (homo sapiens, C16:0, C16:0)

304082
type: Reaction
kinetic law: 015355
product: 015343
product: 015331
reactant: 015319
notes: GENE_ASSOCIATION: SUBSYSTEM: ' EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: demand NADH

307287
type: LocalParameter
units: 006281
value: 0.0

307284
type: LocalParameter
units: 006281
value: 0.0

307281
type: LocalParameter
units: 006281
value: 1000.0

307278
type: LocalParameter
units: 006281
value: 0.0

015343
type: SpeciesReference
stoichiometry: 1.0
species: 302933

015331
type: SpeciesReference
stoichiometry: 1.0
species: 302819

015319
type: SpeciesReference
stoichiometry: 1.0
species: 302936

304344
type: Reaction
kinetic law: 020822
product: 020810
reactant: 020797
notes: GENE_ASSOCIATION: Mpi.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: mannose-6-phosphate isomerase

308343
type: LocalParameter
units: 006281
value: 0.0

308340
type: LocalParameter
units: 006281
value: 0.0

308337
type: LocalParameter
units: 006281
value: 1000.0

308334
type: LocalParameter
units: 006281
value: -1000.0

020810
type: SpeciesReference
stoichiometry: 1.0
species: 302726

020797
type: SpeciesReference
stoichiometry: 1.0
species: 302900

303503
type: Reaction
kinetic law: 006509
reactant: 006497
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Adenine exchange

304976
type: LocalParameter
units: 006281
value: 0.0

304973
type: LocalParameter
units: 006281
value: 0.0

304970
type: LocalParameter
units: 006281
value: 0.01

304967
type: LocalParameter
units: 006281
value: -0.014

006497
type: SpeciesReference
stoichiometry: 1.0
species: 303278

303530
type: Reaction
kinetic law: 006727
reactant: 006715
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Choline exchange

305084
type: LocalParameter
units: 006281
value: 0.0

305081
type: LocalParameter
units: 006281
value: 0.0

305078
type: LocalParameter
units: 006281
value: 0.0

305075
type: LocalParameter
units: 006281
value: -0.012

006715
type: SpeciesReference
stoichiometry: 1.0
species: 303305

303740
type: Reaction
kinetic law: 008425
reactant: 008413
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pchol hs 16 0 18 1(c)

305921
type: LocalParameter
units: 006281
value: 0.0

305918
type: LocalParameter
units: 006281
value: 0.0

305915
type: LocalParameter
units: 006281
value: 10.0

305912
type: LocalParameter
units: 006281
value: -10.0

008413
type: SpeciesReference
stoichiometry: 1.0
species: 303077

304317
type: Reaction
kinetic law: 020326
product: 020314
reactant: 020302
reactant: 020290
notes: GENE_ASSOCIATION: Glo1.1 SUBSYSTEM: Pyruvate Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: lactoylglutathione lyase

308235
type: LocalParameter
units: 006281
value: 0.0

308232
type: LocalParameter
units: 006281
value: 0.0

308229
type: LocalParameter
units: 006281
value: 1000.0

308226
type: LocalParameter
units: 006281
value: 0.0

020314
type: SpeciesReference
stoichiometry: 1.0
species: 302870

020302
type: SpeciesReference
stoichiometry: 1.0
species: 302924

020290
type: SpeciesReference
stoichiometry: 1.0
species: 302807

304527
type: Reaction
product: 024526
reactant: 024502
reactant: 024514
product: 024538
fast: false
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
kinetic law: 024551
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C18:2)

024526
type: SpeciesReference
stoichiometry: 1.0
species: 303038

024502
type: SpeciesReference
stoichiometry: 1.0
species: 302822

024514
type: SpeciesReference
stoichiometry: 1.0
species: 303017

024538
type: SpeciesReference
stoichiometry: 1.0
species: 303131

309075
type: LocalParameter
units: 006281
value: 0.0

309072
type: LocalParameter
units: 006281
value: 0.0

309069
type: LocalParameter
units: 006281
value: 1000.0

309066
type: LocalParameter
units: 006281
value: 0.0

304088
type: Reaction
kinetic law: 015463
product: 015451
reactant: 015439
notes: GENE_ASSOCIATION: Slc22a2.1 or Slc22a2.2 or Slc22a3.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Dopamine uniport

307311
type: LocalParameter
units: 006281
value: 0.0

307308
type: LocalParameter
units: 006281
value: 0.0

307305
type: LocalParameter
units: 006281
value: 1000.0

307302
type: LocalParameter
units: 006281
value: -1000.0

015451
type: SpeciesReference
stoichiometry: 1.0
species: 302711

015439
type: SpeciesReference
stoichiometry: 1.0
species: 303323

304554
type: Reaction
reactant: 025106
product: 025143
reversible: false
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:1, C18:2)
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 025094
product: 025131
kinetic law: 025155
product: 025118
fast: false

025106
type: SpeciesReference
stoichiometry: 1.0
species: 303023

025143
type: SpeciesReference
stoichiometry: 1.0
species: 302915

025094
type: SpeciesReference
stoichiometry: 1.0
species: 302822

025131
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309167
type: LocalParameter
units: 006281
value: 0.0

309165
type: LocalParameter
units: 006281
value: 0.0

309163
type: LocalParameter
units: 006281
value: 1000.0

309161
type: LocalParameter
units: 006281
value: 0.0

025118
type: SpeciesReference
stoichiometry: 1.0
species: 302687

304724
type: Reaction
kinetic law: 028991
product: 028979
reactant: 028966
notes: GENE_ASSOCIATION: Pgm1.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: phosphopentomutase

309623
type: LocalParameter
units: 006281
value: 0.0

309621
type: LocalParameter
units: 006281
value: 0.0

309619
type: LocalParameter
units: 006281
value: 1000.0

309617
type: LocalParameter
units: 006281
value: -1000.0

028979
type: SpeciesReference
stoichiometry: 1.0
species: 303179

028966
type: SpeciesReference
stoichiometry: 1.0
species: 303176

304751
type: Reaction
kinetic law: 029535
product: 029523
reactant: 029511
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: pyridoxamine transport via diffusion

309695
type: LocalParameter
units: 006281
value: 0.0

309693
type: LocalParameter
units: 006281
value: 0.0

309691
type: LocalParameter
units: 006281
value: 1000.0

309689
type: LocalParameter
units: 006281
value: -1000.0

029523
type: SpeciesReference
stoichiometry: 1.0
species: 303161

029511
type: SpeciesReference
stoichiometry: 1.0
species: 303452

303452
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Pyridoxamine

303713
type: Reaction
kinetic law: 008207
reactant: 008195
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink akg(c)

305813
type: LocalParameter
units: 006281
value: 0.0

305810
type: LocalParameter
units: 006281
value: 0.0

305807
type: LocalParameter
units: 006281
value: 10.0

305804
type: LocalParameter
units: 006281
value: -10.0

008195
type: SpeciesReference
stoichiometry: 1.0
species: 302558

303986
type: Reaction
reactant: 013163
product: 013200
reactant: 013175
name: choline phosphotransferase (C16:0, C18:2)
reversible: false
fast: false
product: 013212
product: 013187
kinetic law: 013224
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:

013163
type: SpeciesReference
stoichiometry: 1.0
species: 302615

013200
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013175
type: SpeciesReference
stoichiometry: 1.0
species: 302681

013212
type: SpeciesReference
stoichiometry: 1.0
species: 303080

013187
type: SpeciesReference
stoichiometry: 1.0
species: 302651

306905
type: LocalParameter
units: 006281
value: 0.0

306902
type: LocalParameter
units: 006281
value: 0.0

306899
type: LocalParameter
units: 006281
value: 1000.0

306896
type: LocalParameter
units: 006281
value: 0.0

302499
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: 5-Amino-4-oxopentanoate

303437
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: octadecenoate (n-C18:1)

303509
type: Reaction
kinetic law: 006558
reactant: 006546
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Adrenaline exchange

305000
type: LocalParameter
units: 006281
value: 0.0

304997
type: LocalParameter
units: 006281
value: 0.0

304994
type: LocalParameter
units: 006281
value: 0.0

304991
type: LocalParameter
units: 006281
value: -0.0378

006546
type: SpeciesReference
stoichiometry: 1.0
species: 303284

304242
type: Reaction
kinetic law: 018873
reactant: 018812
notes: GENE_ASSOCIATION: Cryl1. SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
name: L-gulonate 3-dehydrogenase
reversible: true
reactant: 018824
product: 018837
fast: false
product: 018849
product: 018861

307935
type: LocalParameter
units: 006281
value: 0.0

307932
type: LocalParameter
units: 006281
value: 0.0

307929
type: LocalParameter
units: 006281
value: 1000.0

307926
type: LocalParameter
units: 006281
value: -1000.0

018812
type: SpeciesReference
stoichiometry: 1.0
species: 302816

018824
type: SpeciesReference
stoichiometry: 1.0
species: 302933

018837
type: SpeciesReference
stoichiometry: 1.0
species: 302487

018849
type: SpeciesReference
stoichiometry: 1.0
species: 302819

018861
type: SpeciesReference
stoichiometry: 1.0
species: 302936

304170
type: Reaction
kinetic law: 017148
product: 017136
product: 017124
reactant: 017111
notes: GENE_ASSOCIATION: Gctg.1 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: gamma-glutamylcyclotransferase

307647
type: LocalParameter
units: 006281
value: 0.0

307644
type: LocalParameter
units: 006281
value: 0.0

307641
type: LocalParameter
units: 006281
value: 1000.0

307638
type: LocalParameter
units: 006281
value: 0.0

017136
type: SpeciesReference
stoichiometry: 1.0
species: 302561

017124
type: SpeciesReference
stoichiometry: 1.0
species: 302511

017111
type: SpeciesReference
stoichiometry: 1.0
species: 303350

303959
type: Reaction
reactant: 012523
fast: false
reversible: false
reactant: 012511
kinetic law: 012571
product: 012559
product: 012547
reactant: 012535
name: phosphatidate cytidylyltransferase (C16:0, C16:0)
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:

012523
type: SpeciesReference
stoichiometry: 1.0
species: 302819

012511
type: SpeciesReference
stoichiometry: 1.0
species: 302669

306797
type: LocalParameter
units: 006281
value: 0.0

306794
type: LocalParameter
units: 006281
value: 0.0

306791
type: LocalParameter
units: 006281
value: 1000.0

306788
type: LocalParameter
units: 006281
value: 0.0

012559
type: SpeciesReference
stoichiometry: 1.0
species: 303143

012547
type: SpeciesReference
stoichiometry: 1.0
species: 302618

012535
type: SpeciesReference
stoichiometry: 1.0
species: 302990

303410
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Metanephrine

303851
type: Reaction
reactant: 010150
product: 010174
fast: false
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C18:1)
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reactant: 010162
product: 010186
reversible: false
kinetic law: 010198

010150
type: SpeciesReference
stoichiometry: 1.0
species: 302564

010174
type: SpeciesReference
stoichiometry: 1.0
species: 302660

010162
type: SpeciesReference
stoichiometry: 1.0
species: 302975

010186
type: SpeciesReference
stoichiometry: 1.0
species: 302993

306365
type: LocalParameter
units: 006281
value: 0.0

306362
type: LocalParameter
units: 006281
value: 0.0

306359
type: LocalParameter
units: 006281
value: 1000.0

306356
type: LocalParameter
units: 006281
value: 0.0

304215
type: Reaction
product: 018201
reactant: 018177
reversible: false
fast: false
reactant: 018189
product: 018213
notes: GENE_ASSOCIATION: Gpam.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
name: glycerol-3-phosphate acyltransferase (C18:2)
kinetic law: 018225

018201
type: SpeciesReference
stoichiometry: 1.0
species: 302570

018177
type: SpeciesReference
stoichiometry: 1.0
species: 302795

018189
type: SpeciesReference
stoichiometry: 1.0
species: 302876

018213
type: SpeciesReference
stoichiometry: 1.0
species: 302660

307827
type: LocalParameter
units: 006281
value: 0.0

307824
type: LocalParameter
units: 006281
value: 0.0

307821
type: LocalParameter
units: 006281
value: 1000.0

307818
type: LocalParameter
units: 006281
value: 0.0

304488
type: Reaction
product: 023802
product: 023814
name: Pyridoxine 5-phosphate phosphatase
kinetic law: 023826
reactant: 023790
fast: false
reactant: 023778
notes: GENE_ASSOCIATION: PdxP.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false

023802
type: SpeciesReference
stoichiometry: 1.0
species: 303131

023814
type: SpeciesReference
stoichiometry: 1.0
species: 303170

308919
type: LocalParameter
units: 006281
value: 0.0

308916
type: LocalParameter
units: 006281
value: 0.0

308913
type: LocalParameter
units: 006281
value: 1000.0

308910
type: LocalParameter
units: 006281
value: 0.0

023790
type: SpeciesReference
stoichiometry: 1.0
species: 303095

023778
type: SpeciesReference
stoichiometry: 1.0
species: 302822

302867
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Leukotriene B4

304665
type: Reaction
reversible: false
name: phosphatidylinositol phospholipase C (C18:2,C18:1)
product: 027716
reactant: 027692
product: 027728
reactant: 027704
product: 027740
fast: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 027752

027716
type: SpeciesReference
stoichiometry: 1.0
species: 302693

027692
type: SpeciesReference
stoichiometry: 1.0
species: 302822

027728
type: SpeciesReference
stoichiometry: 1.0
species: 302819

027704
type: SpeciesReference
stoichiometry: 1.0
species: 303071

027740
type: SpeciesReference
stoichiometry: 1.0
species: 302921

309463
type: LocalParameter
units: 006281
value: 0.0

309461
type: LocalParameter
units: 006281
value: 0.0

309459
type: LocalParameter
units: 006281
value: 1000.0

309457
type: LocalParameter
units: 006281
value: 0.0

303719
type: Reaction
kinetic law: 008256
reactant: 008244
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink bandmt(c)

305837
type: LocalParameter
units: 006281
value: 0.0

305834
type: LocalParameter
units: 006281
value: 0.0

305831
type: LocalParameter
units: 006281
value: 10.0

305828
type: LocalParameter
units: 006281
value: -10.0

008244
type: SpeciesReference
stoichiometry: 1.0
species: 302594

303647
type: Reaction
kinetic law: 007674
reactant: 007662
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Nicotinamide exchange

305549
type: LocalParameter
units: 006281
value: 0.0

305546
type: LocalParameter
units: 006281
value: 0.0

305543
type: LocalParameter
units: 006281
value: 0.001

305540
type: LocalParameter
units: 006281
value: 0.0

007662
type: SpeciesReference
stoichiometry: 1.0
species: 303422

303674
type: Reaction
kinetic law: 007892
reactant: 007880
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Putrescine exchange

305657
type: LocalParameter
units: 006281
value: 0.0

305654
type: LocalParameter
units: 006281
value: 0.0

305651
type: LocalParameter
units: 006281
value: 0.1152

305648
type: LocalParameter
units: 006281
value: 0.0

007880
type: SpeciesReference
stoichiometry: 1.0
species: 303449

303449
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Putrescine

304380
type: Reaction
kinetic law: 021568
reversible: false
fast: false
reactant: 021532
product: 021544
notes: GENE_ASSOCIATION: Impa1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 021520
product: 021556
name: myo-inositol 1-phosphatase

308487
type: LocalParameter
units: 006281
value: 0.0

308484
type: LocalParameter
units: 006281
value: 0.0

308481
type: LocalParameter
units: 006281
value: 1000.0

308478
type: LocalParameter
units: 006281
value: 0.0

021532
type: SpeciesReference
stoichiometry: 1.0
species: 302921

021544
type: SpeciesReference
stoichiometry: 1.0
species: 302849

021520
type: SpeciesReference
stoichiometry: 1.0
species: 302822

021556
type: SpeciesReference
stoichiometry: 1.0
species: 303131

304176
type: Reaction
kinetic law: 017244
product: 017232
reactant: 017220
notes: GENE_ASSOCIATION: Slc2a3.1-e or Slc2a1.1-e or Slc2a4.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: glucose transport (uniport)

307671
type: LocalParameter
units: 006281
value: 0.0

307668
type: LocalParameter
units: 006281
value: 0.0

307665
type: LocalParameter
units: 006281
value: 1000.0

307662
type: LocalParameter
units: 006281
value: -1000.0

017232
type: SpeciesReference
stoichiometry: 1.0
species: 302775

017220
type: SpeciesReference
stoichiometry: 1.0
species: 303344

304868
type: Reaction
product: 031926
notes: GENE_ASSOCIATION: Urod.1 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
kinetic law: 031950
product: 031938
reactant: 031914
reversible: false
reactant: 031902
fast: false
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)

031926
type: SpeciesReference
stoichiometry: 4.0
species: 302657

310007
type: LocalParameter
units: 006281
value: 0.0

310005
type: LocalParameter
units: 006281
value: 0.0

310003
type: LocalParameter
units: 006281
value: 1000.0

310001
type: LocalParameter
units: 006281
value: 0.0

031938
type: SpeciesReference
stoichiometry: 1.0
species: 302663

302663
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Coproporphyrinogen III

031914
type: SpeciesReference
stoichiometry: 1.0
species: 303230

031902
type: SpeciesReference
stoichiometry: 4.0
species: 302819

304353
type: Reaction
kinetic law: 020980
product: 020968
product: 020956
reactant: 020944
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate dehydratase

308379
type: LocalParameter
units: 006281
value: 0.0

308376
type: LocalParameter
units: 006281
value: 0.0

308373
type: LocalParameter
units: 006281
value: 1000.0

308370
type: LocalParameter
units: 006281
value: 0.0

020968
type: SpeciesReference
stoichiometry: 1.0
species: 302822

020956
type: SpeciesReference
stoichiometry: 1.0
species: 302705

020944
type: SpeciesReference
stoichiometry: 1.0
species: 302505

303857
type: Reaction
fast: false
reactant: 010270
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:1,C18:1)
kinetic law: 010319
product: 010307
product: 010295
reactant: 010282
reversible: false
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:

010270
type: SpeciesReference
stoichiometry: 1.0
species: 302567

306389
type: LocalParameter
units: 006281
value: 0.0

306386
type: LocalParameter
units: 006281
value: 0.0

306383
type: LocalParameter
units: 006281
value: 1000.0

306380
type: LocalParameter
units: 006281
value: 0.0

010307
type: SpeciesReference
stoichiometry: 1.0
species: 302999

010295
type: SpeciesReference
stoichiometry: 1.0
species: 302660

010282
type: SpeciesReference
stoichiometry: 1.0
species: 302975

304149
type: Reaction
name: galactokinase
product: 016683
notes: GENE_ASSOCIATION: Galk1.1 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
product: 016707
kinetic law: 016719
reactant: 016671
reactant: 016659
fast: false
reversible: false
product: 016695

016683
type: SpeciesReference
stoichiometry: 1.0
species: 302549

016707
type: SpeciesReference
stoichiometry: 1.0
species: 302819

307563
type: LocalParameter
units: 006281
value: 0.0

307560
type: LocalParameter
units: 006281
value: 0.0

307557
type: LocalParameter
units: 006281
value: 1000.0

307554
type: LocalParameter
units: 006281
value: 0.0

016671
type: SpeciesReference
stoichiometry: 1.0
species: 302759

016659
type: SpeciesReference
stoichiometry: 1.0
species: 302589

016695
type: SpeciesReference
stoichiometry: 1.0
species: 302762

304061
type: Reaction
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 014870
name: Diacylglycerol phosphate kinase (homo sapiens, C16:0, C18:2)
product: 014894
fast: false
reactant: 014858
product: 014882
kinetic law: 014919
product: 014906

014870
type: SpeciesReference
stoichiometry: 1.0
species: 302681

014894
type: SpeciesReference
stoichiometry: 1.0
species: 302819

014858
type: SpeciesReference
stoichiometry: 1.0
species: 302589

014882
type: SpeciesReference
stoichiometry: 1.0
species: 302549

307203
type: LocalParameter
units: 006281
value: 0.0

307200
type: LocalParameter
units: 006281
value: 0.0

307197
type: LocalParameter
units: 006281
value: 1000.0

307194
type: LocalParameter
units: 006281
value: -1000.0

014906
type: SpeciesReference
stoichiometry: 1.0
species: 302996

302996
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: phosphatidic acid (homo sapiens, C16:0, C18:2)

304563
type: Reaction
reactant: 025323
notes: GENE_ASSOCIATION: Pip5k1a.1 or Pip5k2c.1 or Pip5k3.1 or Pip5k1b.1 or Pip5k2b.2 or Pip5k1c.1 or Pip5k2a.1 or Pip5k3.2 or Pip5k3.3 or Pip5k2b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
product: 025360
product: 025335
product: 025348
kinetic law: 025372
reversible: false
reactant: 025311
name: phosphatidylinositol 4-phosphate 5-kinase (C16:0,C16:0)

025323
type: SpeciesReference
stoichiometry: 1.0
species: 303032

025360
type: SpeciesReference
stoichiometry: 1.0
species: 303011

025335
type: SpeciesReference
stoichiometry: 1.0
species: 302549

025348
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309191
type: LocalParameter
units: 006281
value: 0.0

309189
type: LocalParameter
units: 006281
value: 0.0

309187
type: LocalParameter
units: 006281
value: 1000.0

309185
type: LocalParameter
units: 006281
value: 0.0

025311
type: SpeciesReference
stoichiometry: 1.0
species: 302589

304760
type: Reaction
product: 029740
fast: false
product: 029716
reactant: 029704
product: 029728
kinetic law: 029753
name: pyridoxine kinase
reactant: 029692
notes: GENE_ASSOCIATION: PdxK.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false

029740
type: SpeciesReference
stoichiometry: 1.0
species: 303095

029716
type: SpeciesReference
stoichiometry: 1.0
species: 302549

029704
type: SpeciesReference
stoichiometry: 1.0
species: 303170

029728
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309719
type: LocalParameter
units: 006281
value: 0.0

309717
type: LocalParameter
units: 006281
value: 0.0

309715
type: LocalParameter
units: 006281
value: 1000.0

309713
type: LocalParameter
units: 006281
value: 0.0

029692
type: SpeciesReference
stoichiometry: 1.0
species: 302589

303545
type: Reaction
kinetic law: 006850
reactant: 006838
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Dehydroascorbate exchange

305144
type: LocalParameter
units: 006281
value: 0.0

305141
type: LocalParameter
units: 006281
value: 0.0

305138
type: LocalParameter
units: 006281
value: 0.0

305135
type: LocalParameter
units: 006281
value: -0.1111

006838
type: SpeciesReference
stoichiometry: 1.0
species: 303320

303995
type: Reaction
product: 013430
product: 013406
fast: false
reactant: 013382
reactant: 013394
name: choline phosphotransferase (C18:2, C16:0)
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013418
reversible: false
kinetic law: 013442

013430
type: SpeciesReference
stoichiometry: 1.0
species: 303089

013406
type: SpeciesReference
stoichiometry: 1.0
species: 302651

013382
type: SpeciesReference
stoichiometry: 1.0
species: 302615

013394
type: SpeciesReference
stoichiometry: 1.0
species: 302690

013418
type: SpeciesReference
stoichiometry: 1.0
species: 302819

306941
type: LocalParameter
units: 006281
value: 0.0

306938
type: LocalParameter
units: 006281
value: 0.0

306935
type: LocalParameter
units: 006281
value: 1000.0

306932
type: LocalParameter
units: 006281
value: 0.0

304359
type: Reaction
kinetic law: 021148
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 021088
reactant: 021064
product: 021124
reactant: 021076
fast: false
product: 021136
product: 021100
reversible: false
name: metanephrine secretion via secretory vesicle (ATP driven)
product: 021112

308403
type: LocalParameter
units: 006281
value: 0.0

308400
type: LocalParameter
units: 006281
value: 0.0

308397
type: LocalParameter
units: 006281
value: 1000.0

308394
type: LocalParameter
units: 006281
value: 0.0

021088
type: SpeciesReference
stoichiometry: 3.0
species: 302903

302903
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Metanephrine

021064
type: SpeciesReference
stoichiometry: 2.0
species: 302589

021124
type: SpeciesReference
stoichiometry: 2.0
species: 303131

021076
type: SpeciesReference
stoichiometry: 2.0
species: 302822

021136
type: SpeciesReference
stoichiometry: 3.0
species: 303410

021100
type: SpeciesReference
stoichiometry: 2.0
species: 302549

021112
type: SpeciesReference
stoichiometry: 2.0
species: 302819

304287
type: Reaction
kinetic law: 019782
product: 019770
reactant: 019758
notes: GENE_ASSOCIATION: Slc29a2.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Hypoxanthine transport

308115
type: LocalParameter
units: 006281
value: 0.0

308112
type: LocalParameter
units: 006281
value: 0.0

308109
type: LocalParameter
units: 006281
value: 1000.0

308106
type: LocalParameter
units: 006281
value: -1000.0

019770
type: SpeciesReference
stoichiometry: 1.0
species: 302840

019758
type: SpeciesReference
stoichiometry: 1.0
species: 303380

303518
type: Reaction
kinetic law: 006631
reactant: 006619
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Ascorbate exchange

305036
type: LocalParameter
units: 006281
value: 0.0

305033
type: LocalParameter
units: 006281
value: 0.0

305030
type: LocalParameter
units: 006281
value: 0.1111

305027
type: LocalParameter
units: 006281
value: 0.0

006619
type: SpeciesReference
stoichiometry: 1.0
species: 303293

304766
type: Reaction
reversible: false
product: 029838
product: 029826
fast: false
reactant: 029802
notes: GENE_ASSOCIATION: PdxP.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 029814
name: Pyridoxal 5-phosphate phosphatase
kinetic law: 029851

029838
type: SpeciesReference
stoichiometry: 1.0
species: 303164

029826
type: SpeciesReference
stoichiometry: 1.0
species: 303131

029802
type: SpeciesReference
stoichiometry: 1.0
species: 302822

029814
type: SpeciesReference
stoichiometry: 1.0
species: 303167

309735
type: LocalParameter
units: 006281
value: 0.0

309733
type: LocalParameter
units: 006281
value: 0.0

309731
type: LocalParameter
units: 006281
value: 1000.0

309729
type: LocalParameter
units: 006281
value: 0.0

304506
type: Reaction
reactant: 024163
name: 6-phosphogluconolactonase
reversible: false
fast: false
product: 024175
kinetic law: 024200
notes: GENE_ASSOCIATION: Pgls.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
reactant: 024151
product: 024187

024163
type: SpeciesReference
stoichiometry: 1.0
species: 302822

024175
type: SpeciesReference
stoichiometry: 1.0
species: 302514

308991
type: LocalParameter
units: 006281
value: 0.0

308988
type: LocalParameter
units: 006281
value: 0.0

308985
type: LocalParameter
units: 006281
value: 1000.0

308982
type: LocalParameter
units: 006281
value: 0.0

024151
type: SpeciesReference
stoichiometry: 1.0
species: 302517

024187
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304739
type: Reaction
kinetic law: 029283
fast: false
reactant: 029235
product: 029271
reversible: true
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: Purine Catabolism EC Number: Confidence Level: AUTHORS:
reactant: 029247
name: purine-nucleoside phosphorylase (Guanosine)
product: 029259

309663
type: LocalParameter
units: 006281
value: 0.0

309661
type: LocalParameter
units: 006281
value: 0.0

309659
type: LocalParameter
units: 006281
value: 1000.0

309657
type: LocalParameter
units: 006281
value: -1000.0

029235
type: SpeciesReference
stoichiometry: 1.0
species: 302801

029271
type: SpeciesReference
stoichiometry: 1.0
species: 303176

029247
type: SpeciesReference
stoichiometry: 1.0
species: 303131

029259
type: SpeciesReference
stoichiometry: 1.0
species: 302813

304497
type: Reaction
reactant: 023982
product: 024018
fast: false
name: 6-phosphofructo-2-kinase
product: 024030
notes: GENE_ASSOCIATION: Pfkfb1.1 or Pfkfb4.1 or Pfkfb3.1 or Pfkfb2.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
kinetic law: 024042
reactant: 023994
product: 024006

023982
type: SpeciesReference
stoichiometry: 1.0
species: 302589

024018
type: SpeciesReference
stoichiometry: 1.0
species: 302723

024030
type: SpeciesReference
stoichiometry: 1.0
species: 302819

308955
type: LocalParameter
units: 006281
value: 0.0

308952
type: LocalParameter
units: 006281
value: 0.0

308949
type: LocalParameter
units: 006281
value: 1000.0

308946
type: LocalParameter
units: 006281
value: 0.0

023994
type: SpeciesReference
stoichiometry: 1.0
species: 302726

024006
type: SpeciesReference
stoichiometry: 1.0
species: 302549

304694
type: Reaction
reactant: 028352
product: 028401
fast: false
name: purine-nucleoside phosphorylase
product: 028377
reactant: 028365
product: 028389
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
reversible: true
kinetic law: 028413

028352
type: SpeciesReference
stoichiometry: 1.0
species: 303131

028401
type: SpeciesReference
stoichiometry: 1.0
species: 303176

028377
type: SpeciesReference
stoichiometry: 1.0
species: 302819

028365
type: SpeciesReference
stoichiometry: 1.0
species: 303185

028389
type: SpeciesReference
stoichiometry: 1.0
species: 302945

309543
type: LocalParameter
units: 006281
value: 0.0

309541
type: LocalParameter
units: 006281
value: 0.0

309539
type: LocalParameter
units: 006281
value: 1000.0

309537
type: LocalParameter
units: 006281
value: -1000.0

303683
type: Reaction
kinetic law: 007964
reactant: 007952
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Pyridoxine exchange

305693
type: LocalParameter
units: 006281
value: 0.0

305690
type: LocalParameter
units: 006281
value: 0.0

305687
type: LocalParameter
units: 006281
value: 2.55E-4

305684
type: LocalParameter
units: 006281
value: -1.28E-4

007952
type: SpeciesReference
stoichiometry: 1.0
species: 303458

304671
type: Reaction
fast: false
reactant: 027812
reversible: false
name: phospholipase A2 (C16:0,C16:0)
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027800
product: 027824
product: 027849
product: 027836
kinetic law: 027862

027812
type: SpeciesReference
stoichiometry: 1.0
species: 303074

027800
type: SpeciesReference
stoichiometry: 1.0
species: 302822

027824
type: SpeciesReference
stoichiometry: 1.0
species: 302819

027849
type: SpeciesReference
stoichiometry: 1.0
species: 302882

027836
type: SpeciesReference
stoichiometry: 1.0
species: 302834

309479
type: LocalParameter
units: 006281
value: 0.0

309477
type: LocalParameter
units: 006281
value: 0.0

309475
type: LocalParameter
units: 006281
value: 1000.0

309473
type: LocalParameter
units: 006281
value: 0.0

304185
type: Reaction
fast: false
reactant: 017425
product: 017473
notes: GENE_ASSOCIATION: Gclm.1 and Gclc.1 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 017461
product: 017485
kinetic law: 017497
name: gamma-glutamylcysteine synthetase
reactant: 017437
reactant: 017413
product: 017449

017425
type: SpeciesReference
stoichiometry: 1.0
species: 302672

017473
type: SpeciesReference
stoichiometry: 1.0
species: 302819

017461
type: SpeciesReference
stoichiometry: 1.0
species: 302786

017485
type: SpeciesReference
stoichiometry: 1.0
species: 303131

307707
type: LocalParameter
units: 006281
value: 0.0

307704
type: LocalParameter
units: 006281
value: 0.0

307701
type: LocalParameter
units: 006281
value: 1000.0

307698
type: LocalParameter
units: 006281
value: 0.0

017437
type: SpeciesReference
stoichiometry: 1.0
species: 302783

017413
type: SpeciesReference
stoichiometry: 1.0
species: 302589

017449
type: SpeciesReference
stoichiometry: 1.0
species: 302549

303902
type: Reaction
product: 011251
notes: GENE_ASSOCIATION: SUBSYSTEM: Methionine Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
name: Band membrane protein-methyltransferase
reactant: 011203
reactant: 011215
kinetic law: 011264
product: 011227
reversible: true
product: 011239

011251
type: SpeciesReference
stoichiometry: 1.0
species: 302819

011203
type: SpeciesReference
stoichiometry: 1.0
species: 302572

011215
type: SpeciesReference
stoichiometry: 1.0
species: 302591

306569
type: LocalParameter
units: 006281
value: 0.0

306566
type: LocalParameter
units: 006281
value: 0.0

306563
type: LocalParameter
units: 006281
value: 1000.0

306560
type: LocalParameter
units: 006281
value: -1000.0

011227
type: SpeciesReference
stoichiometry: 1.0
species: 302556

011239
type: SpeciesReference
stoichiometry: 1.0
species: 302594

303689
type: Reaction
kinetic law: 008013
reactant: 008001
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Riboflavin exchange

305717
type: LocalParameter
units: 006281
value: 0.0

305714
type: LocalParameter
units: 006281
value: 0.0

305711
type: LocalParameter
units: 006281
value: 10.0

305708
type: LocalParameter
units: 006281
value: -10.0

008001
type: SpeciesReference
stoichiometry: 1.0
species: 303464

304709
type: Reaction
name: phosphatidic acid phosphatase (C18:1,C18:1)
reversible: false
reactant: 028666
kinetic law: 028714
product: 028702
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reactant: 028678
fast: false
product: 028690

028666
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309583
type: LocalParameter
units: 006281
value: 0.0

309581
type: LocalParameter
units: 006281
value: 0.0

309579
type: LocalParameter
units: 006281
value: 1000.0

309577
type: LocalParameter
units: 006281
value: 0.0

028702
type: SpeciesReference
stoichiometry: 1.0
species: 303131

028678
type: SpeciesReference
stoichiometry: 1.0
species: 302999

028690
type: SpeciesReference
stoichiometry: 1.0
species: 302684

304404
type: Reaction
kinetic law: 022041
product: 022029
reactant: 022017
notes: GENE_ASSOCIATION: Slc5a3.1-e or Slc5a1.1-e or Slc5a5.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sodium transport (uniport)

308583
type: LocalParameter
units: 006281
value: 0.0

308580
type: LocalParameter
units: 006281
value: 0.0

308577
type: LocalParameter
units: 006281
value: 1000.0

308574
type: LocalParameter
units: 006281
value: -1000.0

022029
type: SpeciesReference
stoichiometry: 1.0
species: 302927

022017
type: SpeciesReference
stoichiometry: 1.0
species: 303416

304070
type: Reaction
product: 015100
fast: false
reversible: true
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: Diacylglycerol phosphate kinase (homo sapiens, C18:2,C16:0)
product: 015113
product: 015125
reactant: 015088
kinetic law: 015137
reactant: 015076

015100
type: SpeciesReference
stoichiometry: 1.0
species: 302549

015113
type: SpeciesReference
stoichiometry: 1.0
species: 302819

015125
type: SpeciesReference
stoichiometry: 1.0
species: 303005

015088
type: SpeciesReference
stoichiometry: 1.0
species: 302690

307239
type: LocalParameter
units: 006281
value: 0.0

307236
type: LocalParameter
units: 006281
value: 0.0

307233
type: LocalParameter
units: 006281
value: 1000.0

307230
type: LocalParameter
units: 006281
value: -1000.0

015076
type: SpeciesReference
stoichiometry: 1.0
species: 302589

304332
type: Reaction
product: 020616
reactant: 020580
product: 020604
notes: GENE_ASSOCIATION: Lgals13 or Pla2g4a.1 or Clc.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 020568
kinetic law: 020628
product: 020592
name: lysophospholipase (C18:1)
fast: false
reversible: false

020616
type: SpeciesReference
stoichiometry: 1.0
species: 302972

020580
type: SpeciesReference
stoichiometry: 1.0
species: 302885

020604
type: SpeciesReference
stoichiometry: 1.0
species: 302819

020568
type: SpeciesReference
stoichiometry: 1.0
species: 302822

308295
type: LocalParameter
units: 006281
value: 0.0

308292
type: LocalParameter
units: 006281
value: 0.0

308289
type: LocalParameter
units: 006281
value: 1000.0

308286
type: LocalParameter
units: 006281
value: 0.0

020592
type: SpeciesReference
stoichiometry: 1.0
species: 302753

304811
type: Reaction
notes: GENE_ASSOCIATION: Srm.1 SUBSYSTEM: Urea cycle/amino group metabolism EC Number: Confidence Level: AUTHORS:
product: 030816
reactant: 030780
fast: false
kinetic law: 030828
product: 030804
reversible: false
name: spermidine synthase
product: 030792
reactant: 030768

030816
type: SpeciesReference
stoichiometry: 1.0
species: 303197

030780
type: SpeciesReference
stoichiometry: 1.0
species: 303155

309855
type: LocalParameter
units: 006281
value: 0.0

309853
type: LocalParameter
units: 006281
value: 0.0

309851
type: LocalParameter
units: 006281
value: 1000.0

309849
type: LocalParameter
units: 006281
value: 0.0

030804
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030792
type: SpeciesReference
stoichiometry: 1.0
species: 302508

030768
type: SpeciesReference
stoichiometry: 1.0
species: 302575

303836
type: Reaction
kinetic law: 009920
product: 009908
reactant: 009896
notes: GENE_ASSOCIATION: Slc29a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: adenosine facilated transport in cytosol

306305
type: LocalParameter
units: 006281
value: 0.0

306302
type: LocalParameter
units: 006281
value: 0.0

306299
type: LocalParameter
units: 006281
value: 1000.0

306296
type: LocalParameter
units: 006281
value: -1000.0

009908
type: SpeciesReference
stoichiometry: 1.0
species: 302547

009896
type: SpeciesReference
stoichiometry: 1.0
species: 303281

303281
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Adenosine

304515
type: Reaction
reversible: true
reactant: 024285
product: 024321
kinetic law: 024333
notes: GENE_ASSOCIATION: Got1.1 SUBSYSTEM: Phenylalanine metabolism EC Number: Confidence Level: AUTHORS:
reactant: 024297
fast: false
name: phenylalanine transaminase
product: 024309

024285
type: SpeciesReference
stoichiometry: 1.0
species: 302558

024321
type: SpeciesReference
stoichiometry: 1.0
species: 303128

303128
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Phenylpyruvate

309027
type: LocalParameter
units: 006281
value: 0.0

309024
type: LocalParameter
units: 006281
value: 0.0

309021
type: LocalParameter
units: 006281
value: 1000.0

309018
type: LocalParameter
units: 006281
value: -1000.0

024297
type: SpeciesReference
stoichiometry: 1.0
species: 303122

024309
type: SpeciesReference
stoichiometry: 1.0
species: 302783

303809
type: Reaction
kinetic law: 009417
product: 009405
product: 009393
reactant: 009381
notes: GENE_ASSOCIATION: Nans.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: N-Acetylneuraminate lyase (reversible)

306197
type: LocalParameter
units: 006281
value: 0.0

306194
type: LocalParameter
units: 006281
value: 0.0

306191
type: LocalParameter
units: 006281
value: 1000.0

306188
type: LocalParameter
units: 006281
value: -1000.0

009405
type: SpeciesReference
stoichiometry: 1.0
species: 303173

009393
type: SpeciesReference
stoichiometry: 1.0
species: 302532

009381
type: SpeciesReference
stoichiometry: 1.0
species: 302538

304076
type: Reaction
reversible: true
product: 015246
fast: false
reactant: 015234
kinetic law: 015271
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
name: dehydro-L-gulonate decarboxylase
reactant: 015222
product: 015258

015246
type: SpeciesReference
stoichiometry: 1.0
species: 302657

015234
type: SpeciesReference
stoichiometry: 1.0
species: 302819

307263
type: LocalParameter
units: 006281
value: 0.0

307260
type: LocalParameter
units: 006281
value: 0.0

307257
type: LocalParameter
units: 006281
value: 1000.0

307254
type: LocalParameter
units: 006281
value: -1000.0

015222
type: SpeciesReference
stoichiometry: 1.0
species: 302487

015258
type: SpeciesReference
stoichiometry: 1.0
species: 303254

304542
type: Reaction
product: 024829
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C16:0, C16:0)
kinetic law: 024865
product: 024853
reactant: 024805
reactant: 024817
fast: false
product: 024841

024829
type: SpeciesReference
stoichiometry: 1.0
species: 302675

309134
type: LocalParameter
units: 006281
value: 0.0

309131
type: LocalParameter
units: 006281
value: 0.0

309128
type: LocalParameter
units: 006281
value: 1000.0

309125
type: LocalParameter
units: 006281
value: 0.0

024853
type: SpeciesReference
stoichiometry: 1.0
species: 302915

024805
type: SpeciesReference
stoichiometry: 1.0
species: 302822

024817
type: SpeciesReference
stoichiometry: 1.0
species: 303011

024841
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303524
type: Reaction
kinetic law: 006679
reactant: 006667
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Calcium exchange

305060
type: LocalParameter
units: 006281
value: 0.0

305057
type: LocalParameter
units: 006281
value: 0.0

305054
type: LocalParameter
units: 006281
value: 10.0

305051
type: LocalParameter
units: 006281
value: -10.0

006667
type: SpeciesReference
stoichiometry: 1.0
species: 303299

303287
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: L-Alanine

303701
type: Reaction
kinetic law: 008111
reactant: 008098
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Thiamin monophosphate exchange

305765
type: LocalParameter
units: 006281
value: 0.0

305762
type: LocalParameter
units: 006281
value: 0.0

305759
type: LocalParameter
units: 006281
value: 6.0E-5

305756
type: LocalParameter
units: 006281
value: 0.0

008098
type: SpeciesReference
stoichiometry: 1.0
species: 303476

303974
type: Reaction
product: 012921
reactant: 012885
name: phosphatidate cytidylyltransferase (C18:2,C16:0)
fast: false
reversible: false
product: 012909
kinetic law: 012933
reactant: 012897
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 012873

012921
type: SpeciesReference
stoichiometry: 1.0
species: 303143

012885
type: SpeciesReference
stoichiometry: 1.0
species: 302819

012909
type: SpeciesReference
stoichiometry: 1.0
species: 302633

306857
type: LocalParameter
units: 006281
value: 0.0

306854
type: LocalParameter
units: 006281
value: 0.0

306851
type: LocalParameter
units: 006281
value: 1000.0

306848
type: LocalParameter
units: 006281
value: 0.0

012897
type: SpeciesReference
stoichiometry: 1.0
species: 303005

012873
type: SpeciesReference
stoichiometry: 1.0
species: 302669

304338
type: Reaction
kinetic law: 020749
product: 020737
reactant: 020725
reactant: 020713
notes: GENE_ASSOCIATION: Lta4h.1 SUBSYSTEM: Eicosanoid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Leukotriene A-4 hydrolase

308319
type: LocalParameter
units: 006281
value: 0.0

308316
type: LocalParameter
units: 006281
value: 0.0

308313
type: LocalParameter
units: 006281
value: 1000.0

308310
type: LocalParameter
units: 006281
value: 0.0

020737
type: SpeciesReference
stoichiometry: 1.0
species: 302867

020725
type: SpeciesReference
stoichiometry: 1.0
species: 302864

020713
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304049
type: Reaction
reversible: true
kinetic law: 014641
reactant: 014605
product: 014617
notes: GENE_ASSOCIATION: UmpK.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
product: 014629
reactant: 014593
name: cytidylate kinase (CMP)

307155
type: LocalParameter
units: 006281
value: 0.0

307152
type: LocalParameter
units: 006281
value: 0.0

307149
type: LocalParameter
units: 006281
value: 1000.0

307146
type: LocalParameter
units: 006281
value: -1000.0

014605
type: SpeciesReference
stoichiometry: 1.0
species: 302651

014617
type: SpeciesReference
stoichiometry: 1.0
species: 302549

014629
type: SpeciesReference
stoichiometry: 1.0
species: 302612

014593
type: SpeciesReference
stoichiometry: 1.0
species: 302589

304745
type: Reaction
product: 029415
notes: GENE_ASSOCIATION: PnpO.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
product: 029403
reactant: 029355
reactant: 029379
reactant: 029367
kinetic law: 029427
reversible: false
product: 029391
name: pyridoxamine 5'-phosphate oxidase
fast: false

029415
type: SpeciesReference
stoichiometry: 1.0
species: 303167

029403
type: SpeciesReference
stoichiometry: 1.0
species: 302948

029355
type: SpeciesReference
stoichiometry: 1.0
species: 302822

029379
type: SpeciesReference
stoichiometry: 1.0
species: 303158

029367
type: SpeciesReference
stoichiometry: 1.0
species: 302966

309679
type: LocalParameter
units: 006281
value: 0.0

309677
type: LocalParameter
units: 006281
value: 0.0

309675
type: LocalParameter
units: 006281
value: 1000.0

309673
type: LocalParameter
units: 006281
value: 0.0

029391
type: SpeciesReference
stoichiometry: 1.0
species: 302825

304230
type: Reaction
product: 018563
kinetic law: 018588
name: glutathione peridoxase
reversible: false
fast: false
reactant: 018551
product: 018576
reactant: 018539
notes: GENE_ASSOCIATION: Prdx2.3 or Prdx1.1 or Prdx1.2 or Gpx1.2 or Prdx1.3 or Gpx1.1 or Gpx4.1 or Prdx2.1 or Prdx2.2 SUBSYSTEM: Glutathione Metabolism EC Number: Confidence Level: AUTHORS:

018563
type: SpeciesReference
stoichiometry: 1.0
species: 302804

307887
type: LocalParameter
units: 006281
value: 0.0

307884
type: LocalParameter
units: 006281
value: 0.0

307881
type: LocalParameter
units: 006281
value: 1000.0

307878
type: LocalParameter
units: 006281
value: 0.0

018551
type: SpeciesReference
stoichiometry: 1.0
species: 302825

018576
type: SpeciesReference
stoichiometry: 2.0
species: 302822

018539
type: SpeciesReference
stoichiometry: 2.0
species: 302807

303947
type: Reaction
product: 012245
reversible: true
kinetic law: 012282
reactant: 012221
reactant: 012233
product: 012258
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
product: 012270
name: phosphatidylinositol synthase (Homo sapiens, C18:1,C18:1)

012245
type: SpeciesReference
stoichiometry: 1.0
species: 302651

306749
type: LocalParameter
units: 006281
value: 0.0

306746
type: LocalParameter
units: 006281
value: 0.0

306743
type: LocalParameter
units: 006281
value: 1000.0

306740
type: LocalParameter
units: 006281
value: -1000.0

012221
type: SpeciesReference
stoichiometry: 1.0
species: 302627

302627
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C18:1, C18:1)

012233
type: SpeciesReference
stoichiometry: 1.0
species: 302849

012258
type: SpeciesReference
stoichiometry: 1.0
species: 302819

012270
type: SpeciesReference
stoichiometry: 1.0
species: 303062

304680
type: Reaction
reactant: 028024
product: 028061
reactant: 028037
product: 028049
product: 028073
name: phospholipase A2 (C18:1,C18:1)
kinetic law: 028085
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false

028024
type: SpeciesReference
stoichiometry: 1.0
species: 302822

028061
type: SpeciesReference
stoichiometry: 1.0
species: 302885

028037
type: SpeciesReference
stoichiometry: 1.0
species: 303083

028049
type: SpeciesReference
stoichiometry: 1.0
species: 302819

028073
type: SpeciesReference
stoichiometry: 1.0
species: 302972

309503
type: LocalParameter
units: 006281
value: 0.0

309501
type: LocalParameter
units: 006281
value: 0.0

309499
type: LocalParameter
units: 006281
value: 1000.0

309497
type: LocalParameter
units: 006281
value: 0.0

303488
type: Reaction
kinetic law: 006389
reactant: 006377
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 4-Pyridoxate exchange

304916
type: LocalParameter
units: 006281
value: 0.0

304913
type: LocalParameter
units: 006281
value: 0.0

304910
type: LocalParameter
units: 006281
value: 3.83E-4

304907
type: LocalParameter
units: 006281
value: 0.0

006377
type: SpeciesReference
stoichiometry: 1.0
species: 303263

304718
type: Reaction
kinetic law: 028894
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reactant: 028846
reversible: false
reactant: 028858
name: phosphatidic acid phosphatase (C18:2, C18:1)
product: 028870
fast: false
product: 028882

309607
type: LocalParameter
units: 006281
value: 0.0

309605
type: LocalParameter
units: 006281
value: 0.0

309603
type: LocalParameter
units: 006281
value: 1000.0

309601
type: LocalParameter
units: 006281
value: 0.0

028846
type: SpeciesReference
stoichiometry: 1.0
species: 302822

028858
type: SpeciesReference
stoichiometry: 1.0
species: 303008

028870
type: SpeciesReference
stoichiometry: 1.0
species: 302693

028882
type: SpeciesReference
stoichiometry: 1.0
species: 303131

304203
type: Reaction
product: 017959
reactant: 017899
product: 017935
reversible: false
notes: GENE_ASSOCIATION: Gmps.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
name: GMP synthase
reactant: 017875
product: 017911
fast: false
kinetic law: 017971
product: 017947
reactant: 017887
reactant: 017862
product: 017923

017959
type: SpeciesReference
stoichiometry: 1.0
species: 303143

017899
type: SpeciesReference
stoichiometry: 1.0
species: 303242

017935
type: SpeciesReference
stoichiometry: 1.0
species: 302798

017875
type: SpeciesReference
stoichiometry: 1.0
species: 302780

017911
type: SpeciesReference
stoichiometry: 1.0
species: 302578

307779
type: LocalParameter
units: 006281
value: 0.0

307776
type: LocalParameter
units: 006281
value: 0.0

307773
type: LocalParameter
units: 006281
value: 1000.0

307770
type: LocalParameter
units: 006281
value: 0.0

017947
type: SpeciesReference
stoichiometry: 2.0
species: 302819

017887
type: SpeciesReference
stoichiometry: 1.0
species: 302822

017862
type: SpeciesReference
stoichiometry: 1.0
species: 302589

017923
type: SpeciesReference
stoichiometry: 1.0
species: 302783

304476
type: Reaction
reversible: false
product: 023571
fast: false
name: oroatp
kinetic law: 023583
product: 023559
reactant: 023535
reactant: 023547
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:

023571
type: SpeciesReference
stoichiometry: 1.0
species: 302984

302984
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Orotate

308871
type: LocalParameter
units: 006281
value: 0.0

308868
type: LocalParameter
units: 006281
value: 0.0

308865
type: LocalParameter
units: 006281
value: 1000.0

308862
type: LocalParameter
units: 006281
value: 0.0

023559
type: SpeciesReference
stoichiometry: 1.0
species: 302819

023535
type: SpeciesReference
stoichiometry: 1.0
species: 303362

023547
type: SpeciesReference
stoichiometry: 1.0
species: 303440

303440
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Orotate

303707
type: Reaction
kinetic law: 008159
reactant: 008147
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Uridine exchange

305789
type: LocalParameter
units: 006281
value: 0.0

305786
type: LocalParameter
units: 006281
value: 0.0

305783
type: LocalParameter
units: 006281
value: 0.01

305780
type: LocalParameter
units: 006281
value: 0.0

008147
type: SpeciesReference
stoichiometry: 1.0
species: 303482

303635
type: Reaction
kinetic law: 007577
reactant: 007565
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Metanephrine exchange

305501
type: LocalParameter
units: 006281
value: 0.0

305498
type: LocalParameter
units: 006281
value: 0.0

305495
type: LocalParameter
units: 006281
value: 0.0378

305492
type: LocalParameter
units: 006281
value: 0.0

007565
type: SpeciesReference
stoichiometry: 1.0
species: 303410

303662
type: Reaction
kinetic law: 007795
reactant: 007783
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: octadecenoate (n-C18:1) exchange

305609
type: LocalParameter
units: 006281
value: 0.0

305606
type: LocalParameter
units: 006281
value: 0.0

305603
type: LocalParameter
units: 006281
value: 0.0

305600
type: LocalParameter
units: 006281
value: -0.006

007783
type: SpeciesReference
stoichiometry: 1.0
species: 303437

303872
type: Reaction
reactant: 010573
notes: GENE_ASSOCIATION: Slc7a3.1 or Slc38a4.1 or Slc38a1.1 or Slc7a1.1 or Slc6a14.1 or Slc38a2.1 or Slc7a2.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 010585
product: 010609
kinetic law: 010621
product: 010597
reversible: true
name: Alanine-Sodium symporter
fast: false

010573
type: SpeciesReference
stoichiometry: 1.0
species: 303287

010585
type: SpeciesReference
stoichiometry: 1.0
species: 303416

010609
type: SpeciesReference
stoichiometry: 1.0
species: 302927

306449
type: LocalParameter
units: 006281
value: 0.0

306446
type: LocalParameter
units: 006281
value: 0.0

306443
type: LocalParameter
units: 006281
value: 1000.0

306440
type: LocalParameter
units: 006281
value: -1000.0

010597
type: SpeciesReference
stoichiometry: 1.0
species: 302561

304449
type: Reaction
product: 022967
reactant: 022955
reactant: 022942
notes: GENE_ASSOCIATION: Nt5C.1 SUBSYSTEM: NAD Metabolism EC Number: Confidence Level: AUTHORS:
name: 5'-nucleotidase (dTMP)
product: 022980
kinetic law: 022992
fast: false
reversible: false

022967
type: SpeciesReference
stoichiometry: 1.0
species: 303131

022955
type: SpeciesReference
stoichiometry: 1.0
species: 302957

022942
type: SpeciesReference
stoichiometry: 1.0
species: 302822

022980
type: SpeciesReference
stoichiometry: 1.0
species: 303185

308763
type: LocalParameter
units: 006281
value: 0.0

308760
type: LocalParameter
units: 006281
value: 0.0

308757
type: LocalParameter
units: 006281
value: 1000.0

308754
type: LocalParameter
units: 006281
value: 0.0

304209
type: Reaction
product: 018080
name: glycerol-3-phosphate acyltransferase (C16:0)
fast: false
reversible: false
reactant: 018056
reactant: 018068
notes: GENE_ASSOCIATION: Gpam.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
product: 018092
kinetic law: 018104

018080
type: SpeciesReference
stoichiometry: 1.0
species: 302564

018056
type: SpeciesReference
stoichiometry: 1.0
species: 302795

018068
type: SpeciesReference
stoichiometry: 1.0
species: 303134

018092
type: SpeciesReference
stoichiometry: 1.0
species: 302660

307803
type: LocalParameter
units: 006281
value: 0.0

307800
type: LocalParameter
units: 006281
value: 0.0

307797
type: LocalParameter
units: 006281
value: 1000.0

307794
type: LocalParameter
units: 006281
value: 0.0

304164
type: Reaction
kinetic law: 017015
product: 017002
reactant: 016990
notes: GENE_ASSOCIATION: Slc2a4.1-e or Slc2a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: glucosamine transport (uniport)

307623
type: LocalParameter
units: 006281
value: 0.0

307620
type: LocalParameter
units: 006281
value: 0.0

307617
type: LocalParameter
units: 006281
value: 1000.0

307614
type: LocalParameter
units: 006281
value: -1000.0

017002
type: SpeciesReference
stoichiometry: 1.0
species: 302767

016990
type: SpeciesReference
stoichiometry: 1.0
species: 303341

304883
type: Reaction
product: 032216
kinetic law: 032240
reactant: 032191
reversible: true
reactant: 032204
reactant: 032179
product: 032228
fast: false
name: xylulose reductase
notes: GENE_ASSOCIATION: Dcxr.1 SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:

032216
type: SpeciesReference
stoichiometry: 1.0
species: 302939

310047
type: LocalParameter
units: 006281
value: 0.0

310045
type: LocalParameter
units: 006281
value: 0.0

310043
type: LocalParameter
units: 006281
value: 1000.0

310041
type: LocalParameter
units: 006281
value: -1000.0

032191
type: SpeciesReference
stoichiometry: 1.0
species: 302942

032204
type: SpeciesReference
stoichiometry: 1.0
species: 303254

032179
type: SpeciesReference
stoichiometry: 1.0
species: 302819

032228
type: SpeciesReference
stoichiometry: 1.0
species: 303248

304659
type: Reaction
reactant: 027560
fast: false
product: 027584
kinetic law: 027608
reactant: 027548
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 027572
name: phosphatidylinositol phospholipase C (C18:1,C18:2)
product: 027596

027560
type: SpeciesReference
stoichiometry: 1.0
species: 303065

027584
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309447
type: LocalParameter
units: 006281
value: 0.0

309445
type: LocalParameter
units: 006281
value: 0.0

309443
type: LocalParameter
units: 006281
value: 1000.0

309441
type: LocalParameter
units: 006281
value: 0.0

027548
type: SpeciesReference
stoichiometry: 1.0
species: 302822

027572
type: SpeciesReference
stoichiometry: 1.0
species: 302687

027596
type: SpeciesReference
stoichiometry: 1.0
species: 302921

304856
type: Reaction
reversible: false
name: UDPglucuronate uridine-diphosphohydrolase
product: 031709
product: 031697
fast: false
reactant: 031673
reactant: 031661
product: 031685
kinetic law: 031721
notes: GENE_ASSOCIATION: SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:

031709
type: SpeciesReference
stoichiometry: 1.0
species: 303215

031697
type: SpeciesReference
stoichiometry: 1.0
species: 302819

031673
type: SpeciesReference
stoichiometry: 1.0
species: 303224

031661
type: SpeciesReference
stoichiometry: 1.0
species: 302822

031685
type: SpeciesReference
stoichiometry: 1.0
species: 302778

309975
type: LocalParameter
units: 006281
value: 0.0

309973
type: LocalParameter
units: 006281
value: 0.0

309971
type: LocalParameter
units: 006281
value: 1000.0

309969
type: LocalParameter
units: 006281
value: 0.0

302731
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: D-Fructose 1,6-bisphosphate

303845
type: Reaction
reversible: false
product: 010066
product: 010054
notes: GENE_ASSOCIATION: Cgi-14.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 010078
reactant: 010029
fast: false
name: N-acetylglucosamine-6-phosphate deacetylase
reactant: 010042

010066
type: SpeciesReference
stoichiometry: 1.0
species: 302769

010054
type: SpeciesReference
stoichiometry: 1.0
species: 302520

306341
type: LocalParameter
units: 006281
value: 0.0

306338
type: LocalParameter
units: 006281
value: 0.0

306335
type: LocalParameter
units: 006281
value: 1000.0

306332
type: LocalParameter
units: 006281
value: 0.0

010029
type: SpeciesReference
stoichiometry: 1.0
species: 302529

010042
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304137
type: Reaction
kinetic law: 016479
product: 016467
reactant: 016455
reactant: 016443
notes: GENE_ASSOCIATION: Fh.1 SUBSYSTEM: Citric Acid Cycle EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: fumarase

307515
type: LocalParameter
units: 006281
value: 0.0

307512
type: LocalParameter
units: 006281
value: 0.0

307509
type: LocalParameter
units: 006281
value: 1000.0

307506
type: LocalParameter
units: 006281
value: -1000.0

016467
type: SpeciesReference
stoichiometry: 1.0
species: 302891

016455
type: SpeciesReference
stoichiometry: 1.0
species: 302822

016443
type: SpeciesReference
stoichiometry: 1.0
species: 302745

302745
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Fumarate

304374
type: Reaction
reactant: 021400
product: 021412
reactant: 021388
name: inositol-1,4,5-trisphosphate 3-kinase
notes: GENE_ASSOCIATION: Itpkb.1 or Itpka.1 or Itpkc.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 021448
reversible: false
fast: false
product: 021436
product: 021424

021400
type: SpeciesReference
stoichiometry: 1.0
species: 302915

021412
type: SpeciesReference
stoichiometry: 1.0
species: 302549

021388
type: SpeciesReference
stoichiometry: 1.0
species: 302589

308463
type: LocalParameter
units: 006281
value: 0.0

308460
type: LocalParameter
units: 006281
value: 0.0

308457
type: LocalParameter
units: 006281
value: 1000.0

308454
type: LocalParameter
units: 006281
value: 0.0

021436
type: SpeciesReference
stoichiometry: 1.0
species: 302909

021424
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304551
type: Reaction
product: 025070
reactant: 025022
reactant: 025034
fast: false
kinetic law: 025082
name: phosphatidylinositol 4,5-bisphosphate phospholipase C (C18:1, C18:1)
product: 025058
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 025046

025070
type: SpeciesReference
stoichiometry: 1.0
species: 302915

025022
type: SpeciesReference
stoichiometry: 1.0
species: 302822

025034
type: SpeciesReference
stoichiometry: 1.0
species: 303020

309159
type: LocalParameter
units: 006281
value: 0.0

309157
type: LocalParameter
units: 006281
value: 0.0

309155
type: LocalParameter
units: 006281
value: 1000.0

309153
type: LocalParameter
units: 006281
value: 0.0

025058
type: SpeciesReference
stoichiometry: 1.0
species: 302819

025046
type: SpeciesReference
stoichiometry: 1.0
species: 302684

303533
type: Reaction
kinetic law: 006751
reactant: 006739
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Chloride exchange

305096
type: LocalParameter
units: 006281
value: 0.0

305093
type: LocalParameter
units: 006281
value: 0.0

305090
type: LocalParameter
units: 006281
value: 10.0

305087
type: LocalParameter
units: 006281
value: -10.0

006739
type: SpeciesReference
stoichiometry: 1.0
species: 303308

303560
type: Reaction
kinetic law: 006971
reactant: 006959
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Fumarate exchange

305201
type: LocalParameter
units: 006281
value: 0.0

305198
type: LocalParameter
units: 006281
value: 0.0

305195
type: LocalParameter
units: 006281
value: 0.5

305192
type: LocalParameter
units: 006281
value: -0.25

006959
type: SpeciesReference
stoichiometry: 1.0
species: 303335

303983
type: Reaction
fast: false
reactant: 013091
kinetic law: 013151
reactant: 013103
product: 013127
name: choline phosphotransferase (C16:0, C18:1)
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013139
product: 013115
reversible: false

013091
type: SpeciesReference
stoichiometry: 1.0
species: 302615

306893
type: LocalParameter
units: 006281
value: 0.0

306890
type: LocalParameter
units: 006281
value: 0.0

306887
type: LocalParameter
units: 006281
value: 1000.0

306884
type: LocalParameter
units: 006281
value: 0.0

013103
type: SpeciesReference
stoichiometry: 1.0
species: 302678

013127
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013139
type: SpeciesReference
stoichiometry: 1.0
species: 303077

013115
type: SpeciesReference
stoichiometry: 1.0
species: 302651

304347
type: Reaction
kinetic law: 020858
product: 020846
reactant: 020834
notes: GENE_ASSOCIATION: Slc2a1.1-e or Slc2a3.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: mannose transport (uniport)

308355
type: LocalParameter
units: 006281
value: 0.0

308352
type: LocalParameter
units: 006281
value: 0.0

308349
type: LocalParameter
units: 006281
value: 1000.0

308346
type: LocalParameter
units: 006281
value: -1000.0

020846
type: SpeciesReference
stoichiometry: 1.0
species: 302894

020834
type: SpeciesReference
stoichiometry: 1.0
species: 303407

304754
type: Reaction
fast: false
reactant: 029571
reactant: 029547
notes: GENE_ASSOCIATION: Aox1.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
product: 029595
reversible: false
kinetic law: 029608
product: 029583
name: pyridoxal dehydrogenase
reactant: 029559

029571
type: SpeciesReference
stoichiometry: 1.0
species: 303164

029547
type: SpeciesReference
stoichiometry: 1.0
species: 302822

029595
type: SpeciesReference
stoichiometry: 1.0
species: 302825

309703
type: LocalParameter
units: 006281
value: 0.0

309701
type: LocalParameter
units: 006281
value: 0.0

309699
type: LocalParameter
units: 006281
value: 1000.0

309697
type: LocalParameter
units: 006281
value: 0.0

029583
type: SpeciesReference
stoichiometry: 1.0
species: 302496

029559
type: SpeciesReference
stoichiometry: 1.0
species: 302966

303779
type: Reaction
kinetic law: 008776
fast: false
name: 2-keto-4-methylthiobutyrate transaminase
product: 008752
reactant: 008728
product: 008764
notes: GENE_ASSOCIATION: Tat.1 SUBSYSTEM: Methionine Salvage EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 008740

306077
type: LocalParameter
units: 006281
value: 0.0

306074
type: LocalParameter
units: 006281
value: 0.0

306071
type: LocalParameter
units: 006281
value: 1000.0

306068
type: LocalParameter
units: 006281
value: 0.0

008752
type: SpeciesReference
stoichiometry: 1.0
species: 302558

008728
type: SpeciesReference
stoichiometry: 1.0
species: 302478

008764
type: SpeciesReference
stoichiometry: 1.0
species: 302906

008740
type: SpeciesReference
stoichiometry: 1.0
species: 302783

304781
type: Reaction
reactant: 030105
reactant: 030129
kinetic law: 030189
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
product: 030153
reversible: false
product: 030141
product: 030177
product: 030165
fast: false
reactant: 030117
name: riboflavin transport (ATP dependent)

030105
type: SpeciesReference
stoichiometry: 1.0
species: 302589

030129
type: SpeciesReference
stoichiometry: 1.0
species: 303464

309775
type: LocalParameter
units: 006281
value: 0.0

309773
type: LocalParameter
units: 006281
value: 0.0

309771
type: LocalParameter
units: 006281
value: 1000.0

309769
type: LocalParameter
units: 006281
value: 0.0

030153
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030141
type: SpeciesReference
stoichiometry: 1.0
species: 302549

030177
type: SpeciesReference
stoichiometry: 1.0
species: 303182

030165
type: SpeciesReference
stoichiometry: 1.0
species: 303131

030117
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304055
type: Reaction
kinetic law: 014774
product: 014762
reactant: 014726
name: Diacylglycerol phosphate kinase (homo sapiens, C16:0, C16:0)
reversible: true
fast: false
product: 014738
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 014714
product: 014750

307179
type: LocalParameter
units: 006281
value: 0.0

307176
type: LocalParameter
units: 006281
value: 0.0

307173
type: LocalParameter
units: 006281
value: 1000.0

307170
type: LocalParameter
units: 006281
value: -1000.0

014762
type: SpeciesReference
stoichiometry: 1.0
species: 302990

014726
type: SpeciesReference
stoichiometry: 1.0
species: 302675

014738
type: SpeciesReference
stoichiometry: 1.0
species: 302549

014714
type: SpeciesReference
stoichiometry: 1.0
species: 302589

014750
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304521
type: Reaction
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C16:0)
kinetic law: 024429
product: 024417
fast: false
product: 024405
reactant: 024393
reactant: 024381

309051
type: LocalParameter
units: 006281
value: 0.0

309048
type: LocalParameter
units: 006281
value: 0.0

309045
type: LocalParameter
units: 006281
value: 1000.0

309042
type: LocalParameter
units: 006281
value: 0.0

024417
type: SpeciesReference
stoichiometry: 1.0
species: 303131

024405
type: SpeciesReference
stoichiometry: 1.0
species: 303032

024393
type: SpeciesReference
stoichiometry: 1.0
species: 303011

024381
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304485
type: Reaction
name: pyridoxine 5'-phosphate oxidase
reactant: 023717
fast: false
product: 023742
product: 023754
reversible: true
notes: GENE_ASSOCIATION: PnpO.1 SUBSYSTEM: Vitamin B6 Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 023766
reactant: 023729

023717
type: SpeciesReference
stoichiometry: 1.0
species: 302966

023742
type: SpeciesReference
stoichiometry: 1.0
species: 302825

023754
type: SpeciesReference
stoichiometry: 1.0
species: 303167

308907
type: LocalParameter
units: 006281
value: 0.0

308904
type: LocalParameter
units: 006281
value: 0.0

308901
type: LocalParameter
units: 006281
value: 1000.0

308898
type: LocalParameter
units: 006281
value: -1000.0

023729
type: SpeciesReference
stoichiometry: 1.0
species: 303095

303494
type: Reaction
kinetic law: 006437
reactant: 006425
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Acetate exchange

304940
type: LocalParameter
units: 006281
value: 0.0

304937
type: LocalParameter
units: 006281
value: 0.0

304934
type: LocalParameter
units: 006281
value: 3.74E-5

304931
type: LocalParameter
units: 006281
value: 0.0

006425
type: SpeciesReference
stoichiometry: 1.0
species: 303269

303989
type: Reaction
reversible: false
product: 013274
product: 013262
reactant: 013237
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 013298
reactant: 013249
name: choline phosphotransferase (C18:1, C18:1)
product: 013286
fast: false

013274
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013262
type: SpeciesReference
stoichiometry: 1.0
species: 302651

013237
type: SpeciesReference
stoichiometry: 1.0
species: 302615

306917
type: LocalParameter
units: 006281
value: 0.0

306914
type: LocalParameter
units: 006281
value: 0.0

306911
type: LocalParameter
units: 006281
value: 1000.0

306908
type: LocalParameter
units: 006281
value: 0.0

013249
type: SpeciesReference
stoichiometry: 1.0
species: 302684

013286
type: SpeciesReference
stoichiometry: 1.0
species: 303083

303671
type: Reaction
kinetic law: 007868
reactant: 007855
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Phosphate exchange

305645
type: LocalParameter
units: 006281
value: 0.0

305642
type: LocalParameter
units: 006281
value: 0.0

305639
type: LocalParameter
units: 006281
value: 0.0

305636
type: LocalParameter
units: 006281
value: -1.30470065185183

007855
type: SpeciesReference
stoichiometry: 1.0
species: 303446

303446
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: Phosphate

304028
type: Reaction
notes: GENE_ASSOCIATION: Pcyt1a.1 or Pcyt1b.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 014218
product: 014230
reactant: 014206
reactant: 014194
reversible: false
kinetic law: 014254
fast: false
product: 014242
name: choline phosphate cytididyltransferase

014218
type: SpeciesReference
stoichiometry: 1.0
species: 302819

014230
type: SpeciesReference
stoichiometry: 1.0
species: 302615

014206
type: SpeciesReference
stoichiometry: 1.0
species: 302669

014194
type: SpeciesReference
stoichiometry: 1.0
species: 302645

307071
type: LocalParameter
units: 006281
value: 0.0

307068
type: LocalParameter
units: 006281
value: 0.0

307065
type: LocalParameter
units: 006281
value: 1000.0

307062
type: LocalParameter
units: 006281
value: 0.0

014242
type: SpeciesReference
stoichiometry: 1.0
species: 303143

302969
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: Oxaloacetate

304173
type: Reaction
fast: false
kinetic law: 017208
reversible: true
notes: GENE_ASSOCIATION: Guk1.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 017172
name: guanylate kinase (GMP:ATP)
product: 017196
product: 017184
reactant: 017160

307659
type: LocalParameter
units: 006281
value: 0.0

307656
type: LocalParameter
units: 006281
value: 0.0

307653
type: LocalParameter
units: 006281
value: 1000.0

307650
type: LocalParameter
units: 006281
value: -1000.0

017172
type: SpeciesReference
stoichiometry: 1.0
species: 302798

017196
type: SpeciesReference
stoichiometry: 1.0
species: 302772

017184
type: SpeciesReference
stoichiometry: 1.0
species: 302549

017160
type: SpeciesReference
stoichiometry: 1.0
species: 302589

303677
type: Reaction
kinetic law: 007916
reactant: 007904
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Pyridoxamine exchange

305669
type: LocalParameter
units: 006281
value: 0.0

305666
type: LocalParameter
units: 006281
value: 0.0

305663
type: LocalParameter
units: 006281
value: 0.0

305660
type: LocalParameter
units: 006281
value: -1.0E-4

007904
type: SpeciesReference
stoichiometry: 1.0
species: 303452

304688
type: Reaction
reactant: 028243
name: phospholipase A2 (C18:2,C18:1)
kinetic law: 028304
reversible: false
product: 028267
product: 028291
fast: false
product: 028279
reactant: 028255
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:

028243
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309527
type: LocalParameter
units: 006281
value: 0.0

309525
type: LocalParameter
units: 006281
value: 0.0

309523
type: LocalParameter
units: 006281
value: 1000.0

309521
type: LocalParameter
units: 006281
value: 0.0

028267
type: SpeciesReference
stoichiometry: 1.0
species: 302819

028291
type: SpeciesReference
stoichiometry: 1.0
species: 302972

028279
type: SpeciesReference
stoichiometry: 1.0
species: 302888

028255
type: SpeciesReference
stoichiometry: 1.0
species: 303092

304638
type: Reaction
fast: false
product: 027066
reactant: 027054
product: 027090
reversible: false
name: phosphatidylinositol 4-kinase (C18:1,C18:2)
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027041
kinetic law: 027102
product: 027078

027066
type: SpeciesReference
stoichiometry: 1.0
species: 302549

027054
type: SpeciesReference
stoichiometry: 1.0
species: 303065

027090
type: SpeciesReference
stoichiometry: 1.0
species: 303044

027041
type: SpeciesReference
stoichiometry: 1.0
species: 302589

309391
type: LocalParameter
units: 006281
value: 0.0

309389
type: LocalParameter
units: 006281
value: 0.0

309387
type: LocalParameter
units: 006281
value: 1000.0

309385
type: LocalParameter
units: 006281
value: 0.0

027078
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304320
type: Reaction
name: carnitine O-palmitoyltransferase
reactant: 020350
product: 020374
notes: GENE_ASSOCIATION: Cpt1a.1 SUBSYSTEM: Carnitine shuttle EC Number: Confidence Level: AUTHORS:
reactant: 020338
kinetic law: 020386
product: 020362
fast: false
reversible: false

020350
type: SpeciesReference
stoichiometry: 1.0
species: 302876

020374
type: SpeciesReference
stoichiometry: 1.0
species: 302879

020338
type: SpeciesReference
stoichiometry: 1.0
species: 302666

308247
type: LocalParameter
units: 006281
value: 0.0

308244
type: LocalParameter
units: 006281
value: 0.0

308241
type: LocalParameter
units: 006281
value: 1000.0

308238
type: LocalParameter
units: 006281
value: 0.0

020362
type: SpeciesReference
stoichiometry: 1.0
species: 302660

304179
type: Reaction
reactant: 017256
reactant: 017268
product: 017328
reactant: 017280
product: 017292
kinetic law: 017340
fast: false
reversible: false
product: 017316
product: 017304
notes: GENE_ASSOCIATION: Glul.1 SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: AUTHORS:
name: glutamine synthetase

017256
type: SpeciesReference
stoichiometry: 1.0
species: 302589

017268
type: SpeciesReference
stoichiometry: 1.0
species: 302783

017328
type: SpeciesReference
stoichiometry: 1.0
species: 303131

017280
type: SpeciesReference
stoichiometry: 1.0
species: 302948

017292
type: SpeciesReference
stoichiometry: 1.0
species: 302549

307683
type: LocalParameter
units: 006281
value: 0.0

307680
type: LocalParameter
units: 006281
value: 0.0

307677
type: LocalParameter
units: 006281
value: 1000.0

307674
type: LocalParameter
units: 006281
value: 0.0

017316
type: SpeciesReference
stoichiometry: 1.0
species: 302819

017304
type: SpeciesReference
stoichiometry: 1.0
species: 302780

303824
type: Reaction
kinetic law: 009698
product: 009685
reactant: 009672
reactant: 009659
notes: GENE_ASSOCIATION: Ak1.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: adenylate kinase

306257
type: LocalParameter
units: 006281
value: 0.0

306254
type: LocalParameter
units: 006281
value: 0.0

306251
type: LocalParameter
units: 006281
value: 1000.0

306248
type: LocalParameter
units: 006281
value: -1000.0

009685
type: SpeciesReference
stoichiometry: 2.0
species: 302549

009672
type: SpeciesReference
stoichiometry: 1.0
species: 302589

009659
type: SpeciesReference
stoichiometry: 1.0
species: 302578

304091
type: Reaction
kinetic law: 015511
product: 015499
product: 015487
reactant: 015475
notes: GENE_ASSOCIATION: Bpgm.2 or Bpgm.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Diphosphoglyceromutase

307323
type: LocalParameter
units: 006281
value: 0.0

307320
type: LocalParameter
units: 006281
value: 0.0

307317
type: LocalParameter
units: 006281
value: 1000.0

307314
type: LocalParameter
units: 006281
value: -1000.0

015499
type: SpeciesReference
stoichiometry: 1.0
species: 302819

015487
type: SpeciesReference
stoichiometry: 1.0
species: 302475

015475
type: SpeciesReference
stoichiometry: 1.0
species: 302473

304064
type: Reaction
reactant: 014944
name: Diacylglycerol phosphate kinase (homo sapiens, C18:1,C18:1)
fast: false
kinetic law: 014992
product: 014980
reactant: 014931
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reversible: true
product: 014956
product: 014968

014944
type: SpeciesReference
stoichiometry: 1.0
species: 302684

307215
type: LocalParameter
units: 006281
value: 0.0

307212
type: LocalParameter
units: 006281
value: 0.0

307209
type: LocalParameter
units: 006281
value: 1000.0

307206
type: LocalParameter
units: 006281
value: -1000.0

014980
type: SpeciesReference
stoichiometry: 1.0
species: 302999

014931
type: SpeciesReference
stoichiometry: 1.0
species: 302589

014956
type: SpeciesReference
stoichiometry: 1.0
species: 302549

014968
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304530
type: Reaction
product: 024587
reactant: 024563
fast: false
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:1, C18:1)
kinetic law: 024612
reversible: false
product: 024600
reactant: 024575

024587
type: SpeciesReference
stoichiometry: 1.0
species: 303041

024563
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309087
type: LocalParameter
units: 006281
value: 0.0

309084
type: LocalParameter
units: 006281
value: 0.0

309081
type: LocalParameter
units: 006281
value: 1000.0

309078
type: LocalParameter
units: 006281
value: 0.0

024600
type: SpeciesReference
stoichiometry: 1.0
species: 303131

024575
type: SpeciesReference
stoichiometry: 1.0
species: 303020

303512
type: Reaction
kinetic law: 006582
reactant: 006570
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Alanine exchange

305012
type: LocalParameter
units: 006281
value: 0.0

305009
type: LocalParameter
units: 006281
value: 0.0

305006
type: LocalParameter
units: 006281
value: 0.08

305003
type: LocalParameter
units: 006281
value: 0.0

006570
type: SpeciesReference
stoichiometry: 1.0
species: 303287

303962
type: Reaction
product: 012620
reactant: 012608
reversible: false
reactant: 012596
name: phosphatidate cytidylyltransferase (C16:0, C18:1)
kinetic law: 012644
fast: false
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 012632
reactant: 012584

012620
type: SpeciesReference
stoichiometry: 1.0
species: 302621

012608
type: SpeciesReference
stoichiometry: 1.0
species: 302993

012596
type: SpeciesReference
stoichiometry: 1.0
species: 302819

306809
type: LocalParameter
units: 006281
value: 0.0

306806
type: LocalParameter
units: 006281
value: 0.0

306803
type: LocalParameter
units: 006281
value: 1000.0

306800
type: LocalParameter
units: 006281
value: 0.0

012632
type: SpeciesReference
stoichiometry: 1.0
species: 303143

012584
type: SpeciesReference
stoichiometry: 1.0
species: 302669

303266
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302472
name: 5-Amino-4-oxopentanoate

304326
type: Reaction
kinetic law: 020483
product: 020471
reactant: 020459
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Linoleic acid (n-C18:2) transport in via diffusion

308271
type: LocalParameter
units: 006281
value: 0.0

308268
type: LocalParameter
units: 006281
value: 0.0

308265
type: LocalParameter
units: 006281
value: 1000.0

308262
type: LocalParameter
units: 006281
value: -1000.0

020471
type: SpeciesReference
stoichiometry: 1.0
species: 302873

020459
type: SpeciesReference
stoichiometry: 1.0
species: 303401

304536
type: Reaction
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 024720
reactant: 024696
product: 024708
reactant: 024684
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C18:2, C16:0)
kinetic law: 024732
fast: false
reversible: false

024720
type: SpeciesReference
stoichiometry: 1.0
species: 303131

024696
type: SpeciesReference
stoichiometry: 1.0
species: 303026

024708
type: SpeciesReference
stoichiometry: 1.0
species: 303047

024684
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309110
type: LocalParameter
units: 006281
value: 0.0

309107
type: LocalParameter
units: 006281
value: 0.0

309104
type: LocalParameter
units: 006281
value: 1000.0

309101
type: LocalParameter
units: 006281
value: 0.0

304733
type: Reaction
kinetic law: 029162
product: 029150
reactant: 029138
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: puterscine transport (faciliated)

309647
type: LocalParameter
units: 006281
value: 0.0

309645
type: LocalParameter
units: 006281
value: 0.0

309643
type: LocalParameter
units: 006281
value: 1000.0

309641
type: LocalParameter
units: 006281
value: -1000.0

029150
type: SpeciesReference
stoichiometry: 1.0
species: 303155

029138
type: SpeciesReference
stoichiometry: 1.0
species: 303449

304491
type: Reaction
product: 023874
reactant: 023862
notes: GENE_ASSOCIATION: Pcyt2.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 023850
fast: false
name: phosphoethanolamine cytidyltransferase
kinetic law: 023898
product: 023886
reversible: false
reactant: 023838

023874
type: SpeciesReference
stoichiometry: 1.0
species: 302639

023862
type: SpeciesReference
stoichiometry: 1.0
species: 302819

023850
type: SpeciesReference
stoichiometry: 1.0
species: 302720

308931
type: LocalParameter
units: 006281
value: 0.0

308928
type: LocalParameter
units: 006281
value: 0.0

308925
type: LocalParameter
units: 006281
value: 1000.0

308922
type: LocalParameter
units: 006281
value: 0.0

023886
type: SpeciesReference
stoichiometry: 1.0
species: 303143

023838
type: SpeciesReference
stoichiometry: 1.0
species: 302669

303722
type: Reaction
kinetic law: 008280
reactant: 008268
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink for(c)

305849
type: LocalParameter
units: 006281
value: 0.0

305846
type: LocalParameter
units: 006281
value: 0.0

305843
type: LocalParameter
units: 006281
value: 10.0

305840
type: LocalParameter
units: 006281
value: -10.0

008268
type: SpeciesReference
stoichiometry: 1.0
species: 302739

304509
type: Reaction
kinetic law: 024236
product: 024224
reactant: 024212
notes: GENE_ASSOCIATION: Bpgm.1 or Bpgm.2 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: phosphoglycerate mutase

309003
type: LocalParameter
units: 006281
value: 0.0

309000
type: LocalParameter
units: 006281
value: 0.0

308997
type: LocalParameter
units: 006281
value: 1000.0

308994
type: LocalParameter
units: 006281
value: -1000.0

024224
type: SpeciesReference
stoichiometry: 1.0
species: 302493

024212
type: SpeciesReference
stoichiometry: 1.0
species: 302481

304706
type: Reaction
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reactant: 028606
kinetic law: 028654
reactant: 028618
product: 028642
fast: false
product: 028630
name: phosphatidic acid phosphatase (C16:0, C18:2)
reversible: false

028606
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309575
type: LocalParameter
units: 006281
value: 0.0

309573
type: LocalParameter
units: 006281
value: 0.0

309571
type: LocalParameter
units: 006281
value: 1000.0

309569
type: LocalParameter
units: 006281
value: 0.0

028618
type: SpeciesReference
stoichiometry: 1.0
species: 302996

028642
type: SpeciesReference
stoichiometry: 1.0
species: 303131

028630
type: SpeciesReference
stoichiometry: 1.0
species: 302681

304464
type: Reaction
kinetic law: 023304
product: 023292
reactant: 023280
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: fatty acid transport via diffusion

308823
type: LocalParameter
units: 006281
value: 0.0

308820
type: LocalParameter
units: 006281
value: 0.0

308817
type: LocalParameter
units: 006281
value: 1000.0

308814
type: LocalParameter
units: 006281
value: -1000.0

023292
type: SpeciesReference
stoichiometry: 1.0
species: 302972

023280
type: SpeciesReference
stoichiometry: 1.0
species: 303437

303968
type: Reaction
reactant: 012728
reversible: false
reactant: 012752
name: phosphatidate cytidylyltransferase (C18:1,C18:1)
reactant: 012740
fast: false
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 012765
kinetic law: 012789
product: 012777

012728
type: SpeciesReference
stoichiometry: 1.0
species: 302669

012752
type: SpeciesReference
stoichiometry: 1.0
species: 302999

012740
type: SpeciesReference
stoichiometry: 1.0
species: 302819

012765
type: SpeciesReference
stoichiometry: 1.0
species: 302627

306833
type: LocalParameter
units: 006281
value: 0.0

306830
type: LocalParameter
units: 006281
value: 0.0

306827
type: LocalParameter
units: 006281
value: 1000.0

306824
type: LocalParameter
units: 006281
value: 0.0

012777
type: SpeciesReference
stoichiometry: 1.0
species: 303143

303650
type: Reaction
kinetic law: 007698
reactant: 007686
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Ammonia exchange

305561
type: LocalParameter
units: 006281
value: 0.0

305558
type: LocalParameter
units: 006281
value: 0.0

305555
type: LocalParameter
units: 006281
value: 0.0341474000000002

305552
type: LocalParameter
units: 006281
value: -9.99999999999446E-4

007686
type: SpeciesReference
stoichiometry: 1.0
species: 303425

303860
type: Reaction
reactant: 010331
kinetic law: 010379
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C18:1,C18:2)
reactant: 010343
product: 010355
product: 010367
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false

010331
type: SpeciesReference
stoichiometry: 1.0
species: 302567

306401
type: LocalParameter
units: 006281
value: 0.0

306398
type: LocalParameter
units: 006281
value: 0.0

306395
type: LocalParameter
units: 006281
value: 1000.0

306392
type: LocalParameter
units: 006281
value: 0.0

010343
type: SpeciesReference
stoichiometry: 1.0
species: 302876

010355
type: SpeciesReference
stoichiometry: 1.0
species: 302660

010367
type: SpeciesReference
stoichiometry: 1.0
species: 303002

304224
type: Reaction
reversible: false
product: 018418
name: glutathione oxidoreductase
reactant: 018393
fast: false
product: 018405
reactant: 018369
notes: GENE_ASSOCIATION: Gsr.2 SUBSYSTEM: Glutamate metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 018431
reactant: 018381

018418
type: SpeciesReference
stoichiometry: 1.0
species: 302939

018393
type: SpeciesReference
stoichiometry: 1.0
species: 302942

018405
type: SpeciesReference
stoichiometry: 2.0
species: 302807

018369
type: SpeciesReference
stoichiometry: 1.0
species: 302804

307863
type: LocalParameter
units: 006281
value: 0.0

307860
type: LocalParameter
units: 006281
value: 0.0

307857
type: LocalParameter
units: 006281
value: 1000.0

307854
type: LocalParameter
units: 006281
value: 0.0

018381
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304152
type: Reaction
product: 016781
name: D-Galactose:NADP+ 1-oxidoreductase
product: 016769
fast: false
reactant: 016731
reactant: 016743
notes: GENE_ASSOCIATION: Akr1a1.2 or Akr1a1.1 or Akr1b1.1 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 016794
reversible: true
reactant: 016756

016781
type: SpeciesReference
stoichiometry: 1.0
species: 302939

016769
type: SpeciesReference
stoichiometry: 1.0
species: 302765

016731
type: SpeciesReference
stoichiometry: 1.0
species: 302759

016743
type: SpeciesReference
stoichiometry: 1.0
species: 302819

307575
type: LocalParameter
units: 006281
value: 0.0

307572
type: LocalParameter
units: 006281
value: 0.0

307569
type: LocalParameter
units: 006281
value: 1000.0

307566
type: LocalParameter
units: 006281
value: -1000.0

016756
type: SpeciesReference
stoichiometry: 1.0
species: 302942

304674
type: Reaction
reactant: 027888
name: phospholipase A2 (C16:0,C18:1)
reversible: false
reactant: 027875
fast: false
product: 027927
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
kinetic law: 027940
product: 027914
product: 027901

027888
type: SpeciesReference
stoichiometry: 1.0
species: 303077

027875
type: SpeciesReference
stoichiometry: 1.0
species: 302822

027927
type: SpeciesReference
stoichiometry: 1.0
species: 302972

309487
type: LocalParameter
units: 006281
value: 0.0

309485
type: LocalParameter
units: 006281
value: 0.0

309483
type: LocalParameter
units: 006281
value: 1000.0

309481
type: LocalParameter
units: 006281
value: 0.0

027914
type: SpeciesReference
stoichiometry: 1.0
species: 302882

027901
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304647
type: Reaction
product: 027295
name: phosphatidylinositol phospholipase C (C16:0,C16:0)
reactant: 027259
fast: false
kinetic law: 027319
reactant: 027271
product: 027283
product: 027307
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false

027295
type: SpeciesReference
stoichiometry: 1.0
species: 302819

027259
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309415
type: LocalParameter
units: 006281
value: 0.0

309413
type: LocalParameter
units: 006281
value: 0.0

309411
type: LocalParameter
units: 006281
value: 1000.0

309409
type: LocalParameter
units: 006281
value: 0.0

027271
type: SpeciesReference
stoichiometry: 1.0
species: 303053

027283
type: SpeciesReference
stoichiometry: 1.0
species: 302675

027307
type: SpeciesReference
stoichiometry: 1.0
species: 302921

304871
type: Reaction
kinetic law: 031986
product: 031974
reactant: 031962
notes: GENE_ASSOCIATION: Slc14a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Urea transport via facilitate diffusion

310015
type: LocalParameter
units: 006281
value: 0.0

310013
type: LocalParameter
units: 006281
value: 0.0

310011
type: LocalParameter
units: 006281
value: 1000.0

310009
type: LocalParameter
units: 006281
value: -1000.0

031974
type: SpeciesReference
stoichiometry: 1.0
species: 303233

031962
type: SpeciesReference
stoichiometry: 1.0
species: 303479

303656
type: Reaction
kinetic law: 007747
reactant: 007735
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Norepinephrine exchange

305585
type: LocalParameter
units: 006281
value: 0.0

305582
type: LocalParameter
units: 006281
value: 0.0

305579
type: LocalParameter
units: 006281
value: 0.0

305576
type: LocalParameter
units: 006281
value: -0.0288

007735
type: SpeciesReference
stoichiometry: 1.0
species: 303431

303833
type: Reaction
fast: false
name: adenosine kinase
notes: GENE_ASSOCIATION: Adk.2 or Adk.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reactant: 009836
product: 009872
kinetic law: 009884
reversible: false
product: 009848
reactant: 009824
product: 009860

009836
type: SpeciesReference
stoichiometry: 1.0
species: 302589

009872
type: SpeciesReference
stoichiometry: 1.0
species: 302819

306293
type: LocalParameter
units: 006281
value: 0.0

306290
type: LocalParameter
units: 006281
value: 0.0

306287
type: LocalParameter
units: 006281
value: 1000.0

306284
type: LocalParameter
units: 006281
value: 0.0

009848
type: SpeciesReference
stoichiometry: 1.0
species: 302549

009824
type: SpeciesReference
stoichiometry: 1.0
species: 302547

009860
type: SpeciesReference
stoichiometry: 1.0
species: 302578

303629
type: Reaction
kinetic law: 007529
reactant: 007517
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-Malate exchange

305477
type: LocalParameter
units: 006281
value: 0.0

305474
type: LocalParameter
units: 006281
value: 0.0

305471
type: LocalParameter
units: 006281
value: 0.25

305468
type: LocalParameter
units: 006281
value: -0.5

007517
type: SpeciesReference
stoichiometry: 1.0
species: 303404

304877
type: Reaction
product: 032083
notes: GENE_ASSOCIATION: Xylb.1 SUBSYSTEM: Pentose and Glucuronate Interconversions EC Number: Confidence Level: AUTHORS:
reactant: 032047
kinetic law: 032095
fast: false
product: 032071
reactant: 032034
name: xylulokinase
product: 032059
reversible: false

032083
type: SpeciesReference
stoichiometry: 1.0
species: 303245

032047
type: SpeciesReference
stoichiometry: 1.0
species: 303251

310031
type: LocalParameter
units: 006281
value: 0.0

310029
type: LocalParameter
units: 006281
value: 0.0

310027
type: LocalParameter
units: 006281
value: 1000.0

310025
type: LocalParameter
units: 006281
value: 0.0

032071
type: SpeciesReference
stoichiometry: 1.0
species: 302819

032034
type: SpeciesReference
stoichiometry: 1.0
species: 302589

032059
type: SpeciesReference
stoichiometry: 1.0
species: 302549

304362
type: Reaction
notes: GENE_ASSOCIATION: Mat2ab1 or Mat1a.1 or Mat2ab2 SUBSYSTEM: Methionine Metabolism EC Number: Confidence Level: AUTHORS:
product: 021220
product: 021208
kinetic law: 021232
reactant: 021160
name: methionine adenosyltransferase
product: 021196
reactant: 021172
reversible: false
reactant: 021184
fast: false

021220
type: SpeciesReference
stoichiometry: 1.0
species: 303143

021208
type: SpeciesReference
stoichiometry: 1.0
species: 303131

308415
type: LocalParameter
units: 006281
value: 0.0

308412
type: LocalParameter
units: 006281
value: 0.0

308409
type: LocalParameter
units: 006281
value: 1000.0

308406
type: LocalParameter
units: 006281
value: 0.0

021160
type: SpeciesReference
stoichiometry: 1.0
species: 302589

021196
type: SpeciesReference
stoichiometry: 1.0
species: 302572

021172
type: SpeciesReference
stoichiometry: 1.0
species: 302822

021184
type: SpeciesReference
stoichiometry: 1.0
species: 302906

304290
type: Reaction
kinetic law: 019819
product: 019807
reactant: 019794
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: proton diffusion

308127
type: LocalParameter
units: 006281
value: 0.0

308124
type: LocalParameter
units: 006281
value: 0.0

308121
type: LocalParameter
units: 006281
value: 1000.0

308118
type: LocalParameter
units: 006281
value: -1000.0

019807
type: SpeciesReference
stoichiometry: 1.0
species: 303362

019794
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303521
type: Reaction
kinetic law: 006655
reactant: 006643
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Bilirubin monoglucuronide exchange

305048
type: LocalParameter
units: 006281
value: 0.0

305045
type: LocalParameter
units: 006281
value: 0.0

305042
type: LocalParameter
units: 006281
value: 0.0025

305039
type: LocalParameter
units: 006281
value: 0.0

006643
type: SpeciesReference
stoichiometry: 1.0
species: 303296

304158
type: Reaction
product: 016917
reactant: 016881
kinetic law: 016941
notes: GENE_ASSOCIATION: Ugp2.2 or Ugp2.1 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 016905
name: UTP-glucose-1-phosphate uridylyltransferase
reactant: 016893
product: 016929
fast: false

016917
type: SpeciesReference
stoichiometry: 1.0
species: 303143

016881
type: SpeciesReference
stoichiometry: 1.0
species: 302748

307599
type: LocalParameter
units: 006281
value: 0.0

307596
type: LocalParameter
units: 006281
value: 0.0

307593
type: LocalParameter
units: 006281
value: 1000.0

307590
type: LocalParameter
units: 006281
value: -1000.0

016905
type: SpeciesReference
stoichiometry: 1.0
species: 303239

016893
type: SpeciesReference
stoichiometry: 1.0
species: 302819

016929
type: SpeciesReference
stoichiometry: 1.0
species: 303218

304335
type: Reaction
product: 020664
kinetic law: 020701
product: 020677
reactant: 020640
reactant: 020652
reversible: false
notes: GENE_ASSOCIATION: Lgals13 or Pla2g4a.1 or Clc.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 020689
name: lysophospholipase (C18:w)
fast: false

020664
type: SpeciesReference
stoichiometry: 1.0
species: 302753

308307
type: LocalParameter
units: 006281
value: 0.0

308304
type: LocalParameter
units: 006281
value: 0.0

308301
type: LocalParameter
units: 006281
value: 1000.0

308298
type: LocalParameter
units: 006281
value: 0.0

020677
type: SpeciesReference
stoichiometry: 1.0
species: 302819

020640
type: SpeciesReference
stoichiometry: 1.0
species: 302822

020652
type: SpeciesReference
stoichiometry: 1.0
species: 302888

020689
type: SpeciesReference
stoichiometry: 1.0
species: 302873

304742
type: Reaction
notes: GENE_ASSOCIATION: Np.1 SUBSYSTEM: Purine Catabolism EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 029307
reactant: 029295
product: 029331
name: purine-nucleoside phosphorylase (Inosine)
fast: false
product: 029319
kinetic law: 029343

029307
type: SpeciesReference
stoichiometry: 1.0
species: 303131

029295
type: SpeciesReference
stoichiometry: 1.0
species: 302852

029331
type: SpeciesReference
stoichiometry: 1.0
species: 303176

029319
type: SpeciesReference
stoichiometry: 1.0
species: 302840

309671
type: LocalParameter
units: 006281
value: 0.0

309669
type: LocalParameter
units: 006281
value: 0.0

309667
type: LocalParameter
units: 006281
value: 1000.0

309665
type: LocalParameter
units: 006281
value: -1000.0

303839
type: Reaction
reactant: 009944
kinetic law: 009980
reactant: 009932
notes: GENE_ASSOCIATION: AprT.1 SUBSYSTEM: Salvage Pathway EC Number: Confidence Level: AUTHORS:
fast: false
product: 009956
reversible: false
name: adenine phosphoribosyltransferase
product: 009968

009944
type: SpeciesReference
stoichiometry: 1.0
species: 303152

306317
type: LocalParameter
units: 006281
value: 0.0

306314
type: LocalParameter
units: 006281
value: 0.0

306311
type: LocalParameter
units: 006281
value: 1000.0

306308
type: LocalParameter
units: 006281
value: 0.0

009932
type: SpeciesReference
stoichiometry: 1.0
species: 302544

009956
type: SpeciesReference
stoichiometry: 1.0
species: 302578

009968
type: SpeciesReference
stoichiometry: 1.0
species: 303143

303767
type: Reaction
kinetic law: 008642
reactant: 008630
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink pe hs 18 1 18 1(c)

306029
type: LocalParameter
units: 006281
value: 0.0

306026
type: LocalParameter
units: 006281
value: 0.0

306023
type: LocalParameter
units: 006281
value: 10.0

306020
type: LocalParameter
units: 006281
value: -10.0

008630
type: SpeciesReference
stoichiometry: 1.0
species: 303107

303794
type: Reaction
kinetic law: 009102
product: 009090
reactant: 009078
notes: GENE_ASSOCIATION: Renbp.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: N-acetylglucosamine 2-epimerase

306137
type: LocalParameter
units: 006281
value: 0.0

306134
type: LocalParameter
units: 006281
value: 0.0

306131
type: LocalParameter
units: 006281
value: 1000.0

306128
type: LocalParameter
units: 006281
value: -1000.0

009090
type: SpeciesReference
stoichiometry: 1.0
species: 302532

009078
type: SpeciesReference
stoichiometry: 1.0
species: 302526

304043
type: Reaction
kinetic law: 014545
reactant: 014496
reactant: 014472
product: 014520
product: 014532
name: coproporphyrinogen oxidase (O2 required)
fast: false
product: 014508
reactant: 014484
reversible: false
notes: GENE_ASSOCIATION: Cpox.1 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:

307131
type: LocalParameter
units: 006281
value: 0.0

307128
type: LocalParameter
units: 006281
value: 0.0

307125
type: LocalParameter
units: 006281
value: 1000.0

307122
type: LocalParameter
units: 006281
value: 0.0

014496
type: SpeciesReference
stoichiometry: 1.0
species: 302966

014472
type: SpeciesReference
stoichiometry: 1.0
species: 302663

014520
type: SpeciesReference
stoichiometry: 2.0
species: 302822

014532
type: SpeciesReference
stoichiometry: 1.0
species: 303149

014508
type: SpeciesReference
stoichiometry: 2.0
species: 302657

014484
type: SpeciesReference
stoichiometry: 2.0
species: 302819

304296
type: Reaction
product: 019953
product: 019965
reactant: 019917
notes: GENE_ASSOCIATION: ImpDH1.1 or ImpDH2.1 or ImpDH1.2 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 019929
name: IMP dehydrogenase
kinetic law: 019977
fast: false
reactant: 019905
product: 019941

019953
type: SpeciesReference
stoichiometry: 1.0
species: 302936

019965
type: SpeciesReference
stoichiometry: 1.0
species: 303242

019917
type: SpeciesReference
stoichiometry: 1.0
species: 302846

019929
type: SpeciesReference
stoichiometry: 1.0
species: 302933

308151
type: LocalParameter
units: 006281
value: 0.0

308148
type: LocalParameter
units: 006281
value: 0.0

308145
type: LocalParameter
units: 006281
value: 1000.0

308142
type: LocalParameter
units: 006281
value: 0.0

019905
type: SpeciesReference
stoichiometry: 1.0
species: 302822

019941
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303977
type: Reaction
name: phosphatidate cytidylyltransferase (C18:2,C18:1)
product: 012994
reactant: 012957
reversible: false
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 012981
fast: false
kinetic law: 013006
reactant: 012969
reactant: 012945

012994
type: SpeciesReference
stoichiometry: 1.0
species: 303143

012957
type: SpeciesReference
stoichiometry: 1.0
species: 302819

012981
type: SpeciesReference
stoichiometry: 1.0
species: 302636

302636
type: Species
notes: CHARGE: 0
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 302469
name: CDP diacylglycerol (homo sapiens, C18:2, C18:1)

306869
type: LocalParameter
units: 006281
value: 0.0

306866
type: LocalParameter
units: 006281
value: 0.0

306863
type: LocalParameter
units: 006281
value: 1000.0

306860
type: LocalParameter
units: 006281
value: 0.0

012969
type: SpeciesReference
stoichiometry: 1.0
species: 303008

012945
type: SpeciesReference
stoichiometry: 1.0
species: 302669

304016
type: Reaction
product: 013910
notes: GENE_ASSOCIATION: Cept1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013934
reactant: 013886
kinetic law: 013946
product: 013922
reactant: 013898
reversible: false
name: ethanolamine phosphotransferase (C18:2,C16:0)
fast: false

013910
type: SpeciesReference
stoichiometry: 1.0
species: 302651

013934
type: SpeciesReference
stoichiometry: 1.0
species: 303113

013886
type: SpeciesReference
stoichiometry: 1.0
species: 302639

307025
type: LocalParameter
units: 006281
value: 0.0

307022
type: LocalParameter
units: 006281
value: 0.0

307019
type: LocalParameter
units: 006281
value: 1000.0

307016
type: LocalParameter
units: 006281
value: 0.0

013922
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013898
type: SpeciesReference
stoichiometry: 1.0
species: 302690

304269
type: Reaction
reactant: 019310
product: 019334
notes: GENE_ASSOCIATION: Hk1.3 or Hk1.2 or Hk1.5 or Flj22761.1 or Hk2.1 or Hk1.4 or Hk3.1 or Hk1.1 SUBSYSTEM: Aminosugar Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
product: 019322
kinetic law: 019358
name: hexokinase (D-glucosamine:ATP)
product: 019346
reactant: 019298
fast: false

019310
type: SpeciesReference
stoichiometry: 1.0
species: 302767

019334
type: SpeciesReference
stoichiometry: 1.0
species: 302769

019322
type: SpeciesReference
stoichiometry: 1.0
species: 302549

308043
type: LocalParameter
units: 006281
value: 0.0

308040
type: LocalParameter
units: 006281
value: 0.0

308037
type: LocalParameter
units: 006281
value: 1000.0

308034
type: LocalParameter
units: 006281
value: 0.0

019346
type: SpeciesReference
stoichiometry: 1.0
species: 302819

019298
type: SpeciesReference
stoichiometry: 1.0
species: 302589

304712
type: Reaction
product: 028762
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reversible: false
kinetic law: 028774
product: 028750
fast: false
name: phosphatidic acid phosphatase (C18:1,C18:2)
reactant: 028726
reactant: 028738

028762
type: SpeciesReference
stoichiometry: 1.0
species: 303131

309591
type: LocalParameter
units: 006281
value: 0.0

309589
type: LocalParameter
units: 006281
value: 0.0

309587
type: LocalParameter
units: 006281
value: 1000.0

309585
type: LocalParameter
units: 006281
value: 0.0

028750
type: SpeciesReference
stoichiometry: 1.0
species: 302687

028726
type: SpeciesReference
stoichiometry: 1.0
species: 302822

028738
type: SpeciesReference
stoichiometry: 1.0
species: 303002

303665
type: Reaction
kinetic law: 007819
reactant: 007807
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Orotate exchange

305621
type: LocalParameter
units: 006281
value: 0.0

305618
type: LocalParameter
units: 006281
value: 0.0

305615
type: LocalParameter
units: 006281
value: 0.0

305612
type: LocalParameter
units: 006281
value: -0.01

007807
type: SpeciesReference
stoichiometry: 1.0
species: 303440

303692
type: Reaction
kinetic law: 008038
reactant: 008026
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Spermidine exchange

305729
type: LocalParameter
units: 006281
value: 0.0

305726
type: LocalParameter
units: 006281
value: 0.0

305723
type: LocalParameter
units: 006281
value: 0.08

305720
type: LocalParameter
units: 006281
value: 0.0

008026
type: SpeciesReference
stoichiometry: 1.0
species: 303467

304479
type: Reaction
fast: false
reactant: 023595
product: 023632
reactant: 023608
kinetic law: 023644
reversible: true
notes: GENE_ASSOCIATION: Umps.1 SUBSYSTEM: Pyrimidine Biosynthesis EC Number: Confidence Level: AUTHORS:
product: 023620
name: orotate phosphoribosyltransferase

023595
type: SpeciesReference
stoichiometry: 1.0
species: 302987

023632
type: SpeciesReference
stoichiometry: 1.0
species: 303152

023608
type: SpeciesReference
stoichiometry: 1.0
species: 303143

308883
type: LocalParameter
units: 006281
value: 0.0

308880
type: LocalParameter
units: 006281
value: 0.0

308877
type: LocalParameter
units: 006281
value: 1000.0

308874
type: LocalParameter
units: 006281
value: -1000.0

023620
type: SpeciesReference
stoichiometry: 1.0
species: 302984

304653
type: Reaction
fast: false
product: 027452
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027416
product: 027440
reactant: 027404
product: 027428
name: phosphatidylinositol phospholipase C (C16:0,C18:2)
reversible: false
kinetic law: 027464

027452
type: SpeciesReference
stoichiometry: 1.0
species: 302921

027416
type: SpeciesReference
stoichiometry: 1.0
species: 303059

027440
type: SpeciesReference
stoichiometry: 1.0
species: 302819

027404
type: SpeciesReference
stoichiometry: 1.0
species: 302822

027428
type: SpeciesReference
stoichiometry: 1.0
species: 302681

309431
type: LocalParameter
units: 006281
value: 0.0

309429
type: LocalParameter
units: 006281
value: 0.0

309427
type: LocalParameter
units: 006281
value: 1000.0

309425
type: LocalParameter
units: 006281
value: 0.0

304626
type: Reaction
product: 026801
reactant: 026752
product: 026789
kinetic law: 026813
reactant: 026764
fast: false
reversible: false
product: 026777
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: phosphatidylinositol 4-kinase (C16:0,C16:0)

026801
type: SpeciesReference
stoichiometry: 1.0
species: 303032

026752
type: SpeciesReference
stoichiometry: 1.0
species: 302589

026789
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309359
type: LocalParameter
units: 006281
value: 0.0

309357
type: LocalParameter
units: 006281
value: 0.0

309355
type: LocalParameter
units: 006281
value: 1000.0

309353
type: LocalParameter
units: 006281
value: 0.0

026764
type: SpeciesReference
stoichiometry: 1.0
species: 303053

026777
type: SpeciesReference
stoichiometry: 1.0
species: 302549

304167
type: Reaction
product: 017075
fast: false
name: glyceraldehyde-3-phosphate dehydrogenase
reversible: true
notes: GENE_ASSOCIATION: Gapdh.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
product: 017063
reactant: 017039
reactant: 017027
reactant: 017051
kinetic law: 017099
product: 017087

017075
type: SpeciesReference
stoichiometry: 1.0
species: 302819

017063
type: SpeciesReference
stoichiometry: 1.0
species: 302473

017039
type: SpeciesReference
stoichiometry: 1.0
species: 302933

017027
type: SpeciesReference
stoichiometry: 1.0
species: 302751

017051
type: SpeciesReference
stoichiometry: 1.0
species: 303131

307635
type: LocalParameter
units: 006281
value: 0.0

307632
type: LocalParameter
units: 006281
value: 0.0

307629
type: LocalParameter
units: 006281
value: 1000.0

307626
type: LocalParameter
units: 006281
value: -1000.0

017087
type: SpeciesReference
stoichiometry: 1.0
species: 302936

303812
type: Reaction
kinetic law: 009478
product: 009466
name: acid phosphatase (FMN)
reversible: false
product: 009454
reactant: 009429
fast: false
notes: GENE_ASSOCIATION: Acp1.3 or Acp1.1 or Acp1.2 SUBSYSTEM: Riboflavin Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 009442

306209
type: LocalParameter
units: 006281
value: 0.0

306206
type: LocalParameter
units: 006281
value: 0.0

306203
type: LocalParameter
units: 006281
value: 1000.0

306200
type: LocalParameter
units: 006281
value: 0.0

009466
type: SpeciesReference
stoichiometry: 1.0
species: 303182

009454
type: SpeciesReference
stoichiometry: 1.0
species: 303131

009429
type: SpeciesReference
stoichiometry: 1.0
species: 302736

009442
type: SpeciesReference
stoichiometry: 1.0
species: 302822

303608
type: Reaction
kinetic law: 007360
reactant: 007348
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Inosine exchange

305393
type: LocalParameter
units: 006281
value: 0.0

305390
type: LocalParameter
units: 006281
value: 0.0

305387
type: LocalParameter
units: 006281
value: 0.024

305384
type: LocalParameter
units: 006281
value: 0.0

007348
type: SpeciesReference
stoichiometry: 1.0
species: 303383

304341
type: Reaction
kinetic law: 020785
product: 020773
reactant: 020761
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Malate exchange, diffusion

308331
type: LocalParameter
units: 006281
value: 0.0

308328
type: LocalParameter
units: 006281
value: 0.0

308325
type: LocalParameter
units: 006281
value: 1000.0

308322
type: LocalParameter
units: 006281
value: -1000.0

020773
type: SpeciesReference
stoichiometry: 1.0
species: 302891

020761
type: SpeciesReference
stoichiometry: 1.0
species: 303404

304052
type: Reaction
reactant: 014653
reactant: 014666
kinetic law: 014702
notes: GENE_ASSOCIATION: Slc16a1.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
product: 014690
product: 014678
reversible: true
name: D-lactate transport via proton symport

014653
type: SpeciesReference
stoichiometry: 1.0
species: 303362

014666
type: SpeciesReference
stoichiometry: 1.0
species: 303389

307167
type: LocalParameter
units: 006281
value: 0.0

307164
type: LocalParameter
units: 006281
value: 0.0

307161
type: LocalParameter
units: 006281
value: 1000.0

307158
type: LocalParameter
units: 006281
value: -1000.0

014690
type: SpeciesReference
stoichiometry: 1.0
species: 302858

014678
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303599
type: Reaction
kinetic law: 007287
reactant: 007275
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-homocysteine exchange

305357
type: LocalParameter
units: 006281
value: 0.0

305354
type: LocalParameter
units: 006281
value: 0.0

305351
type: LocalParameter
units: 006281
value: 0.01

305348
type: LocalParameter
units: 006281
value: 0.0

007275
type: SpeciesReference
stoichiometry: 1.0
species: 303374

303500
type: Reaction
kinetic law: 006485
reactant: 006473
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: N-Acetylneuraminate exchange

304964
type: LocalParameter
units: 006281
value: 0.0

304961
type: LocalParameter
units: 006281
value: 0.0

304958
type: LocalParameter
units: 006281
value: 0.0

304955
type: LocalParameter
units: 006281
value: -3.74E-5

006473
type: SpeciesReference
stoichiometry: 1.0
species: 303275

303950
type: Reaction
product: 012342
reactant: 012306
kinetic law: 012354
product: 012318
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
reactant: 012294
product: 012330
name: phosphatidylinositol synthase (Homo sapiens, C18:1,C18:2)

012342
type: SpeciesReference
stoichiometry: 1.0
species: 303065

012306
type: SpeciesReference
stoichiometry: 1.0
species: 302849

306761
type: LocalParameter
units: 006281
value: 0.0

306758
type: LocalParameter
units: 006281
value: 0.0

306755
type: LocalParameter
units: 006281
value: 1000.0

306752
type: LocalParameter
units: 006281
value: -1000.0

012318
type: SpeciesReference
stoichiometry: 1.0
species: 302651

012294
type: SpeciesReference
stoichiometry: 1.0
species: 302630

012330
type: SpeciesReference
stoichiometry: 1.0
species: 302819

303491
type: Reaction
kinetic law: 006413
reactant: 006401
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: 5-Amino-4-oxopentanoate exchange

304928
type: LocalParameter
units: 006281
value: 0.0

304925
type: LocalParameter
units: 006281
value: 0.0

304922
type: LocalParameter
units: 006281
value: 0.0

304919
type: LocalParameter
units: 006281
value: -0.02

006401
type: SpeciesReference
stoichiometry: 1.0
species: 303266

304829
type: Reaction
reversible: false
product: 031166
product: 031178
kinetic law: 031202
reactant: 031153
notes: GENE_ASSOCIATION: ThmtP.1 SUBSYSTEM: Thiamine Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
name: thiamine-triphosphatase
product: 031190
reactant: 031141

031166
type: SpeciesReference
stoichiometry: 1.0
species: 302819

031178
type: SpeciesReference
stoichiometry: 1.0
species: 303131

309903
type: LocalParameter
units: 006281
value: 0.0

309901
type: LocalParameter
units: 006281
value: 0.0

309899
type: LocalParameter
units: 006281
value: 1000.0

309897
type: LocalParameter
units: 006281
value: 0.0

031153
type: SpeciesReference
stoichiometry: 1.0
species: 303212

031190
type: SpeciesReference
stoichiometry: 1.0
species: 303209

031141
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304314
type: Reaction
kinetic law: 020278
product: 020266
reactant: 020254
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: leukotriene B4 transmembrane (homo sapiens) transport

308223
type: LocalParameter
units: 006281
value: 0.0

308220
type: LocalParameter
units: 006281
value: 0.0

308217
type: LocalParameter
units: 006281
value: 1000.0

308214
type: LocalParameter
units: 006281
value: -1000.0

020266
type: SpeciesReference
stoichiometry: 1.0
species: 302867

020254
type: SpeciesReference
stoichiometry: 1.0
species: 303398

304524
type: Reaction
reactant: 024453
product: 024466
notes: GENE_ASSOCIATION: Synj1.2 or Synj1.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 024441
product: 024478
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase (C16:0, C18:1)
fast: false
reversible: false
kinetic law: 024490

024453
type: SpeciesReference
stoichiometry: 1.0
species: 303014

024466
type: SpeciesReference
stoichiometry: 1.0
species: 303035

024441
type: SpeciesReference
stoichiometry: 1.0
species: 302822

024478
type: SpeciesReference
stoichiometry: 1.0
species: 303131

309063
type: LocalParameter
units: 006281
value: 0.0

309060
type: LocalParameter
units: 006281
value: 0.0

309057
type: LocalParameter
units: 006281
value: 1000.0

309054
type: LocalParameter
units: 006281
value: 0.0

303818
type: Reaction
product: 009598
fast: false
name: Adenosine deaminase
reactant: 009550
reactant: 009574
kinetic law: 009610
notes: GENE_ASSOCIATION: Ada.1 SUBSYSTEM: Purine Catabolism EC Number: Confidence Level: AUTHORS:
reactant: 009562
product: 009586
reversible: false

009598
type: SpeciesReference
stoichiometry: 1.0
species: 302948

009550
type: SpeciesReference
stoichiometry: 1.0
species: 302547

009574
type: SpeciesReference
stoichiometry: 1.0
species: 302822

306233
type: LocalParameter
units: 006281
value: 0.0

306230
type: LocalParameter
units: 006281
value: 0.0

306227
type: LocalParameter
units: 006281
value: 1000.0

306224
type: LocalParameter
units: 006281
value: 0.0

009562
type: SpeciesReference
stoichiometry: 1.0
species: 302819

009586
type: SpeciesReference
stoichiometry: 1.0
species: 302852

304721
type: Reaction
fast: false
product: 028918
reactant: 028906
notes: GENE_ASSOCIATION: Alad.1 or Alad.2 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
product: 028942
reversible: false
kinetic law: 028954
name: porphobilinogen synthase
product: 028930

028918
type: SpeciesReference
stoichiometry: 1.0
species: 302819

028906
type: SpeciesReference
stoichiometry: 2.0
species: 302499

028942
type: SpeciesReference
stoichiometry: 1.0
species: 303140

309615
type: LocalParameter
units: 006281
value: 0.0

309613
type: LocalParameter
units: 006281
value: 0.0

309611
type: LocalParameter
units: 006281
value: 1000.0

309609
type: LocalParameter
units: 006281
value: 0.0

028930
type: SpeciesReference
stoichiometry: 2.0
species: 302822

303710
type: Reaction
kinetic law: 008183
reactant: 008171
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: sink adprbp(c)

305801
type: LocalParameter
units: 006281
value: 0.0

305798
type: LocalParameter
units: 006281
value: 0.0

305795
type: LocalParameter
units: 006281
value: 10.0

305792
type: LocalParameter
units: 006281
value: -10.0

008171
type: SpeciesReference
stoichiometry: 1.0
species: 302552

304275
type: Reaction
product: 019480
name: hexokinase (D-fructose:ATP)
kinetic law: 019504
reactant: 019444
product: 019492
reactant: 019456
reversible: false
product: 019468
notes: GENE_ASSOCIATION: Hk1.4 or Hk3.1 or Hk1.1 or Hk1.5 or Hk2.1 or Hk1.3 or Flj22761.1 or Hk1.2 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
fast: false

019480
type: SpeciesReference
stoichiometry: 1.0
species: 302726

308067
type: LocalParameter
units: 006281
value: 0.0

308064
type: LocalParameter
units: 006281
value: 0.0

308061
type: LocalParameter
units: 006281
value: 1000.0

308058
type: LocalParameter
units: 006281
value: 0.0

019444
type: SpeciesReference
stoichiometry: 1.0
species: 302589

019492
type: SpeciesReference
stoichiometry: 1.0
species: 302819

019456
type: SpeciesReference
stoichiometry: 1.0
species: 302742

019468
type: SpeciesReference
stoichiometry: 1.0
species: 302549

304058
type: Reaction
kinetic law: 014846
fast: false
product: 014810
notes: GENE_ASSOCIATION: Dgkb.2 or Dgkz.3 or Dgkz.1 or Dgkb.1 or Dgkb.1 or Dgkd.2 or Dgkz.2 or Dgkd.1 or Dgka.1 or Dgkq.1 or Dgkh.2 or Dgki.1 or Dgkh.1 or Dgkg.1 or Dgke.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
name: Diacylglycerol phosphate kinase (homo sapiens, C16:0, C18:1)
product: 014834
reactant: 014798
reversible: true
reactant: 014786
product: 014822

307191
type: LocalParameter
units: 006281
value: 0.0

307188
type: LocalParameter
units: 006281
value: 0.0

307185
type: LocalParameter
units: 006281
value: 1000.0

307182
type: LocalParameter
units: 006281
value: -1000.0

014810
type: SpeciesReference
stoichiometry: 1.0
species: 302549

014834
type: SpeciesReference
stoichiometry: 1.0
species: 302993

014798
type: SpeciesReference
stoichiometry: 1.0
species: 302678

014786
type: SpeciesReference
stoichiometry: 1.0
species: 302589

014822
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304452
type: Reaction
kinetic law: 023052
product: 023040
name: 5'-nucleotidase (AMP)
fast: false
product: 023028
reactant: 023004
reversible: false
reactant: 023016
notes: GENE_ASSOCIATION: Nt5C2.1 SUBSYSTEM: Nucleotides EC Number: Confidence Level: AUTHORS:

308775
type: LocalParameter
units: 006281
value: 0.0

308772
type: LocalParameter
units: 006281
value: 0.0

308769
type: LocalParameter
units: 006281
value: 1000.0

308766
type: LocalParameter
units: 006281
value: 0.0

023040
type: SpeciesReference
stoichiometry: 1.0
species: 303131

023028
type: SpeciesReference
stoichiometry: 1.0
species: 302547

023004
type: SpeciesReference
stoichiometry: 1.0
species: 302578

023016
type: SpeciesReference
stoichiometry: 1.0
species: 302822

303506
type: Reaction
kinetic law: 006534
reactant: 006521
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Adenosine exchange

304988
type: LocalParameter
units: 006281
value: 0.0

304985
type: LocalParameter
units: 006281
value: 0.0

304982
type: LocalParameter
units: 006281
value: 0.014

304979
type: LocalParameter
units: 006281
value: -0.01

006521
type: SpeciesReference
stoichiometry: 1.0
species: 303281

303956
type: Reaction
product: 012462
kinetic law: 012498
product: 012486
fast: false
notes: GENE_ASSOCIATION: Cdipt.2 or Cdipt.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 012438
reactant: 012450
reversible: true
name: phosphatidylinositol synthase (Homo sapiens, C18:2,C18:1)
product: 012474

012462
type: SpeciesReference
stoichiometry: 1.0
species: 302651

306785
type: LocalParameter
units: 006281
value: 0.0

306782
type: LocalParameter
units: 006281
value: 0.0

306779
type: LocalParameter
units: 006281
value: 1000.0

306776
type: LocalParameter
units: 006281
value: -1000.0

012486
type: SpeciesReference
stoichiometry: 1.0
species: 303071

012438
type: SpeciesReference
stoichiometry: 1.0
species: 302636

012450
type: SpeciesReference
stoichiometry: 1.0
species: 302849

012474
type: SpeciesReference
stoichiometry: 1.0
species: 302819

304727
type: Reaction
product: 029039
fast: false
product: 029027
reactant: 029015
kinetic law: 029051
reactant: 029003
reversible: false
notes: GENE_ASSOCIATION: SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
name: protoporphyrinogen oxidase (aerobic)

029039
type: SpeciesReference
stoichiometry: 1.0
species: 303146

029027
type: SpeciesReference
stoichiometry: 3.0
species: 302822

029015
type: SpeciesReference
stoichiometry: 1.0
species: 303149

309631
type: LocalParameter
units: 006281
value: 0.0

309629
type: LocalParameter
units: 006281
value: 0.0

309627
type: LocalParameter
units: 006281
value: 1000.0

309625
type: LocalParameter
units: 006281
value: 0.0

029003
type: SpeciesReference
stoichiometry: 1.5
species: 302966

304212
type: Reaction
reversible: false
kinetic law: 018165
product: 018152
product: 018140
fast: false
reactant: 018128
reactant: 018116
notes: GENE_ASSOCIATION: Gpam.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
name: glycerol-3-phosphate acyltransferase (C18:1)

307815
type: LocalParameter
units: 006281
value: 0.0

307812
type: LocalParameter
units: 006281
value: 0.0

307809
type: LocalParameter
units: 006281
value: 1000.0

307806
type: LocalParameter
units: 006281
value: 0.0

018152
type: SpeciesReference
stoichiometry: 1.0
species: 302660

018140
type: SpeciesReference
stoichiometry: 1.0
species: 302567

018128
type: SpeciesReference
stoichiometry: 1.0
species: 302975

018116
type: SpeciesReference
stoichiometry: 1.0
species: 302795

304682
type: Reaction
reversible: false
name: phospholipase A2 (C18:1,C18:2)
product: 028145
product: 028133
reactant: 028097
reactant: 028109
notes: GENE_ASSOCIATION: Pla2g6.1 or Pla2g6.2 or Pla2g2a.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 028121
fast: false
kinetic law: 028157

028145
type: SpeciesReference
stoichiometry: 1.0
species: 302885

028133
type: SpeciesReference
stoichiometry: 1.0
species: 302873

028097
type: SpeciesReference
stoichiometry: 1.0
species: 302822

028109
type: SpeciesReference
stoichiometry: 1.0
species: 303086

028121
type: SpeciesReference
stoichiometry: 1.0
species: 302819

309511
type: LocalParameter
units: 006281
value: 0.0

309509
type: LocalParameter
units: 006281
value: 0.0

309507
type: LocalParameter
units: 006281
value: 1000.0

309505
type: LocalParameter
units: 006281
value: 0.0

304140
type: Reaction
kinetic law: 016515
product: 016503
reactant: 016491
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Fumarate transport via diffusion (reversible)

307527
type: LocalParameter
units: 006281
value: 0.0

307524
type: LocalParameter
units: 006281
value: 0.0

307521
type: LocalParameter
units: 006281
value: 1000.0

307518
type: LocalParameter
units: 006281
value: -1000.0

016503
type: SpeciesReference
stoichiometry: 1.0
species: 302745

016491
type: SpeciesReference
stoichiometry: 1.0
species: 303335

303929
type: Reaction
product: 011833
product: 011821
reversible: false
product: 011809
reactant: 011785
product: 011797
reactant: 011773
fast: false
notes: GENE_ASSOCIATION: Atp2b1.1 or Atp2b4.1 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
kinetic law: 011845
name: Ca ATPase
reactant: 011761

011833
type: SpeciesReference
stoichiometry: 1.0
species: 303362

011821
type: SpeciesReference
stoichiometry: 2.0
species: 303299

011809
type: SpeciesReference
stoichiometry: 1.0
species: 303131

011785
type: SpeciesReference
stoichiometry: 1.0
species: 302822

011797
type: SpeciesReference
stoichiometry: 1.0
species: 302549

011773
type: SpeciesReference
stoichiometry: 2.0
species: 302606

306677
type: LocalParameter
units: 006281
value: 0.0

306674
type: LocalParameter
units: 006281
value: 0.0

306671
type: LocalParameter
units: 006281
value: 1000.0

306668
type: LocalParameter
units: 006281
value: 0.0

011761
type: SpeciesReference
stoichiometry: 1.0
species: 302589

304662
type: Reaction
product: 027644
reactant: 027632
name: phosphatidylinositol phospholipase C (C18:2,C16:0)
kinetic law: 027680
product: 027656
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027620
fast: false
product: 027668

027644
type: SpeciesReference
stoichiometry: 1.0
species: 302690

027632
type: SpeciesReference
stoichiometry: 1.0
species: 303068

309455
type: LocalParameter
units: 006281
value: 0.0

309453
type: LocalParameter
units: 006281
value: 0.0

309451
type: LocalParameter
units: 006281
value: 1000.0

309449
type: LocalParameter
units: 006281
value: 0.0

027656
type: SpeciesReference
stoichiometry: 1.0
species: 302819

027620
type: SpeciesReference
stoichiometry: 1.0
species: 302822

027668
type: SpeciesReference
stoichiometry: 1.0
species: 302921

303644
type: Reaction
kinetic law: 007650
reactant: 007638
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Nicotinate exchange

305537
type: LocalParameter
units: 006281
value: 0.0

305534
type: LocalParameter
units: 006281
value: 0.0

305531
type: LocalParameter
units: 006281
value: 0.0

305528
type: LocalParameter
units: 006281
value: -0.001

007638
type: SpeciesReference
stoichiometry: 1.0
species: 303419

304458
type: Reaction
product: 023196
reactant: 023124
product: 023208
reactant: 023136
product: 023220
reactant: 023160
product: 023172
kinetic law: 023232
product: 023184
name: Na+/K+ exchanging ATPase
reactant: 023148
fast: false
notes: GENE_ASSOCIATION: Atp1a1b1 or Atp1a1b2 or Atp1a1b3 or Atp1a1b4 SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reversible: false

023196
type: SpeciesReference
stoichiometry: 2.0
species: 302855

023124
type: SpeciesReference
stoichiometry: 1.0
species: 302589

023208
type: SpeciesReference
stoichiometry: 1.0
species: 303131

023136
type: SpeciesReference
stoichiometry: 1.0
species: 302822

023220
type: SpeciesReference
stoichiometry: 3.0
species: 303416

023160
type: SpeciesReference
stoichiometry: 2.0
species: 303386

023172
type: SpeciesReference
stoichiometry: 1.0
species: 302549

308799
type: LocalParameter
units: 006281
value: 1.0

308796
type: LocalParameter
units: 006281
value: 0.0

308793
type: LocalParameter
units: 006281
value: 1000.0

308790
type: LocalParameter
units: 006281
value: 0.0

023184
type: SpeciesReference
stoichiometry: 1.0
species: 302819

023148
type: SpeciesReference
stoichiometry: 3.0
species: 302927

304865
type: Reaction
kinetic law: 031890
product: 031878
product: 031866
reactant: 031854
notes: GENE_ASSOCIATION: Uros.1 SUBSYSTEM: Heme Biosynthesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: uroporphyrinogen-III synthase

309999
type: LocalParameter
units: 006281
value: 0.0

309997
type: LocalParameter
units: 006281
value: 0.0

309995
type: LocalParameter
units: 006281
value: 1000.0

309993
type: LocalParameter
units: 006281
value: 0.0

031878
type: SpeciesReference
stoichiometry: 1.0
species: 303230

031866
type: SpeciesReference
stoichiometry: 1.0
species: 302822

031854
type: SpeciesReference
stoichiometry: 1.0
species: 302837

304668
type: Reaction
kinetic law: 027788
product: 027776
reactant: 027764
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Inorganic phosphate exchange, diffusion

309471
type: LocalParameter
units: 006281
value: 0.0

309469
type: LocalParameter
units: 006281
value: 0.0

309467
type: LocalParameter
units: 006281
value: 1000.0

309465
type: LocalParameter
units: 006281
value: -1000.0

027776
type: SpeciesReference
stoichiometry: 1.0
species: 303446

027764
type: SpeciesReference
stoichiometry: 1.0
species: 303131

303617
type: Reaction
kinetic law: 007433
reactant: 007421
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Lactate exchange

305429
type: LocalParameter
units: 006281
value: 0.0

305426
type: LocalParameter
units: 006281
value: 0.0

305423
type: LocalParameter
units: 006281
value: 3.67559263333338

305420
type: LocalParameter
units: 006281
value: 0.0

007421
type: SpeciesReference
stoichiometry: 1.0
species: 303392

304350
type: Reaction
reactant: 020882
product: 020907
product: 020894
fast: false
product: 020919
name: malate dehydrogenase
notes: GENE_ASSOCIATION: Mdh1.1 SUBSYSTEM: Citric Acid Cycle EC Number: Confidence Level: AUTHORS:
reactant: 020870
reversible: true
kinetic law: 020932

020882
type: SpeciesReference
stoichiometry: 1.0
species: 302933

020907
type: SpeciesReference
stoichiometry: 1.0
species: 302936

020894
type: SpeciesReference
stoichiometry: 1.0
species: 302819

020919
type: SpeciesReference
stoichiometry: 1.0
species: 302969

020870
type: SpeciesReference
stoichiometry: 1.0
species: 302891

308367
type: LocalParameter
units: 006281
value: 0.0

308364
type: LocalParameter
units: 006281
value: 0.0

308361
type: LocalParameter
units: 006281
value: 1000.0

308358
type: LocalParameter
units: 006281
value: -1000.0

303854
type: Reaction
notes: GENE_ASSOCIATION: Agpat3.2 or Agpat5.1 or Agpat3.1 or Agpat6.1 or Agpat1.1 or Agpat2.1 or Agpat4.1 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
product: 010246
reversible: false
fast: false
reactant: 010210
reactant: 010222
name: 1-acylglycerol-3-phosphate O-acyltransferase 1 (C16:0, C18:2)
kinetic law: 010258
product: 010234

010246
type: SpeciesReference
stoichiometry: 1.0
species: 302996

010210
type: SpeciesReference
stoichiometry: 1.0
species: 302564

010222
type: SpeciesReference
stoichiometry: 1.0
species: 302876

306377
type: LocalParameter
units: 006281
value: 0.0

306374
type: LocalParameter
units: 006281
value: 0.0

306371
type: LocalParameter
units: 006281
value: 1000.0

306368
type: LocalParameter
units: 006281
value: 0.0

010234
type: SpeciesReference
stoichiometry: 1.0
species: 302660

304146
type: Reaction
reactant: 016587
product: 016623
fast: false
name: glucose 6-phosphate dehydrogenase
product: 016635
product: 016611
notes: GENE_ASSOCIATION: G6pd.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
reversible: true
reactant: 016599
kinetic law: 016647

016587
type: SpeciesReference
stoichiometry: 1.0
species: 302756

016623
type: SpeciesReference
stoichiometry: 1.0
species: 302819

016635
type: SpeciesReference
stoichiometry: 1.0
species: 302942

016611
type: SpeciesReference
stoichiometry: 1.0
species: 302517

016599
type: SpeciesReference
stoichiometry: 1.0
species: 302939

307551
type: LocalParameter
units: 006281
value: 0.0

307548
type: LocalParameter
units: 006281
value: 0.0

307545
type: LocalParameter
units: 006281
value: 1000.0

307542
type: LocalParameter
units: 006281
value: -1000.0

304838
type: Reaction
name: transketolase
fast: false
reactant: 031313
product: 031337
reactant: 031325
notes: GENE_ASSOCIATION: Tkt.1 SUBSYSTEM: Pentose Phosphate Pathway EC Number: Confidence Level: AUTHORS:
kinetic law: 031361
reversible: true
product: 031349

031313
type: SpeciesReference
stoichiometry: 1.0
species: 302714

031337
type: SpeciesReference
stoichiometry: 1.0
species: 302726

031325
type: SpeciesReference
stoichiometry: 1.0
species: 303245

309927
type: LocalParameter
units: 006281
value: 0.0

309925
type: LocalParameter
units: 006281
value: 0.0

309923
type: LocalParameter
units: 006281
value: 1000.0

309921
type: LocalParameter
units: 006281
value: -1000.0

031349
type: SpeciesReference
stoichiometry: 1.0
species: 302751

304596
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: Plcb3.1 SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
product: 026145
product: 026133
fast: false
reactant: 026121
name: phosphatidylinositol 4-phosphate phospholipase C (C18:1,C18:2)
reactant: 026109
kinetic law: 026169
product: 026157

026145
type: SpeciesReference
stoichiometry: 1.0
species: 302819

026133
type: SpeciesReference
stoichiometry: 1.0
species: 302687

026121
type: SpeciesReference
stoichiometry: 1.0
species: 303044

026109
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309279
type: LocalParameter
units: 006281
value: 0.0

309277
type: LocalParameter
units: 006281
value: 0.0

309275
type: LocalParameter
units: 006281
value: 1000.0

309273
type: LocalParameter
units: 006281
value: 0.0

026157
type: SpeciesReference
stoichiometry: 1.0
species: 302918

303827
type: Reaction
product: 009751
notes: GENE_ASSOCIATION: Amd1.1 SUBSYSTEM: Arginine and Proline Metabolism EC Number: Confidence Level: AUTHORS:
reversible: false
fast: false
reactant: 009711
name: adenosylmethionine decarboxylase
product: 009737
reactant: 009724
kinetic law: 009764

009751
type: SpeciesReference
stoichiometry: 1.0
species: 302657

009711
type: SpeciesReference
stoichiometry: 1.0
species: 302572

009737
type: SpeciesReference
stoichiometry: 1.0
species: 302575

009724
type: SpeciesReference
stoichiometry: 1.0
species: 302819

306269
type: LocalParameter
units: 006281
value: 0.0

306266
type: LocalParameter
units: 006281
value: 0.0

306263
type: LocalParameter
units: 006281
value: 1000.0

306260
type: LocalParameter
units: 006281
value: 0.0

303782
type: Reaction
product: 008824
reactant: 008788
reactant: 008812
product: 008860
kinetic law: 008872
reactant: 008800
name: 3-Methoxytyramine secretion via secretory vesicle (ATP driven)
reversible: false
product: 008848
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
product: 008836

008824
type: SpeciesReference
stoichiometry: 2.0
species: 302549

008788
type: SpeciesReference
stoichiometry: 3.0
species: 302490

008812
type: SpeciesReference
stoichiometry: 2.0
species: 302822

008860
type: SpeciesReference
stoichiometry: 3.0
species: 303260

306089
type: LocalParameter
units: 006281
value: 0.0

306086
type: LocalParameter
units: 006281
value: 0.0

306083
type: LocalParameter
units: 006281
value: 1000.0

306080
type: LocalParameter
units: 006281
value: 0.0

008800
type: SpeciesReference
stoichiometry: 2.0
species: 302589

008848
type: SpeciesReference
stoichiometry: 2.0
species: 303131

008836
type: SpeciesReference
stoichiometry: 2.0
species: 302819

304119
type: Reaction
kinetic law: 016166
product: 016154
product: 016142
reactant: 016130
notes: GENE_ASSOCIATION: Aldoc.1 or Aldoa.2 or Aldoa.1 or Aldoa.3 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: fructose-bisphosphate aldolase

307443
type: LocalParameter
units: 006281
value: 0.0

307440
type: LocalParameter
units: 006281
value: 0.0

307437
type: LocalParameter
units: 006281
value: 1000.0

307434
type: LocalParameter
units: 006281
value: -1000.0

016154
type: SpeciesReference
stoichiometry: 1.0
species: 302751

016142
type: SpeciesReference
stoichiometry: 1.0
species: 302696

016130
type: SpeciesReference
stoichiometry: 1.0
species: 302731

303992
type: Reaction
name: choline phosphotransferase (C18:1, C18:2)
kinetic law: 013370
reactant: 013310
reactant: 013322
notes: GENE_ASSOCIATION: Cept1 or Chpt1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 013346
product: 013358
fast: false
product: 013334
reversible: false

306929
type: LocalParameter
units: 006281
value: 0.0

306926
type: LocalParameter
units: 006281
value: 0.0

306923
type: LocalParameter
units: 006281
value: 1000.0

306920
type: LocalParameter
units: 006281
value: 0.0

013310
type: SpeciesReference
stoichiometry: 1.0
species: 302615

013322
type: SpeciesReference
stoichiometry: 1.0
species: 302687

013346
type: SpeciesReference
stoichiometry: 1.0
species: 302819

013358
type: SpeciesReference
stoichiometry: 1.0
species: 303086

013334
type: SpeciesReference
stoichiometry: 1.0
species: 302651

304031
type: Reaction
notes: GENE_ASSOCIATION: Chkl.2 or Chkl.1 or Chk.2 or Chk.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
product: 014314
fast: false
reversible: false
reactant: 014278
product: 014290
reactant: 014266
name: Choline kinase
kinetic law: 014326
product: 014302

014314
type: SpeciesReference
stoichiometry: 1.0
species: 302819

014278
type: SpeciesReference
stoichiometry: 1.0
species: 302642

014290
type: SpeciesReference
stoichiometry: 1.0
species: 302549

014266
type: SpeciesReference
stoichiometry: 1.0
species: 302589

307083
type: LocalParameter
units: 006281
value: 0.0

307080
type: LocalParameter
units: 006281
value: 0.0

307077
type: LocalParameter
units: 006281
value: 1000.0

307074
type: LocalParameter
units: 006281
value: 0.0

014302
type: SpeciesReference
stoichiometry: 1.0
species: 302645

304284
type: Reaction
reversible: false
product: 019721
kinetic law: 019746
product: 019733
fast: false
reactant: 019709
name: hypoxanthine phosphoribosyltransferase (Hypoxanthine)
notes: GENE_ASSOCIATION: HprT1.1 SUBSYSTEM: Salvage Pathway EC Number: Confidence Level: AUTHORS:
reactant: 019697

019721
type: SpeciesReference
stoichiometry: 1.0
species: 302846

308103
type: LocalParameter
units: 006281
value: 0.0

308100
type: LocalParameter
units: 006281
value: 0.0

308097
type: LocalParameter
units: 006281
value: 1000.0

308094
type: LocalParameter
units: 006281
value: 0.0

019733
type: SpeciesReference
stoichiometry: 1.0
species: 303143

019709
type: SpeciesReference
stoichiometry: 1.0
species: 303152

019697
type: SpeciesReference
stoichiometry: 1.0
species: 302840

303578
type: Reaction
kinetic law: 007118
reactant: 007105
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: Glycine exchange

305273
type: LocalParameter
units: 006281
value: 0.0

305270
type: LocalParameter
units: 006281
value: 0.0

305267
type: LocalParameter
units: 006281
value: 0.0

305264
type: LocalParameter
units: 006281
value: -0.08

007105
type: SpeciesReference
stoichiometry: 1.0
species: 303353

303788
type: Reaction
fast: false
kinetic law: 009030
product: 009006
reactant: 008982
product: 009018
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
reactant: 008994
reversible: false
name: 5-Aminolevulinate transport in via proton symport

306113
type: LocalParameter
units: 006281
value: 0.0

306110
type: LocalParameter
units: 006281
value: 0.0

306107
type: LocalParameter
units: 006281
value: 1000.0

306104
type: LocalParameter
units: 006281
value: 0.0

009006
type: SpeciesReference
stoichiometry: 1.0
species: 302499

008982
type: SpeciesReference
stoichiometry: 1.0
species: 303266

009018
type: SpeciesReference
stoichiometry: 1.0
species: 302819

008994
type: SpeciesReference
stoichiometry: 1.0
species: 303362

303965
type: Reaction
reactant: 012668
fast: false
product: 012692
reactant: 012656
notes: GENE_ASSOCIATION: Cds1.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 012680
name: phosphatidate cytidylyltransferase (C16:0, C18:2)
product: 012704
reversible: false
kinetic law: 012716

012668
type: SpeciesReference
stoichiometry: 1.0
species: 302819

012692
type: SpeciesReference
stoichiometry: 1.0
species: 302624

012656
type: SpeciesReference
stoichiometry: 1.0
species: 302669

012680
type: SpeciesReference
stoichiometry: 1.0
species: 302996

012704
type: SpeciesReference
stoichiometry: 1.0
species: 303143

306821
type: LocalParameter
units: 006281
value: 0.0

306818
type: LocalParameter
units: 006281
value: 0.0

306815
type: LocalParameter
units: 006281
value: 1000.0

306812
type: LocalParameter
units: 006281
value: 0.0

304799
type: Reaction
product: 030549
reactant: 030525
reversible: false
notes: GENE_ASSOCIATION: Comtd1.1 SUBSYSTEM: Tyrosine metabolism EC Number: Confidence Level: AUTHORS:
name: S-Adenosyl-L-methionine:catechol O-methyltransferase
product: 030561
reactant: 030513
kinetic law: 030573
product: 030537
fast: false

030549
type: SpeciesReference
stoichiometry: 1.0
species: 302819

030525
type: SpeciesReference
stoichiometry: 1.0
species: 302572

030561
type: SpeciesReference
stoichiometry: 1.0
species: 302903

030513
type: SpeciesReference
stoichiometry: 1.0
species: 302554

309823
type: LocalParameter
units: 006281
value: 0.0

309821
type: LocalParameter
units: 006281
value: 0.0

309819
type: LocalParameter
units: 006281
value: 1000.0

309817
type: LocalParameter
units: 006281
value: 0.0

030537
type: SpeciesReference
stoichiometry: 1.0
species: 302556

304503
type: Reaction
reversible: true
product: 024115
reactant: 024103
reactant: 024090
name: phosphoglycerate kinase
product: 024127
kinetic law: 024139
fast: false
notes: GENE_ASSOCIATION: Pgk1.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:

024115
type: SpeciesReference
stoichiometry: 1.0
species: 302473

024103
type: SpeciesReference
stoichiometry: 1.0
species: 302589

024090
type: SpeciesReference
stoichiometry: 1.0
species: 302493

024127
type: SpeciesReference
stoichiometry: 1.0
species: 302549

308979
type: LocalParameter
units: 006281
value: 0.0

308976
type: LocalParameter
units: 006281
value: 0.0

308973
type: LocalParameter
units: 006281
value: 1000.0

308970
type: LocalParameter
units: 006281
value: -1000.0

304700
type: Reaction
notes: GENE_ASSOCIATION: Ppap2c.1 or Ppap2b.1 or Ppap2a.1 or Ppap2a.2 SUBSYSTEM: Diacylglycerol Synthesis EC Number: Confidence Level: AUTHORS:
reversible: false
reactant: 028485
fast: false
kinetic law: 028533
product: 028509
product: 028521
reactant: 028497
name: phosphatidic acid phosphatase (C16:0, C16:0)

028485
type: SpeciesReference
stoichiometry: 1.0
species: 302822

309559
type: LocalParameter
units: 006281
value: 0.0

309557
type: LocalParameter
units: 006281
value: 0.0

309555
type: LocalParameter
units: 006281
value: 1000.0

309553
type: LocalParameter
units: 006281
value: 0.0

028509
type: SpeciesReference
stoichiometry: 1.0
species: 302675

028521
type: SpeciesReference
stoichiometry: 1.0
species: 303131

028497
type: SpeciesReference
stoichiometry: 1.0
species: 302990

304494
type: Reaction
notes: GENE_ASSOCIATION: Pfkl.2 or Pfkm.1 or Pfkl.1 SUBSYSTEM: Glycolysis/Gluconeogenesis EC Number: Confidence Level: AUTHORS:
product: 023958
reactant: 023910
fast: false
product: 023946
name: phosphofructokinase
reversible: false
reactant: 023922
product: 023934
kinetic law: 023970

023958
type: SpeciesReference
stoichiometry: 1.0
species: 302819

023910
type: SpeciesReference
stoichiometry: 1.0
species: 302589

023946
type: SpeciesReference
stoichiometry: 1.0
species: 302731

023922
type: SpeciesReference
stoichiometry: 1.0
species: 302726

023934
type: SpeciesReference
stoichiometry: 1.0
species: 302549

308943
type: LocalParameter
units: 006281
value: 0.0

308940
type: LocalParameter
units: 006281
value: 0.0

308937
type: LocalParameter
units: 006281
value: 1000.0

308934
type: LocalParameter
units: 006281
value: 0.0

304691
type: Reaction
kinetic law: 028340
product: 028328
reactant: 028316
notes: GENE_ASSOCIATION: Pgm2 or Pmm2.1 SUBSYSTEM: Fructose and Mannose Metabolism EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: phosphomannomutase

309535
type: LocalParameter
units: 006281
value: 0.0

309533
type: LocalParameter
units: 006281
value: 0.0

309531
type: LocalParameter
units: 006281
value: 1000.0

309529
type: LocalParameter
units: 006281
value: -1000.0

028328
type: SpeciesReference
stoichiometry: 1.0
species: 302900

028316
type: SpeciesReference
stoichiometry: 1.0
species: 302897

303653
type: Reaction
kinetic law: 007722
reactant: 007710
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: L-Normetanephrine exchange

305573
type: LocalParameter
units: 006281
value: 0.0

305570
type: LocalParameter
units: 006281
value: 0.0

305567
type: LocalParameter
units: 006281
value: 0.0288

305564
type: LocalParameter
units: 006281
value: 0.0

007710
type: SpeciesReference
stoichiometry: 1.0
species: 303428

303680
type: Reaction
kinetic law: 007940
reactant: 007928
notes: GENE_ASSOCIATION: SUBSYSTEM: EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: Pyridoxal exchange

305681
type: LocalParameter
units: 006281
value: 0.0

305678
type: LocalParameter
units: 006281
value: 0.0

305675
type: LocalParameter
units: 006281
value: 2.28E-4

305672
type: LocalParameter
units: 006281
value: -1.55E-4

007928
type: SpeciesReference
stoichiometry: 1.0
species: 303455

304037
type: Reaction
kinetic law: 014424
product: 014412
reactant: 014400
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: CO2 transporter via diffusion

307107
type: LocalParameter
units: 006281
value: 0.0

307104
type: LocalParameter
units: 006281
value: 0.0

307101
type: LocalParameter
units: 006281
value: 1000.0

307098
type: LocalParameter
units: 006281
value: -1000.0

014412
type: SpeciesReference
stoichiometry: 1.0
species: 302657

014400
type: SpeciesReference
stoichiometry: 1.0
species: 303314

304467
type: Reaction
product: 023341
name: orotidine-5'-phosphate decarboxylase
kinetic law: 023366
fast: false
notes: GENE_ASSOCIATION: Umps.1 SUBSYSTEM: Pyrimidine Biosynthesis EC Number: Confidence Level: AUTHORS:
reactant: 023316
reversible: false
product: 023353
reactant: 023329

023341
type: SpeciesReference
stoichiometry: 1.0
species: 302657

308835
type: LocalParameter
units: 006281
value: 0.0

308832
type: LocalParameter
units: 006281
value: 0.0

308829
type: LocalParameter
units: 006281
value: 1000.0

308826
type: LocalParameter
units: 006281
value: 0.0

023316
type: SpeciesReference
stoichiometry: 1.0
species: 302819

023353
type: SpeciesReference
stoichiometry: 1.0
species: 303227

023329
type: SpeciesReference
stoichiometry: 1.0
species: 302987

303935
type: Reaction
kinetic law: 011991
product: 011979
product: 011967
reactant: 011955
notes: GENE_ASSOCIATION: Cat.1 SUBSYSTEM: ROS Detoxification EC Number: Confidence Level: AUTHORS:
fast: false
reversible: false
name: catalase

306701
type: LocalParameter
units: 006281
value: 0.0

306698
type: LocalParameter
units: 006281
value: 0.0

306695
type: LocalParameter
units: 006281
value: 1000.0

306692
type: LocalParameter
units: 006281
value: 0.0

011979
type: SpeciesReference
stoichiometry: 1.0
species: 302966

011967
type: SpeciesReference
stoichiometry: 2.0
species: 302822

011955
type: SpeciesReference
stoichiometry: 2.0
species: 302825

304874
type: Reaction
kinetic law: 032022
product: 032010
reactant: 031998
notes: GENE_ASSOCIATION: Slc29a1.1-e SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: uridine facilated transport in cytosol

310023
type: LocalParameter
units: 006281
value: 0.0

310021
type: LocalParameter
units: 006281
value: 0.0

310019
type: LocalParameter
units: 006281
value: 1000.0

310017
type: LocalParameter
units: 006281
value: -1000.0

032010
type: SpeciesReference
stoichiometry: 1.0
species: 303236

031998
type: SpeciesReference
stoichiometry: 1.0
species: 303482

303899
type: Reaction
kinetic law: 011191
product: 011179
reactant: 011167
notes: GENE_ASSOCIATION: SUBSYSTEM: Transport, Extracellular EC Number: Confidence Level: AUTHORS:
fast: false
reversible: true
name: L-ascorbate transport via facilitated diffusion

306557
type: LocalParameter
units: 006281
value: 0.0

306554
type: LocalParameter
units: 006281
value: 0.0

306551
type: LocalParameter
units: 006281
value: 1000.0

306548
type: LocalParameter
units: 006281
value: -1000.0

011179
type: SpeciesReference
stoichiometry: 1.0
species: 302586

011167
type: SpeciesReference
stoichiometry: 1.0
species: 303293

304641
type: Reaction
notes: GENE_ASSOCIATION: Pik4ca.1 or Pik4cb.1 or Pi4kii.1 SUBSYSTEM: Glycerophospholipid Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 027114
product: 027138
reversible: false
fast: false
name: phosphatidylinositol 4-kinase (C18:2,C16:0)
kinetic law: 027174
reactant: 027126
product: 027150
product: 027162

027114
type: SpeciesReference
stoichiometry: 1.0
species: 302589

027138
type: SpeciesReference
stoichiometry: 1.0
species: 302549

309399
type: LocalParameter
units: 006281
value: 0.0

309397
type: LocalParameter
units: 006281
value: 0.0

309395
type: LocalParameter
units: 006281
value: 1000.0

309393
type: LocalParameter
units: 006281
value: 0.0

027126
type: SpeciesReference
stoichiometry: 1.0
species: 303068

027150
type: SpeciesReference
stoichiometry: 1.0
species: 302819

027162
type: SpeciesReference
stoichiometry: 1.0
species: 303047

304614
type: Reaction
notes: GENE_ASSOCIATION: SUBSYSTEM: Inositol Phosphate Metabolism EC Number: Confidence Level: AUTHORS:
reactant: 026520
name: phosphatidylinositol-4-phosphate 4-phosphatase (C18:1,C18:1)
fast: false
product: 026532
kinetic law: 026556
product: 026544
reactant: 026507
reversible: false

026520
type: SpeciesReference
stoichiometry: 1.0
species: 303041

026532
type: SpeciesReference
stoichiometry: 1.0
species: 303062

309327
type: LocalParameter
units: 006281
value: 0.0

309325
type: LocalParameter
units: 006281
value: 0.0

309323
type: LocalParameter
units: 006281
value: 1000.0

309321
type: LocalParameter
units: 006281
value: 0.0

026544
type: SpeciesReference
stoichiometry: 1.0
species: 303131

026507
type: SpeciesReference
stoichiometry: 1.0
species: 302822

304155
type: Reaction
product: 016844
reactant: 016806
reactant: 016831
product: 016856
reactant: 016819
reversible: true
fast: false
name: galactose-1-phosphate uridylyltransferase
kinetic law: 016869
notes: GENE_ASSOCIATION: Galt.1 or Galt.3 or Galt.2 SUBSYSTEM: Galactose metabolism EC Number: Confidence Level: AUTHORS:

016844
type: SpeciesReference
stoichiometry: 1.0
species: 303143

016806
type: SpeciesReference
stoichiometry: 1.0
species: 302762

016831
type: SpeciesReference
stoichiometry: 1.0
species: 303239

016856
type: SpeciesReference
stoichiometry: 1.0
species: 303221

016819
type: SpeciesReference
stoichiometry: 1.0
species: 302819

307587
type: LocalParameter
units: 006281
value: 0.0

307584
type: LocalParameter
units: 006281
value: 0.0

307581
type: LocalParameter
units: 006281
value: 1000.0

307578
type: LocalParameter
units: 006281
value: -1000.0