MODEL1012220004
type: SBMLModel
reaction: 031639
reaction: 031546
species: 029493
reaction: 031821
reaction: 031528
reaction: 030762
reaction: 030590
species: 029338
reaction: 030866
species: 029837
reaction: 030600
reaction: 031748
reaction: 031739
species: 030096
species: 029751
reaction: 031167
reaction: 031575
species: 029130
reaction: 030828
species: 029907
reaction: 030571
species: 030193
species: 029527
reaction: 031040
species: 030293
species: 029044
reaction: 031261
species: 030240
reaction: 031757
name: Caron2010_mTORsignalingNetwork_ActivityFlow
species: 030147
reaction: 031510
species: 029372
reaction: 031473
reaction: 031214
species: 030505
reaction: 031903
reaction: 031721
compartment: 028614
species: 030417
species: 029233
species: 029665
reaction: 031885
reaction: 030962
species: 028975
species: 030364
reaction: 031666
species: 029182
reaction: 030895
species: 028855
species: 029579
reaction: 031360
reaction: 031288
species: 030301
compartment: 028648
species: 030284
species: 028716
species: 030470
species: 030010
reaction: 031333
reaction: 031279
reaction: 031315
species: 030027
reaction: 030991
species: 028769
reaction: 031078
reaction: 031126
species: 030408
reaction: 031612
species: 030320
species: 029924
reaction: 031417
species: 028872
species: 029061
reaction: 030630
species: 030231
species: 030275
reaction: 031195
reaction: 030905

031639
type: Reaction
product: 057680
reactant: 057668
fast: false
reversible: false

057680
type: SpeciesReference
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species: 030390

030390
type: Species
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name: S4

028665
type: Compartment
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name: Cell

057668
type: SpeciesReference
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species: 028975

028975
type: Species
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initial concentration: NaN
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name: PI4,5-P_sub_2

031546
type: Reaction
modifier: 057428
product: 057416
reactant: 057404
fast: false
reversible: false

030310
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: HIF-1_alpha

028614
type: Compartment
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size: 1.0
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name: Nucleus

057416
type: SpeciesReference
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species: 030328

030328
type: Species
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initial concentration: NaN
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in compartment: 028614
name: REDD1

057404
type: SpeciesReference
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species: 030337

030337
type: Species
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initial concentration: NaN
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name: REDD1

029493
type: Species
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initial concentration: NaN
initial amount: 0.0
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name: FoxO1/3_14-3-3

031821
type: Reaction
product: 058172
reactant: 058160
fast: false
reversible: false

058172
type: SpeciesReference
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species: 029510

029510
type: Species
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initial concentration: NaN
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name: S6K1

058160
type: SpeciesReference
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species: 029855

029855
type: Species
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: PP2A

031528
type: Reaction
product: 057368
reactant: 057356
fast: false
reversible: false

057368
type: SpeciesReference
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species: 030301

030301
type: Species
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: CCT_beta

057356
type: SpeciesReference
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species: 029510

030762
type: Reaction
product: 055315
reactant: 055303
fast: false
reversible: false

055315
type: SpeciesReference
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species: 029510

055303
type: SpeciesReference
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species: 029028

029028
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: 028682
name: mTORC1

028682
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: Lysosome

030590
type: Reaction
product: 054841
reactant: 054829
fast: false
reversible: false

054841
type: SpeciesReference
stoichiometry: 1.0
species: 029009

029009
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028631
name: TSC1/2

028631
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: Endomembrane

054829
type: SpeciesReference
stoichiometry: 1.0
species: 028872

028872
type: Species
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: ERK1/2

029338
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: PDCD4

030866
type: Reaction
product: 055579
reactant: 055567
fast: false
reversible: false

055579
type: SpeciesReference
stoichiometry: 1.0
species: 029390

029390
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
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name: S6

055567
type: SpeciesReference
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species: 029510

029837
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: FKBP12-rapamcyin

030600
type: Reaction
modifier: 054877
product: 054865
reactant: 054853
fast: false
reversible: false

028923
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: PI3K

054865
type: SpeciesReference
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species: 028992

028992
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: PI3,4,5-P_sub_3

054853
type: SpeciesReference
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species: 028975

031748
type: Reaction
product: 057968
reactant: 057956
fast: false
reversible: false

057968
type: SpeciesReference
stoichiometry: 1.0
species: 030417

030417
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: Apoptosis

057956
type: SpeciesReference
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species: 030425

030425
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028648
name: URI

028648
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: Mitochondria

031739
type: Reaction
product: 057944
reactant: 057932
fast: false
reversible: false

057944
type: SpeciesReference
stoichiometry: 1.0
species: 030425

057932
type: SpeciesReference
stoichiometry: 1.0
species: 029510

030096
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: FoxO1/3a

029751
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028682
name: GTP

031167
type: Reaction
product: 056385
reactant: 056373
fast: false
reversible: false

056385
type: SpeciesReference
stoichiometry: 1.0
species: 029028

056373
type: SpeciesReference
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species: 029562

029562
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: Torin

031575
type: Reaction
product: 057500
reactant: 057488
fast: false
reversible: false

057500
type: SpeciesReference
stoichiometry: 1.0
species: 030257

030257
type: Species
constant: false
boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: SGK1

057488
type: SpeciesReference
stoichiometry: 1.0
species: 028992

029130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: LKB1

030828
type: Reaction
product: 055483
reactant: 055471
fast: false
reversible: false

055483
type: SpeciesReference
stoichiometry: 1.0
species: 029372

029372
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: eEF2

055471
type: SpeciesReference
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species: 029355

029355
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: eEF2K

029907
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: Inflammation

030571
type: Reaction
product: 054793
reactant: 054781
fast: false
reversible: false

054793
type: SpeciesReference
stoichiometry: 1.0
species: 028889

028889
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
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name: RSK1/2

054781
type: SpeciesReference
stoichiometry: 1.0
species: 028872

030193
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: TSC2

029527
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: Autophagy

031040
type: Reaction
product: 056048
reactant: 056036
fast: false
reversible: false

056048
type: SpeciesReference
stoichiometry: 1.0
species: 029028

056036
type: SpeciesReference
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species: 029182

029182
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
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name: PML

030293
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
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name: SREBP1

029044
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: mTORC2

031261
type: Reaction
product: 056638
reactant: 056625
fast: false
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056638
type: SpeciesReference
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species: 029993

029993
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: Cytoskeletal_br_organization

056625
type: SpeciesReference
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species: 030372

030372
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: PKC_alpha

030240
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: p53

031757
type: Reaction
product: 057992
reactant: 057980
fast: false
reversible: false

057992
type: SpeciesReference
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species: 030434

030434
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: Mitochondrial_br_metabolism

057980
type: SpeciesReference
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species: 030443

030443
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: YY1-PGC1_alpha

030147
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: Cell cycle arrest_br_Growth arrest

031510
type: Reaction
product: 057320
reactant: 057308
fast: false
reversible: false

057320
type: SpeciesReference
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species: 029924

029924
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: Lipid synthesis

057308
type: SpeciesReference
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species: 030113

030113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: DNA

031473
type: Reaction
product: 057224
reactant: 057212
fast: false
reversible: false

057224
type: SpeciesReference
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species: 030222

030222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: UBF-TIF1A-SL1-PolI

057212
type: SpeciesReference
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species: 029510

031214
type: Reaction
product: 056509
reactant: 056497
fast: false
reversible: false

056509
type: SpeciesReference
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species: 030257

056497
type: SpeciesReference
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species: 029044

030505
type: Species
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has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: CI-1040

031903
type: Reaction
product: 058388
reactant: 058376
fast: false
reversible: false

058388
type: SpeciesReference
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species: 028855

028855
type: Species
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: MEK

058376
type: SpeciesReference
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species: 030505

031721
type: Reaction
product: 057896
reactant: 057884
fast: false
reversible: false

057896
type: SpeciesReference
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species: 030284

030284
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: Lipin-1

057884
type: SpeciesReference
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species: 029028

029233
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: 0.0
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name: SLC7A5

029665
type: Species
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initial concentration: NaN
initial amount: 0.0
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name: Rac1

031885
type: Reaction
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reactant: 058328
fast: false
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058340
type: SpeciesReference
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species: 030381

030381
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: Survival_br_Apoptosis

058328
type: SpeciesReference
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species: 030372

030962
type: Reaction
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product: 055831
reactant: 055819
fast: false
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055831
type: SpeciesReference
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species: 029786

029786
type: Species
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initial concentration: NaN
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name: Rheb

055819
type: SpeciesReference
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species: 030470

030470
type: Species
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initial concentration: NaN
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name: Rheb

030364
type: Species
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initial concentration: NaN
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name: Cell cycle

031666
type: Reaction
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057752
type: SpeciesReference
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species: 030478

030478
type: Species
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initial concentration: NaN
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name: FoxO1/3a

057740
type: SpeciesReference
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030275
type: Species
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initial concentration: NaN
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name: AKT

030895
type: Reaction
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reactant: 055639
fast: false
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055651
type: SpeciesReference
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species: 028906

028906
type: Species
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initial concentration: NaN
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name: IRS-1

055639
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species: 029510

029579
type: Species
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initial concentration: NaN
initial amount: 0.0
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name: ULK1-ATG13-FIP200

031360
type: Reaction
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fast: false
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056912
type: SpeciesReference
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056900
type: SpeciesReference
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031288
type: Reaction
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056716
type: SpeciesReference
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species: 029665

056703
type: SpeciesReference
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species: 029044

028716
type: Species
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initial concentration: NaN
initial amount: 0.0
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name: Insulin

028613
type: Compartment
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spatial dimensions: 3.0

030010
type: Species
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initial concentration: NaN
initial amount: 0.0
in compartment: 028613
name: Amino acids

031333
type: Reaction
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reactant: 056828
fast: false
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056840
type: SpeciesReference
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species: 030496

030496
type: Species
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initial concentration: NaN
initial amount: 0.0
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name: sa35_degraded

056828
type: SpeciesReference
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species: 029044

031279
type: Reaction
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reactant: 056677
fast: false
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056690
type: SpeciesReference
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species: 029648

029648
type: Species
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: RhoA

056677
type: SpeciesReference
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species: 029044

031315
type: Reaction
product: 056792
reactant: 056780
fast: false
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056792
type: SpeciesReference
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species: 029199

029199
type: Species
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initial concentration: NaN
initial amount: 0.0
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name: BNIP3

056780
type: SpeciesReference
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species: 029165

029165
type: Species
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has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028613
name: Hypoxia

030027
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028613
name: WNT signaling

030991
type: Reaction
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reactant: 055903
fast: false
reversible: false

055915
type: SpeciesReference
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species: 029700

029700
type: Species
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has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: I_kappa_B

055903
type: SpeciesReference
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species: 029683

029683
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: IKK_beta

028769
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: NF1

031078
type: Reaction
product: 056144
reactant: 056132
fast: false
reversible: false

056144
type: SpeciesReference
stoichiometry: 1.0
species: 029734

029734
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: mTORC1

056132
type: SpeciesReference
stoichiometry: 1.0
species: 029734

031126
type: Reaction
product: 056276
reactant: 056264
fast: false
reversible: false

056276
type: SpeciesReference
stoichiometry: 1.0
species: 029044

056264
type: SpeciesReference
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species: 029614

029614
type: Species
constant: false
boundary condition: false
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initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: PA

030408
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: Co-translational_br_protein folding

031612
type: Reaction
product: 057608
reactant: 057596
fast: false
reversible: false

057608
type: SpeciesReference
stoichiometry: 1.0
species: 030364

057596
type: SpeciesReference
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species: 030355

030355
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: p27

030320
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028614
name: Angiogenesis

031417
type: Reaction
product: 057080
reactant: 057068
fast: false
reversible: false

057080
type: SpeciesReference
stoichiometry: 1.0
species: 029009

057068
type: SpeciesReference
stoichiometry: 1.0
species: 030193

029061
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 028665
name: Frizzled

030630
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028959
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030231
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031195
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056459
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056447
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030905
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055675
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055663
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031454
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057176
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057164
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031436
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057128
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057116
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029958
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030552
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054745
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054733
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028837
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031427
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057104
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028941
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030203
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031106
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056228
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056216
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056204
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030514
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029147
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031657
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057728
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057716
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029079
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031849
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058244
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058232
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031146
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056337
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056325
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030461
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031306
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056768
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056755
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031186
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056434
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056422
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029596
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030753
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055291
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029286
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055279
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029269
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028751
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030914
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055699
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055687
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029889
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031020
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030213
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055988
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055976
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030973
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055867
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055855
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030668
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055057
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030266
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055045
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031388
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056984
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056972
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030543
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054721
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054709
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028786
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030810
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055435
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029321
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055423
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029407
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030838
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055507
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029459
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055495
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031445
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057152
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029941
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057140
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029096
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030061
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030487
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030130
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030885
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055627
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030452
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055615
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030248
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028734
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031177
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056409
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056397
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031730
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057920
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057908
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031693
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057824
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057812
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031675
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057776
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057764
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031242
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056586
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056573
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031464
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057200
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057188
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031702
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057848
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057836
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028699
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031001
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055940
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029717
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055928
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030724
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055218
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055189
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030715
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055177
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055165
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029768
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031379
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056960
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056948
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031068
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056120
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056108
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031059
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056096
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056084
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030772
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055339
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029303
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055327
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030523
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054661
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054649
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031556
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057452
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057440
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029441
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031794
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058100
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058088
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030734
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055243
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055231
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030649
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055009
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054997
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030044
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031766
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058016
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058004
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029803
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031519
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057344
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057332
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031117
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056252
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056240
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030876
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055603
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055591
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031088
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056168
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056156
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030943
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055771
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029251
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055759
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030610
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054901
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054889
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031621
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057632
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057620
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031584
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057524
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057512
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030781
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055363
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055351
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029424
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030399
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031030
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056024
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056012
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029476
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030800
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055411
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055399
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031830
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058196
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058184
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031858
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058268
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058256
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031537
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057392
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057380
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030658
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055033
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055021
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030933
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055747
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029545
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055735
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030182
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029872
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031775
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058040
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058028
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031369
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056936
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056924
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031252
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056612
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056599
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030857
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055555
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055543
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030078
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031482
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057248
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057236
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031097
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056192
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029820
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056180
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030677
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055081
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055069
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029631
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029113
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031049
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056072
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056060
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030952
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055795
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055783
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031894
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058364
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058352
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031712
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057872
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057860
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031876
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058316
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058304
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031867
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058292
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058280
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031397
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057008
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056996
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030165
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031784
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058076
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058064
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058052
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029216
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031351
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056888
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056876
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031297
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056742
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056729
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031156
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056361
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056349
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031342
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056864
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056852
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031324
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056816
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056804
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030639
type: Reaction
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054985
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054973
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030533
type: Reaction
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054685
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054673
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031803
type: Reaction
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058124
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058112
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029975
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030982
type: Reaction
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055891
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055879
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030924
type: Reaction
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055723
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055711
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030743
type: Reaction
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055267
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055255
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031136
type: Reaction
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056313
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056301
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056289
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031233
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056560
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056547
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031205
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056484
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056472
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030581
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054817
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054805
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030686
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055105
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055093
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030696
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055129
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055117
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031630
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057656
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057644
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031593
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057560
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057548
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031603
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057584
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057572
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030791
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055387
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055375
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031648
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057704
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057692
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031407
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057044
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057032
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031565
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057476
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057464
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028820
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030620
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054937
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054925
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031840
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058220
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058208
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031270
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056664
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056651
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031812
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058148
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058136
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031491
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057272
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057260
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031500
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057296
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057284
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031684
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057800
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057788
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031224
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056534
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056522
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030562
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054769
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054757
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030705
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055153
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055141
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031010
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055964
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055952
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030847
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055531
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055519
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030819
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055459
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055447
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028803
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