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notes: PMID: 12080070 PMID: 16954220 Since HSP70 has been shown to interact with PKCbetaII, we hypothesized that it might also be the case for PKCalpha.
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925286
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932213
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925328
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012876
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925656
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925175
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931630
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007034
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007022
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928240
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notes: PMID: 16919458
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928071
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932609
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925571
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024126
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930597
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024114
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936264
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reactant: 015349
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015373
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015361
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925664
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015349
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927442
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933790
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product: 006076
reactant: 006064
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006076
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928307
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006064
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938590
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product: 024210
reactant: 024198
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reversible: false

024210
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925563
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024198
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925520
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931325
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938953
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notes: PMID: 10453354
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025577
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927918
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926449
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notes: PMID: 15851026 PMID: 17671177 PMID: 15757502
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934059
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notes: PMID: 14970221
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007118
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932331
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937255
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notes: PMID: 10837071
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019157
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933235
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928012
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notes: PMID: 10635329
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027246
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931538
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017104
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024066
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024054
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927740
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023862
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023850
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927060
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008078
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925209
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026669
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936162
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reactant: 014965
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014989
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931612
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014977
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927433
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931593
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938324
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reactant: 023226
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023238
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928553
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023226
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928545
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023214
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927664
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931986
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938232
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reactant: 022854
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022878
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022866
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928758
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928511
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939118
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026237
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930356
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026225
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928818
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937734
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020896
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925587
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name: AKT_PIP_sub_3

020883
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937847
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product: 021342
reactant: 021330
notes: PMID: 18030348
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021354
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021342
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021330
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932709
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name: mTORC2-PPR5L

937188
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reactant: 018881
reactant: 018868
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fast: false
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018893
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930909
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name: TNF_alpha_-TRADD-RIP1-TRAF-E2Ub-IKK

018881
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930901
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notes: PMID: 19302050 PMID:
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initial amount: 0.0
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name: TNF_alpha_-TNFR-TRADD-RIP1-TRAF-E2Ub

018868
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006866
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name: PLD1

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name: GTP

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name: Bnip3

931810
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name: c-myc

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935231
type: Reaction
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reactant: 011509
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011521
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011509
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925445
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name: 5'cap-eIF4F-eIF3-eIF4B-PABP

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name: p53

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reactant: 017944
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933076
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name: rDNA-UBF-Pol1-TIF1B-TIF1A

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933060
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name: rDNA

017932
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939722
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fast: false
reactant: 028631
modifier: 028679
notes: PMID: 18391970 PMID: 17711846
modifier: 028667
product: 028643

028631
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927672
type: Species
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name: Gadd45

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name: FoxO1/3a

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name: Raptor

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product: 025541
reactant: 025529
notes: PMID: 10453354
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025541
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name: IL-1

025529
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type: Species
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934491
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reactant: 008630
notes: PMID: 10558990 PMID: 14504289 PMID: 10679322 PMID: 16213824
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008642
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929656
type: Species
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name: Proliferation_br_survival/apoptosis

008630
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926051
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name: CBC-mRNPs

940341
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030929
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030917
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name: EGFR

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021474
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species: 932601

021462
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species: 932280

021450
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reactant: 006602
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006614
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species: 930631

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type: Species
notes: Originally identified as a MKKK that acts upstream of members of the stress-activated MAP kinase family
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name: IRS-1

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species: 928887

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name: sa2107_degraded

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notes: PMID: 16043512 Cell lines: MEF, HEK293
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name: Nutrients

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931381
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name: ULK1/2-ATG13

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name: FoxO1/3a_14-3-3

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notes: PMID: 16286006 PMID: 19339977
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name: AMPK-related kinases

940155
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934924
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reactant: 010347
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010371
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species: 932029

010359
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species: 931986

010347
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species: 926457

926457
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name: Calmodulin_Ca_sub_2+

940655
type: Reaction
product: 031949
reactant: 031937
fast: false
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031949
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018340
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022266
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022254
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030785
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931157
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notes: PMID: 18439897 It remains to be shown whether SF2/ASF interacts with mTOR alone, with other members of the mTORC1 complex or represent a distinct new complex.
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notes: To date, no functional effect of these three phosphorylation sites has been reported. Since rapamycin prevents the serum-induced phosphorylation of these residues, we decided to illustrate the phosphorylated form of eIF4G in the translation initiation complex.
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notes: TCTP: PMID: 17301792 Shown in Drosophila DOCK7: PMID: 15963462 Cell line: HEK293
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notes: PMID: 17658474 Cell lines: HEK293, HeLa, NIH3T3
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031865
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notes: PMID: 17936702 PMID: 11493700
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940006
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notes: PMID: 15866171 PMID: 15928081 PMID: 11430832

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027330
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027318
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notes: PMID: 7537852
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025649
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reactant: 012564
notes: PMID: 15314020 PMID: 14560958 Individual contributions of 4EBP-1 P-sites to the control of eIF4E binding is controversial: PMID: 15767663 PMID: 12588975 PMID: 14507920
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020201
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notes: PMID: 17658474 Cell lines: HEK293, HeLa, NIH3T3
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014365
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017656
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940230
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notes: PMID: 11751382 human colon cancer
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notes: PMID: 16862180
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934109
type: Reaction
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notes: PMID: 1496022 PMID: 10567431 PMID: 9271440 PMID: 11914378 The analogous residues in mouse S6K1L are S394, S434, S441, T444 and S447.
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notes: PMID: 11029006 PMID: 11029007 PMID: 11029008 PMID: 19536106
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notes: A.E7 Th1 cells HEK293 cells PMID: 16428328 PMID: 19586661
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013032
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937508
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notes: PMID: 19446321
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reactant: 022614
notes: PMID: 14970194 Cell line: PC-12
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937472
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notes: PMID: 17936702 PMID: 11493700
fast: false
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notes: PMID: 15024086
fast: false
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fast: false
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notes: PMID: 14607085 PMID: 16244323
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notes: PMID: 17273797 Cell lines: HEK293, MEF
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930572
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notes: PMID: 19383975 (Review) PMID: 19402821 PMID: 19150980 PMID: 19209957 PMID: 18606717 PMID: 18721898 PMID: 16647110
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935358
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notes: PMID: 16043512 Cell lines: MEF, HEK293
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012048
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notes: PMID: 14731402 PMID: 19536106
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940663
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notes: PMID: 15504954 PMID: 19593385 cell line: 3T3-L1 pre-adipocytes
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937205
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notes: PMID: 19295631
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018953
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notes: PMID: 15854902 PMID: 17991864
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notes: PMID: 12582162
fast: false
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notes: PMID: 15808505
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940064
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029885
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product: 027511
product: 027499
reactant: 027487
notes: PMID: 19114562
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notes: PMID: 18650496 PMID: 15383653
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937669
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product: 020648
reactant: 020636
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notes: PMID: 19446321 Loss-of-function data indicate that within cells DEPTOR is an inhibitor of mTORC1 and mTORC2 activities. However, DEPTOR overexpression led to an apparent increase instead of inhibition of mTORC2 signaling as monitored by Akt S473 phosphorylation (Figure 5C and S4). The authors propose that the effects of DEPTOR overexpression on the mTOR pathway-inhibition of mTORC1 signaling but apparent activation of mTORC2 signaling-result from DEPTOR-mediated inhibition of mTORC1, which then leads to the hyperactivation of PI3K that would overcome the direct inhibitory effects of DEPTOR on mTORC2.
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notes: PMID: 14615539 PMID: 17041624
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name: EphB/ephrin-B

934812
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notes: PMID: 16624425
fast: false
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009891
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notes: PMID: 18439897
fast: false
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fast: false
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005733
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initial concentration: NaN
initial amount: 0.0
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name: PRAS40_14-3-3

005721
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940524
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reactant: 031565
fast: false
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031577
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031565
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939828
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notes: PMID: 18391970
fast: false
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name: AgRP

936843
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product: 017548
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notes: PMID: 11698641
fast: false
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937309
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940221
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937400
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940249
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937578
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940396
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937642
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937997
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937651
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940351
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939933
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940673
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937299
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936083
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020833
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020821
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933781
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933810
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006150
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006138
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934903
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010275
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010263
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935476
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012504
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933603
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005349
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940212
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030425
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030413
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934688
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939055
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934473
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935368
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938015
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940323
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030857
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938223
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022830
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940478
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934277
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007874
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933690
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938159
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940165
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937660
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940646
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939785
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936053
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933820
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935640
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