MODEL1011080002
type: SBMLModel
reaction: 207663
reaction: 207725
species: 207489
species: 207393
species: 207503
species: 207402
species: 207322
reaction: 207636
species: 207297
reaction: 207780
reaction: 207580
reaction: 207630
species: 207302
species: 207285
species: 207290
reaction: 207644
reaction: 207710
species: 207566
reaction: 207590
species: 207358
species: 207363
species: 207563
reaction: 207655
reaction: 207669
length unit: length
species: 207262
species: 207543
species: 207344
species: 207255
reaction: 207831
reaction: 207658
species: 207438
species: 207536
reaction: 207724
reaction: 207689
species: 207235
species: 207435
species: 207440
reaction: 207774
reaction: 207838
species: 207499
species: 207492
reaction: 207739
reaction: 207771
species: 207485
species: 207298
reaction: 207766
reaction: 207693
reaction: 207616
time units: time
species: 207312
species: 207384
species: 207295
species: 207307
reaction: 207701
species: 207359
species: 207462
reaction: 207796
reaction: 207733
reaction: 207690
species: 207562
reaction: 207601
reaction: 207820
reaction: 207620
species: 207354
reaction: 207678
species: 207537
species: 207448
reaction: 207758
reaction: 207763
reaction: 207608
species: 207334
reaction: 207800
species: 207329
reaction: 207631
reaction: 207704
reaction: 207790
reaction: 207818
reaction: 207640

207663
type: Reaction
product: 247969
product: 247957
reactant: 247945
reactant: 247933
notes: GENE_ASSOCIATION: ( BCI_0110_gmk ) PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase ) PROTEIN_CLASS: 2.7.4.8 SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Guanylate kinase

247969
type: SpeciesReference
stoichiometry: 1.0
species: 207384

207384
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: GDP

207233
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

247957
type: SpeciesReference
stoichiometry: 1.0
species: 207243

207243
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: ADP

247945
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207238
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: ATP

247933
type: SpeciesReference
stoichiometry: 1.0
species: 207373

207373
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: GMP

207725
type: Reaction
product: 250330
product: 250318
reactant: 250306
notes: GENE_ASSOCIATION: ( BCI_0183_dfp ) PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase ) PROTEIN_CLASS: 4.1.1.36 SUBSYSTEM: coenzyme A biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphopantothenoylcysteine decarboxylase

250330
type: SpeciesReference
stoichiometry: 1.0
species: 207359

207359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: CO2

250318
type: SpeciesReference
stoichiometry: 1.0
species: 207467

207467
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pantetheine 4'-phosphate

250306
type: SpeciesReference
stoichiometry: 1.0
species: 207465

207465
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: R-4'-phosphopantothenoyl-L-cysteine

207489
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: sirohydrochlorin

207393
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate

207503
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-keto-isovalerate

207402
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: homoserine

207322
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pyridoxamine 5'-phosphate

207636
type: Reaction
product: 246749
reactant: 246737
notes: GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis II GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

246749
type: SpeciesReference
stoichiometry: 1.0
species: 207538

207538
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: biotin

246737
type: SpeciesReference
stoichiometry: 1.0
species: 207545

207545
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 9-mercaptodethiobiotin

207297
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-heptaprenyl diphosphate

207780
type: Reaction
product: 252589
product: 252577
reactant: 252565
reactant: 252553
notes: GENE_ASSOCIATION: ( BCI_0082_pdxH ) PROTEIN_ASSOCIATION: ( Pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (PNPOx)//PMPOXI-RXN//PNPOXI-RXN ) PROTEIN_CLASS: 1.4.3.5 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: pyridoxal 5'-phosphate salvage pathway SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

252589
type: SpeciesReference
stoichiometry: 1.0
species: 207324

207324
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: H2O2

252577
type: SpeciesReference
stoichiometry: 1.0
species: 207325

207325
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pyridoxal 5'-phosphate

252565
type: SpeciesReference
stoichiometry: 1.0
species: 207377

207377
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pyridoxine-5'-phosphate

252553
type: SpeciesReference
stoichiometry: 1.0
species: 207323

207323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: oxygen

207580
type: Reaction
product: 244392
product: 244380
reactant: 244368
reactant: 244356
notes: GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 1.5.1.5 SUBSYSTEM: reductive acetyl coenzyme A pathway SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway) SUBSYSTEM: folate transformations SIDE: NADP SIDE: NADPH COFACTOR: NADP COFACTOR: NADPH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Methylenetetrahydrofolate dehydrogenase (NADP+)

244392
type: SpeciesReference
stoichiometry: 1.0
species: 207350

207350
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5,10-methenyltetrahydrofolate

244380
type: SpeciesReference
stoichiometry: 1.0
species: 207274

207274
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NADPH

244368
type: SpeciesReference
stoichiometry: 1.0
species: 207275

207275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NADP+

244356
type: SpeciesReference
stoichiometry: 1.0
species: 207389

207389
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5,10-methylene-THF

207630
type: Reaction
product: 246495
product: 246483
reactant: 246471
reactant: 246458
notes: GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 2.1.1.107 SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation) SUBSYSTEM: siroheme biosynthesis SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion) SIDE: S__45__ADENOSYLMETHIONINE SIDE: ADENOSYL__45__HOMO__45__CYS COFACTOR: S__45__ADENOSYLMETHIONINE COFACTOR: ADENOSYL__45__HOMO__45__CYS GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Uroporphyrinogen-III C-methyltransferase

246495
type: SpeciesReference
stoichiometry: 1.0
species: 207547

207547
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: precorrin-2

246483
type: SpeciesReference
stoichiometry: 1.0
species: 207442

207442
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: S-adenosyl-L-homocysteine

246471
type: SpeciesReference
stoichiometry: 1.0
species: 207530

207530
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: precorrin-1

246458
type: SpeciesReference
stoichiometry: 1.0
species: 207460

207460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: S-adenosyl-L-methionine

207302
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate

207285
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: sn-glycerol-3-phosphate

207290
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: cystathionine

207644
type: Reaction
product: 247071
product: 247059
reactant: 247047
reactant: 247034
notes: GENE_ASSOCIATION: ( BCI_0068_cysK ) PROTEIN_ASSOCIATION: ( cysteine synthase A ) PROTEIN_CLASS: 2.5.1.47 SUBSYSTEM: superpathway of cysteine biosynthesis SUBSYSTEM: cysteine biosynthesis I SIDE: ACET GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Cysteine synthase

247071
type: SpeciesReference
stoichiometry: 1.0
species: 207417

207417
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-cysteine

247059
type: SpeciesReference
stoichiometry: 1.0
species: 207439

207439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: acetate

247047
type: SpeciesReference
stoichiometry: 1.0
species: 207532

207532
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: O-acetyl-L-serine

247034
type: SpeciesReference
stoichiometry: 1.0
species: 207277

207277
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: hydrogen sulfide

207710
type: Reaction
product: 249774
reactant: 249762
notes: GENE_ASSOCIATION: ( BCI_0169_tpiA ) PROTEIN_ASSOCIATION: ( Triosephosphate isomerase (TIM) (Triose-phosphate isomerase)//TRIOSEPISOMERIZATION-RXN//Triose-phosphate isomerase ) PROTEIN_CLASS: 5.3.1.1 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Triosephosphate isomerase

249774
type: SpeciesReference
stoichiometry: 1.0
species: 207352

207352
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dihydroxy-acetone phosphate

249762
type: SpeciesReference
stoichiometry: 1.0
species: 207249

207249
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glyceraldehyde-3-phosphate

207566
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-hydroxybenzyl alcohol

207590
type: Reaction
product: 244778
product: 244766
reactant: 244754
reactant: 244742
notes: GENE_ASSOCIATION: ( BCI_0076_talB ) PROTEIN_ASSOCIATION: ( transaldolase A ) PROTEIN_CLASS: 2.2.1.2 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Transaldolase

244778
type: SpeciesReference
stoichiometry: 1.0
species: 207387

207387
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-erythrose-4-phosphate

244766
type: SpeciesReference
stoichiometry: 1.0
species: 207379

207379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: fructose-6-phosphate

244754
type: SpeciesReference
stoichiometry: 1.0
species: 207343

207343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-sedoheptulose-7-phosphate

244742
type: SpeciesReference
stoichiometry: 1.0
species: 207249

207358
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 6-phospho-D-gluconate

207363
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: &beta;-alanine

207563
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a ThiS-ThiF acyl-disulfide

207655
type: Reaction
product: 247558
reversible: false
name: Phosphogluconate dehydrogenase (decarboxylating)
product: 247546
reactant: 247534
product: 247570
reactant: 247522
fast: false
notes: GENE_ASSOCIATION: ( BCI_0397_gnd ) PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase, decarboxylating//6PGLUCONDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.44 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: NAD__45__P__45__OR__45__NOP SIDE: CARBON__45__DIOXIDE SIDE: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false

247558
type: SpeciesReference
stoichiometry: 1.0
species: 207268

207268
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NAD(P)H

247546
type: SpeciesReference
stoichiometry: 1.0
species: 207359

247534
type: SpeciesReference
stoichiometry: 1.0
species: 207358

247570
type: SpeciesReference
stoichiometry: 1.0
species: 207360

207360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-ribulose-5-phosphate

247522
type: SpeciesReference
stoichiometry: 1.0
species: 207270

207270
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NAD(P)+

207669
type: Reaction
product: 248188
product: 248176
reactant: 248164
reactant: 248152
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: purine nucleotides de novo biosynthesis I COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

248188
type: SpeciesReference
stoichiometry: 1.0
species: 207243

248176
type: SpeciesReference
stoichiometry: 1.0
species: 207525

207525
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dGTP

248164
type: SpeciesReference
stoichiometry: 1.0
species: 207238

248152
type: SpeciesReference
stoichiometry: 1.0
species: 207347

207347
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dGDP

207262
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a protein dithiol

207543
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribosyl-ATP

207344
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-histidinol-phosphate

207255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 10-formyl-tetrahydrofolate

207831
type: Reaction
reactant: 254758
product: 254770
reactant: 254745
product: 254794
name: NA
notes: GENE_ASSOCIATION: ( BCI_0008_ispG ) PROTEIN_ASSOCIATION: ( 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase ) PROTEIN_CLASS: 1.17.4.3 SUBSYSTEM: methylerythritol phosphate pathway SIDE: __124__Protein__45__Dithiols__124__ SIDE: __124__Protein__45__Disulfides__124__ SIDE: WATER GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
product: 254782

254758
type: SpeciesReference
stoichiometry: 1.0
species: 207262

254770
type: SpeciesReference
stoichiometry: 1.0
species: 207263

207263
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a protein disulfide

254745
type: SpeciesReference
stoichiometry: 1.0
species: 207260

207260
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-C-methyl-D-erythritol-2,4-cyclodiphosphate

254794
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207265
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: H2O

254782
type: SpeciesReference
stoichiometry: 1.0
species: 207264

207264
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate

207658
type: Reaction
product: 247715
product: 247703
reactant: 247691
reactant: 247679
notes: GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 2.1.1.107 SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation) SUBSYSTEM: siroheme biosynthesis SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion) SIDE: S__45__ADENOSYLMETHIONINE SIDE: ADENOSYL__45__HOMO__45__CYS COFACTOR: S__45__ADENOSYLMETHIONINE COFACTOR: ADENOSYL__45__HOMO__45__CYS GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

247715
type: SpeciesReference
stoichiometry: 1.0
species: 207442

247703
type: SpeciesReference
stoichiometry: 1.0
species: 207530

247691
type: SpeciesReference
stoichiometry: 1.0
species: 207460

247679
type: SpeciesReference
stoichiometry: 1.0
species: 207413

207413
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: uroporphyrinogen-III

207438
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dTDP

207536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a sulfur donor

207724
type: Reaction
product: 250294
product: 250281
reactant: 250269
reactant: 250257
notes: GENE_ASSOCIATION: ( BCI_0549_pabA ) or ( BCI_0453_pabB ) PROTEIN_ASSOCIATION: ( Para-aminobenzoate synthase, glutamine amidotransferase component ) or ( para-aminobenzoate synthase, component I ) PROTEIN_CLASS: 6.3.5.8 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aminodeoxychorismate synthase

250294
type: SpeciesReference
stoichiometry: 1.0
species: 207273

207273
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-glutamate

250281
type: SpeciesReference
stoichiometry: 1.0
species: 207409

207409
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-amino-4-deoxychorismate

250269
type: SpeciesReference
stoichiometry: 1.0
species: 207468

207468
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: chorismate

250257
type: SpeciesReference
stoichiometry: 1.0
species: 207372

207372
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-glutamine

207689
type: Reaction
reversible: false
product: 248998
notes: GENE_ASSOCIATION: ( BCI_0230_panB ) PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) (KPHMT)//3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN//3-methyl-2-oxobutanoate hydroxymethyltransferase ) PROTEIN_CLASS: 2.1.2.11 SUBSYSTEM: pantothenate biosynthesis I SIDE: WATER SIDE: METHYLENE__45__THF SIDE: THF COFACTOR: METHYLENE__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
name: 3-methyl-2-oxobutanoate hydroxymethyltransferase
reactant: 248962
reactant: 248950
reactant: 248974
product: 248986
fast: false

248998
type: SpeciesReference
stoichiometry: 1.0
species: 207258

207258
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: tetrahydrofolate

248962
type: SpeciesReference
stoichiometry: 1.0
species: 207265

248950
type: SpeciesReference
stoichiometry: 1.0
species: 207503

248974
type: SpeciesReference
stoichiometry: 1.0
species: 207389

248986
type: SpeciesReference
stoichiometry: 1.0
species: 207504

207504
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-dehydropantoate

207235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-lysine

207435
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N-carbamoyl-L-aspartate

207440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: acetylphosphate

207774
type: Reaction
product: 252335
product: 252323
reactant: 252310
reactant: 252298
notes: GENE_ASSOCIATION: ( BCI_0601_ribD ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibD//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN ) PROTEIN_CLASS: 3.5.4.26 SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

252335
type: SpeciesReference
stoichiometry: 1.0
species: 207293

207293
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: ammonia

252323
type: SpeciesReference
stoichiometry: 1.0
species: 207394

207394
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-amino-6-(5'-phosphoribosylamino)uracil

252310
type: SpeciesReference
stoichiometry: 1.0
species: 207393

252298
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207838
type: Reaction
product: 255075
reactant: 255026
product: 255063
notes: GENE_ASSOCIATION: ( BCI_0518_murC ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramate--alanine ligase//UDP-NACMUR-ALA-LIG-RXN ) PROTEIN_CLASS: 6.3.2.8 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
name: UDP-N-acetylmuramate--alanine ligase
reversible: false
product: 255051
reactant: 255039
fast: false
reactant: 255014

255075
type: SpeciesReference
stoichiometry: 1.0
species: 207243

255026
type: SpeciesReference
stoichiometry: 1.0
species: 207238

255063
type: SpeciesReference
stoichiometry: 1.0
species: 207242

207242
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphate

255051
type: SpeciesReference
stoichiometry: 1.0
species: 207240

207240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetylmuramoyl-L-alanine

255039
type: SpeciesReference
stoichiometry: 1.0
species: 207239

207239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-alanine

255014
type: SpeciesReference
stoichiometry: 1.0
species: 207237

207237
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetylmuramate

207499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: menaquinone-8

207492
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: riboflavin

207739
type: Reaction
product: 250919
product: 250907
reactant: 250895
reactant: 250883
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

250919
type: SpeciesReference
stoichiometry: 1.0
species: 207390

207390
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dUTP

250907
type: SpeciesReference
stoichiometry: 1.0
species: 207243

250895
type: SpeciesReference
stoichiometry: 1.0
species: 207450

207450
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dUDP

250883
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207771
type: Reaction
product: 252226
product: 252214
reactant: 252201
reactant: 252189
notes: GENE_ASSOCIATION: ( BCI_0020_plsB ) PROTEIN_ASSOCIATION: ( glycerol-3-phosphate acyltransferase//GLYCEROL-3-P-ACYLTRANSFER-RXN ) PROTEIN_CLASS: 2.3.1.15 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SIDE: __124__Fatty__45__Acyl__45__CoA__124__ SIDE: CO__45__A COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__ COFACTOR: CO__45__A GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: NA

252226
type: SpeciesReference
stoichiometry: 1.0
species: 207310

207310
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: coenzyme A

252214
type: SpeciesReference
stoichiometry: 1.0
species: 207398

207398
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a 2-lysophosphatidate

252201
type: SpeciesReference
stoichiometry: 1.0
species: 207285

252189
type: SpeciesReference
stoichiometry: 1.0
species: 207397

207397
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a fatty acyl CoA

207485
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: acetyl-CoA

207298
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-octaprenyl diphosphate

207766
type: Reaction
product: 252032
product: 252019
reactant: 252007
reactant: 251995
notes: GENE_ASSOCIATION: ( BCI_0561_folA ) PROTEIN_ASSOCIATION: ( dihydrofolate reductase ) PROTEIN_CLASS: 1.5.1.3 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydrofolate reductase

252032
type: SpeciesReference
stoichiometry: 1.0
species: 207258

252019
type: SpeciesReference
stoichiometry: 1.0
species: 207275

252007
type: SpeciesReference
stoichiometry: 1.0
species: 207274

251995
type: SpeciesReference
stoichiometry: 1.0
species: 207407

207407
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-dihydrofolate

207693
type: Reaction
product: 249120
reactant: 249107
reactant: 249094
notes: GENE_ASSOCIATION: ( BCI_0244_pgl ) PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase ) PROTEIN_CLASS: 3.1.1.31 SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 6-phosphogluconolactonase

249120
type: SpeciesReference
stoichiometry: 1.0
species: 207358

249107
type: SpeciesReference
stoichiometry: 1.0
species: 207265

249094
type: SpeciesReference
stoichiometry: 1.0
species: 207470

207470
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glucono-&delta;-lactone-6-phosphate

207616
type: Reaction
product: 245902
product: 245890
reactant: 245878
notes: GENE_ASSOCIATION: ( BCI_0023_aroB ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate synthase ) PROTEIN_CLASS: 4.2.3.4 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-dehydroquinate synthase

245902
type: SpeciesReference
stoichiometry: 1.0
species: 207242

245890
type: SpeciesReference
stoichiometry: 1.0
species: 207552

207552
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3-dehydroquinate

245878
type: SpeciesReference
stoichiometry: 1.0
species: 207388

207388
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3-deoxy-D-arabino-heptulosonate-7-phosphate

207312
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: CTP

207295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-hexaprenyl diphosphate

207307
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: malate

207701
type: Reaction
product: 249411
product: 249399
reactant: 249387
reactant: 249374
notes: GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 4.99.1.4 SUBSYSTEM: siroheme biosynthesis SIDE: FE__43__2 SIDE: PROTON GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Sirohydrochlorin ferrochelatase

249411
type: SpeciesReference
stoichiometry: 1.0
species: 207490

207490
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: siroheme

249399
type: SpeciesReference
stoichiometry: 2.0
species: 207267

207267
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: H+

249387
type: SpeciesReference
stoichiometry: 1.0
species: 207489

249374
type: SpeciesReference
stoichiometry: 1.0
species: 207488

207488
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: Fe2+

207462
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-1-phosphatidyl-ethanolamine

207796
type: Reaction
product: 253300
product: 253288
reactant: 253276
reactant: 253264
notes: GENE_ASSOCIATION: ( BCI_0402_hisB ) PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase/histidinol phosphatase//HISTIDPHOS-RXN//IMIDPHOSDEHYD-RXN ) PROTEIN_CLASS: 3.1.3.15 SUBSYSTEM: histidine biosynthesis I SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Histidinol-phosphatase

253300
type: SpeciesReference
stoichiometry: 1.0
species: 207345

207345
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: histidinol

253288
type: SpeciesReference
stoichiometry: 1.0
species: 207242

253276
type: SpeciesReference
stoichiometry: 1.0
species: 207265

253264
type: SpeciesReference
stoichiometry: 1.0
species: 207344

207733
type: Reaction
product: 250690
product: 250678
reactant: 250666
notes: GENE_ASSOCIATION: ( BCI_0587_psd ) PROTEIN_ASSOCIATION: ( Phosphatidylserine decarboxylase proenzyme [Contains: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]//PHOSPHASERDECARB-RXN//Phosphatidylserine decarboxylase ) PROTEIN_CLASS: 4.1.1.65 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphatidylserine decarboxylase

250690
type: SpeciesReference
stoichiometry: 1.0
species: 207359

250678
type: SpeciesReference
stoichiometry: 1.0
species: 207462

250666
type: SpeciesReference
stoichiometry: 1.0
species: 207339

207339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-1-phosphatidylserine

207690
type: Reaction
product: 249034
reactant: 249022
reactant: 249010
notes: GENE_ASSOCIATION: ( BCI_0398_hisI ) PROTEIN_ASSOCIATION: ( phosphoribosyl-AMP cyclohydrolase//HISTCYCLOHYD-RXN ) PROTEIN_CLASS: 3.5.4.19 SUBSYSTEM: histidine biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosyl-AMP cyclohydrolase

249034
type: SpeciesReference
stoichiometry: 1.0
species: 207299

207299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribosylformiminoAICAR-phosphate

249022
type: SpeciesReference
stoichiometry: 1.0
species: 207265

249010
type: SpeciesReference
stoichiometry: 1.0
species: 207502

207502
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribosyl-AMP

207562
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an oxidized thioredoxin

207601
type: Reaction
product: 245251
product: 245239
reactant: 245227
reactant: 245215
notes: GENE_ASSOCIATION: ( BCI_0521_mraY ) PROTEIN_ASSOCIATION: ( phospho-N-acetylmuramoyl-pentapeptide- transferase//PHOSNACMURPENTATRANS-RXN ) PROTEIN_CLASS: 2.7.8.13 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: UNDECAPRENYL__45__P SIDE: UMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phospho-N-acetylmuramoyl-pentapeptide-transferase

245251
type: SpeciesReference
stoichiometry: 1.0
species: 207329

207329
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UMP

245239
type: SpeciesReference
stoichiometry: 1.0
species: 207424

207424
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol

245227
type: SpeciesReference
stoichiometry: 1.0
species: 207335

207335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate- D-alanyl-D-alanine

245215
type: SpeciesReference
stoichiometry: 1.0
species: 207327

207327
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: undecaprenyl phosphate

207820
type: Reaction
product: 254277
product: 254265
reactant: 254253
reactant: 254241
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

254277
type: SpeciesReference
stoichiometry: 1.0
species: 207280

207280
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: diphosphate

254265
type: SpeciesReference
stoichiometry: 1.0
species: 207298

254253
type: SpeciesReference
stoichiometry: 1.0
species: 207297

254241
type: SpeciesReference
stoichiometry: 1.0
species: 207294

207294
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: isopentenyl diphosphate

207620
type: Reaction
product: 246059
product: 246047
reactant: 246035
reactant: 246023
notes: GENE_ASSOCIATION: ( BCI_0604_thiL ) PROTEIN_ASSOCIATION: ( thiamine monophosphate kinase//THI-P-KIN-RXN ) PROTEIN_CLASS: 2.7.4.16 SUBSYSTEM: thiamine biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Thiamine-phosphate kinase

246059
type: SpeciesReference
stoichiometry: 1.0
species: 207550

207550
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: thiamine diphosphate

246047
type: SpeciesReference
stoichiometry: 1.0
species: 207243

246035
type: SpeciesReference
stoichiometry: 1.0
species: 207495

207495
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: thiamine-phosphate

246023
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207354
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: shikimate-3-phosphate

207678
type: Reaction
reactant: 248468
product: 248504
reactant: 248455
name: NA
fast: false
reversible: false
reactant: 248480
product: 248516
notes: GENE_ASSOCIATION: ( BCI_0558_ispH ) PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN ) PROTEIN_CLASS: 1.17.1.2 SUBSYSTEM: methylerythritol phosphate pathway SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP SIDE: WATER COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
product: 248492

248468
type: SpeciesReference
stoichiometry: 1.0
species: 207267

248504
type: SpeciesReference
stoichiometry: 1.0
species: 207270

248455
type: SpeciesReference
stoichiometry: 1.0
species: 207264

248480
type: SpeciesReference
stoichiometry: 1.0
species: 207268

248516
type: SpeciesReference
stoichiometry: 1.0
species: 207265

248492
type: SpeciesReference
stoichiometry: 1.0
species: 207294

207537
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an unsulfurated sulfur acceptor

207448
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: (2S)-2-amino-3-oxo-4-phosphonooxybutanoate

207758
type: Reaction
fast: false
reactant: 251636
product: 251684
notes: GENE_ASSOCIATION: ( BCI_0270_cyoE ) PROTEIN_ASSOCIATION: ( protoheme IX farnesyltransferase ) PROTEIN_CLASS: 2.5.1.- GENERIC: false TYPE: small HOLE: false
product: 251672
name: heme o biosynthesis
reactant: 251648
reactant: 251660
reversible: true

251636
type: SpeciesReference
stoichiometry: 1.0
species: 207369

207369
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: (E,E)-farnesyl diphosphate

251684
type: SpeciesReference
stoichiometry: 1.0
species: 207420

207420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: heme o

251672
type: SpeciesReference
stoichiometry: 1.0
species: 207280

251648
type: SpeciesReference
stoichiometry: 1.0
species: 207265

251660
type: SpeciesReference
stoichiometry: 1.0
species: 207419

207419
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: protoheme IX

207763
type: Reaction
product: 251896
product: 251884
reactant: 251872
notes: GENE_ASSOCIATION: ( BCI_0062_hemD ) PROTEIN_ASSOCIATION: ( uroporphyrinogen-III synthase ) PROTEIN_CLASS: 4.2.1.75 SUBSYSTEM: tetrapyrrole biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: uroporphyrinogen-III synthase

251896
type: SpeciesReference
stoichiometry: 1.0
species: 207413

251884
type: SpeciesReference
stoichiometry: 1.0
species: 207265

251872
type: SpeciesReference
stoichiometry: 1.0
species: 207412

207412
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: hydroxymethylbilane

207608
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0300_ribA ) PROTEIN_ASSOCIATION: ( GTP cyclohydrolase II ) PROTEIN_CLASS: 3.5.4.25 SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: FORMATE SIDE: PPI GENERIC: false TYPE: small HOLE: false
product: 245540
fast: false
reactant: 245504
reactant: 245492
product: 245516
name: GTP cyclohydrolase II
product: 245528
reversible: false

245540
type: SpeciesReference
stoichiometry: 1.0
species: 207280

245504
type: SpeciesReference
stoichiometry: 3.0
species: 207265

245492
type: SpeciesReference
stoichiometry: 1.0
species: 207380

207380
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: GTP

245516
type: SpeciesReference
stoichiometry: 1.0
species: 207393

245528
type: SpeciesReference
stoichiometry: 1.0
species: 207328

207328
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: formate

207334
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: PPPi

207800
type: Reaction
product: 253444
product: 253432
reactant: 253420
reactant: 253408
notes: GENE_ASSOCIATION: ( BCI_0025_pssA ) PROTEIN_ASSOCIATION: ( phosphatidylserine synthase//PHOSPHASERSYN-RXN ) PROTEIN_CLASS: 2.7.8.8 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis SIDE: SER SIDE: CMP GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: CDP-diacylglycerol--serine O-phosphatidyltransferase

253444
type: SpeciesReference
stoichiometry: 1.0
species: 207339

253432
type: SpeciesReference
stoichiometry: 1.0
species: 207288

207288
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: CMP

253420
type: SpeciesReference
stoichiometry: 1.0
species: 207338

207338
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-serine

253408
type: SpeciesReference
stoichiometry: 1.0
species: 207284

207284
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a CDP-diacylglycerol

207631
type: Reaction
product: 246543
product: 246531
reactant: 246519
reactant: 246507
notes: GENE_ASSOCIATION: ( BCI_0649_thiD ) PROTEIN_ASSOCIATION: ( phosphomethylpyrimidine kinase ) PROTEIN_CLASS: 2.7.4.7 SUBSYSTEM: thiamine biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphomethylpyrimidine kinase

246543
type: SpeciesReference
stoichiometry: 1.0
species: 207243

246531
type: SpeciesReference
stoichiometry: 1.0
species: 207493

207493
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine-pyrophosphate

246519
type: SpeciesReference
stoichiometry: 1.0
species: 207378

207378
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: hydroxymethylpyrimidine phosphate

246507
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207704
type: Reaction
product: 249519
product: 249507
reactant: 249495
reactant: 249483
notes: GENE_ASSOCIATION: ( BCI_0383_pta ) PROTEIN_ASSOCIATION: ( phosphate acetyltransferase//PHOSACETYLTRANS-RXN ) PROTEIN_CLASS: 2.3.1.8 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: sulfoacetaldehyde degradation SUBSYSTEM: acetate formation from acetyl-CoA I SUBSYSTEM: pyruvate fermentation to acetate II SUBSYSTEM: pyruvate fermentation to acetate IV SIDE: __124__Pi__124__ SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phosphate acetyltransferase

249519
type: SpeciesReference
stoichiometry: 1.0
species: 207440

249507
type: SpeciesReference
stoichiometry: 1.0
species: 207310

249495
type: SpeciesReference
stoichiometry: 1.0
species: 207485

249483
type: SpeciesReference
stoichiometry: 1.0
species: 207242

207790
type: Reaction
product: 253046
reversible: false
reactant: 253022
product: 253058
product: 253070
reactant: 253034
name: NA
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: folate polyglutamylation II SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
fast: false
reactant: 253009

253046
type: SpeciesReference
stoichiometry: 1.0
species: 207243

253022
type: SpeciesReference
stoichiometry: 1.0
species: 207273

253058
type: SpeciesReference
stoichiometry: 1.0
species: 207242

253070
type: SpeciesReference
stoichiometry: 1.0
species: 207355

207355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a folylpolyglutamate(n)

253034
type: SpeciesReference
stoichiometry: 1.0
species: 207355

253009
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207818
type: Reaction
product: 254205
product: 254193
reactant: 254181
reactant: 254169
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

254205
type: SpeciesReference
stoichiometry: 1.0
species: 207303

207303
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-pentaprenyl diphosphate

254193
type: SpeciesReference
stoichiometry: 1.0
species: 207280

254181
type: SpeciesReference
stoichiometry: 1.0
species: 207294

254169
type: SpeciesReference
stoichiometry: 1.0
species: 207302

207640
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0249_bioD ) PROTEIN_ASSOCIATION: ( Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS)//DETHIOBIOTIN-SYN-RXN//Dethiobiotin synthase ) PROTEIN_CLASS: 6.3.3.3 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: ATP SIDE: CARBON__45__DIOXIDE SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
name: dethiobiotin synthetase
reactant: 246885
reversible: false
reactant: 246872
product: 246924
product: 246911
fast: false
product: 246937
reactant: 246898

246885
type: SpeciesReference
stoichiometry: 1.0
species: 207238

246872
type: SpeciesReference
stoichiometry: 1.0
species: 207541

207541
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-diaminopelargonate

246924
type: SpeciesReference
stoichiometry: 1.0
species: 207242

246911
type: SpeciesReference
stoichiometry: 1.0
species: 207243

246937
type: SpeciesReference
stoichiometry: 1.0
species: 207533

207533
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dethiobiotin

246898
type: SpeciesReference
stoichiometry: 1.0
species: 207359

207509
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribosyl-formamido-carboxamide

207429
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: FAD

207520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-tyrosine

207615
type: Reaction
fast: false
reactant: 245830
name: NA
product: 245842
product: 245866
reactant: 245818
reversible: false
product: 245854
notes: GENE_ASSOCIATION: ( BCI_0279_pdxJ ) PROTEIN_ASSOCIATION: ( pyridoxal phosphate biosynthetic protein PdxJ ) PROTEIN_CLASS: 2.6.99.2 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false

245830
type: SpeciesReference
stoichiometry: 1.0
species: 207422

207422
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 1-deoxy-D-xylulose 5-phosphate

245842
type: SpeciesReference
stoichiometry: 1.0
species: 207377

245866
type: SpeciesReference
stoichiometry: 1.0
species: 207242

245818
type: SpeciesReference
stoichiometry: 1.0
species: 207449

207449
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 1-amino-propan-2-one-3-phosphate

245854
type: SpeciesReference
stoichiometry: 2.0
species: 207265

207755
type: Reaction
product: 251576
product: 251564
reactant: 251552
reactant: 251540
notes: GENE_ASSOCIATION: ( BCI_0519_murG ) PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase ) PROTEIN_CLASS: 2.4.1.227 SUBSYSTEM: peptidoglycan biosynthesis I COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE COFACTOR: UDP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Undecaprenyldiphospho-muramoylpentapeptide &beta;-N- acetylglucosaminyltransferase

251576
type: SpeciesReference
stoichiometry: 1.0
species: 207427

207427
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine

251564
type: SpeciesReference
stoichiometry: 1.0
species: 207425

207425
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP

251552
type: SpeciesReference
stoichiometry: 1.0
species: 207424

251540
type: SpeciesReference
stoichiometry: 1.0
species: 207423

207423
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetyl-D-glucosamine

207665
type: Reaction
product: 248078
product: 248066
reactant: 248054
reactant: 248042
notes: GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: NA

248078
type: SpeciesReference
stoichiometry: 1.0
species: 207259

207259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pyruvate

248066
type: SpeciesReference
stoichiometry: 1.0
species: 207322

248054
type: SpeciesReference
stoichiometry: 1.0
species: 207325

248042
type: SpeciesReference
stoichiometry: 1.0
species: 207430

207430
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-alanine

207623
type: Reaction
name: L-aspartate oxidase
reactant: 246119
reversible: true
product: 246131
fast: false
product: 246155
product: 246143
reactant: 246095
notes: GENE_ASSOCIATION: ( BCI_0614_nadB ) PROTEIN_ASSOCIATION: ( L-aspartate oxidase ) PROTEIN_CLASS: 1.4.3.16 COFACTOR: L__45__ASPARTATE COFACTOR: OXALACETIC_ACID GENERIC: false TYPE: small HOLE: false
reactant: 246107

246119
type: SpeciesReference
stoichiometry: 1.0
species: 207265

246131
type: SpeciesReference
stoichiometry: 1.0
species: 207459

207459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: iminoaspartate

246155
type: SpeciesReference
stoichiometry: 1.0
species: 207324

246143
type: SpeciesReference
stoichiometry: 1.0
species: 207293

246095
type: SpeciesReference
stoichiometry: 1.0
species: 207323

246107
type: SpeciesReference
stoichiometry: 1.0
species: 207383

207383
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-aspartate

207313
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-phosphatidate

207500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: menaquinol

207483
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7-keto-8-aminopelargonate

207673
type: Reaction
product: 248298
reactant: 248285
reactant: 248273
notes: GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA SUBSYSTEM: formylTHF biosynthesis II SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

248298
type: SpeciesReference
stoichiometry: 1.0
species: 207478

207478
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-formyl-tetrahydrofolate

248285
type: SpeciesReference
stoichiometry: 1.0
species: 207265

248273
type: SpeciesReference
stoichiometry: 1.0
species: 207350

207596
type: Reaction
product: 245082
product: 245070
reactant: 245058
reactant: 245046
notes: GENE_ASSOCIATION: ( BCI_0252_serC ) PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase//PSERTRANSAM-RXN//PSERTRANSAMPYR-RXN ) PROTEIN_CLASS: 2.6.1.52 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

245082
type: SpeciesReference
stoichiometry: 1.0
species: 207317

207317
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-ketoglutarate

245070
type: SpeciesReference
stoichiometry: 1.0
species: 207553

207553
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-(phosphonooxy)-threonine

245058
type: SpeciesReference
stoichiometry: 1.0
species: 207273

245046
type: SpeciesReference
stoichiometry: 1.0
species: 207433

207433
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-oxo-3-hydroxy-4-phosphobutanoate

207289
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: CDP

207575
type: Reaction
product: 244164
reactant: 244152
fast: false
reversible: false
name: polymerisation

244164
type: SpeciesReference
stoichiometry: 1.0
species: 207335

244152
type: SpeciesReference
stoichiometry: 1.0
species: 207333

207333
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a UDP-N-acetylmuramoyl-pentapeptide

207269
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dimethylallyl-diphosphate

207560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-dihydropteroate

207593
type: Reaction
product: 244887
reversible: true
reactant: 244863
reactant: 244875
product: 244900
product: 244912
name: synthesis of p-aminobenzoic acid
fast: false
notes: GENE_ASSOCIATION: ( BCI_0549_pabA ) or ( BCI_0432_pabC ) or ( BCI_0453_pabB ) PROTEIN_ASSOCIATION: ( Para-aminobenzoate synthase, glutamine amidotransferase component ) or ( 4-amino-4-deoxychorismate lyase ) or ( para-aminobenzoate synthase, component I ) PROTEIN_CLASS: NA GENERIC: false TYPE: small HOLE: false

244887
type: SpeciesReference
stoichiometry: 1.0
species: 207410

207410
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: p-aminobenzoate

244863
type: SpeciesReference
stoichiometry: 1.0
species: 207372

244875
type: SpeciesReference
stoichiometry: 1.0
species: 207468

244900
type: SpeciesReference
stoichiometry: 1.0
species: 207273

244912
type: SpeciesReference
stoichiometry: 1.0
species: 207259

207808
type: Reaction
reactant: 253794
notes: GENE_ASSOCIATION: ( BCI_0036_purD ) PROTEIN_ASSOCIATION: ( phosphoribosylamine--glycine ligase ) PROTEIN_CLASS: 6.3.4.13 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: GLY SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
reactant: 253782
product: 253806
reversible: false
product: 253818
reactant: 253770
fast: false
product: 253830
name: Phosphoribosylamine--glycine ligase

253794
type: SpeciesReference
stoichiometry: 1.0
species: 207315

207315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-phospho-&beta;-D-ribosyl-amine

253782
type: SpeciesReference
stoichiometry: 1.0
species: 207238

253806
type: SpeciesReference
stoichiometry: 1.0
species: 207254

207254
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-phospho-ribosyl-glycineamide

253818
type: SpeciesReference
stoichiometry: 1.0
species: 207242

253770
type: SpeciesReference
stoichiometry: 1.0
species: 207314

207314
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: glycine

253830
type: SpeciesReference
stoichiometry: 1.0
species: 207243

207749
type: Reaction
product: 251305
product: 251293
reactant: 251281
reactant: 251269
notes: GENE_ASSOCIATION: ( BCI_0363_pdxB ) PROTEIN_ASSOCIATION: ( Erythronate-4-phosphate dehydrogenase//ERYTHRON4PDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.290 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

251305
type: SpeciesReference
stoichiometry: 1.0
species: 207433

251293
type: SpeciesReference
stoichiometry: 1.0
species: 207253

207253
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NADH

251281
type: SpeciesReference
stoichiometry: 1.0
species: 207250

207250
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: NAD+

251269
type: SpeciesReference
stoichiometry: 1.0
species: 207432

207432
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: erythronate-4-phosphate

207535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a sulfurated sulfur donor

207825
type: Reaction
product: 254481
product: 254469
reactant: 254457
reactant: 254445
notes: GENE_ASSOCIATION: ( BCI_0240_pgsA ) PROTEIN_ASSOCIATION: ( CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase ) PROTEIN_CLASS: 2.7.8.5 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: GLYCEROL__45__3P SIDE: CMP GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

254481
type: SpeciesReference
stoichiometry: 1.0
species: 207288

254469
type: SpeciesReference
stoichiometry: 1.0
species: 207287

207287
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-1-phosphatidylglycerol-phosphate

254457
type: SpeciesReference
stoichiometry: 1.0
species: 207285

254445
type: SpeciesReference
stoichiometry: 1.0
species: 207284

207528
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: acetaldehyde

207330
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a UDP-N-acetylmuramoyl-tripeptide

207649
type: Reaction
name: biotin synthase
product: 247278
product: 247266
product: 247254
reactant: 247206
reactant: 247230
notes: GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis I SIDE: S__45__ADENOSYLMETHIONINE SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__ SIDE: CPD__45__249 SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__ SIDE: MET SIDE: CH33ADO GENERIC: true TYPE: small HOLE: false
reactant: 247218
reversible: false
reactant: 247242
product: 247290
fast: false

247278
type: SpeciesReference
stoichiometry: 2.0
species: 207479

207479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-methionine

247266
type: SpeciesReference
stoichiometry: 1.0
species: 207538

247254
type: SpeciesReference
stoichiometry: 1.0
species: 207537

247206
type: SpeciesReference
stoichiometry: 2.0
species: 207460

247230
type: SpeciesReference
stoichiometry: 1.0
species: 207535

247218
type: SpeciesReference
stoichiometry: 1.0
species: 207533

247242
type: SpeciesReference
stoichiometry: 1.0
species: 207536

247290
type: SpeciesReference
stoichiometry: 2.0
species: 207480

207480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5'-deoxyadenosine

207654
type: Reaction
product: 247509
product: 247496
reactant: 247484
reactant: 247472
notes: GENE_ASSOCIATION: ( BCI_0645_pgk ) PROTEIN_ASSOCIATION: ( phosphoglycerate kinase ) PROTEIN_CLASS: 2.7.2.3 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phosphoglycerate kinase

247509
type: SpeciesReference
stoichiometry: 1.0
species: 207243

247496
type: SpeciesReference
stoichiometry: 1.0
species: 207252

207252
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 1,3-diphosphateglycerate

247484
type: SpeciesReference
stoichiometry: 1.0
species: 207238

247472
type: SpeciesReference
stoichiometry: 1.0
species: 207526

207526
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3-phosphoglycerate

207508
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 6,7-dimethyl-8-(1-D-ribityl)lumazine

207668
type: Reaction
product: 248140
reactant: 248127
notes: GENE_ASSOCIATION: ( BCI_0251_gpmA ) PROTEIN_ASSOCIATION: ( phosphoglycerate mutase ) PROTEIN_CLASS: 5.4.2.1 SUBSYSTEM: glycolysis I SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phosphoglycerate mutase

248140
type: SpeciesReference
stoichiometry: 1.0
species: 207348

207348
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-phosphoglycerate

248127
type: SpeciesReference
stoichiometry: 1.0
species: 207526

207734
type: Reaction
product: 250739
product: 250727
reactant: 250715
reactant: 250703
notes: GENE_ASSOCIATION: ( BCI_0614_nadB ) PROTEIN_ASSOCIATION: ( L-aspartate oxidase ) PROTEIN_CLASS: 1.4.3.- SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

250739
type: SpeciesReference
stoichiometry: 1.0
species: 207459

250727
type: SpeciesReference
stoichiometry: 1.0
species: 207324

250715
type: SpeciesReference
stoichiometry: 1.0
species: 207383

250703
type: SpeciesReference
stoichiometry: 1.0
species: 207323

207395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: oxaloacetate

207510
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-4'-phosphopantothenate

207505
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3,4-dihydroxy-2-butanone-4-P

207681
type: Reaction
product: 248685
product: 248673
reactant: 248661
reactant: 248649
notes: GENE_ASSOCIATION: ( BCI_0359_coaA ) PROTEIN_ASSOCIATION: ( pantothenate kinase ) PROTEIN_CLASS: 2.7.1.33 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Pantothenate kinase

248685
type: SpeciesReference
stoichiometry: 1.0
species: 207510

248673
type: SpeciesReference
stoichiometry: 1.0
species: 207243

248661
type: SpeciesReference
stoichiometry: 1.0
species: 207238

248649
type: SpeciesReference
stoichiometry: 1.0
species: 207364

207364
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pantothenate

207679
type: Reaction
product: 248564
product: 248552
reactant: 248540
reactant: 248528
notes: GENE_ASSOCIATION: ( BCI_0253_aroA ) PROTEIN_ASSOCIATION: ( 3-phosphoshikimate 1-carboxyvinyltransferase ) PROTEIN_CLASS: 2.5.1.19 SUBSYSTEM: chorismate biosynthesis SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-phosphoshikimate 1-carboxyvinyltransferase

248564
type: SpeciesReference
stoichiometry: 1.0
species: 207242

248552
type: SpeciesReference
stoichiometry: 1.0
species: 207512

207512
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-enolpyruvyl-shikimate-3-phosphate

248540
type: SpeciesReference
stoichiometry: 1.0
species: 207349

207349
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoenolpyruvate

248528
type: SpeciesReference
stoichiometry: 1.0
species: 207354

207574
type: Reaction
name: NA
fast: false
product: 244127
product: 244115
reversible: false
reactant: 244103
notes: GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) PROTEIN_CLASS: 1.17.4.1 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ SIDE: WATER COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
product: 244139
reactant: 244091

244127
type: SpeciesReference
stoichiometry: 1.0
species: 207562

244115
type: SpeciesReference
stoichiometry: 1.0
species: 207347

244103
type: SpeciesReference
stoichiometry: 1.0
species: 207561

207561
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a reduced thioredoxin

244139
type: SpeciesReference
stoichiometry: 1.0
species: 207265

244091
type: SpeciesReference
stoichiometry: 1.0
species: 207384

207830
type: Reaction
reactant: 254673
fast: false
name: NA
reactant: 254685
reactant: 254697
product: 254709
product: 254733
notes: GENE_ASSOCIATION: ( BCI_0558_ispH ) PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN ) PROTEIN_CLASS: 1.17.1.2 SUBSYSTEM: methylerythritol phosphate pathway SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP SIDE: WATER COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
product: 254721
reversible: false

254673
type: SpeciesReference
stoichiometry: 1.0
species: 207267

254685
type: SpeciesReference
stoichiometry: 1.0
species: 207264

254697
type: SpeciesReference
stoichiometry: 1.0
species: 207268

254709
type: SpeciesReference
stoichiometry: 1.0
species: 207269

254733
type: SpeciesReference
stoichiometry: 1.0
species: 207265

254721
type: SpeciesReference
stoichiometry: 1.0
species: 207270

207638
type: Reaction
fast: false
notes: GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis II SIDE: CPD__45__249 SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__ SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__ GENERIC: true TYPE: small HOLE: false
reactant: 246785
reactant: 246773
product: 246797
name: NA
product: 246809
reversible: false
reactant: 246761

246785
type: SpeciesReference
stoichiometry: 1.0
species: 207533

246773
type: SpeciesReference
stoichiometry: 1.0
species: 207535

246797
type: SpeciesReference
stoichiometry: 1.0
species: 207537

246809
type: SpeciesReference
stoichiometry: 1.0
species: 207545

246761
type: SpeciesReference
stoichiometry: 1.0
species: 207536

207405
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

207723
type: Reaction
product: 250245
product: 250233
reactant: 250221
reactant: 250209
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: ADP COFACTOR: UDP COFACTOR: ATP COFACTOR: ADP COFACTOR: UTP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

250245
type: SpeciesReference
stoichiometry: 1.0
species: 207445

207445
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UTP

250233
type: SpeciesReference
stoichiometry: 1.0
species: 207243

250221
type: SpeciesReference
stoichiometry: 1.0
species: 207238

250209
type: SpeciesReference
stoichiometry: 1.0
species: 207425

207688
type: Reaction
reactant: 248890
product: 248938
reactant: 248902
fast: false
reversible: false
product: 248914
notes: GENE_ASSOCIATION: ( BCI_0602_ribH ) PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase ) PROTEIN_CLASS: NA SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
product: 248926
name: NA

248890
type: SpeciesReference
stoichiometry: 1.0
species: 207505

248938
type: SpeciesReference
stoichiometry: 1.0
species: 207242

248902
type: SpeciesReference
stoichiometry: 1.0
species: 207507

207507
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione

248914
type: SpeciesReference
stoichiometry: 1.0
species: 207508

248926
type: SpeciesReference
stoichiometry: 2.0
species: 207265

207304
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-decaprenyl diphosphate

207292
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-homocysteine

207731
type: Reaction
reactant: 250618
product: 250642
product: 250654
reactant: 250594
notes: GENE_ASSOCIATION: ( BCI_0288_nadE ) PROTEIN_ASSOCIATION: ( NAD synthetase//NAD-SYNTH-NH3-RXN ) PROTEIN_CLASS: 6.3.1.5 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: AMMONIA SIDE: ATP SIDE: PPI SIDE: AMP COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
product: 250630
fast: false
name: NAD(+) synthetase
reversible: false
reactant: 250606

250618
type: SpeciesReference
stoichiometry: 1.0
species: 207238

250642
type: SpeciesReference
stoichiometry: 1.0
species: 207365

207365
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: AMP

250654
type: SpeciesReference
stoichiometry: 1.0
species: 207250

250594
type: SpeciesReference
stoichiometry: 1.0
species: 207319

207319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: deamido-NAD

250630
type: SpeciesReference
stoichiometry: 1.0
species: 207280

250606
type: SpeciesReference
stoichiometry: 1.0
species: 207293

207696
type: Reaction
product: 249241
product: 249229
reactant: 249217
reactant: 249204
notes: GENE_ASSOCIATION: ( BCI_0017_metE ) PROTEIN_ASSOCIATION: ( 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase//HOMOCYSMET-RXN ) PROTEIN_CLASS: 2.1.1.14 SUBSYSTEM: methionine biosynthesis I SUBSYSTEM: S-adenosyl-L-methionine cycle SIDE: CPD__45__1302 SIDE: CPD__45__1301 GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase

249241
type: SpeciesReference
stoichiometry: 1.0
species: 207498

207498
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: tetrahydropteroyltri-L-glutamate

249229
type: SpeciesReference
stoichiometry: 1.0
species: 207479

249217
type: SpeciesReference
stoichiometry: 1.0
species: 207497

207497
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-methyltetrahydropteroyltri-L-glutamate

249204
type: SpeciesReference
stoichiometry: 1.0
species: 207292

207279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: orotate

207368
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: geranyl-diphosphate

207568
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-undecaprenyl diphosphate

207819
type: Reaction
product: 254229
reactant: 254217
notes: GENE_ASSOCIATION: ( BCI_0400_hisA ) PROTEIN_ASSOCIATION: ( 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)//PRIBFAICARPISOM-RXN ) PROTEIN_CLASS: 5.3.1.16 SUBSYSTEM: histidine biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4- imidazole carboxamide isomerase

254229
type: SpeciesReference
stoichiometry: 1.0
species: 207300

207300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: phosphoribulosylformimino-AICAR-P

254217
type: SpeciesReference
stoichiometry: 1.0
species: 207299

207781
type: Reaction
product: 252625
reactant: 252613
reactant: 252601
notes: GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 3.5.4.9 SUBSYSTEM: tetrahydrofolate biosynthesis II SIDE: WATER GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: NA

252625
type: SpeciesReference
stoichiometry: 1.0
species: 207375

207375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an N10-formyl-tetrahydrofolate

252613
type: SpeciesReference
stoichiometry: 1.0
species: 207265

252601
type: SpeciesReference
stoichiometry: 1.0
species: 207374

207374
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5,10-methenyl-tetrahydropteroyl-[&gamma;-Glu](n)

207370
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: xanthosine-5-phosphate

207589
type: Reaction
product: 244730
product: 244718
reactant: 244706
reactant: 244694
notes: GENE_ASSOCIATION: ( BCI_0637_folP ) PROTEIN_ASSOCIATION: ( dihydropteroate synthase ) PROTEIN_CLASS: 2.5.1.15 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydropteroate synthase

244730
type: SpeciesReference
stoichiometry: 1.0
species: 207280

244718
type: SpeciesReference
stoichiometry: 1.0
species: 207560

244706
type: SpeciesReference
stoichiometry: 1.0
species: 207464

207464
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate

244694
type: SpeciesReference
stoichiometry: 1.0
species: 207410

207272
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a tetrahydrofolate polyglutamate

207719
type: Reaction
product: 250101
product: 250089
reactant: 250077
reactant: 250064
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: purine nucleotides de novo biosynthesis I COFACTOR: ATP COFACTOR: GDP COFACTOR: ADP COFACTOR: GTP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

250101
type: SpeciesReference
stoichiometry: 1.0
species: 207380

250089
type: SpeciesReference
stoichiometry: 1.0
species: 207243

250077
type: SpeciesReference
stoichiometry: 1.0
species: 207384

250064
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207756
type: Reaction
product: 251624
product: 251612
reactant: 251600
reactant: 251588
notes: GENE_ASSOCIATION: ( BCI_0275_dxs ) PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose-5-phosphate synthase (1-deoxyxylulose- 5-phosphate synthase) (DXP synthase) (DXPS)//DXS-RXN//1-deoxy-D-xylulose-5-phosphate synthase ) PROTEIN_CLASS: 2.2.1.7 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SUBSYSTEM: methylerythritol phosphate pathway SUBSYSTEM: thiamine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

251624
type: SpeciesReference
stoichiometry: 1.0
species: 207422

251612
type: SpeciesReference
stoichiometry: 1.0
species: 207359

251600
type: SpeciesReference
stoichiometry: 1.0
species: 207249

251588
type: SpeciesReference
stoichiometry: 1.0
species: 207259

207806
type: Reaction
product: 253758
product: 253746
reactant: 253734
reactant: 253722
notes: GENE_ASSOCIATION: ( BCI_0234_nadD ) PROTEIN_ASSOCIATION: ( Probable nicotinate-nucleotide adenylyltransferase (Deamido-NAD(+) pyrophosphorylase) (Deamido-NAD(+) diphosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase)//NICON ) PROTEIN_CLASS: 2.7.7.18 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Nicotinate-nucleotide adenylyltransferase

253758
type: SpeciesReference
stoichiometry: 1.0
species: 207319

253746
type: SpeciesReference
stoichiometry: 1.0
species: 207280

253734
type: SpeciesReference
stoichiometry: 1.0
species: 207238

253722
type: SpeciesReference
stoichiometry: 1.0
species: 207318

207318
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: nicotinate nucleotide

207606
type: Reaction
reversible: false
reactant: 245419
name: glutathione synthetase
fast: false
reactant: 245432
product: 245480
product: 245456
notes: GENE_ASSOCIATION: ( BCI_0482_gshB ) PROTEIN_ASSOCIATION: ( glutathione synthetase//GLUTATHIONE-SYN-RXN ) PROTEIN_CLASS: 6.3.2.3 SUBSYSTEM: glutathione biosynthesis SIDE: ATP SIDE: GLY SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
reactant: 245444
product: 245468

245419
type: SpeciesReference
stoichiometry: 1.0
species: 207418

207418
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-&gamma;-glutamylcysteine

245432
type: SpeciesReference
stoichiometry: 1.0
species: 207238

245480
type: SpeciesReference
stoichiometry: 1.0
species: 207243

245456
type: SpeciesReference
stoichiometry: 1.0
species: 207428

207428
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: glutathione

245444
type: SpeciesReference
stoichiometry: 1.0
species: 207314

245468
type: SpeciesReference
stoichiometry: 1.0
species: 207242

207751
type: Reaction
product: 251416
reactant: 251404
reactant: 251391
notes: GENE_ASSOCIATION: ( BCI_0120_purE ) or ( BCI_0119_purK ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase, catalytic subunit ) or ( phosphoribosylaminoimidazole carboxylase ATPase subunit ) PROTEIN_CLASS: 4.1.1.21 SUBSYSTEM: purine nucleotides de novo biosynthesis II SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosylaminoimidazole carboxylase

251416
type: SpeciesReference
stoichiometry: 1.0
species: 207245

207245
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-carboxyaminoimidazole ribonucleotide

251404
type: SpeciesReference
stoichiometry: 1.0
species: 207359

251391
type: SpeciesReference
stoichiometry: 1.0
species: 207247

207247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-aminoimidazole ribonucleotide

207765
type: Reaction
product: 251983
product: 251971
reactant: 251958
reactant: 251945
notes: GENE_ASSOCIATION: ( BCI_0394_folE ) PROTEIN_ASSOCIATION: ( GTP cyclohydrolase I ) PROTEIN_CLASS: 3.5.4.16 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: tetrahydrobioprein biosynthesis I SIDE: WATER SIDE: FORMATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: GTP cyclohydrolase I

251983
type: SpeciesReference
stoichiometry: 1.0
species: 207408

207408
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-dihydroneopterin triphosphate

251971
type: SpeciesReference
stoichiometry: 1.0
species: 207328

251958
type: SpeciesReference
stoichiometry: 1.0
species: 207265

251945
type: SpeciesReference
stoichiometry: 1.0
species: 207380

207633
type: Reaction
product: 246591
product: 246579
reactant: 246567
reactant: 246555
notes: GENE_ASSOCIATION: ( BCI_0624_plsC ) PROTEIN_ASSOCIATION: ( 1-acyl-sn-glycerol-3-phosphate acyltransferase//1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN ) PROTEIN_CLASS: 2.3.1.51 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SIDE: __124__Fatty__45__Acyl__45__CoA__124__ SIDE: CO__45__A COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__ COFACTOR: CO__45__A GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: NA

246591
type: SpeciesReference
stoichiometry: 1.0
species: 207313

246579
type: SpeciesReference
stoichiometry: 1.0
species: 207310

246567
type: SpeciesReference
stoichiometry: 1.0
species: 207398

246555
type: SpeciesReference
stoichiometry: 1.0
species: 207397

207776
type: Reaction
name: 2-dehydro-3-deoxyphosphoheptonate aldolase
reactant: 252408
notes: GENE_ASSOCIATION: ( BCI_0191_aroH ) PROTEIN_ASSOCIATION: ( phospho-2-dehydro-3-heoxyheptonate aldolase ) PROTEIN_CLASS: 2.5.1.54 SUBSYSTEM: chorismate biosynthesis SIDE: WATER SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 252420
reversible: false
product: 252432
reactant: 252395
fast: false
product: 252444

252408
type: SpeciesReference
stoichiometry: 1.0
species: 207265

252420
type: SpeciesReference
stoichiometry: 1.0
species: 207349

252432
type: SpeciesReference
stoichiometry: 1.0
species: 207242

252395
type: SpeciesReference
stoichiometry: 1.0
species: 207387

252444
type: SpeciesReference
stoichiometry: 1.0
species: 207388

207531
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-amino-6-(5'-phosphoribitylamino)uracil

207576
type: Reaction
reactant: 244176
name: Erythrose-4-phosphate dehydrogenase
notes: GENE_ASSOCIATION: gapA PROTEIN_ASSOCIATION: NA SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage PROTEIN_CLASS: 1.2.1.72 COFACTOR: NAD COFACTOR: NADH SIDE: PROTON SIDE: WATER SIDE: NAD SIDE: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reactant: 244200
reversible: false
product: 244236
product: 244212
product: 244224
reactant: 244188

244176
type: SpeciesReference
stoichiometry: 1.0
species: 207250

244200
type: SpeciesReference
stoichiometry: 1.0
species: 207387

244236
type: SpeciesReference
stoichiometry: 1.0
species: 207253

244212
type: SpeciesReference
stoichiometry: 2.0
species: 207267

244224
type: SpeciesReference
stoichiometry: 1.0
species: 207432

244188
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207518
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L,L-diaminopimelate

207706
type: Reaction
reactant: 249580
product: 249628
reversible: false
reactant: 249592
notes: GENE_ASSOCIATION: ( BCI_0247_bioF ) PROTEIN_ASSOCIATION: ( 8-amino-7-oxononanoate synthase ) PROTEIN_CLASS: 2.3.1.47 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: CO__45__A SIDE: CARBON__45__DIOXIDE COFACTOR: CPD__45__558 COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
name: 8-amino-7-oxononanoate synthase
fast: false
product: 249616
product: 249604

249580
type: SpeciesReference
stoichiometry: 1.0
species: 207239

249628
type: SpeciesReference
stoichiometry: 1.0
species: 207359

249592
type: SpeciesReference
stoichiometry: 1.0
species: 207482

207482
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: pimeloyl-CoA

249616
type: SpeciesReference
stoichiometry: 1.0
species: 207483

249604
type: SpeciesReference
stoichiometry: 1.0
species: 207310

207784
type: Reaction
reactant: 252697
product: 252745
name: GMP synthetase (glutamine-hydrolysing)
product: 252757
reactant: 252721
fast: false
product: 252733
product: 252769
notes: GENE_ASSOCIATION: ( BCI_0650_guaA ) PROTEIN_ASSOCIATION: ( bifunctional GMP synthase/glutamine amidotransferase protein//GMP-SYN-GLUT-RXN ) PROTEIN_CLASS: 6.3.5.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER SIDE: GLN SIDE: GLT SIDE: PPI COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
reactant: 252709
reactant: 252685
reversible: false

252697
type: SpeciesReference
stoichiometry: 1.0
species: 207265

252745
type: SpeciesReference
stoichiometry: 1.0
species: 207273

252757
type: SpeciesReference
stoichiometry: 1.0
species: 207280

252721
type: SpeciesReference
stoichiometry: 1.0
species: 207238

252733
type: SpeciesReference
stoichiometry: 1.0
species: 207373

252769
type: SpeciesReference
stoichiometry: 1.0
species: 207365

252709
type: SpeciesReference
stoichiometry: 1.0
species: 207372

252685
type: SpeciesReference
stoichiometry: 1.0
species: 207370

207494
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 4-methyl-5-(&beta;-hydroxyethyl)thiazole phosphate

207670
type: Reaction
product: 248236
product: 248224
reactant: 248212
reactant: 248200
notes: GENE_ASSOCIATION: ( BCI_0418_aroE ) PROTEIN_ASSOCIATION: ( dehydroshikimate reductase//SHIKIMATE-5-DEHYDROGENASE-RXN ) PROTEIN_CLASS: 1.1.1.25 SUBSYSTEM: chorismate biosynthesis SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Shikimate 5-dehydrogenase

248236
type: SpeciesReference
stoichiometry: 1.0
species: 207275

248224
type: SpeciesReference
stoichiometry: 1.0
species: 207353

207353
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: shikimate

248212
type: SpeciesReference
stoichiometry: 1.0
species: 207274

248200
type: SpeciesReference
stoichiometry: 1.0
species: 207523

207523
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 3-dehydro-shikimate

207714
type: Reaction
product: 249896
product: 249883
reactant: 249870
notes: GENE_ASSOCIATION: ( BCI_0620_folB ) PROTEIN_ASSOCIATION: ( dihydroneopterin aldolase ) PROTEIN_CLASS: 4.1.2.25 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: GLYCOLALDEHYDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydroneopterin aldolase

249896
type: SpeciesReference
stoichiometry: 1.0
species: 207463

207463
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 6-hydroxymethyl-7,8-dihydropterin

249883
type: SpeciesReference
stoichiometry: 1.0
species: 207475

207475
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: glycolaldehyde

249870
type: SpeciesReference
stoichiometry: 1.0
species: 207474

207474
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 7,8-dihydro-D-neopterin

207594
type: Reaction
product: 244972
fast: false
reactant: 244936
product: 244984
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0071_purC ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole-succinocarboxamide synthase//SAICARSYN-RXN ) PROTEIN_CLASS: 6.3.2.6 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 244924
reactant: 244948
name: Phosphoribosylaminoimidazole-succinocarboxamide synthetase
product: 244960

244972
type: SpeciesReference
stoichiometry: 1.0
species: 207472

207472
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole

244936
type: SpeciesReference
stoichiometry: 1.0
species: 207238

244984
type: SpeciesReference
stoichiometry: 1.0
species: 207242

244924
type: SpeciesReference
stoichiometry: 1.0
species: 207383

244948
type: SpeciesReference
stoichiometry: 1.0
species: 207245

244960
type: SpeciesReference
stoichiometry: 1.0
species: 207243

207600
type: Reaction
product: 245203
product: 245191
reactant: 245179
notes: GENE_ASSOCIATION: ( BCI_0441_pyrC ) PROTEIN_ASSOCIATION: ( dihydroorotase ) PROTEIN_CLASS: 3.5.2.3 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydroorotase

245203
type: SpeciesReference
stoichiometry: 1.0
species: 207557

207557
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dihydroorotate

245191
type: SpeciesReference
stoichiometry: 1.0
species: 207265

245179
type: SpeciesReference
stoichiometry: 1.0
species: 207435

207415
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: succinate

207487
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-methyl-THF

207695
type: Reaction
product: 249192
reactant: 249180
notes: GENE_ASSOCIATION: ( BCI_0012_pgi ) PROTEIN_ASSOCIATION: ( Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)//PGLUCISOM-RXN//Glucose-6-phosphate isomerase ) PROTEIN_CLASS: 5.3.1.9 SUBSYSTEM: glycolysis I SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Glucose-6-phosphate isomerase

249192
type: SpeciesReference
stoichiometry: 1.0
species: 207379

249180
type: SpeciesReference
stoichiometry: 1.0
species: 207469

207469
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: &beta;-D-glucose-6-phosphate

207403
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: O-succinyl-L-homoserine

207810
type: Reaction
product: 253926
product: 253914
reactant: 253902
reactant: 253890
notes: GENE_ASSOCIATION: ( BCI_0504_murB ) PROTEIN_ASSOCIATION: ( UDP-N-acetylenolpyruvoylglucosamine reductase//UDPNACETYLMURAMATEDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.158 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: UDP-N-acetylmuramate dehydrogenase

253926
type: SpeciesReference
stoichiometry: 1.0
species: 207275

253914
type: SpeciesReference
stoichiometry: 1.0
species: 207237

253902
type: SpeciesReference
stoichiometry: 1.0
species: 207309

207309
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-GlcNAc-enolpyruvate

253890
type: SpeciesReference
stoichiometry: 1.0
species: 207274

207625
type: Reaction
product: 246241
reactant: 246229
reactant: 246217
notes: GENE_ASSOCIATION: ( BCI_0118_adk ) PROTEIN_ASSOCIATION: ( adenylate kinase ) PROTEIN_CLASS: 2.7.4.3 SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Adenylate kinase

246241
type: SpeciesReference
stoichiometry: 2.0
species: 207243

246229
type: SpeciesReference
stoichiometry: 1.0
species: 207365

246217
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207703
type: Reaction
fast: false
product: 249459
reactant: 249423
reactant: 249447
notes: GENE_ASSOCIATION: ( BCI_0162_metF ) PROTEIN_ASSOCIATION: ( 5,10-methylenetetrahydrofolate reductase ) PROTEIN_CLASS: 1.5.1.20 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate transformations SIDE: NADH__45__P__45__OR__45__NOP SIDE: PROTON SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
name: Methylenetetrahydrofolate reductase (NADPH)
reversible: false
reactant: 249435
product: 249471

249459
type: SpeciesReference
stoichiometry: 1.0
species: 207270

249423
type: SpeciesReference
stoichiometry: 1.0
species: 207268

249447
type: SpeciesReference
stoichiometry: 1.0
species: 207267

249435
type: SpeciesReference
stoichiometry: 1.0
species: 207389

249471
type: SpeciesReference
stoichiometry: 1.0
species: 207487

207282
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: orotidine-5'-phosphate

207805
type: Reaction
product: 253710
product: 253697
reactant: 253685
reactant: 253673
notes: GENE_ASSOCIATION: ( BCI_0621_uppP ) PROTEIN_ASSOCIATION: ( Undecaprenyl-diphosphatase (Undecaprenyl pyrophosphate phosphatase) (Bacitracin resistance protein)//Undecaprenyl-diphosphatase ) PROTEIN_CLASS: 3.6.1.27 GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Undecaprenyl-diphosphatase

253710
type: SpeciesReference
stoichiometry: 1.0
species: 207327

253697
type: SpeciesReference
stoichiometry: 1.0
species: 207242

253685
type: SpeciesReference
stoichiometry: 1.0
species: 207265

253673
type: SpeciesReference
stoichiometry: 1.0
species: 207568

207835
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0119_purK ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase ATPase subunit ) PROTEIN_CLASS: 6.3.4.18 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: HCO3 SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
product: 254978
fast: false
name: NA
reactant: 254916
product: 254953
product: 254965
reversible: false
reactant: 254940
reactant: 254928

254978
type: SpeciesReference
stoichiometry: 1.0
species: 207244

207244
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N5-carboxyaminoimidazole ribonucleotide

254916
type: SpeciesReference
stoichiometry: 1.0
species: 207238

254953
type: SpeciesReference
stoichiometry: 1.0
species: 207242

254965
type: SpeciesReference
stoichiometry: 1.0
species: 207243

254940
type: SpeciesReference
stoichiometry: 1.0
species: 207248

207248
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: HCO3-

254928
type: SpeciesReference
stoichiometry: 1.0
species: 207247

207728
type: Reaction
product: 250426
product: 250414
reactant: 250402
reactant: 250390
notes: GENE_ASSOCIATION: ( BCI_0229_folK ) PROTEIN_ASSOCIATION: ( 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokina se//H2PTERIDINEPYROPHOSPHOKIN-RXN ) PROTEIN_CLASS: 2.7.6.3 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: ATP SIDE: AMP COFACTOR: ATP COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase

250426
type: SpeciesReference
stoichiometry: 1.0
species: 207365

250414
type: SpeciesReference
stoichiometry: 1.0
species: 207464

250402
type: SpeciesReference
stoichiometry: 1.0
species: 207238

250390
type: SpeciesReference
stoichiometry: 1.0
species: 207463

207614
type: Reaction
product: 245806
product: 245794
reactant: 245782
reactant: 245770
notes: GENE_ASSOCIATION: ( BCI_0605_pgpA ) PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphatase ) PROTEIN_CLASS: 3.1.3.27 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: WATER SIDE: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphatidylglycerophosphatase

245806
type: SpeciesReference
stoichiometry: 1.0
species: 207242

245794
type: SpeciesReference
stoichiometry: 1.0
species: 207455

207455
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: an L-1-phosphatidyl-glycerol

245782
type: SpeciesReference
stoichiometry: 1.0
species: 207265

245770
type: SpeciesReference
stoichiometry: 1.0
species: 207287

207664
type: Reaction
reactant: 247981
product: 248030
reactant: 247993
product: 248018
name: IMP dehydrogenase
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0651_guaB ) PROTEIN_ASSOCIATION: ( inosine-5'-monophosphate dehydrogenase//IMP-DEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.205 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: NAD SIDE: WATER SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
reactant: 248006
fast: false

247981
type: SpeciesReference
stoichiometry: 1.0
species: 207250

248030
type: SpeciesReference
stoichiometry: 1.0
species: 207370

247993
type: SpeciesReference
stoichiometry: 1.0
species: 207265

248018
type: SpeciesReference
stoichiometry: 1.0
species: 207253

248006
type: SpeciesReference
stoichiometry: 1.0
species: 207382

207382
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: inosine-5'-phosphate

207639
type: Reaction
product: 246859
product: 246846
reactant: 246834
reactant: 246822
notes: GENE_ASSOCIATION: ( BCI_0398_hisI ) PROTEIN_ASSOCIATION: ( phosphoribosyl-AMP cyclohydrolase//HISTCYCLOHYD-RXN ) PROTEIN_CLASS: 3.6.1.31 SUBSYSTEM: histidine biosynthesis I SIDE: WATER SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosyl-ATP pyrophosphatase

246859
type: SpeciesReference
stoichiometry: 1.0
species: 207502

246846
type: SpeciesReference
stoichiometry: 1.0
species: 207280

246834
type: SpeciesReference
stoichiometry: 1.0
species: 207265

246822
type: SpeciesReference
stoichiometry: 1.0
species: 207543

207595
type: Reaction
product: 245034
product: 245021
reactant: 245008
reactant: 244996
notes: GENE_ASSOCIATION: ( BCI_0405_hisG ) PROTEIN_ASSOCIATION: ( ATP phosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.17 SUBSYSTEM: histidine biosynthesis I SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: ATP phosphoribosyltransferase

245034
type: SpeciesReference
stoichiometry: 1.0
species: 207280

245021
type: SpeciesReference
stoichiometry: 1.0
species: 207543

245008
type: SpeciesReference
stoichiometry: 1.0
species: 207238

244996
type: SpeciesReference
stoichiometry: 1.0
species: 207278

207278
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-phosphoribosyl 1-pyrophosphate

207779
type: Reaction
product: 252541
reactant: 252529
notes: GENE_ASSOCIATION: ( BCI_0041_thiC ) PROTEIN_ASSOCIATION: ( thiamine biosynthesis protein ThiC ) PROTEIN_CLASS: NA SUBSYSTEM: thiamine biosynthesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

252541
type: SpeciesReference
stoichiometry: 1.0
species: 207378

252529
type: SpeciesReference
stoichiometry: 1.0
species: 207247

207519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: meso-diaminopimelate

207656
type: Reaction
name: CTP synthetase
product: 247631
reactant: 247607
notes: GENE_ASSOCIATION: ( BCI_0222_pyrG ) PROTEIN_ASSOCIATION: ( CTP synthase (UTP--ammonia ligase) (CTP synthetase)//CTPSYN-RXN//CTP synthase ) PROTEIN_CLASS: 6.3.4.2 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: WATER SIDE: GLN SIDE: ADP SIDE: GLT SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
product: 247667
reactant: 247595
reversible: false
product: 247643
reactant: 247619
reactant: 247582
product: 247655

247631
type: SpeciesReference
stoichiometry: 1.0
species: 207243

247607
type: SpeciesReference
stoichiometry: 1.0
species: 207372

247667
type: SpeciesReference
stoichiometry: 1.0
species: 207312

247595
type: SpeciesReference
stoichiometry: 1.0
species: 207265

247643
type: SpeciesReference
stoichiometry: 1.0
species: 207273

247619
type: SpeciesReference
stoichiometry: 1.0
species: 207445

247582
type: SpeciesReference
stoichiometry: 1.0
species: 207238

247655
type: SpeciesReference
stoichiometry: 1.0
species: 207242

207741
type: Reaction
product: 251017
product: 251004
reactant: 250992
reactant: 250980
notes: GENE_ASSOCIATION: ( BCI_0139_glmU ) PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P- ) PROTEIN_CLASS: 2.7.7.23 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: UTP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: UDP-N-acetylglucosamine pyrophosphorylase

251017
type: SpeciesReference
stoichiometry: 1.0
species: 207423

251004
type: SpeciesReference
stoichiometry: 1.0
species: 207280

250992
type: SpeciesReference
stoichiometry: 1.0
species: 207447

207447
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: N-acetyl-glucosamine-1-phosphate

250980
type: SpeciesReference
stoichiometry: 1.0
species: 207445

207799
type: Reaction
product: 253396
product: 253384
reactant: 253372
reactant: 253360
notes: GENE_ASSOCIATION: ( BCI_0611_nadK ) PROTEIN_ASSOCIATION: ( ATP-dependent NAD Kinase ) PROTEIN_CLASS: 2.7.1.23 SUBSYSTEM: NAD phosphorylation and dephosphorylation SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NAD(+) kinase

253396
type: SpeciesReference
stoichiometry: 1.0
species: 207275

253384
type: SpeciesReference
stoichiometry: 1.0
species: 207243

253372
type: SpeciesReference
stoichiometry: 1.0
species: 207250

253360
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207399
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dCTP

207514
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: fructose-1,6-bisphosphate

207729
type: Reaction
reversible: false
fast: false
product: 250486
reactant: 250450
reactant: 250438
name: Histidinol dehydrogenase
notes: GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 SUBSYSTEM: histidine biosynthesis I SIDE: NAD SIDE: WATER SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
product: 250474
reactant: 250462

250486
type: SpeciesReference
stoichiometry: 1.0
species: 207253

250450
type: SpeciesReference
stoichiometry: 1.0
species: 207265

250438
type: SpeciesReference
stoichiometry: 1.0
species: 207250

250474
type: SpeciesReference
stoichiometry: 1.0
species: 207367

207367
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-histidine

250462
type: SpeciesReference
stoichiometry: 1.0
species: 207357

207357
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: histidinal

207686
type: Reaction
product: 248878
product: 248866
reactant: 248854
reactant: 248842
notes: GENE_ASSOCIATION: ( BCI_0292_ispE ) PROTEIN_ASSOCIATION: ( 4-diphosphocytidyl-2C-methyl-D-erythritol kinase//2.7.1.148-RXN ) PROTEIN_CLASS: 2.7.1.148 SUBSYSTEM: methylerythritol phosphate pathway SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase

248878
type: SpeciesReference
stoichiometry: 1.0
species: 207243

248866
type: SpeciesReference
stoichiometry: 1.0
species: 207477

207477
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol

248854
type: SpeciesReference
stoichiometry: 1.0
species: 207405

248842
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207816
type: Reaction
product: 254156
product: 254144
reactant: 254132
reactant: 254120
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

254156
type: SpeciesReference
stoichiometry: 1.0
species: 207295

254144
type: SpeciesReference
stoichiometry: 1.0
species: 207280

254132
type: SpeciesReference
stoichiometry: 1.0
species: 207303

254120
type: SpeciesReference
stoichiometry: 1.0
species: 207294

207760
type: Reaction
name: NA
notes: GENE_ASSOCIATION: ( BCI_0163_metB ) PROTEIN_ASSOCIATION: ( O-succinylhomoserine (thiol)-lyase//METBALT-RXN//O-SUCCHOMOSERLYASE-RXN ) PROTEIN_CLASS: 2.5.1.48 GENERIC: false TYPE: small HOLE: false
product: 251812
reactant: 251788
reversible: true
reactant: 251800
fast: false
reactant: 251776
product: 251824

251812
type: SpeciesReference
stoichiometry: 1.0
species: 207403

251788
type: SpeciesReference
stoichiometry: 1.0
species: 207293

251800
type: SpeciesReference
stoichiometry: 1.0
species: 207415

251776
type: SpeciesReference
stoichiometry: 1.0
species: 207414

207414
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-oxobutanoate

251824
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207605
type: Reaction
product: 245407
product: 245395
reactant: 245383
reactant: 245371
notes: GENE_ASSOCIATION: ( BCI_0272_panE ) PROTEIN_ASSOCIATION: ( 2-dehydropantoate 2-reductase ) PROTEIN_CLASS: 1.1.1.169 SUBSYSTEM: pantothenate biosynthesis I SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 2-dehydropantoate 2-reductase

245407
type: SpeciesReference
stoichiometry: 1.0
species: 207362

207362
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: L-pantoate

245395
type: SpeciesReference
stoichiometry: 1.0
species: 207275

245383
type: SpeciesReference
stoichiometry: 1.0
species: 207274

245371
type: SpeciesReference
stoichiometry: 1.0
species: 207504

207824
type: Reaction
product: 254433
product: 254421
reactant: 254409
reactant: 254397
notes: GENE_ASSOCIATION: ( BCI_0254_cmk ) PROTEIN_ASSOCIATION: ( cytidylate kinase ) PROTEIN_CLASS: 2.7.4.14 SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Cytidylate kinase

254433
type: SpeciesReference
stoichiometry: 1.0
species: 207289

254421
type: SpeciesReference
stoichiometry: 1.0
species: 207243

254409
type: SpeciesReference
stoichiometry: 1.0
species: 207238

254397
type: SpeciesReference
stoichiometry: 1.0
species: 207288

207308
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: fumarate

207584
type: Reaction
product: 244561
reactant: 244549
notes: GENE_ASSOCIATION: ( BCI_0153_murI ) PROTEIN_ASSOCIATION: ( glutamate racemase ) PROTEIN_CLASS: 5.1.1.3 SUBSYSTEM: peptidoglycan biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Glutamate racemase

244561
type: SpeciesReference
stoichiometry: 1.0
species: 207556

207556
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glutamate

244549
type: SpeciesReference
stoichiometry: 1.0
species: 207273

207648
type: Reaction
product: 247194
reactant: 247182
notes: GENE_ASSOCIATION: ( BCI_0647_rpiA ) PROTEIN_ASSOCIATION: ( ribose-5-phosphate isomerase A//RIB5PISOM-RXN ) PROTEIN_CLASS: 5.3.1.6 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Ribose 5-phosphate epimerase

247194
type: SpeciesReference
stoichiometry: 1.0
species: 207360

247182
type: SpeciesReference
stoichiometry: 1.0
species: 207342

207342
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-ribose-5-phosphate

207671
type: Reaction
product: 248261
reactant: 248249
notes: GENE_ASSOCIATION: ( BCI_0125_dapF ) PROTEIN_ASSOCIATION: ( diaminopimelate epimerase ) PROTEIN_CLASS: 5.1.1.7 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: aspartate superpathway GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Diaminopimelate epimerase

248261
type: SpeciesReference
stoichiometry: 1.0
species: 207519

248249
type: SpeciesReference
stoichiometry: 1.0
species: 207518

207744
type: Reaction
product: 251113
product: 251101
reactant: 251089
reactant: 251077
notes: GENE_ASSOCIATION: ( BCI_0382_ackA ) PROTEIN_ASSOCIATION: ( acetate kinase//ACETATEKIN-RXN ) PROTEIN_CLASS: 2.7.2.1 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: acetate formation from acetyl-CoA I SUBSYSTEM: pyruvate fermentation to acetate II SUBSYSTEM: pyruvate fermentation to acetate IV SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Acetate kinase

251113
type: SpeciesReference
stoichiometry: 1.0
species: 207243

251101
type: SpeciesReference
stoichiometry: 1.0
species: 207440

251089
type: SpeciesReference
stoichiometry: 1.0
species: 207439

251077
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207794
type: Reaction
product: 253214
reactant: 253202
reactant: 253190
notes: GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 3.5.4.9 SUBSYSTEM: reductive acetyl coenzyme A pathway SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway) SUBSYSTEM: folate transformations SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Methenyltetrahydrofolate cyclohydrolase

253214
type: SpeciesReference
stoichiometry: 1.0
species: 207255

253202
type: SpeciesReference
stoichiometry: 1.0
species: 207265

253190
type: SpeciesReference
stoichiometry: 1.0
species: 207350

207680
type: Reaction
reversible: false
reactant: 248588
reactant: 248576
product: 248637
reactant: 248600
name: NA
notes: GENE_ASSOCIATION: ( BCI_0510_lpdA ) or ( BCI_0512_aceE ) or ( BCI_0511_aceF ) PROTEIN_ASSOCIATION: ( pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase ) or ( pyruvate dehydrogenase subunit E1//RXN0-1134 ) or ( pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase ) PROTEIN_CLASS: 1.2.1.- SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: pyruvate fermentation to acetate II SIDE: CO__45__A SIDE: NAD SIDE: NADH COFACTOR: CO__45__A COFACTOR: NAD COFACTOR: ACETYL__45__COA COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
product: 248612
fast: false
product: 248624

248588
type: SpeciesReference
stoichiometry: 1.0
species: 207259

248576
type: SpeciesReference
stoichiometry: 1.0
species: 207310

248637
type: SpeciesReference
stoichiometry: 1.0
species: 207253

248600
type: SpeciesReference
stoichiometry: 1.0
species: 207250

248612
type: SpeciesReference
stoichiometry: 1.0
species: 207485

248624
type: SpeciesReference
stoichiometry: 1.0
species: 207359

207337
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate

207573
type: Reaction
reactant: 244018
product: 244043
reactant: 244006
product: 244030
product: 244055
reactant: 243994
fast: false
product: 244079
product: 244067
notes: GENE_ASSOCIATION: ( BCI_0045_thiG ) or ( BCI_0046_thiH ) PROTEIN_ASSOCIATION: ( thiazole synthase ) or ( thiH protein ) PROTEIN_CLASS: NA SUBSYSTEM: thiamine biosynthesis SIDE: _4__45__HYDROXY__45__BENZYL__45__ALCOHOL SIDE: __124__ThiF__45__Proteins__124__ SIDE: CARBON__45__DIOXIDE GENERIC: true TYPE: macro HOLE: false
reversible: false
name: NA

244018
type: SpeciesReference
stoichiometry: 1.0
species: 207422

244043
type: SpeciesReference
stoichiometry: 1.0
species: 207566

244006
type: SpeciesReference
stoichiometry: 1.0
species: 207563

244030
type: SpeciesReference
stoichiometry: 1.0
species: 207565

207565
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a ThiS sulfur-carrier protein

244055
type: SpeciesReference
stoichiometry: 1.0
species: 207494

243994
type: SpeciesReference
stoichiometry: 1.0
species: 207520

244079
type: SpeciesReference
stoichiometry: 1.0
species: 207359

244067
type: SpeciesReference
stoichiometry: 1.0
species: 207567

207567
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a ThiF protein

207811
type: Reaction
product: 253963
product: 253950
reactant: 253938
notes: GENE_ASSOCIATION: ( BCI_0420_fumC ) PROTEIN_ASSOCIATION: ( fumarate hydratase ) PROTEIN_CLASS: 4.2.1.2 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: TCA cycle variation II SUBSYSTEM: TCA cycle SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Fumarate hydratase

253963
type: SpeciesReference
stoichiometry: 1.0
species: 207308

253950
type: SpeciesReference
stoichiometry: 1.0
species: 207265

253938
type: SpeciesReference
stoichiometry: 1.0
species: 207307

207619
type: Reaction
reactant: 245975
fast: false
reactant: 245963
product: 245987
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: folate polyglutamylation I SIDE: ATP SIDE: GLT SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
product: 245999
reversible: false
reactant: 245950
name: NA
product: 246011

245975
type: SpeciesReference
stoichiometry: 1.0
species: 207551

207551
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: a 5,10-methylene-tetrahydrofolate

245963
type: SpeciesReference
stoichiometry: 1.0
species: 207273

245987
type: SpeciesReference
stoichiometry: 1.0
species: 207242

245999
type: SpeciesReference
stoichiometry: 1.0
species: 207551

245950
type: SpeciesReference
stoichiometry: 1.0
species: 207238

246011
type: SpeciesReference
stoichiometry: 1.0
species: 207243

207581
type: Reaction
product: 244453
reactant: 244417
product: 244465
fast: false
product: 244441
reactant: 244429
name: GMP synthetase
reactant: 244404
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0650_guaA ) PROTEIN_ASSOCIATION: ( bifunctional GMP synthase/glutamine amidotransferase protein//GMP-SYN-GLUT-RXN ) PROTEIN_CLASS: 6.3.4.1 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: AMMONIA SIDE: PPI COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false

244453
type: SpeciesReference
stoichiometry: 1.0
species: 207373

244417
type: SpeciesReference
stoichiometry: 1.0
species: 207238

244465
type: SpeciesReference
stoichiometry: 1.0
species: 207365

244441
type: SpeciesReference
stoichiometry: 1.0
species: 207280

244429
type: SpeciesReference
stoichiometry: 1.0
species: 207370

244404
type: SpeciesReference
stoichiometry: 1.0
species: 207293

207711
type: Reaction
product: 249810
product: 249798
reactant: 249786
notes: GENE_ASSOCIATION: ( BCI_0210_ispF ) PROTEIN_ASSOCIATION: ( 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase//RXN0-302 ) PROTEIN_CLASS: 4.6.1.12 SUBSYSTEM: methylerythritol phosphate pathway SIDE: CMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

249810
type: SpeciesReference
stoichiometry: 1.0
species: 207288

249798
type: SpeciesReference
stoichiometry: 1.0
species: 207260

249786
type: SpeciesReference
stoichiometry: 1.0
species: 207477

207540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: S-adenosyl-4-methylthio-2-oxobutanoate

207761
type: Reaction
product: 251860
product: 251848
reactant: 251836
notes: GENE_ASSOCIATION: ( BCI_0423_purB ) PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN ) PROTEIN_CLASS: 4.3.2.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: FUM GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Adenylosuccinate lyase

251860
type: SpeciesReference
stoichiometry: 1.0
species: 207365

251848
type: SpeciesReference
stoichiometry: 1.0
species: 207308

251836
type: SpeciesReference
stoichiometry: 1.0
species: 207385

207385
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: adenylo-succinate

207332
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-alanyl-D-alanine

207515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: porphobilinogen

207736
type: Reaction
product: 250811
product: 250799
reactant: 250787
notes: GENE_ASSOCIATION: ( BCI_0305_cls ) PROTEIN_ASSOCIATION: ( cardiolipin synthetase ) PROTEIN_CLASS: 2.7.8.- SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: GLYCEROL GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: NA

250811
type: SpeciesReference
stoichiometry: 1.0
species: 207458

207458
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: glycerol

250799
type: SpeciesReference
stoichiometry: 1.0
species: 207457

207457
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: cardiolipin

250787
type: SpeciesReference
stoichiometry: 2.0
species: 207455

207786
type: Reaction
reversible: true
product: 252865
name: NA
notes: GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
reactant: 252829
product: 252877
fast: false
product: 252853
reactant: 252841

252865
type: SpeciesReference
stoichiometry: 2.0
species: 207267

252829
type: SpeciesReference
stoichiometry: 1.0
species: 207345

252877
type: SpeciesReference
stoichiometry: 2.0
species: 207253

252853
type: SpeciesReference
stoichiometry: 1.0
species: 207367

252841
type: SpeciesReference
stoichiometry: 2.0
species: 207250

207775
type: Reaction
product: 252383
product: 252371
reactant: 252359
reactant: 252347
notes: GENE_ASSOCIATION: ( BCI_0182_dut ) PROTEIN_ASSOCIATION: ( deoxyuridine 5''-triphosphate nucleotidohydrolase//DUTP-PYROP-RXN ) PROTEIN_CLASS: 3.6.1.23 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: WATER SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: dUTP pyrophosphatase

252383
type: SpeciesReference
stoichiometry: 1.0
species: 207392

207392
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dUMP

252371
type: SpeciesReference
stoichiometry: 1.0
species: 207280

252359
type: SpeciesReference
stoichiometry: 1.0
species: 207390

252347
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207789
type: Reaction
product: 252997
product: 252985
reactant: 252973
reactant: 252961
notes: GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 SUBSYSTEM: histidine biosynthesis I SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Histidinol dehydrogenase

252997
type: SpeciesReference
stoichiometry: 1.0
species: 207253

252985
type: SpeciesReference
stoichiometry: 1.0
species: 207357

252973
type: SpeciesReference
stoichiometry: 1.0
species: 207250

252961
type: SpeciesReference
stoichiometry: 1.0
species: 207345

207473
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 6-pyruvoyl tetrahydropterin

207643
type: Reaction
product: 247022
product: 247010
reactant: 246998
reactant: 246986
notes: GENE_ASSOCIATION: ( BCI_0245_bioA ) PROTEIN_ASSOCIATION: ( adenosylmethionine--8-amino-7-oxononanoate transaminase ) PROTEIN_CLASS: 2.6.1.62 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: S__45__ADENOSYLMETHIONINE SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Adenosylmethionine--8-amino-7-oxononanoate aminotransferase

247022
type: SpeciesReference
stoichiometry: 1.0
species: 207541

247010
type: SpeciesReference
stoichiometry: 1.0
species: 207540

246998
type: SpeciesReference
stoichiometry: 1.0
species: 207483

246986
type: SpeciesReference
stoichiometry: 1.0
species: 207460

207783
type: Reaction
product: 252673
product: 252661
reactant: 252649
reactant: 252637
notes: GENE_ASSOCIATION: ( BCI_0293_prsA ) PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase//PRPPSYN-RXN ) PROTEIN_CLASS: 2.7.6.1 SUBSYSTEM: PRPP biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SIDE: ATP COFACTOR: ATP COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: ribose-phosphate diphosphokinase

252673
type: SpeciesReference
stoichiometry: 1.0
species: 207278

252661
type: SpeciesReference
stoichiometry: 1.0
species: 207365

252649
type: SpeciesReference
stoichiometry: 1.0
species: 207342

252637
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207705
type: Reaction
product: 249568
product: 249556
reactant: 249543
reactant: 249531
notes: GENE_ASSOCIATION: ( BCI_0176_coaD ) PROTEIN_ASSOCIATION: ( pantetheine-phosphate adenylyltransferase ) PROTEIN_CLASS: 2.7.7.3 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Pantetheine-phosphate adenylyltransferase

249568
type: SpeciesReference
stoichiometry: 1.0
species: 207484

207484
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dephospho-CoA

249556
type: SpeciesReference
stoichiometry: 1.0
species: 207280

249543
type: SpeciesReference
stoichiometry: 1.0
species: 207467

249531
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207651
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0513_nadC ) PROTEIN_ASSOCIATION: ( nicotinate-nucleotide pyrophosphorylase//QUINOPRIBOTRANS-RXN ) PROTEIN_CLASS: 2.4.2.19 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: CARBON__45__DIOXIDE SIDE: PPI SIDE: PRPP GENERIC: false TYPE: small HOLE: false
product: 247387
reactant: 247363
fast: false
reversible: false
name: Nicotinate-nucleotide pyrophosphorylase (carboxylating)
product: 247400
reactant: 247350
reactant: 247375

247387
type: SpeciesReference
stoichiometry: 1.0
species: 207278

247363
type: SpeciesReference
stoichiometry: 1.0
species: 207280

247400
type: SpeciesReference
stoichiometry: 1.0
species: 207452

207452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: quinolinate

247350
type: SpeciesReference
stoichiometry: 1.0
species: 207359

247375
type: SpeciesReference
stoichiometry: 1.0
species: 207318

207713
type: Reaction
product: 249858
product: 249846
reactant: 249834
reactant: 249822
notes: GENE_ASSOCIATION: ( BCI_0555_ribF ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibF ) PROTEIN_CLASS: 2.7.7.2 SUBSYSTEM: flavin biosynthesis SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: FMN adenylyltransferase

249858
type: SpeciesReference
stoichiometry: 1.0
species: 207429

249846
type: SpeciesReference
stoichiometry: 1.0
species: 207280

249834
type: SpeciesReference
stoichiometry: 1.0
species: 207238

249822
type: SpeciesReference
stoichiometry: 1.0
species: 207320

207320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: FMN

207555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dTTP

207738
type: Reaction
name: NA
reactant: 250835
product: 250847
reactant: 250823
product: 250859
notes: GENE_ASSOCIATION: ( BCI_0401_hisH ) or ( BCI_0399_hisF ) PROTEIN_ASSOCIATION: ( imidazole glycerol phosphate synthase, glutamine amidotransferase subunit ) or ( imidazole glycerol phosphate synthase subunit HisF ) PROTEIN_CLASS: 2.4.2.- SUBSYSTEM: histidine biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
reversible: false
product: 250871
fast: false

250835
type: SpeciesReference
stoichiometry: 1.0
species: 207372

250847
type: SpeciesReference
stoichiometry: 1.0
species: 207453

207453
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-erythro-imidazole-glycerol-phosphate

250823
type: SpeciesReference
stoichiometry: 1.0
species: 207300

250859
type: SpeciesReference
stoichiometry: 1.0
species: 207273

250871
type: SpeciesReference
stoichiometry: 1.0
species: 207454

207454
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: aminoimidazole carboxamide ribonucleotide

207694
type: Reaction
product: 249168
product: 249156
reactant: 249144
reactant: 249132
notes: GENE_ASSOCIATION: ( BCI_0514_coaE ) PROTEIN_ASSOCIATION: ( dephospho-CoA kinase ) PROTEIN_CLASS: 2.7.1.24 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dephospho-CoA kinase

249168
type: SpeciesReference
stoichiometry: 1.0
species: 207243

249156
type: SpeciesReference
stoichiometry: 1.0
species: 207310

249144
type: SpeciesReference
stoichiometry: 1.0
species: 207484

249132
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207548
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glucosamine-6-phosphate

207624
type: Reaction
product: 246204
product: 246192
reactant: 246180
reactant: 246167
notes: GENE_ASSOCIATION: ( BCI_0403_hisC ) PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN ) PROTEIN_CLASS: 2.6.1.9 SUBSYSTEM: histidine biosynthesis I SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Histidinol-phosphate aminotransferase

246204
type: SpeciesReference
stoichiometry: 1.0
species: 207317

246192
type: SpeciesReference
stoichiometry: 1.0
species: 207344

246180
type: SpeciesReference
stoichiometry: 1.0
species: 207542

207542
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: imidazole acetol-phosphate

246167
type: SpeciesReference
stoichiometry: 1.0
species: 207273

207720
type: Reaction
product: 250137
product: 250125
reactant: 250113
notes: GENE_ASSOCIATION: ( BCI_0423_purB ) PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN ) PROTEIN_CLASS: 4.3.2.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: FUM GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Adenylosuccinate lyase

250137
type: SpeciesReference
stoichiometry: 1.0
species: 207308

250125
type: SpeciesReference
stoichiometry: 1.0
species: 207454

250113
type: SpeciesReference
stoichiometry: 1.0
species: 207472

207685
type: Reaction
product: 248830
product: 248818
reactant: 248806
reactant: 248794
notes: GENE_ASSOCIATION: ( BCI_0075_tktA ) PROTEIN_ASSOCIATION: ( transketolase//1TRANSKETO-RXN ) PROTEIN_CLASS: 2.2.1.1 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (partial) SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Transketolase

248830
type: SpeciesReference
stoichiometry: 1.0
species: 207379

248818
type: SpeciesReference
stoichiometry: 1.0
species: 207249

248806
type: SpeciesReference
stoichiometry: 1.0
species: 207340

207340
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-xylulose-5-phosphate

248794
type: SpeciesReference
stoichiometry: 1.0
species: 207387

207770
type: Reaction
product: 252177
product: 252165
reactant: 252153
reactant: 252141
notes: GENE_ASSOCIATION: ( BCI_0395_dcd ) PROTEIN_ASSOCIATION: ( 2-deoxycytidine 5-triphosphate deaminase//DCTP-DEAM-RXN ) PROTEIN_CLASS: 3.5.4.13 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: dCTP deaminase

252177
type: SpeciesReference
stoichiometry: 1.0
species: 207293

252165
type: SpeciesReference
stoichiometry: 1.0
species: 207390

252153
type: SpeciesReference
stoichiometry: 1.0
species: 207399

252141
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207578
type: Reaction
reactant: 244248
reactant: 244260
fast: false
reactant: 244272
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.12 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SIDE: ATP SIDE: GLT SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
name: dihydrofolate synthetase
reversible: false
product: 244284
product: 244296
product: 244308

244248
type: SpeciesReference
stoichiometry: 1.0
species: 207238

244260
type: SpeciesReference
stoichiometry: 1.0
species: 207273

244272
type: SpeciesReference
stoichiometry: 1.0
species: 207560

244284
type: SpeciesReference
stoichiometry: 1.0
species: 207242

244296
type: SpeciesReference
stoichiometry: 1.0
species: 207407

244308
type: SpeciesReference
stoichiometry: 1.0
species: 207243

207804
type: Reaction
product: 253661
notes: GENE_ASSOCIATION: ( BCI_0523_murE ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN ) SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP PROTEIN_CLASS: 6.3.2.13 GENERIC: true TYPE: small HOLE: false
product: 253637
reactant: 253600
name: UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
reactant: 253612
reversible: false
fast: false
product: 253649
reactant: 253625

253661
type: SpeciesReference
stoichiometry: 1.0
species: 207243

253637
type: SpeciesReference
stoichiometry: 1.0
species: 207330

253600
type: SpeciesReference
stoichiometry: 1.0
species: 207337

253612
type: SpeciesReference
stoichiometry: 1.0
species: 207238

253649
type: SpeciesReference
stoichiometry: 1.0
species: 207242

253625
type: SpeciesReference
stoichiometry: 1.0
species: 207519

207834
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0443_gapA ) PROTEIN_ASSOCIATION: ( glyceraldehyde-3-phosphate dehydrogenase, type I ) PROTEIN_CLASS: 1.2.1.12 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: NAD SIDE: __124__Pi__124__ SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
product: 254904
reactant: 254855
reversible: true
fast: false
reactant: 254880
product: 254892
reactant: 254867
name: Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)

254904
type: SpeciesReference
stoichiometry: 1.0
species: 207253

254855
type: SpeciesReference
stoichiometry: 1.0
species: 207249

254880
type: SpeciesReference
stoichiometry: 1.0
species: 207242

254892
type: SpeciesReference
stoichiometry: 1.0
species: 207252

254867
type: SpeciesReference
stoichiometry: 1.0
species: 207250

207708
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0648 ) PROTEIN_ASSOCIATION: ( 5-formyltetrahydrofolate cyclo-ligase family protein//5-formyltetrahydrofolate cyclo-ligase ) PROTEIN_CLASS: 6.3.3.2 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate transformations SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
product: 249689
name: 5-formyltetrahydrofolate cyclo-ligase
reversible: true
fast: false
product: 249677
product: 249665
reactant: 249640
reactant: 249653

249689
type: SpeciesReference
stoichiometry: 1.0
species: 207242

249677
type: SpeciesReference
stoichiometry: 1.0
species: 207350

249665
type: SpeciesReference
stoichiometry: 1.0
species: 207243

249640
type: SpeciesReference
stoichiometry: 1.0
species: 207478

249653
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207513
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: D-glucosamine 1-phosphate

207759
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0201_gshA ) PROTEIN_ASSOCIATION: ( glutamate--cysteine ligase ) PROTEIN_CLASS: 6.3.2.2 SUBSYSTEM: glutathione biosynthesis SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
reactant: 251710
reactant: 251697
product: 251762
product: 251736
reversible: false
fast: false
name: Glutamate--cysteine ligase
product: 251749
reactant: 251723

251710
type: SpeciesReference
stoichiometry: 1.0
species: 207238

251697
type: SpeciesReference
stoichiometry: 1.0
species: 207273

251762
type: SpeciesReference
stoichiometry: 1.0
species: 207243

251736
type: SpeciesReference
stoichiometry: 1.0
species: 207242

251749
type: SpeciesReference
stoichiometry: 1.0
species: 207418

251723
type: SpeciesReference
stoichiometry: 1.0
species: 207417

207646
type: Reaction
product: 247169
product: 247156
reactant: 247144
reactant: 247132
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: CDP COFACTOR: ADP COFACTOR: CTP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: NA

247169
type: SpeciesReference
stoichiometry: 1.0
species: 207312

247156
type: SpeciesReference
stoichiometry: 1.0
species: 207243

247144
type: SpeciesReference
stoichiometry: 1.0
species: 207289

247132
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207791
type: Reaction
product: 253118
product: 253106
reactant: 253094
reactant: 253082
notes: GENE_ASSOCIATION: ( BCI_0024_aroK ) PROTEIN_ASSOCIATION: ( shikimate kinase I//SHIKIMATE-KINASE-RXN ) PROTEIN_CLASS: 2.7.1.71 SUBSYSTEM: chorismate biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: shikimate-kinase

253118
type: SpeciesReference
stoichiometry: 1.0
species: 207354

253106
type: SpeciesReference
stoichiometry: 1.0
species: 207243

253094
type: SpeciesReference
stoichiometry: 1.0
species: 207238

253082
type: SpeciesReference
stoichiometry: 1.0
species: 207353

207826
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0072_purM ) PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamidine cyclo-ligase ) PROTEIN_CLASS: 6.3.3.1 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
product: 254541
product: 254517
reactant: 254505
fast: false
reversible: false
product: 254529
reactant: 254493
name: phosphoribosylformylglycinamidine cyclo-ligase

254541
type: SpeciesReference
stoichiometry: 1.0
species: 207247

254517
type: SpeciesReference
stoichiometry: 1.0
species: 207242

254505
type: SpeciesReference
stoichiometry: 1.0
species: 207283

207283
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5-phosphoribosyl-N-formylglycineamidine

254529
type: SpeciesReference
stoichiometry: 1.0
species: 207243

254493
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207721
type: Reaction
name: Glucose-6-phosphate 1-dehydrogenase
product: 250173
reactant: 250149
fast: false
product: 250185
reversible: false
product: 250197
reactant: 250161
notes: GENE_ASSOCIATION: ( BCI_0309_zwf ) PROTEIN_ASSOCIATION: ( glucose-6-phosphate 1-dehydrogenase ) PROTEIN_CLASS: 1.1.1.49 SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: NADP SIDE: PROTON SIDE: NADPH COFACTOR: NADP COFACTOR: NADPH GENERIC: false TYPE: small HOLE: false

250173
type: SpeciesReference
stoichiometry: 1.0
species: 207267

250149
type: SpeciesReference
stoichiometry: 1.0
species: 207275

250185
type: SpeciesReference
stoichiometry: 1.0
species: 207274

250197
type: SpeciesReference
stoichiometry: 1.0
species: 207470

250161
type: SpeciesReference
stoichiometry: 1.0
species: 207469

207579
type: Reaction
product: 244344
product: 244332
reactant: 244320
notes: GENE_ASSOCIATION: ( BCI_0646_fbaA ) PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase ) PROTEIN_CLASS: 4.1.2.13 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Fructose-bisphosphate aldolase

244344
type: SpeciesReference
stoichiometry: 1.0
species: 207352

244332
type: SpeciesReference
stoichiometry: 1.0
species: 207249

244320
type: SpeciesReference
stoichiometry: 1.0
species: 207514

207666
type: Reaction
product: 248115
product: 248103
reactant: 248090
notes: GENE_ASSOCIATION: ( BCI_0623_ribB ) PROTEIN_ASSOCIATION: ( 3,4-dihydroxy-2-butanone 4-phosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: flavin biosynthesis SIDE: FORMATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

248115
type: SpeciesReference
stoichiometry: 1.0
species: 207505

248103
type: SpeciesReference
stoichiometry: 1.0
species: 207328

248090
type: SpeciesReference
stoichiometry: 1.0
species: 207360

207558
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: tetrahydrofolate-L-glutamate

207746
type: Reaction
product: 251209
product: 251197
reactant: 251185
reactant: 251173
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: 2.5.1.31 SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

251209
type: SpeciesReference
stoichiometry: 1.0
species: 207302

251197
type: SpeciesReference
stoichiometry: 1.0
species: 207280

251185
type: SpeciesReference
stoichiometry: 1.0
species: 207369

251173
type: SpeciesReference
stoichiometry: 1.0
species: 207294

207674
type: Reaction
product: 248347
product: 248335
reactant: 248322
reactant: 248310
notes: GENE_ASSOCIATION: ( BCI_0061_hemC ) PROTEIN_ASSOCIATION: ( Porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)//OHMETHYLBILANESYN-RXN//Hydroxymethylbilane synthase ) PROTEIN_CLASS: 2.5.1.61 SUBSYSTEM: tetrapyrrole biosynthesis I SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Hydroxymethylbilane synthase

248347
type: SpeciesReference
stoichiometry: 1.0
species: 207412

248335
type: SpeciesReference
stoichiometry: 4.0
species: 207293

248322
type: SpeciesReference
stoichiometry: 1.0
species: 207265

248310
type: SpeciesReference
stoichiometry: 4.0
species: 207515

207257
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 5'-phosphoribosyl-N-formylglycineamide

207546
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: malonyl-CoA

207740
type: Reaction
product: 250968
product: 250956
reactant: 250944
reactant: 250931
notes: GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: NA SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: PROTON SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

250968
type: SpeciesReference
stoichiometry: 1.0
species: 207359

250956
type: SpeciesReference
stoichiometry: 1.0
species: 207449

250944
type: SpeciesReference
stoichiometry: 1.0
species: 207448

250931
type: SpeciesReference
stoichiometry: 1.0
species: 207267

207833
type: Reaction
product: 254843
product: 254831
reactant: 254819
reactant: 254806
notes: GENE_ASSOCIATION: ( BCI_0073_purN ) PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase ) PROTEIN_CLASS: 2.1.2.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: tetrahydrofolate biosynthesis I COFACTOR: _10__45__FORMYL__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosylglycinamide formyltransferase

254843
type: SpeciesReference
stoichiometry: 1.0
species: 207258

254831
type: SpeciesReference
stoichiometry: 1.0
species: 207257

254819
type: SpeciesReference
stoichiometry: 1.0
species: 207255

254806
type: SpeciesReference
stoichiometry: 1.0
species: 207254

207754
type: Reaction
product: 251528
product: 251515
reactant: 251503
reactant: 251491
notes: GENE_ASSOCIATION: ( BCI_0028_murA ) PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 1-carboxyvinyltransferase ) PROTEIN_CLASS: 2.5.1.7 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

251528
type: SpeciesReference
stoichiometry: 1.0
species: 207309

251515
type: SpeciesReference
stoichiometry: 1.0
species: 207242

251503
type: SpeciesReference
stoichiometry: 1.0
species: 207349

251491
type: SpeciesReference
stoichiometry: 1.0
species: 207423

207604
type: Reaction
fast: false
product: 245359
reversible: false
reactant: 245323
product: 245347
name: Methionine adenosyltransferase
reactant: 245299
product: 245335
reactant: 245311
notes: GENE_ASSOCIATION: ( BCI_0015_metK ) PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT)//S-ADENMETSYN-RXN//Methionine adenosyltransferase ) PROTEIN_CLASS: 2.5.1.6 SUBSYSTEM: S-adenosyl-L-methionine cycle SUBSYSTEM: S-adenosylmethionine biosynthesis SIDE: ATP SIDE: WATER SIDE: PPI SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false

245359
type: SpeciesReference
stoichiometry: 1.0
species: 207242

245323
type: SpeciesReference
stoichiometry: 1.0
species: 207479

245347
type: SpeciesReference
stoichiometry: 1.0
species: 207460

245299
type: SpeciesReference
stoichiometry: 1.0
species: 207238

245335
type: SpeciesReference
stoichiometry: 1.0
species: 207280

245311
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207699
type: Reaction
product: 249313
reactant: 249301
notes: GENE_ASSOCIATION: ( BCI_0022_rpe ) PROTEIN_ASSOCIATION: ( ribulose-phosphate 3-epimerase ) PROTEIN_CLASS: 5.1.3.1 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (partial) SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: ribulose phosphate 3-epimerase

249313
type: SpeciesReference
stoichiometry: 1.0
species: 207340

249301
type: SpeciesReference
stoichiometry: 1.0
species: 207360

207583
type: Reaction
reversible: false
reactant: 244489
product: 244537
reactant: 244477
product: 244525
notes: GENE_ASSOCIATION: ( BCI_0183_dfp ) PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase ) PROTEIN_CLASS: 6.3.2.5 SUBSYSTEM: coenzyme A biosynthesis SIDE: CYS SIDE: CTP SIDE: PPI SIDE: CMP COFACTOR: CTP COFACTOR: PPI COFACTOR: CMP GENERIC: false TYPE: small HOLE: false
fast: false
product: 244513
name: Phosphopantothenate--cysteine ligase
reactant: 244501

244489
type: SpeciesReference
stoichiometry: 1.0
species: 207510

244537
type: SpeciesReference
stoichiometry: 1.0
species: 207288

244477
type: SpeciesReference
stoichiometry: 1.0
species: 207417

244525
type: SpeciesReference
stoichiometry: 1.0
species: 207280

244513
type: SpeciesReference
stoichiometry: 1.0
species: 207465

244501
type: SpeciesReference
stoichiometry: 1.0
species: 207312

207443
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: S-ribosyl-L-homocysteine

207829
type: Reaction
reversible: false
name: folylpolyglutamate synthetase
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate polyglutamylation I SIDE: ATP SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
reactant: 254601
reactant: 254613
reactant: 254625
product: 254649
product: 254637
fast: false
product: 254661

254601
type: SpeciesReference
stoichiometry: 1.0
species: 207238

254613
type: SpeciesReference
stoichiometry: 1.0
species: 207272

254625
type: SpeciesReference
stoichiometry: 1.0
species: 207273

254649
type: SpeciesReference
stoichiometry: 1.0
species: 207243

254637
type: SpeciesReference
stoichiometry: 1.0
species: 207272

254661
type: SpeciesReference
stoichiometry: 1.0
species: 207242

207629
type: Reaction
fast: false
notes: GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: 2.1.2.1 SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: glycine biosynthesis I SUBSYSTEM: superpathway of serine and glycine biosynthesis I SUBSYSTEM: folate polyglutamylation I SUBSYSTEM: folate transformations SIDE: WATER COFACTOR: THF COFACTOR: METHYLENE__45__THF GENERIC: false TYPE: small HOLE: false
product: 246434
reactant: 246410
product: 246446
product: 246422
reversible: true
name: glycine hydroxymethyltransferase
reactant: 246398

246434
type: SpeciesReference
stoichiometry: 1.0
species: 207265

246410
type: SpeciesReference
stoichiometry: 1.0
species: 207258

246446
type: SpeciesReference
stoichiometry: 1.0
species: 207314

246422
type: SpeciesReference
stoichiometry: 1.0
species: 207389

246398
type: SpeciesReference
stoichiometry: 1.0
species: 207338

207743
type: Reaction
product: 251065
product: 251053
reactant: 251041
reactant: 251029
notes: GENE_ASSOCIATION: ( BCI_0224_pfs ) PROTEIN_ASSOCIATION: ( MTA/SAH nucleosidase ) PROTEIN_CLASS: 3.2.2.9 GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Adenosylhomocysteine nucleosidase

251065
type: SpeciesReference
stoichiometry: 1.0
species: 207444

207444
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: adenine

251053
type: SpeciesReference
stoichiometry: 1.0
species: 207443

251041
type: SpeciesReference
stoichiometry: 1.0
species: 207442

251029
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207611
type: Reaction
product: 245709
product: 245697
reactant: 245685
reactant: 245673
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

245709
type: SpeciesReference
stoichiometry: 1.0
species: 207555

245697
type: SpeciesReference
stoichiometry: 1.0
species: 207243

245685
type: SpeciesReference
stoichiometry: 1.0
species: 207438

245673
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207793
type: Reaction
reversible: false
product: 253178
product: 253166
fast: false
notes: GENE_ASSOCIATION: ( BCI_0173_gpsA ) PROTEIN_ASSOCIATION: ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN ) PROTEIN_CLASS: 1.1.1.94 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SUBSYSTEM: CDP-diacylglycerol biosynthesis I SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
reactant: 253154
name: Glycerol-3-phosphate dehydrogenase (NAD(P)+)
reactant: 253130
reactant: 253142

253178
type: SpeciesReference
stoichiometry: 1.0
species: 207285

253166
type: SpeciesReference
stoichiometry: 1.0
species: 207270

253154
type: SpeciesReference
stoichiometry: 1.0
species: 207268

253130
type: SpeciesReference
stoichiometry: 1.0
species: 207267

253142
type: SpeciesReference
stoichiometry: 1.0
species: 207352

207809
type: Reaction
product: 253878
product: 253866
reactant: 253854
reactant: 253842
notes: GENE_ASSOCIATION: ( BCI_0533_cdsA ) PROTEIN_ASSOCIATION: ( phosphatidate cytidylyltransferase ) PROTEIN_CLASS: 2.7.7.41 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SUBSYSTEM: CDP-diacylglycerol biosynthesis I SIDE: CTP SIDE: PPI GENERIC: true TYPE: small HOLE: false
fast: false
reversible: false
name: phosphatidate cytidylyltransferase

253878
type: SpeciesReference
stoichiometry: 1.0
species: 207284

253866
type: SpeciesReference
stoichiometry: 1.0
species: 207280

253854
type: SpeciesReference
stoichiometry: 1.0
species: 207313

253842
type: SpeciesReference
stoichiometry: 1.0
species: 207312

207661
type: Reaction
product: 247921
product: 247909
reactant: 247897
notes: GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA GENERIC: true TYPE: small HOLE: false
fast: false
reversible: true
name: NA

247921
type: SpeciesReference
stoichiometry: 1.0
species: 207528

247909
type: SpeciesReference
stoichiometry: 1.0
species: 207314

247897
type: SpeciesReference
stoichiometry: 1.0
species: 207527

207527
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: allothreonine

207768
type: Reaction
product: 252080
product: 252068
reactant: 252056
reactant: 252044
notes: GENE_ASSOCIATION: ( BCI_0211_ispD ) PROTEIN_ASSOCIATION: ( 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ) PROTEIN_CLASS: 2.7.7.60 SUBSYSTEM: methylerythritol phosphate pathway SIDE: CTP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

252080
type: SpeciesReference
stoichiometry: 1.0
species: 207280

252068
type: SpeciesReference
stoichiometry: 1.0
species: 207405

252056
type: SpeciesReference
stoichiometry: 1.0
species: 207312

252044
type: SpeciesReference
stoichiometry: 1.0
species: 207404

207404
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: 2-C-methyl-D-erythritol-4-phosphate

207618
type: Reaction
product: 245938
product: 245926
reactant: 245914
notes: GENE_ASSOCIATION: ( BCI_0602_ribH ) or ( BCI_0087_ribE ) PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase ) or ( riboflavin synthase subunit alpha ) PROTEIN_CLASS: 2.5.1.9 SUBSYSTEM: flavin biosynthesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Riboflavin synthase

245938
type: SpeciesReference
stoichiometry: 1.0
species: 207492

245926
type: SpeciesReference
stoichiometry: 1.0
species: 207507

245914
type: SpeciesReference
stoichiometry: 2.0
species: 207508

207400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: succinyl-CoA

207599
type: Reaction
product: 245167
product: 245155
reactant: 245143
notes: GENE_ASSOCIATION: ( BCI_0298_pyrF ) PROTEIN_ASSOCIATION: ( orotidine 5'-phosphate decarboxylase//OROTPDECARB-RXN ) PROTEIN_CLASS: 4.1.1.23 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Orotidine-5'-phosphate decarboxylase

245167
type: SpeciesReference
stoichiometry: 1.0
species: 207359

245155
type: SpeciesReference
stoichiometry: 1.0
species: 207329

245143
type: SpeciesReference
stoichiometry: 1.0
species: 207282

207586
type: Reaction
product: 244646
product: 244633
reactant: 244621
reactant: 244609
notes: GENE_ASSOCIATION: ( BCI_0409_pyrD ) PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase 2//DIHYDROOROTOX-RXN ) PROTEIN_CLASS: 1.3.3.1 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Dihydroorotate oxidase

244646
type: SpeciesReference
stoichiometry: 1.0
species: 207279

244633
type: SpeciesReference
stoichiometry: 1.0
species: 207324

244621
type: SpeciesReference
stoichiometry: 1.0
species: 207557

244609
type: SpeciesReference
stoichiometry: 1.0
species: 207323

207709
type: Reaction
name: NA
reactant: 249714
fast: false
reactant: 249702
product: 249738
product: 249726
notes: GENE_ASSOCIATION: ( BCI_0102_nadA ) PROTEIN_ASSOCIATION: ( quinolinate synthetase ) PROTEIN_CLASS: NA SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reversible: false
product: 249750

249714
type: SpeciesReference
stoichiometry: 1.0
species: 207352

249702
type: SpeciesReference
stoichiometry: 1.0
species: 207459

249738
type: SpeciesReference
stoichiometry: 1.0
species: 207242

249726
type: SpeciesReference
stoichiometry: 2.0
species: 207265

249750
type: SpeciesReference
stoichiometry: 1.0
species: 207452

207735
type: Reaction
product: 250775
product: 250763
reactant: 250751
notes: GENE_ASSOCIATION: ( BCI_0593_aspA ) PROTEIN_ASSOCIATION: ( aspartate ammonia-lyase ) PROTEIN_CLASS: 4.3.1.1 SUBSYSTEM: glutamate degradation II SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aspartate ammonia-lyase

250775
type: SpeciesReference
stoichiometry: 1.0
species: 207293

250763
type: SpeciesReference
stoichiometry: 1.0
species: 207308

250751
type: SpeciesReference
stoichiometry: 1.0
species: 207383

207603
type: Reaction
product: 245287
product: 245275
reactant: 245263
notes: GENE_ASSOCIATION: ( BCI_0035_purH ) PROTEIN_ASSOCIATION: ( bifunctional purine biosynthesis protein PurH ) PROTEIN_CLASS: 3.5.4.10 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: IMP cyclohydrolase

245287
type: SpeciesReference
stoichiometry: 1.0
species: 207382

245275
type: SpeciesReference
stoichiometry: 1.0
species: 207265

245263
type: SpeciesReference
stoichiometry: 1.0
species: 207509

207803
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0523_murE ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN ) SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP PROTEIN_CLASS: 6.3.2.13 GENERIC: true TYPE: small HOLE: false
reactant: 253528
product: 253564
reversible: false
reactant: 253552
product: 253576
name: UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
reactant: 253540
fast: false
product: 253588

253528
type: SpeciesReference
stoichiometry: 1.0
species: 207337

253564
type: SpeciesReference
stoichiometry: 1.0
species: 207330

253552
type: SpeciesReference
stoichiometry: 1.0
species: 207235

253576
type: SpeciesReference
stoichiometry: 1.0
species: 207242

253540
type: SpeciesReference
stoichiometry: 1.0
species: 207238

253588
type: SpeciesReference
stoichiometry: 1.0
species: 207243

207785
type: Reaction
product: 252817
product: 252805
reactant: 252793
reactant: 252781
notes: GENE_ASSOCIATION: ( BCI_0274_ispA ) PROTEIN_ASSOCIATION: ( geranyltranstransferase//FPPSYN-RXN ) PROTEIN_CLASS: 2.5.1.10 SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: geranyltranstransferase

252817
type: SpeciesReference
stoichiometry: 1.0
species: 207280

252805
type: SpeciesReference
stoichiometry: 1.0
species: 207369

252793
type: SpeciesReference
stoichiometry: 1.0
species: 207368

252781
type: SpeciesReference
stoichiometry: 1.0
species: 207294

207653
type: Reaction
product: 247448
name: NA
notes: GENE_ASSOCIATION: ( BCI_0601_ribD ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibD//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN ) PROTEIN_CLASS: 1.1.1.193 SUBSYSTEM: flavin biosynthesis SIDE: NADPH SIDE: PROTON SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
reactant: 247436
product: 247460
reactant: 247424
reactant: 247412
fast: false
reversible: false

247448
type: SpeciesReference
stoichiometry: 1.0
species: 207531

247436
type: SpeciesReference
stoichiometry: 1.0
species: 207267

247460
type: SpeciesReference
stoichiometry: 1.0
species: 207275

247424
type: SpeciesReference
stoichiometry: 1.0
species: 207274

247412
type: SpeciesReference
stoichiometry: 1.0
species: 207394

207726
type: Reaction
product: 250378
product: 250366
reactant: 250354
reactant: 250342
notes: GENE_ASSOCIATION: ( BCI_0254_cmk ) or ( BCI_0529_pyrH ) PROTEIN_ASSOCIATION: ( cytidylate kinase ) or ( uridylate kinase ) PROTEIN_CLASS: 2.7.4.14 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

250378
type: SpeciesReference
stoichiometry: 1.0
species: 207243

250366
type: SpeciesReference
stoichiometry: 1.0
species: 207425

250354
type: SpeciesReference
stoichiometry: 1.0
species: 207238

250342
type: SpeciesReference
stoichiometry: 1.0
species: 207329

207813
type: Reaction
product: 254012
product: 254000
reactant: 253987
reactant: 253975
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

254012
type: SpeciesReference
stoichiometry: 1.0
species: 207304

254000
type: SpeciesReference
stoichiometry: 1.0
species: 207280

253987
type: SpeciesReference
stoichiometry: 1.0
species: 207294

253975
type: SpeciesReference
stoichiometry: 1.0
species: 207305

207305
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: di-trans,poly-cis-nonaprenyl diphosphate

207769
type: Reaction
product: 252128
product: 252116
reactant: 252104
reactant: 252092
notes: GENE_ASSOCIATION: ( BCI_0019_metA ) PROTEIN_ASSOCIATION: ( homoserine O-succinyltransferase ) PROTEIN_CLASS: 2.3.1.46 SUBSYSTEM: methionine biosynthesis I SIDE: SUC__45__COA SIDE: CO__45__A COFACTOR: SUC__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Homoserine O-succinyltransferase

252128
type: SpeciesReference
stoichiometry: 1.0
species: 207310

252116
type: SpeciesReference
stoichiometry: 1.0
species: 207403

252104
type: SpeciesReference
stoichiometry: 1.0
species: 207402

252092
type: SpeciesReference
stoichiometry: 1.0
species: 207400

207645
type: Reaction
product: 247120
product: 247107
reactant: 247095
reactant: 247083
notes: GENE_ASSOCIATION: ( BCI_0163_metB ) PROTEIN_ASSOCIATION: ( O-succinylhomoserine (thiol)-lyase//METBALT-RXN//O-SUCCHOMOSERLYASE-RXN ) PROTEIN_CLASS: 2.5.1.48 SUBSYSTEM: methionine biosynthesis I SIDE: CYS SIDE: SUC GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: O-succinylhomoserine (thiol)-lyase

247120
type: SpeciesReference
stoichiometry: 1.0
species: 207415

247107
type: SpeciesReference
stoichiometry: 1.0
species: 207290

247095
type: SpeciesReference
stoichiometry: 1.0
species: 207417

247083
type: SpeciesReference
stoichiometry: 1.0
species: 207403

207650
type: Reaction
product: 247338
product: 247326
reactant: 247314
reactant: 247302
notes: GENE_ASSOCIATION: ( BCI_0172_cysE ) PROTEIN_ASSOCIATION: ( serine acetyltransferase//SERINE-O-ACETTRAN-RXN ) PROTEIN_CLASS: 2.3.1.30 SUBSYSTEM: superpathway of cysteine biosynthesis SUBSYSTEM: cysteine biosynthesis I SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Serine O-acetyltransferase

247338
type: SpeciesReference
stoichiometry: 1.0
species: 207532

247326
type: SpeciesReference
stoichiometry: 1.0
species: 207310

247314
type: SpeciesReference
stoichiometry: 1.0
species: 207485

247302
type: SpeciesReference
stoichiometry: 1.0
species: 207338

207517
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dCDP

207730
type: Reaction
product: 250570
reactant: 250522
name: phosphoribosylformylglycinamidine synthetase
product: 250582
fast: false
product: 250546
reversible: false
reactant: 250498
reactant: 250534
product: 250558
reactant: 250510
notes: GENE_ASSOCIATION: ( BCI_0002_purL ) PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamidine synthase ) PROTEIN_CLASS: 6.3.5.3 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER SIDE: GLN SIDE: GLT SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false

250570
type: SpeciesReference
stoichiometry: 1.0
species: 207243

250522
type: SpeciesReference
stoichiometry: 1.0
species: 207372

250582
type: SpeciesReference
stoichiometry: 1.0
species: 207242

250546
type: SpeciesReference
stoichiometry: 1.0
species: 207273

250498
type: SpeciesReference
stoichiometry: 1.0
species: 207265

250534
type: SpeciesReference
stoichiometry: 1.0
species: 207257

250558
type: SpeciesReference
stoichiometry: 1.0
species: 207283

250510
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207788
type: Reaction
product: 252949
reactant: 252913
name: Pantoate--&beta;-alanine ligase
reversible: false
reactant: 252901
product: 252937
notes: GENE_ASSOCIATION: ( BCI_0231_panC ) PROTEIN_ASSOCIATION: ( Pantothenate synthetase (PS) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase ) PROTEIN_CLASS: 6.3.2.1 SUBSYSTEM: pantothenate biosynthesis I SIDE: ATP SIDE: PPI SIDE: AMP COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
fast: false
reactant: 252889
product: 252925

252949
type: SpeciesReference
stoichiometry: 1.0
species: 207365

252913
type: SpeciesReference
stoichiometry: 1.0
species: 207238

252901
type: SpeciesReference
stoichiometry: 1.0
species: 207363

252937
type: SpeciesReference
stoichiometry: 1.0
species: 207364

252889
type: SpeciesReference
stoichiometry: 1.0
species: 207362

252925
type: SpeciesReference
stoichiometry: 1.0
species: 207280

207588
type: Reaction
product: 244682
product: 244670
reactant: 244658
notes: GENE_ASSOCIATION: ( BCI_0361_aroC ) PROTEIN_ASSOCIATION: ( Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase)//CHORISMATE-SYNTHASE-RXN//Chorismate synthase ) PROTEIN_CLASS: 4.2.3.5 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Chorismate synthase

244682
type: SpeciesReference
stoichiometry: 1.0
species: 207468

244670
type: SpeciesReference
stoichiometry: 1.0
species: 207242

244658
type: SpeciesReference
stoichiometry: 1.0
species: 207512

207718
type: Reaction
product: 250052
product: 250040
reactant: 250028
reactant: 250016
notes: GENE_ASSOCIATION: ( BCI_0310_pykA ) PROTEIN_ASSOCIATION: ( pyruvate kinase ) PROTEIN_CLASS: 2.7.1.40 SUBSYSTEM: glycolysis I SUBSYSTEM: mixed acid fermentation SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SIDE: ADP SIDE: ATP COFACTOR: ADP COFACTOR: ATP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Pyruvate kinase

250052
type: SpeciesReference
stoichiometry: 1.0
species: 207259

250040
type: SpeciesReference
stoichiometry: 1.0
species: 207238

250028
type: SpeciesReference
stoichiometry: 1.0
species: 207349

250016
type: SpeciesReference
stoichiometry: 1.0
species: 207243

207675
type: Reaction
product: 248395
product: 248383
reactant: 248371
reactant: 248359
notes: GENE_ASSOCIATION: ( BCI_0171_pfkA ) PROTEIN_ASSOCIATION: ( 6-phosphofructokinase//6PFRUCTPHOS-RXN ) PROTEIN_CLASS: 2.7.1.11 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 6-phosphofructokinase

248395
type: SpeciesReference
stoichiometry: 1.0
species: 207243

248383
type: SpeciesReference
stoichiometry: 1.0
species: 207514

248371
type: SpeciesReference
stoichiometry: 1.0
species: 207379

248359
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207570
type: Reaction
reversible: false
product: 243910
reactant: 243898
product: 243922
fast: false
product: 243934
name: NA
notes: GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides PROTEIN_CLASS: 1.17.4.1 COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ SIDE: WATER SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
reactant: 243886

243910
type: SpeciesReference
stoichiometry: 1.0
species: 207562

243898
type: SpeciesReference
stoichiometry: 1.0
species: 207561

243922
type: SpeciesReference
stoichiometry: 1.0
species: 207265

243934
type: SpeciesReference
stoichiometry: 1.0
species: 207517

243886
type: SpeciesReference
stoichiometry: 1.0
species: 207289

207598
type: Reaction
product: 245131
product: 245119
reactant: 245106
reactant: 245094
notes: GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 1.3.1.76 SUBSYSTEM: siroheme biosynthesis SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

245131
type: SpeciesReference
stoichiometry: 1.0
species: 207489

245119
type: SpeciesReference
stoichiometry: 1.0
species: 207253

245106
type: SpeciesReference
stoichiometry: 1.0
species: 207547

245094
type: SpeciesReference
stoichiometry: 1.0
species: 207250

207634
type: Reaction
reactant: 246628
name: Acetyl-CoA carboxylase
product: 246664
reversible: false
product: 246676
reactant: 246640
fast: false
reactant: 246603
notes: GENE_ASSOCIATION: ( BCI_0365_accD ) or ( BCI_0052_accC ) or ( BCI_0051_accB ) or ( BCI_0539_accA ) PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase, carboxyl transferase, beta subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) or ( acetyl-CoA carboxylase biotin carboxylase subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN ) or ( acetyl-CoA carboxylase, biotin carboxyl carrier protein ) or ( acetyl-CoA carboxylase, carboxyl transferase, alpha subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) PROTEIN_CLASS: 6.4.1.2 SUBSYSTEM: fatty acid biosynthesis - initial steps I SUBSYSTEM: superpathway of fatty acid biosynthesis SIDE: ATP SIDE: HCO3 SIDE: PROTON SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
product: 246652
reactant: 246616

246628
type: SpeciesReference
stoichiometry: 1.0
species: 207248

246664
type: SpeciesReference
stoichiometry: 1.0
species: 207243

246676
type: SpeciesReference
stoichiometry: 1.0
species: 207242

246640
type: SpeciesReference
stoichiometry: 1.0
species: 207267

246603
type: SpeciesReference
stoichiometry: 1.0
species: 207238

246652
type: SpeciesReference
stoichiometry: 1.0
species: 207546

246616
type: SpeciesReference
stoichiometry: 1.0
species: 207485

207700
type: Reaction
product: 249361
product: 249349
reactant: 249337
reactant: 249325
notes: GENE_ASSOCIATION: ( BCI_0555_ribF ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibF ) PROTEIN_CLASS: 2.7.1.26 SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis SUBSYSTEM: flavin biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Riboflavin kinase

249361
type: SpeciesReference
stoichiometry: 1.0
species: 207320

249349
type: SpeciesReference
stoichiometry: 1.0
species: 207243

249337
type: SpeciesReference
stoichiometry: 1.0
species: 207492

249325
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207684
type: Reaction
product: 248782
product: 248770
reactant: 248758
reactant: 248745
notes: GENE_ASSOCIATION: ( BCI_0531_dxr ) PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose 5-phosphate reductoisomerase//DXPREDISOM-RXN ) PROTEIN_CLASS: 1.1.1.267 SUBSYSTEM: methylerythritol phosphate pathway SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

248782
type: SpeciesReference
stoichiometry: 1.0
species: 207275

248770
type: SpeciesReference
stoichiometry: 1.0
species: 207404

248758
type: SpeciesReference
stoichiometry: 1.0
species: 207274

248745
type: SpeciesReference
stoichiometry: 1.0
species: 207422

207750
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0073_purN ) PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase ) PROTEIN_CLASS: 2.1.2.- SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: FORMATE SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 251330
reactant: 251318
reactant: 251343
product: 251355
name: NA
fast: false
reversible: false
product: 251367
product: 251379

251330
type: SpeciesReference
stoichiometry: 1.0
species: 207238

251318
type: SpeciesReference
stoichiometry: 1.0
species: 207328

251343
type: SpeciesReference
stoichiometry: 1.0
species: 207254

251355
type: SpeciesReference
stoichiometry: 1.0
species: 207243

251367
type: SpeciesReference
stoichiometry: 1.0
species: 207242

251379
type: SpeciesReference
stoichiometry: 1.0
species: 207257

207814
type: Reaction
product: 254060
product: 254048
reactant: 254036
reactant: 254024
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

254060
type: SpeciesReference
stoichiometry: 1.0
species: 207280

254048
type: SpeciesReference
stoichiometry: 1.0
species: 207305

254036
type: SpeciesReference
stoichiometry: 1.0
species: 207294

254024
type: SpeciesReference
stoichiometry: 1.0
species: 207298

207659
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0288_nadE ) PROTEIN_ASSOCIATION: ( NAD synthetase//NAD-SYNTH-NH3-RXN ) PROTEIN_CLASS: 6.3.5.1 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: GLN SIDE: WATER SIDE: ATP SIDE: AMP SIDE: GLT SIDE: PPI COFACTOR: ATP COFACTOR: AMP COFACTOR: PPI GENERIC: false TYPE: small HOLE: false
name: NAD(+) synthetase (glutamine-hydrolysing)
fast: false
reactant: 247764
reactant: 247752
reactant: 247740
reactant: 247727
product: 247788
product: 247812
product: 247776
product: 247800

247764
type: SpeciesReference
stoichiometry: 1.0
species: 207319

247752
type: SpeciesReference
stoichiometry: 1.0
species: 207238

247740
type: SpeciesReference
stoichiometry: 1.0
species: 207265

247727
type: SpeciesReference
stoichiometry: 1.0
species: 207372

247788
type: SpeciesReference
stoichiometry: 1.0
species: 207365

247812
type: SpeciesReference
stoichiometry: 1.0
species: 207280

247776
type: SpeciesReference
stoichiometry: 1.0
species: 207250

247800
type: SpeciesReference
stoichiometry: 1.0
species: 207273

207715
type: Reaction
notes: GENE_ASSOCIATION: ( BCI_0368_purF ) PROTEIN_ASSOCIATION: ( amidophosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.14 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: GLN SIDE: WATER SIDE: PPI SIDE: GLT GENERIC: false TYPE: small HOLE: false
name: Amidophosphoribosyltransferase
reactant: 249932
reactant: 249908
reactant: 249920
reversible: false
product: 249944
product: 249956
product: 249968
fast: false

249932
type: SpeciesReference
stoichiometry: 1.0
species: 207265

249908
type: SpeciesReference
stoichiometry: 1.0
species: 207278

249920
type: SpeciesReference
stoichiometry: 1.0
species: 207372

249944
type: SpeciesReference
stoichiometry: 1.0
species: 207280

249956
type: SpeciesReference
stoichiometry: 1.0
species: 207273

249968
type: SpeciesReference
stoichiometry: 1.0
species: 207315

207626
type: Reaction
reversible: false
product: 246326
reactant: 246253
reactant: 246265
reactant: 246289
fast: false
product: 246301
product: 246314
notes: GENE_ASSOCIATION: ( BCI_0559_carA ) or ( BCI_0560_carB ) PROTEIN_ASSOCIATION: ( carbamoyl-phosphate synthase, small subunit//CARBPSYN-RXN ) or ( carbamoyl-phosphate synthase, large subunit//CARBPSYN-RXN ) PROTEIN_CLASS: 6.3.5.5 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: WATER SIDE: ATP SIDE: GLN SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
name: carbamoyl-phosphate synthetase (glutamine-hydrolysing)
reactant: 246277
product: 246338

246326
type: SpeciesReference
stoichiometry: 1.0
species: 207434

207434
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: carbamoyl-phosphate

246253
type: SpeciesReference
stoichiometry: 1.0
species: 207265

246265
type: SpeciesReference
stoichiometry: 2.0
species: 207238

246289
type: SpeciesReference
stoichiometry: 1.0
species: 207248

246301
type: SpeciesReference
stoichiometry: 1.0
species: 207273

246314
type: SpeciesReference
stoichiometry: 2.0
species: 207243

246277
type: SpeciesReference
stoichiometry: 1.0
species: 207372

246338
type: SpeciesReference
stoichiometry: 1.0
species: 207242

207676
type: Reaction
product: 248443
product: 248431
reactant: 248419
reactant: 248407
notes: GENE_ASSOCIATION: ( BCI_0139_glmU ) PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P- ) PROTEIN_CLASS: 2.3.1.157 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Glucosamine-1-phosphate N-acetyltransferase

248443
type: SpeciesReference
stoichiometry: 1.0
species: 207447

248431
type: SpeciesReference
stoichiometry: 1.0
species: 207310

248419
type: SpeciesReference
stoichiometry: 1.0
species: 207513

248407
type: SpeciesReference
stoichiometry: 1.0
species: 207485

207571
type: Reaction
product: 243982
product: 243970
reactant: 243958
reactant: 243946
notes: SUBSYSTEM: geranyldiphosphate biosynthesis SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP) SUBSYSTEM: superpathway of cholesterol biosynthesis SUBSYSTEM: superpathway of ergosterol biosynthesis SUBSYSTEM: polyisoprenoid biosynthesis (E. coli) SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PROTEIN_CLASS: 2.5.1.1 SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dimethylallyltransferase

243982
type: SpeciesReference
stoichiometry: 1.0
species: 207368

243970
type: SpeciesReference
stoichiometry: 1.0
species: 207280

243958
type: SpeciesReference
stoichiometry: 1.0
species: 207294

243946
type: SpeciesReference
stoichiometry: 1.0
species: 207269

207569
type: Reaction
reactant: 243826
notes: GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) PROTEIN_CLASS: 1.17.4.1 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides PROTEIN_CLASS: 1.17.4.1 COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ SIDE: WATER SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
name: NA
reversible: false
product: 243874
product: 243850
reactant: 243838
product: 243862
fast: false

243826
type: SpeciesReference
stoichiometry: 1.0
species: 207425

243874
type: SpeciesReference
stoichiometry: 1.0
species: 207562

243850
type: SpeciesReference
stoichiometry: 1.0
species: 207450

243838
type: SpeciesReference
stoichiometry: 1.0
species: 207561

243862
type: SpeciesReference
stoichiometry: 1.0
species: 207265

207836
type: Reaction
product: 255002
reactant: 254990
notes: GENE_ASSOCIATION: ( BCI_0120_purE ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase, catalytic subunit ) PROTEIN_CLASS: NA SUBSYSTEM: purine nucleotides de novo biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

255002
type: SpeciesReference
stoichiometry: 1.0
species: 207245

254990
type: SpeciesReference
stoichiometry: 1.0
species: 207244

207683
type: Reaction
product: 248733
product: 248721
reactant: 248709
reactant: 248697
notes: GENE_ASSOCIATION: ( BCI_0035_purH ) PROTEIN_ASSOCIATION: ( bifunctional purine biosynthesis protein PurH ) PROTEIN_CLASS: 2.1.2.3 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: _10__45__FORMYL__45__THF SIDE: THF COFACTOR: _10__45__FORMYL__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosylaminoimidazolecarboxamide formyltransferase

248733
type: SpeciesReference
stoichiometry: 1.0
species: 207509

248721
type: SpeciesReference
stoichiometry: 1.0
species: 207258

248709
type: SpeciesReference
stoichiometry: 1.0
species: 207255

248697
type: SpeciesReference
stoichiometry: 1.0
species: 207454

207745
type: Reaction
product: 251161
product: 251149
reactant: 251137
reactant: 251125
notes: GENE_ASSOCIATION: ( BCI_0431_tmk ) PROTEIN_ASSOCIATION: ( thymidylate kinase//DTMPKI-RXN ) PROTEIN_CLASS: 2.7.4.9 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Thymidylate kinase

251161
type: SpeciesReference
stoichiometry: 1.0
species: 207438

251149
type: SpeciesReference
stoichiometry: 1.0
species: 207243

251137
type: SpeciesReference
stoichiometry: 1.0
species: 207238

251125
type: SpeciesReference
stoichiometry: 1.0
species: 207437

207437
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 207233
name: dTMP

207613
type: Reaction
product: 245757
product: 245745
reactant: 245733
reactant: 245721
notes: GENE_ASSOCIATION: ( BCI_0564_pdxA ) PROTEIN_ASSOCIATION: ( 4-hydroxythreonine-4-phosphate dehydrogenase ) PROTEIN_CLASS: 1.1.1.262 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 4-hydroxythreonine-4-phosphate dehydrogenase

245757
type: SpeciesReference
stoichiometry: 1.0
species: 207253

245745
type: SpeciesReference
stoichiometry: 1.0
species: 207448

245733
type: SpeciesReference
stoichiometry: 1.0
species: 207553

245721
type: SpeciesReference
stoichiometry: 1.0
species: 207250

207691
type: Reaction
product: 249082
product: 249070
reactant: 249058
reactant: 249046
notes: GENE_ASSOCIATION: ( BCI_0001_mqo ) PROTEIN_ASSOCIATION: ( malate:quinone oxidoreductase//MALATE-DEHYDROGENASE-(ACCEPTOR)-RXN ) PROTEIN_CLASS: 1.1.99.16 SUBSYSTEM: TCA cycle variation II SIDE: VITAMIN_K_2 SIDE: REDUCED__45__MENAQUINONE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

249082
type: SpeciesReference
stoichiometry: 1.0
species: 207500

249070
type: SpeciesReference
stoichiometry: 1.0
species: 207395

249058
type: SpeciesReference
stoichiometry: 1.0
species: 207499

249046
type: SpeciesReference
stoichiometry: 1.0
species: 207307

207753
type: Reaction
fast: false
notes: GENE_ASSOCIATION: ( BCI_0388_ddlA ) PROTEIN_ASSOCIATION: ( D-ala D-ala ligase ) PROTEIN_CLASS: 6.3.2.4 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 251429
product: 251454
product: 251478
product: 251466
reversible: false
name: D-alanine--D-alanine ligase
reactant: 251442

251429
type: SpeciesReference
stoichiometry: 1.0
species: 207238

251454
type: SpeciesReference
stoichiometry: 1.0
species: 207332

251478
type: SpeciesReference
stoichiometry: 1.0
species: 207242

251466
type: SpeciesReference
stoichiometry: 1.0
species: 207243

251442
type: SpeciesReference
stoichiometry: 2.0
species: 207430

207821
type: Reaction
product: 254325
product: 254313
reactant: 254301
reactant: 254289
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

254325
type: SpeciesReference
stoichiometry: 1.0
species: 207280

254313
type: SpeciesReference
stoichiometry: 1.0
species: 207297

254301
type: SpeciesReference
stoichiometry: 1.0
species: 207295

254289
type: SpeciesReference
stoichiometry: 1.0
species: 207294

207621
type: Reaction
product: 246083
reactant: 246071
notes: GENE_ASSOCIATION: ( BCI_0636_glmM ) PROTEIN_ASSOCIATION: ( Phosphoglucosamine mutase//5.4.2.10-RXN//Phosphoglucosamine mutase ) PROTEIN_CLASS: 5.4.2.10 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoglucosamine mutase

246083
type: SpeciesReference
stoichiometry: 1.0
species: 207513

246071
type: SpeciesReference
stoichiometry: 1.0
species: 207548

207698
type: Reaction
product: 249289
product: 249277
reactant: 249265
reactant: 249253
notes: GENE_ASSOCIATION: ( BCI_0042_thiE ) PROTEIN_ASSOCIATION: ( thiamine-phosphate pyrophosphorylase//THI-P-SYN-RXN ) PROTEIN_CLASS: 2.5.1.3 SUBSYSTEM: thiamine biosynthesis SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Thiamine-phosphate pyrophosphorylase

249289
type: SpeciesReference
stoichiometry: 1.0
species: 207495

249277
type: SpeciesReference
stoichiometry: 1.0
species: 207280

249265
type: SpeciesReference
stoichiometry: 1.0
species: 207494

249253
type: SpeciesReference
stoichiometry: 1.0
species: 207493

207764
type: Reaction
product: 251932
product: 251920
reactant: 251908
notes: GENE_ASSOCIATION: ( BCI_0432_pabC ) PROTEIN_ASSOCIATION: ( 4-amino-4-deoxychorismate lyase ) PROTEIN_CLASS: 4.1.3.38 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: PYRUVATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aminodeoxychorismate lyase

251932
type: SpeciesReference
stoichiometry: 1.0
species: 207259

251920
type: SpeciesReference
stoichiometry: 1.0
species: 207410

251908
type: SpeciesReference
stoichiometry: 1.0
species: 207409

207801
type: Reaction
reactant: 253468
product: 253492
reactant: 253480
reversible: false
notes: GENE_ASSOCIATION: ( BCI_0522_murF ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase//UDP-NACMURALGLDAPAALIG-RXN ) PROTEIN_CLASS: 6.3.2.10 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
reactant: 253456
name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase
product: 253516
fast: false
product: 253504

253468
type: SpeciesReference
stoichiometry: 1.0
species: 207330

253492
type: SpeciesReference
stoichiometry: 1.0
species: 207333

253480
type: SpeciesReference
stoichiometry: 1.0
species: 207332

253456
type: SpeciesReference
stoichiometry: 1.0
species: 207238

253516
type: SpeciesReference
stoichiometry: 1.0
species: 207243

253504
type: SpeciesReference
stoichiometry: 1.0
species: 207242

207609
type: Reaction
reversible: false
name: UDP-N-acetylmuramoylalanine--D-glutamate ligase
reactant: 245564
product: 245588
product: 245600
reactant: 245552
product: 245612
notes: GENE_ASSOCIATION: ( BCI_0520_murD ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanine--D-glutamate ligase (UDP-N- acetylmuramoyl-L-alanyl-D-glutamate synthetase) (D-glutamic acid- adding enzyme)//UDP-NACMURALA-GLU-LIG-RXN ) PROTEIN_CLASS: 6.3.2.9 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reactant: 245576

245564
type: SpeciesReference
stoichiometry: 1.0
species: 207240

245588
type: SpeciesReference
stoichiometry: 1.0
species: 207243

245600
type: SpeciesReference
stoichiometry: 1.0
species: 207242

245552
type: SpeciesReference
stoichiometry: 1.0
species: 207556

245612
type: SpeciesReference
stoichiometry: 1.0
species: 207337

245576
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207778
type: Reaction
product: 252517
fast: false
name: adenylosuccinate synthetase
reactant: 252480
reversible: false
reactant: 252468
product: 252505
product: 252493
reactant: 252456
notes: GENE_ASSOCIATION: ( BCI_0577_purA ) PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase//ADENYLOSUCCINATE-SYNTHASE-RXN ) PROTEIN_CLASS: 6.3.4.4 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ COFACTOR: GTP COFACTOR: GDP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false

252517
type: SpeciesReference
stoichiometry: 1.0
species: 207385

252480
type: SpeciesReference
stoichiometry: 1.0
species: 207383

252468
type: SpeciesReference
stoichiometry: 1.0
species: 207382

252505
type: SpeciesReference
stoichiometry: 1.0
species: 207242

252493
type: SpeciesReference
stoichiometry: 1.0
species: 207384

252456
type: SpeciesReference
stoichiometry: 1.0
species: 207380

207828
type: Reaction
product: 254589
product: 254577
reactant: 254565
reactant: 254553
notes: GENE_ASSOCIATION: ( BCI_0181_pyrE ) PROTEIN_ASSOCIATION: ( orotate phosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.10 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Orotate phosphoribosyltransferase

254589
type: SpeciesReference
stoichiometry: 1.0
species: 207282

254577
type: SpeciesReference
stoichiometry: 1.0
species: 207280

254565
type: SpeciesReference
stoichiometry: 1.0
species: 207279

254553
type: SpeciesReference
stoichiometry: 1.0
species: 207278

207628
type: Reaction
product: 246386
product: 246374
reactant: 246362
reactant: 246350
notes: GENE_ASSOCIATION: ( BCI_0138_glmS ) PROTEIN_ASSOCIATION: ( glucosamine--fructose-6-phosphate aminotransferase, isomerizing//L-GLN-FRUCT-6-P-AMINOTRANS-RXN ) PROTEIN_CLASS: 2.6.1.16 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)

246386
type: SpeciesReference
stoichiometry: 1.0
species: 207548

246374
type: SpeciesReference
stoichiometry: 1.0
species: 207273

246362
type: SpeciesReference
stoichiometry: 1.0
species: 207379

246350
type: SpeciesReference
stoichiometry: 1.0
species: 207372

207773
type: Reaction
name: Phosphoenolpyruvate carboxykinase (ATP)
product: 252286
product: 252262
reactant: 252238
product: 252274
fast: false
notes: GENE_ASSOCIATION: ( BCI_0013_pckA ) PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxykinase ) PROTEIN_CLASS: 4.1.1.49 SUBSYSTEM: gluconeogenesis SIDE: ATP SIDE: CARBON__45__DIOXIDE SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
reversible: false
reactant: 252250

252286
type: SpeciesReference
stoichiometry: 1.0
species: 207349

252262
type: SpeciesReference
stoichiometry: 1.0
species: 207359

252238
type: SpeciesReference
stoichiometry: 1.0
species: 207238

252274
type: SpeciesReference
stoichiometry: 1.0
species: 207243

252250
type: SpeciesReference
stoichiometry: 1.0
species: 207395

207610
type: Reaction
product: 245661
product: 245648
reactant: 245636
reactant: 245624
notes: GENE_ASSOCIATION: ( BCI_0544_thyA ) PROTEIN_ASSOCIATION: ( thymidylate synthase ) PROTEIN_CLASS: 2.1.1.45 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: METHYLENE__45__THF COFACTOR: DIHYDROFOLATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Thymidylate synthase

245661
type: SpeciesReference
stoichiometry: 1.0
species: 207407

245648
type: SpeciesReference
stoichiometry: 1.0
species: 207437

245636
type: SpeciesReference
stoichiometry: 1.0
species: 207389

245624
type: SpeciesReference
stoichiometry: 1.0
species: 207392

207641
type: Reaction
product: 246974
product: 246962
reactant: 246950
notes: GENE_ASSOCIATION: ( BCI_0402_hisB ) PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase/histidinol phosphatase//HISTIDPHOS-RXN//IMIDPHOSDEHYD-RXN ) PROTEIN_CLASS: 4.2.1.19 SUBSYSTEM: histidine biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Imidazoleglycerol-phosphate dehydratase

246974
type: SpeciesReference
stoichiometry: 1.0
species: 207542

246962
type: SpeciesReference
stoichiometry: 1.0
species: 207265

246950
type: SpeciesReference
stoichiometry: 1.0
species: 207453

207660
type: Reaction
reactant: 247824
reactant: 247849
name: NA
reactant: 247836
product: 247861
fast: false
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate polyglutamylation I SIDE: GLT SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
product: 247885
product: 247873
reversible: false

247824
type: SpeciesReference
stoichiometry: 1.0
species: 207273

247849
type: SpeciesReference
stoichiometry: 1.0
species: 207238

247836
type: SpeciesReference
stoichiometry: 1.0
species: 207375

247861
type: SpeciesReference
stoichiometry: 1.0
species: 207375

247885
type: SpeciesReference
stoichiometry: 1.0
species: 207243

247873
type: SpeciesReference
stoichiometry: 1.0
species: 207242

207748
type: Reaction
product: 251257
product: 251245
reactant: 251233
reactant: 251221
notes: GENE_ASSOCIATION: ( BCI_0258_pyrB ) or ( BCI_0259_pyrI ) PROTEIN_ASSOCIATION: ( aspartate carbamoyltransferase ) or ( aspartate carbamoyltransferase regulatory subunit//ASPCARBTRANS-RXN ) PROTEIN_CLASS: 2.1.3.2 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aspartate carbamoyltransferase

251257
type: SpeciesReference
stoichiometry: 1.0
species: 207435

251245
type: SpeciesReference
stoichiometry: 1.0
species: 207242

251233
type: SpeciesReference
stoichiometry: 1.0
species: 207383

251221
type: SpeciesReference
stoichiometry: 1.0
species: 207434

207798
type: Reaction
product: 253348
product: 253336
reactant: 253324
reactant: 253312
notes: GENE_ASSOCIATION: ( BCI_0075_tktA ) PROTEIN_ASSOCIATION: ( transketolase//1TRANSKETO-RXN ) PROTEIN_CLASS: 2.2.1.1 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (partial) SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Transketolase

253348
type: SpeciesReference
stoichiometry: 1.0
species: 207343

253336
type: SpeciesReference
stoichiometry: 1.0
species: 207249

253324
type: SpeciesReference
stoichiometry: 1.0
species: 207342

253312
type: SpeciesReference
stoichiometry: 1.0
species: 207340

207635
type: Reaction
product: 246725
product: 246713
reactant: 246700
reactant: 246688
notes: GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

246725
type: SpeciesReference
stoichiometry: 1.0
species: 207243

246713
type: SpeciesReference
stoichiometry: 1.0
species: 207399

246700
type: SpeciesReference
stoichiometry: 1.0
species: 207517

246688
type: SpeciesReference
stoichiometry: 1.0
species: 207238

207591
type: Reaction
fast: false
reversible: false
reactant: 244803
name: NA
product: 244827
reactant: 244815
notes: GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: tetrahydrofolate biosynthesis II SIDE: ATP SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 244790
product: 244839
product: 244851

244803
type: SpeciesReference
stoichiometry: 1.0
species: 207273

244827
type: SpeciesReference
stoichiometry: 1.0
species: 207243

244815
type: SpeciesReference
stoichiometry: 1.0
species: 207258

244790
type: SpeciesReference
stoichiometry: 1.0
species: 207238

244839
type: SpeciesReference
stoichiometry: 1.0
species: 207242

244851
type: SpeciesReference
stoichiometry: 1.0
species: 207558

207815
type: Reaction
product: 254108
product: 254096
reactant: 254084
reactant: 254072
notes: GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

254108
type: SpeciesReference
stoichiometry: 1.0
species: 207568

254096
type: SpeciesReference
stoichiometry: 1.0
species: 207280

254084
type: SpeciesReference
stoichiometry: 1.0
species: 207304

254072
type: SpeciesReference
stoichiometry: 1.0
species: 207294

207585
type: Reaction
product: 244597
product: 244585
reactant: 244573
notes: GENE_ASSOCIATION: ( BCI_0050_aroQ ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase ) PROTEIN_CLASS: 4.2.1.10 SUBSYSTEM: chorismate biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-dehydroquinate dehydratase

244597
type: SpeciesReference
stoichiometry: 1.0
species: 207265

244585
type: SpeciesReference
stoichiometry: 1.0
species: 207523

244573
type: SpeciesReference
stoichiometry: 1.0
species: 207552

207823
type: Reaction
reactant: 254337
product: 254385
reversible: false
reactant: 254349
name: Cystathionine &beta;-lyase
fast: false
notes: GENE_ASSOCIATION: ( BCI_0540_metC ) PROTEIN_ASSOCIATION: ( cystathionine beta-lyase//CYSTATHIONINE-BETA-LYASE-RXN ) PROTEIN_CLASS: 4.4.1.8 SUBSYSTEM: methionine biosynthesis I SIDE: WATER SIDE: PYRUVATE SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
product: 254373
product: 254361

254337
type: SpeciesReference
stoichiometry: 1.0
species: 207265

254385
type: SpeciesReference
stoichiometry: 1.0
species: 207293

254349
type: SpeciesReference
stoichiometry: 1.0
species: 207290

254373
type: SpeciesReference
stoichiometry: 1.0
species: 207259

254361
type: SpeciesReference
stoichiometry: 1.0
species: 207292

207716
type: Reaction
product: 250004
product: 249992
reactant: 249980
notes: GENE_ASSOCIATION: ( BCI_0219 ) PROTEIN_ASSOCIATION: ( 6-pyruvoyl-tetrahydropterin synthase ) PROTEIN_CLASS: 4.2.3.12 SUBSYSTEM: tetrahydrobioprein biosynthesis I SIDE: P3I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 6-pyruvoyltetrahydropterin synthase

250004
type: SpeciesReference
stoichiometry: 1.0
species: 207334

249992
type: SpeciesReference
stoichiometry: 1.0
species: 207473

249980
type: SpeciesReference
stoichiometry: 1.0
species: 207408

207795
type: Reaction
product: 253251
product: 253239
reactant: 253226
notes: GENE_ASSOCIATION: ( BCI_0221_eno ) PROTEIN_ASSOCIATION: ( Enolase (2-phosphoglycerate dehydratase) (2-phospho-D- glycerate hydro-lyase)//2PGADEHYDRAT-RXN ) PROTEIN_CLASS: 4.2.1.11 SUBSYSTEM: glycolysis I SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Phosphopyruvate hydratase

253251
type: SpeciesReference
stoichiometry: 1.0
species: 207349

253239
type: SpeciesReference
stoichiometry: 1.0
species: 207265

253226
type: SpeciesReference
stoichiometry: 1.0
species: 207348