GENE_ASSOCIATION: ( BCI_0110_gmk ) PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase ) PROTEIN_CLASS: 2.7.4.8 SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0183_dfp ) PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase ) PROTEIN_CLASS: 4.1.1.36 SUBSYSTEM: coenzyme A biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
Phosphopantothenoylcysteine decarboxylase
2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5'-phosphate
GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis II GENERIC: false TYPE: small HOLE: false
di-trans,poly-cis-heptaprenyl diphosphate
GENE_ASSOCIATION: ( BCI_0082_pdxH ) PROTEIN_ASSOCIATION: ( Pyridoxamine 5'-phosphate oxidase (PNP/PMP oxidase) (PNPOx)//PMPOXI-RXN//PNPOXI-RXN ) PROTEIN_CLASS: 1.4.3.5 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: pyridoxal 5'-phosphate salvage pathway SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 1.5.1.5 SUBSYSTEM: reductive acetyl coenzyme A pathway SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway) SUBSYSTEM: folate transformations SIDE: NADP SIDE: NADPH COFACTOR: NADP COFACTOR: NADPH GENERIC: false TYPE: small HOLE: false
Methylenetetrahydrofolate dehydrogenase (NADP+)
GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 2.1.1.107 SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation) SUBSYSTEM: siroheme biosynthesis SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion) SIDE: S__45__ADENOSYLMETHIONINE SIDE: ADENOSYL__45__HOMO__45__CYS COFACTOR: S__45__ADENOSYLMETHIONINE COFACTOR: ADENOSYL__45__HOMO__45__CYS GENERIC: false TYPE: small HOLE: false
Uroporphyrinogen-III C-methyltransferase
2-cis,6-trans,10-trans-geranylgeranyl diphosphate
GENE_ASSOCIATION: ( BCI_0068_cysK ) PROTEIN_ASSOCIATION: ( cysteine synthase A ) PROTEIN_CLASS: 2.5.1.47 SUBSYSTEM: superpathway of cysteine biosynthesis SUBSYSTEM: cysteine biosynthesis I SIDE: ACET GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0169_tpiA ) PROTEIN_ASSOCIATION: ( Triosephosphate isomerase (TIM) (Triose-phosphate isomerase)//TRIOSEPISOMERIZATION-RXN//Triose-phosphate isomerase ) PROTEIN_CLASS: 5.3.1.1 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0076_talB ) PROTEIN_ASSOCIATION: ( transaldolase A ) PROTEIN_CLASS: 2.2.1.2 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
Phosphogluconate dehydrogenase (decarboxylating)
GENE_ASSOCIATION: ( BCI_0397_gnd ) PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase, decarboxylating//6PGLUCONDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.44 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: NAD__45__P__45__OR__45__NOP SIDE: CARBON__45__DIOXIDE SIDE: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: purine nucleotides de novo biosynthesis I COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0008_ispG ) PROTEIN_ASSOCIATION: ( 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase ) PROTEIN_CLASS: 1.17.4.3 SUBSYSTEM: methylerythritol phosphate pathway SIDE: __124__Protein__45__Dithiols__124__ SIDE: __124__Protein__45__Disulfides__124__ SIDE: WATER GENERIC: true TYPE: small HOLE: false
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GENE_ASSOCIATION: ( BCI_0549_pabA ) or ( BCI_0453_pabB ) PROTEIN_ASSOCIATION: ( Para-aminobenzoate synthase, glutamine amidotransferase component ) or ( para-aminobenzoate synthase, component I ) PROTEIN_CLASS: 6.3.5.8 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0230_panB ) PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) (KPHMT)//3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN//3-methyl-2-oxobutanoate hydroxymethyltransferase ) PROTEIN_CLASS: 2.1.2.11 SUBSYSTEM: pantothenate biosynthesis I SIDE: WATER SIDE: METHYLENE__45__THF SIDE: THF COFACTOR: METHYLENE__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
3-methyl-2-oxobutanoate hydroxymethyltransferase
GENE_ASSOCIATION: ( BCI_0601_ribD ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibD//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN ) PROTEIN_CLASS: 3.5.4.26 SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0518_murC ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramate--alanine ligase//UDP-NACMUR-ALA-LIG-RXN ) PROTEIN_CLASS: 6.3.2.8 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0020_plsB ) PROTEIN_ASSOCIATION: ( glycerol-3-phosphate acyltransferase//GLYCEROL-3-P-ACYLTRANSFER-RXN ) PROTEIN_CLASS: 2.3.1.15 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SIDE: __124__Fatty__45__Acyl__45__CoA__124__ SIDE: CO__45__A COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__ COFACTOR: CO__45__A GENERIC: true TYPE: small HOLE: false
di-trans,poly-cis-octaprenyl diphosphate
GENE_ASSOCIATION: ( BCI_0561_folA ) PROTEIN_ASSOCIATION: ( dihydrofolate reductase ) PROTEIN_CLASS: 1.5.1.3 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0244_pgl ) PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase ) PROTEIN_CLASS: 3.1.1.31 SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0023_aroB ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate synthase ) PROTEIN_CLASS: 4.2.3.4 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
di-trans,poly-cis-hexaprenyl diphosphate
GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 4.99.1.4 SUBSYSTEM: siroheme biosynthesis SIDE: FE__43__2 SIDE: PROTON GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0402_hisB ) PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase/histidinol phosphatase//HISTIDPHOS-RXN//IMIDPHOSDEHYD-RXN ) PROTEIN_CLASS: 3.1.3.15 SUBSYSTEM: histidine biosynthesis I SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0587_psd ) PROTEIN_ASSOCIATION: ( Phosphatidylserine decarboxylase proenzyme [Contains: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]//PHOSPHASERDECARB-RXN//Phosphatidylserine decarboxylase ) PROTEIN_CLASS: 4.1.1.65 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0398_hisI ) PROTEIN_ASSOCIATION: ( phosphoribosyl-AMP cyclohydrolase//HISTCYCLOHYD-RXN ) PROTEIN_CLASS: 3.5.4.19 SUBSYSTEM: histidine biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate- D-alanyl-D-alanine
GENE_ASSOCIATION: ( BCI_0521_mraY ) PROTEIN_ASSOCIATION: ( phospho-N-acetylmuramoyl-pentapeptide- transferase//PHOSNACMURPENTATRANS-RXN ) PROTEIN_CLASS: 2.7.8.13 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: UNDECAPRENYL__45__P SIDE: UMP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0604_thiL ) PROTEIN_ASSOCIATION: ( thiamine monophosphate kinase//THI-P-KIN-RXN ) PROTEIN_CLASS: 2.7.4.16 SUBSYSTEM: thiamine biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0558_ispH ) PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN ) PROTEIN_CLASS: 1.17.1.2 SUBSYSTEM: methylerythritol phosphate pathway SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP SIDE: WATER COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0270_cyoE ) PROTEIN_ASSOCIATION: ( protoheme IX farnesyltransferase ) PROTEIN_CLASS: 2.5.1.- GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0062_hemD ) PROTEIN_ASSOCIATION: ( uroporphyrinogen-III synthase ) PROTEIN_CLASS: 4.2.1.75 SUBSYSTEM: tetrapyrrole biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0300_ribA ) PROTEIN_ASSOCIATION: ( GTP cyclohydrolase II ) PROTEIN_CLASS: 3.5.4.25 SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: FORMATE SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0025_pssA ) PROTEIN_ASSOCIATION: ( phosphatidylserine synthase//PHOSPHASERSYN-RXN ) PROTEIN_CLASS: 2.7.8.8 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis SIDE: SER SIDE: CMP GENERIC: true TYPE: small HOLE: false
CDP-diacylglycerol--serine O-phosphatidyltransferase
GENE_ASSOCIATION: ( BCI_0649_thiD ) PROTEIN_ASSOCIATION: ( phosphomethylpyrimidine kinase ) PROTEIN_CLASS: 2.7.4.7 SUBSYSTEM: thiamine biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0383_pta ) PROTEIN_ASSOCIATION: ( phosphate acetyltransferase//PHOSACETYLTRANS-RXN ) PROTEIN_CLASS: 2.3.1.8 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: sulfoacetaldehyde degradation SUBSYSTEM: acetate formation from acetyl-CoA I SUBSYSTEM: pyruvate fermentation to acetate II SUBSYSTEM: pyruvate fermentation to acetate IV SIDE: __124__Pi__124__ SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: folate polyglutamylation II SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
di-trans,poly-cis-pentaprenyl diphosphate
GENE_ASSOCIATION: ( BCI_0249_bioD ) PROTEIN_ASSOCIATION: ( Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS)//DETHIOBIOTIN-SYN-RXN//Dethiobiotin synthase ) PROTEIN_CLASS: 6.3.3.3 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: ATP SIDE: CARBON__45__DIOXIDE SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0279_pdxJ ) PROTEIN_ASSOCIATION: ( pyridoxal phosphate biosynthetic protein PdxJ ) PROTEIN_CLASS: 2.6.99.2 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0519_murG ) PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase ) PROTEIN_CLASS: 2.4.1.227 SUBSYSTEM: peptidoglycan biosynthesis I COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE COFACTOR: UDP GENERIC: false TYPE: small HOLE: false
Undecaprenyldiphospho-muramoylpentapeptide &beta;-N- acetylglucosaminyltransferase
GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0614_nadB ) PROTEIN_ASSOCIATION: ( L-aspartate oxidase ) PROTEIN_CLASS: 1.4.3.16 COFACTOR: L__45__ASPARTATE COFACTOR: OXALACETIC_ACID GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA SUBSYSTEM: formylTHF biosynthesis II SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0252_serC ) PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase//PSERTRANSAM-RXN//PSERTRANSAMPYR-RXN ) PROTEIN_CLASS: 2.6.1.52 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0549_pabA ) or ( BCI_0432_pabC ) or ( BCI_0453_pabB ) PROTEIN_ASSOCIATION: ( Para-aminobenzoate synthase, glutamine amidotransferase component ) or ( 4-amino-4-deoxychorismate lyase ) or ( para-aminobenzoate synthase, component I ) PROTEIN_CLASS: NA GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0036_purD ) PROTEIN_ASSOCIATION: ( phosphoribosylamine--glycine ligase ) PROTEIN_CLASS: 6.3.4.13 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: GLY SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0363_pdxB ) PROTEIN_ASSOCIATION: ( Erythronate-4-phosphate dehydrogenase//ERYTHRON4PDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.290 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0240_pgsA ) PROTEIN_ASSOCIATION: ( CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase ) PROTEIN_CLASS: 2.7.8.5 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: GLYCEROL__45__3P SIDE: CMP GENERIC: true TYPE: small HOLE: false
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis I SIDE: S__45__ADENOSYLMETHIONINE SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__ SIDE: CPD__45__249 SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__ SIDE: MET SIDE: CH33ADO GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0645_pgk ) PROTEIN_ASSOCIATION: ( phosphoglycerate kinase ) PROTEIN_CLASS: 2.7.2.3 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0251_gpmA ) PROTEIN_ASSOCIATION: ( phosphoglycerate mutase ) PROTEIN_CLASS: 5.4.2.1 SUBSYSTEM: glycolysis I SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0614_nadB ) PROTEIN_ASSOCIATION: ( L-aspartate oxidase ) PROTEIN_CLASS: 1.4.3.- SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0359_coaA ) PROTEIN_ASSOCIATION: ( pantothenate kinase ) PROTEIN_CLASS: 2.7.1.33 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0253_aroA ) PROTEIN_ASSOCIATION: ( 3-phosphoshikimate 1-carboxyvinyltransferase ) PROTEIN_CLASS: 2.5.1.19 SUBSYSTEM: chorismate biosynthesis SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
3-phosphoshikimate 1-carboxyvinyltransferase
GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) PROTEIN_CLASS: 1.17.4.1 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ SIDE: WATER COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
GENE_ASSOCIATION: ( BCI_0246_bioB ) PROTEIN_ASSOCIATION: ( biotin synthase ) PROTEIN_CLASS: 2.8.1.6 SUBSYSTEM: biotin biosynthesis II SIDE: CPD__45__249 SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__ SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__ GENERIC: true TYPE: small HOLE: false
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: ADP COFACTOR: UDP COFACTOR: ATP COFACTOR: ADP COFACTOR: UTP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0602_ribH ) PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase ) PROTEIN_CLASS: NA SUBSYSTEM: flavin biosynthesis SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
di-trans,poly-cis-decaprenyl diphosphate
GENE_ASSOCIATION: ( BCI_0288_nadE ) PROTEIN_ASSOCIATION: ( NAD synthetase//NAD-SYNTH-NH3-RXN ) PROTEIN_CLASS: 6.3.1.5 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: AMMONIA SIDE: ATP SIDE: PPI SIDE: AMP COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0017_metE ) PROTEIN_ASSOCIATION: ( 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase//HOMOCYSMET-RXN ) PROTEIN_CLASS: 2.1.1.14 SUBSYSTEM: methionine biosynthesis I SUBSYSTEM: S-adenosyl-L-methionine cycle SIDE: CPD__45__1302 SIDE: CPD__45__1301 GENERIC: false TYPE: small HOLE: false
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase
di-trans,poly-cis-undecaprenyl diphosphate
GENE_ASSOCIATION: ( BCI_0400_hisA ) PROTEIN_ASSOCIATION: ( 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)//PRIBFAICARPISOM-RXN ) PROTEIN_CLASS: 5.3.1.16 SUBSYSTEM: histidine biosynthesis I GENERIC: false TYPE: small HOLE: false
N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4- imidazole carboxamide isomerase
GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 3.5.4.9 SUBSYSTEM: tetrahydrofolate biosynthesis II SIDE: WATER GENERIC: true TYPE: small HOLE: false
(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
GENE_ASSOCIATION: ( BCI_0637_folP ) PROTEIN_ASSOCIATION: ( dihydropteroate synthase ) PROTEIN_CLASS: 2.5.1.15 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: purine nucleotides de novo biosynthesis I COFACTOR: ATP COFACTOR: GDP COFACTOR: ADP COFACTOR: GTP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0275_dxs ) PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose-5-phosphate synthase (1-deoxyxylulose- 5-phosphate synthase) (DXP synthase) (DXPS)//DXS-RXN//1-deoxy-D-xylulose-5-phosphate synthase ) PROTEIN_CLASS: 2.2.1.7 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SUBSYSTEM: methylerythritol phosphate pathway SUBSYSTEM: thiamine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0234_nadD ) PROTEIN_ASSOCIATION: ( Probable nicotinate-nucleotide adenylyltransferase (Deamido-NAD(+) pyrophosphorylase) (Deamido-NAD(+) diphosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase)//NICON ) PROTEIN_CLASS: 2.7.7.18 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
Nicotinate-nucleotide adenylyltransferase
GENE_ASSOCIATION: ( BCI_0482_gshB ) PROTEIN_ASSOCIATION: ( glutathione synthetase//GLUTATHIONE-SYN-RXN ) PROTEIN_CLASS: 6.3.2.3 SUBSYSTEM: glutathione biosynthesis SIDE: ATP SIDE: GLY SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0120_purE ) or ( BCI_0119_purK ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase, catalytic subunit ) or ( phosphoribosylaminoimidazole carboxylase ATPase subunit ) PROTEIN_CLASS: 4.1.1.21 SUBSYSTEM: purine nucleotides de novo biosynthesis II SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
Phosphoribosylaminoimidazole carboxylase
GENE_ASSOCIATION: ( BCI_0394_folE ) PROTEIN_ASSOCIATION: ( GTP cyclohydrolase I ) PROTEIN_CLASS: 3.5.4.16 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: tetrahydrobioprein biosynthesis I SIDE: WATER SIDE: FORMATE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0624_plsC ) PROTEIN_ASSOCIATION: ( 1-acyl-sn-glycerol-3-phosphate acyltransferase//1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN ) PROTEIN_CLASS: 2.3.1.51 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SIDE: __124__Fatty__45__Acyl__45__CoA__124__ SIDE: CO__45__A COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__ COFACTOR: CO__45__A GENERIC: true TYPE: small HOLE: false
2-dehydro-3-deoxyphosphoheptonate aldolase
GENE_ASSOCIATION: ( BCI_0191_aroH ) PROTEIN_ASSOCIATION: ( phospho-2-dehydro-3-heoxyheptonate aldolase ) PROTEIN_CLASS: 2.5.1.54 SUBSYSTEM: chorismate biosynthesis SIDE: WATER SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: gapA PROTEIN_ASSOCIATION: NA SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage PROTEIN_CLASS: 1.2.1.72 COFACTOR: NAD COFACTOR: NADH SIDE: PROTON SIDE: WATER SIDE: NAD SIDE: NADH GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0247_bioF ) PROTEIN_ASSOCIATION: ( 8-amino-7-oxononanoate synthase ) PROTEIN_CLASS: 2.3.1.47 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: CO__45__A SIDE: CARBON__45__DIOXIDE COFACTOR: CPD__45__558 COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0650_guaA ) PROTEIN_ASSOCIATION: ( bifunctional GMP synthase/glutamine amidotransferase protein//GMP-SYN-GLUT-RXN ) PROTEIN_CLASS: 6.3.5.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER SIDE: GLN SIDE: GLT SIDE: PPI COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
4-methyl-5-(&beta;-hydroxyethyl)thiazole phosphate
GENE_ASSOCIATION: ( BCI_0418_aroE ) PROTEIN_ASSOCIATION: ( dehydroshikimate reductase//SHIKIMATE-5-DEHYDROGENASE-RXN ) PROTEIN_CLASS: 1.1.1.25 SUBSYSTEM: chorismate biosynthesis SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0620_folB ) PROTEIN_ASSOCIATION: ( dihydroneopterin aldolase ) PROTEIN_CLASS: 4.1.2.25 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: GLYCOLALDEHYDE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0071_purC ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole-succinocarboxamide synthase//SAICARSYN-RXN ) PROTEIN_CLASS: 6.3.2.6 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
Phosphoribosylaminoimidazole-succinocarboxamide synthetase
GENE_ASSOCIATION: ( BCI_0441_pyrC ) PROTEIN_ASSOCIATION: ( dihydroorotase ) PROTEIN_CLASS: 3.5.2.3 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0012_pgi ) PROTEIN_ASSOCIATION: ( Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)//PGLUCISOM-RXN//Glucose-6-phosphate isomerase ) PROTEIN_CLASS: 5.3.1.9 SUBSYSTEM: glycolysis I SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0504_murB ) PROTEIN_ASSOCIATION: ( UDP-N-acetylenolpyruvoylglucosamine reductase//UDPNACETYLMURAMATEDEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.158 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0118_adk ) PROTEIN_ASSOCIATION: ( adenylate kinase ) PROTEIN_CLASS: 2.7.4.3 SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0162_metF ) PROTEIN_ASSOCIATION: ( 5,10-methylenetetrahydrofolate reductase ) PROTEIN_CLASS: 1.5.1.20 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate transformations SIDE: NADH__45__P__45__OR__45__NOP SIDE: PROTON SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
Methylenetetrahydrofolate reductase (NADPH)
GENE_ASSOCIATION: ( BCI_0621_uppP ) PROTEIN_ASSOCIATION: ( Undecaprenyl-diphosphatase (Undecaprenyl pyrophosphate phosphatase) (Bacitracin resistance protein)//Undecaprenyl-diphosphatase ) PROTEIN_CLASS: 3.6.1.27 GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0119_purK ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase ATPase subunit ) PROTEIN_CLASS: 6.3.4.18 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: HCO3 SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0229_folK ) PROTEIN_ASSOCIATION: ( 7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokina se//H2PTERIDINEPYROPHOSPHOKIN-RXN ) PROTEIN_CLASS: 2.7.6.3 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: ATP SIDE: AMP COFACTOR: ATP COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GENE_ASSOCIATION: ( BCI_0605_pgpA ) PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphatase ) PROTEIN_CLASS: 3.1.3.27 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: WATER SIDE: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0651_guaB ) PROTEIN_ASSOCIATION: ( inosine-5'-monophosphate dehydrogenase//IMP-DEHYDROG-RXN ) PROTEIN_CLASS: 1.1.1.205 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: NAD SIDE: WATER SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0398_hisI ) PROTEIN_ASSOCIATION: ( phosphoribosyl-AMP cyclohydrolase//HISTCYCLOHYD-RXN ) PROTEIN_CLASS: 3.6.1.31 SUBSYSTEM: histidine biosynthesis I SIDE: WATER SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0405_hisG ) PROTEIN_ASSOCIATION: ( ATP phosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.17 SUBSYSTEM: histidine biosynthesis I SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0041_thiC ) PROTEIN_ASSOCIATION: ( thiamine biosynthesis protein ThiC ) PROTEIN_CLASS: NA SUBSYSTEM: thiamine biosynthesis GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0222_pyrG ) PROTEIN_ASSOCIATION: ( CTP synthase (UTP--ammonia ligase) (CTP synthetase)//CTPSYN-RXN//CTP synthase ) PROTEIN_CLASS: 6.3.4.2 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: WATER SIDE: GLN SIDE: ADP SIDE: GLT SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0139_glmU ) PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P- ) PROTEIN_CLASS: 2.7.7.23 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: UTP SIDE: PPI GENERIC: false TYPE: small HOLE: false
UDP-N-acetylglucosamine pyrophosphorylase
GENE_ASSOCIATION: ( BCI_0611_nadK ) PROTEIN_ASSOCIATION: ( ATP-dependent NAD Kinase ) PROTEIN_CLASS: 2.7.1.23 SUBSYSTEM: NAD phosphorylation and dephosphorylation SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 SUBSYSTEM: histidine biosynthesis I SIDE: NAD SIDE: WATER SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
GENE_ASSOCIATION: ( BCI_0292_ispE ) PROTEIN_ASSOCIATION: ( 4-diphosphocytidyl-2C-methyl-D-erythritol kinase//2.7.1.148-RXN ) PROTEIN_CLASS: 2.7.1.148 SUBSYSTEM: methylerythritol phosphate pathway SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
GENE_ASSOCIATION: ( BCI_0163_metB ) PROTEIN_ASSOCIATION: ( O-succinylhomoserine (thiol)-lyase//METBALT-RXN//O-SUCCHOMOSERLYASE-RXN ) PROTEIN_CLASS: 2.5.1.48 GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0272_panE ) PROTEIN_ASSOCIATION: ( 2-dehydropantoate 2-reductase ) PROTEIN_CLASS: 1.1.1.169 SUBSYSTEM: pantothenate biosynthesis I SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0254_cmk ) PROTEIN_ASSOCIATION: ( cytidylate kinase ) PROTEIN_CLASS: 2.7.4.14 SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0153_murI ) PROTEIN_ASSOCIATION: ( glutamate racemase ) PROTEIN_CLASS: 5.1.1.3 SUBSYSTEM: peptidoglycan biosynthesis I GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0647_rpiA ) PROTEIN_ASSOCIATION: ( ribose-5-phosphate isomerase A//RIB5PISOM-RXN ) PROTEIN_CLASS: 5.3.1.6 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0125_dapF ) PROTEIN_ASSOCIATION: ( diaminopimelate epimerase ) PROTEIN_CLASS: 5.1.1.7 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: aspartate superpathway GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0382_ackA ) PROTEIN_ASSOCIATION: ( acetate kinase//ACETATEKIN-RXN ) PROTEIN_CLASS: 2.7.2.1 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: acetate formation from acetyl-CoA I SUBSYSTEM: pyruvate fermentation to acetate II SUBSYSTEM: pyruvate fermentation to acetate IV SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0122_folD ) PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofo ) PROTEIN_CLASS: 3.5.4.9 SUBSYSTEM: reductive acetyl coenzyme A pathway SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway) SUBSYSTEM: folate transformations SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0510_lpdA ) or ( BCI_0512_aceE ) or ( BCI_0511_aceF ) PROTEIN_ASSOCIATION: ( pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase ) or ( pyruvate dehydrogenase subunit E1//RXN0-1134 ) or ( pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase ) PROTEIN_CLASS: 1.2.1.- SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: pyruvate fermentation to acetate II SIDE: CO__45__A SIDE: NAD SIDE: NADH COFACTOR: CO__45__A COFACTOR: NAD COFACTOR: ACETYL__45__COA COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0045_thiG ) or ( BCI_0046_thiH ) PROTEIN_ASSOCIATION: ( thiazole synthase ) or ( thiH protein ) PROTEIN_CLASS: NA SUBSYSTEM: thiamine biosynthesis SIDE: _4__45__HYDROXY__45__BENZYL__45__ALCOHOL SIDE: __124__ThiF__45__Proteins__124__ SIDE: CARBON__45__DIOXIDE GENERIC: true TYPE: macro HOLE: false
GENE_ASSOCIATION: ( BCI_0420_fumC ) PROTEIN_ASSOCIATION: ( fumarate hydratase ) PROTEIN_CLASS: 4.2.1.2 SUBSYSTEM: mixed acid fermentation SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: TCA cycle variation II SUBSYSTEM: TCA cycle SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: folate polyglutamylation I SIDE: ATP SIDE: GLT SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0650_guaA ) PROTEIN_ASSOCIATION: ( bifunctional GMP synthase/glutamine amidotransferase protein//GMP-SYN-GLUT-RXN ) PROTEIN_CLASS: 6.3.4.1 SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: AMMONIA SIDE: PPI COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0210_ispF ) PROTEIN_ASSOCIATION: ( 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase//RXN0-302 ) PROTEIN_CLASS: 4.6.1.12 SUBSYSTEM: methylerythritol phosphate pathway SIDE: CMP GENERIC: false TYPE: small HOLE: false
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
GENE_ASSOCIATION: ( BCI_0423_purB ) PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN ) PROTEIN_CLASS: 4.3.2.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: FUM GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0305_cls ) PROTEIN_ASSOCIATION: ( cardiolipin synthetase ) PROTEIN_CLASS: 2.7.8.- SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: cardiolipin biosynthesis I SIDE: GLYCEROL GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0182_dut ) PROTEIN_ASSOCIATION: ( deoxyuridine 5''-triphosphate nucleotidohydrolase//DUTP-PYROP-RXN ) PROTEIN_CLASS: 3.6.1.23 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: WATER SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0404_hisD ) PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN ) PROTEIN_CLASS: 1.1.1.23 SUBSYSTEM: histidine biosynthesis I SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0245_bioA ) PROTEIN_ASSOCIATION: ( adenosylmethionine--8-amino-7-oxononanoate transaminase ) PROTEIN_CLASS: 2.6.1.62 SUBSYSTEM: biotin biosynthesis II SUBSYSTEM: biotin biosynthesis I SIDE: S__45__ADENOSYLMETHIONINE SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE GENERIC: false TYPE: small HOLE: false
Adenosylmethionine--8-amino-7-oxononanoate aminotransferase
GENE_ASSOCIATION: ( BCI_0293_prsA ) PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase//PRPPSYN-RXN ) PROTEIN_CLASS: 2.7.6.1 SUBSYSTEM: PRPP biosynthesis I SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SIDE: ATP COFACTOR: ATP COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0176_coaD ) PROTEIN_ASSOCIATION: ( pantetheine-phosphate adenylyltransferase ) PROTEIN_CLASS: 2.7.7.3 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
Pantetheine-phosphate adenylyltransferase
GENE_ASSOCIATION: ( BCI_0513_nadC ) PROTEIN_ASSOCIATION: ( nicotinate-nucleotide pyrophosphorylase//QUINOPRIBOTRANS-RXN ) PROTEIN_CLASS: 2.4.2.19 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: CARBON__45__DIOXIDE SIDE: PPI SIDE: PRPP GENERIC: false TYPE: small HOLE: false
Nicotinate-nucleotide pyrophosphorylase (carboxylating)
GENE_ASSOCIATION: ( BCI_0555_ribF ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibF ) PROTEIN_CLASS: 2.7.7.2 SUBSYSTEM: flavin biosynthesis SIDE: ATP SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0401_hisH ) or ( BCI_0399_hisF ) PROTEIN_ASSOCIATION: ( imidazole glycerol phosphate synthase, glutamine amidotransferase subunit ) or ( imidazole glycerol phosphate synthase subunit HisF ) PROTEIN_CLASS: 2.4.2.- SUBSYSTEM: histidine biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
aminoimidazole carboxamide ribonucleotide
GENE_ASSOCIATION: ( BCI_0514_coaE ) PROTEIN_ASSOCIATION: ( dephospho-CoA kinase ) PROTEIN_CLASS: 2.7.1.24 SUBSYSTEM: coenzyme A biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0403_hisC ) PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN ) PROTEIN_CLASS: 2.6.1.9 SUBSYSTEM: histidine biosynthesis I SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0075_tktA ) PROTEIN_ASSOCIATION: ( transketolase//1TRANSKETO-RXN ) PROTEIN_CLASS: 2.2.1.1 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (partial) SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0395_dcd ) PROTEIN_ASSOCIATION: ( 2-deoxycytidine 5-triphosphate deaminase//DCTP-DEAM-RXN ) PROTEIN_CLASS: 3.5.4.13 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.12 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SUBSYSTEM: formylTHF biosynthesis II SIDE: ATP SIDE: GLT SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0523_murE ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN ) SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP PROTEIN_CLASS: 6.3.2.13 GENERIC: true TYPE: small HOLE: false
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase
GENE_ASSOCIATION: ( BCI_0443_gapA ) PROTEIN_ASSOCIATION: ( glyceraldehyde-3-phosphate dehydrogenase, type I ) PROTEIN_CLASS: 1.2.1.12 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: NAD SIDE: __124__Pi__124__ SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)
GENE_ASSOCIATION: ( BCI_0648 ) PROTEIN_ASSOCIATION: ( 5-formyltetrahydrofolate cyclo-ligase family protein//5-formyltetrahydrofolate cyclo-ligase ) PROTEIN_CLASS: 6.3.3.2 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate transformations SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0201_gshA ) PROTEIN_ASSOCIATION: ( glutamate--cysteine ligase ) PROTEIN_CLASS: 6.3.2.2 SUBSYSTEM: glutathione biosynthesis SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0007_ndk ) PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN ) PROTEIN_CLASS: 2.7.4.6 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: CDP COFACTOR: ADP COFACTOR: CTP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0024_aroK ) PROTEIN_ASSOCIATION: ( shikimate kinase I//SHIKIMATE-KINASE-RXN ) PROTEIN_CLASS: 2.7.1.71 SUBSYSTEM: chorismate biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0072_purM ) PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamidine cyclo-ligase ) PROTEIN_CLASS: 6.3.3.1 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
phosphoribosylformylglycinamidine cyclo-ligase
GENE_ASSOCIATION: ( BCI_0309_zwf ) PROTEIN_ASSOCIATION: ( glucose-6-phosphate 1-dehydrogenase ) PROTEIN_CLASS: 1.1.1.49 SUBSYSTEM: formaldehyde oxidation I SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (oxidative branch) SIDE: NADP SIDE: PROTON SIDE: NADPH COFACTOR: NADP COFACTOR: NADPH GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0646_fbaA ) PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase ) PROTEIN_CLASS: 4.1.2.13 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0623_ribB ) PROTEIN_ASSOCIATION: ( 3,4-dihydroxy-2-butanone 4-phosphate synthase ) PROTEIN_CLASS: NA SUBSYSTEM: flavin biosynthesis SIDE: FORMATE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0532_uppS ) PROTEIN_ASSOCIATION: ( undecaprenyl diphosphate synthase ) PROTEIN_CLASS: 2.5.1.31 SUBSYSTEM: undecaprenyl diphosphate biosynthesis SIDE: DELTA3__45__ISOPENTENYL__45__PP SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0061_hemC ) PROTEIN_ASSOCIATION: ( Porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)//OHMETHYLBILANESYN-RXN//Hydroxymethylbilane synthase ) PROTEIN_CLASS: 2.5.1.61 SUBSYSTEM: tetrapyrrole biosynthesis I SIDE: WATER SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: NA SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: PROTON SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0073_purN ) PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase ) PROTEIN_CLASS: 2.1.2.2 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SUBSYSTEM: tetrahydrofolate biosynthesis I COFACTOR: _10__45__FORMYL__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
Phosphoribosylglycinamide formyltransferase
GENE_ASSOCIATION: ( BCI_0028_murA ) PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 1-carboxyvinyltransferase ) PROTEIN_CLASS: 2.5.1.7 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
GENE_ASSOCIATION: ( BCI_0015_metK ) PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT)//S-ADENMETSYN-RXN//Methionine adenosyltransferase ) PROTEIN_CLASS: 2.5.1.6 SUBSYSTEM: S-adenosyl-L-methionine cycle SUBSYSTEM: S-adenosylmethionine biosynthesis SIDE: ATP SIDE: WATER SIDE: PPI SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0022_rpe ) PROTEIN_ASSOCIATION: ( ribulose-phosphate 3-epimerase ) PROTEIN_CLASS: 5.1.3.1 SUBSYSTEM: pentose phosphate pathway SUBSYSTEM: pentose phosphate pathway (partial) SUBSYSTEM: pentose phosphate pathway (non-oxidative branch) SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0183_dfp ) PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase ) PROTEIN_CLASS: 6.3.2.5 SUBSYSTEM: coenzyme A biosynthesis SIDE: CYS SIDE: CTP SIDE: PPI SIDE: CMP COFACTOR: CTP COFACTOR: PPI COFACTOR: CMP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate polyglutamylation I SIDE: ATP SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: 2.1.2.1 SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: glycine biosynthesis I SUBSYSTEM: superpathway of serine and glycine biosynthesis I SUBSYSTEM: folate polyglutamylation I SUBSYSTEM: folate transformations SIDE: WATER COFACTOR: THF COFACTOR: METHYLENE__45__THF GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0224_pfs ) PROTEIN_ASSOCIATION: ( MTA/SAH nucleosidase ) PROTEIN_CLASS: 3.2.2.9 GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0173_gpsA ) PROTEIN_ASSOCIATION: ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN ) PROTEIN_CLASS: 1.1.1.94 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SUBSYSTEM: CDP-diacylglycerol biosynthesis I SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
Glycerol-3-phosphate dehydrogenase (NAD(P)+)
GENE_ASSOCIATION: ( BCI_0533_cdsA ) PROTEIN_ASSOCIATION: ( phosphatidate cytidylyltransferase ) PROTEIN_CLASS: 2.7.7.41 SUBSYSTEM: phospholipid biosynthesis I SUBSYSTEM: CDP-diacylglycerol biosynthesis SUBSYSTEM: CDP-diacylglycerol biosynthesis I SIDE: CTP SIDE: PPI GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0004_glyA ) PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) PROTEIN_CLASS: NA GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0211_ispD ) PROTEIN_ASSOCIATION: ( 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ) PROTEIN_CLASS: 2.7.7.60 SUBSYSTEM: methylerythritol phosphate pathway SIDE: CTP SIDE: PPI GENERIC: false TYPE: small HOLE: false
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
GENE_ASSOCIATION: ( BCI_0602_ribH ) or ( BCI_0087_ribE ) PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase ) or ( riboflavin synthase subunit alpha ) PROTEIN_CLASS: 2.5.1.9 SUBSYSTEM: flavin biosynthesis GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0298_pyrF ) PROTEIN_ASSOCIATION: ( orotidine 5'-phosphate decarboxylase//OROTPDECARB-RXN ) PROTEIN_CLASS: 4.1.1.23 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
Orotidine-5'-phosphate decarboxylase
GENE_ASSOCIATION: ( BCI_0409_pyrD ) PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase 2//DIHYDROOROTOX-RXN ) PROTEIN_CLASS: 1.3.3.1 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: OXYGEN__45__MOLECULE SIDE: HYDROGEN__45__PEROXIDE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0102_nadA ) PROTEIN_ASSOCIATION: ( quinolinate synthetase ) PROTEIN_CLASS: NA SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0593_aspA ) PROTEIN_ASSOCIATION: ( aspartate ammonia-lyase ) PROTEIN_CLASS: 4.3.1.1 SUBSYSTEM: glutamate degradation II SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0035_purH ) PROTEIN_ASSOCIATION: ( bifunctional purine biosynthesis protein PurH ) PROTEIN_CLASS: 3.5.4.10 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0274_ispA ) PROTEIN_ASSOCIATION: ( geranyltranstransferase//FPPSYN-RXN ) PROTEIN_CLASS: 2.5.1.10 SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0601_ribD ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibD//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN ) PROTEIN_CLASS: 1.1.1.193 SUBSYSTEM: flavin biosynthesis SIDE: NADPH SIDE: PROTON SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0254_cmk ) or ( BCI_0529_pyrH ) PROTEIN_ASSOCIATION: ( cytidylate kinase ) or ( uridylate kinase ) PROTEIN_CLASS: 2.7.4.14 SUBSYSTEM: pyrimidine ribonucleotides interconversion SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
This is metabolic network reconstruction of Baumannia cicadellinicola described in the article Graph-Based Analysis of the Metabolic Exchanges between Two Co-Resident Intracellular Symbionts, Baumannia cicadellinicola and Sulcia muelleri, with Their Insect Host, Homalodisca coagulata. Cottret L, Milreu PV, Acuña V, Marchetti-Spaccamela A, Stougie L, Charles H, Sagot MF. PLoS Comput Biol. 2010 Sep 2;6(9). pii: e1000904. PMID: 20838465 , DOI: 10.1371/journal.pcbi.1000904 Abstract: Endosymbiotic bacteria from different species can live inside cells of the same eukaryotic organism. Metabolic exchanges occur between host and bacteria but also between different endocytobionts. Since a complete genome annotation is available for both, we built the metabolic network of two endosymbiotic bacteria, Sulcia muelleri and Baumannia cicadellinicola, that live inside specific cells of the sharpshooter Homalodisca coagulata and studied the metabolic exchanges involving transfers of carbon atoms between the three. We automatically determined the set of metabolites potentially exogenously acquired (seeds) for both metabolic networks. We show that the number of seeds needed by both bacteria in the carbon metabolism is extremely reduced. Moreover, only three seeds are common to both metabolic networks, indicating that the complementarity of the two metabolisms is not only manifested in the metabolic capabilities of each bacterium, but also by their different use of the same environment. Furthermore, our results show that the carbon metabolism of S. muelleri may be completely independent of the metabolic network of B. cicadellinicola. On the contrary, the carbon metabolism of the latter appears dependent on the metabolism of S. muelleri, at least for two essential amino acids, threonine and lysine. Next, in order to define which subsets of seeds (precursor sets) are sufficient to produce the metabolites involved in a symbiotic function, we used a graph-based method, PITUFO, that we recently developed. Our results highly refine our knowledge about the complementarity between the metabolisms of the two bacteria and their host. We thus indicate seeds that appear obligatory in the synthesis of metabolites are involved in the symbiotic function. Our results suggest both B. cicadellinicola and S. muelleri may be completely independent of the metabolites provided by the co-resident endocytobiont to produce the carbon backbone of the metabolites provided to the symbiotic system (ie., thr and lys are only exploited by B. cicadellinicola to produce its proteins). This model was downloaded as a supplement to the article. This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
di-trans,poly-cis-nonaprenyl diphosphate
GENE_ASSOCIATION: ( BCI_0019_metA ) PROTEIN_ASSOCIATION: ( homoserine O-succinyltransferase ) PROTEIN_CLASS: 2.3.1.46 SUBSYSTEM: methionine biosynthesis I SIDE: SUC__45__COA SIDE: CO__45__A COFACTOR: SUC__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0163_metB ) PROTEIN_ASSOCIATION: ( O-succinylhomoserine (thiol)-lyase//METBALT-RXN//O-SUCCHOMOSERLYASE-RXN ) PROTEIN_CLASS: 2.5.1.48 SUBSYSTEM: methionine biosynthesis I SIDE: CYS SIDE: SUC GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0172_cysE ) PROTEIN_ASSOCIATION: ( serine acetyltransferase//SERINE-O-ACETTRAN-RXN ) PROTEIN_CLASS: 2.3.1.30 SUBSYSTEM: superpathway of cysteine biosynthesis SUBSYSTEM: cysteine biosynthesis I SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
phosphoribosylformylglycinamidine synthetase
GENE_ASSOCIATION: ( BCI_0002_purL ) PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamidine synthase ) PROTEIN_CLASS: 6.3.5.3 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: WATER SIDE: GLN SIDE: GLT SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0231_panC ) PROTEIN_ASSOCIATION: ( Pantothenate synthetase (PS) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase ) PROTEIN_CLASS: 6.3.2.1 SUBSYSTEM: pantothenate biosynthesis I SIDE: ATP SIDE: PPI SIDE: AMP COFACTOR: ATP COFACTOR: PPI COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0361_aroC ) PROTEIN_ASSOCIATION: ( Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase)//CHORISMATE-SYNTHASE-RXN//Chorismate synthase ) PROTEIN_CLASS: 4.2.3.5 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0310_pykA ) PROTEIN_ASSOCIATION: ( pyruvate kinase ) PROTEIN_CLASS: 2.7.1.40 SUBSYSTEM: glycolysis I SUBSYSTEM: mixed acid fermentation SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SIDE: ADP SIDE: ATP COFACTOR: ADP COFACTOR: ATP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0171_pfkA ) PROTEIN_ASSOCIATION: ( 6-phosphofructokinase//6PFRUCTPHOS-RXN ) PROTEIN_CLASS: 2.7.1.11 SUBSYSTEM: glycolysis I SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle) SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides PROTEIN_CLASS: 1.17.4.1 COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ SIDE: WATER SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
GENE_ASSOCIATION: ( BCI_0215_cysG ) PROTEIN_ASSOCIATION: ( siroheme synthase ) PROTEIN_CLASS: 1.3.1.76 SUBSYSTEM: siroheme biosynthesis SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0365_accD ) or ( BCI_0052_accC ) or ( BCI_0051_accB ) or ( BCI_0539_accA ) PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase, carboxyl transferase, beta subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) or ( acetyl-CoA carboxylase biotin carboxylase subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN ) or ( acetyl-CoA carboxylase, biotin carboxyl carrier protein ) or ( acetyl-CoA carboxylase, carboxyl transferase, alpha subunit//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) PROTEIN_CLASS: 6.4.1.2 SUBSYSTEM: fatty acid biosynthesis - initial steps I SUBSYSTEM: superpathway of fatty acid biosynthesis SIDE: ATP SIDE: HCO3 SIDE: PROTON SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0555_ribF ) PROTEIN_ASSOCIATION: ( riboflavin biosynthesis protein RibF ) PROTEIN_CLASS: 2.7.1.26 SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis SUBSYSTEM: flavin biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0531_dxr ) PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose 5-phosphate reductoisomerase//DXPREDISOM-RXN ) PROTEIN_CLASS: 1.1.1.267 SUBSYSTEM: methylerythritol phosphate pathway SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0073_purN ) PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase ) PROTEIN_CLASS: 2.1.2.- SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: FORMATE SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0288_nadE ) PROTEIN_ASSOCIATION: ( NAD synthetase//NAD-SYNTH-NH3-RXN ) PROTEIN_CLASS: 6.3.5.1 SUBSYSTEM: NAD biosynthesis I (from aspartate) SUBSYSTEM: aspartate superpathway SIDE: GLN SIDE: WATER SIDE: ATP SIDE: AMP SIDE: GLT SIDE: PPI COFACTOR: ATP COFACTOR: AMP COFACTOR: PPI GENERIC: false TYPE: small HOLE: false
NAD(+) synthetase (glutamine-hydrolysing)
GENE_ASSOCIATION: ( BCI_0368_purF ) PROTEIN_ASSOCIATION: ( amidophosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.14 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: GLN SIDE: WATER SIDE: PPI SIDE: GLT GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0559_carA ) or ( BCI_0560_carB ) PROTEIN_ASSOCIATION: ( carbamoyl-phosphate synthase, small subunit//CARBPSYN-RXN ) or ( carbamoyl-phosphate synthase, large subunit//CARBPSYN-RXN ) PROTEIN_CLASS: 6.3.5.5 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: WATER SIDE: ATP SIDE: GLN SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
carbamoyl-phosphate synthetase (glutamine-hydrolysing)
GENE_ASSOCIATION: ( BCI_0139_glmU ) PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P- ) PROTEIN_CLASS: 2.3.1.157 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
Glucosamine-1-phosphate N-acetyltransferase
SUBSYSTEM: geranyldiphosphate biosynthesis SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP) SUBSYSTEM: superpathway of cholesterol biosynthesis SUBSYSTEM: superpathway of ergosterol biosynthesis SUBSYSTEM: polyisoprenoid biosynthesis (E. coli) SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) PROTEIN_CLASS: 2.5.1.1 SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0385_nrdB ) or ( BCI_0386 ) PROTEIN_ASSOCIATION: ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleotide-diphosphate reductase subunit alpha ) PROTEIN_CLASS: 1.17.4.1 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides PROTEIN_CLASS: 1.17.4.1 COFACTOR: __124__Red__45__Thioredoxin__124__ COFACTOR: __124__Ox__45__Thioredoxin__124__ SIDE: WATER SIDE: __124__Red__45__Thioredoxin__124__ SIDE: __124__Ox__45__Thioredoxin__124__ GENERIC: true TYPE: macro HOLE: false
GENE_ASSOCIATION: ( BCI_0120_purE ) PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase, catalytic subunit ) PROTEIN_CLASS: NA SUBSYSTEM: purine nucleotides de novo biosynthesis I GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0035_purH ) PROTEIN_ASSOCIATION: ( bifunctional purine biosynthesis protein PurH ) PROTEIN_CLASS: 2.1.2.3 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: _10__45__FORMYL__45__THF SIDE: THF COFACTOR: _10__45__FORMYL__45__THF COFACTOR: THF GENERIC: false TYPE: small HOLE: false
Phosphoribosylaminoimidazolecarboxamide formyltransferase
GENE_ASSOCIATION: ( BCI_0431_tmk ) PROTEIN_ASSOCIATION: ( thymidylate kinase//DTMPKI-RXN ) PROTEIN_CLASS: 2.7.4.9 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides SIDE: ATP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0564_pdxA ) PROTEIN_ASSOCIATION: ( 4-hydroxythreonine-4-phosphate dehydrogenase ) PROTEIN_CLASS: 1.1.1.262 SUBSYSTEM: pyridoxal 5'-phosphate biosynthesis SUBSYSTEM: superpathway of pyridoxal 5'-phosphate biosynthesis and salvage SIDE: NAD SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
4-hydroxythreonine-4-phosphate dehydrogenase
GENE_ASSOCIATION: ( BCI_0001_mqo ) PROTEIN_ASSOCIATION: ( malate:quinone oxidoreductase//MALATE-DEHYDROGENASE-(ACCEPTOR)-RXN ) PROTEIN_CLASS: 1.1.99.16 SUBSYSTEM: TCA cycle variation II SIDE: VITAMIN_K_2 SIDE: REDUCED__45__MENAQUINONE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0388_ddlA ) PROTEIN_ASSOCIATION: ( D-ala D-ala ligase ) PROTEIN_CLASS: 6.3.2.4 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0636_glmM ) PROTEIN_ASSOCIATION: ( Phosphoglucosamine mutase//5.4.2.10-RXN//Phosphoglucosamine mutase ) PROTEIN_CLASS: 5.4.2.10 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0042_thiE ) PROTEIN_ASSOCIATION: ( thiamine-phosphate pyrophosphorylase//THI-P-SYN-RXN ) PROTEIN_CLASS: 2.5.1.3 SUBSYSTEM: thiamine biosynthesis SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0432_pabC ) PROTEIN_ASSOCIATION: ( 4-amino-4-deoxychorismate lyase ) PROTEIN_CLASS: 4.1.3.38 SUBSYSTEM: tetrahydrofolate biosynthesis II SUBSYSTEM: tetrahydrofolate biosynthesis I SIDE: PYRUVATE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0522_murF ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase//UDP-NACMURALGLDAPAALIG-RXN ) PROTEIN_CLASS: 6.3.2.10 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase
UDP-N-acetylmuramoylalanine--D-glutamate ligase
GENE_ASSOCIATION: ( BCI_0520_murD ) PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanine--D-glutamate ligase (UDP-N- acetylmuramoyl-L-alanyl-D-glutamate synthetase) (D-glutamic acid- adding enzyme)//UDP-NACMURALA-GLU-LIG-RXN ) PROTEIN_CLASS: 6.3.2.9 SUBSYSTEM: peptidoglycan biosynthesis I SIDE: ATP SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0577_purA ) PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase//ADENYLOSUCCINATE-SYNTHASE-RXN ) PROTEIN_CLASS: 6.3.4.4 SUBSYSTEM: purine nucleotides de novo biosynthesis II SUBSYSTEM: purine nucleotides de novo biosynthesis I SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ COFACTOR: GTP COFACTOR: GDP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0181_pyrE ) PROTEIN_ASSOCIATION: ( orotate phosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.10 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: PPI GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0138_glmS ) PROTEIN_ASSOCIATION: ( glucosamine--fructose-6-phosphate aminotransferase, isomerizing//L-GLN-FRUCT-6-P-AMINOTRANS-RXN ) PROTEIN_CLASS: 2.6.1.16 SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I SIDE: GLN SIDE: GLT GENERIC: false TYPE: small HOLE: false
Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)
GENE_ASSOCIATION: ( BCI_0013_pckA ) PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxykinase ) PROTEIN_CLASS: 4.1.1.49 SUBSYSTEM: gluconeogenesis SIDE: ATP SIDE: CARBON__45__DIOXIDE SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0544_thyA ) PROTEIN_ASSOCIATION: ( thymidylate synthase ) PROTEIN_CLASS: 2.1.1.45 SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides COFACTOR: METHYLENE__45__THF COFACTOR: DIHYDROFOLATE GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0402_hisB ) PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase/histidinol phosphatase//HISTIDPHOS-RXN//IMIDPHOSDEHYD-RXN ) PROTEIN_CLASS: 4.2.1.19 SUBSYSTEM: histidine biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: formylTHF biosynthesis II SUBSYSTEM: folate polyglutamylation I SIDE: GLT SIDE: ATP SIDE: __124__Pi__124__ SIDE: ADP COFACTOR: ATP COFACTOR: __124__Pi__124__ COFACTOR: ADP GENERIC: true TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0258_pyrB ) or ( BCI_0259_pyrI ) PROTEIN_ASSOCIATION: ( aspartate carbamoyltransferase ) or ( aspartate carbamoyltransferase regulatory subunit//ASPCARBTRANS-RXN ) PROTEIN_CLASS: 2.1.3.2 SUBSYSTEM: de novo biosynthesis of uridine-5'-monophosphate SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides SIDE: L__45__ASPARTATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0366_folC ) PROTEIN_ASSOCIATION: ( dihydrofolate:folylpolyglutamate synthetase//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 ) PROTEIN_CLASS: 6.3.2.17 SUBSYSTEM: tetrahydrofolate biosynthesis II SIDE: ATP SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0050_aroQ ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase ) PROTEIN_CLASS: 4.2.1.10 SUBSYSTEM: chorismate biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0540_metC ) PROTEIN_ASSOCIATION: ( cystathionine beta-lyase//CYSTATHIONINE-BETA-LYASE-RXN ) PROTEIN_CLASS: 4.4.1.8 SUBSYSTEM: methionine biosynthesis I SIDE: WATER SIDE: PYRUVATE SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0219 ) PROTEIN_ASSOCIATION: ( 6-pyruvoyl-tetrahydropterin synthase ) PROTEIN_CLASS: 4.2.3.12 SUBSYSTEM: tetrahydrobioprein biosynthesis I SIDE: P3I GENERIC: false TYPE: small HOLE: false
GENE_ASSOCIATION: ( BCI_0221_eno ) PROTEIN_ASSOCIATION: ( Enolase (2-phosphoglycerate dehydratase) (2-phospho-D- glycerate hydro-lyase)//2PGADEHYDRAT-RXN ) PROTEIN_CLASS: 4.2.1.11 SUBSYSTEM: glycolysis I SUBSYSTEM: respiration (anaerobic) SUBSYSTEM: formaldehyde assimilation I (serine pathway) SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass SUBSYSTEM: gluconeogenesis SIDE: WATER GENERIC: false TYPE: small HOLE: false