MODEL1011080000
type: SBMLModel
reaction: 269092
species: 269013
reaction: 269098
compartment: 268873
reaction: 269130
area units: area
reaction: 269173
reaction: 269126
reaction: 269198
reaction: 269225
species: 268937
species: 268890
reaction: 269267
species: 269032
species: 268897
species: 268960
species: 269090
species: 268926
species: 269039
species: 269057
species: 268984
reaction: 269170
reaction: 269184
species: 268886
reaction: 269167
reaction: 269213
species: 269028
is described by: http://identifiers.org/pubmed/20838465
reaction: 269264
species: 268956
species: 268973
substance units: substance
species: 268991
reaction: 269255
reaction: 269210
reaction: 269100
species: 269018
reaction: 269246
reaction: 269136
species: 269077
reaction: 269154
reaction: 269207
species: 269049
species: 269066
species: 268976
reaction: 269095
reaction: 269146
species: 269020
species: 268930
species: 269061
species: 268915
species: 268874
reaction: 269143
species: 268944
reaction: 269195
time units: time
species: 269081
species: 269006
reaction: 269258
reaction: 269148
reaction: 269120
species: 268877
species: 268895
species: 269070
species: 269037
species: 268907
reaction: 269102
species: 268964
reaction: 269201
species: 268982
species: 268884
species: 268948
reaction: 269138
species: 269079
volume units: volume
reaction: 269192
species: 269009
species: 268936
species: 268953

269092
type: Reaction
product: 186833
product: 186820
reactant: 186807
reactant: 186795
notes: GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: 3.5.1.18 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: aspartate superpathway PROTEIN_CLASS: 3.5.1.18 SIDE: SUC SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Succinyl-diaminopimelate desuccinylase

186833
type: SpeciesReference
stoichiometry: 1.0
species: 269068

269068
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: succinate

268873
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

186820
type: SpeciesReference
stoichiometry: 1.0
species: 268986

268986
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L,L-diaminopimelate

186807
type: SpeciesReference
stoichiometry: 1.0
species: 269035

269035
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-succinyl-L,L-2,6-diaminopimelate

186795
type: SpeciesReference
stoichiometry: 1.0
species: 268899

268899
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: H2O

269013
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetylglutamyl-phosphate

269098
type: Reaction
fast: false
reactant: 186919
notes: GENE_ASSOCIATION: ( SMGWSS_262_ilvC ) PROTEIN_ASSOCIATION: ( ketol-acid reductoisomerase ) PROTEIN_CLASS: 1.1.1.86 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: valine biosynthesis SIDE: PROTON SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
reactant: 186907
reversible: false
name: Ketol-acid reductoisomerase
reactant: 186894
product: 186943
product: 186931

186919
type: SpeciesReference
stoichiometry: 1.0
species: 269030

269030
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-acetolactate

186907
type: SpeciesReference
stoichiometry: 1.0
species: 268998

268998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NADPH

186894
type: SpeciesReference
stoichiometry: 1.0
species: 268944

268944
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: H+

186943
type: SpeciesReference
stoichiometry: 1.0
species: 268966

268966
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2,3-dihydroxy-isovalerate

186931
type: SpeciesReference
stoichiometry: 1.0
species: 269003

269003
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NADP+

269130
type: Reaction
notes: GENE_ASSOCIATION: ( SMGWSS_122 ) or ( SMGWSS_121_trpA ) PROTEIN_ASSOCIATION: ( putative tryptophan synthase, beta subunit (trpB)/anthranilate isomerase activity of trpC (trpF) ) or ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase ) PROTEIN_CLASS: 4.2.1.20 GENERIC: false TYPE: small HOLE: false
reversible: true
product: 187552
reactant: 187528
name: Tryptophan synthase
reactant: 187540
product: 187576
product: 187564
fast: false

187552
type: SpeciesReference
stoichiometry: 1.0
species: 268936

268936
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-tryptophan

187528
type: SpeciesReference
stoichiometry: 1.0
species: 268930

268930
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: indole-3-glycerol-phosphate

187540
type: SpeciesReference
stoichiometry: 1.0
species: 268934

268934
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-serine

187576
type: SpeciesReference
stoichiometry: 1.0
species: 268899

187564
type: SpeciesReference
stoichiometry: 1.0
species: 268882

268882
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: D-glyceraldehyde-3-phosphate

269173
type: Reaction
product: 188384
product: 188372
reactant: 188360
reactant: 188348
notes: GENE_ASSOCIATION: ( SMGWSS_210_aspC ) PROTEIN_ASSOCIATION: ( putative aspartate aminotransferase ) PROTEIN_CLASS: 2.6.1.1 SUBSYSTEM: aspartate degradation I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: threonine biosynthesis SUBSYSTEM: aspartate biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: _2__45__KETOGLUTARATE COFACTOR: _2__45__KETOGLUTARATE COFACTOR: L__45__ASPARTATE COFACTOR: OXALACETIC_ACID COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Aspartate aminotransferase

188384
type: SpeciesReference
stoichiometry: 1.0
species: 268911

268911
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-glutamate

188372
type: SpeciesReference
stoichiometry: 1.0
species: 269049

269049
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: oxaloacetate

188360
type: SpeciesReference
stoichiometry: 1.0
species: 269045

269045
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-aspartate

188348
type: SpeciesReference
stoichiometry: 1.0
species: 268907

268907
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-ketoglutarate

269126
type: Reaction
product: 187480
product: 187467
reactant: 187455
reactant: 187443
notes: GENE_ASSOCIATION: ( SMGWSS_139_thrC ) PROTEIN_ASSOCIATION: ( threonine synthase ) PROTEIN_CLASS: 4.2.3.1 SUBSYSTEM: threonine biosynthesis from homoserine SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: WATER SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Threonine synthase

187480
type: SpeciesReference
stoichiometry: 1.0
species: 268886

268886
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: phosphate

187467
type: SpeciesReference
stoichiometry: 1.0
species: 269061

269061
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-threonine

187455
type: SpeciesReference
stoichiometry: 1.0
species: 268899

187443
type: SpeciesReference
stoichiometry: 1.0
species: 269022

269022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: O-phospho-L-homoserine

269198
type: Reaction
notes: GENE_ASSOCIATION: ( SMGWSS_110_argC ) PROTEIN_ASSOCIATION: ( N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (N- acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase)//N-ACETYLGLUTPREDUCT-RXN//N-acetyl-gamma-glutamyl-phosphate reductase ) PROTEIN_CLASS: 1.2.1.38 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: NADPH SIDE: __124__Pi__124__ SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
product: 188842
product: 188830
reversible: false
reactant: 188805
product: 188854
reactant: 188818
name: N-acetyl-&gamma;-glutamyl-phosphate reductase
fast: false

188842
type: SpeciesReference
stoichiometry: 1.0
species: 269003

188830
type: SpeciesReference
stoichiometry: 1.0
species: 268886

188805
type: SpeciesReference
stoichiometry: 1.0
species: 268998

188854
type: SpeciesReference
stoichiometry: 1.0
species: 269015

269015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetyl-L-glutamate 5-semialdehyde

188818
type: SpeciesReference
stoichiometry: 1.0
species: 269013

269225
type: Reaction
product: 189264
product: 189252
reactant: 189240
reactant: 189228
notes: GENE_ASSOCIATION: ( SMGWSS_042_leuC ) or ( SMGWSS_041_leuD ) PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydratase large subunit ) or ( 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)//3-ISOPROPYLMALISOM-RXN//3-isopropylmalate dehydratase ) PROTEIN_CLASS: 4.2.1.33 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-isopropylmalate dehydratase

189264
type: SpeciesReference
stoichiometry: 1.0
species: 268978

268978
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: isopropylmaleate

189252
type: SpeciesReference
stoichiometry: 1.0
species: 268899

189240
type: SpeciesReference
stoichiometry: 1.0
species: 268976

268976
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-isopropylmalate

189228
type: SpeciesReference
stoichiometry: 1.0
species: 268899

268937
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: chorismate

268890
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NADH

269267
type: Reaction
product: 189915
product: 189903
reactant: 189891
reactant: 189879
notes: GENE_ASSOCIATION: ( SMGWSS_264_ilvB ) or ( SMGWSS_263_ilvN ) PROTEIN_ASSOCIATION: ( putative acetolactate synthase large subunit ) or ( putative acetolactate synthase small subunit ) PROTEIN_CLASS: 2.2.1.6 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: PYRUVATE SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetolactate synthase

189915
type: SpeciesReference
stoichiometry: 1.0
species: 268880

268880
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: CO2

189903
type: SpeciesReference
stoichiometry: 1.0
species: 268877

268877
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-aceto-2-hydroxy-butyrate

189891
type: SpeciesReference
stoichiometry: 1.0
species: 268875

268875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: pyruvate

189879
type: SpeciesReference
stoichiometry: 1.0
species: 268874

268874
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-oxobutanoate

269032
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-succinyl-2-amino-6-ketopimelate

268897
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: fumarate

268960
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-(5'-phosphoribosyl)-anthranilate

269090
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-phenylalanine

268926
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 5-enolpyruvyl-shikimate-3-phosphate

269039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: S-adenosyl-L-homocysteine

269057
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: citrulline

268984
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: demethylmenaquinone-8

269170
type: Reaction
product: 188336
product: 188323
reactant: 188311
reactant: 188299
notes: GENE_ASSOCIATION: ( SMGWSS_116 ) PROTEIN_ASSOCIATION: ( putative acetylornithine deacetylase (argE)/succinyl-diaminopimelate desuccinylase (dapE) ) PROTEIN_CLASS: 3.5.1.16 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SIDE: WATER SIDE: ACET GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetylornithine deacetylase

188336
type: SpeciesReference
stoichiometry: 1.0
species: 269055

269055
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-ornithine

188323
type: SpeciesReference
stoichiometry: 1.0
species: 269052

269052
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: acetate

188311
type: SpeciesReference
stoichiometry: 1.0
species: 269009

269009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetyl-L-ornithine

188299
type: SpeciesReference
stoichiometry: 1.0
species: 268899

269184
type: Reaction
product: 188564
product: 188552
reactant: 188540
notes: GENE_ASSOCIATION: ( SMGWSS_264_ilvB ) or ( SMGWSS_263_ilvN ) PROTEIN_ASSOCIATION: ( putative acetolactate synthase large subunit ) or ( putative acetolactate synthase small subunit ) PROTEIN_CLASS: 2.2.1.6 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: valine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetolactate synthase

188564
type: SpeciesReference
stoichiometry: 1.0
species: 269030

188552
type: SpeciesReference
stoichiometry: 1.0
species: 268880

188540
type: SpeciesReference
stoichiometry: 2.0
species: 268875

269167
type: Reaction
product: 188287
product: 188275
reactant: 188263
reactant: 188251
notes: GENE_ASSOCIATION: ( SMGWSS_116 ) PROTEIN_ASSOCIATION: ( putative acetylornithine deacetylase (argE)/succinyl-diaminopimelate desuccinylase (dapE) ) PROTEIN_CLASS: 3.5.1.16 SUBSYSTEM: arginine biosynthesis III SIDE: WATER SIDE: ACET GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

188287
type: SpeciesReference
stoichiometry: 1.0
species: 269052

188275
type: SpeciesReference
stoichiometry: 1.0
species: 269057

188263
type: SpeciesReference
stoichiometry: 1.0
species: 269011

269011
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetyl-L-citrulline

188251
type: SpeciesReference
stoichiometry: 1.0
species: 268899

269213
type: Reaction
product: 189083
fast: false
reactant: 189046
product: 189095
reactant: 189070
notes: GENE_ASSOCIATION: ( SMGWSS_043_leuA ) PROTEIN_ASSOCIATION: ( 2-isopropylmalate synthase ) PROTEIN_CLASS: 2.3.3.13 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: WATER SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
reversible: false
name: 2-isopropylmalate synthase
reactant: 189058

189083
type: SpeciesReference
stoichiometry: 1.0
species: 268915

268915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: coenzyme A

189046
type: SpeciesReference
stoichiometry: 1.0
species: 268899

189095
type: SpeciesReference
stoichiometry: 1.0
species: 268976

189070
type: SpeciesReference
stoichiometry: 1.0
species: 268969

268969
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-keto-isovalerate

189058
type: SpeciesReference
stoichiometry: 1.0
species: 268919

268919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: acetyl-CoA

269028
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-aspartate-semialdehyde

269264
type: Reaction
notes: GENE_ASSOCIATION: ( SMGWSS_257_gapA ) PROTEIN_ASSOCIATION: ( glyceraldehyde 3-phosphate dehydrogenase ) PROTEIN_CLASS: 1.2.1.12 SIDE: NAD SIDE: __124__Pi__124__ SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
reactant: 189831
reactant: 189843
fast: false
name: Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)
product: 189855
reactant: 189819
reversible: true
product: 189867

189831
type: SpeciesReference
stoichiometry: 1.0
species: 268884

268884
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NAD+

189843
type: SpeciesReference
stoichiometry: 1.0
species: 268886

189855
type: SpeciesReference
stoichiometry: 1.0
species: 268888

268888
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 1,3-diphosphateglycerate

189819
type: SpeciesReference
stoichiometry: 1.0
species: 268882

189867
type: SpeciesReference
stoichiometry: 1.0
species: 268890

268956
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 5-phosphoribosyl 1-pyrophosphate

268973
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: pyrroline 5-carboxylate

268991
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 3-isopropylmalate

269255
type: Reaction
product: 189734
product: 189722
reactant: 189710
reactant: 189698
notes: GENE_ASSOCIATION: ( SMGWSS_098_ilvE ) PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) PROTEIN_CLASS: 2.6.1.42 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: _2__45__KETOGLUTARATE SIDE: GLT COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Branched-chain amino acid aminotransferase

189734
type: SpeciesReference
stoichiometry: 1.0
species: 268913

268913
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-ketoisocaproate

189722
type: SpeciesReference
stoichiometry: 1.0
species: 268911

189710
type: SpeciesReference
stoichiometry: 1.0
species: 268909

268909
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-leucine

189698
type: SpeciesReference
stoichiometry: 1.0
species: 268907

269210
type: Reaction
product: 189034
product: 189022
reactant: 189010
reactant: 188998
notes: GENE_ASSOCIATION: ( SMGWSS_109 ) PROTEIN_ASSOCIATION: ( putative argininosuccinate synthase (argG)/acetyltransferase activity of N-acetylglutamate synthase (argA) ) PROTEIN_CLASS: 2.3.1.1 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: ACETYL__45__COA SIDE: CO__45__A COFACTOR: ACETYL__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Amino-acid N-acetyltransferase

189034
type: SpeciesReference
stoichiometry: 1.0
species: 268993

268993
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: N-acetyl-L-glutamate

189022
type: SpeciesReference
stoichiometry: 1.0
species: 268915

189010
type: SpeciesReference
stoichiometry: 1.0
species: 268911

188998
type: SpeciesReference
stoichiometry: 1.0
species: 268919

269100
type: Reaction
fast: false
notes: GENE_ASSOCIATION: ( SMGWSS_113_carB ) or ( SMGWSS_112_carA ) PROTEIN_ASSOCIATION: ( carbamyl phosphate synthase large subunit ) or ( carbamoyl phosphate synthase small subunit ) PROTEIN_CLASS: 6.3.5.5 SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: WATER SIDE: ATP SIDE: GLN SIDE: GLT SIDE: ADP SIDE: __124__Pi__124__ COFACTOR: ATP COFACTOR: ADP COFACTOR: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
reactant: 186991
reactant: 186979
reversible: false
name: carbamoyl-phosphate synthetase (glutamine-hydrolysing)
product: 187039
product: 187015
reactant: 186955
product: 187027
product: 187003
reactant: 186967

186991
type: SpeciesReference
stoichiometry: 1.0
species: 269087

269087
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: HCO3-

186979
type: SpeciesReference
stoichiometry: 1.0
species: 268939

268939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-glutamine

187039
type: SpeciesReference
stoichiometry: 1.0
species: 268886

187015
type: SpeciesReference
stoichiometry: 2.0
species: 269025

269025
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: ADP

186955
type: SpeciesReference
stoichiometry: 1.0
species: 268899

187027
type: SpeciesReference
stoichiometry: 1.0
species: 269006

269006
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: carbamoyl-phosphate

187003
type: SpeciesReference
stoichiometry: 1.0
species: 268911

186967
type: SpeciesReference
stoichiometry: 2.0
species: 269020

269020
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: ATP

269018
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: homoserine

269246
type: Reaction
product: 189589
product: 189577
reactant: 189565
reactant: 189553
notes: GENE_ASSOCIATION: ( SMGWSS_122 ) or ( SMGWSS_121_trpA ) PROTEIN_ASSOCIATION: ( putative tryptophan synthase, beta subunit (trpB)/anthranilate isomerase activity of trpC (trpF) ) or ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase ) PROTEIN_CLASS: 4.2.1.20 SUBSYSTEM: tryptophan biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

189589
type: SpeciesReference
stoichiometry: 1.0
species: 268899

189577
type: SpeciesReference
stoichiometry: 1.0
species: 268936

189565
type: SpeciesReference
stoichiometry: 1.0
species: 268934

189553
type: SpeciesReference
stoichiometry: 1.0
species: 268932

268932
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: indole

269136
type: Reaction
notes: GENE_ASSOCIATION: ( SMGWSS_200 ) PROTEIN_ASSOCIATION: ( putative phospho-2-dehydro-3-deoxyheptonate aldolase (aroG)/chorismate mutase (pheA) ) PROTEIN_CLASS: 2.5.1.54 SUBSYSTEM: chorismate biosynthesis SIDE: WATER SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
product: 187684
fast: false
reactant: 187660
product: 187672
reactant: 187648
name: 2-dehydro-3-deoxyphosphoheptonate aldolase
reversible: false
reactant: 187636

187684
type: SpeciesReference
stoichiometry: 1.0
species: 268962

268962
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 3-deoxy-D-arabino-heptulosonate-7-phosphate

187660
type: SpeciesReference
stoichiometry: 1.0
species: 268924

268924
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: phosphoenolpyruvate

187672
type: SpeciesReference
stoichiometry: 1.0
species: 268886

187648
type: SpeciesReference
stoichiometry: 1.0
species: 268899

187636
type: SpeciesReference
stoichiometry: 1.0
species: 269079

269079
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: D-erythrose-4-phosphate

269077
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: phenylpyruvate

269154
type: Reaction
product: 188046
product: 188034
reactant: 188022
reactant: 188010
notes: GENE_ASSOCIATION: ( SMGWSS_098_ilvE ) PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) PROTEIN_CLASS: 2.6.1.42 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: _2__45__KETOGLUTARATE COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Branched-chain amino acid aminotransferase

188046
type: SpeciesReference
stoichiometry: 1.0
species: 268905

268905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-keto-3-methyl-valerate

188034
type: SpeciesReference
stoichiometry: 1.0
species: 268911

188022
type: SpeciesReference
stoichiometry: 1.0
species: 269066

269066
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-isoleucine

188010
type: SpeciesReference
stoichiometry: 1.0
species: 268907

269207
type: Reaction
product: 188986
product: 188974
reactant: 188962
reactant: 188950
notes: GENE_ASSOCIATION: ( SMGWSS_180_aroE ) PROTEIN_ASSOCIATION: ( putative shikimate 5-dehydrogenase ) PROTEIN_CLASS: 1.1.1.25 SUBSYSTEM: chorismate biosynthesis SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Shikimate 5-dehydrogenase

188986
type: SpeciesReference
stoichiometry: 1.0
species: 269003

188974
type: SpeciesReference
stoichiometry: 1.0
species: 269000

269000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: shikimate

188962
type: SpeciesReference
stoichiometry: 1.0
species: 268998

188950
type: SpeciesReference
stoichiometry: 1.0
species: 268995

268995
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 3-dehydro-shikimate

269095
type: Reaction
product: 186882
product: 186870
reactant: 186857
reactant: 186845
notes: GENE_ASSOCIATION: ( SMGWSS_210_aspC ) PROTEIN_ASSOCIATION: ( putative aspartate aminotransferase ) PROTEIN_CLASS: 2.6.1.57 SUBSYSTEM: phenylalanine biosynthesis I SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Aromatic amino acid transferase

186882
type: SpeciesReference
stoichiometry: 1.0
species: 269090

186870
type: SpeciesReference
stoichiometry: 1.0
species: 268907

186857
type: SpeciesReference
stoichiometry: 1.0
species: 269077

186845
type: SpeciesReference
stoichiometry: 1.0
species: 268911

269146
type: Reaction
fast: false
reactant: 187866
product: 187890
product: 187902
reversible: false
product: 187914
reactant: 187878
notes: GENE_ASSOCIATION: ( SMGWSS_202_asd ) PROTEIN_ASSOCIATION: ( aspartate semialdehyde dehydrogenase ) PROTEIN_CLASS: 1.2.1.11 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: homoserine biosynthesis SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: NADPH SIDE: __124__Pi__124__ SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
name: Aspartate-semialdehyde dehydrogenase

187866
type: SpeciesReference
stoichiometry: 1.0
species: 269047

269047
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-aspartyl-4-phosphate

187890
type: SpeciesReference
stoichiometry: 1.0
species: 268886

187902
type: SpeciesReference
stoichiometry: 1.0
species: 269028

187914
type: SpeciesReference
stoichiometry: 1.0
species: 269003

187878
type: SpeciesReference
stoichiometry: 1.0
species: 268998

269143
type: Reaction
notes: GENE_ASSOCIATION: ( SMGWSS_109 ) PROTEIN_ASSOCIATION: ( putative argininosuccinate synthase (argG)/acetyltransferase activity of N-acetylglutamate synthase (argA) ) PROTEIN_CLASS: 6.3.4.5 SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: ATP SIDE: L__45__ASPARTATE SIDE: AMP SIDE: PPI COFACTOR: ATP COFACTOR: AMP COFACTOR: PPI GENERIC: false TYPE: small HOLE: false
name: argininosuccinate synthetase
product: 187842
reversible: false
fast: false
reactant: 187818
product: 187854
reactant: 187806
reactant: 187794
product: 187830

187842
type: SpeciesReference
stoichiometry: 1.0
species: 268958

268958
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: diphosphate

187818
type: SpeciesReference
stoichiometry: 1.0
species: 269045

187854
type: SpeciesReference
stoichiometry: 1.0
species: 268893

268893
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-arginino-succinate

187806
type: SpeciesReference
stoichiometry: 1.0
species: 269057

187794
type: SpeciesReference
stoichiometry: 1.0
species: 269020

187830
type: SpeciesReference
stoichiometry: 1.0
species: 269059

269059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: AMP

269195
type: Reaction
product: 188793
product: 188781
reactant: 188769
reactant: 188757
notes: GENE_ASSOCIATION: ( SMGWSS_262_ilvC ) PROTEIN_ASSOCIATION: ( ketol-acid reductoisomerase ) PROTEIN_CLASS: 1.1.1.86 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: NADPH SIDE: NADP COFACTOR: NADPH COFACTOR: NADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Ketol-acid reductoisomerase

188793
type: SpeciesReference
stoichiometry: 1.0
species: 268902

268902
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2,3-dihydroxy-3-methylvalerate

188781
type: SpeciesReference
stoichiometry: 1.0
species: 269003

188769
type: SpeciesReference
stoichiometry: 1.0
species: 268877

188757
type: SpeciesReference
stoichiometry: 1.0
species: 268998

269081
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-valine

269258
type: Reaction
product: 189770
product: 189758
reactant: 189746
notes: GENE_ASSOCIATION: ( SMGWSS_265_ilvD ) PROTEIN_ASSOCIATION: ( dihydroxy-acid dehydratase ) PROTEIN_CLASS: 4.2.1.9 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydroxy-acid dehydratase

189770
type: SpeciesReference
stoichiometry: 1.0
species: 268899

189758
type: SpeciesReference
stoichiometry: 1.0
species: 268905

189746
type: SpeciesReference
stoichiometry: 1.0
species: 268902

269148
type: Reaction
product: 187950
product: 187938
reactant: 187926
notes: GENE_ASSOCIATION: ( SMGWSS_130_lysA ) PROTEIN_ASSOCIATION: ( diaminopimelate decarboxylase ) PROTEIN_CLASS: 4.1.1.20 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Diaminopimelate decarboxylase

187950
type: SpeciesReference
stoichiometry: 1.0
species: 268880

187938
type: SpeciesReference
stoichiometry: 1.0
species: 269072

269072
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-lysine

187926
type: SpeciesReference
stoichiometry: 1.0
species: 268989

268989
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: meso-diaminopimelate

269120
type: Reaction
reactant: 187367
fast: false
product: 187393
reversible: false
reactant: 187354
name: 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase
reactant: 187342
product: 187380
notes: GENE_ASSOCIATION: ( SMGWSS_097_dapD ) PROTEIN_ASSOCIATION: ( 2, 3, 4, 5-tetrahydropyridine-2, 6-dicarboxylate ) PROTEIN_CLASS: 2.3.1.117 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: SUC__45__COA SIDE: WATER SIDE: CO__45__A COFACTOR: SUC__45__COA COFACTOR: CO__45__A GENERIC: false TYPE: small HOLE: false

187367
type: SpeciesReference
stoichiometry: 1.0
species: 268899

187393
type: SpeciesReference
stoichiometry: 1.0
species: 269032

187354
type: SpeciesReference
stoichiometry: 1.0
species: 268951

268951
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: tetrahydrodipicolinate

187342
type: SpeciesReference
stoichiometry: 1.0
species: 268917

268917
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: succinyl-CoA

187380
type: SpeciesReference
stoichiometry: 1.0
species: 268915

268895
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-arginine

269070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: D-ribose-5-phosphate

269037
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: S-adenosyl-L-methionine

269102
type: Reaction
product: 187088
reactant: 187063
product: 187075
name: 3-isopropylmalate dehydrogenase
reversible: false
fast: false
reactant: 187051
notes: GENE_ASSOCIATION: ( SMGWSS_040_leuB ) PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydrogenase ) PROTEIN_CLASS: 1.1.1.85 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: NAD SIDE: PROTON SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
product: 187100

187088
type: SpeciesReference
stoichiometry: 1.0
species: 268944

187063
type: SpeciesReference
stoichiometry: 1.0
species: 268991

187075
type: SpeciesReference
stoichiometry: 1.0
species: 269084

269084
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 2-isopropyl-3-oxosuccinate

187051
type: SpeciesReference
stoichiometry: 1.0
species: 268884

187100
type: SpeciesReference
stoichiometry: 1.0
species: 268890

268964
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 3-dehydroquinate

269201
type: Reaction
product: 188902
product: 188890
reactant: 188878
reactant: 188866
notes: GENE_ASSOCIATION: ( SMGWSS_114_argF ) PROTEIN_ASSOCIATION: ( putative ornithine carbamoyltransferase ) PROTEIN_CLASS: 2.1.3.9 SUBSYSTEM: arginine biosynthesis III SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

188902
type: SpeciesReference
stoichiometry: 1.0
species: 268886

188890
type: SpeciesReference
stoichiometry: 1.0
species: 269011

188878
type: SpeciesReference
stoichiometry: 1.0
species: 269009

188866
type: SpeciesReference
stoichiometry: 1.0
species: 269006

268982
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 1,4-dihydroxy-2-naphthoate

268948
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NAD(P)H

269138
type: Reaction
product: 187733
product: 187721
reactant: 187709
reactant: 187697
notes: GENE_ASSOCIATION: ( SMGWSS_114_argF ) PROTEIN_ASSOCIATION: ( putative ornithine carbamoyltransferase ) PROTEIN_CLASS: 2.1.3.3 SUBSYSTEM: citrulline degradation SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Ornithine carbamoyltransferase

187733
type: SpeciesReference
stoichiometry: 1.0
species: 269057

187721
type: SpeciesReference
stoichiometry: 1.0
species: 268886

187709
type: SpeciesReference
stoichiometry: 1.0
species: 269055

187697
type: SpeciesReference
stoichiometry: 1.0
species: 269006

269192
type: Reaction
product: 188745
product: 188733
reactant: 188721
reactant: 188709
notes: GENE_ASSOCIATION: ( SMGWSS_140_thrB ) PROTEIN_ASSOCIATION: ( homoserine kinase ) PROTEIN_CLASS: 2.7.1.39 SUBSYSTEM: threonine biosynthesis from homoserine SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Homoserine kinase

188745
type: SpeciesReference
stoichiometry: 1.0
species: 269025

188733
type: SpeciesReference
stoichiometry: 1.0
species: 269022

188721
type: SpeciesReference
stoichiometry: 1.0
species: 269020

188709
type: SpeciesReference
stoichiometry: 1.0
species: 269018

268953
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: NAD(P)+

268971
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-glutamate &gamma;-semialdehyde

269115
type: Reaction
product: 187306
product: 187294
reactant: 187282
notes: GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: NA SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: CARBON__45__DIOXIDE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

187306
type: SpeciesReference
stoichiometry: 1.0
species: 268880

187294
type: SpeciesReference
stoichiometry: 1.0
species: 268913

187282
type: SpeciesReference
stoichiometry: 1.0
species: 269084

269151
type: Reaction
product: 187998
product: 187986
reactant: 187974
reactant: 187962
notes: GENE_ASSOCIATION: ( SMGWSS_028_prsA ) PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase ) PROTEIN_CLASS: 2.7.6.1 SUBSYSTEM: PRPP biosynthesis I SIDE: ATP COFACTOR: ATP COFACTOR: AMP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: ribose-phosphate diphosphokinase

187998
type: SpeciesReference
stoichiometry: 1.0
species: 268956

187986
type: SpeciesReference
stoichiometry: 1.0
species: 269059

187974
type: SpeciesReference
stoichiometry: 1.0
species: 269070

187962
type: SpeciesReference
stoichiometry: 1.0
species: 269020

269240
type: Reaction
reactant: 189445
reversible: false
product: 189469
reactant: 189433
name: Dihydrodipicolinate reductase
notes: GENE_ASSOCIATION: ( SMGWSS_177_dapB ) PROTEIN_ASSOCIATION: ( dihydrodipicolinate reductase ) PROTEIN_CLASS: 1.3.1.26 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
fast: false
reactant: 189457
product: 189481

189445
type: SpeciesReference
stoichiometry: 1.0
species: 268946

268946
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: L-2,3-dihydrodipicolinate

189469
type: SpeciesReference
stoichiometry: 1.0
species: 268951

189433
type: SpeciesReference
stoichiometry: 1.0
species: 268944

189457
type: SpeciesReference
stoichiometry: 1.0
species: 268948

189481
type: SpeciesReference
stoichiometry: 1.0
species: 268953

269176
type: Reaction
product: 188432
product: 188420
reactant: 188408
reactant: 188396
notes: GENE_ASSOCIATION: ( SMGWSS_141_thrA ) or ( SMGWSS_038_lysC ) PROTEIN_ASSOCIATION: ( aspartokinase/homoserine dehydrogenase ) or ( putative aspartate kinase ) PROTEIN_CLASS: 2.7.2.4 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: homoserine biosynthesis SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Aspartate kinase

188432
type: SpeciesReference
stoichiometry: 1.0
species: 269047

188420
type: SpeciesReference
stoichiometry: 1.0
species: 269025

188408
type: SpeciesReference
stoichiometry: 1.0
species: 269020

188396
type: SpeciesReference
stoichiometry: 1.0
species: 269045

269222
type: Reaction
name: NA
reactant: 189167
fast: false
reversible: false
product: 189216
reactant: 189179
notes: GENE_ASSOCIATION: ( SMGWSS_138_menA ) PROTEIN_ASSOCIATION: ( 1,4-dihydroxy-2-naphthoate octaprenyltransferase ) PROTEIN_CLASS: 2.5.1.- SUBSYSTEM: menaquinone biosynthesis SIDE: CARBON__45__DIOXIDE SIDE: PPI GENERIC: false TYPE: small HOLE: false
product: 189192
product: 189204

189167
type: SpeciesReference
stoichiometry: 1.0
species: 268980

268980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: all-trans-octaprenyl diphosphate

189216
type: SpeciesReference
stoichiometry: 1.0
species: 268984

189179
type: SpeciesReference
stoichiometry: 1.0
species: 268982

189192
type: SpeciesReference
stoichiometry: 1.0
species: 268880

189204
type: SpeciesReference
stoichiometry: 1.0
species: 268958

269112
type: Reaction
product: 187270
product: 187258
reactant: 187246
reactant: 187234
notes: GENE_ASSOCIATION: ( SMGWSS_111_argD ) PROTEIN_ASSOCIATION: ( acetylornithine aminotransferase ) PROTEIN_CLASS: 2.6.1.11 COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Acetylornithine aminotransferase

187270
type: SpeciesReference
stoichiometry: 1.0
species: 268911

187258
type: SpeciesReference
stoichiometry: 1.0
species: 268971

187246
type: SpeciesReference
stoichiometry: 1.0
species: 268907

187234
type: SpeciesReference
stoichiometry: 1.0
species: 269055

269186
type: Reaction
fast: false
reversible: false
reactant: 188588
reactant: 188600
product: 188612
product: 188624
reactant: 188576
name: Homoserine dehydrogenase
notes: GENE_ASSOCIATION: ( SMGWSS_141_thrA ) PROTEIN_ASSOCIATION: ( aspartokinase/homoserine dehydrogenase ) PROTEIN_CLASS: 1.1.1.3 SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: homoserine biosynthesis SUBSYSTEM: threonine biosynthesis SUBSYSTEM: isoleucine biosynthesis I SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP SIDE: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false

188588
type: SpeciesReference
stoichiometry: 1.0
species: 269028

188600
type: SpeciesReference
stoichiometry: 1.0
species: 268948

188612
type: SpeciesReference
stoichiometry: 1.0
species: 268953

188624
type: SpeciesReference
stoichiometry: 1.0
species: 269018

188576
type: SpeciesReference
stoichiometry: 1.0
species: 268944

269042
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: menaquinone-8

269219
type: Reaction
product: 189155
reactant: 189143
notes: GENE_ASSOCIATION: ( SMGWSS_247_dapF ) PROTEIN_ASSOCIATION: ( diaminopimelate epimerase ) PROTEIN_CLASS: 5.1.1.7 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Diaminopimelate epimerase

189155
type: SpeciesReference
stoichiometry: 1.0
species: 268989

189143
type: SpeciesReference
stoichiometry: 1.0
species: 268986

269181
type: Reaction
product: 188528
product: 188516
reactant: 188504
reactant: 188492
notes: GENE_ASSOCIATION: ( SMGWSS_111_argD ) PROTEIN_ASSOCIATION: ( acetylornithine aminotransferase ) PROTEIN_CLASS: 2.6.1.17 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: GLT SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Succinyldiaminopimelate aminotransferase

188528
type: SpeciesReference
stoichiometry: 1.0
species: 269035

188516
type: SpeciesReference
stoichiometry: 1.0
species: 268907

188504
type: SpeciesReference
stoichiometry: 1.0
species: 269032

188492
type: SpeciesReference
stoichiometry: 1.0
species: 268911

269249
type: Reaction
product: 189638
product: 189625
product: 189613
reactant: 189601
notes: GENE_ASSOCIATION: ( SMGWSS_123_trpC ) PROTEIN_ASSOCIATION: ( indole-3-glycerol phosphate synthase activity of trpC ) PROTEIN_CLASS: 4.1.1.48 SUBSYSTEM: tryptophan biosynthesis SIDE: CARBON__45__DIOXIDE SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: indole-3-glycerol-phosphate synthase

189638
type: SpeciesReference
stoichiometry: 1.0
species: 268899

189625
type: SpeciesReference
stoichiometry: 1.0
species: 268880

189613
type: SpeciesReference
stoichiometry: 1.0
species: 268930

189601
type: SpeciesReference
stoichiometry: 1.0
species: 268928

268928
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-phosphate

268941
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: anthranilate

269165
type: Reaction
reactant: 188215
fast: false
notes: GENE_ASSOCIATION: ( SMGWSS_249_putA ) PROTEIN_ASSOCIATION: ( putative delta-1-pyrroline-5-carboxylate dehydrogenase//1-pyrroline-5-carboxylate dehydrogenase ) PROTEIN_CLASS: 1.5.1.12 SUBSYSTEM: proline degradation I SUBSYSTEM: arginine degradation I (arginase pathway) SIDE: NAD SIDE: WATER SIDE: NADH COFACTOR: NAD COFACTOR: NADH GENERIC: false TYPE: small HOLE: false
reactant: 188191
name: 1-pyrroline-5-carboxylate dehydrogenase
reactant: 188203
product: 188239
product: 188227
reversible: false

188215
type: SpeciesReference
stoichiometry: 1.0
species: 268973

188191
type: SpeciesReference
stoichiometry: 1.0
species: 268884

188203
type: SpeciesReference
stoichiometry: 2.0
species: 268899

188239
type: SpeciesReference
stoichiometry: 1.0
species: 268890

188227
type: SpeciesReference
stoichiometry: 1.0
species: 268911

269252
type: Reaction
product: 189686
product: 189674
reactant: 189662
reactant: 189650
notes: GENE_ASSOCIATION: ( SMGWSS_205_aroA ) PROTEIN_ASSOCIATION: ( 3-phosphoshikimate 1-carboxyvinyltransferase ) PROTEIN_CLASS: 2.5.1.19 SUBSYSTEM: chorismate biosynthesis SIDE: PHOSPHO__45__ENOL__45__PYRUVATE SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-phosphoshikimate 1-carboxyvinyltransferase

189686
type: SpeciesReference
stoichiometry: 1.0
species: 268886

189674
type: SpeciesReference
stoichiometry: 1.0
species: 268926

189662
type: SpeciesReference
stoichiometry: 1.0
species: 268924

189650
type: SpeciesReference
stoichiometry: 1.0
species: 268921

268921
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: shikimate-3-phosphate

269237
type: Reaction
product: 189420
product: 189408
reactant: 189396
reactant: 189384
notes: GENE_ASSOCIATION: ( SMGWSS_124_trpG ) PROTEIN_ASSOCIATION: ( anthranilate phosphoribosyltransferase ) PROTEIN_CLASS: 2.4.2.18 SUBSYSTEM: tryptophan biosynthesis SIDE: PRPP SIDE: PPI GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Anthranilate phosphoribosyltransferase

189420
type: SpeciesReference
stoichiometry: 1.0
species: 268960

189408
type: SpeciesReference
stoichiometry: 1.0
species: 268958

189396
type: SpeciesReference
stoichiometry: 1.0
species: 268941

189384
type: SpeciesReference
stoichiometry: 1.0
species: 268956

269117
type: Reaction
product: 187330
reactant: 187318
notes: GENE_ASSOCIATION: ( SMGWSS_122 ) PROTEIN_ASSOCIATION: ( putative tryptophan synthase, beta subunit (trpB)/anthranilate isomerase activity of trpC (trpF) ) PROTEIN_CLASS: 5.3.1.24 SUBSYSTEM: tryptophan biosynthesis GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Phosphoribosylanthranilate isomerase

187330
type: SpeciesReference
stoichiometry: 1.0
species: 268928

187318
type: SpeciesReference
stoichiometry: 1.0
species: 268960

269234
type: Reaction
product: 189372
product: 189360
reactant: 189348
notes: GENE_ASSOCIATION: ( SMGWSS_007_aroB ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate synthase ) PROTEIN_CLASS: 4.2.3.4 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-dehydroquinate synthase

189372
type: SpeciesReference
stoichiometry: 1.0
species: 268886

189360
type: SpeciesReference
stoichiometry: 1.0
species: 268964

189348
type: SpeciesReference
stoichiometry: 1.0
species: 268962

269178
type: Reaction
product: 188480
product: 188468
reactant: 188456
reactant: 188444
notes: GENE_ASSOCIATION: ( SMGWSS_216_ubiE ) PROTEIN_ASSOCIATION: ( ubiquinone/menaquinone biosynthesis methyltransferase ) PROTEIN_CLASS: 2.1.1.- SUBSYSTEM: menaquinone biosynthesis SIDE: S__45__ADENOSYLMETHIONINE SIDE: ADENOSYL__45__HOMO__45__CYS COFACTOR: S__45__ADENOSYLMETHIONINE COFACTOR: ADENOSYL__45__HOMO__45__CYS GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

188480
type: SpeciesReference
stoichiometry: 1.0
species: 269042

188468
type: SpeciesReference
stoichiometry: 1.0
species: 269039

188456
type: SpeciesReference
stoichiometry: 1.0
species: 269037

188444
type: SpeciesReference
stoichiometry: 1.0
species: 268984

269107
type: Reaction
product: 187173
product: 187161
reactant: 187149
reactant: 187137
notes: GENE_ASSOCIATION: ( SMGWSS_111_argD ) PROTEIN_ASSOCIATION: ( acetylornithine aminotransferase ) PROTEIN_CLASS: 2.6.1.11 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: _2__45__KETOGLUTARATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetylornithine aminotransferase

187173
type: SpeciesReference
stoichiometry: 1.0
species: 268907

187161
type: SpeciesReference
stoichiometry: 1.0
species: 269009

187149
type: SpeciesReference
stoichiometry: 1.0
species: 269015

187137
type: SpeciesReference
stoichiometry: 1.0
species: 268911

269105
type: Reaction
product: 187124
reactant: 187112
notes: GENE_ASSOCIATION: ( SMGWSS_201_pheA ) PROTEIN_ASSOCIATION: ( putative prephenate dehydratase ) PROTEIN_CLASS: 5.4.99.5 SUBSYSTEM: phenylalanine biosynthesis I GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Chorismate mutase

187124
type: SpeciesReference
stoichiometry: 1.0
species: 269075

269075
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: prephenate

187112
type: SpeciesReference
stoichiometry: 1.0
species: 268937

269128
type: Reaction
product: 187516
product: 187504
reactant: 187492
notes: GENE_ASSOCIATION: ( SMGWSS_132_aroC ) PROTEIN_ASSOCIATION: ( Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase)//CHORISMATE-SYNTHASE-RXN//Chorismate synthase ) PROTEIN_CLASS: 4.2.3.5 SUBSYSTEM: chorismate biosynthesis SIDE: __124__Pi__124__ GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Chorismate synthase

187516
type: SpeciesReference
stoichiometry: 1.0
species: 268937

187504
type: SpeciesReference
stoichiometry: 1.0
species: 268886

187492
type: SpeciesReference
stoichiometry: 1.0
species: 268926

269243
type: Reaction
fast: false
reactant: 189493
product: 189541
product: 189529
reactant: 189505
name: Anthranilate synthase
reversible: false
notes: GENE_ASSOCIATION: ( SMGWSS_126_trpE ) or ( SMGWSS_125_trpD ) PROTEIN_ASSOCIATION: ( anthranilate synthase component I ) or ( anthranilate synthase component II ) PROTEIN_CLASS: 4.1.3.27 SUBSYSTEM: tryptophan biosynthesis SIDE: GLN SIDE: GLT SIDE: PYRUVATE GENERIC: false TYPE: small HOLE: false
product: 189517

189493
type: SpeciesReference
stoichiometry: 1.0
species: 268937

189541
type: SpeciesReference
stoichiometry: 1.0
species: 268875

189529
type: SpeciesReference
stoichiometry: 1.0
species: 268911

189505
type: SpeciesReference
stoichiometry: 1.0
species: 268939

189517
type: SpeciesReference
stoichiometry: 1.0
species: 268941

269228
type: Reaction
product: 189300
product: 189288
reactant: 189276
notes: GENE_ASSOCIATION: NA PROTEIN_ASSOCIATION: NA PROTEIN_CLASS: NA SUBSYSTEM: arginine degradation I (arginase pathway) SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: NA

189300
type: SpeciesReference
stoichiometry: 1.0
species: 268899

189288
type: SpeciesReference
stoichiometry: 1.0
species: 268973

189276
type: SpeciesReference
stoichiometry: 1.0
species: 268971

269261
type: Reaction
product: 189807
product: 189795
reactant: 189783
notes: GENE_ASSOCIATION: ( SMGWSS_252_argH ) PROTEIN_ASSOCIATION: ( argininosuccinate lyase ) PROTEIN_CLASS: 4.3.2.1 SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: FUM GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Argininosuccinate lyase

189807
type: SpeciesReference
stoichiometry: 1.0
species: 268897

189795
type: SpeciesReference
stoichiometry: 1.0
species: 268895

189783
type: SpeciesReference
stoichiometry: 1.0
species: 268893

269231
type: Reaction
product: 189336
product: 189324
reactant: 189312
notes: GENE_ASSOCIATION: ( SMGWSS_265_ilvD ) PROTEIN_ASSOCIATION: ( dihydroxy-acid dehydratase ) PROTEIN_CLASS: 4.2.1.9 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: valine biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Dihydroxy-acid dehydratase

189336
type: SpeciesReference
stoichiometry: 1.0
species: 268969

189324
type: SpeciesReference
stoichiometry: 1.0
species: 268899

189312
type: SpeciesReference
stoichiometry: 1.0
species: 268966

269064
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: 268873
name: ammonia

269109
type: Reaction
product: 187222
product: 187210
reactant: 187198
reactant: 187186
notes: GENE_ASSOCIATION: ( SMGWSS_115_argB ) PROTEIN_ASSOCIATION: ( acetylglutamate kinase ) PROTEIN_CLASS: 2.7.2.8 SUBSYSTEM: ornithine biosynthesis SUBSYSTEM: arginine biosynthesis I SUBSYSTEM: arginine biosynthesis III SUBSYSTEM: arginine biosynthesis II (acetyl cycle) SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Acetylglutamate kinase

187222
type: SpeciesReference
stoichiometry: 1.0
species: 269025

187210
type: SpeciesReference
stoichiometry: 1.0
species: 269013

187198
type: SpeciesReference
stoichiometry: 1.0
species: 269020

187186
type: SpeciesReference
stoichiometry: 1.0
species: 268993

269157
type: Reaction
product: 188094
product: 188082
reactant: 188070
reactant: 188058
notes: GENE_ASSOCIATION: ( SMGWSS_174_dapA ) PROTEIN_ASSOCIATION: ( Dihydrodipicolinate synthase (DHDPS)//DIHYDRODIPICSYN-RXN//Dihydrodipicolinate synthase ) PROTEIN_CLASS: 4.2.1.52 SUBSYSTEM: lysine biosynthesis I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SIDE: PYRUVATE SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: dihydrodipicolinate synthase

188094
type: SpeciesReference
stoichiometry: 1.0
species: 268946

188082
type: SpeciesReference
stoichiometry: 2.0
species: 268899

188070
type: SpeciesReference
stoichiometry: 1.0
species: 268875

188058
type: SpeciesReference
stoichiometry: 1.0
species: 269028

269140
type: Reaction
product: 187782
product: 187770
product: 187758
reactant: 187746
notes: GENE_ASSOCIATION: ( SMGWSS_201_pheA ) PROTEIN_ASSOCIATION: ( putative prephenate dehydratase ) PROTEIN_CLASS: 4.2.1.51 SUBSYSTEM: phenylalanine biosynthesis I SIDE: CARBON__45__DIOXIDE SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Prephenate dehydratase

187782
type: SpeciesReference
stoichiometry: 1.0
species: 268899

187770
type: SpeciesReference
stoichiometry: 1.0
species: 269077

187758
type: SpeciesReference
stoichiometry: 1.0
species: 268880

187746
type: SpeciesReference
stoichiometry: 1.0
species: 269075

269123
type: Reaction
product: 187431
product: 187419
reactant: 187406
notes: GENE_ASSOCIATION: ( SMGWSS_014_aroD ) PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase ) PROTEIN_CLASS: 4.2.1.10 SUBSYSTEM: chorismate biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-dehydroquinate dehydratase

187431
type: SpeciesReference
stoichiometry: 1.0
species: 268899

187419
type: SpeciesReference
stoichiometry: 1.0
species: 268995

187406
type: SpeciesReference
stoichiometry: 1.0
species: 268964

269162
type: Reaction
product: 188179
product: 188167
reactant: 188154
reactant: 188142
notes: GENE_ASSOCIATION: ( SMGWSS_119_aroK ) PROTEIN_ASSOCIATION: ( shikimate kinase ) PROTEIN_CLASS: 2.7.1.71 SUBSYSTEM: chorismate biosynthesis SIDE: ATP SIDE: ADP COFACTOR: ATP COFACTOR: ADP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: shikimate-kinase

188179
type: SpeciesReference
stoichiometry: 1.0
species: 268921

188167
type: SpeciesReference
stoichiometry: 1.0
species: 269025

188154
type: SpeciesReference
stoichiometry: 1.0
species: 269020

188142
type: SpeciesReference
stoichiometry: 1.0
species: 269000

269216
type: Reaction
product: 189131
reactant: 189119
reactant: 189107
notes: GENE_ASSOCIATION: ( SMGWSS_042_leuC ) or ( SMGWSS_041_leuD ) PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydratase large subunit ) or ( 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)//3-ISOPROPYLMALISOM-RXN//3-isopropylmalate dehydratase ) PROTEIN_CLASS: 4.2.1.33 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: leucine biosynthesis SIDE: WATER GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: 3-isopropylmalate dehydratase

189131
type: SpeciesReference
stoichiometry: 1.0
species: 268991

189119
type: SpeciesReference
stoichiometry: 1.0
species: 268899

189107
type: SpeciesReference
stoichiometry: 1.0
species: 268978

269159
type: Reaction
product: 188130
product: 188118
reactant: 188106
notes: GENE_ASSOCIATION: ( SMGWSS_261_ilvA ) PROTEIN_ASSOCIATION: ( threonine dehydratase ) PROTEIN_CLASS: 4.3.1.19 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: isoleucine biosynthesis from threonine SUBSYSTEM: isoleucine biosynthesis I SIDE: AMMONIA GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: Threonine dehydratase

188130
type: SpeciesReference
stoichiometry: 1.0
species: 268874

188118
type: SpeciesReference
stoichiometry: 1.0
species: 269064

188106
type: SpeciesReference
stoichiometry: 1.0
species: 269061

269091
type: Reaction
product: 186783
product: 186770
reactant: 186758
reactant: 186746
notes: GENE_ASSOCIATION: ( GO2720342 ) PROTEIN_ASSOCIATION: ( GO2720342-MONOMER ) SUBSYSTEM: aspartate degradation I SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I SUBSYSTEM: threonine biosynthesis SUBSYSTEM: aspartate biosynthesis SUBSYSTEM: isoleucine biosynthesis I PROTEIN_CLASS: 2.6.1.1 COFACTOR: OXALACETIC_ACID COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT COFACTOR: L__45__ASPARTATE GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Aspartate aminotransferase

186783
type: SpeciesReference
stoichiometry: 1.0
species: 268911

186770
type: SpeciesReference
stoichiometry: 1.0
species: 269049

186758
type: SpeciesReference
stoichiometry: 1.0
species: 269045

186746
type: SpeciesReference
stoichiometry: 1.0
species: 268907

269204
type: Reaction
product: 188938
product: 188926
reactant: 188914
notes: GENE_ASSOCIATION: ( SMGWSS_121_trpA ) PROTEIN_ASSOCIATION: ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase ) PROTEIN_CLASS: NA SUBSYSTEM: tryptophan biosynthesis SIDE: GAP GENERIC: false TYPE: small HOLE: false
fast: false
reversible: false
name: NA

188938
type: SpeciesReference
stoichiometry: 1.0
species: 268932

188926
type: SpeciesReference
stoichiometry: 1.0
species: 268882

188914
type: SpeciesReference
stoichiometry: 1.0
species: 268930

269133
type: Reaction
product: 187624
product: 187612
reactant: 187600
reactant: 187588
notes: GENE_ASSOCIATION: ( SMGWSS_098_ilvE ) PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) PROTEIN_CLASS: 2.6.1.42 SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis SUBSYSTEM: valine biosynthesis SIDE: _2__45__KETOGLUTARATE SIDE: GLT COFACTOR: _2__45__KETOGLUTARATE COFACTOR: GLT GENERIC: false TYPE: small HOLE: false
fast: false
reversible: true
name: Branched-chain amino acid aminotransferase

187624
type: SpeciesReference
stoichiometry: 1.0
species: 268911

187612
type: SpeciesReference
stoichiometry: 1.0
species: 268969

187600
type: SpeciesReference
stoichiometry: 1.0
species: 269081

187588
type: SpeciesReference
stoichiometry: 1.0
species: 268907

269189
type: Reaction
reactant: 188661
product: 188697
fast: false
reactant: 188636
name: NA
reactant: 188648
notes: GENE_ASSOCIATION: ( SMGWSS_249_putA ) PROTEIN_ASSOCIATION: ( putative delta-1-pyrroline-5-carboxylate dehydrogenase//1-pyrroline-5-carboxylate dehydrogenase ) PROTEIN_CLASS: 1.5.1.12 SIDE: NAD__45__P__45__OR__45__NOP SIDE: WATER SIDE: PROTON SIDE: NADH__45__P__45__OR__45__NOP COFACTOR: NAD__45__P__45__OR__45__NOP COFACTOR: NADH__45__P__45__OR__45__NOP GENERIC: true TYPE: small HOLE: false
product: 188673
product: 188685
reversible: false

188661
type: SpeciesReference
stoichiometry: 1.0
species: 268899

188697
type: SpeciesReference
stoichiometry: 1.0
species: 268911

188636
type: SpeciesReference
stoichiometry: 1.0
species: 268953

188648
type: SpeciesReference
stoichiometry: 1.0
species: 268973

188673
type: SpeciesReference
stoichiometry: 1.0
species: 268944

188685
type: SpeciesReference
stoichiometry: 1.0
species: 268948