MODEL1011010000
type: SBMLModel
species: metaid BPG
created:
  W3 CDTF: Tue Oct 26 01:00:00 BST 2010
reaction: metaid vTCA
species: metaid ADP
modified:
  W3 CDTF: Fri Feb 03 13:24:37 GMT 2012
species: metaid PEP
species: metaid F16P
species: metaid GLY
reaction: metaid vPGK
modified:
  W3 CDTF: Fri Feb 03 13:24:37 GMT 2012
units def: 165686
reaction: metaid vALD
is described by: http://identifiers.org/pubmed/19425118
species: metaid P3G
units def: 165662
reaction: metaid vPGM
species: metaid F6P
reaction: metaid vADH
species: metaid CO2
reaction: metaid vPDC
reaction: metaid vFBP
modified:
  W3 CDTF: Fri Feb 03 13:24:37 GMT 2012
creator:
  ORG:
    orgname: Humboldt-Universitat zu Berlin
  n:
    given: Jozsef
    family: Bruck
units def: 165614
creator:
  ORG:
    orgname: University of Manchester
  n:
    given: Kieran
    family: Smallbone
reaction: metaid GLYtrs
reaction: metaid vGLT
species: metaid GLCo
reaction: metaid vAdKin
species: metaid G6P
creator:
  ORG:
    orgname: Humboldt-Universitat zu Berlin
  n:
    given: Jozsef
    family: Bruck
creator:
  ORG:
    orgname: University of Manchester
  n:
    given: Kieran
    family: Smallbone
reaction: metaid vRESP
units def: 165782
compartment: metaid cell
notes: Exploring the effect of variable enzyme concentrations in a kinetic model of yeast glycolysis Jozsef Bruck, Wolfram Liebermeister, Edda Klipp, Genome Inform 2008 20:1-14 Abstract: Metabolism is one of the best studied fields of biochemistry, but its regulation involves processes on many different levels, some of which are still not understood well enough to allow for quantitative modeling and prediction. Glycolysis in yeast is a good example: although high-quality quantitative data are available, well-established mathematical models typically only cover direct regulation of the involved enzymes by metabolite binding. The effect of various metabolites on the enzyme kinetics is summarized in carefully developed mathematical formulae. However, this approach implicitly assumes that the enzyme concentrations themselves are constant, thus neglecting other regulatory levels - e.g. transcriptional and translational regulation--involved in the regulation of enzyme activities. It is believed, however, that different experimental conditions result in different enzyme activities regulated by the above mechanisms. Detailed modeling of all regulatory levels is still out of reach since some of the necessary data - e.g. quantitative large scale enzyme concentration data sets - are lacking or rare. Nevertheless, a viable approach is to include the regulation of enzyme concentrations into an established model and to investigate whether this improves the predictive capabilities. Proteome data are usually hard to obtain, but levels of mRNA transcripts may be used instead as clues for changes in enzyme concentrations. Here we investigate whether including mRNA data into an established model of yeast glycolysis allows to predict the steady state metabolic concentrations for different experimental conditions. To this end, we modified an established ODE model for the glycolytic pathway of yeast to include changes of enzyme concentrations. Presumable changes were inferred from mRNA transcri…
species: metaid P2G
species: metaid ATP
reaction: metaid vENO
species: metaid NAD
reaction: metaid vATP
area units: 237671
reaction: metaid vPFK
species: metaid GLYout
curated: false
units def: 165554
units def: 165529
modified:
  W3 CDTF: Fri Feb 03 13:24:37 GMT 2012
units def: 165734
species: metaid ACE
species: metaid NADH
reaction: metaid vG3PDH
volume units: 290956
reaction: metaid vGLK
time units: 165554
occurs in: http://identifiers.org/taxonomy/4932
reaction: metaid vGLYCO
creator:
  ORG:
    orgname: University of Manchester
  n:
    given: Kieran
    family: Smallbone
species: metaid GLCi
reaction: metaid vPGI
species: metaid F26BP
substance units: 165529
reaction: metaid vPYK
species: metaid AMP
name: Bruck2008_Glycolysis
species: metaid ETOH
species: metaid PYR
units def: 165578
reaction: metaid vGAPDH
creator:
  ORG:
    orgname: Humboldt-Universitat zu Berlin
  n:
    given: Jozsef
    family: Bruck
compartment: metaid extracellular
parameter: 165818
length unit: 821056
species: metaid TRIO

metaid BPG
type: Species
name: 1,3-bisphosphoglycerate
boundary condition: false
in compartment: metaid cell
initial amount: NaN
has only substance units: false
initial concentration: 0.0
is: SBO:0000247
is: CHEBI:16001
constant: false
is: C00236

metaid cell
type: Compartment
is: GO:0005829
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

metaid vTCA
type: Reaction
product: 167492
is: GO:0006099
reactant: 167456
reactant: 167444
fast: false
kinetic law: 167517
product: 167480
reactant: 167468
product: 167504
name: TCA
reversible: true
is: SBO:0000176

167492
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

metaid ATP
type: Species
name: ATP
is: CHEBI:15422
has only substance units: false
in compartment: metaid cell
is: C00002
is: SBO:0000247
boundary condition: false
initial concentration: 1.6616
notes: species added by BJ
constant: false
initial amount: NaN

167456
type: SpeciesReference
stoichiometry: 4.0
species: metaid NAD

metaid NAD
type: Species
initial concentration: 1.2
is: SBO:0000247
is: C00003
in compartment: metaid cell
initial amount: NaN
is: CHEBI:15846
constant: false
name: NAD
has only substance units: false
boundary condition: false

167444
type: SpeciesReference
stoichiometry: 1.0
species: metaid ACE

metaid ACE
type: Species
name: acetaldehyde
constant: false
in compartment: metaid cell
initial concentration: 0.04
is: C00084
has only substance units: false
is: CHEBI:15343
initial amount: NaN
is: SBO:0000247
boundary condition: false

167541
type: LocalParameter
units: 165782
value: 1.0

165782
type: SBMLUnitsDef
unit: 165806
unit: 165794
name: per mM

165806
type: SBMLUnit
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE

165794
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE

167529
type: LocalParameter
units: 165734
value: 20.0

165734
type: SBMLUnitsDef
unit: 165770
unit: 165758
unit: 165746
name: per mM squared per minute

165770
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 60.0
kind: SECOND

165758
type: SBMLUnit
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kind: LITRE

165746
type: SBMLUnit
exponent: -2.0
scale: -3
multipler: 1.0
kind: MOLE

167480
type: SpeciesReference
stoichiometry: 4.0
species: metaid NADH

metaid NADH
type: Species
is: CHEBI:16908
in compartment: metaid cell
is: SBO:0000247
boundary condition: false
name: NADH
initial concentration: 0.39
initial amount: NaN
is: C00004
has only substance units: false
constant: false

167468
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

metaid ADP
type: Species
has only substance units: false
is: C00008
name: ADP
is: CHEBI:16761
is: SBO:0000247
in compartment: metaid cell
constant: false
initial amount: NaN
notes: species added by BJ
initial concentration: 1.6769
boundary condition: false

167504
type: SpeciesReference
stoichiometry: 2.0
species: metaid CO2

metaid CO2
type: Species
in compartment: metaid cell
constant: true
is: CHEBI:16526
initial amount: NaN
initial concentration: 1.0
is: C00011
has only substance units: false
is: SBO:0000247
name: CO2
boundary condition: true

metaid PEP
type: Species
constant: false
boundary condition: false
name: phosphoenolpyruvate
has only substance units: false
is: C00074
in compartment: metaid cell
initial amount: NaN
initial concentration: 0.1
is: SBO:0000247
is: CHEBI:18021

metaid F16P
type: Species
in compartment: metaid cell
has only substance units: false
initial concentration: 0.1
constant: false
initial amount: NaN
name: fructose 1,6-bisphosphate
is: SBO:0000247
is: C05378
boundary condition: false
is: CHEBI:28013

metaid GLY
type: Species
constant: false
boundary condition: false
is: C00116
is: CHEBI:17754
has only substance units: false
name: glycerol
initial concentration: 0.15
initial amount: NaN
is: SBO:0000247
in compartment: metaid cell

metaid vPGK
type: Reaction
reversible: true
is version of: http://identifiers.org/ec-code/2.7.2.3
product: 166948
reactant: 166912
is version of: GO:0004618
product: 166936
fast: false
kinetic law: 166960
is: SBO:0000176
name: 3-phosphoglycerate kinase
reactant: 166924
is: R01512

166948
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

166912
type: SpeciesReference
stoichiometry: 1.0
species: metaid BPG

166936
type: SpeciesReference
stoichiometry: 1.0
species: metaid P3G

metaid P3G
type: Species
is: C00197
name: 3-phosphoglycerate
initial amount: NaN
is: SBO:0000247
constant: false
in compartment: metaid cell
initial concentration: 0.1
boundary condition: false
has only substance units: false
is: CHEBI:17794

167033
type: LocalParameter
units: 165578
value: 0.003

165578
type: SBMLUnitsDef
unit: 165602
unit: 165590
name: mM

165602
type: SBMLUnit
exponent: -1.0
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multipler: 1.0
kind: LITRE

165590
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

167021
type: LocalParameter
units: 165578
value: 0.2

167009
type: LocalParameter
units: 165578
value: 0.53

166997
type: LocalParameter
units: 165578
value: 0.3

166985
type: LocalParameter
units: dimensionless
value: 3200.0

166973
type: LocalParameter
units: 165614
value: 1306.45

165614
type: SBMLUnitsDef
unit: 165650
unit: 165638
unit: 165626
name: mM per minute

165650
type: SBMLUnit
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kind: SECOND

165638
type: SBMLUnit
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scale: 0
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kind: LITRE

165626
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

166924
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

165686
type: SBMLUnitsDef
unit: 165722
unit: 165710
unit: 165698
name: per mM per minute

165722
type: SBMLUnit
exponent: -1.0
scale: 1
multipler: 60.0
kind: SECOND

165710
type: SBMLUnit
exponent: 1.0
scale: 1
multipler: 1.0
kind: LITRE

165698
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE

metaid vALD
type: Reaction
is: SBO:0000176
product: 166532
name: fructosebisphosphate aldolase
reversible: true
is version of: GO:0004332
kinetic law: 166544
is version of: http://identifiers.org/ec-code/4.1.2.13
is: R01068
reactant: 166520
fast: false

166532
type: SpeciesReference
stoichiometry: 2.0
species: metaid TRIO

metaid TRIO
type: Species
name: triose-phosphate
has part: C00111
initial amount: NaN
boundary condition: false
has only substance units: false
constant: false
has part: C00118
in compartment: metaid cell
has part: CHEBI:29052
has part: CHEBI:16108
initial concentration: 5.17

166617
type: LocalParameter
units: 165578
value: 10.0

166605
type: LocalParameter
units: 165578
value: 2.0

166593
type: LocalParameter
units: 165578
value: 2.4

166581
type: LocalParameter
units: 165578
value: 0.3

166569
type: LocalParameter
units: 165578
value: 0.069

166557
type: LocalParameter
units: 165614
value: 322.258

166520
type: SpeciesReference
stoichiometry: 1.0
species: metaid F16P

165662
type: SBMLUnitsDef
unit: 165674
name: permin

165674
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

metaid vPGM
type: Reaction
fast: false
kinetic law: 167069
is version of: http://identifiers.org/ec-code/5.4.2.1
is version of: GO:0004619
name: phosphoglyceromutase
is: R01518
reversible: true
is: SBO:0000176
product: 167057
reactant: 167045

167117
type: LocalParameter
units: 165578
value: 0.08

167105
type: LocalParameter
units: dimensionless
value: 0.19

167093
type: LocalParameter
units: 165578
value: 1.2

167081
type: LocalParameter
units: 165614
value: 2525.81

167057
type: SpeciesReference
stoichiometry: 1.0
species: metaid P2G

metaid P2G
type: Species
is: CHEBI:17835
initial concentration: 0.1
has only substance units: false
is: C00631
initial amount: NaN
name: 2-phosphoglycerate
is: SBO:0000247
constant: false
boundary condition: false
in compartment: metaid cell

167045
type: SpeciesReference
stoichiometry: 1.0
species: metaid P3G

metaid F6P
type: Species
name: fructose 6-phosphate
has only substance units: false
is: C05345
constant: false
is: SBO:0000247
initial concentration: 0.28
boundary condition: false
in compartment: metaid cell
initial amount: NaN
is: CHEBI:16084

metaid vADH
type: Reaction
is: R00754
reactant: 167553
reversible: true
is: SBO:0000176
product: 167589
is version of: GO:0004022
is version of: http://identifiers.org/ec-code/1.1.1.1
fast: false
product: 167577
reactant: 167565
name: alcohol dehydrogenase
kinetic law: 167601

167553
type: SpeciesReference
stoichiometry: 1.0
species: metaid ACE

167589
type: SpeciesReference
stoichiometry: 1.0
species: metaid NAD

167577
type: SpeciesReference
stoichiometry: 1.0
species: metaid ETOH

metaid ETOH
type: Species
initial concentration: 50.0
boundary condition: true
in compartment: metaid cell
constant: true
initial amount: NaN
has only substance units: false
name: ethanol
is: SBO:0000247
is: CHEBI:16236
is: C00469

167565
type: SpeciesReference
stoichiometry: 1.0
species: metaid NADH

167698
type: LocalParameter
units: 165578
value: 1.11

167637
type: LocalParameter
units: 165578
value: 17.0

167686
type: LocalParameter
units: 165578
value: 0.031

167674
type: LocalParameter
units: 165578
value: 0.11

167625
type: LocalParameter
units: 165578
value: 0.92

167661
type: LocalParameter
units: 165578
value: 0.17

167722
type: LocalParameter
units: 165578
value: 90.0

167613
type: LocalParameter
units: 165614
value: 810.0

167710
type: LocalParameter
units: 165578
value: 1.1

167649
type: LocalParameter
units: dimensionless
value: 6.9E-5

metaid vPDC
type: Reaction
kinetic law: 167383
product: 167371
fast: false
is: SBO:0000176
name: pyruvate decarboxylase
reactant: 167347
is: R00636
is version of: http://identifiers.org/ec-code/4.1.1.1
notes: Kinetics by BJ: to make the step PDC reversible a negative term was added to the original irreversible hill kinetics of [Teusink] with the new constant KmPDCACE
reversible: true
is version of: GO:0004737
product: 167359

167431
type: LocalParameter
units: 165578
value: 5.0

167419
type: LocalParameter
units: 165578
value: 4.33

167407
type: LocalParameter
units: dimensionless
value: 1.9

167395
type: LocalParameter
units: 165614
value: 174.194

167371
type: SpeciesReference
stoichiometry: 1.0
species: metaid CO2

167347
type: SpeciesReference
stoichiometry: 1.0
species: metaid PYR

metaid PYR
type: Species
in compartment: metaid cell
initial concentration: 3.36
constant: false
is: C00022
is: CHEBI:15361
is: SBO:0000247
boundary condition: false
has only substance units: false
name: pyruvate
initial amount: NaN

167359
type: SpeciesReference
stoichiometry: 1.0
species: metaid ACE

metaid vFBP
type: Reaction
product: 167942
fast: false
reactant: 167930
is: GO:0042132
kinetic law: 167954
is: SBO:0000176
name: fructose 1,6-bisphosphatase
notes: added by BJ: to make the step F6P->F16BP reversible in Glycolysis
reversible: false
is: http://identifiers.org/ec-code/3.1.3.11

167942
type: SpeciesReference
stoichiometry: 1.0
species: metaid F6P

167930
type: SpeciesReference
stoichiometry: 1.0
species: metaid F16P

167966
type: LocalParameter
units: 165662
value: 1000.0

metaid GLYtrs
type: Reaction
reversible: false
reactant: 167869
kinetic law: 167894
notes: added by BJ: Glycerol transport reaction to compare with Glycerol_outside concentration which is measured in [Wiebe]
fast: false
name: glycerol efflux
product: 167881
is: SBO:0000185
is version of: GO:0015793

167869
type: SpeciesReference
stoichiometry: 1.0
species: metaid GLY

167918
type: LocalParameter
units: dimensionless
value: 2.0

167906
type: LocalParameter
units: 165662
value: 1000.0

167881
type: SpeciesReference
stoichiometry: 1.0
species: metaid GLYout

metaid GLYout
type: Species
in compartment: metaid extracellular
boundary condition: true
is: SBO:0000247
has only substance units: false
constant: true
initial concentration: 8.67
name: glycerol
is: CHEBI:17754
is: C00116
initial amount: NaN

metaid extracellular
type: Compartment
is: GO:0005576
constant: true
size: 1.0
spatial dimensions: 3.0
name: extracellular

metaid vGLT
type: Reaction
kinetic law: 165854
product: 165842
reactant: 165830
is version of: GO:0015758
is: SBO:0000185
fast: false
reversible: true
name: glucose transport

165903
type: LocalParameter
units: 165578
value: 1.1918

165891
type: LocalParameter
units: 165578
value: 1.1918

165879
type: LocalParameter
units: dimensionless
value: 1.0

165866
type: LocalParameter
units: 165614
value: 97.264

165842
type: SpeciesReference
stoichiometry: 1.0
species: metaid GLCi

metaid GLCi
type: Species
initial concentration: 0.087
is: C00031
is: SBO:0000247
initial amount: NaN
name: glucose
constant: false
has only substance units: false
is: CHEBI:4167
in compartment: metaid cell
boundary condition: false

165830
type: SpeciesReference
stoichiometry: 1.0
species: metaid GLCo

metaid GLCo
type: Species
initial amount: NaN
is: C00031
name: glucose
constant: true
is: CHEBI:4167
boundary condition: true
is: SBO:0000247
has only substance units: false
in compartment: metaid extracellular
initial concentration: 50.0

metaid vAdKin
type: Reaction
product: 166216
reactant: 166192
is version of: GO:0004017
is: SBO:0000176
fast: false
is version of: http://identifiers.org/ec-code/2.7.4.3
is: R00127
reactant: 166204
kinetic law: 166228
reversible: true
name: adenylate kinase

166216
type: SpeciesReference
stoichiometry: 2.0
species: metaid ADP

166192
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

166204
type: SpeciesReference
stoichiometry: 1.0
species: metaid AMP

metaid AMP
type: Species
is: C00020
is: SBO:0000247
boundary condition: false
name: AMP
initial amount: NaN
initial concentration: 0.76156
has only substance units: false
in compartment: metaid cell
notes: species added by BJ
constant: false
is: CHEBI:16027

166252
type: LocalParameter
units: dimensionless
value: 0.45

166240
type: LocalParameter
units: 165686
value: 1.0

metaid G6P
type: Species
is: CHEBI:17665
name: glucose 6-phosphate
has only substance units: false
initial amount: NaN
initial concentration: 1.39
boundary condition: false
is: SBO:0000247
in compartment: metaid cell
is: C00668
constant: false

metaid vRESP
type: Reaction
name: respiration
is: GO:0045333
reversible: false
kinetic law: 167832
reactant: 167783
notes: added by BJ: respiration(oxidative phosphorylation) - rate will be multiplied with relativ Oxygen level
reactant: 167795
is: SBO:0000176
product: 167807
fast: false
product: 167819

167856
type: LocalParameter
units: dimensionless
value: 1.0

167844
type: LocalParameter
units: 165686
value: 66.6666666666667

167783
type: SpeciesReference
stoichiometry: 1.0
species: metaid NADH

167795
type: SpeciesReference
stoichiometry: 2.5
species: metaid ADP

167807
type: SpeciesReference
stoichiometry: 1.0
species: metaid NAD

167819
type: SpeciesReference
stoichiometry: 2.5
species: metaid ATP

metaid vENO
type: Reaction
reactant: 167129
product: 167141
is version of: http://identifiers.org/ec-code/4.2.1.11
is: SBO:0000176
reversible: true
name: enolase
is: R00658
fast: false
is version of: GO:0004634
kinetic law: 167153

167129
type: SpeciesReference
stoichiometry: 1.0
species: metaid P2G

167141
type: SpeciesReference
stoichiometry: 1.0
species: metaid PEP

167201
type: LocalParameter
units: 165578
value: 0.5

167189
type: LocalParameter
units: dimensionless
value: 6.7

167177
type: LocalParameter
units: 165578
value: 0.04

167165
type: LocalParameter
units: 165614
value: 365.806

metaid vATP
type: Reaction
kinetic law: 167759
product: 167746
reactant: 167734
is version of: GO:0016887
is: SBO:0000176
fast: false
reversible: true
name: ATPase

167771
type: LocalParameter
units: 165662
value: 39.5

167746
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

167734
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

metaid vPFK
type: Reaction
reactant: 166276
is: SBO:0000176
is: R00756
is version of: GO:0003872
notes: ReactionRate typed again by BJ,2008 based on paper eq.A9-12 (the one contained in the Teusink-file was suspciously complex, eg. conained[ADP])
is version of: http://identifiers.org/ec-code/2.7.1.11
fast: false
modifier: 166325
kinetic law: 166337
product: 166288
reactant: 166264
product: 166301
reversible: true
modifier: 166313
name: phosphofructokinase

166276
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

metaid F26BP
type: Species
is: C00665
is: SBO:0000247
has only substance units: false
initial amount: NaN
name: fructose 2,6-bisphosphate
in compartment: metaid cell
constant: true
is: CHEBI:28602
boundary condition: true
initial concentration: 0.02

166373
type: LocalParameter
units: 165578
value: 0.1

166349
type: LocalParameter
units: dimensionless
value: 5.12

166398
type: LocalParameter
units: dimensionless
value: 0.66

166410
type: LocalParameter
units: dimensionless
value: 0.0174

166361
type: LocalParameter
units: 165614
value: 182.903

166446
type: LocalParameter
units: 165578
value: 0.111

166483
type: LocalParameter
units: dimensionless
value: 100.0

166386
type: LocalParameter
units: 165578
value: 0.71

166458
type: LocalParameter
units: dimensionless
value: 0.0845

166495
type: LocalParameter
units: 165578
value: 0.65

166422
type: LocalParameter
units: 165578
value: 6.82E-4

166434
type: LocalParameter
units: dimensionless
value: 0.397

166471
type: LocalParameter
units: 165578
value: 0.0995

166508
type: LocalParameter
units: dimensionless
value: 3.0

166288
type: SpeciesReference
stoichiometry: 1.0
species: metaid F16P

166264
type: SpeciesReference
stoichiometry: 1.0
species: metaid F6P

166301
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

165554
type: SBMLUnitsDef
unit: 165566
name: minute

165566
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

165529
type: SBMLUnitsDef
unit: 165541
name: millimole

165541
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

metaid vG3PDH
type: Reaction
product: 166665
reversible: true
fast: false
product: 166653
name: glycerol 3-phosphate dehydrogenase
is: http://identifiers.org/ec-code/1.1.1.94
reactant: 166641
is: SBO:0000176
reactant: 166629
kinetic law: 166678
is: R00842

166665
type: SpeciesReference
stoichiometry: 1.0
species: metaid GLY

166653
type: SpeciesReference
stoichiometry: 1.0
species: metaid NAD

166641
type: SpeciesReference
stoichiometry: 1.0
species: metaid TRIO

166629
type: SpeciesReference
stoichiometry: 1.0
species: metaid NADH

166756
type: LocalParameter
units: 165578
value: 1.0

166743
type: LocalParameter
units: 165578
value: 0.93

166730
type: LocalParameter
units: 165578
value: 0.023

166717
type: LocalParameter
units: 165578
value: 0.4

166704
type: LocalParameter
units: dimensionless
value: 4300.0

166691
type: LocalParameter
units: 165614
value: 70.15

metaid vGLK
type: Reaction
reactant: 165915
is: R02848
product: 165939
is version of: GO:0004396
is version of: http://identifiers.org/ec-code/2.7.1.1
fast: false
kinetic law: 165963
name: hexokinase
reversible: true
product: 165951
is: SBO:0000176
reactant: 165927

165915
type: SpeciesReference
stoichiometry: 1.0
species: metaid GLCi

165939
type: SpeciesReference
stoichiometry: 1.0
species: metaid G6P

166035
type: LocalParameter
units: 165578
value: 0.23

166023
type: LocalParameter
units: 165578
value: 30.0

166011
type: LocalParameter
units: 165578
value: 0.08

165999
type: LocalParameter
units: 165578
value: 0.15

165987
type: LocalParameter
units: dimensionless
value: 3800.0

165975
type: LocalParameter
units: 165614
value: 226.452

165951
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

165927
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

metaid vGLYCO
type: Reaction
kinetic law: 166168
has part: GO:0005978
has part: GO:0005992
reversible: true
is: SBO:0000176
name: G6P consumption
fast: false
reactant: 166144
reactant: 166132
product: 166156

166180
type: LocalParameter
units: 165686
value: 6.0

166144
type: SpeciesReference
stoichiometry: 1.0
species: metaid G6P

166132
type: SpeciesReference
notes: modified by BJ was P in Teusink
stoichiometry: 1.0
species: metaid ATP

166156
type: SpeciesReference
notes: product added by BJ
stoichiometry: 1.0
species: metaid ADP

metaid vPGI
type: Reaction
reactant: 166047
reversible: true
name: phosphoglucose isomerase
is version of: http://identifiers.org/ec-code/5.3.1.9
product: 166059
is: SBO:0000176
fast: false
kinetic law: 166072
is: R00771
is version of: GO:0004347

166047
type: SpeciesReference
stoichiometry: 1.0
species: metaid G6P

166059
type: SpeciesReference
stoichiometry: 1.0
species: metaid F6P

166120
type: LocalParameter
units: 165578
value: 0.3

166108
type: LocalParameter
units: dimensionless
value: 0.314

166096
type: LocalParameter
units: 165578
value: 1.4

166084
type: LocalParameter
units: 165614
value: 339.677

metaid vPYK
type: Reaction
is version of: GO:0004743
is: SBO:0000176
fast: false
reactant: 167225
product: 167250
reversible: true
kinetic law: 167262
reactant: 167213
product: 167238
is: R00200
name: pyruvate kinase
is version of: http://identifiers.org/ec-code/2.7.1.40

167225
type: SpeciesReference
stoichiometry: 1.0
species: metaid ADP

167250
type: SpeciesReference
stoichiometry: 1.0
species: metaid ATP

167335
type: LocalParameter
units: 165578
value: 1.5

167323
type: LocalParameter
units: 165578
value: 21.0

167310
type: LocalParameter
units: dimensionless
value: 6500.0

167298
type: LocalParameter
units: 165578
value: 0.53

167286
type: LocalParameter
units: 165578
value: 0.14

167274
type: LocalParameter
units: 165614
value: 1088.71

167213
type: SpeciesReference
stoichiometry: 1.0
species: metaid PEP

167238
type: SpeciesReference
stoichiometry: 1.0
species: metaid PYR

metaid vGAPDH
type: Reaction
is version of: http://identifiers.org/ec-code/1.2.1.12
is: R01061
is: SBO:0000176
is version of: GO:0004365
product: 166804
product: 166792
reversible: true
reactant: 166780
kinetic law: 166816
name: glyceraldehyde phosphate dehydrogenase
reactant: 166768
notes: introduce new constant VmGAPDHall "overall Vm" (original has forward and reverse separately) only to have a constant to be multiplied when modelling genetic regulation
fast: false

166804
type: SpeciesReference
stoichiometry: 1.0
species: metaid BPG

166792
type: SpeciesReference
stoichiometry: 1.0
species: metaid NADH

166780
type: SpeciesReference
stoichiometry: 1.0
species: metaid TRIO

166900
type: LocalParameter
units: dimensionless
value: 1.0

166888
type: LocalParameter
units: 165578
value: 0.09

166876
type: LocalParameter
units: 165578
value: 0.21

166864
type: LocalParameter
units: 165614
value: 1184.52

166852
type: LocalParameter
units: 165578
value: 0.06

166840
type: LocalParameter
units: 165578
value: 0.0098

166828
type: LocalParameter
units: 165614
value: 6549.68

166768
type: SpeciesReference
stoichiometry: 1.0
species: metaid NAD

165818
type: Parameter
constant: true
units: dimensionless
value: 0.045