MODEL1009150002
type: SBMLModel
reaction: 647689
reaction: 647177
reaction: 648029
species: 646561
species: 646043
reaction: 647342
species: 645013
reaction: 649720
reaction: 647695
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species: 645878
reaction: 648455
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reaction: 649687
reaction: 650466
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species: 645938
reaction: 647759
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reaction: 648347
reaction: 650495
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reaction: 650020
reaction: 649579
reaction: 647278
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species: 646484
reaction: 648514
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reaction: 648002
reaction: 649792
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reaction: 648049
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reaction: 648098
reaction: 649093
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species: 644668
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reaction: 649843
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reaction: 647240
reaction: 649909
species: 646241
reaction: 648262
reaction: 650703
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reaction: 648863
reaction: 648929
reaction: 650839
species: 644918
species: 644815
reaction: 648152
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reaction: 647918
reaction: 650874
reaction: 648733
reaction: 650486
reaction: 650546
species: 645749
reaction: 648623
reaction: 648338
species: 645377
species: 645325
reaction: 649006
species: 647112
reaction: 647554
reaction: 649645
reaction: 648344
species: 645412
reaction: 648073

647689
type: Reaction
product: 055809
kinetic law: 055822
notes: GENE_ASSOCIATION: (5832.1) GENE_LIST: 5832.1 SUBSYSTEM: Urea cycle/amino group metabolism
fast: false
product: 055797
reactant: 055785
reversible: false
reactant: 055773
name: glutamate 5-kinase (m)

055809
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species: 645608

645608
type: Species
notes: FORMULA: C5H8NO7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Glutamate 5-phosphate

644621
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Mitochondrion

654260
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value: 500.0

032995
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scale: 0
multipler: 3600.0
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032983
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033019
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654254
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value: 0.0

055797
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species: 644977

644977
type: Species
notes: FORMULA: C10H12N5O10P2
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: ADP

055785
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species: 645616

645616
type: Species
notes: FORMULA: C5H8NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Glutamate

055773
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species: 645091

645091
type: Species
notes: FORMULA: C10H12N5O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: ATP

647177
type: Reaction
kinetic law: 035362
product: 035350
reactant: 035338
fast: false
reversible: true
name: Taurocholic acid exchange

651209
type: LocalParameter
units: 032971
value: 0.0

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type: LocalParameter
value: 0.0

651203
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units: 033007
value: 1000.0

651202
type: LocalParameter
units: 033007
value: -1000.0

035350
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species: 646760

646760
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 34dhoxpeg_b

644618
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Extracellular

035338
type: SpeciesReference
stoichiometry: 1.0
species: 646412

646412
type: Species
notes: FORMULA: C26H45NO7S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: taurocholic acid

648029
type: Reaction
notes: GENE_ASSOCIATION: (231.1) GENE_LIST: 231.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
reversible: false
reactant: 069397
product: 069433
product: 069457
reactant: 069421
kinetic law: 069469
product: 069445
name: Aldose reductase
reactant: 069409
fast: false

069397
type: SpeciesReference
stoichiometry: 1.0
species: 645700

645700
type: Species
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: H2O

644617
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Cytoplasm

069433
type: SpeciesReference
stoichiometry: 2.0
species: 645712

645712
type: Species
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: H+

069457
type: SpeciesReference
stoichiometry: 1.0
species: 646280

646280
type: Species
notes: FORMULA: C3H3O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Pyruvate

069421
type: SpeciesReference
stoichiometry: 1.0
species: 646010

646010
type: Species
notes: FORMULA: C21H25N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinamide adenine dinucleotide phosphate

655896
type: LocalParameter
units: 032971
value: 500.0

655894
type: LocalParameter
value: 0.0

655892
type: LocalParameter
units: 033007
value: 1000.0

655890
type: LocalParameter
units: 033007
value: 0.0

069445
type: SpeciesReference
stoichiometry: 1.0
species: 646018

646018
type: Species
notes: FORMULA: C21H26N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinamide adenine dinucleotide phosphate - reduced

069409
type: SpeciesReference
stoichiometry: 1.0
species: 645985

645985
type: Species
notes: FORMULA: C3H4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Methylglyoxal

646561
type: Species
notes: FORMULA: C5H4N4O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Urate

646043
type: Species
notes: FORMULA: NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Nitric oxide

647342
type: Reaction
kinetic law: 042114
product: 042102
reactant: 042090
fast: false
reversible: true
name: lysophosphatidylcholine (homo sapiens) exchange

652263
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units: 032971
value: 0.0

652260
type: LocalParameter
value: 0.0

652257
type: LocalParameter
units: 033007
value: 1000.0

652254
type: LocalParameter
units: 033007
value: -1000.0

042102
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stoichiometry: 1.0
species: 646780

646780
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 5thf_b

042090
type: SpeciesReference
stoichiometry: 1.0
species: 645911

645911
type: Species
notes: FORMULA: C8H19NO5PFULLRCO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: lysophosphatidylcholine (homo sapiens)

645013
type: Species
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: beta-Alanine

649720
type: Reaction
kinetic law: 113903
product: 113891
reactant: 113879
reactant: 113867
notes: GENE_ASSOCIATION: (2739.1) GENE_LIST: 2739.1 SUBSYSTEM: Pyruvate Metabolism
fast: false
reversible: false
name: lactoylglutathione lyase

660005
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units: 032971
value: 500.0

660003
type: LocalParameter
value: 0.0

660002
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units: 033007
value: 1000.0

660000
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units: 033007
value: 0.0

113891
type: SpeciesReference
stoichiometry: 1.0
species: 645866

645866
type: Species
notes: FORMULA: C13H20N3O8S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (R)-S-Lactoylglutathione

113879
type: SpeciesReference
stoichiometry: 1.0
species: 645985

113867
type: SpeciesReference
stoichiometry: 1.0
species: 645670

645670
type: Species
notes: FORMULA: C10H16N3O6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Reduced glutathione

647695
type: Reaction
kinetic law: 056125
product: 056113
reactant: 056100
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: bile acid intracellular transport

654288
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units: 032971
value: 0.0

654286
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value: 0.0

654284
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units: 033007
value: 1000.0

654282
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units: 033007
value: -1000.0

056113
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stoichiometry: 1.0
species: 646420

646420
type: Species
notes: FORMULA: C26H45NO6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: taurochenodeoxycholate

056100
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species: 646423

646423
type: Species
notes: FORMULA: C26H45NO6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: taurochenodeoxycholate

644626
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Peroxisome

646801
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: adprib_b

645878
type: Species
notes: FORMULA: C25H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Linoelaidyl carnitine

648455
type: Reaction
kinetic law: 083962
product: 083950
reactant: 083938
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: deoxyuridine transport in nucleus

657433
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units: 032971
value: 0.0

657432
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value: 0.0

657431
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units: 033007
value: 1000.0

657430
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units: 033007
value: -1000.0

083950
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stoichiometry: 1.0
species: 645445

645445
type: Species
notes: FORMULA: C9H12N2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: Deoxyuridine

644623
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Nucleus

083938
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stoichiometry: 1.0
species: 645442

645442
type: Species
notes: FORMULA: C9H12N2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Deoxyuridine

645100
type: Species
notes: FORMULA: C3H8NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: beta-Aminopropion aldehyde

649687
type: Reaction
kinetic law: 113229
product: 113217
reactant: 113205
fast: false
reversible: true
name: Acetone exchange

659945
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units: 032971
value: 0.0

659943
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value: 0.0

659942
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units: 033007
value: 1000.0

659940
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units: 033007
value: -1000.0

113217
type: SpeciesReference
stoichiometry: 1.0
species: 647014

647014
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: pheacgln_b

113205
type: SpeciesReference
stoichiometry: 1.0
species: 644948

644948
type: Species
notes: FORMULA: C3H6O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Acetone

650466
type: Reaction
kinetic law: 129895
product: 129883
reactant: 129871
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport

661558
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units: 032971
value: 0.0

661556
type: LocalParameter
value: 0.0

661555
type: LocalParameter
units: 033007
value: 1000.0

661553
type: LocalParameter
units: 033007
value: -1000.0

129883
type: SpeciesReference
stoichiometry: 1.0
species: 645203

645203
type: Species
notes: FORMULA: C43H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: clupanodonyl CoA

129871
type: SpeciesReference
stoichiometry: 1.0
species: 645202

645202
type: Species
notes: FORMULA: C43H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: clupanodonyl CoA

646642
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 7-alpha,25-Dihydroxycholesterol

644624
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Endoplasmic_reticulum

645938
type: Species
notes: FORMULA: CH4O1
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Methanol

647759
type: Reaction
kinetic law: 058812
product: 058800
reactant: 058787
notes: GENE_ASSOCIATION: (1638.1) GENE_LIST: 1638.1 SUBSYSTEM: Tyrosine metabolism
fast: false
reversible: true
name: Dopachrome tautomerase

654589
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units: 032971
value: 0.0

654587
type: LocalParameter
value: 0.0

654585
type: LocalParameter
units: 033007
value: 1000.0

654583
type: LocalParameter
units: 033007
value: -1000.0

058800
type: SpeciesReference
stoichiometry: 1.0
species: 644801

644801
type: Species
notes: FORMULA: C9H6NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5,6-Dihydroxyindole-2-carboxylate

058787
type: SpeciesReference
stoichiometry: 1.0
species: 644873

644873
type: Species
notes: FORMULA: C9H6NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Dopachrome

645590
type: Species
notes: FORMULA: C6H8O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-glucurono-6,3-lactone

648347
type: Reaction
kinetic law: 079721
product: 079709
reactant: 079697
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: deoxyadenosine transport via diffusion

657017
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units: 032971
value: 0.0

657016
type: LocalParameter
value: 0.0

657015
type: LocalParameter
units: 033007
value: 1000.0

657013
type: LocalParameter
units: 033007
value: -1000.0

079709
type: SpeciesReference
stoichiometry: 1.0
species: 645274

645274
type: Species
notes: FORMULA: C10H13N5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Deoxyadenosine

079697
type: SpeciesReference
stoichiometry: 1.0
species: 645275

645275
type: Species
notes: FORMULA: C10H13N5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Deoxyadenosine

650495
type: Reaction
reactant: 130632
fast: false
product: 130656
reactant: 130644
notes: GENE_ASSOCIATION: (126129.1) or (1375.3) or (1375.1) or (1375.2) or (1374.1) or (1375.4) GENE_LIST: 126129.1 1374.1 1375.1 1375.2 1375.3 1375.4 SUBSYSTEM: Carnitine shuttle
product: 130668
kinetic law: 130680
name: carnitine O-palmitoyltransferase
reversible: false

130632
type: SpeciesReference
stoichiometry: 1.0
species: 645244

645244
type: Species
notes: FORMULA: C7H15NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Carnitine

130656
type: SpeciesReference
stoichiometry: 1.0
species: 645223

645223
type: Species
notes: FORMULA: C21H32N7O16P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Coenzyme A

130644
type: SpeciesReference
stoichiometry: 1.0
species: 645749

645749
type: Species
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: trans-Hexadec-2-enoyl-CoA

130668
type: SpeciesReference
stoichiometry: 1.0
species: 645754

645754
type: Species
notes: FORMULA: C23H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: trans-Hexadec-2-enoyl carnitine

661640
type: LocalParameter
units: 032971
value: 500.0

661639
type: LocalParameter
value: 0.0

661637
type: LocalParameter
units: 033007
value: 1000.0

661636
type: LocalParameter
units: 033007
value: 0.0

645935
type: Species
notes: FORMULA: C9H6NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Melanin

650020
type: Reaction
kinetic law: 119670
product: 119658
reactant: 119645
fast: false
reversible: true
name: Hydrogen peroxide exchange

660554
type: LocalParameter
units: 032971
value: 0.0

660552
type: LocalParameter
value: 0.0

660551
type: LocalParameter
units: 033007
value: 1000.0

660549
type: LocalParameter
units: 033007
value: -1000.0

119658
type: SpeciesReference
stoichiometry: 1.0
species: 647041

647041
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: sl_DASH_L_b

119645
type: SpeciesReference
stoichiometry: 1.0
species: 645694

645694
type: Species
notes: FORMULA: H2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Hydrogen peroxide

649579
type: Reaction
reactant: 111164
kinetic law: 111200
reactant: 111152
reversible: false
product: 111188
notes: GENE_ASSOCIATION: (6647.1) GENE_LIST: 6647.1 SUBSYSTEM: ROS Detoxification
name: superoxide dismutase
fast: false
product: 111176

111164
type: SpeciesReference
stoichiometry: 2.0
species: 646066

646066
type: Species
notes: FORMULA: O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Superoxide anion

659751
type: LocalParameter
units: 032971
value: 500.0

659749
type: LocalParameter
value: 0.0

659748
type: LocalParameter
units: 033007
value: 1000.0

659746
type: LocalParameter
units: 033007
value: 0.0

111152
type: SpeciesReference
stoichiometry: 2.0
species: 645712

111188
type: SpeciesReference
stoichiometry: 1.0
species: 646060

646060
type: Species
notes: FORMULA: O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: O2

111176
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stoichiometry: 1.0
species: 645692

645692
type: Species
notes: FORMULA: H2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hydrogen peroxide

647278
type: Reaction
fast: false
reactant: 039620
product: 039644
product: 039693
reactant: 039632
reactant: 039596
product: 039681
reversible: false
kinetic law: 039705
product: 039656
name: Beta oxidation of long chain fatty acid
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
reactant: 039608
product: 039669
reactant: 039584

039620
type: SpeciesReference
stoichiometry: 1.0
species: 646064

646064
type: Species
notes: FORMULA: O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: O2

039644
type: SpeciesReference
stoichiometry: 1.0
species: 644944

644944
type: Species
notes: FORMULA: C23H34N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Acetyl-CoA

039693
type: SpeciesReference
stoichiometry: 1.0
species: 646009

646009
type: Species
notes: FORMULA: C21H27N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Nicotinamide adenine dinucleotide - reduced

039632
type: SpeciesReference
stoichiometry: 1.0
species: 646444

646444
type: Species
notes: FORMULA: C45H68N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: tetracosapentaenoyl coenzyme A, n-6

039596
type: SpeciesReference
stoichiometry: 1.0
species: 645709

645709
type: Species
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: H2O

039681
type: SpeciesReference
stoichiometry: 1.0
species: 645721

645721
type: Species
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: H+

651845
type: LocalParameter
units: 032971
value: 500.0

651842
type: LocalParameter
value: 0.0

651839
type: LocalParameter
units: 033007
value: 1000.0

651838
type: LocalParameter
units: 033007
value: 0.0

039656
type: SpeciesReference
stoichiometry: 1.0
species: 645310

645310
type: Species
notes: FORMULA: C43H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

039608
type: SpeciesReference
stoichiometry: 1.0
species: 646003

646003
type: Species
notes: FORMULA: C21H26N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Nicotinamide adenine dinucleotide

039669
type: SpeciesReference
stoichiometry: 1.0
species: 645698

645698
type: Species
notes: FORMULA: H2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Hydrogen peroxide

039584
type: SpeciesReference
stoichiometry: 1.0
species: 645227

645227
type: Species
notes: FORMULA: C21H32N7O16P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Coenzyme A

644656
type: Species
notes: FORMULA: C3H12N2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1,3-Diaminopropane

645214
type: Species
notes: FORMULA: CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: CO2

650868
type: Reaction
kinetic law: 142212
product: 142199
reactant: 142187
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: false
name: retinoic acid transport in ER (13-cis)

662689
type: LocalParameter
units: 032971
value: 500.0

662687
type: LocalParameter
value: 0.0

662685
type: LocalParameter
units: 033007
value: 1000.0

662684
type: LocalParameter
units: 033007
value: 0.0

142199
type: SpeciesReference
stoichiometry: 1.0
species: 644650

644650
type: Species
notes: FORMULA: C20H27O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 13-cis-retinoate

142187
type: SpeciesReference
stoichiometry: 1.0
species: 644648

644648
type: Species
notes: FORMULA: C20H27O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 13-cis-retinoate

646397
type: Species
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: triacylglycerol (homo sapiens)

646879
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ebastineoh_b

646484
type: Species
notes: FORMULA: C5H6N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Thymine

648514
type: Reaction
product: 086204
reversible: true
notes: GENE_ASSOCIATION: (2592.1) or (2592.3) or (2592.2) GENE_LIST: 2592.1 2592.2 2592.3 SUBSYSTEM: Galactose metabolism
name: UDPglucose--hexose-1-phosphate uridylyltransferase
kinetic law: 086216
reactant: 086180
fast: false
reactant: 086168
product: 086192

086204
type: SpeciesReference
stoichiometry: 1.0
species: 646544

646544
type: Species
notes: FORMULA: C15H22N2O17P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDPgalactose

657588
type: LocalParameter
units: 032971
value: 0.0

657587
type: LocalParameter
value: 0.0

657586
type: LocalParameter
units: 033007
value: 1000.0

657585
type: LocalParameter
units: 033007
value: -1000.0

086180
type: SpeciesReference
stoichiometry: 1.0
species: 646541

646541
type: Species
notes: FORMULA: C15H22N2O17P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDPglucose

086168
type: SpeciesReference
stoichiometry: 1.0
species: 645566

645566
type: Species
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: alpha-D-Galactose 1-phosphate

086192
type: SpeciesReference
stoichiometry: 1.0
species: 645559

645559
type: Species
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Glucose 1-phosphate

646609
type: Species
notes: FORMULA: C27H46O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 27-Hydroxycholesterol

648002
type: Reaction
name: tetrahydrofolate transport via anion exchange
product: 068301
reactant: 068289
kinetic law: 068325
product: 068313
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) GENE_LIST: 6573.1 6573.2 SUBSYSTEM: Transport, Extracellular
reversible: true
reactant: 068277
fast: false

068301
type: SpeciesReference
stoichiometry: 1.0
species: 646100

646100
type: Species
notes: FORMULA: HO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hydroxide ion

068289
type: SpeciesReference
stoichiometry: 1.0
species: 646462

646462
type: Species
notes: FORMULA: C19H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 5,6,7,8-Tetrahydrofolate

655776
type: LocalParameter
units: 032971
value: 0.0

655774
type: LocalParameter
value: 0.0

655772
type: LocalParameter
units: 033007
value: 1000.0

655770
type: LocalParameter
units: 033007
value: -1000.0

068313
type: SpeciesReference
stoichiometry: 1.0
species: 646460

646460
type: Species
notes: FORMULA: C19H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5,6,7,8-Tetrahydrofolate

068277
type: SpeciesReference
stoichiometry: 1.0
species: 646099

646099
type: Species
notes: FORMULA: HO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: hydroxide ion

649792
type: Reaction
reactant: 115218
product: 115278
name: phosphatidylcholine transporter
reactant: 115230
product: 115242
notes: GENE_ASSOCIATION: (5244.1) or (5244.3) or (5244.2) GENE_LIST: 5244.1 5244.2 5244.3 SUBSYSTEM: Transport, Extracellular
reactant: 115206
product: 115266
kinetic law: 115290
reversible: true
product: 115254
fast: false

115218
type: SpeciesReference
stoichiometry: 1.0
species: 645700

115278
type: SpeciesReference
stoichiometry: 1.0
species: 646193

646193
type: Species
notes: FORMULA: HO4P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Phosphate

115230
type: SpeciesReference
stoichiometry: 1.0
species: 646151

646151
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Phosphatidylcholine (homo sapiens)

115242
type: SpeciesReference
stoichiometry: 1.0
species: 644974

644974
type: Species
notes: FORMULA: C10H12N5O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: ADP

115206
type: SpeciesReference
stoichiometry: 1.0
species: 645088

645088
type: Species
notes: FORMULA: C10H12N5O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: ATP

115266
type: SpeciesReference
stoichiometry: 1.0
species: 646153

646153
type: Species
notes: FORMULA: C8H18NO4PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Phosphatidylcholine (homo sapiens)

660136
type: LocalParameter
units: 032971
value: 0.0

660135
type: LocalParameter
value: 0.0

660133
type: LocalParameter
units: 033007
value: 1000.0

660132
type: LocalParameter
units: 033007
value: -1000.0

115254
type: SpeciesReference
stoichiometry: 1.0
species: 645712

645454
type: Species
notes: FORMULA: C4H7O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Erythrose 4-phosphate

648049
type: Reaction
reversible: false
reactant: 070268
reactant: 070281
product: 070293
product: 070305
fast: false
product: 070317
kinetic law: 070329
notes: GENE_ASSOCIATION: (9060.1) or (9061.1) GENE_LIST: 9060.1 9061.1 SUBSYSTEM: Nucleotides
name: adenylyl-sulfate kinase

070268
type: SpeciesReference
stoichiometry: 1.0
species: 645047

645047
type: Species
notes: FORMULA: C10H12N5O10PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Adenosine 5'-phosphosulfate

070281
type: SpeciesReference
stoichiometry: 1.0
species: 645088

070293
type: SpeciesReference
stoichiometry: 1.0
species: 644974

070305
type: SpeciesReference
stoichiometry: 1.0
species: 645712

070317
type: SpeciesReference
stoichiometry: 1.0
species: 646150

646150
type: Species
notes: FORMULA: C10H11N5O13P2S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3'-Phosphoadenylyl sulfate

655987
type: LocalParameter
units: 032971
value: 500.0

655985
type: LocalParameter
value: 0.0

655983
type: LocalParameter
units: 033007
value: 1000.0

655981
type: LocalParameter
units: 033007
value: 0.0

646519
type: Species
notes: FORMULA: O3S2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Thiosulfate

648098
type: Reaction
name: aldehyde dehydrogenase (phenylacetaldehyde, NADP)
fast: false
reactant: 072303
product: 072339
reversible: false
notes: GENE_ASSOCIATION: (222.1) or (218.1) or (221.1) or (220.1) GENE_LIST: 218.1 220.1 221.1 222.1 SUBSYSTEM: Phenylalanine metabolism
product: 072327
kinetic law: 072351
reactant: 072279
reactant: 072291
product: 072315

072303
type: SpeciesReference
stoichiometry: 1.0
species: 646127

646127
type: Species
notes: FORMULA: C8H8O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Phenylacetaldehyde

072339
type: SpeciesReference
stoichiometry: 1.0
species: 646126

646126
type: Species
notes: FORMULA: C8H7O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Phenylacetic acid

072327
type: SpeciesReference
stoichiometry: 1.0
species: 646018

656218
type: LocalParameter
units: 032971
value: 500.0

656216
type: LocalParameter
value: 0.0

656214
type: LocalParameter
units: 033007
value: 1000.0

656212
type: LocalParameter
units: 033007
value: 0.0

072279
type: SpeciesReference
stoichiometry: 1.0
species: 645700

072291
type: SpeciesReference
stoichiometry: 1.0
species: 646010

072315
type: SpeciesReference
stoichiometry: 2.0
species: 645712

649093
type: Reaction
kinetic law: 101431
product: 101419
reactant: 101407
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport

658879
type: LocalParameter
units: 032971
value: 0.0

658878
type: LocalParameter
value: 0.0

658877
type: LocalParameter
units: 033007
value: 1000.0

658876
type: LocalParameter
units: 033007
value: -1000.0

101419
type: SpeciesReference
stoichiometry: 1.0
species: 646450

646450
type: Species
notes: FORMULA: C45H70N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: tetracosatetraenoyl coenzyme A

101407
type: SpeciesReference
stoichiometry: 1.0
species: 646448

646448
type: Species
notes: FORMULA: C45H70N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosatetraenoyl coenzyme A

645023
type: Species
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: L-Alanine

646606
type: Species
notes: FORMULA: C27H46O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 24-Hydroxycholesterol

644668
type: Species
notes: FORMULA: C5H6NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 1-Pyrroline-5-carboxylate

650435
type: Reaction
reactant: 128961
product: 128985
reversible: false
name: sulfate transport via oxalate countertransport (2:1)
fast: false
notes: GENE_ASSOCIATION: (65010.1) or (65010.3) or (65010.2) GENE_LIST: 65010.1 65010.2 65010.3 SUBSYSTEM: Transport, Extracellular
kinetic law: 129009
reactant: 128973
product: 128997

128961
type: SpeciesReference
stoichiometry: 1.0
species: 646115

646115
type: Species
notes: FORMULA: C2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Oxalate

128985
type: SpeciesReference
stoichiometry: 1.0
species: 646117

646117
type: Species
notes: FORMULA: C2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Oxalate

661475
type: LocalParameter
units: 032971
value: 500.0

661474
type: LocalParameter
value: 0.0

661472
type: LocalParameter
units: 033007
value: 1000.0

661471
type: LocalParameter
units: 033007
value: 0.0

128973
type: SpeciesReference
stoichiometry: 2.0
species: 646340

646340
type: Species
notes: FORMULA: O4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Sulfate

128997
type: SpeciesReference
stoichiometry: 2.0
species: 646339

646339
type: Species
notes: FORMULA: O4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sulfate

645872
type: Species
notes: FORMULA: C18H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: linoelaidic acid (all trans C18:2)

649843
type: Reaction
reactant: 116171
name: 5'-nucleotidase (GMP), extracellular
notes: GENE_ASSOCIATION: (4907.1) GENE_LIST: 4907.1 SUBSYSTEM: Nucleotides
fast: false
reversible: false
product: 116196
kinetic law: 116220
reactant: 116183
product: 116208

116171
type: SpeciesReference
stoichiometry: 1.0
species: 645658

645658
type: Species
notes: FORMULA: C10H12N5O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: GMP

116196
type: SpeciesReference
stoichiometry: 1.0
species: 645664

645664
type: Species
notes: FORMULA: C10H13N5O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Guanosine

660230
type: LocalParameter
units: 032971
value: 500.0

660228
type: LocalParameter
value: 0.0

660227
type: LocalParameter
units: 033007
value: 1000.0

660225
type: LocalParameter
units: 033007
value: 0.0

116183
type: SpeciesReference
stoichiometry: 1.0
species: 645701

645701
type: Species
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: H2O

116208
type: SpeciesReference
stoichiometry: 1.0
species: 646195

646195
type: Species
notes: FORMULA: HO4P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Phosphate

645419
type: Species
notes: FORMULA: C27H44O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Desmosterol

647240
type: Reaction
product: 037967
kinetic law: 038003
reactant: 037942
fast: false
product: 037979
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
product: 037991
reactant: 037955
reversible: false
notes: GENE_ASSOCIATION: (3176.1) GENE_LIST: 3176.1 SUBSYSTEM: Histidine Metabolism

037967
type: SpeciesReference
stoichiometry: 1.0
species: 645002

645002
type: Species
notes: FORMULA: C14H20N6O5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: S-Adenosyl-L-homocysteine

651613
type: LocalParameter
units: 032971
value: 500.0

651610
type: LocalParameter
value: 0.0

651607
type: LocalParameter
units: 033007
value: 1000.0

651606
type: LocalParameter
units: 033007
value: 0.0

037942
type: SpeciesReference
stoichiometry: 1.0
species: 645031

645031
type: Species
notes: FORMULA: C15H23N6O5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: S-Adenosyl-L-methionine

037979
type: SpeciesReference
stoichiometry: 1.0
species: 645712

037991
type: SpeciesReference
stoichiometry: 1.0
species: 645961

645961
type: Species
notes: FORMULA: C6H12N3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Methylhistamine

037955
type: SpeciesReference
stoichiometry: 1.0
species: 645772

645772
type: Species
notes: FORMULA: C5H10N3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Histamine

649909
type: Reaction
kinetic law: 117530
fast: false
reversible: true
reactant: 117494
name: UMP kinase (CTP)
reactant: 117482
product: 117518
product: 117506
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides

660350
type: LocalParameter
units: 032971
value: 0.0

660349
type: LocalParameter
value: 0.0

660347
type: LocalParameter
units: 033007
value: 1000.0

660346
type: LocalParameter
units: 033007
value: -1000.0

117494
type: SpeciesReference
stoichiometry: 1.0
species: 646549

646549
type: Species
notes: FORMULA: C9H11N2O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UMP

117482
type: SpeciesReference
stoichiometry: 1.0
species: 645254

645254
type: Species
notes: FORMULA: C9H12N3O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: CTP

117518
type: SpeciesReference
stoichiometry: 1.0
species: 646535

646535
type: Species
notes: FORMULA: C9H11N2O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDP

117506
type: SpeciesReference
stoichiometry: 1.0
species: 645148

645148
type: Species
notes: FORMULA: C9H12N3O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: CDP

646241
type: Species
notes: FORMULA: C5H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Proline

648262
type: Reaction
fast: false
product: 076925
reactant: 076901
product: 076913
reversible: false
notes: GENE_ASSOCIATION: (2571.1) or (2572.1) or (2571.2) GENE_LIST: 2571.1 2571.2 2572.1 SUBSYSTEM: Glutamate metabolism
name: Glutamate Decarboxylase
reactant: 076889
kinetic law: 076937

076925
type: SpeciesReference
stoichiometry: 1.0
species: 645212

645212
type: Species
notes: FORMULA: CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: CO2

076901
type: SpeciesReference
stoichiometry: 1.0
species: 645712

076913
type: SpeciesReference
stoichiometry: 1.0
species: 644762

644762
type: Species
notes: FORMULA: C4H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4-Aminobutanoate

076889
type: SpeciesReference
stoichiometry: 1.0
species: 645611

645611
type: Species
notes: FORMULA: C5H8NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Glutamate

656754
type: LocalParameter
units: 032971
value: 500.0

656752
type: LocalParameter
value: 0.0

656750
type: LocalParameter
units: 033007
value: 1000.0

656748
type: LocalParameter
units: 033007
value: 0.0

650703
type: Reaction
reactant: 137033
reactant: 137045
kinetic law: 137081
name: sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
product: 137057
reversible: false
fast: false
notes: GENE_ASSOCIATION: (6646.1) GENE_LIST: 6646.1 SUBSYSTEM: Cholesterol Metabolism
product: 137069

137033
type: SpeciesReference
stoichiometry: 1.0
species: 644887

644887
type: Species
notes: FORMULA: XCO2C21H31N7O15P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: R group 1 Coenzyme A homo sapiens

137045
type: SpeciesReference
stoichiometry: 1.0
species: 645184

645184
type: Species
notes: FORMULA: C27H46O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Cholesterol

662212
type: LocalParameter
units: 032971
value: 500.0

662211
type: LocalParameter
value: 0.0

662209
type: LocalParameter
units: 033007
value: 1000.0

662208
type: LocalParameter
units: 033007
value: 0.0

137057
type: SpeciesReference
stoichiometry: 1.0
species: 645223

137069
type: SpeciesReference
stoichiometry: 1.0
species: 646630

646630
type: Species
notes: FORMULA: C27H45XCO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: cholesterol ester

644728
type: Species
notes: FORMULA: C26H40N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-3-Hydroxy-2-methylbutyryl-CoA

648863
type: Reaction
kinetic law: 096275
product: 096263
reactant: 096251
fast: false
reversible: true
name: 5,6,7,8-Tetrahydrofolate exchange

658435
type: LocalParameter
units: 032971
value: 0.0

658434
type: LocalParameter
value: 0.0

658433
type: LocalParameter
units: 033007
value: 1000.0

658432
type: LocalParameter
units: 033007
value: -1000.0

096263
type: SpeciesReference
stoichiometry: 1.0
species: 646950

646950
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: lac_DASH_D_b

096251
type: SpeciesReference
stoichiometry: 1.0
species: 646462

648929
type: Reaction
kinetic law: 098066
reactant: 098006
product: 098030
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxobutanoate), mitochondrial
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) GENE_LIST: 1629.1 1738.1 593.1 594.1 594.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
product: 098042
reactant: 098018
reversible: false
fast: false
reactant: 097994
product: 098054

658611
type: LocalParameter
units: 032971
value: 500.0

658610
type: LocalParameter
value: 0.0

658609
type: LocalParameter
units: 033007
value: 1000.0

658608
type: LocalParameter
units: 033007
value: 0.0

098006
type: SpeciesReference
stoichiometry: 1.0
species: 645224

645224
type: Species
notes: FORMULA: C21H32N7O16P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Coenzyme A

098030
type: SpeciesReference
stoichiometry: 1.0
species: 645215

645215
type: Species
notes: FORMULA: CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: CO2

098042
type: SpeciesReference
stoichiometry: 1.0
species: 645800

645800
type: Species
notes: FORMULA: C25H38N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Isobutyryl-CoA

098018
type: SpeciesReference
stoichiometry: 1.0
species: 645998

645998
type: Species
notes: FORMULA: C21H26N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Nicotinamide adenine dinucleotide

097994
type: SpeciesReference
stoichiometry: 1.0
species: 644743

644743
type: Species
notes: FORMULA: C5H7O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3-Methyl-2-oxobutanoate

098054
type: SpeciesReference
stoichiometry: 1.0
species: 646006

646006
type: Species
notes: FORMULA: C21H27N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Nicotinamide adenine dinucleotide - reduced

650839
type: Reaction
kinetic law: 141354
product: 141342
reactant: 141330
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: false
name: xanthine diffusion in peroxisome

662611
type: LocalParameter
units: 032971
value: 500.0

662609
type: LocalParameter
value: 0.0

662607
type: LocalParameter
units: 033007
value: 1000.0

662606
type: LocalParameter
units: 033007
value: 0.0

141342
type: SpeciesReference
stoichiometry: 1.0
species: 646603

646603
type: Species
notes: FORMULA: C5H4N4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Xanthine

141330
type: SpeciesReference
stoichiometry: 1.0
species: 646601

646601
type: Species
notes: FORMULA: C5H4N4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Xanthine

644918
type: Species
notes: FORMULA: C3H8NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Aminoacetone

644815
type: Species
notes: FORMULA: C20H22N8O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5-Formiminotetrahydrofolate

648152
type: Reaction
kinetic law: 073847
product: 073835
reactant: 073823
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: bile acid intracellular transport

656406
type: LocalParameter
units: 032971
value: 0.0

656404
type: LocalParameter
value: 0.0

656402
type: LocalParameter
units: 033007
value: 1000.0

656400
type: LocalParameter
units: 033007
value: -1000.0

073835
type: SpeciesReference
stoichiometry: 1.0
species: 646411

646411
type: Species
notes: FORMULA: C26H45NO7S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: taurocholic acid

073823
type: SpeciesReference
stoichiometry: 1.0
species: 646414

646414
type: Species
notes: FORMULA: C26H45NO7S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: taurocholic acid

644725
type: Species
notes: FORMULA: C25H38N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-3-Hydroxybutanoyl-CoA

645239
type: Species
notes: FORMULA: C18H36NO2FULLRCO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: ceramide (homo sapiens)

647918
type: Reaction
reversible: true
reactant: 065044
name: glyceraldehyde-3-phosphate dehydrogenase
product: 065056
kinetic law: 065092
fast: false
reactant: 065020
notes: GENE_ASSOCIATION: (2597.1) or (26330.1) GENE_LIST: 2597.1 26330.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
product: 065080
product: 065068
reactant: 065032

065044
type: SpeciesReference
stoichiometry: 1.0
species: 646193

065056
type: SpeciesReference
stoichiometry: 1.0
species: 644657

644657
type: Species
notes: FORMULA: C3H4O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Phospho-D-glyceroyl phosphate

655331
type: LocalParameter
units: 032971
value: 0.0

655329
type: LocalParameter
value: 0.0

655327
type: LocalParameter
units: 033007
value: 1000.0

655325
type: LocalParameter
units: 033007
value: -1000.0

065020
type: SpeciesReference
stoichiometry: 1.0
species: 645560

645560
type: Species
notes: FORMULA: C3H5O6P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Glyceraldehyde 3-phosphate

065080
type: SpeciesReference
stoichiometry: 1.0
species: 646004

646004
type: Species
notes: FORMULA: C21H27N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinamide adenine dinucleotide - reduced

065068
type: SpeciesReference
stoichiometry: 1.0
species: 645712

065032
type: SpeciesReference
stoichiometry: 1.0
species: 645995

645995
type: Species
notes: FORMULA: C21H26N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinamide adenine dinucleotide

650874
type: Reaction
kinetic law: 142315
product: 142302
reactant: 142289
fast: false
reversible: true
name: Thiamin triphosphate exchange

662701
type: LocalParameter
units: 032971
value: 0.0

662699
type: LocalParameter
value: 0.0

662697
type: LocalParameter
units: 033007
value: 1000.0

662696
type: LocalParameter
units: 033007
value: -1000.0

142302
type: SpeciesReference
stoichiometry: 1.0
species: 647119

647119
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: yvite_b

142289
type: SpeciesReference
stoichiometry: 1.0
species: 646475

646475
type: Species
notes: FORMULA: C12H16N4O10P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Thiamin triphosphate

648733
type: Reaction
reactant: 093331
reactant: 093343
product: 093367
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
reactant: 093355
product: 093391
name: folylpolyglutamate synthetase, mitochondrial
product: 093403
kinetic law: 093415
fast: false
product: 093379
reversible: false

093331
type: SpeciesReference
stoichiometry: 4.0
species: 645091

093343
type: SpeciesReference
stoichiometry: 4.0
species: 645616

093367
type: SpeciesReference
stoichiometry: 1.0
species: 644839

644839
type: Species
notes: FORMULA: C39H45N11O18
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: pentaglutamyl folate (THF)

093355
type: SpeciesReference
stoichiometry: 1.0
species: 646465

646465
type: Species
notes: FORMULA: C19H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 5,6,7,8-Tetrahydrofolate

093391
type: SpeciesReference
stoichiometry: 4.0
species: 645716

645716
type: Species
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: H+

093403
type: SpeciesReference
stoichiometry: 4.0
species: 646196

646196
type: Species
notes: FORMULA: HO4P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Phosphate

658188
type: LocalParameter
units: 032971
value: 500.0

658187
type: LocalParameter
value: 0.0

658186
type: LocalParameter
units: 033007
value: 1000.0

658185
type: LocalParameter
units: 033007
value: 0.0

093379
type: SpeciesReference
stoichiometry: 4.0
species: 644977

650486
type: Reaction
kinetic law: 130439
product: 130427
reactant: 130415
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport

661613
type: LocalParameter
units: 032971
value: 0.0

661611
type: LocalParameter
value: 0.0

661610
type: LocalParameter
units: 033007
value: 1000.0

661608
type: LocalParameter
units: 033007
value: -1000.0

130427
type: SpeciesReference
stoichiometry: 1.0
species: 646178

646178
type: Species
notes: FORMULA: C10H16O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Perillyl alcohol

130415
type: SpeciesReference
stoichiometry: 1.0
species: 646180

646180
type: Species
notes: FORMULA: C10H16O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Perillyl alcohol

650546
type: Reaction
name: 5-methyltetrahydrofolate transport via anion exchange
kinetic law: 132178
reactant: 132142
fast: false
product: 132154
reversible: true
product: 132166
notes: GENE_ASSOCIATION: (6573.1) or (6573.2) GENE_LIST: 6573.1 6573.2 SUBSYSTEM: Transport, Extracellular
reactant: 132130

661778
type: LocalParameter
units: 032971
value: 0.0

661776
type: LocalParameter
value: 0.0

661775
type: LocalParameter
units: 033007
value: 1000.0

661773
type: LocalParameter
units: 033007
value: -1000.0

132142
type: SpeciesReference
stoichiometry: 1.0
species: 646099

132154
type: SpeciesReference
stoichiometry: 1.0
species: 644828

644828
type: Species
notes: FORMULA: C20H24N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5-Methyltetrahydrofolate

132166
type: SpeciesReference
stoichiometry: 1.0
species: 646100

132130
type: SpeciesReference
stoichiometry: 1.0
species: 644830

644830
type: Species
notes: FORMULA: C20H24N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 5-Methyltetrahydrofolate

648623
type: Reaction
notes: GENE_ASSOCIATION: (412.1) GENE_LIST: 412.1 SUBSYSTEM: Steroid Metabolism
reactant: 090605
kinetic law: 090665
reactant: 090617
product: 090653
fast: false
product: 090641
name: Steryl-sulfatase
reversible: false
product: 090629

090605
type: SpeciesReference
stoichiometry: 1.0
species: 645365

645365
type: Species
notes: FORMULA: C19H27O5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Dehydroepiandrosterone sulfate

657955
type: LocalParameter
units: 032971
value: 500.0

657953
type: LocalParameter
value: 0.0

657952
type: LocalParameter
units: 033007
value: 1000.0

657951
type: LocalParameter
units: 033007
value: 0.0

090617
type: SpeciesReference
stoichiometry: 1.0
species: 645700

090653
type: SpeciesReference
stoichiometry: 1.0
species: 646339

090641
type: SpeciesReference
stoichiometry: 1.0
species: 645712

090629
type: SpeciesReference
stoichiometry: 1.0
species: 645364

645364
type: Species
notes: FORMULA: C19H28O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Dehydroepiandrosterone

648338
type: Reaction
reactant: 079334
product: 079358
name: fatty-acyl-CoA synthase (n-C16:0CoA)
product: 079370
reactant: 079346
notes: GENE_ASSOCIATION: (2194.1) GENE_LIST: 2194.1 SUBSYSTEM: Fatty acid elongation
reactant: 079310
product: 079394
reversible: false
product: 079407
kinetic law: 079419
reactant: 079322
product: 079382
fast: false

079334
type: SpeciesReference
stoichiometry: 2.0
species: 646018

079358
type: SpeciesReference
stoichiometry: 1.0
species: 645212

079370
type: SpeciesReference
stoichiometry: 1.0
species: 645223

079346
type: SpeciesReference
stoichiometry: 1.0
species: 646424

646424
type: Species
notes: FORMULA: C35H58N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Tetradecanoyl-CoA (n-C14:0CoA)

079310
type: SpeciesReference
stoichiometry: 3.0
species: 645712

079394
type: SpeciesReference
stoichiometry: 2.0
species: 646010

079407
type: SpeciesReference
stoichiometry: 1.0
species: 646202

646202
type: Species
notes: FORMULA: C37H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Palmitoyl-CoA (n-C16:0CoA)

656987
type: LocalParameter
units: 032971
value: 500.0

656986
type: LocalParameter
value: 0.0

656984
type: LocalParameter
units: 033007
value: 1000.0

656983
type: LocalParameter
units: 033007
value: 0.0

079322
type: SpeciesReference
stoichiometry: 1.0
species: 645928

645928
type: Species
notes: FORMULA: C24H33N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Malonyl-CoA

079382
type: SpeciesReference
stoichiometry: 1.0
species: 645700

645377
type: Species
notes: FORMULA: C5H5N2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (S)-Dihydroorotate

645325
type: Species
notes: FORMULA: C27H42O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 7-Dehydrodesmosterol

649006
type: Reaction
product: 099838
product: 099790
kinetic law: 099850
fast: false
product: 099814
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reactant: 099778
reactant: 099766
notes: GENE_ASSOCIATION: (6785.1) GENE_LIST: 6785.1 SUBSYSTEM: Fatty acid elongation
reactant: 099754
product: 099826
product: 099802
reactant: 099742
reversible: false
reactant: 099730

099838
type: SpeciesReference
stoichiometry: 4.0
species: 646010

099790
type: SpeciesReference
stoichiometry: 1.0
species: 645212

658743
type: LocalParameter
units: 032971
value: 500.0

658742
type: LocalParameter
value: 0.0

658741
type: LocalParameter
units: 033007
value: 1000.0

658740
type: LocalParameter
units: 033007
value: 0.0

099814
type: SpeciesReference
stoichiometry: 1.0
species: 645470

645470
type: Species
notes: FORMULA: C41H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: eicosatetranoyl coenzyme A

099778
type: SpeciesReference
stoichiometry: 1.0
species: 646379

646379
type: Species
notes: FORMULA: C39H58N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: stearidonyl coenzyme A

099766
type: SpeciesReference
stoichiometry: 1.0
species: 646060

099754
type: SpeciesReference
stoichiometry: 4.0
species: 646018

099826
type: SpeciesReference
stoichiometry: 3.0
species: 645700

099802
type: SpeciesReference
stoichiometry: 1.0
species: 645223

099742
type: SpeciesReference
stoichiometry: 1.0
species: 645928

099730
type: SpeciesReference
stoichiometry: 5.0
species: 645712

647112
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: xolest2_hs_b

647554
type: Reaction
notes: GENE_ASSOCIATION: (1384.1) GENE_LIST: 1384.1 SUBSYSTEM: Carnitine shuttle
product: 050226
reactant: 050189
kinetic law: 050238
product: 050214
reactant: 050202
fast: false
name: carnitine O-aceyltransferase, mitochondrial
reversible: true

050226
type: SpeciesReference
stoichiometry: 1.0
species: 646219

646219
type: Species
notes: FORMULA: C24H36N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Propanoyl-CoA

050189
type: SpeciesReference
stoichiometry: 1.0
species: 645224

653601
type: LocalParameter
units: 032971
value: 0.0

653599
type: LocalParameter
value: 0.0

653597
type: LocalParameter
units: 033007
value: 1000.0

653595
type: LocalParameter
units: 033007
value: -1000.0

050214
type: SpeciesReference
stoichiometry: 1.0
species: 645247

645247
type: Species
notes: FORMULA: C7H15NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Carnitine

050202
type: SpeciesReference
stoichiometry: 1.0
species: 646162

646162
type: Species
notes: FORMULA: C10H19NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: propionyl-carnitine

649645
type: Reaction
kinetic law: 112396
product: 112384
reactant: 112372
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: estradiol intracellular transport

659870
type: LocalParameter
units: 032971
value: 0.0

659868
type: LocalParameter
value: 0.0

659867
type: LocalParameter
units: 033007
value: 1000.0

659865
type: LocalParameter
units: 033007
value: -1000.0

112384
type: SpeciesReference
stoichiometry: 1.0
species: 645482

645482
type: Species
notes: FORMULA: C18H24O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Estradiol

112372
type: SpeciesReference
stoichiometry: 1.0
species: 645484

645484
type: Species
notes: FORMULA: C18H24O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Estradiol

648344
type: Reaction
kinetic law: 079649
product: 079637
reactant: 079625
fast: false
reversible: true
name: L-Asparagine exchange

657007
type: LocalParameter
units: 032971
value: 0.0

657006
type: LocalParameter
value: 0.0

657005
type: LocalParameter
units: 033007
value: 1000.0

657004
type: LocalParameter
units: 033007
value: -1000.0

079637
type: SpeciesReference
stoichiometry: 1.0
species: 646902

646902
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: glu_DASH_L_b

079625
type: SpeciesReference
stoichiometry: 1.0
species: 645080

645080
type: Species
notes: FORMULA: C4H8N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Asparagine

645412
type: Species
notes: FORMULA: C8H11NO5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Dopamine 3-O-sulfate

648073
type: Reaction
fast: false
reactant: 071348
product: 071372
name: Isocitrate dehydrogenase (NAD+)
notes: GENE_ASSOCIATION: (3421.2 and 3420.3 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.1 and 3421.1 and 3419.1) or (3420.3 and 3421.1 and 3419.1) or (3421.1 and 3419.1 and 3420.2) or (3421.2 and 3419.1 and 3420.2) GENE_LIST: 3419.1 3420.1 3420.2 3420.3 3421.1 3421.2 SUBSYSTEM: Citric Acid Cycle
product: 071384
kinetic law: 071410
reactant: 071360
reversible: false
product: 071397

071348
type: SpeciesReference
stoichiometry: 1.0
species: 645803

645803
type: Species
notes: FORMULA: C6H5O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Isocitrate

071372
type: SpeciesReference
stoichiometry: 1.0
species: 645011

645011
type: Species
notes: FORMULA: C5H4O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 2-Oxoglutarate

071384
type: SpeciesReference
stoichiometry: 1.0
species: 645215

656099
type: LocalParameter
units: 032971
value: 500.0

656097
type: LocalParameter
value: 0.0

656095
type: LocalParameter
units: 033007
value: 1000.0

656093
type: LocalParameter
units: 033007
value: 0.0

071360
type: SpeciesReference
stoichiometry: 1.0
species: 645998

071397
type: SpeciesReference
stoichiometry: 1.0
species: 646006

647986
type: Reaction
kinetic law: 067697
product: 067685
reactant: 067673
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: cholesterol intracellular transport

655699
type: LocalParameter
units: 032971
value: 0.0

655697
type: LocalParameter
value: 0.0

655695
type: LocalParameter
units: 033007
value: 1000.0

655693
type: LocalParameter
units: 033007
value: -1000.0

067685
type: SpeciesReference
stoichiometry: 1.0
species: 645187

645187
type: Species
notes: FORMULA: C27H46O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Cholesterol

067673
type: SpeciesReference
stoichiometry: 1.0
species: 645184

648208
type: Reaction
kinetic law: 075402
product: 075389
reactant: 075377
fast: false
reversible: true
name: L-Serine exchange

656567
type: LocalParameter
units: 032971
value: 0.0

656565
type: LocalParameter
value: 0.0

656563
type: LocalParameter
units: 033007
value: 1000.0

656561
type: LocalParameter
units: 033007
value: -1000.0

075389
type: SpeciesReference
stoichiometry: 1.0
species: 646882

646882
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: elaid_b

075377
type: SpeciesReference
stoichiometry: 1.0
species: 646330

646330
type: Species
notes: FORMULA: C3H7NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Serine

649171
type: Reaction
product: 102830
reactant: 102794
reactant: 102806
reactant: 102818
product: 102854
reversible: false
fast: false
kinetic law: 102866
notes: GENE_ASSOCIATION: (51733.1) GENE_LIST: 51733.1 SUBSYSTEM: Pyrimidine Catabolism
name: b-ureidopropionase
product: 102842

102830
type: SpeciesReference
stoichiometry: 1.0
species: 645013

102794
type: SpeciesReference
stoichiometry: 1.0
species: 645134

645134
type: Species
notes: FORMULA: C4H7N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Carbamoyl-beta-alanine

102806
type: SpeciesReference
stoichiometry: 1.0
species: 645700

102818
type: SpeciesReference
stoichiometry: 2.0
species: 645712

102854
type: SpeciesReference
stoichiometry: 1.0
species: 646027

646027
type: Species
notes: FORMULA: H4N
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Ammonium

659017
type: LocalParameter
units: 032971
value: 500.0

659016
type: LocalParameter
value: 0.0

659014
type: LocalParameter
units: 033007
value: 1000.0

659013
type: LocalParameter
units: 033007
value: 0.0

102842
type: SpeciesReference
stoichiometry: 1.0
species: 645212

645322
type: Species
notes: FORMULA: C9H13N3O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: Deoxycytidine

646595
type: Species
notes: FORMULA: C16H31O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: omega hydroxy hexadecanoate (n-C16:0)

650790
type: Reaction
kinetic law: 139843
product: 139831
reactant: 139819
fast: false
reversible: true
name: 5-Formyltetrahydrofolate exchange

662461
type: LocalParameter
units: 032971
value: 0.0

662459
type: LocalParameter
value: 0.0

662457
type: LocalParameter
units: 033007
value: 1000.0

662456
type: LocalParameter
units: 033007
value: -1000.0

139831
type: SpeciesReference
stoichiometry: 1.0
species: 647113

647113
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: xolest_hs_b

139819
type: SpeciesReference
stoichiometry: 1.0
species: 644818

644818
type: Species
notes: FORMULA: C20H21N7O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 5-Formyltetrahydrofolate

644662
type: Species
notes: FORMULA: C7H9N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 1-Methylnicotinamide

650603
type: Reaction
product: 133876
reactant: 133816
product: 133864
product: 133852
name: sulfite oxidase
reversible: false
reactant: 133828
reactant: 133840
kinetic law: 133889
notes: GENE_ASSOCIATION: (6821.1) GENE_LIST: 6821.1 SUBSYSTEM: Cysteine Metabolism
fast: false

133876
type: SpeciesReference
stoichiometry: 1.0
species: 646339

133816
type: SpeciesReference
stoichiometry: 2.0
species: 645535

645535
type: Species
notes: FORMULA: C42H54FeN8O6S2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Ferricytochrome c

133864
type: SpeciesReference
stoichiometry: 2.0
species: 645712

133852
type: SpeciesReference
stoichiometry: 2.0
species: 645538

645538
type: Species
notes: FORMULA: C42H54FeN8O6S2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Ferrocytochrome C

133828
type: SpeciesReference
stoichiometry: 1.0
species: 645700

133840
type: SpeciesReference
stoichiometry: 1.0
species: 646336

646336
type: Species
notes: FORMULA: O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sulfite

661937
type: LocalParameter
units: 032971
value: 500.0

661936
type: LocalParameter
value: 0.0

661934
type: LocalParameter
units: 033007
value: 1000.0

661933
type: LocalParameter
units: 033007
value: 0.0

647429
type: Reaction
reactant: 045558
reactant: 045534
kinetic law: 045619
name: folylpolyglutamate synthetase, mitochondrial
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
reversible: false
fast: false
reactant: 045546
product: 045595
product: 045582
product: 045607
product: 045570

045558
type: SpeciesReference
stoichiometry: 1.0
species: 645616

045534
type: SpeciesReference
stoichiometry: 1.0
species: 644854

644854
type: Species
notes: FORMULA: C44H51N12O21
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: hexaglutamyl folate (THF)

652841
type: LocalParameter
units: 032971
value: 500.0

652838
type: LocalParameter
value: 0.0

652835
type: LocalParameter
units: 033007
value: 1000.0

652832
type: LocalParameter
units: 033007
value: 0.0

045546
type: SpeciesReference
stoichiometry: 1.0
species: 645091

045595
type: SpeciesReference
stoichiometry: 1.0
species: 645716

045582
type: SpeciesReference
stoichiometry: 1.0
species: 644977

045607
type: SpeciesReference
stoichiometry: 1.0
species: 646196

045570
type: SpeciesReference
stoichiometry: 1.0
species: 644866

644866
type: Species
notes: FORMULA: C49H57N13O24
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: heptaglutamyl folate (THF)

650138
type: Reaction
kinetic law: 122059
notes: GENE_ASSOCIATION: (130.1) or (284273.2) or (126.1) or (131.1) or (124.1) or (125.1 and 124.1) or (125.1 and 126.1) or (137872.1) or (125.1) or (127.1) or (126.1 and 124.1) or (284273.1) or (128.1) GENE_LIST: 124.1 125.1 126.1 127.1 128.1 130.1 131.1 137872.1 284273.1 284273.2 SUBSYSTEM: Pyruvate Metabolism
reactant: 121999
name: alcohol dehydrogenase (D-1,2-propanediol)
reactant: 122011
product: 122047
product: 122035
reversible: false
fast: false
product: 122023

660821
type: LocalParameter
units: 032971
value: 500.0

660819
type: LocalParameter
value: 0.0

660818
type: LocalParameter
units: 033007
value: 1000.0

660816
type: LocalParameter
units: 033007
value: 0.0

121999
type: SpeciesReference
stoichiometry: 1.0
species: 644645

644645
type: Species
notes: FORMULA: C3H8O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (R)-Propane-1,2-diol

122011
type: SpeciesReference
stoichiometry: 1.0
species: 645995

122047
type: SpeciesReference
stoichiometry: 1.0
species: 646004

122035
type: SpeciesReference
stoichiometry: 1.0
species: 645850

645850
type: Species
notes: FORMULA: C3H6O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Lactaldehyde

122023
type: SpeciesReference
stoichiometry: 1.0
species: 645712

646785
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Rtotal_b

646267
type: Species
notes: FORMULA: C4H14N2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Putrescine

648949
type: Reaction
product: 098607
product: 098583
name: fatty-acyl-CoA synthase (n-C14:0CoA)
product: 098595
kinetic law: 098620
reactant: 098522
notes: GENE_ASSOCIATION: (2194.1) GENE_LIST: 2194.1 SUBSYSTEM: Fatty acid elongation
reactant: 098546
reactant: 098510
product: 098558
product: 098570
reversible: false
fast: false
reactant: 098534

098607
type: SpeciesReference
stoichiometry: 1.0
species: 646424

098583
type: SpeciesReference
stoichiometry: 1.0
species: 645700

098595
type: SpeciesReference
stoichiometry: 2.0
species: 646010

658650
type: LocalParameter
units: 032971
value: 500.0

658649
type: LocalParameter
value: 0.0

658648
type: LocalParameter
units: 033007
value: 1000.0

658647
type: LocalParameter
units: 033007
value: 0.0

098522
type: SpeciesReference
stoichiometry: 3.0
species: 645712

098546
type: SpeciesReference
stoichiometry: 2.0
species: 646018

098510
type: SpeciesReference
stoichiometry: 1.0
species: 645323

645323
type: Species
notes: FORMULA: C33H54N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Dodecanoyl-CoA (n-C12:0CoA)

098558
type: SpeciesReference
stoichiometry: 1.0
species: 645212

098570
type: SpeciesReference
stoichiometry: 1.0
species: 645223

098534
type: SpeciesReference
stoichiometry: 1.0
species: 645928

646457
type: Species
notes: FORMULA: C27H45O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

646354
type: Species
notes: FORMULA: C18H37NO5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sphingosine 1-phosphate

645880
type: Species
notes: FORMULA: C18H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: linoleic acid (all cis C18:2) n-6

647446
type: Reaction
kinetic law: 046217
product: 046205
reactant: 046193
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: bile acid intracellular transport

652950
type: LocalParameter
units: 032971
value: 0.0

652948
type: LocalParameter
value: 0.0

652945
type: LocalParameter
units: 033007
value: 1000.0

652942
type: LocalParameter
units: 033007
value: -1000.0

046205
type: SpeciesReference
stoichiometry: 1.0
species: 646420

046193
type: SpeciesReference
stoichiometry: 1.0
species: 646421

646421
type: Species
notes: FORMULA: C26H45NO6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: taurochenodeoxycholate

648430
type: Reaction
reactant: 082970
product: 082983
fast: false
reversible: true
reactant: 082958
name: UMP kinase (dATP),nuclear
product: 082995
kinetic law: 083007
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides

082970
type: SpeciesReference
stoichiometry: 1.0
species: 646552

646552
type: Species
notes: FORMULA: C9H11N2O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: UMP

082983
type: SpeciesReference
stoichiometry: 1.0
species: 645280

645280
type: Species
notes: FORMULA: C10H12N5O9P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dADP

082958
type: SpeciesReference
stoichiometry: 1.0
species: 645290

645290
type: Species
notes: FORMULA: C10H12N5O12P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dATP

082995
type: SpeciesReference
stoichiometry: 1.0
species: 646538

646538
type: Species
notes: FORMULA: C9H11N2O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: UDP

657365
type: LocalParameter
units: 032971
value: 0.0

657364
type: LocalParameter
value: 0.0

657363
type: LocalParameter
units: 033007
value: 1000.0

657361
type: LocalParameter
units: 033007
value: -1000.0

645221
type: Species
notes: FORMULA: CO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Carbon monoxide

647924
type: Reaction
product: 065296
reactant: 065272
reversible: false
name: 24-dehydrocholesterol reductase [Precursor]
notes: GENE_ASSOCIATION: (1718.1) GENE_LIST: 1718.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
product: 065308
reactant: 065284
kinetic law: 065321

065296
type: SpeciesReference
stoichiometry: 1.0
species: 645514

645514
type: Species
notes: FORMULA: C27H31N9O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Flavin adenine dinucleotide oxidized

065272
type: SpeciesReference
stoichiometry: 1.0
species: 645520

645520
type: Species
notes: FORMULA: C27H33N9O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Flavin adenine dinucleotide reduced

065308
type: SpeciesReference
stoichiometry: 1.0
species: 646751

646751
type: Species
notes: FORMULA: C27H46O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Zymostenol

065284
type: SpeciesReference
stoichiometry: 1.0
species: 646750

646750
type: Species
notes: FORMULA: C27H44O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: zymosterol

655359
type: LocalParameter
units: 032971
value: 500.0

655357
type: LocalParameter
value: 0.0

655355
type: LocalParameter
units: 033007
value: 1000.0

655353
type: LocalParameter
units: 033007
value: 0.0

645167
type: Species
notes: FORMULA: C5H14NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: Choline

645077
type: Species
notes: FORMULA: C6H8O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Ascorbate

647969
type: Reaction
kinetic law: 067082
product: 067070
reactant: 067058
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: phosphatidylethanolamine scramblase

655569
type: LocalParameter
units: 032971
value: 0.0

655567
type: LocalParameter
value: 0.0

655565
type: LocalParameter
units: 033007
value: 1000.0

655563
type: LocalParameter
units: 033007
value: -1000.0

067070
type: SpeciesReference
stoichiometry: 1.0
species: 646172

646172
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: phosphatidylethanolamine (homo sapiens)

067058
type: SpeciesReference
stoichiometry: 1.0
species: 646168

646168
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: phosphatidylethanolamine (homo sapiens)

647872
type: Reaction
name: nucleoside-diphosphate kinase (ATP:dCDP), mitochondrial
reactant: 063200
kinetic law: 063249
reversible: true
product: 063237
notes: GENE_ASSOCIATION: (4833.1) GENE_LIST: 4833.1 SUBSYSTEM: Nucleotides
product: 063225
fast: false
reactant: 063213

063200
type: SpeciesReference
stoichiometry: 1.0
species: 645091

655114
type: LocalParameter
units: 032971
value: 0.0

655112
type: LocalParameter
value: 0.0

655110
type: LocalParameter
units: 033007
value: 1000.0

655108
type: LocalParameter
units: 033007
value: -1000.0

063237
type: SpeciesReference
stoichiometry: 1.0
species: 645316

645316
type: Species
notes: FORMULA: C9H12N3O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dCTP

063225
type: SpeciesReference
stoichiometry: 1.0
species: 644977

063213
type: SpeciesReference
stoichiometry: 1.0
species: 645296

645296
type: Species
notes: FORMULA: C9H12N3O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dCDP

645742
type: Species
notes: FORMULA: C16H29O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Hexadecenoate (n-C16:1)

650863
type: Reaction
fast: false
name: carnitine O-palmitoyltransferase
reactant: 142042
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) GENE_LIST: 126129.1 1374.1 1375.1 1375.2 1375.3 1375.4 SUBSYSTEM: Carnitine shuttle
kinetic law: 142078
reactant: 142030
product: 142066
product: 142054
reversible: false

142042
type: SpeciesReference
stoichiometry: 1.0
species: 646088

646088
type: Species
notes: FORMULA: C39H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: trans-Octadec-2-enoyl-CoA

662671
type: LocalParameter
units: 032971
value: 500.0

662669
type: LocalParameter
value: 0.0

662667
type: LocalParameter
units: 033007
value: 1000.0

662666
type: LocalParameter
units: 033007
value: 0.0

142030
type: SpeciesReference
stoichiometry: 1.0
species: 645244

142066
type: SpeciesReference
stoichiometry: 1.0
species: 645479

645479
type: Species
notes: FORMULA: C25H47NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Elaidic carnitine

142054
type: SpeciesReference
stoichiometry: 1.0
species: 645223

644899
type: Species
notes: FORMULA: CO2FULLR
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: R total

650727
type: Reaction
reversible: false
product: 137937
notes: GENE_ASSOCIATION: (60386.1) GENE_LIST: 60386.1 SUBSYSTEM: Transport, Mitochondrial
reactant: 137913
reactant: 137901
name: dTDP transport via dUDP antiport
kinetic law: 137949
product: 137925
fast: false

137937
type: SpeciesReference
stoichiometry: 1.0
species: 645433

645433
type: Species
notes: FORMULA: C9H11N2O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dUDP

137913
type: SpeciesReference
stoichiometry: 1.0
species: 645434

645434
type: Species
notes: FORMULA: C9H11N2O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dUDP

137901
type: SpeciesReference
stoichiometry: 1.0
species: 645421

645421
type: Species
notes: FORMULA: C10H13N2O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dTDP

662279
type: LocalParameter
units: 032971
value: 500.0

662278
type: LocalParameter
value: 0.0

662276
type: LocalParameter
units: 033007
value: 1000.0

662275
type: LocalParameter
units: 033007
value: 0.0

137925
type: SpeciesReference
stoichiometry: 1.0
species: 645422

645422
type: Species
notes: FORMULA: C10H13N2O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dTDP

645164
type: Species
notes: FORMULA: C5H14NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Choline

649588
type: Reaction
product: 111321
product: 111309
name: formate dehydrogenase
fast: false
reactant: 111296
kinetic law: 111333
notes: GENE_ASSOCIATION: (10840.1) GENE_LIST: 10840.1 SUBSYSTEM: Fatty Acid Metabolism
reactant: 111284
reversible: false

111321
type: SpeciesReference
stoichiometry: 1.0
species: 646004

111309
type: SpeciesReference
stoichiometry: 1.0
species: 645212

111296
type: SpeciesReference
stoichiometry: 1.0
species: 645995

659767
type: LocalParameter
units: 032971
value: 500.0

659766
type: LocalParameter
value: 0.0

659764
type: LocalParameter
units: 033007
value: 1000.0

659763
type: LocalParameter
units: 033007
value: 0.0

111284
type: SpeciesReference
stoichiometry: 1.0
species: 645542

645542
type: Species
notes: FORMULA: CH1O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Formate

648722
type: Reaction
reactant: 093071
kinetic law: 093121
product: 093095
product: 093108
reactant: 093083
notes: GENE_ASSOCIATION: (29922.2) or (10201.1) or (4831.1 and 4830.1) or (4832.1) or (4831.1 and 4830.2) or (29922.1) GENE_LIST: 10201.1 29922.1 29922.2 4830.1 4830.2 4831.1 4832.1 SUBSYSTEM: Nucleotides
fast: false
reversible: true
name: nucleoside-diphosphate kinase (ATP:dIDP)

093071
type: SpeciesReference
stoichiometry: 1.0
species: 645088

658168
type: LocalParameter
units: 032971
value: 0.0

658167
type: LocalParameter
value: 0.0

658166
type: LocalParameter
units: 033007
value: 1000.0

658165
type: LocalParameter
units: 033007
value: -1000.0

093095
type: SpeciesReference
stoichiometry: 1.0
species: 644974

093108
type: SpeciesReference
stoichiometry: 1.0
species: 645385

645385
type: Species
notes: FORMULA: C10H11N4O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dITP

093083
type: SpeciesReference
stoichiometry: 1.0
species: 645379

645379
type: Species
notes: FORMULA: C10H11N4O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dIDP

646028
type: Species
notes: FORMULA: H4N
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Ammonium

649939
type: Reaction
notes: GENE_ASSOCIATION: (3145.1) GENE_LIST: 3145.1 SUBSYSTEM: Heme Biosynthesis
reactant: 118108
reversible: false
reactant: 118120
fast: false
product: 118144
kinetic law: 118156
name: hydroxymethylbilane synthase
product: 118132

118108
type: SpeciesReference
stoichiometry: 1.0
species: 645700

118120
type: SpeciesReference
stoichiometry: 4.0
species: 646216

646216
type: Species
notes: FORMULA: C10H13N2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Porphobilinogen

118144
type: SpeciesReference
stoichiometry: 4.0
species: 646027

660405
type: LocalParameter
units: 032971
value: 500.0

660404
type: LocalParameter
value: 0.0

660402
type: LocalParameter
units: 033007
value: 1000.0

660401
type: LocalParameter
units: 033007
value: 0.0

118132
type: SpeciesReference
stoichiometry: 1.0
species: 645773

645773
type: Species
notes: FORMULA: C40H38N4O17
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hydroxymethylbilane

650105
type: Reaction
reactant: 121480
product: 121504
product: 121492
fast: false
notes: GENE_ASSOCIATION: (6675.1) or (91373.1) GENE_LIST: 6675.1 91373.1 SUBSYSTEM: Aminosugar Metabolism
reactant: 121468
kinetic law: 121516
name: UDP-N-acetylglucosamine diphosphorylase
reactant: 121455
reversible: false

121480
type: SpeciesReference
stoichiometry: 1.0
species: 646574

646574
type: Species
notes: FORMULA: C9H11N2O15P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UTP

121504
type: SpeciesReference
stoichiometry: 1.0
species: 646534

646534
type: Species
notes: FORMULA: C17H25N3O17P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDP-N-acetyl-D-glucosamine

121492
type: SpeciesReference
stoichiometry: 1.0
species: 646222

646222
type: Species
notes: FORMULA: HO7P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Diphosphate

121468
type: SpeciesReference
stoichiometry: 1.0
species: 645712

660760
type: LocalParameter
units: 032971
value: 500.0

660759
type: LocalParameter
value: 0.0

660757
type: LocalParameter
units: 033007
value: 1000.0

660756
type: LocalParameter
units: 033007
value: 0.0

121455
type: SpeciesReference
stoichiometry: 1.0
species: 644951

644951
type: Species
notes: FORMULA: C8H14NO9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Acetyl-D-glucosamine 1-phosphate

650539
type: Reaction
reversible: false
product: 132034
kinetic law: 132046
product: 132022
reactant: 131998
notes: GENE_ASSOCIATION: (11343.1) or (11343.2) GENE_LIST: 11343.1 11343.2 SUBSYSTEM: Triacylglycerol Synthesis
fast: false
reactant: 131986
product: 132010
name: lipase

132034
type: SpeciesReference
stoichiometry: 1.0
species: 645712

661761
type: LocalParameter
units: 032971
value: 500.0

661760
type: LocalParameter
value: 0.0

661758
type: LocalParameter
units: 033007
value: 1000.0

661757
type: LocalParameter
units: 033007
value: 0.0

132022
type: SpeciesReference
stoichiometry: 1.0
species: 645643

645643
type: Species
notes: FORMULA: C3H8O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Glycerol

131998
type: SpeciesReference
stoichiometry: 1.0
species: 645922

645922
type: Species
notes: FORMULA: C3H7O2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: monoacylglycerol 2 (homo sapiens)

131986
type: SpeciesReference
stoichiometry: 1.0
species: 645700

132010
type: SpeciesReference
stoichiometry: 1.0
species: 644890

644890
type: Species
notes: FORMULA: CO2FULLR2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: R total 2 position

646382
type: Species
notes: FORMULA: C39H58N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: stearidonyl coenzyme A

649270
type: Reaction
name: phosphomevalonate kinase
product: 104810
reversible: false
reactant: 104798
notes: GENE_ASSOCIATION: (10654.1) GENE_LIST: 10654.1 SUBSYSTEM: Cholesterol Metabolism
product: 104822
kinetic law: 104834
reactant: 104786
fast: false

104810
type: SpeciesReference
stoichiometry: 1.0
species: 644813

644813
type: Species
notes: FORMULA: C6H10O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: (R)-5-Diphosphomevalonate

104798
type: SpeciesReference
stoichiometry: 1.0
species: 645094

645094
type: Species
notes: FORMULA: C10H12N5O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: ATP

104822
type: SpeciesReference
stoichiometry: 1.0
species: 644980

644980
type: Species
notes: FORMULA: C10H12N5O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: ADP

659198
type: LocalParameter
units: 032971
value: 500.0

659197
type: LocalParameter
value: 0.0

659196
type: LocalParameter
units: 033007
value: 1000.0

659194
type: LocalParameter
units: 033007
value: 0.0

104786
type: SpeciesReference
stoichiometry: 1.0
species: 644833

644833
type: Species
notes: FORMULA: C6H10O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: (R)-5-Phosphomevalonate

644777
type: Species
notes: FORMULA: C6H7N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4-Imidazolone-5-propanoate

644869
type: Species
notes: FORMULA: C6H11NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-2-Aminoadipate 6-semialdehyde

645335
type: Species
notes: FORMULA: C10H12N5O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dGDP

647711
type: Reaction
reactant: 056818
product: 056854
fast: false
name: L-lactate reversible transport via proton symport
reversible: true
product: 056842
kinetic law: 056866
reactant: 056830
notes: GENE_ASSOCIATION: (9123.1) or (6566.1) or (23539.1) or (9194.1) GENE_LIST: 23539.1 6566.1 9123.1 9194.1 SUBSYSTEM: Transport, Extracellular

056818
type: SpeciesReference
stoichiometry: 1.0
species: 645713

645713
type: Species
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: H+

056854
type: SpeciesReference
stoichiometry: 1.0
species: 645845

645845
type: Species
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Lactate

056842
type: SpeciesReference
stoichiometry: 1.0
species: 645712

654365
type: LocalParameter
units: 032971
value: 0.0

654363
type: LocalParameter
value: 0.0

654361
type: LocalParameter
units: 033007
value: 1000.0

654359
type: LocalParameter
units: 033007
value: -1000.0

056830
type: SpeciesReference
stoichiometry: 1.0
species: 645847

645847
type: Species
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Lactate

644692
type: Species
notes: FORMULA: C25H36N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 2-Methylprop-2-enoyl-CoA

645250
type: Species
notes: FORMULA: C21H30O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Cortisol

650747
type: Reaction
name: nucleoside-diphosphate kinase (ATP:IDP), nuclear
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) GENE_LIST: 4830.1 4830.2 4831.1 SUBSYSTEM: Nucleotides
fast: false
product: 138637
product: 138625
reactant: 138600
kinetic law: 138649
reactant: 138612
reversible: true

138637
type: SpeciesReference
stoichiometry: 1.0
species: 645830

645830
type: Species
notes: FORMULA: C10H11N4O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: ITP

138625
type: SpeciesReference
stoichiometry: 1.0
species: 644978

644978
type: Species
notes: FORMULA: C10H12N5O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: ADP

138600
type: SpeciesReference
stoichiometry: 1.0
species: 645092

645092
type: Species
notes: FORMULA: C10H12N5O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: ATP

662336
type: LocalParameter
units: 032971
value: 0.0

662335
type: LocalParameter
value: 0.0

662333
type: LocalParameter
units: 033007
value: 1000.0

662332
type: LocalParameter
units: 033007
value: -1000.0

138612
type: SpeciesReference
stoichiometry: 1.0
species: 645808

645808
type: Species
notes: FORMULA: C10H11N4O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: IDP

649348
type: Reaction
product: 106445
kinetic law: 106469
notes: GENE_ASSOCIATION: (6005.1) or (57127.1) GENE_LIST: 57127.1 6005.1 SUBSYSTEM: Transport, Extracellular
reactant: 106433
fast: false
name: ammonia transport via proton antiport
product: 106457
reactant: 106421
reversible: true

106445
type: SpeciesReference
stoichiometry: 1.0
species: 645712

659331
type: LocalParameter
units: 032971
value: 0.0

659329
type: LocalParameter
value: 0.0

659328
type: LocalParameter
units: 033007
value: 1000.0

659326
type: LocalParameter
units: 033007
value: -1000.0

106433
type: SpeciesReference
stoichiometry: 1.0
species: 646027

106457
type: SpeciesReference
stoichiometry: 1.0
species: 646028

106421
type: SpeciesReference
stoichiometry: 1.0
species: 645713

644956
type: Species
notes: FORMULA: C8H15NO6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: N-Acetyl-D-glucosamine

644620
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0
name: Lysosome

648151
type: Reaction
kinetic law: 073811
product: 073799
reactant: 073787
fast: false
reversible: true
name: L-Glutamine exchange

656399
type: LocalParameter
units: 032971
value: 0.0

656397
type: LocalParameter
value: 0.0

656395
type: LocalParameter
units: 033007
value: 1000.0

656393
type: LocalParameter
units: 033007
value: -1000.0

073799
type: SpeciesReference
stoichiometry: 1.0
species: 646879

073787
type: SpeciesReference
stoichiometry: 1.0
species: 645605

645605
type: Species
notes: FORMULA: C5H10N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Glutamine

647094
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tymsf_b

646505
type: Species
notes: FORMULA: X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Oxidized thioredoxin

648661
type: Reaction
reversible: false
kinetic law: 091695
reactant: 091647
notes: GENE_ASSOCIATION: (56848.1) GENE_LIST: 56848.1 SUBSYSTEM: Sphingolipid Metabolism
product: 091683
name: sphingosine kinase 2
reactant: 091635
fast: false
product: 091659
product: 091671

658053
type: LocalParameter
units: 032971
value: 500.0

658051
type: LocalParameter
value: 0.0

658050
type: LocalParameter
units: 033007
value: 1000.0

658049
type: LocalParameter
units: 033007
value: 0.0

091647
type: SpeciesReference
stoichiometry: 1.0
species: 646346

646346
type: Species
notes: FORMULA: C18H38NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sphingosine

091683
type: SpeciesReference
stoichiometry: 1.0
species: 646354

091635
type: SpeciesReference
stoichiometry: 1.0
species: 645088

091659
type: SpeciesReference
stoichiometry: 1.0
species: 644974

091671
type: SpeciesReference
stoichiometry: 1.0
species: 645712

648196
type: Reaction
reversible: false
name: cytochrome P450 2C9
reactant: 075039
product: 075064
reactant: 075027
notes: GENE_ASSOCIATION: (1559.1) or (1557.1) GENE_LIST: 1557.1 1559.1 SUBSYSTEM: Limonene and pinene degradation
product: 075076
fast: false
reactant: 075015
reactant: 075052
kinetic law: 075100
product: 075088

075039
type: SpeciesReference
stoichiometry: 1.0
species: 646018

075064
type: SpeciesReference
stoichiometry: 1.0
species: 645140

645140
type: Species
notes: FORMULA: C10H16O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (E)-carveol

075027
type: SpeciesReference
stoichiometry: 1.0
species: 645868

645868
type: Species
notes: FORMULA: C10H16
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Limonene

075076
type: SpeciesReference
stoichiometry: 1.0
species: 645700

075015
type: SpeciesReference
stoichiometry: 1.0
species: 645712

075052
type: SpeciesReference
stoichiometry: 1.0
species: 646060

656532
type: LocalParameter
units: 032971
value: 500.0

656530
type: LocalParameter
value: 0.0

656528
type: LocalParameter
units: 033007
value: 1000.0

656526
type: LocalParameter
units: 033007
value: 0.0

075088
type: SpeciesReference
stoichiometry: 1.0
species: 646010

645575
type: Species
notes: FORMULA: C26H43NO6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: glycocholate

648368
type: Reaction
kinetic law: 080470
product: 080458
reactant: 080446
fast: false
reversible: true
name: pentaglutamyl folate (THF) exchange

657197
type: LocalParameter
units: 032971
value: 0.0

657196
type: LocalParameter
value: 0.0

657195
type: LocalParameter
units: 033007
value: 1000.0

657194
type: LocalParameter
units: 033007
value: -1000.0

080458
type: SpeciesReference
stoichiometry: 1.0
species: 646903

646903
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: gly_b

080446
type: SpeciesReference
stoichiometry: 1.0
species: 644836

644836
type: Species
notes: FORMULA: C39H45N11O18
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: pentaglutamyl folate (THF)

647171
type: Reaction
fast: false
product: 035157
reactant: 035133
reactant: 035121
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
product: 035145
reversible: true
kinetic law: 035169
name: cytidylate kinase (CMP),nuclear

035157
type: SpeciesReference
stoichiometry: 1.0
species: 645151

645151
type: Species
notes: FORMULA: C9H12N3O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: CDP

035133
type: SpeciesReference
stoichiometry: 1.0
species: 645209

645209
type: Species
notes: FORMULA: C9H12N3O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: CMP

035121
type: SpeciesReference
stoichiometry: 1.0
species: 645092

035145
type: SpeciesReference
stoichiometry: 1.0
species: 644978

651177
type: LocalParameter
units: 032971
value: 0.0

651174
type: LocalParameter
value: 0.0

651171
type: LocalParameter
units: 033007
value: 1000.0

651170
type: LocalParameter
units: 033007
value: -1000.0

647398
type: Reaction
kinetic law: 044263
product: 044251
reactant: 044239
notes: GENE_ASSOCIATION: (6580.1) or (6582.2) or (6582.1) GENE_LIST: 6580.1 6582.1 6582.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Serotonin uniport

652631
type: LocalParameter
units: 032971
value: 0.0

652628
type: LocalParameter
value: 0.0

652625
type: LocalParameter
units: 033007
value: 1000.0

652622
type: LocalParameter
units: 033007
value: -1000.0

044251
type: SpeciesReference
stoichiometry: 1.0
species: 646363

646363
type: Species
notes: FORMULA: C10H13N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Serotonin

044239
type: SpeciesReference
stoichiometry: 1.0
species: 646364

646364
type: Species
notes: FORMULA: C10H13N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Serotonin

646743
type: Species
notes: FORMULA: C5H10O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Xylulose

650156
type: Reaction
product: 122505
kinetic law: 122529
fast: false
reactant: 122481
product: 122493
name: 1,3-Diaminopropane:oxygen oxidoreductase (deaminating)
reactant: 122455
reactant: 122468
notes: GENE_ASSOCIATION: (8639.1) or (26.1) or (314.2) or (314.1) GENE_LIST: 26.1 314.1 314.2 8639.1 SUBSYSTEM: beta-Alanine metabolism
product: 122517
reversible: false

122505
type: SpeciesReference
stoichiometry: 1.0
species: 645692

660854
type: LocalParameter
units: 032971
value: 500.0

660852
type: LocalParameter
value: 0.0

660851
type: LocalParameter
units: 033007
value: 1000.0

660849
type: LocalParameter
units: 033007
value: 0.0

122481
type: SpeciesReference
stoichiometry: 1.0
species: 646060

122493
type: SpeciesReference
stoichiometry: 1.0
species: 645100

122455
type: SpeciesReference
stoichiometry: 1.0
species: 644656

122468
type: SpeciesReference
stoichiometry: 1.0
species: 645700

122517
type: SpeciesReference
stoichiometry: 1.0
species: 646027

650634
type: Reaction
fast: false
notes: GENE_ASSOCIATION: (5167.1) or (5169.1) or (5168.1) GENE_LIST: 5167.1 5168.1 5169.1 SUBSYSTEM: NAD Metabolism
kinetic law: 134833
reactant: 134773
reactant: 134785
name: nicotinate-nucleotide adenylyltransferase
reactant: 134797
reversible: false
product: 134821
product: 134809

662020
type: LocalParameter
units: 032971
value: 500.0

662018
type: LocalParameter
value: 0.0

662017
type: LocalParameter
units: 033007
value: 1000.0

662015
type: LocalParameter
units: 033007
value: 0.0

134773
type: SpeciesReference
stoichiometry: 1.0
species: 645088

134785
type: SpeciesReference
stoichiometry: 1.0
species: 645712

134797
type: SpeciesReference
stoichiometry: 1.0
species: 646036

646036
type: Species
notes: FORMULA: C11H12NO9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinate D-ribonucleotide

134821
type: SpeciesReference
stoichiometry: 1.0
species: 646222

134809
type: SpeciesReference
stoichiometry: 1.0
species: 645406

645406
type: Species
notes: FORMULA: C21H24N6O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Deamino-NAD+

644860
type: Species
notes: FORMULA: C49H55N13O24
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: heptaglutamyl folate (DHF)

647516
type: Reaction
notes: GENE_ASSOCIATION: (2628.1) GENE_LIST: 2628.1 SUBSYSTEM: Urea cycle/amino group metabolism
reactant: 048863
name: glycine amidinotransferase (c)
fast: false
reactant: 048851
kinetic law: 048900
product: 048876
product: 048888
reversible: true

048863
type: SpeciesReference
stoichiometry: 1.0
species: 645628

645628
type: Species
notes: FORMULA: C2H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Glycine

048851
type: SpeciesReference
stoichiometry: 1.0
species: 645070

645070
type: Species
notes: FORMULA: C6H15N4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Arginine

653404
type: LocalParameter
units: 032971
value: 0.0

653402
type: LocalParameter
value: 0.0

653400
type: LocalParameter
units: 033007
value: 1000.0

653397
type: LocalParameter
units: 033007
value: -1000.0

048876
type: SpeciesReference
stoichiometry: 1.0
species: 645682

645682
type: Species
notes: FORMULA: C3H7N3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Guanidinoacetate

048888
type: SpeciesReference
stoichiometry: 1.0
species: 646108

646108
type: Species
notes: FORMULA: C5H13N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Ornithine

648050
type: Reaction
kinetic law: 070366
product: 070353
reactant: 070341
notes: GENE_ASSOCIATION: (6582.1) or (6582.2) GENE_LIST: 6582.1 6582.2 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: debrisoquine uniport

655994
type: LocalParameter
units: 032971
value: 0.0

655992
type: LocalParameter
value: 0.0

655990
type: LocalParameter
units: 033007
value: 1000.0

655988
type: LocalParameter
units: 033007
value: -1000.0

070353
type: SpeciesReference
stoichiometry: 1.0
species: 645326

645326
type: Species
notes: FORMULA: C10H14N3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: debrisoquine

070341
type: SpeciesReference
stoichiometry: 1.0
species: 645328

645328
type: Species
notes: FORMULA: C10H14N3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: debrisoquine

645902
type: Species
notes: FORMULA: C39H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: gamma-linolenoyl-CoA

650651
type: Reaction
reactant: 135438
reactant: 135426
product: 135450
notes: GENE_ASSOCIATION: (25796.1) GENE_LIST: 25796.1 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
product: 135462
reversible: false
name: 6-phosphogluconolactonase
kinetic law: 135474

135438
type: SpeciesReference
stoichiometry: 1.0
species: 645700

135426
type: SpeciesReference
stoichiometry: 1.0
species: 644848

644848
type: Species
notes: FORMULA: C6H9O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 6-phospho-D-glucono-1,5-lactone

135450
type: SpeciesReference
stoichiometry: 1.0
species: 644846

644846
type: Species
notes: FORMULA: C6H10O10P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 6-Phospho-D-gluconate

135462
type: SpeciesReference
stoichiometry: 1.0
species: 645712

662069
type: LocalParameter
units: 032971
value: 500.0

662068
type: LocalParameter
value: 0.0

662066
type: LocalParameter
units: 033007
value: 1000.0

662065
type: LocalParameter
units: 033007
value: 0.0

648742
type: Reaction
kinetic law: 093559
product: 093547
reactant: 093535
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 10-Formyltetrahydrofolate mitochondrial transport via diffusion

658204
type: LocalParameter
units: 032971
value: 0.0

658203
type: LocalParameter
value: 0.0

658202
type: LocalParameter
units: 033007
value: 1000.0

658201
type: LocalParameter
units: 033007
value: -1000.0

093547
type: SpeciesReference
stoichiometry: 1.0
species: 644644

644644
type: Species
notes: FORMULA: C20H21N7O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 10-Formyltetrahydrofolate

093535
type: SpeciesReference
stoichiometry: 1.0
species: 644641

644641
type: Species
notes: FORMULA: C20H21N7O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 10-Formyltetrahydrofolate

646498
type: Species
notes: FORMULA: C41H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: timnodonyl coenzyme A

650718
type: Reaction
reactant: 137538
product: 137587
reactant: 137574
kinetic law: 137635
name: Beta oxidation of long chain fatty acid
reactant: 137550
product: 137623
reactant: 137562
reversible: false
fast: false
product: 137611
reactant: 137526
notes: GENE_ASSOCIATION: (35.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
product: 137599

137538
type: SpeciesReference
stoichiometry: 10.0
species: 645224

137587
type: SpeciesReference
stoichiometry: 11.0
species: 644941

644941
type: Species
notes: FORMULA: C23H34N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Acetyl-CoA

137574
type: SpeciesReference
stoichiometry: 10.0
species: 645998

662252
type: LocalParameter
units: 032971
value: 500.0

662250
type: LocalParameter
value: 0.0

662248
type: LocalParameter
units: 033007
value: 1000.0

662247
type: LocalParameter
units: 033007
value: 0.0

137550
type: SpeciesReference
stoichiometry: 4.0
species: 645512

645512
type: Species
notes: FORMULA: C27H31N9O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Flavin adenine dinucleotide oxidized

137623
type: SpeciesReference
stoichiometry: 10.0
species: 646006

137562
type: SpeciesReference
stoichiometry: 10.0
species: 645704

645704
type: Species
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: H2O

137611
type: SpeciesReference
stoichiometry: 10.0
species: 645716

137526
type: SpeciesReference
stoichiometry: 1.0
species: 645128

645128
type: Species
notes: FORMULA: C43H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: cervonyl coenzyme A

137599
type: SpeciesReference
stoichiometry: 4.0
species: 645518

645518
type: Species
notes: FORMULA: C27H33N9O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Flavin adenine dinucleotide reduced

647731
type: Reaction
kinetic law: 057580
product: 057568
reactant: 057556
notes: GENE_ASSOCIATION: (5236.1) or (55276.1) GENE_LIST: 5236.1 55276.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: phosphoglucomutase

654456
type: LocalParameter
units: 032971
value: 0.0

654454
type: LocalParameter
value: 0.0

654452
type: LocalParameter
units: 033007
value: 1000.0

654450
type: LocalParameter
units: 033007
value: -1000.0

057568
type: SpeciesReference
stoichiometry: 1.0
species: 645563

645563
type: Species
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Glucose 6-phosphate

057556
type: SpeciesReference
stoichiometry: 1.0
species: 645559

648031
type: Reaction
kinetic law: 069505
product: 069493
reactant: 069481
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: acetaldehyde peroxisomal diffusion

655903
type: LocalParameter
units: 032971
value: 0.0

655901
type: LocalParameter
value: 0.0

655899
type: LocalParameter
units: 033007
value: 1000.0

655897
type: LocalParameter
units: 033007
value: -1000.0

069493
type: SpeciesReference
stoichiometry: 1.0
species: 644933

644933
type: Species
notes: FORMULA: C2H4O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Acetaldehyde

069481
type: SpeciesReference
stoichiometry: 1.0
species: 644938

644938
type: Species
notes: FORMULA: C2H4O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Acetaldehyde

647944
type: Reaction
reactant: 066078
fast: false
notes: GENE_ASSOCIATION: (686.1) GENE_LIST: 686.1 SUBSYSTEM: Biotin Metabolism
reactant: 066066
kinetic law: 066114
name: biotinidase (biotin), extracellular
reversible: false
product: 066090
product: 066102

066078
type: SpeciesReference
stoichiometry: 1.0
species: 645701

066066
type: SpeciesReference
stoichiometry: 1.0
species: 645118

645118
type: Species
notes: FORMULA: C16H28N4O4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Biocytin

655450
type: LocalParameter
units: 032971
value: 500.0

655448
type: LocalParameter
value: 0.0

655446
type: LocalParameter
units: 033007
value: 1000.0

655444
type: LocalParameter
units: 033007
value: 0.0

066090
type: SpeciesReference
stoichiometry: 1.0
species: 645121

645121
type: Species
notes: FORMULA: C10H15N2O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Biotin

066102
type: SpeciesReference
stoichiometry: 1.0
species: 645917

645917
type: Species
notes: FORMULA: C6H15N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Lysine

649957
type: Reaction
kinetic law: 118444
product: 118432
reactant: 118420
fast: false
reversible: true
name: Guanosine exchange

660438
type: LocalParameter
units: 032971
value: 0.0

660437
type: LocalParameter
value: 0.0

660435
type: LocalParameter
units: 033007
value: 1000.0

660434
type: LocalParameter
units: 033007
value: -1000.0

118432
type: SpeciesReference
stoichiometry: 1.0
species: 647037

647037
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: s2l2fn2m2masn_b

118420
type: SpeciesReference
stoichiometry: 1.0
species: 645664

645172
type: Species
notes: FORMULA: C24H39O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Cholate

646495
type: Species
notes: FORMULA: C41H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: timnodonyl coenzyme A

645940
type: Species
notes: FORMULA: CH4O1
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: Methanol

645362
type: Species
notes: FORMULA: C6H6O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Dehydroascorbate

646225
type: Species
notes: FORMULA: HO7P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: Diphosphate

649321
type: Reaction
reactant: 105844
reversible: false
product: 105868
product: 105880
reactant: 105856
name: 3-Dehydrosphinganine reductase
fast: false
kinetic law: 105892
notes: GENE_ASSOCIATION: (2531.1) GENE_LIST: 2531.1 SUBSYSTEM: Sphingolipid Metabolism
reactant: 105832

105844
type: SpeciesReference
stoichiometry: 1.0
species: 645712

105868
type: SpeciesReference
stoichiometry: 1.0
species: 646010

105880
type: SpeciesReference
stoichiometry: 1.0
species: 646345

646345
type: Species
notes: FORMULA: C18H40NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sphinganine

105856
type: SpeciesReference
stoichiometry: 1.0
species: 646018

659282
type: LocalParameter
units: 032971
value: 500.0

659281
type: LocalParameter
value: 0.0

659280
type: LocalParameter
units: 033007
value: 1000.0

659278
type: LocalParameter
units: 033007
value: 0.0

105832
type: SpeciesReference
stoichiometry: 1.0
species: 644722

644722
type: Species
notes: FORMULA: C18H38NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Dehydrosphinganine

647968
type: Reaction
kinetic law: 067046
product: 067033
reactant: 067020
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion

655562
type: LocalParameter
units: 032971
value: 0.0

655560
type: LocalParameter
value: 0.0

655558
type: LocalParameter
units: 033007
value: 1000.0

655556
type: LocalParameter
units: 033007
value: -1000.0

067033
type: SpeciesReference
stoichiometry: 1.0
species: 644986

644986
type: Species
notes: FORMULA: C22H35O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: adrenic acid

067020
type: SpeciesReference
stoichiometry: 1.0
species: 644987

644987
type: Species
notes: FORMULA: C22H35O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: adrenic acid

648502
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (6579.1) or (10599.1) GENE_LIST: 10599.1 6579.1 SUBSYSTEM: Transport, Extracellular
product: 085758
name: cholate transport via bicarbonate countertransport
product: 085746
fast: false
reactant: 085721
kinetic law: 085770
reactant: 085734

085758
type: SpeciesReference
stoichiometry: 1.0
species: 645731

645731
type: Species
notes: FORMULA: CHO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Bicarbonate

085746
type: SpeciesReference
stoichiometry: 1.0
species: 645170

645170
type: Species
notes: FORMULA: C24H39O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Cholate

085721
type: SpeciesReference
stoichiometry: 1.0
species: 645172

657558
type: LocalParameter
units: 032971
value: 0.0

657557
type: LocalParameter
value: 0.0

657556
type: LocalParameter
units: 033007
value: 1000.0

657555
type: LocalParameter
units: 033007
value: -1000.0

085734
type: SpeciesReference
stoichiometry: 1.0
species: 645730

645730
type: Species
notes: FORMULA: CHO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Bicarbonate

648004
type: Reaction
fast: false
reversible: false
notes: GENE_ASSOCIATION: (6817.4) or (6817.1) or (6817.3) or (6817.2) or (6817.5) GENE_LIST: 6817.1 6817.2 6817.3 6817.4 6817.5 SUBSYSTEM: Tyrosine metabolism
product: 068373
product: 068385
reactant: 068337
reactant: 068349
product: 068361
kinetic law: 068397
name: Triiodothyronine Sulfotransferase

068373
type: SpeciesReference
stoichiometry: 1.0
species: 646148

646148
type: Species
notes: FORMULA: C10H11N5O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Adenosine 3',5'-bisphosphate

068385
type: SpeciesReference
stoichiometry: 1.0
species: 646510

646510
type: Species
notes: FORMULA: C15H11I3NO7S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Triiodothyronine sulfate

068337
type: SpeciesReference
stoichiometry: 1.0
species: 646150

068349
type: SpeciesReference
stoichiometry: 1.0
species: 646508

646508
type: Species
notes: FORMULA: C15H12I3NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Triiodothyronine

068361
type: SpeciesReference
stoichiometry: 1.0
species: 645712

655783
type: LocalParameter
units: 032971
value: 500.0

655781
type: LocalParameter
value: 0.0

655779
type: LocalParameter
units: 033007
value: 1000.0

655777
type: LocalParameter
units: 033007
value: 0.0

648217
type: Reaction
fast: false
reversible: false
reactant: 075607
kinetic law: 075655
product: 075643
reactant: 075619
product: 075631
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) GENE_LIST: 126129.1 1374.1 1375.1 1375.2 1375.3 1375.4 SUBSYSTEM: Carnitine shuttle
name: carnitine O-palmitoyltransferase

075607
type: SpeciesReference
stoichiometry: 1.0
species: 645244

656602
type: LocalParameter
units: 032971
value: 500.0

656600
type: LocalParameter
value: 0.0

656598
type: LocalParameter
units: 033007
value: 1000.0

656596
type: LocalParameter
units: 033007
value: 0.0

075643
type: SpeciesReference
stoichiometry: 1.0
species: 645743

645743
type: Species
notes: FORMULA: C23H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hexadecenoyl carnitine

075619
type: SpeciesReference
stoichiometry: 1.0
species: 645746

645746
type: Species
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hexadecenoyl-CoA (n-C16:1CoA)

075631
type: SpeciesReference
stoichiometry: 1.0
species: 645223

649180
type: Reaction
name: methylmalonate-semialdehyde dehydrogenase (malonic semialdehyde), mitochondrial
fast: false
reactant: 103010
reactant: 103022
product: 103058
product: 103034
kinetic law: 103070
reversible: false
product: 103046
notes: GENE_ASSOCIATION: (4329.1) GENE_LIST: 4329.1 SUBSYSTEM: Propanoate Metabolism
reactant: 102998

103010
type: SpeciesReference
stoichiometry: 1.0
species: 645983

645983
type: Species
notes: FORMULA: C3H3O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Malonate semialdehyde

103022
type: SpeciesReference
stoichiometry: 1.0
species: 645998

103058
type: SpeciesReference
stoichiometry: 1.0
species: 646006

103034
type: SpeciesReference
stoichiometry: 1.0
species: 644941

659032
type: LocalParameter
units: 032971
value: 500.0

659031
type: LocalParameter
value: 0.0

659030
type: LocalParameter
units: 033007
value: 1000.0

659029
type: LocalParameter
units: 033007
value: 0.0

103046
type: SpeciesReference
stoichiometry: 1.0
species: 645215

102998
type: SpeciesReference
stoichiometry: 1.0
species: 645224

649021
type: Reaction
name: glycerol kinase
kinetic law: 100128
product: 100092
reversible: false
product: 100104
reactant: 100079
fast: false
product: 100116
reactant: 100067
notes: GENE_ASSOCIATION: (2710.2) or (2712.1) or (2710.1) or (2713.1) GENE_LIST: 2710.1 2710.2 2712.1 2713.1 SUBSYSTEM: Glycerophospholipid Metabolism

658763
type: LocalParameter
units: 032971
value: 500.0

658762
type: LocalParameter
value: 0.0

658761
type: LocalParameter
units: 033007
value: 1000.0

658760
type: LocalParameter
units: 033007
value: 0.0

100092
type: SpeciesReference
stoichiometry: 1.0
species: 644974

100104
type: SpeciesReference
stoichiometry: 1.0
species: 645640

645640
type: Species
notes: FORMULA: C3H7O6P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Glycerol 3-phosphate

100079
type: SpeciesReference
stoichiometry: 1.0
species: 645643

100116
type: SpeciesReference
stoichiometry: 1.0
species: 645712

100067
type: SpeciesReference
stoichiometry: 1.0
species: 645088

645446
type: Species
notes: FORMULA: C9H11N2O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dUTP

646169
type: Species
notes: FORMULA: C5H12NO4PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: phosphatidylethanolamine (homo sapiens)

650162
type: Reaction
kinetic law: 122625
product: 122613
reactant: 122601
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport

660865
type: LocalParameter
units: 032971
value: 0.0

660863
type: LocalParameter
value: 0.0

660862
type: LocalParameter
units: 033007
value: 1000.0

660860
type: LocalParameter
units: 033007
value: -1000.0

122613
type: SpeciesReference
stoichiometry: 1.0
species: 646057

646057
type: Species
notes: FORMULA: C45H76N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: nervonyl coenzyme A

122601
type: SpeciesReference
stoichiometry: 1.0
species: 646055

646055
type: Species
notes: FORMULA: C45H76N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: nervonyl coenzyme A

650228
type: Reaction
kinetic law: 123809
product: 123797
reactant: 123785
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: Thiocyanate transport via diffusion (mitochondrial)

660986
type: LocalParameter
units: 032971
value: 500.0

660984
type: LocalParameter
value: 0.0

660983
type: LocalParameter
units: 033007
value: 1000.0

660981
type: LocalParameter
units: 033007
value: 0.0

123797
type: SpeciesReference
stoichiometry: 1.0
species: 646415

646415
type: Species
notes: FORMULA: CNS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Thiocyanate

123785
type: SpeciesReference
stoichiometry: 1.0
species: 646418

646418
type: Species
notes: FORMULA: CNS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Thiocyanate

648355
type: Reaction
kinetic law: 079962
product: 079950
reactant: 079938
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: Dopamine 3-0-sulfate transport (diffusion)

657042
type: LocalParameter
units: 032971
value: 500.0

657041
type: LocalParameter
value: 0.0

657040
type: LocalParameter
units: 033007
value: 1000.0

657038
type: LocalParameter
units: 033007
value: 0.0

079950
type: SpeciesReference
stoichiometry: 1.0
species: 645413

645413
type: Species
notes: FORMULA: C8H11NO5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Dopamine 3-O-sulfate

079938
type: SpeciesReference
stoichiometry: 1.0
species: 645412

645533
type: Species
notes: FORMULA: Fe
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Fe3+

647522
type: Reaction
kinetic law: 049093
product: 049081
reactant: 049069
fast: false
reversible: true
name: R total 3 position exchange

653436
type: LocalParameter
units: 032971
value: 0.0

653434
type: LocalParameter
value: 0.0

653432
type: LocalParameter
units: 033007
value: 1000.0

653430
type: LocalParameter
units: 033007
value: -1000.0

049081
type: SpeciesReference
stoichiometry: 1.0
species: 646808

646808
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ala_DASH_D_b

049069
type: SpeciesReference
stoichiometry: 1.0
species: 644896

644896
type: Species
notes: FORMULA: CO2FULLR3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: R total 3 position

645443
type: Species
notes: FORMULA: C9H12N2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Deoxyuridine

649609
type: Reaction
name: saccharopine dehydrogenase (NAD, L-glutamate forming), mitochondrial
product: 111742
fast: false
product: 111754
kinetic law: 111790
reactant: 111718
product: 111778
product: 111766
notes: GENE_ASSOCIATION: (10157.1) GENE_LIST: 10157.1 SUBSYSTEM: Lysine Metabolism
reactant: 111706
reactant: 111730
reversible: false

111742
type: SpeciesReference
stoichiometry: 1.0
species: 644869

111754
type: SpeciesReference
stoichiometry: 1.0
species: 645616

659804
type: LocalParameter
units: 032971
value: 500.0

659803
type: LocalParameter
value: 0.0

659801
type: LocalParameter
units: 033007
value: 1000.0

659800
type: LocalParameter
units: 033007
value: 0.0

111718
type: SpeciesReference
stoichiometry: 1.0
species: 646013

646013
type: Species
notes: FORMULA: C21H25N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Nicotinamide adenine dinucleotide phosphate

111778
type: SpeciesReference
stoichiometry: 1.0
species: 646019

646019
type: Species
notes: FORMULA: C21H26N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Nicotinamide adenine dinucleotide phosphate - reduced

111766
type: SpeciesReference
stoichiometry: 1.0
species: 645716

111706
type: SpeciesReference
stoichiometry: 1.0
species: 645704

111730
type: SpeciesReference
stoichiometry: 1.0
species: 646322

646322
type: Species
notes: FORMULA: C11H19N2O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Saccharopine

647455
type: Reaction
kinetic law: 046507
product: 046495
reactant: 046483
fast: false
reversible: true
name: Pyridoxamine exchange

653007
type: LocalParameter
units: 032971
value: 0.0

653004
type: LocalParameter
value: 0.0

653001
type: LocalParameter
units: 033007
value: 1000.0

652998
type: LocalParameter
units: 033007
value: -1000.0

046495
type: SpeciesReference
stoichiometry: 1.0
species: 646795

646795
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ach_b

046483
type: SpeciesReference
stoichiometry: 1.0
species: 646271

646271
type: Species
notes: FORMULA: C8H13N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Pyridoxamine

645959
type: Species
notes: FORMULA: C6H11O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: (R)-Mevalonate

647308
type: Reaction
product: 040874
kinetic law: 040886
reactant: 040850
product: 040862
name: 4-aminobutyrate transaminase, reversible (mitochondrial)
fast: false
reactant: 040838
reversible: true
notes: GENE_ASSOCIATION: (18.1) or (18.2) GENE_LIST: 18.1 18.2 SUBSYSTEM: Glutamate metabolism

040874
type: SpeciesReference
stoichiometry: 1.0
species: 646394

646394
type: Species
notes: FORMULA: C4H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Succinic semialdehyde

652033
type: LocalParameter
units: 032971
value: 0.0

652030
type: LocalParameter
value: 0.0

652027
type: LocalParameter
units: 033007
value: 1000.0

652024
type: LocalParameter
units: 033007
value: -1000.0

040850
type: SpeciesReference
stoichiometry: 1.0
species: 645011

040862
type: SpeciesReference
stoichiometry: 1.0
species: 645616

040838
type: SpeciesReference
stoichiometry: 1.0
species: 644764

644764
type: Species
notes: FORMULA: C4H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 4-Aminobutanoate

647377
type: Reaction
reversible: true
name: 3-Mercaptolactate:NAD+ oxidoreductase
reactant: 043483
fast: false
product: 043519
kinetic law: 043531
reactant: 043470
product: 043507
product: 043495
notes: GENE_ASSOCIATION: (92483.1) or (3945.1 and 3939.1) or (55293.1) or (3948.2) or (3948.1) or (3945.1) or (160287.1) or (3939.1) GENE_LIST: 160287.1 3939.1 3945.1 3948.1 3948.2 55293.1 92483.1 SUBSYSTEM: Cysteine Metabolism

043483
type: SpeciesReference
stoichiometry: 1.0
species: 645995

043519
type: SpeciesReference
stoichiometry: 1.0
species: 646004

652491
type: LocalParameter
units: 032971
value: 0.0

652488
type: LocalParameter
value: 0.0

652485
type: LocalParameter
units: 033007
value: 1000.0

652482
type: LocalParameter
units: 033007
value: -1000.0

043470
type: SpeciesReference
stoichiometry: 1.0
species: 645944

645944
type: Species
notes: FORMULA: C3H5O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Mercaptolactate

043507
type: SpeciesReference
stoichiometry: 1.0
species: 645949

645949
type: Species
notes: FORMULA: C3H3O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Mercaptopyruvate

043495
type: SpeciesReference
stoichiometry: 1.0
species: 645712

647288
type: Reaction
reactant: 040079
reactant: 040091
product: 040115
fast: false
reversible: true
product: 040103
kinetic law: 040127
name: carnitine O-aceyltransferase, mitochondrial
notes: GENE_ASSOCIATION: (1384.1) GENE_LIST: 1384.1 SUBSYSTEM: Fatty Acid Metabolism

040079
type: SpeciesReference
stoichiometry: 1.0
species: 644963

644963
type: Species
notes: FORMULA: C9H17NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: O-Acetylcarnitine

040091
type: SpeciesReference
stoichiometry: 1.0
species: 645224

040115
type: SpeciesReference
stoichiometry: 1.0
species: 645247

040103
type: SpeciesReference
stoichiometry: 1.0
species: 644941

651909
type: LocalParameter
units: 032971
value: 0.0

651906
type: LocalParameter
value: 0.0

651903
type: LocalParameter
units: 033007
value: 1000.0

651900
type: LocalParameter
units: 033007
value: -1000.0

648070
type: Reaction
reversible: true
product: 071228
reactant: 071192
reactant: 071204
product: 071240
product: 071252
notes: GENE_ASSOCIATION: (222.1) or (220.1) or (221.1) or (218.1) GENE_LIST: 218.1 220.1 221.1 222.1 SUBSYSTEM: Tyrosine metabolism
kinetic law: 071264
name: 4-Hydroxyphenylacetaldehyde:NADP+ oxidoreductase
reactant: 071216
fast: false

071228
type: SpeciesReference
stoichiometry: 1.0
species: 644774

644774
type: Species
notes: FORMULA: C8H7O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4-Hydroxyphenylacetate

071192
type: SpeciesReference
stoichiometry: 1.0
species: 644773

644773
type: Species
notes: FORMULA: C8H8O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4-Hydroxyphenylacetaldehyde

071204
type: SpeciesReference
stoichiometry: 1.0
species: 645700

071240
type: SpeciesReference
stoichiometry: 2.0
species: 645712

071252
type: SpeciesReference
stoichiometry: 1.0
species: 646018

656085
type: LocalParameter
units: 032971
value: 0.0

656083
type: LocalParameter
value: 0.0

656081
type: LocalParameter
units: 033007
value: 1000.0

656079
type: LocalParameter
units: 033007
value: -1000.0

071216
type: SpeciesReference
stoichiometry: 1.0
species: 646010

645206
type: Species
notes: FORMULA: C9H12N3O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: CMP

649963
type: Reaction
kinetic law: 118540
product: 118528
reactant: 118516
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: false
name: retinoyl glucuronide efflux from ER

660449
type: LocalParameter
units: 032971
value: 500.0

660448
type: LocalParameter
value: 0.0

660446
type: LocalParameter
units: 033007
value: 1000.0

660445
type: LocalParameter
units: 033007
value: 0.0

118528
type: SpeciesReference
stoichiometry: 1.0
species: 646306

646306
type: Species
notes: FORMULA: C26H35O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: retinoyl glucuronide

118516
type: SpeciesReference
stoichiometry: 1.0
species: 646309

646309
type: Species
notes: FORMULA: C26H35O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: retinoyl glucuronide

647068
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tethex3_b

648901
type: Reaction
name: cytidylate kinase (CMP,dCTP),nuclear
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
product: 097343
reactant: 097331
reactant: 097319
product: 097356
fast: false
kinetic law: 097368
reversible: true

097343
type: SpeciesReference
stoichiometry: 1.0
species: 645151

097331
type: SpeciesReference
stoichiometry: 1.0
species: 645317

645317
type: Species
notes: FORMULA: C9H12N3O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dCTP

097319
type: SpeciesReference
stoichiometry: 1.0
species: 645209

097356
type: SpeciesReference
stoichiometry: 1.0
species: 645298

645298
type: Species
notes: FORMULA: C9H12N3O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dCDP

658503
type: LocalParameter
units: 032971
value: 0.0

658502
type: LocalParameter
value: 0.0

658501
type: LocalParameter
units: 033007
value: 1000.0

658500
type: LocalParameter
units: 033007
value: -1000.0

645478
type: Species
notes: FORMULA: C18H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: elaidic acid

645863
type: Species
notes: FORMULA: C45H78N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: lignocericyl coenzyme A

650742
type: Reaction
kinetic law: 138370
reactant: 138322
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
reactant: 138334
product: 138358
fast: false
reversible: true
product: 138346
name: cytidylate kinase (dCMP)

662319
type: LocalParameter
units: 032971
value: 0.0

662317
type: LocalParameter
value: 0.0

662315
type: LocalParameter
units: 033007
value: 1000.0

662314
type: LocalParameter
units: 033007
value: -1000.0

138322
type: SpeciesReference
stoichiometry: 1.0
species: 645254

138334
type: SpeciesReference
stoichiometry: 1.0
species: 645301

645301
type: Species
notes: FORMULA: C9H12N3O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dCMP

138358
type: SpeciesReference
stoichiometry: 1.0
species: 645295

645295
type: Species
notes: FORMULA: C9H12N3O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dCDP

138346
type: SpeciesReference
stoichiometry: 1.0
species: 645148

645388
type: Species
notes: FORMULA: C6H9O6PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2,3-diketo-5-methylthio-1-phosphopentane

650711
type: Reaction
product: 137337
product: 137351
name: Fatty acid omega-hydroxylase
reactant: 137287
reactant: 137275
kinetic law: 137364
reversible: false
notes: GENE_ASSOCIATION: (1579.1) GENE_LIST: 1579.1 SUBSYSTEM: CYP Metabolism
product: 137324
reactant: 137311
reactant: 137299
fast: false

137337
type: SpeciesReference
stoichiometry: 1.0
species: 646010

137351
type: SpeciesReference
stoichiometry: 1.0
species: 646598

646598
type: Species
notes: FORMULA: C14H27O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: omega hydroxy tetradecanoate (n-C14:0)

137287
type: SpeciesReference
stoichiometry: 1.0
species: 646018

137275
type: SpeciesReference
stoichiometry: 1.0
species: 645712

662234
type: LocalParameter
units: 032971
value: 500.0

662233
type: LocalParameter
value: 0.0

662231
type: LocalParameter
units: 033007
value: 1000.0

662230
type: LocalParameter
units: 033007
value: 0.0

137324
type: SpeciesReference
stoichiometry: 1.0
species: 645700

137311
type: SpeciesReference
stoichiometry: 1.0
species: 646520

646520
type: Species
notes: FORMULA: C14H27O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetradecanoate (n-C14:0)

137299
type: SpeciesReference
stoichiometry: 1.0
species: 646060

650459
type: Reaction
product: 129725
reversible: false
reactant: 129677
reactant: 129689
reactant: 129701
name: aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
notes: GENE_ASSOCIATION: (1109.1) GENE_LIST: 1109.1 SUBSYSTEM: Bile Acid Biosynthesis
product: 129713
fast: false
kinetic law: 129738

129725
type: SpeciesReference
stoichiometry: 1.0
species: 646648

646648
type: Species
notes: FORMULA: C27H48O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane

129677
type: SpeciesReference
stoichiometry: 1.0
species: 645712

129689
type: SpeciesReference
stoichiometry: 1.0
species: 646004

129701
type: SpeciesReference
stoichiometry: 1.0
species: 646627

646627
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

129713
type: SpeciesReference
stoichiometry: 1.0
species: 645995

661541
type: LocalParameter
units: 032971
value: 500.0

661540
type: LocalParameter
value: 0.0

661538
type: LocalParameter
units: 033007
value: 1000.0

661537
type: LocalParameter
units: 033007
value: 0.0

646040
type: Species
notes: FORMULA: C11H14N2O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: NMN

648326
type: Reaction
reactant: 078827
product: 078863
product: 078851
product: 078887
product: 078875
reactant: 078815
name: Beta oxidation of fatty acid
reactant: 078779
reversible: false
product: 078839
reactant: 078803
reactant: 078791
notes: GENE_ASSOCIATION: (34.1) or (35.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
fast: false
kinetic law: 078899

078827
type: SpeciesReference
stoichiometry: 5.0
species: 645998

078863
type: SpeciesReference
stoichiometry: 5.0
species: 645716

078851
type: SpeciesReference
stoichiometry: 3.0
species: 645518

078887
type: SpeciesReference
stoichiometry: 1.0
species: 646076

646076
type: Species
notes: FORMULA: C29H46N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Octanoyl-CoA (n-C8:0CoA)

078875
type: SpeciesReference
stoichiometry: 5.0
species: 646006

078815
type: SpeciesReference
stoichiometry: 1.0
species: 645884

645884
type: Species
notes: FORMULA: C39H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: linoleic coenzyme A

078779
type: SpeciesReference
stoichiometry: 5.0
species: 645224

078839
type: SpeciesReference
stoichiometry: 5.0
species: 644941

078803
type: SpeciesReference
stoichiometry: 5.0
species: 645704

078791
type: SpeciesReference
stoichiometry: 3.0
species: 645512

656945
type: LocalParameter
units: 032971
value: 500.0

656944
type: LocalParameter
value: 0.0

656921
type: LocalParameter
units: 033007
value: 1000.0

656919
type: LocalParameter
units: 033007
value: 0.0

648361
type: Reaction
kinetic law: 080193
product: 080181
reactant: 080169
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: choline transport via diffusion (cytosol to mitochondria)

657059
type: LocalParameter
units: 032971
value: 0.0

657058
type: LocalParameter
value: 0.0

657057
type: LocalParameter
units: 033007
value: 1000.0

657056
type: LocalParameter
units: 033007
value: -1000.0

080181
type: SpeciesReference
stoichiometry: 1.0
species: 645166

645166
type: Species
notes: FORMULA: C5H14NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Choline

080169
type: SpeciesReference
stoichiometry: 1.0
species: 645163

645163
type: Species
notes: FORMULA: C5H14NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Choline

645190
type: Species
notes: FORMULA: C6H5O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Citrate

645371
type: Species
notes: FORMULA: C19H19N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 7,8-Dihydrofolate

648286
type: Reaction
kinetic law: 077553
product: 077541
reactant: 077529
fast: false
reversible: true
name: Glycerol exchange

656813
type: LocalParameter
units: 032971
value: 0.0

656812
type: LocalParameter
value: 0.0

656811
type: LocalParameter
units: 033007
value: 1000.0

656810
type: LocalParameter
units: 033007
value: -1000.0

077541
type: SpeciesReference
stoichiometry: 1.0
species: 646890

646890
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: fe3_b

077529
type: SpeciesReference
stoichiometry: 1.0
species: 645644

645644
type: Species
notes: FORMULA: C3H8O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Glycerol

647974
type: Reaction
kinetic law: 067275
product: 067263
reactant: 067251
fast: false
reversible: true
name: methanol exchange

655590
type: LocalParameter
units: 032971
value: 0.0

655588
type: LocalParameter
value: 0.0

655586
type: LocalParameter
units: 033007
value: 1000.0

655584
type: LocalParameter
units: 033007
value: -1000.0

067263
type: SpeciesReference
stoichiometry: 1.0
species: 646860

646860
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: debrisoquine_b

067251
type: SpeciesReference
stoichiometry: 1.0
species: 645938

650695
type: Reaction
notes: GENE_ASSOCIATION: (8639.1) GENE_LIST: 8639.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 136816
reactant: 136780
fast: false
product: 136828
name: Aminoacetone:oxygen oxidoreductase(deaminating)(flavin-containing)
reactant: 136768
kinetic law: 136840
reversible: false
reactant: 136792
product: 136804

136816
type: SpeciesReference
stoichiometry: 1.0
species: 645985

136780
type: SpeciesReference
stoichiometry: 1.0
species: 645700

136828
type: SpeciesReference
stoichiometry: 1.0
species: 646027

136768
type: SpeciesReference
stoichiometry: 1.0
species: 644917

644917
type: Species
notes: FORMULA: C3H8NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Aminoacetone

662190
type: LocalParameter
units: 032971
value: 500.0

662189
type: LocalParameter
value: 0.0

662187
type: LocalParameter
units: 033007
value: 1000.0

662186
type: LocalParameter
units: 033007
value: 0.0

136792
type: SpeciesReference
stoichiometry: 1.0
species: 646060

136804
type: SpeciesReference
stoichiometry: 1.0
species: 645692

645920
type: Species
notes: FORMULA: C6H15N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: L-Lysine

650306
type: Reaction
reversible: true
product: 125364
reactant: 125316
notes: GENE_ASSOCIATION: (9162.1) or (1607.1) or (8525.2) or (160851.1) or (1608.1) or (1607.2) or (8525.1) or (8527.1) or (1606.1) or (160851.2) or (8526.1) or (8525.3) or (1607.1) or (8527.2) or (1609.1) GENE_LIST: 1606.1 1607.1 1607.2 1608.1 160851.1 160851.2 1609.1 8525.1 8525.2 8525.3 8526.1 8527.1 8527.2 9162.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
name: Diacylglycerol phosphate kinase (homo sapiens)
product: 125352
product: 125340
reactant: 125328
kinetic law: 125376

125364
type: SpeciesReference
stoichiometry: 1.0
species: 646120

646120
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: phosphatidic acid (homo sapiens)

125316
type: SpeciesReference
stoichiometry: 1.0
species: 645088

125352
type: SpeciesReference
stoichiometry: 1.0
species: 645712

125340
type: SpeciesReference
stoichiometry: 1.0
species: 644974

125328
type: SpeciesReference
stoichiometry: 1.0
species: 645281

645281
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: diacylglycerol (homo sapiens)

661129
type: LocalParameter
units: 032971
value: 0.0

661127
type: LocalParameter
value: 0.0

661126
type: LocalParameter
units: 033007
value: 1000.0

661124
type: LocalParameter
units: 033007
value: -1000.0

648412
type: Reaction
fast: false
kinetic law: 082156
reactant: 082118
product: 082143
reactant: 082106
product: 082131
reversible: true
notes: GENE_ASSOCIATION: (1468.1) GENE_LIST: 1468.1 SUBSYSTEM: Transport, Mitochondrial
name: fumarate transport, mitochondrial

657315
type: LocalParameter
units: 032971
value: 0.0

657314
type: LocalParameter
value: 0.0

657313
type: LocalParameter
units: 033007
value: 1000.0

657312
type: LocalParameter
units: 033007
value: -1000.0

082118
type: SpeciesReference
stoichiometry: 1.0
species: 646196

082143
type: SpeciesReference
stoichiometry: 1.0
species: 646193

082106
type: SpeciesReference
stoichiometry: 1.0
species: 645556

645556
type: Species
notes: FORMULA: C4H2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Fumarate

082131
type: SpeciesReference
stoichiometry: 1.0
species: 645557

645557
type: Species
notes: FORMULA: C4H2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Fumarate

650763
type: Reaction
reactant: 139059
kinetic law: 139108
notes: GENE_ASSOCIATION: (271.2) or (270.1) or (271.1) or (272.1) or (271.3) GENE_LIST: 270.1 271.1 271.2 271.3 272.1 SUBSYSTEM: Nucleotides
fast: false
reactant: 139047
reactant: 139071
product: 139083
reversible: false
name: Adenosine monophosphate deaminase
product: 139096

139059
type: SpeciesReference
stoichiometry: 1.0
species: 645700

662383
type: LocalParameter
units: 032971
value: 500.0

662381
type: LocalParameter
value: 0.0

662379
type: LocalParameter
units: 033007
value: 1000.0

662378
type: LocalParameter
units: 033007
value: 0.0

139047
type: SpeciesReference
stoichiometry: 1.0
species: 645037

645037
type: Species
notes: FORMULA: C10H12N5O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: AMP

139071
type: SpeciesReference
stoichiometry: 1.0
species: 645712

139083
type: SpeciesReference
stoichiometry: 1.0
species: 645814

645814
type: Species
notes: FORMULA: C10H11N4O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: IMP

139096
type: SpeciesReference
stoichiometry: 1.0
species: 646027

644749
type: Species
notes: FORMULA: C3H4O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Phospho-D-glycerate

646777
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 5homeprazole_b

645439
type: Species
notes: FORMULA: C9H11N2O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dUMP

648712
type: Reaction
kinetic law: 092854
product: 092842
reactant: 092830
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: false
name: FADH2 transporter, endoplasmic reticulum

658149
type: LocalParameter
units: 032971
value: 500.0

658148
type: LocalParameter
value: 0.0

658147
type: LocalParameter
units: 033007
value: 1000.0

658146
type: LocalParameter
units: 033007
value: 0.0

092842
type: SpeciesReference
stoichiometry: 1.0
species: 645520

092830
type: SpeciesReference
stoichiometry: 1.0
species: 645517

645517
type: Species
notes: FORMULA: C27H33N9O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Flavin adenine dinucleotide reduced

648757
type: Reaction
kinetic law: 093995
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
name: cytidylate kinase (CMP),nuclear
reactant: 093947
reactant: 093959
product: 093971
reversible: true
fast: false
product: 093983

658237
type: LocalParameter
units: 032971
value: 0.0

658236
type: LocalParameter
value: 0.0

658235
type: LocalParameter
units: 033007
value: 1000.0

658234
type: LocalParameter
units: 033007
value: -1000.0

093947
type: SpeciesReference
stoichiometry: 1.0
species: 645209

093959
type: SpeciesReference
stoichiometry: 1.0
species: 645679

645679
type: Species
notes: FORMULA: C10H12N5O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: GTP

093971
type: SpeciesReference
stoichiometry: 1.0
species: 645151

093983
type: SpeciesReference
stoichiometry: 1.0
species: 645587

645587
type: Species
notes: FORMULA: C10H12N5O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: GDP

648247
type: Reaction
kinetic law: 076601
notes: GENE_ASSOCIATION: (5019.1) or (64064.1) GENE_LIST: 5019.1 64064.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
reversible: true
name: 3-oxoacid CoA-transferase
reactant: 076565
product: 076589
reactant: 076552
product: 076577
fast: false

656712
type: LocalParameter
units: 032971
value: 0.0

656710
type: LocalParameter
value: 0.0

656708
type: LocalParameter
units: 033007
value: 1000.0

656706
type: LocalParameter
units: 033007
value: -1000.0

076565
type: SpeciesReference
stoichiometry: 1.0
species: 646391

646391
type: Species
notes: FORMULA: C25H35N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Succinyl-CoA

076589
type: SpeciesReference
stoichiometry: 1.0
species: 646390

646390
type: Species
notes: FORMULA: C4H4O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Succinate

076552
type: SpeciesReference
stoichiometry: 1.0
species: 644930

644930
type: Species
notes: FORMULA: C4H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Acetoacetate

076577
type: SpeciesReference
stoichiometry: 1.0
species: 644915

644915
type: Species
notes: FORMULA: C25H36N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Acetoacetyl-CoA

646864
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: dhdascb_b

645526
type: Species
notes: FORMULA: CH2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Formaldehyde

649276
type: Reaction
notes: GENE_ASSOCIATION: (6566.1) or (9194.1) GENE_LIST: 6566.1 9194.1 SUBSYSTEM: D-alanine metabolism
product: 104944
kinetic law: 104968
reactant: 104919
name: pyruvate peroxisomal transport via proton symport
product: 104956
reactant: 104931
fast: false
reversible: true

104944
type: SpeciesReference
stoichiometry: 1.0
species: 645721

659209
type: LocalParameter
units: 032971
value: 0.0

659208
type: LocalParameter
value: 0.0

659206
type: LocalParameter
units: 033007
value: 1000.0

659205
type: LocalParameter
units: 033007
value: -1000.0

104919
type: SpeciesReference
stoichiometry: 1.0
species: 645712

104956
type: SpeciesReference
stoichiometry: 1.0
species: 646285

646285
type: Species
notes: FORMULA: C3H3O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Pyruvate

104931
type: SpeciesReference
stoichiometry: 1.0
species: 646280

646774
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 5dhf_b

650035
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) GENE_LIST: 2180.1 SUBSYSTEM: Fatty acid activation
name: fatty-acid--CoA ligase
reversible: true
product: 119935
reactant: 119899
product: 119959
reactant: 119911
kinetic law: 119971
fast: false
product: 119947
reactant: 119923

119935
type: SpeciesReference
stoichiometry: 1.0
species: 645037

119899
type: SpeciesReference
stoichiometry: 1.0
species: 645088

119959
type: SpeciesReference
stoichiometry: 1.0
species: 646582

646582
type: Species
notes: FORMULA: C39H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: vaccenyl coenzyme A

119911
type: SpeciesReference
stoichiometry: 1.0
species: 645223

660627
type: LocalParameter
units: 032971
value: 0.0

660626
type: LocalParameter
value: 0.0

660578
type: LocalParameter
units: 033007
value: 1000.0

660577
type: LocalParameter
units: 033007
value: -1000.0

119947
type: SpeciesReference
stoichiometry: 1.0
species: 646222

119923
type: SpeciesReference
stoichiometry: 1.0
species: 646579

646579
type: Species
notes: FORMULA: C18H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: vaccenic acid

646039
type: Species
notes: FORMULA: C11H14N2O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: NMN

645790
type: Species
notes: FORMULA: C3H3O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Hydroxypyruvate

647777
type: Reaction
reactant: 059571
product: 059619
reversible: false
notes: SUBSYSTEM: beta-Alanine metabolism
reactant: 059559
fast: false
product: 059595
kinetic law: 059631
reactant: 059583
name: Spermidine:(acceptor) oxidoreductase
product: 059607

059571
type: SpeciesReference
stoichiometry: 1.0
species: 646060

059619
type: SpeciesReference
stoichiometry: 1.0
species: 645692

059559
type: SpeciesReference
stoichiometry: 1.0
species: 645700

059595
type: SpeciesReference
stoichiometry: 1.0
species: 644656

654673
type: LocalParameter
units: 032971
value: 500.0

654671
type: LocalParameter
value: 0.0

654669
type: LocalParameter
units: 033007
value: 1000.0

654667
type: LocalParameter
units: 033007
value: 0.0

059583
type: SpeciesReference
stoichiometry: 1.0
species: 646358

646358
type: Species
notes: FORMULA: C7H22N3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Spermidine

059607
type: SpeciesReference
stoichiometry: 1.0
species: 644765

644765
type: Species
notes: FORMULA: C4H10NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4-Aminobutanal

647092
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ttdca_b

647926
type: Reaction
kinetic law: 065357
product: 065345
reactant: 065333
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport

655366
type: LocalParameter
units: 032971
value: 0.0

655364
type: LocalParameter
value: 0.0

655362
type: LocalParameter
units: 033007
value: 1000.0

655360
type: LocalParameter
units: 033007
value: -1000.0

065345
type: SpeciesReference
stoichiometry: 1.0
species: 645791

645791
type: Species
notes: FORMULA: C47H31NO15
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: hydroxylated taxol

065333
type: SpeciesReference
stoichiometry: 1.0
species: 645793

645793
type: Species
notes: FORMULA: C47H31NO15
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hydroxylated taxol

646537
type: Species
notes: FORMULA: C9H11N2O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: UDP

645674
type: Species
notes: FORMULA: C10H12N5O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: GTP

648604
type: Reaction
product: 089989
reactant: 089977
reactant: 089965
kinetic law: 090049
product: 090025
reactant: 089928
name: Beta oxidation of long chain fatty acid
reversible: false
product: 090001
product: 090037
product: 090013
reactant: 089953
fast: false
notes: GENE_ASSOCIATION: (35.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
reactant: 089941

089989
type: SpeciesReference
stoichiometry: 1.0
species: 644941

089977
type: SpeciesReference
stoichiometry: 1.0
species: 645998

089965
type: SpeciesReference
stoichiometry: 1.0
species: 645704

657901
type: LocalParameter
units: 032971
value: 500.0

657899
type: LocalParameter
value: 0.0

657898
type: LocalParameter
units: 033007
value: 1000.0

657897
type: LocalParameter
units: 033007
value: 0.0

090025
type: SpeciesReference
stoichiometry: 1.0
species: 646006

089928
type: SpeciesReference
stoichiometry: 1.0
species: 645053

645053
type: Species
notes: FORMULA: C41H70N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: arachidyl coenzyme A

090001
type: SpeciesReference
stoichiometry: 1.0
species: 645518

090037
type: SpeciesReference
stoichiometry: 1.0
species: 646367

646367
type: Species
notes: FORMULA: C39H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Stearoyl-CoA (n-C18:0CoA)

090013
type: SpeciesReference
stoichiometry: 1.0
species: 645716

089953
type: SpeciesReference
stoichiometry: 1.0
species: 645512

089941
type: SpeciesReference
stoichiometry: 1.0
species: 645224

647363
type: Reaction
kinetic law: 042964
product: 042952
reactant: 042940
fast: false
reversible: true
name: 13-cis-retinoyl glucuronide exchange

652403
type: LocalParameter
units: 032971
value: 0.0

652400
type: LocalParameter
value: 0.0

652397
type: LocalParameter
units: 033007
value: 1000.0

652394
type: LocalParameter
units: 033007
value: -1000.0

042952
type: SpeciesReference
stoichiometry: 1.0
species: 646783

646783
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Rtotal2_b

042940
type: SpeciesReference
stoichiometry: 1.0
species: 644653

644653
type: Species
notes: FORMULA: C26H35O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 13-cis-retinoyl glucuronide

647047
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: sprm_b

645404
type: Species
notes: FORMULA: C5H9O7P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Dimethylallyl diphosphate

644788
type: Species
notes: FORMULA: C28H44O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 4-Methylzymosterol intermediate 2

645346
type: Species
notes: FORMULA: C10H12N5O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dGTP

647206
type: Reaction
reactant: 036498
product: 036522
product: 036534
product: 036510
notes: GENE_ASSOCIATION: (4200.1) or (10873.1) GENE_LIST: 10873.1 4200.1 SUBSYSTEM: Pyruvate Metabolism
reactant: 036486
kinetic law: 036546
fast: false
reversible: false
name: malic enzyme (NADP), mitochondrial

036498
type: SpeciesReference
stoichiometry: 1.0
species: 646013

036522
type: SpeciesReference
stoichiometry: 1.0
species: 646019

036534
type: SpeciesReference
stoichiometry: 1.0
species: 646283

646283
type: Species
notes: FORMULA: C3H3O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Pyruvate

036510
type: SpeciesReference
stoichiometry: 1.0
species: 645215

036486
type: SpeciesReference
stoichiometry: 1.0
species: 645926

645926
type: Species
notes: FORMULA: C4H4O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Malate

651361
type: LocalParameter
units: 032971
value: 500.0

651358
type: LocalParameter
value: 0.0

651355
type: LocalParameter
units: 033007
value: 1000.0

651354
type: LocalParameter
units: 033007
value: 0.0

650312
type: Reaction
kinetic law: 125486
product: 125474
reactant: 125462
fast: false
reversible: true
name: octanoate (n-C8:0) exchange

661140
type: LocalParameter
units: 032971
value: 0.0

661138
type: LocalParameter
value: 0.0

661137
type: LocalParameter
units: 033007
value: 1000.0

661135
type: LocalParameter
units: 033007
value: -1000.0

125474
type: SpeciesReference
stoichiometry: 1.0
species: 647067

647067
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tdchola_b

125462
type: SpeciesReference
stoichiometry: 1.0
species: 646087

646087
type: Species
notes: FORMULA: C8H15O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: octanoate (n-C8:0)

645586
type: Species
notes: FORMULA: C10H12N5O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: GDP

647369
type: Reaction
name: fatty acyl-CoA synthase (n-C8:0CoA), lumped reaction
product: 043228
reversible: false
reactant: 043132
notes: GENE_ASSOCIATION: (2194.1) GENE_LIST: 2194.1 SUBSYSTEM: Fatty acid elongation
product: 043192
reactant: 043168
product: 043204
fast: false
product: 043216
reactant: 043156
reactant: 043144
product: 043180
kinetic law: 043240

043228
type: SpeciesReference
stoichiometry: 1.0
species: 646075

646075
type: Species
notes: FORMULA: C29H46N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Octanoyl-CoA (n-C8:0CoA)

043132
type: SpeciesReference
stoichiometry: 1.0
species: 644939

644939
type: Species
notes: FORMULA: C23H34N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Acetyl-CoA

043192
type: SpeciesReference
stoichiometry: 3.0
species: 645223

043168
type: SpeciesReference
stoichiometry: 6.0
species: 646018

043204
type: SpeciesReference
stoichiometry: 3.0
species: 645700

043216
type: SpeciesReference
stoichiometry: 6.0
species: 646010

043156
type: SpeciesReference
stoichiometry: 3.0
species: 645928

043144
type: SpeciesReference
stoichiometry: 9.0
species: 645712

043180
type: SpeciesReference
stoichiometry: 3.0
species: 645212

652443
type: LocalParameter
units: 032971
value: 500.0

652440
type: LocalParameter
value: 0.0

652437
type: LocalParameter
units: 033007
value: 1000.0

652434
type: LocalParameter
units: 033007
value: 0.0

650171
type: Reaction
product: 122781
reactant: 122733
fast: false
product: 122794
reactant: 122757
product: 122769
notes: SUBSYSTEM: Lysine Metabolism
kinetic law: 122806
reactant: 122745
reversible: false
name: L-lysine oxidase, peroxisomal

122781
type: SpeciesReference
stoichiometry: 1.0
species: 645698

122733
type: SpeciesReference
stoichiometry: 1.0
species: 645709

122794
type: SpeciesReference
stoichiometry: 1.0
species: 646033

646033
type: Species
notes: FORMULA: H4N
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Ammonium

122757
type: SpeciesReference
stoichiometry: 1.0
species: 646064

122769
type: SpeciesReference
stoichiometry: 1.0
species: 644840

644840
type: Species
notes: FORMULA: C6H11NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: 6-Amino-2-oxohexanoate

660881
type: LocalParameter
units: 032971
value: 500.0

660880
type: LocalParameter
value: 0.0

660878
type: LocalParameter
units: 033007
value: 1000.0

660877
type: LocalParameter
units: 033007
value: 0.0

122745
type: SpeciesReference
stoichiometry: 1.0
species: 645920

644771
type: Species
notes: FORMULA: C5H9NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-4-Hydroxyglutamate semialdehyde

644681
type: Species
notes: FORMULA: C5H7O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2-keto-4-methylthiobutyrate

649618
type: Reaction
kinetic law: 111911
product: 111899
reactant: 111887
reactant: 111874
notes: SUBSYSTEM: Miscellaneous
fast: false
reversible: true
name: carboxylic acid dissociation

659821
type: LocalParameter
units: 032971
value: 0.0

659819
type: LocalParameter
value: 0.0

659818
type: LocalParameter
units: 033007
value: 1000.0

659816
type: LocalParameter
units: 033007
value: -1000.0

111899
type: SpeciesReference
stoichiometry: 1.0
species: 645689

645689
type: Species
notes: FORMULA: H2CO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: carbonic acid

111887
type: SpeciesReference
stoichiometry: 1.0
species: 645730

111874
type: SpeciesReference
stoichiometry: 1.0
species: 645712

645916
type: Species
notes: FORMULA: C6H15N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Lysine

645734
type: Species
notes: FORMULA: C9H6O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: hydroxy coumarin

650041
type: Reaction
kinetic law: 120091
product: 120079
reactant: 120067
fast: false
reversible: true
name: omega hydroxy tetradecanoate (n-C14:0) exchange

660639
type: LocalParameter
units: 032971
value: 0.0

660638
type: LocalParameter
value: 0.0

660637
type: LocalParameter
units: 033007
value: 1000.0

660633
type: LocalParameter
units: 033007
value: -1000.0

120079
type: SpeciesReference
stoichiometry: 1.0
species: 647043

647043
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: so4_b

120067
type: SpeciesReference
stoichiometry: 1.0
species: 646600

646600
type: Species
notes: FORMULA: C14H27O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: omega hydroxy tetradecanoate (n-C14:0)

647737
type: Reaction
kinetic law: 057870
product: 057858
reactant: 057846
notes: GENE_ASSOCIATION: (2352.1) or (2348.6) or (2348.4) or (2348.1) or (2348.3) or (2351.1) or (2348.2) or (2348.5) GENE_LIST: 2348.1 2348.2 2348.3 2348.4 2348.5 2348.6 2351.1 2352.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: 5-Methyltetrahydrofolate transport via receptor binding and protolysis

654484
type: LocalParameter
units: 032971
value: 0.0

654482
type: LocalParameter
value: 0.0

654480
type: LocalParameter
units: 033007
value: 1000.0

654478
type: LocalParameter
units: 033007
value: -1000.0

057858
type: SpeciesReference
stoichiometry: 1.0
species: 644828

057846
type: SpeciesReference
stoichiometry: 1.0
species: 644830

648325
type: Reaction
kinetic law: 078767
product: 078755
reactant: 078743
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: urate export from cytosol

656917
type: LocalParameter
units: 032971
value: 500.0

656916
type: LocalParameter
value: 0.0

656915
type: LocalParameter
units: 033007
value: 1000.0

656914
type: LocalParameter
units: 033007
value: 0.0

078755
type: SpeciesReference
stoichiometry: 1.0
species: 646561

078743
type: SpeciesReference
stoichiometry: 1.0
species: 646559

646559
type: Species
notes: FORMULA: C5H4N4O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Urate

645913
type: Species
notes: FORMULA: S2X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Lipoylprotein

645821
type: Species
notes: FORMULA: C10H12N4O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Inosine

646824
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: bhb_b

648110
type: Reaction
product: 072713
name: Squalene epoxidase, endoplasmic reticular (NADP)
product: 072725
reversible: false
reactant: 072665
notes: GENE_ASSOCIATION: (6713.1) GENE_LIST: 6713.1 SUBSYSTEM: Cholesterol Metabolism
kinetic law: 072737
reactant: 072653
reactant: 072689
product: 072701
reactant: 072677
fast: false

072713
type: SpeciesReference
stoichiometry: 1.0
species: 645707

645707
type: Species
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: H2O

072725
type: SpeciesReference
stoichiometry: 1.0
species: 646015

646015
type: Species
notes: FORMULA: C21H25N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Nicotinamide adenine dinucleotide phosphate

072665
type: SpeciesReference
stoichiometry: 1.0
species: 646021

646021
type: Species
notes: FORMULA: C21H26N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Nicotinamide adenine dinucleotide phosphate - reduced

656267
type: LocalParameter
units: 032971
value: 500.0

656265
type: LocalParameter
value: 0.0

656263
type: LocalParameter
units: 033007
value: 1000.0

656261
type: LocalParameter
units: 033007
value: 0.0

072653
type: SpeciesReference
stoichiometry: 1.0
species: 645719

645719
type: Species
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: H+

072689
type: SpeciesReference
stoichiometry: 1.0
species: 646361

646361
type: Species
notes: FORMULA: C30H50
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Squalene

072701
type: SpeciesReference
stoichiometry: 1.0
species: 644911

644911
type: Species
notes: FORMULA: C30H50O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: (S)-Squalene-2,3-epoxide

072677
type: SpeciesReference
stoichiometry: 1.0
species: 646063

646063
type: Species
notes: FORMULA: O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: O2

646078
type: Species
notes: FORMULA: C29H46N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Octanoyl-CoA (n-C8:0CoA)

644947
type: Species
notes: FORMULA: C3H6O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Acetone

646490
type: Species
notes: FORMULA: C15H11I4NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Thyroxine

645637
type: Species
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Glycine betaine

646857
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: dctp_b

645242
type: Species
notes: FORMULA: C18H36NO2FULLRCO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: ceramide (homo sapiens)

647629
type: Reaction
kinetic law: 053308
name: succinate transport, mitochondrial
notes: GENE_ASSOCIATION: (1468.1) GENE_LIST: 1468.1 SUBSYSTEM: Transport, Mitochondrial
product: 053284
reactant: 053272
reversible: true
reactant: 053260
fast: false
product: 053296

653980
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value: 0.0

653978
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value: 0.0

653976
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units: 033007
value: 1000.0

653974
type: LocalParameter
units: 033007
value: -1000.0

053284
type: SpeciesReference
stoichiometry: 1.0
species: 646193

053272
type: SpeciesReference
stoichiometry: 1.0
species: 646387

646387
type: Species
notes: FORMULA: C4H4O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Succinate

053260
type: SpeciesReference
stoichiometry: 1.0
species: 646196

053296
type: SpeciesReference
stoichiometry: 1.0
species: 646390

645599
type: Species
notes: FORMULA: C6H9O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Glucuronate

650690
type: Reaction
product: 136660
fast: false
reactant: 136636
name: succinate dehydrogenase
reactant: 136648
reversible: true
kinetic law: 136684
notes: GENE_ASSOCIATION: (6389.1 and 6392.1 and 6391.1 and 6390.1) GENE_LIST: 6389.1 6390.1 6391.1 6392.1 SUBSYSTEM: Citric Acid Cycle
product: 136672

136660
type: SpeciesReference
stoichiometry: 1.0
species: 645518

136636
type: SpeciesReference
stoichiometry: 1.0
species: 645512

136648
type: SpeciesReference
stoichiometry: 1.0
species: 646390

662174
type: LocalParameter
units: 032971
value: 0.0

662172
type: LocalParameter
value: 0.0

662171
type: LocalParameter
units: 033007
value: 1000.0

662169
type: LocalParameter
units: 033007
value: -1000.0

136672
type: SpeciesReference
stoichiometry: 1.0
species: 645557

648370
type: Reaction
kinetic law: 080506
product: 080494
reactant: 080482
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: L-proline transport, mitochondrial

657201
type: LocalParameter
units: 032971
value: 0.0

657200
type: LocalParameter
value: 0.0

657199
type: LocalParameter
units: 033007
value: 1000.0

657198
type: LocalParameter
units: 033007
value: -1000.0

080494
type: SpeciesReference
stoichiometry: 1.0
species: 646243

646243
type: Species
notes: FORMULA: C5H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Proline

080482
type: SpeciesReference
stoichiometry: 1.0
species: 646240

646240
type: Species
notes: FORMULA: C5H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Proline

650811
type: Reaction
notes: GENE_ASSOCIATION: (6319.1) GENE_LIST: 6319.1 SUBSYSTEM: Fatty acid elongation
kinetic law: 140519
product: 140483
reactant: 140434
fast: false
name: palmitoyl-CoA desaturase (n-C16:0CoA -> n-C16:1CoA)
reactant: 140459
reactant: 140447
product: 140495
product: 140507
reversible: false
reactant: 140471

662527
type: LocalParameter
units: 032971
value: 500.0

662525
type: LocalParameter
value: 0.0

662523
type: LocalParameter
units: 033007
value: 1000.0

662522
type: LocalParameter
units: 033007
value: 0.0

140483
type: SpeciesReference
stoichiometry: 2.0
species: 645700

140434
type: SpeciesReference
stoichiometry: 1.0
species: 645712

140459
type: SpeciesReference
stoichiometry: 1.0
species: 646060

140447
type: SpeciesReference
stoichiometry: 1.0
species: 646004

140495
type: SpeciesReference
stoichiometry: 1.0
species: 645746

140507
type: SpeciesReference
stoichiometry: 1.0
species: 645995

140471
type: SpeciesReference
stoichiometry: 1.0
species: 646202

645457
type: Species
notes: FORMULA: C17H12O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 8,9 epxoy aflatoxin B1

644797
type: Species
notes: FORMULA: C12H20N2O9PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine

650346
type: Reaction
kinetic law: 126493
product: 126481
reactant: 126469
fast: false
reversible: true
name: Uracil exchange

661228
type: LocalParameter
units: 032971
value: 0.0

661226
type: LocalParameter
value: 0.0

661225
type: LocalParameter
units: 033007
value: 1000.0

661223
type: LocalParameter
units: 033007
value: -1000.0

126481
type: SpeciesReference
stoichiometry: 1.0
species: 647073

647073
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tettet6_b

126469
type: SpeciesReference
stoichiometry: 1.0
species: 646558

646558
type: Species
notes: FORMULA: C4H4N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Uracil

647981
type: Reaction
reactant: 067443
fast: false
product: 067503
kinetic law: 067515
reactant: 067431
name: kynurenine 3-monooxygenase
reversible: false
reactant: 067455
notes: GENE_ASSOCIATION: (8564.1) GENE_LIST: 8564.1 SUBSYSTEM: Tryptophan metabolism
product: 067491
product: 067479
reactant: 067467

067443
type: SpeciesReference
stoichiometry: 1.0
species: 645712

067503
type: SpeciesReference
stoichiometry: 1.0
species: 646010

655678
type: LocalParameter
units: 032971
value: 500.0

655676
type: LocalParameter
value: 0.0

655674
type: LocalParameter
units: 033007
value: 1000.0

655672
type: LocalParameter
units: 033007
value: 0.0

067431
type: SpeciesReference
stoichiometry: 1.0
species: 644881

644881
type: Species
notes: FORMULA: C10H12N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Kynurenine

067455
type: SpeciesReference
stoichiometry: 1.0
species: 646018

067491
type: SpeciesReference
stoichiometry: 1.0
species: 645710

645710
type: Species
notes: FORMULA: C10H12N2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Hydroxy-L-kynurenine

067479
type: SpeciesReference
stoichiometry: 1.0
species: 645700

067467
type: SpeciesReference
stoichiometry: 1.0
species: 646060

648205
type: Reaction
reactant: 075329
kinetic law: 075365
product: 075341
notes: GENE_ASSOCIATION: (4860.1) GENE_LIST: 4860.1 SUBSYSTEM: Nucleotides
fast: false
reactant: 075317
name: purine-nucleoside phosphorylase (Xanthosine)
reversible: true
product: 075353

075329
type: SpeciesReference
stoichiometry: 1.0
species: 646651

646651
type: Species
notes: FORMULA: C10H12N4O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Xanthosine

656560
type: LocalParameter
units: 032971
value: 0.0

656558
type: LocalParameter
value: 0.0

656556
type: LocalParameter
units: 033007
value: 1000.0

656554
type: LocalParameter
units: 033007
value: -1000.0

075341
type: SpeciesReference
stoichiometry: 1.0
species: 646291

646291
type: Species
notes: FORMULA: C5H9O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: alpha-D-Ribose 1-phosphate

075317
type: SpeciesReference
stoichiometry: 1.0
species: 646193

075353
type: SpeciesReference
stoichiometry: 1.0
species: 646601

646914
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: gthrd_b

645544
type: Species
notes: FORMULA: CH1O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Formate

644884
type: Species
notes: FORMULA: C6H7NO5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Acetyl-L-aspartate

649234
type: Reaction
kinetic law: 104110
product: 104098
product: 104086
reactant: 104074
notes: GENE_ASSOCIATION: (39.1) GENE_LIST: 39.1 SUBSYSTEM: Cholesterol Metabolism
fast: false
reversible: false
name: acetyl-CoA C-acetyltransferase

659133
type: LocalParameter
units: 032971
value: 500.0

659132
type: LocalParameter
value: 0.0

659131
type: LocalParameter
units: 033007
value: 1000.0

659130
type: LocalParameter
units: 033007
value: 0.0

104098
type: SpeciesReference
stoichiometry: 1.0
species: 645223

104086
type: SpeciesReference
stoichiometry: 1.0
species: 644914

644914
type: Species
notes: FORMULA: C25H36N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Acetoacetyl-CoA

104074
type: SpeciesReference
stoichiometry: 2.0
species: 644939

644794
type: Species
notes: FORMULA: C6H4NO6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 4-Nitrophenyl sulfate

648841
type: Reaction
kinetic law: 095818
product: 095806
reactant: 095794
notes: SUBSYSTEM: Arginine and Proline Metabolism
fast: false
reversible: true
name: 5-methylthioribose-1-phosphate isomerase

658403
type: LocalParameter
units: 032971
value: 0.0

658402
type: LocalParameter
value: 0.0

658401
type: LocalParameter
units: 033007
value: 1000.0

658400
type: LocalParameter
units: 033007
value: -1000.0

095806
type: SpeciesReference
stoichiometry: 1.0
species: 644825

644825
type: Species
notes: FORMULA: C6H11O7PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5-Methylthio-5-deoxy-D-ribulose 1-phosphate

095794
type: SpeciesReference
stoichiometry: 1.0
species: 644824

644824
type: Species
notes: FORMULA: C6H11O7PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5-Methylthio-5-deoxy-D-ribose 1-phosphate

648907
type: Reaction
reactant: 097447
reactant: 097420
reversible: false
name: 4-Pyridoxal secretion
reactant: 097434
product: 097500
product: 097460
notes: SUBSYSTEM: Transport, Extracellular
product: 097474
kinetic law: 097512
product: 097487
fast: false

097447
type: SpeciesReference
stoichiometry: 1.0
species: 645700

097420
type: SpeciesReference
stoichiometry: 1.0
species: 644798

644798
type: Species
notes: FORMULA: C8H9NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4-Pyridoxate

097434
type: SpeciesReference
stoichiometry: 1.0
species: 645088

097500
type: SpeciesReference
stoichiometry: 1.0
species: 646193

097460
type: SpeciesReference
stoichiometry: 1.0
species: 644800

644800
type: Species
notes: FORMULA: C8H9NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 4-Pyridoxate

097474
type: SpeciesReference
stoichiometry: 1.0
species: 644974

658514
type: LocalParameter
units: 032971
value: 500.0

658513
type: LocalParameter
value: 0.0

658512
type: LocalParameter
units: 033007
value: 1000.0

658511
type: LocalParameter
units: 033007
value: 0.0

097487
type: SpeciesReference
stoichiometry: 1.0
species: 645712

647008
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: pe_hs_b

648254
type: Reaction
name: retinol dehydrogenase (all-trans)
fast: false
product: 076733
reactant: 076709
notes: GENE_ASSOCIATION: (8608.1) or (5959.1) GENE_LIST: 5959.1 8608.1 SUBSYSTEM: Vitamin A Metabolism
product: 076745
kinetic law: 076757
reversible: true
reactant: 076697
product: 076721

076733
type: SpeciesReference
stoichiometry: 1.0
species: 646004

076709
type: SpeciesReference
stoichiometry: 1.0
species: 646298

646298
type: Species
notes: FORMULA: C20H30O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Retinol

076745
type: SpeciesReference
stoichiometry: 1.0
species: 646297

646297
type: Species
notes: FORMULA: C20H28O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Retinal

656733
type: LocalParameter
units: 032971
value: 0.0

656731
type: LocalParameter
value: 0.0

656729
type: LocalParameter
units: 033007
value: 1000.0

656727
type: LocalParameter
units: 033007
value: -1000.0

076697
type: SpeciesReference
stoichiometry: 1.0
species: 645995

076721
type: SpeciesReference
stoichiometry: 1.0
species: 645712

645217
type: Species
notes: FORMULA: CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: CO2

647509
type: Reaction
kinetic law: 048657
product: 048645
reactant: 048633
notes: SUBSYSTEM: D-alanine metabolism
fast: false
reversible: false
name: D-Alanine transport to perixosome

653363
type: LocalParameter
units: 032971
value: 500.0

653360
type: LocalParameter
value: 0.0

653357
type: LocalParameter
units: 033007
value: 1000.0

653354
type: LocalParameter
units: 033007
value: 0.0

048645
type: SpeciesReference
stoichiometry: 1.0
species: 645019

645019
type: Species
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: D-Alanine

048633
type: SpeciesReference
stoichiometry: 1.0
species: 645016

645016
type: Species
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Alanine

647390
type: Reaction
kinetic law: 044047
product: 044035
reactant: 044023
notes: GENE_ASSOCIATION: (2944.1) or (2944.2) GENE_LIST: 2944.1 2944.2 SUBSYSTEM: Vitamin A Metabolism
fast: false
reversible: true
name: 13-cis-retinoic acid isomerase

652581
type: LocalParameter
units: 032971
value: 0.0

652578
type: LocalParameter
value: 0.0

652575
type: LocalParameter
units: 033007
value: 1000.0

652572
type: LocalParameter
units: 033007
value: -1000.0

044035
type: SpeciesReference
stoichiometry: 1.0
species: 644648

044023
type: SpeciesReference
stoichiometry: 1.0
species: 646301

646301
type: Species
notes: FORMULA: C20H27O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Retinoate

647005
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: paf_hs_b

650642
type: Reaction
product: 135113
reactant: 135089
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
reactant: 135077
reversible: false
fast: false
name: C226 transport into the mitochondria
product: 135101
kinetic law: 135125

135113
type: SpeciesReference
stoichiometry: 1.0
species: 645247

135089
type: SpeciesReference
stoichiometry: 1.0
species: 645224

135077
type: SpeciesReference
stoichiometry: 1.0
species: 645133

645133
type: Species
notes: FORMULA: C29H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: cervonyl carnitine

135101
type: SpeciesReference
stoichiometry: 1.0
species: 645128

662042
type: LocalParameter
units: 032971
value: 500.0

662040
type: LocalParameter
value: 0.0

662039
type: LocalParameter
units: 033007
value: 1000.0

662037
type: LocalParameter
units: 033007
value: 0.0

650538
type: Reaction
product: 131950
kinetic law: 131974
name: glucose-6-phosphate phosphatase, edoplasmic reticular
fast: false
notes: GENE_ASSOCIATION: (57818.1) or (2538.1) or (92579.1) GENE_LIST: 2538.1 57818.1 92579.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
reactant: 131926
product: 131962
reversible: false
reactant: 131938

131950
type: SpeciesReference
stoichiometry: 1.0
species: 645596

645596
type: Species
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: D-Glucose

661756
type: LocalParameter
units: 032971
value: 500.0

661754
type: LocalParameter
value: 0.0

661753
type: LocalParameter
units: 033007
value: 1000.0

661751
type: LocalParameter
units: 033007
value: 0.0

131926
type: SpeciesReference
stoichiometry: 1.0
species: 645565

645565
type: Species
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: D-Glucose 6-phosphate

131962
type: SpeciesReference
stoichiometry: 1.0
species: 646199

646199
type: Species
notes: FORMULA: HO4P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Phosphate

131938
type: SpeciesReference
stoichiometry: 1.0
species: 645707

645299
type: Species
notes: FORMULA: C45H70N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: chenodeoxycholoyl coenzyme a

650267
type: Reaction
notes: GENE_ASSOCIATION: (1557.1) GENE_LIST: 1557.1 SUBSYSTEM: CYP Metabolism
reactant: 124499
reversible: false
product: 124551
fast: false
reactant: 124486
name: cytochrome P450 2C19
product: 124564
product: 124538
reactant: 124525
reactant: 124512
kinetic law: 124577

124499
type: SpeciesReference
stoichiometry: 1.0
species: 646018

124551
type: SpeciesReference
stoichiometry: 1.0
species: 645700

124486
type: SpeciesReference
stoichiometry: 1.0
species: 645712

124564
type: SpeciesReference
stoichiometry: 1.0
species: 646010

124538
type: SpeciesReference
stoichiometry: 1.0
species: 644819

644819
type: Species
notes: FORMULA: C17H19N3O4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5 hydroxy omeprazole

124525
type: SpeciesReference
stoichiometry: 1.0
species: 646102

646102
type: Species
notes: FORMULA: C17H19N3O3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: omeprazole

124512
type: SpeciesReference
stoichiometry: 1.0
species: 646060

661057
type: LocalParameter
units: 032971
value: 500.0

661056
type: LocalParameter
value: 0.0

661054
type: LocalParameter
units: 033007
value: 1000.0

661053
type: LocalParameter
units: 033007
value: 0.0

648772
type: Reaction
kinetic law: 094332
reversible: false
name: alcohol dehydrogenase (L-lactaldehyde)
reactant: 094272
fast: false
product: 094296
product: 094320
notes: GENE_ASSOCIATION: (126.1) or (137872.1) or (126.1 and 124.1) or (127.1) or (130.1) or (284273.1) or (125.1 and 124.1) or (128.1) or (124.1) or (125.1) or (284273.2) or (131.1) or (125.1 and 126.1) GENE_LIST: 124.1 125.1 126.1 127.1 128.1 130.1 131.1 137872.1 284273.1 284273.2 SUBSYSTEM: Pyruvate Metabolism
product: 094308
reactant: 094284

658269
type: LocalParameter
units: 032971
value: 500.0

658268
type: LocalParameter
value: 0.0

658267
type: LocalParameter
units: 033007
value: 1000.0

658266
type: LocalParameter
units: 033007
value: 0.0

094272
type: SpeciesReference
stoichiometry: 1.0
species: 645851

645851
type: Species
notes: FORMULA: C3H6O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Lactaldehyde

094296
type: SpeciesReference
stoichiometry: 1.0
species: 645712

094320
type: SpeciesReference
stoichiometry: 1.0
species: 646004

094308
type: SpeciesReference
stoichiometry: 1.0
species: 645985

094284
type: SpeciesReference
stoichiometry: 1.0
species: 645995

648644
type: Reaction
kinetic law: 091236
product: 091224
reactant: 091212
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: sodium transport via diffusion (perioxisome)

658014
type: LocalParameter
units: 032971
value: 0.0

658013
type: LocalParameter
value: 0.0

658012
type: LocalParameter
units: 033007
value: 1000.0

658011
type: LocalParameter
units: 033007
value: -1000.0

091224
type: SpeciesReference
stoichiometry: 1.0
species: 645991

645991
type: Species
notes: FORMULA: Na
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Sodium

091212
type: SpeciesReference
stoichiometry: 1.0
species: 645988

645988
type: Species
notes: FORMULA: Na
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sodium

645647
type: Species
notes: FORMULA: C2H3O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Glycolate

647492
type: Reaction
kinetic law: 047969
fast: false
reversible: false
name: phosphopantothenoylcysteine decarboxylase
notes: GENE_ASSOCIATION: (60490.1) GENE_LIST: 60490.1 SUBSYSTEM: CoA Biosynthesis
product: 047957
reactant: 047933
reactant: 047921
product: 047945

653257
type: LocalParameter
units: 032971
value: 500.0

653254
type: LocalParameter
value: 0.0

653251
type: LocalParameter
units: 033007
value: 1000.0

653248
type: LocalParameter
units: 033007
value: 0.0

047957
type: SpeciesReference
stoichiometry: 1.0
species: 646147

646147
type: Species
notes: FORMULA: C11H21N2O7PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Pantetheine 4'-phosphate

047933
type: SpeciesReference
stoichiometry: 1.0
species: 645712

047921
type: SpeciesReference
stoichiometry: 1.0
species: 644797

047945
type: SpeciesReference
stoichiometry: 1.0
species: 645212

648316
type: Reaction
kinetic law: 078421
product: 078409
reactant: 078397
fast: false
reversible: true
name: tetracosapentaenoic acid, n-6 exchange

656890
type: LocalParameter
units: 032971
value: 0.0

656889
type: LocalParameter
value: 0.0

656888
type: LocalParameter
units: 033007
value: 1000.0

656885
type: LocalParameter
units: 033007
value: -1000.0

078409
type: SpeciesReference
stoichiometry: 1.0
species: 646894

646894
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: fuc_DASH_L_b

078397
type: SpeciesReference
stoichiometry: 1.0
species: 646441

646441
type: Species
notes: FORMULA: C24H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetracosapentaenoic acid, n-6

648613
type: Reaction
reversible: false
product: 090315
product: 090302
name: 5'-nucleotidase (dUMP)
notes: GENE_ASSOCIATION: (30833.1) GENE_LIST: 30833.1 SUBSYSTEM: Pyrimidine Catabolism
reactant: 090290
fast: false
kinetic law: 090327
reactant: 090278

090315
type: SpeciesReference
stoichiometry: 1.0
species: 646193

090302
type: SpeciesReference
stoichiometry: 1.0
species: 645442

090290
type: SpeciesReference
stoichiometry: 1.0
species: 645700

657922
type: LocalParameter
units: 032971
value: 500.0

657921
type: LocalParameter
value: 0.0

657920
type: LocalParameter
units: 033007
value: 1000.0

657919
type: LocalParameter
units: 033007
value: 0.0

090278
type: SpeciesReference
stoichiometry: 1.0
species: 645437

645437
type: Species
notes: FORMULA: C9H11N2O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dUMP

648658
type: Reaction
kinetic law: 091623
product: 091611
reactant: 091599
fast: false
reversible: true
name: Limonene exchange

658047
type: LocalParameter
units: 032971
value: 0.0

658046
type: LocalParameter
value: 0.0

658045
type: LocalParameter
units: 033007
value: 1000.0

658044
type: LocalParameter
units: 033007
value: -1000.0

091611
type: SpeciesReference
stoichiometry: 1.0
species: 646936

646936
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: idp_b

091599
type: SpeciesReference
stoichiometry: 1.0
species: 645869

645869
type: Species
notes: FORMULA: C10H16
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Limonene

647792
type: Reaction
kinetic law: 060136
product: 060124
reactant: 060112
fast: false
reversible: true
name: adp exchange

654743
type: LocalParameter
units: 032971
value: 0.0

654741
type: LocalParameter
value: 0.0

654739
type: LocalParameter
units: 033007
value: 1000.0

654737
type: LocalParameter
units: 033007
value: -1000.0

060124
type: SpeciesReference
stoichiometry: 1.0
species: 646837

646837
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: chsterol_b

060112
type: SpeciesReference
stoichiometry: 1.0
species: 644975

644975
type: Species
notes: FORMULA: C10H12N5O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ADP

648014
type: Reaction
reactant: 068698
kinetic law: 068746
product: 068734
name: 5-Hydroxy-L-tryptophan decarboxy-lyase
reactant: 068710
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1644.1) GENE_LIST: 1644.1 SUBSYSTEM: Tryptophan metabolism
product: 068722

068698
type: SpeciesReference
stoichiometry: 1.0
species: 644822

644822
type: Species
notes: FORMULA: C11H12N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5-Hydroxy-L-tryptophan

655832
type: LocalParameter
units: 032971
value: 500.0

655830
type: LocalParameter
value: 0.0

655828
type: LocalParameter
units: 033007
value: 1000.0

655826
type: LocalParameter
units: 033007
value: 0.0

068734
type: SpeciesReference
stoichiometry: 1.0
species: 646363

068710
type: SpeciesReference
stoichiometry: 1.0
species: 645712

068722
type: SpeciesReference
stoichiometry: 1.0
species: 645212

645965
type: Species
notes: FORMULA: C6H9O15P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 1,4,5-trisphosphate

647164
type: Reaction
product: 034792
reversible: false
product: 034804
name: N-acetylglucosamine-6-phosphate deacetylase
notes: GENE_ASSOCIATION: (51005.1) GENE_LIST: 51005.1 SUBSYSTEM: Aminosugar Metabolism
reactant: 034768
fast: false
kinetic law: 034816
reactant: 034780

034792
type: SpeciesReference
stoichiometry: 1.0
species: 644923

644923
type: Species
notes: FORMULA: C2H3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Acetate

034804
type: SpeciesReference
stoichiometry: 1.0
species: 645571

645571
type: Species
notes: FORMULA: C6H13NO8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Glucosamine 6-phosphate

034768
type: SpeciesReference
stoichiometry: 1.0
species: 644953

644953
type: Species
notes: FORMULA: C8H14NO9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Acetyl-D-glucosamine 6-phosphate

651117
type: LocalParameter
units: 032971
value: 500.0

651114
type: LocalParameter
value: 0.0

651111
type: LocalParameter
units: 033007
value: 1000.0

651110
type: LocalParameter
units: 033007
value: 0.0

034780
type: SpeciesReference
stoichiometry: 1.0
species: 645700

648380
type: Reaction
reactant: 080930
notes: GENE_ASSOCIATION: (115584.1) GENE_LIST: 115584.1 SUBSYSTEM: Transport, Extracellular
name: inositol transport via sodium symport
reversible: true
kinetic law: 080966
product: 080942
product: 080954
reactant: 080918
fast: false

080930
type: SpeciesReference
stoichiometry: 2.0
species: 645989

645989
type: Species
notes: FORMULA: Na
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Sodium

657230
type: LocalParameter
units: 032971
value: 0.0

657229
type: LocalParameter
value: 0.0

657228
type: LocalParameter
units: 033007
value: 1000.0

657227
type: LocalParameter
units: 033007
value: -1000.0

080942
type: SpeciesReference
stoichiometry: 1.0
species: 645817

645817
type: Species
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: myo-Inositol

080954
type: SpeciesReference
stoichiometry: 2.0
species: 645988

080918
type: SpeciesReference
stoichiometry: 1.0
species: 645818

645818
type: Species
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: myo-Inositol

649045
type: Reaction
kinetic law: 100541
product: 100528
reactant: 100516
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: choline intracellular transport

658798
type: LocalParameter
units: 032971
value: 0.0

658797
type: LocalParameter
value: 0.0

658796
type: LocalParameter
units: 033007
value: 1000.0

658795
type: LocalParameter
units: 033007
value: -1000.0

100528
type: SpeciesReference
stoichiometry: 1.0
species: 645163

100516
type: SpeciesReference
stoichiometry: 1.0
species: 645169

645169
type: Species
notes: FORMULA: C5H14NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Choline

647201
type: Reaction
kinetic law: 036365
product: 036353
reactant: 036341
fast: false
reversible: true
name: myo-Inositol exchange

651337
type: LocalParameter
units: 032971
value: 0.0

651334
type: LocalParameter
value: 0.0

651331
type: LocalParameter
units: 033007
value: 1000.0

651330
type: LocalParameter
units: 033007
value: -1000.0

036353
type: SpeciesReference
stoichiometry: 1.0
species: 646762

646762
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 3aib_b

036341
type: SpeciesReference
stoichiometry: 1.0
species: 645818

646968
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: lys_DASH_L_b

647062
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: taxol_b

646573
type: Species
notes: FORMULA: C9H12N2O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: Uridine

647678
type: Reaction
kinetic law: 055397
product: 055385
reactant: 055373
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport

654211
type: LocalParameter
units: 032971
value: 0.0

654209
type: LocalParameter
value: 0.0

654207
type: LocalParameter
units: 033007
value: 1000.0

654205
type: LocalParameter
units: 033007
value: -1000.0

055385
type: SpeciesReference
stoichiometry: 1.0
species: 645310

055373
type: SpeciesReference
stoichiometry: 1.0
species: 645307

645307
type: Species
notes: FORMULA: C43H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

645440
type: Species
notes: FORMULA: C9H11N2O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dUMP

645467
type: Species
notes: FORMULA: C20H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: eicosatetranoic acid

645382
type: Species
notes: FORMULA: C10H12N4O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Deoxyinosine

648985
type: Reaction
kinetic law: 099380
product: 099368
reactant: 099356
reactant: 099344
notes: GENE_ASSOCIATION: (6999.1) GENE_LIST: 6999.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: false
name: L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

658706
type: LocalParameter
units: 032971
value: 500.0

658705
type: LocalParameter
value: 0.0

658704
type: LocalParameter
units: 033007
value: 1000.0

658703
type: LocalParameter
units: 033007
value: 0.0

099368
type: SpeciesReference
stoichiometry: 1.0
species: 644879

644879
type: Species
notes: FORMULA: C11H12N2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Formylkynurenine

099356
type: SpeciesReference
stoichiometry: 1.0
species: 646513

646513
type: Species
notes: FORMULA: C11H12N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Tryptophan

099344
type: SpeciesReference
stoichiometry: 1.0
species: 646060

645112
type: Species
notes: FORMULA: C33H34N4O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Bilirubin

648274
type: Reaction
kinetic law: 077300
product: 077288
product: 077276
reactant: 077264
notes: GENE_ASSOCIATION: (2977.1 and 2983.1) or (4882.2) or (2982.1 and 2974.1) or (2986.1) or (4882.1) or (2984.1) or (4881.1) or (2977.1 and 2974.1) or (3000.1) or (2982.1 and 2983.1) GENE_LIST: 2974.1 2977.1 2982.1 2983.1 2984.1 2986.1 3000.1 4881.1 4882.1 4882.2 SUBSYSTEM: Nucleotides
fast: false
reversible: false
name: guanylate cyclase

656789
type: LocalParameter
units: 032971
value: 500.0

656787
type: LocalParameter
value: 0.0

656785
type: LocalParameter
units: 033007
value: 1000.0

656783
type: LocalParameter
units: 033007
value: 0.0

077288
type: SpeciesReference
stoichiometry: 1.0
species: 646222

077276
type: SpeciesReference
stoichiometry: 1.0
species: 644711

644711
type: Species
notes: FORMULA: C10H11N5O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3',5'-Cyclic GMP

077264
type: SpeciesReference
stoichiometry: 1.0
species: 645674

647221
type: Reaction
reactant: 037142
reactant: 037154
fast: false
reversible: false
product: 037190
kinetic law: 037202
notes: GENE_ASSOCIATION: (57379.1) GENE_LIST: 57379.1 SUBSYSTEM: Nucleotides
reactant: 037166
name: deoxycytidine deaminase, nuclear
product: 037178

037142
type: SpeciesReference
stoichiometry: 1.0
species: 645322

037154
type: SpeciesReference
stoichiometry: 1.0
species: 645706

645706
type: Species
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: H2O

037190
type: SpeciesReference
stoichiometry: 1.0
species: 646031

646031
type: Species
notes: FORMULA: H4N
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: Ammonium

651441
type: LocalParameter
units: 032971
value: 500.0

651438
type: LocalParameter
value: 0.0

651435
type: LocalParameter
units: 033007
value: 1000.0

651434
type: LocalParameter
units: 033007
value: 0.0

037166
type: SpeciesReference
stoichiometry: 1.0
species: 645718

645718
type: Species
notes: FORMULA: H
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: H+

037178
type: SpeciesReference
stoichiometry: 1.0
species: 645445

646788
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: abt_b

650050
type: Reaction
notes: GENE_ASSOCIATION: (35.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
product: 120287
reactant: 120249
reactant: 120225
fast: false
reversible: false
kinetic law: 120336
product: 120323
product: 120311
reactant: 120262
product: 120299
name: Beta oxidation of fatty acid
product: 120275
reactant: 120213
reactant: 120237

120287
type: SpeciesReference
stoichiometry: 1.0
species: 645518

120249
type: SpeciesReference
stoichiometry: 1.0
species: 645704

120225
type: SpeciesReference
stoichiometry: 1.0
species: 645394

645394
type: Species
notes: FORMULA: C41H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dihomo-gamma-linolenyl coenzyme A

660656
type: LocalParameter
units: 032971
value: 500.0

660654
type: LocalParameter
value: 0.0

660653
type: LocalParameter
units: 033007
value: 1000.0

660651
type: LocalParameter
units: 033007
value: 0.0

120323
type: SpeciesReference
stoichiometry: 1.0
species: 646006

120311
type: SpeciesReference
stoichiometry: 1.0
species: 645902

120262
type: SpeciesReference
stoichiometry: 1.0
species: 645998

120299
type: SpeciesReference
stoichiometry: 1.0
species: 645716

120275
type: SpeciesReference
stoichiometry: 1.0
species: 644941

120213
type: SpeciesReference
stoichiometry: 1.0
species: 645224

120237
type: SpeciesReference
stoichiometry: 1.0
species: 645512

646875
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: dttp_b

644995
type: Species
notes: FORMULA: C29H49NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Adrenyl carnitine

647438
type: Reaction
kinetic law: 046000
product: 045988
reactant: 045976
fast: false
reversible: true
name: estrone glucuronide exchange

652901
type: LocalParameter
units: 032971
value: 0.0

652898
type: LocalParameter
value: 0.0

652895
type: LocalParameter
units: 033007
value: 1000.0

652892
type: LocalParameter
units: 033007
value: -1000.0

045988
type: SpeciesReference
stoichiometry: 1.0
species: 646790

646790
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: acac_b

045976
type: SpeciesReference
stoichiometry: 1.0
species: 645490

645490
type: Species
notes: FORMULA: C24H30O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: estrone glucuronide

649258
type: Reaction
kinetic law: 104617
product: 104605
reactant: 104592
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion

659178
type: LocalParameter
units: 032971
value: 0.0

659177
type: LocalParameter
value: 0.0

659176
type: LocalParameter
units: 033007
value: 1000.0

659175
type: LocalParameter
units: 033007
value: -1000.0

104605
type: SpeciesReference
stoichiometry: 1.0
species: 645871

645871
type: Species
notes: FORMULA: C18H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: linoelaidic acid (all trans C18:2)

104592
type: SpeciesReference
stoichiometry: 1.0
species: 645872

648334
type: Reaction
notes: GENE_ASSOCIATION: (9415.1) GENE_LIST: 9415.1 SUBSYSTEM: Fatty acid elongation
reactant: 079105
reactant: 079129
product: 079177
kinetic law: 079189
product: 079165
reversible: false
reactant: 079117
fast: false
name: fatty acyl-CoA desaturase (n-C24:5CoA -> n-C24:6CoA)
product: 079153
reactant: 079141

079105
type: SpeciesReference
stoichiometry: 1.0
species: 645712

079129
type: SpeciesReference
stoichiometry: 1.0
species: 646060

079177
type: SpeciesReference
stoichiometry: 1.0
species: 646430

646430
type: Species
notes: FORMULA: C45H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosahexaenoyl coenzyme A

656972
type: LocalParameter
units: 032971
value: 500.0

656971
type: LocalParameter
value: 0.0

656969
type: LocalParameter
units: 033007
value: 1000.0

656968
type: LocalParameter
units: 033007
value: 0.0

079165
type: SpeciesReference
stoichiometry: 1.0
species: 645995

079117
type: SpeciesReference
stoichiometry: 1.0
species: 646004

079153
type: SpeciesReference
stoichiometry: 2.0
species: 645700

079141
type: SpeciesReference
stoichiometry: 1.0
species: 646436

646436
type: Species
notes: FORMULA: C45H68N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosapentaenoyl coenzyme A, n-3

647294
type: Reaction
kinetic law: 040357
product: 040345
reactant: 040333
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: hydroxypyruate transport, peroxisomal

651949
type: LocalParameter
units: 032971
value: 0.0

651946
type: LocalParameter
value: 0.0

651943
type: LocalParameter
units: 033007
value: 1000.0

651940
type: LocalParameter
units: 033007
value: -1000.0

040345
type: SpeciesReference
stoichiometry: 1.0
species: 645790

040333
type: SpeciesReference
stoichiometry: 1.0
species: 645788

645788
type: Species
notes: FORMULA: C3H3O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hydroxypyruvate

648596
type: Reaction
kinetic law: 089627
product: 089615
reactant: 089603
fast: false
reversible: true
name: D-Tagatose exchange

657874
type: LocalParameter
units: 032971
value: 0.0

657873
type: LocalParameter
value: 0.0

657872
type: LocalParameter
units: 033007
value: 1000.0

657871
type: LocalParameter
units: 033007
value: -1000.0

089615
type: SpeciesReference
stoichiometry: 1.0
species: 646926

646926
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hdcea_b

089603
type: SpeciesReference
stoichiometry: 1.0
species: 646402

646402
type: Species
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: D-Tagatose

646208
type: Species
notes: FORMULA: C23H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Palmitoylcarnitine

650810
type: Reaction
kinetic law: 140421
product: 140409
reactant: 140397
fast: false
reversible: true
name: alpha-Tocopherol exchange

662521
type: LocalParameter
units: 032971
value: 0.0

662519
type: LocalParameter
value: 0.0

662517
type: LocalParameter
units: 033007
value: 1000.0

662516
type: LocalParameter
units: 033007
value: -1000.0

140409
type: SpeciesReference
stoichiometry: 1.0
species: 647115

647115
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: xoltri24_b

140397
type: SpeciesReference
stoichiometry: 1.0
species: 645097

645097
type: Species
notes: FORMULA: C29H50O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: alpha-Tocopherol

644992
type: Species
notes: FORMULA: C43H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: adrenyl coenzyme A

647089
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: trp_DASH_L_b

649264
type: Reaction
reactant: 104665
notes: GENE_ASSOCIATION: (60386.1) GENE_LIST: 60386.1 SUBSYSTEM: Transport, Mitochondrial
name: dGTP transport via dGDP antiport
reversible: false
product: 104701
kinetic law: 104713
fast: false
product: 104689
reactant: 104677

104665
type: SpeciesReference
stoichiometry: 1.0
species: 645337

645337
type: Species
notes: FORMULA: C10H12N5O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dGDP

104701
type: SpeciesReference
stoichiometry: 1.0
species: 645347

645347
type: Species
notes: FORMULA: C10H12N5O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dGTP

659188
type: LocalParameter
units: 032971
value: 500.0

659187
type: LocalParameter
value: 0.0

659186
type: LocalParameter
units: 033007
value: 1000.0

659185
type: LocalParameter
units: 033007
value: 0.0

104689
type: SpeciesReference
stoichiometry: 1.0
species: 645335

104677
type: SpeciesReference
stoichiometry: 1.0
species: 645346

646360
type: Species
notes: FORMULA: C10H30N4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Spermine

647638
type: Reaction
kinetic law: 053647
product: 053635
reactant: 053623
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: sphingosine-1-phosphate transport

654022
type: LocalParameter
units: 032971
value: 0.0

654020
type: LocalParameter
value: 0.0

654018
type: LocalParameter
units: 033007
value: 1000.0

654016
type: LocalParameter
units: 033007
value: -1000.0

053635
type: SpeciesReference
stoichiometry: 1.0
species: 646357

646357
type: Species
notes: FORMULA: C18H37NO5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Sphingosine 1-phosphate

053623
type: SpeciesReference
stoichiometry: 1.0
species: 646354

647839
type: Reaction
product: 061904
fast: false
reactant: 061855
reactant: 061843
product: 061891
notes: GENE_ASSOCIATION: (4846.1) or (4844.1) or (4842.1) or (4843.2) or (4843.1) or (4845.1) GENE_LIST: 4842.1 4843.1 4843.2 4844.1 4845.1 4846.1 SUBSYSTEM: Arginine and Proline Metabolism
reactant: 061879
reversible: false
product: 061916
reactant: 061867
kinetic law: 061928
name: Nitric Oxide Synthase (intermediate forming)

061904
type: SpeciesReference
stoichiometry: 1.0
species: 646010

061855
type: SpeciesReference
stoichiometry: 1.0
species: 645712

061843
type: SpeciesReference
stoichiometry: 1.0
species: 645070

061891
type: SpeciesReference
stoichiometry: 1.0
species: 645700

061879
type: SpeciesReference
stoichiometry: 1.0
species: 646060

061916
type: SpeciesReference
stoichiometry: 1.0
species: 646058

646058
type: Species
notes: FORMULA: C6H15N4O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-(omega)-Hydroxyarginine

061867
type: SpeciesReference
stoichiometry: 1.0
species: 646018

654960
type: LocalParameter
units: 032971
value: 500.0

654958
type: LocalParameter
value: 0.0

654956
type: LocalParameter
units: 033007
value: 1000.0

654954
type: LocalParameter
units: 033007
value: 0.0

645415
type: Species
notes: FORMULA: C21H33N7O13P2S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Dephospho-CoA

644755
type: Species
notes: FORMULA: C3H2O5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Sulfinopyruvate

648796
type: Reaction
kinetic law: 094800
product: 094788
reactant: 094776
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: 27 trihydroxy cholesterol transport

658318
type: LocalParameter
units: 032971
value: 0.0

658317
type: LocalParameter
value: 0.0

658316
type: LocalParameter
units: 033007
value: 1000.0

658315
type: LocalParameter
units: 033007
value: -1000.0

094788
type: SpeciesReference
stoichiometry: 1.0
species: 646643

646643
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 7-alpha,27-Dihydroxycholesterol

094776
type: SpeciesReference
stoichiometry: 1.0
species: 646646

646646
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 7-alpha,27-Dihydroxycholesterol

650374
type: Reaction
notes: GENE_ASSOCIATION: (5167.1) GENE_LIST: 5167.1 SUBSYSTEM: Riboflavin Metabolism
kinetic law: 127241
product: 127217
reactant: 127193
product: 127229
reversible: false
product: 127205
fast: false
name: FAD diphosphatase
reactant: 127181

661305
type: LocalParameter
units: 032971
value: 500.0

661303
type: LocalParameter
value: 0.0

661302
type: LocalParameter
units: 033007
value: 1000.0

661300
type: LocalParameter
units: 033007
value: 0.0

127217
type: SpeciesReference
stoichiometry: 1.0
species: 645536

645536
type: Species
notes: FORMULA: C17H19N4O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: FMN

127193
type: SpeciesReference
stoichiometry: 1.0
species: 645700

127229
type: SpeciesReference
stoichiometry: 2.0
species: 645712

127205
type: SpeciesReference
stoichiometry: 1.0
species: 645037

127181
type: SpeciesReference
stoichiometry: 1.0
species: 645511

645511
type: Species
notes: FORMULA: C27H31N9O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Flavin adenine dinucleotide oxidized

647698
type: Reaction
name: 3-hydroxyacyl-CoA dehydrogenase (2-Methylacetoacetyl-CoA), mitochondrial
product: 056235
product: 056247
reactant: 056198
kinetic law: 056260
reactant: 056210
product: 056223
fast: false
reversible: true
notes: GENE_ASSOCIATION: (3028.1) GENE_LIST: 3028.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism

056235
type: SpeciesReference
stoichiometry: 1.0
species: 645716

056247
type: SpeciesReference
stoichiometry: 1.0
species: 646006

056198
type: SpeciesReference
stoichiometry: 1.0
species: 644728

654302
type: LocalParameter
units: 032971
value: 0.0

654300
type: LocalParameter
value: 0.0

654298
type: LocalParameter
units: 033007
value: 1000.0

654296
type: LocalParameter
units: 033007
value: -1000.0

056210
type: SpeciesReference
stoichiometry: 1.0
species: 645998

056223
type: SpeciesReference
stoichiometry: 1.0
species: 644683

644683
type: Species
notes: FORMULA: C26H38N7O18P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 2-Methyl-3-acetoacetyl-CoA

648682
type: Reaction
product: 092141
fast: false
reactant: 092129
reactant: 092116
reversible: false
name: sphingoid base-phosphate phosphatase (sphinganine 1-phosphatase), endoplasmic reticulum
notes: GENE_ASSOCIATION: (81537.1) GENE_LIST: 81537.1 SUBSYSTEM: Sphingolipid Metabolism
kinetic law: 092166
product: 092154

092141
type: SpeciesReference
stoichiometry: 1.0
species: 646199

092129
type: SpeciesReference
stoichiometry: 1.0
species: 646357

092116
type: SpeciesReference
stoichiometry: 1.0
species: 645707

658091
type: LocalParameter
units: 032971
value: 500.0

658090
type: LocalParameter
value: 0.0

658089
type: LocalParameter
units: 033007
value: 1000.0

658088
type: LocalParameter
units: 033007
value: 0.0

092154
type: SpeciesReference
stoichiometry: 1.0
species: 646349

646349
type: Species
notes: FORMULA: C18H38NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Sphingosine

645497
type: Species
notes: FORMULA: RH2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Electron transfer flavoprotein reduced

646978
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: mthgxl_b

647998
type: Reaction
fast: false
product: 068157
reversible: false
kinetic law: 068169
notes: GENE_ASSOCIATION: (570.1) GENE_LIST: 570.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 068132
product: 068145
reactant: 068120
name: bile acid Coenzyme A: amino acid N-acyltransferase

068157
type: SpeciesReference
stoichiometry: 1.0
species: 645581

645581
type: Species
notes: FORMULA: C26H43NO5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: glycochenodeoxycholate

655755
type: LocalParameter
units: 032971
value: 500.0

655753
type: LocalParameter
value: 0.0

655751
type: LocalParameter
units: 033007
value: 1000.0

655749
type: LocalParameter
units: 033007
value: 0.0

068132
type: SpeciesReference
stoichiometry: 1.0
species: 645632

645632
type: Species
notes: FORMULA: C2H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Glycine

068145
type: SpeciesReference
stoichiometry: 1.0
species: 645227

068120
type: SpeciesReference
stoichiometry: 1.0
species: 645299

648517
type: Reaction
name: Acetylcholinesterase
fast: false
product: 086327
reversible: false
reactant: 086290
notes: GENE_ASSOCIATION: (43.1) or (43.2) GENE_LIST: 43.1 43.2 SUBSYSTEM: Glycerophospholipid Metabolism
product: 086339
reactant: 086303
kinetic law: 086351
product: 086315

086327
type: SpeciesReference
stoichiometry: 1.0
species: 645164

086290
type: SpeciesReference
stoichiometry: 1.0
species: 644959

644959
type: Species
notes: FORMULA: C7H16NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Acetylcholine

086339
type: SpeciesReference
stoichiometry: 1.0
species: 645713

086303
type: SpeciesReference
stoichiometry: 1.0
species: 645701

657598
type: LocalParameter
units: 032971
value: 500.0

657597
type: LocalParameter
value: 0.0

657596
type: LocalParameter
units: 033007
value: 1000.0

657595
type: LocalParameter
units: 033007
value: 0.0

086315
type: SpeciesReference
stoichiometry: 1.0
species: 644924

644924
type: Species
notes: FORMULA: C2H3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Acetate

646034
type: Species
notes: FORMULA: C11H13NO6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinate D-ribonucleoside

646634
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 7-alpha,24(S)-Dihydroxycholesterol

033055
type: SBMLUnitsDef
unit: 033067
name: hours

033067
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

646121
type: Species
notes: FORMULA: C3H5O4PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: phosphatidic acid (homo sapiens)

644782
type: Species
notes: FORMULA: C6H9O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 4-Methyl-2-oxopentanoate

648688
type: Reaction
notes: GENE_ASSOCIATION: (9615.1) GENE_LIST: 9615.1 SUBSYSTEM: Purine Catabolism
reactant: 092288
product: 092300
reactant: 092264
reactant: 092276
fast: false
product: 092312
name: guanine deaminase
kinetic law: 092324
reversible: false

092288
type: SpeciesReference
stoichiometry: 1.0
species: 645712

092300
type: SpeciesReference
stoichiometry: 1.0
species: 646027

092264
type: SpeciesReference
stoichiometry: 1.0
species: 645680

645680
type: Species
notes: FORMULA: C5H5N5O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Guanine

092276
type: SpeciesReference
stoichiometry: 1.0
species: 645700

092312
type: SpeciesReference
stoichiometry: 1.0
species: 646601

658101
type: LocalParameter
units: 032971
value: 500.0

658100
type: LocalParameter
value: 0.0

658099
type: LocalParameter
units: 033007
value: 1000.0

658097
type: LocalParameter
units: 033007
value: 0.0

646631
type: Species
notes: FORMULA: C27H45XCO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: cholesterol ester

647537
type: Reaction
reversible: false
product: 049589
name: AAPSAS
reactant: 049577
notes: SUBSYSTEM: Lysine Metabolism
kinetic law: 049601
fast: false
reactant: 049565
reactant: 049553

049589
type: SpeciesReference
stoichiometry: 1.0
species: 644867

644867
type: Species
notes: FORMULA: C6H11NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-2-Aminoadipate 6-semialdehyde

049577
type: SpeciesReference
stoichiometry: 1.0
species: 646477

646477
type: Species
notes: FORMULA: C6H8NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2,3,4,5-Tetrahydropyridine-2-carboxylate

653523
type: LocalParameter
units: 032971
value: 500.0

653520
type: LocalParameter
value: 0.0

653517
type: LocalParameter
units: 033007
value: 1000.0

653514
type: LocalParameter
units: 033007
value: 0.0

049565
type: SpeciesReference
stoichiometry: 1.0
species: 645712

049553
type: SpeciesReference
stoichiometry: 1.0
species: 645700

645824
type: Species
notes: FORMULA: C5H9O7P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Isopentenyl diphosphate

645578
type: Species
notes: FORMULA: C26H43NO5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: glycochenodeoxycholate

646771
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 4nphsf_b

646798
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: adp_b

650225
type: Reaction
reversible: false
name: beta-Aminopropion aldehyde:NAD+ oxidoreductase
notes: GENE_ASSOCIATION: (8854.2) or (501.1) or (216.1) or (224.1) or (8854.3) or (223.1) or (8854.1) GENE_LIST: 216.1 223.1 224.1 501.1 8854.1 8854.2 8854.3 SUBSYSTEM: beta-Alanine metabolism
reactant: 123724
kinetic law: 123773
product: 123760
fast: false
reactant: 123700
product: 123748
reactant: 123712
product: 123736

123724
type: SpeciesReference
stoichiometry: 1.0
species: 645995

660980
type: LocalParameter
units: 032971
value: 500.0

660979
type: LocalParameter
value: 0.0

660977
type: LocalParameter
units: 033007
value: 1000.0

660976
type: LocalParameter
units: 033007
value: 0.0

123760
type: SpeciesReference
stoichiometry: 1.0
species: 646004

123700
type: SpeciesReference
stoichiometry: 1.0
species: 645100

123748
type: SpeciesReference
stoichiometry: 2.0
species: 645712

123712
type: SpeciesReference
stoichiometry: 1.0
species: 645700

123736
type: SpeciesReference
stoichiometry: 1.0
species: 645013

645665
type: Species
notes: FORMULA: C20H30N6O12S2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Oxidized glutathione

645580
type: Species
notes: FORMULA: C26H43NO5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: glycochenodeoxycholate

646118
type: Species
notes: FORMULA: C2O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Oxalate

647462
type: Reaction
reactant: 046736
name: alkyl glycerol phosphocholine acetyl transferase
product: 046760
product: 046772
fast: false
reversible: false
reactant: 046748
kinetic law: 046784
notes: SUBSYSTEM: Glycerophospholipid Metabolism

046736
type: SpeciesReference
stoichiometry: 1.0
species: 644939

046760
type: SpeciesReference
stoichiometry: 1.0
species: 645223

046772
type: SpeciesReference
stoichiometry: 1.0
species: 646129

646129
type: Species
notes: FORMULA: C11H23O4NPFULLRCO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens)

046748
type: SpeciesReference
stoichiometry: 1.0
species: 645007

645007
type: Species
notes: FORMULA: C10H21O5NPFULLR
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1-alkyl 2-lysoglycerol 3-phosphocholine

653057
type: LocalParameter
units: 032971
value: 500.0

653054
type: LocalParameter
value: 0.0

653051
type: LocalParameter
units: 033007
value: 1000.0

653048
type: LocalParameter
units: 033007
value: 0.0

648308
type: Reaction
kinetic law: 078109
product: 078097
reactant: 078085
notes: GENE_ASSOCIATION: (7167.1) or (286016.1) GENE_LIST: 286016.1 7167.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: triose-phosphate isomerase

656866
type: LocalParameter
units: 032971
value: 0.0

656865
type: LocalParameter
value: 0.0

656864
type: LocalParameter
units: 033007
value: 1000.0

656863
type: LocalParameter
units: 033007
value: -1000.0

078097
type: SpeciesReference
stoichiometry: 1.0
species: 645560

078085
type: SpeciesReference
stoichiometry: 1.0
species: 645350

645350
type: Species
notes: FORMULA: C3H5O6P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Dihydroxyacetone phosphate

647750
type: Reaction
fast: false
reactant: 058457
product: 058469
reactant: 058443
notes: GENE_ASSOCIATION: (3635.1) or (8867.2) or (3636.1) or (27124.2) or (8867.1) or (27124.1) or (3633.1) or (56623.1) or (3632.1) GENE_LIST: 27124.1 27124.2 3632.1 3633.1 3635.1 3636.1 56623.1 8867.1 8867.2 SUBSYSTEM: Inositol Phosphate Metabolism
name: inositol-1,4,5-trisphosphate 5-phosphatase
reversible: false
kinetic law: 058493
product: 058481

058457
type: SpeciesReference
stoichiometry: 1.0
species: 645965

058469
type: SpeciesReference
stoichiometry: 1.0
species: 645967

645967
type: Species
notes: FORMULA: C6H10O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 1,4-bisphosphate

058443
type: SpeciesReference
stoichiometry: 1.0
species: 645700

654547
type: LocalParameter
units: 032971
value: 500.0

654545
type: LocalParameter
value: 0.0

654543
type: LocalParameter
units: 033007
value: 1000.0

654541
type: LocalParameter
units: 033007
value: 0.0

058481
type: SpeciesReference
stoichiometry: 1.0
species: 646193

648982
type: Reaction
notes: GENE_ASSOCIATION: (1593.1) GENE_LIST: 1593.1 SUBSYSTEM: Bile Acid Biosynthesis
kinetic law: 099332
name: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase
reactant: 099248
product: 099308
product: 099320
product: 099296
reactant: 099272
reactant: 099260
reactant: 099284
reversible: false
fast: false

658702
type: LocalParameter
units: 032971
value: 500.0

658701
type: LocalParameter
value: 0.0

658699
type: LocalParameter
units: 033007
value: 1000.0

658698
type: LocalParameter
units: 033007
value: 0.0

099248
type: SpeciesReference
stoichiometry: 1.0
species: 645716

099308
type: SpeciesReference
stoichiometry: 1.0
species: 646013

099320
type: SpeciesReference
stoichiometry: 1.0
species: 646633

646633
type: Species
notes: FORMULA: C27H48O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane

099296
type: SpeciesReference
stoichiometry: 1.0
species: 645704

099272
type: SpeciesReference
stoichiometry: 1.0
species: 646061

646061
type: Species
notes: FORMULA: O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: O2

099260
type: SpeciesReference
stoichiometry: 1.0
species: 646019

099284
type: SpeciesReference
stoichiometry: 1.0
species: 646649

646649
type: Species
notes: FORMULA: C27H48O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane

645343
type: Species
notes: FORMULA: C10H13N5O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Deoxyguanosine

647020
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: pro_DASH_L_b

645338
type: Species
notes: FORMULA: C10H12N5O10P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dGDP

645253
type: Species
notes: FORMULA: C22H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: cervonic acid, C22:6 n-3

645340
type: Species
notes: FORMULA: C10H12N5O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dGMP

647097
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ura_b

648523
type: Reaction
fast: false
name: succinate-semialdehyde dehydrogenase (NAD) reversible (mitochondrial)
reactant: 086544
product: 086592
product: 086580
product: 086568
notes: GENE_ASSOCIATION: (7915.1) or (7915.2) GENE_LIST: 7915.1 7915.2 SUBSYSTEM: Glutamate metabolism
reversible: false
reactant: 086556
kinetic law: 086604
reactant: 086532

086544
type: SpeciesReference
stoichiometry: 1.0
species: 645998

086592
type: SpeciesReference
stoichiometry: 1.0
species: 646390

086580
type: SpeciesReference
stoichiometry: 1.0
species: 646006

086568
type: SpeciesReference
stoichiometry: 2.0
species: 645716

086556
type: SpeciesReference
stoichiometry: 1.0
species: 646394

657619
type: LocalParameter
units: 032971
value: 500.0

657618
type: LocalParameter
value: 0.0

657617
type: LocalParameter
units: 033007
value: 1000.0

657616
type: LocalParameter
units: 033007
value: 0.0

086532
type: SpeciesReference
stoichiometry: 1.0
species: 645704

648023
type: Reaction
reversible: false
reactant: 069131
product: 069168
fast: false
name: C-3 sterol dehydrogenase (4-methylzymosterol)
product: 069144
product: 069180
kinetic law: 069192
notes: GENE_ASSOCIATION: (50814.1) GENE_LIST: 50814.1 SUBSYSTEM: Cholesterol Metabolism
product: 069156
reactant: 069119

069131
type: SpeciesReference
stoichiometry: 1.0
species: 646015

069168
type: SpeciesReference
stoichiometry: 1.0
species: 645719

069144
type: SpeciesReference
stoichiometry: 1.0
species: 644788

069180
type: SpeciesReference
stoichiometry: 1.0
species: 646021

655869
type: LocalParameter
units: 032971
value: 500.0

655867
type: LocalParameter
value: 0.0

655865
type: LocalParameter
units: 033007
value: 1000.0

655864
type: LocalParameter
units: 033007
value: 0.0

069156
type: SpeciesReference
stoichiometry: 1.0
species: 645217

069119
type: SpeciesReference
stoichiometry: 1.0
species: 644786

644786
type: Species
notes: FORMULA: C29H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 4-Methylzymosterol intermediate 1

646204
type: Species
notes: FORMULA: C37H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Palmitoyl-CoA (n-C16:0CoA)

647258
type: Reaction
product: 038678
name: phosphatidylinositol-3-phosphate 3-phosphatase
reactant: 038654
reversible: false
reactant: 038642
fast: false
kinetic law: 038690
notes: GENE_ASSOCIATION: (8897.2) or (8897.3) or (8897.1) GENE_LIST: 8897.1 8897.2 8897.3 SUBSYSTEM: Inositol Phosphate Metabolism
product: 038666

038678
type: SpeciesReference
stoichiometry: 1.0
species: 646193

038654
type: SpeciesReference
stoichiometry: 1.0
species: 646136

646136
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1-Phosphatidyl-1D-myo-inositol 3-phosphate (Homo sapiens)

038642
type: SpeciesReference
stoichiometry: 1.0
species: 645700

651725
type: LocalParameter
units: 032971
value: 500.0

651722
type: LocalParameter
value: 0.0

651719
type: LocalParameter
units: 033007
value: 1000.0

651718
type: LocalParameter
units: 033007
value: 0.0

038666
type: SpeciesReference
stoichiometry: 1.0
species: 646144

646144
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: phosphatidylinositol (homo sapiens)

649255
type: Reaction
notes: GENE_ASSOCIATION: (570.1) GENE_LIST: 570.1 SUBSYSTEM: Bile Acid Biosynthesis
product: 104568
reactant: 104532
product: 104556
fast: false
reactant: 104544
reversible: false
name: bile acid Coenzyme A: amino acid N-acyltransferase
kinetic law: 104580

104568
type: SpeciesReference
stoichiometry: 1.0
species: 645577

645577
type: Species
notes: FORMULA: C26H43NO6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: glycocholate

104532
type: SpeciesReference
stoichiometry: 1.0
species: 645173

645173
type: Species
notes: FORMULA: C45H70N7O20P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Choloyl-CoA

104556
type: SpeciesReference
stoichiometry: 1.0
species: 645227

104544
type: SpeciesReference
stoichiometry: 1.0
species: 645632

659174
type: LocalParameter
units: 032971
value: 500.0

659173
type: LocalParameter
value: 0.0

659171
type: LocalParameter
units: 033007
value: 1000.0

659170
type: LocalParameter
units: 033007
value: 0.0

648568
type: Reaction
kinetic law: 088550
product: 088538
reactant: 088526
notes: GENE_ASSOCIATION: (29988.1) or (6513.1) or (6515.1) or (6514.1) or (81031.1) GENE_LIST: 29988.1 6513.1 6514.1 6515.1 81031.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: galactose transport (uniport)

657778
type: LocalParameter
units: 032971
value: 0.0

657777
type: LocalParameter
value: 0.0

657776
type: LocalParameter
units: 033007
value: 1000.0

657775
type: LocalParameter
units: 033007
value: -1000.0

088538
type: SpeciesReference
stoichiometry: 1.0
species: 645568

645568
type: Species
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Galactose

088526
type: SpeciesReference
stoichiometry: 1.0
species: 645569

645569
type: Species
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: D-Galactose

646175
type: Species
notes: FORMULA: C3H2O6P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Phosphoenolpyruvate

646072
type: Species
notes: FORMULA: C4H2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Oxaloacetate

647371
type: Reaction
kinetic law: 043277
product: 043265
reactant: 043252
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: lipid, flip-flop intracellular transport

652451
type: LocalParameter
units: 032971
value: 0.0

652448
type: LocalParameter
value: 0.0

652447
type: LocalParameter
units: 033007
value: 1000.0

652444
type: LocalParameter
units: 033007
value: -1000.0

043265
type: SpeciesReference
stoichiometry: 1.0
species: 645355

645355
type: Species
notes: FORMULA: C27H45O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

043252
type: SpeciesReference
stoichiometry: 1.0
species: 645353

645353
type: Species
notes: FORMULA: C27H45O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha-Dihydroxy-5beta-cholestanate

645424
type: Species
notes: FORMULA: C10H13N2O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dTDP

646439
type: Species
notes: FORMULA: C24H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosapentaenoic acid, n-6

646746
type: Species
notes: FORMULA: C28H48O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: gamma-Tocopherol

647543
type: Reaction
notes: GENE_ASSOCIATION: (8574.1) or (231.1) or (10327.2) or (10327.1) GENE_LIST: 10327.1 10327.2 231.1 8574.1 SUBSYSTEM: Pyruvate Metabolism
name: Propane-1,2-diol:NADP+ 1-oxidoreductase
product: 049782
fast: false
reactant: 049770
kinetic law: 049806
reactant: 049758
product: 049794
reactant: 049746
reversible: false

049782
type: SpeciesReference
stoichiometry: 1.0
species: 644645

049770
type: SpeciesReference
stoichiometry: 1.0
species: 646018

653552
type: LocalParameter
units: 032971
value: 500.0

653550
type: LocalParameter
value: 0.0

653548
type: LocalParameter
units: 033007
value: 1000.0

653546
type: LocalParameter
units: 033007
value: 0.0

049758
type: SpeciesReference
stoichiometry: 1.0
species: 645850

049794
type: SpeciesReference
stoichiometry: 1.0
species: 646010

049746
type: SpeciesReference
stoichiometry: 1.0
species: 645712

645014
type: Species
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: beta-Alanine

647396
type: Reaction
name: Platelet-activating factor acetylhydrolase
kinetic law: 044227
reversible: false
product: 044215
product: 044203
reactant: 044167
reactant: 044179
product: 044191
fast: false
notes: GENE_ASSOCIATION: (7941.1) GENE_LIST: 7941.1 SUBSYSTEM: Glycerophospholipid Metabolism

652621
type: LocalParameter
units: 032971
value: 500.0

652618
type: LocalParameter
value: 0.0

652615
type: LocalParameter
units: 033007
value: 1000.0

652612
type: LocalParameter
units: 033007
value: 0.0

044215
type: SpeciesReference
stoichiometry: 1.0
species: 645713

044203
type: SpeciesReference
stoichiometry: 1.0
species: 645008

645008
type: Species
notes: FORMULA: C10H21O5NPFULLR
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 1-alkyl 2-lysoglycerol 3-phosphocholine

044167
type: SpeciesReference
stoichiometry: 1.0
species: 645701

044179
type: SpeciesReference
stoichiometry: 1.0
species: 646130

646130
type: Species
notes: FORMULA: C11H23O4NPFULLRCO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens)

044191
type: SpeciesReference
stoichiometry: 1.0
species: 644924

644717
type: Species
notes: FORMULA: C4H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-3-Amino-isobutanoate

649147
type: Reaction
kinetic law: 102382
fast: false
product: 102370
name: nucleoside-diphosphate kinase (ATP:dGDP), nuclear
product: 102358
reactant: 102334
notes: GENE_ASSOCIATION: (4831.1 and 4830.1) or (4830.2 and 4831.1) GENE_LIST: 4830.1 4830.2 4831.1 SUBSYSTEM: Nucleotides
reversible: true
reactant: 102346

658977
type: LocalParameter
units: 032971
value: 0.0

658975
type: LocalParameter
value: 0.0

658974
type: LocalParameter
units: 033007
value: 1000.0

658972
type: LocalParameter
units: 033007
value: -1000.0

102370
type: SpeciesReference
stoichiometry: 1.0
species: 645349

645349
type: Species
notes: FORMULA: C10H12N5O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dGTP

102358
type: SpeciesReference
stoichiometry: 1.0
species: 644978

102334
type: SpeciesReference
stoichiometry: 1.0
species: 645092

102346
type: SpeciesReference
stoichiometry: 1.0
species: 645338

647019
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ppa_b

644804
type: Species
notes: FORMULA: C5H9NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5-Amino-4-oxopentanoate

647447
type: Reaction
kinetic law: 046301
fast: false
product: 046265
notes: GENE_ASSOCIATION: (1629.1) and (594.1 and 593.1) and (1738.1) or (1629.1) and (1738.1) and (594.2 and 593.1) GENE_LIST: 1629.1 1738.1 593.1 594.1 594.2 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
product: 046277
reactant: 046241
reversible: false
product: 046289
reactant: 046229
name: 2-oxoisovalerate dehydrogenase (acylating; 3-methyl-2-oxopentanoate), mitochondrial
reactant: 046253

652958
type: LocalParameter
units: 032971
value: 500.0

652955
type: LocalParameter
value: 0.0

652952
type: LocalParameter
units: 033007
value: 1000.0

652951
type: LocalParameter
units: 033007
value: 0.0

046265
type: SpeciesReference
stoichiometry: 1.0
species: 644686

644686
type: Species
notes: FORMULA: C26H40N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 2-Methylbutanoyl-CoA

046277
type: SpeciesReference
stoichiometry: 1.0
species: 645215

046241
type: SpeciesReference
stoichiometry: 1.0
species: 645224

046289
type: SpeciesReference
stoichiometry: 1.0
species: 646006

046229
type: SpeciesReference
stoichiometry: 1.0
species: 644746

644746
type: Species
notes: FORMULA: C6H9O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-3-Methyl-2-oxopentanoate

046253
type: SpeciesReference
stoichiometry: 1.0
species: 645998

648679
type: Reaction
kinetic law: 092104
product: 092092
product: 092080
reactant: 092068
notes: SUBSYSTEM: Lysine Metabolism
fast: false
reversible: false
name: PPD2CSPp

658087
type: LocalParameter
units: 032971
value: 500.0

658086
type: LocalParameter
value: 0.0

658085
type: LocalParameter
units: 033007
value: 1000.0

658084
type: LocalParameter
units: 033007
value: 0.0

092092
type: SpeciesReference
stoichiometry: 1.0
species: 645709

092080
type: SpeciesReference
stoichiometry: 1.0
species: 644665

644665
type: Species
notes: FORMULA: C6H9NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: delta1-Piperideine-2-carboxylate

092068
type: SpeciesReference
stoichiometry: 1.0
species: 644840

649573
type: Reaction
kinetic law: 111103
product: 111091
reactant: 111079
notes: GENE_ASSOCIATION: (3177.1) GENE_LIST: 3177.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: thymine reversible transport via facilated diffusion

659740
type: LocalParameter
units: 032971
value: 0.0

659738
type: LocalParameter
value: 0.0

659737
type: LocalParameter
units: 033007
value: 1000.0

659735
type: LocalParameter
units: 033007
value: -1000.0

111091
type: SpeciesReference
stoichiometry: 1.0
species: 646483

646483
type: Species
notes: FORMULA: C5H6N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Thymine

111079
type: SpeciesReference
stoichiometry: 1.0
species: 646484

648754
type: Reaction
kinetic law: 093803
product: 093791
reactant: 093779
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: acetoacetate intracellular transport unknown mechanism

658226
type: LocalParameter
units: 032971
value: 0.0

658225
type: LocalParameter
value: 0.0

658224
type: LocalParameter
units: 033007
value: 1000.0

658223
type: LocalParameter
units: 033007
value: -1000.0

093791
type: SpeciesReference
stoichiometry: 1.0
species: 644932

644932
type: Species
notes: FORMULA: C4H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Acetoacetate

093779
type: SpeciesReference
stoichiometry: 1.0
species: 644927

644927
type: Species
notes: FORMULA: C4H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Acetoacetate

646849
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: cyan_b

647046
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: sphs1p_b

650555
type: Reaction
kinetic law: 132419
product: 132407
reactant: 132395
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: beta-carotene transport via diffusion

661805
type: LocalParameter
units: 032971
value: 0.0

661804
type: LocalParameter
value: 0.0

661802
type: LocalParameter
units: 033007
value: 1000.0

661801
type: LocalParameter
units: 033007
value: -1000.0

132407
type: SpeciesReference
stoichiometry: 1.0
species: 645137

645137
type: Species
notes: FORMULA: C40H56
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: beta-Carotene

132395
type: SpeciesReference
stoichiometry: 1.0
species: 645139

645139
type: Species
notes: FORMULA: C40H56
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: beta-Carotene

647453
type: Reaction
reversible: false
fast: false
reactant: 046434
product: 046447
kinetic law: 046471
reactant: 046422
name: ethanolamine phosphate phosphatase
notes: GENE_ASSOCIATION: (162466.1) GENE_LIST: 162466.1 SUBSYSTEM: Glycerophospholipid Metabolism
product: 046459

046434
type: SpeciesReference
stoichiometry: 1.0
species: 645700

046447
type: SpeciesReference
stoichiometry: 1.0
species: 645499

645499
type: Species
notes: FORMULA: C2H8NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Ethanolamine

652997
type: LocalParameter
units: 032971
value: 500.0

652994
type: LocalParameter
value: 0.0

652991
type: LocalParameter
units: 033007
value: 1000.0

652988
type: LocalParameter
units: 033007
value: 0.0

046422
type: SpeciesReference
stoichiometry: 1.0
species: 645500

645500
type: Species
notes: FORMULA: C2H7NO4P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Ethanolamine phosphate

046459
type: SpeciesReference
stoichiometry: 1.0
species: 646193

649273
type: Reaction
name: dihydroceramide desaturase
reactant: 104846
notes: GENE_ASSOCIATION: (8560.1) or (8560.2) GENE_LIST: 8560.1 8560.2 SUBSYSTEM: Sphingolipid Metabolism
product: 104870
product: 104894
fast: false
reversible: false
kinetic law: 104906
product: 104882
reactant: 104858

104846
type: SpeciesReference
stoichiometry: 1.0
species: 645359

645359
type: Species
notes: FORMULA: C18H38NO2FULLRCO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dihydroceramide (homo sapiens)

104870
type: SpeciesReference
stoichiometry: 1.0
species: 645239

104894
type: SpeciesReference
stoichiometry: 1.0
species: 646018

659204
type: LocalParameter
units: 032971
value: 500.0

659202
type: LocalParameter
value: 0.0

659201
type: LocalParameter
units: 033007
value: 1000.0

659200
type: LocalParameter
units: 033007
value: 0.0

104882
type: SpeciesReference
stoichiometry: 1.0
species: 645712

104858
type: SpeciesReference
stoichiometry: 1.0
species: 646010

647317
type: Reaction
product: 041164
reactant: 041140
product: 041189
reactant: 041152
fast: false
notes: GENE_ASSOCIATION: (19.1) GENE_LIST: 19.1 SUBSYSTEM: Transport, Extracellular
name: cholesterol efflux (ATP depedent)
product: 041201
product: 041177
reactant: 041128
kinetic law: 041213
reversible: false

041164
type: SpeciesReference
stoichiometry: 1.0
species: 644974

041140
type: SpeciesReference
stoichiometry: 1.0
species: 645184

041189
type: SpeciesReference
stoichiometry: 1.0
species: 645712

041152
type: SpeciesReference
stoichiometry: 1.0
species: 645700

041201
type: SpeciesReference
stoichiometry: 1.0
species: 646193

041177
type: SpeciesReference
stoichiometry: 1.0
species: 645185

645185
type: Species
notes: FORMULA: C27H46O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Cholesterol

041128
type: SpeciesReference
stoichiometry: 1.0
species: 645088

652093
type: LocalParameter
units: 032971
value: 500.0

652090
type: LocalParameter
value: 0.0

652087
type: LocalParameter
units: 033007
value: 1000.0

652084
type: LocalParameter
units: 033007
value: 0.0

646996
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ocdcea_b

649408
type: Reaction
product: 107641
fast: false
reversible: false
reactant: 107629
notes: GENE_ASSOCIATION: (8897.1) or (8897.3) or (8897.2) GENE_LIST: 8897.1 8897.2 8897.3 SUBSYSTEM: Inositol Phosphate Metabolism
kinetic law: 107665
name: phosphatidylinositol-3,5-bisphosphate 3-phosphatase
reactant: 107617
product: 107653

107641
type: SpeciesReference
stoichiometry: 1.0
species: 646142

646142
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)

107629
type: SpeciesReference
stoichiometry: 1.0
species: 646135

646135
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)

659438
type: LocalParameter
units: 032971
value: 500.0

659437
type: LocalParameter
value: 0.0

659435
type: LocalParameter
units: 033007
value: 1000.0

659434
type: LocalParameter
units: 033007
value: 0.0

107617
type: SpeciesReference
stoichiometry: 1.0
species: 645700

107653
type: SpeciesReference
stoichiometry: 1.0
species: 646193

647803
type: Reaction
kinetic law: 060476
product: 060464
product: 060452
reactant: 060440
notes: GENE_ASSOCIATION: (3034.1) GENE_LIST: 3034.1 SUBSYSTEM: Histidine Metabolism
fast: false
reversible: false
name: histidase

654792
type: LocalParameter
units: 032971
value: 500.0

654790
type: LocalParameter
value: 0.0

654788
type: LocalParameter
units: 033007
value: 1000.0

654786
type: LocalParameter
units: 033007
value: 0.0

060464
type: SpeciesReference
stoichiometry: 1.0
species: 646564

646564
type: Species
notes: FORMULA: C6H5N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Urocanate

060452
type: SpeciesReference
stoichiometry: 1.0
species: 646027

060440
type: SpeciesReference
stoichiometry: 1.0
species: 645769

645769
type: Species
notes: FORMULA: C6H9N3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Histidine

646818
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: asn_DASH_L_b

648475
type: Reaction
notes: GENE_ASSOCIATION: (10935.1) or (2879.1) or (10935.2) GENE_LIST: 10935.1 10935.2 2879.1 SUBSYSTEM: Glutathione Metabolism
name: glutathione peroxidase, mitochondria
product: 084600
kinetic law: 084624
reactant: 084576
product: 084612
reversible: true
reactant: 084588
fast: false

084600
type: SpeciesReference
stoichiometry: 1.0
species: 645668

645668
type: Species
notes: FORMULA: C20H30N6O12S2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Oxidized glutathione

657485
type: LocalParameter
units: 032971
value: 0.0

657484
type: LocalParameter
value: 0.0

657483
type: LocalParameter
units: 033007
value: 1000.0

657482
type: LocalParameter
units: 033007
value: -1000.0

084576
type: SpeciesReference
stoichiometry: 2.0
species: 645673

645673
type: Species
notes: FORMULA: C10H16N3O6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Reduced glutathione

084612
type: SpeciesReference
stoichiometry: 2.0
species: 645704

084588
type: SpeciesReference
stoichiometry: 1.0
species: 645697

645697
type: Species
notes: FORMULA: H2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Hydrogen peroxide

647774
type: Reaction
kinetic law: 059462
product: 059450
reactant: 059438
fast: false
reversible: true
name: Uridine exchange

654659
type: LocalParameter
units: 032971
value: 0.0

654657
type: LocalParameter
value: 0.0

654655
type: LocalParameter
units: 033007
value: 1000.0

654653
type: LocalParameter
units: 033007
value: -1000.0

059450
type: SpeciesReference
stoichiometry: 1.0
species: 646833

646833
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: caro_b

059438
type: SpeciesReference
stoichiometry: 1.0
species: 646571

646571
type: Species
notes: FORMULA: C9H12N2O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Uridine

647848
type: Reaction
reversible: false
fast: false
reactant: 062241
reactant: 062229
kinetic law: 062278
product: 062254
notes: SUBSYSTEM: Transport, Mitochondrial
product: 062266
name: 3-Methyl-2-oxopentanoate mitochondrial transport via proton symport

062241
type: SpeciesReference
stoichiometry: 1.0
species: 645712

062229
type: SpeciesReference
stoichiometry: 1.0
species: 644744

644744
type: Species
notes: FORMULA: C6H9O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (S)-3-Methyl-2-oxopentanoate

655002
type: LocalParameter
units: 032971
value: 500.0

655000
type: LocalParameter
value: 0.0

654998
type: LocalParameter
units: 033007
value: 1000.0

654996
type: LocalParameter
units: 033007
value: 0.0

062254
type: SpeciesReference
stoichiometry: 1.0
species: 644746

062266
type: SpeciesReference
stoichiometry: 1.0
species: 645716

646905
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: glyb_b

649729
type: Reaction
reactant: 113999
fast: false
product: 114036
reversible: false
notes: GENE_ASSOCIATION: (4548.1) GENE_LIST: 4548.1 SUBSYSTEM: Methionine Metabolism
product: 114024
kinetic law: 114048
name: methionine synthase
reactant: 113987
product: 114011

113999
type: SpeciesReference
stoichiometry: 1.0
species: 645737

645737
type: Species
notes: FORMULA: C4H9NO2S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Homocysteine

114036
type: SpeciesReference
stoichiometry: 1.0
species: 646460

114024
type: SpeciesReference
stoichiometry: 1.0
species: 645953

645953
type: Species
notes: FORMULA: C5H11NO2S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Methionine

660021
type: LocalParameter
units: 032971
value: 500.0

660020
type: LocalParameter
value: 0.0

660018
type: LocalParameter
units: 033007
value: 1000.0

660017
type: LocalParameter
units: 033007
value: 0.0

113987
type: SpeciesReference
stoichiometry: 1.0
species: 644828

114011
type: SpeciesReference
stoichiometry: 1.0
species: 645712

650734
type: Reaction
kinetic law: 138117
product: 138105
reactant: 138093
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport

662296
type: LocalParameter
units: 032971
value: 0.0

662295
type: LocalParameter
value: 0.0

662293
type: LocalParameter
units: 033007
value: 1000.0

662292
type: LocalParameter
units: 033007
value: -1000.0

138105
type: SpeciesReference
stoichiometry: 1.0
species: 644789

644789
type: Species
notes: FORMULA: C6H5NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4-Nitrophenol

138093
type: SpeciesReference
stoichiometry: 1.0
species: 644791

644791
type: Species
notes: FORMULA: C6H5NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 4-Nitrophenol

650606
type: Reaction
product: 133937
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
kinetic law: 133985
product: 133961
reactant: 133925
reversible: false
reactant: 133901
reactant: 133913
name: folylpolyglutamate synthetase, mitochondrial
product: 133973
fast: false
product: 133949

133937
type: SpeciesReference
stoichiometry: 1.0
species: 644854

661943
type: LocalParameter
units: 032971
value: 500.0

661941
type: LocalParameter
value: 0.0

661940
type: LocalParameter
units: 033007
value: 1000.0

661938
type: LocalParameter
units: 033007
value: 0.0

133961
type: SpeciesReference
stoichiometry: 1.0
species: 645716

133925
type: SpeciesReference
stoichiometry: 1.0
species: 645616

133901
type: SpeciesReference
stoichiometry: 1.0
species: 644839

133913
type: SpeciesReference
stoichiometry: 1.0
species: 645091

133973
type: SpeciesReference
stoichiometry: 1.0
species: 646196

133949
type: SpeciesReference
stoichiometry: 1.0
species: 644977

648601
type: Reaction
reactant: 089832
reversible: true
kinetic law: 089880
reactant: 089844
product: 089868
notes: GENE_ASSOCIATION: (7086.1) or (84076.1) or (8277.1) GENE_LIST: 7086.1 8277.1 84076.1 SUBSYSTEM: Pentose Phosphate Pathway
fast: false
product: 089856
name: transketolase

089832
type: SpeciesReference
stoichiometry: 1.0
species: 646292

646292
type: Species
notes: FORMULA: C5H9O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: alpha-D-Ribose 5-phosphate

657890
type: LocalParameter
units: 032971
value: 0.0

657889
type: LocalParameter
value: 0.0

657888
type: LocalParameter
units: 033007
value: 1000.0

657887
type: LocalParameter
units: 033007
value: -1000.0

089844
type: SpeciesReference
stoichiometry: 1.0
species: 646654

646654
type: Species
notes: FORMULA: C5H9O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Xylulose 5-phosphate

089868
type: SpeciesReference
stoichiometry: 1.0
species: 646321

646321
type: Species
notes: FORMULA: C7H13O10P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Sedoheptulose 7-phosphate

089856
type: SpeciesReference
stoichiometry: 1.0
species: 645560

646481
type: Species
notes: FORMULA: C4H9NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Threonine

649630
type: Reaction
kinetic law: 112056
product: 112044
reactant: 112031
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: lipid, flip-flop intracellular transport

659842
type: LocalParameter
units: 032971
value: 0.0

659841
type: LocalParameter
value: 0.0

659839
type: LocalParameter
units: 033007
value: 1000.0

659838
type: LocalParameter
units: 033007
value: -1000.0

112044
type: SpeciesReference
stoichiometry: 1.0
species: 646649

112031
type: SpeciesReference
stoichiometry: 1.0
species: 646648

645229
type: Species
notes: FORMULA: C21H28O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Cortisone

644968
type: Species
notes: FORMULA: C5H5N5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Adenine

645451
type: Species
notes: FORMULA: C48H81O41X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: phosphorylase-limit dextrin (glycogenin-1,6{4[1,4-Glc], 4[1,4-Glc]})

649033
type: Reaction
fast: false
name: phosphatidylinositol synthase (Homo sapiens)
reactant: 100273
product: 100309
notes: GENE_ASSOCIATION: (10423.2) or (10423.1) GENE_LIST: 10423.1 10423.2 SUBSYSTEM: Glycerophospholipid Metabolism
product: 100321
reversible: true
reactant: 100285
product: 100297
kinetic law: 100333

100273
type: SpeciesReference
stoichiometry: 1.0
species: 645154

645154
type: Species
notes: FORMULA: C12H17N3O11P2FULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: CDP diacylglycerol (homo sapiens)

100309
type: SpeciesReference
stoichiometry: 1.0
species: 645712

100321
type: SpeciesReference
stoichiometry: 1.0
species: 646144

100285
type: SpeciesReference
stoichiometry: 1.0
species: 645817

100297
type: SpeciesReference
stoichiometry: 1.0
species: 645205

645205
type: Species
notes: FORMULA: C9H12N3O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: CMP

658779
type: LocalParameter
units: 032971
value: 0.0

658778
type: LocalParameter
value: 0.0

658777
type: LocalParameter
units: 033007
value: 1000.0

658776
type: LocalParameter
units: 033007
value: -1000.0

648946
type: Reaction
product: 098474
reversible: false
fast: false
name: carnitine transferase
product: 098486
reactant: 098450
reactant: 098462
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
kinetic law: 098498

098474
type: SpeciesReference
stoichiometry: 1.0
species: 645247

098486
type: SpeciesReference
stoichiometry: 1.0
species: 645394

098450
type: SpeciesReference
stoichiometry: 1.0
species: 645224

098462
type: SpeciesReference
stoichiometry: 1.0
species: 645397

645397
type: Species
notes: FORMULA: C27H47NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: dihomo-gamma-linolenyl carnitine

658646
type: LocalParameter
units: 032971
value: 500.0

658645
type: LocalParameter
value: 0.0

658644
type: LocalParameter
units: 033007
value: 1000.0

658643
type: LocalParameter
units: 033007
value: 0.0

647666
type: Reaction
kinetic law: 054923
name: valine transaminase, mitochondiral
reversible: true
fast: false
product: 054911
reactant: 054875
notes: GENE_ASSOCIATION: (587.1) GENE_LIST: 587.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
product: 054899
reactant: 054887

654155
type: LocalParameter
units: 032971
value: 0.0

654153
type: LocalParameter
value: 0.0

654151
type: LocalParameter
units: 033007
value: 1000.0

654149
type: LocalParameter
units: 033007
value: -1000.0

054911
type: SpeciesReference
stoichiometry: 1.0
species: 645616

054875
type: SpeciesReference
stoichiometry: 1.0
species: 645011

054899
type: SpeciesReference
stoichiometry: 1.0
species: 644743

054887
type: SpeciesReference
stoichiometry: 1.0
species: 646591

646591
type: Species
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Valine

647249
type: Reaction
product: 038281
fast: false
name: 5'-nucleotidase (XMP)
product: 038293
reversible: false
kinetic law: 038305
notes: GENE_ASSOCIATION: (22978.1) GENE_LIST: 22978.1 SUBSYSTEM: Nucleotides
reactant: 038269
reactant: 038257

038281
type: SpeciesReference
stoichiometry: 1.0
species: 646193

038293
type: SpeciesReference
stoichiometry: 1.0
species: 646651

651669
type: LocalParameter
units: 032971
value: 500.0

651666
type: LocalParameter
value: 0.0

651663
type: LocalParameter
units: 033007
value: 1000.0

651660
type: LocalParameter
units: 033007
value: 0.0

038269
type: SpeciesReference
stoichiometry: 1.0
species: 646604

646604
type: Species
notes: FORMULA: C10H11N4O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Xanthosine 5'-phosphate

038257
type: SpeciesReference
stoichiometry: 1.0
species: 645700

647608
type: Reaction
reactant: 052390
product: 052414
kinetic law: 052438
name: UMP kinase (dCTP)
fast: false
reactant: 052402
product: 052426
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
reversible: true

052390
type: SpeciesReference
stoichiometry: 1.0
species: 645314

645314
type: Species
notes: FORMULA: C9H12N3O13P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dCTP

052414
type: SpeciesReference
stoichiometry: 1.0
species: 645295

653882
type: LocalParameter
units: 032971
value: 0.0

653880
type: LocalParameter
value: 0.0

653878
type: LocalParameter
units: 033007
value: 1000.0

653876
type: LocalParameter
units: 033007
value: -1000.0

052402
type: SpeciesReference
stoichiometry: 1.0
species: 646549

052426
type: SpeciesReference
stoichiometry: 1.0
species: 646535

648697
type: Reaction
name: choline phosphate cytididyltransferase
reactant: 092528
kinetic law: 092564
notes: GENE_ASSOCIATION: (5130.1) or (9468.1) GENE_LIST: 5130.1 9468.1 SUBSYSTEM: Glycerophospholipid Metabolism
fast: false
reversible: false
reactant: 092516
product: 092552
reactant: 092504
product: 092540

092528
type: SpeciesReference
stoichiometry: 1.0
species: 645712

658117
type: LocalParameter
units: 032971
value: 500.0

658116
type: LocalParameter
value: 0.0

658115
type: LocalParameter
units: 033007
value: 1000.0

658114
type: LocalParameter
units: 033007
value: 0.0

092516
type: SpeciesReference
stoichiometry: 1.0
species: 645254

092552
type: SpeciesReference
stoichiometry: 1.0
species: 646222

092504
type: SpeciesReference
stoichiometry: 1.0
species: 645181

645181
type: Species
notes: FORMULA: C5H13NO4P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Choline phosphate

092540
type: SpeciesReference
stoichiometry: 1.0
species: 645152

645152
type: Species
notes: FORMULA: C14H25N4O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: CDPcholine

647420
type: Reaction
kinetic law: 045159
product: 045147
reversible: false
reactant: 045111
product: 045135
notes: GENE_ASSOCIATION: (2184.1) GENE_LIST: 2184.1 SUBSYSTEM: Tyrosine metabolism
name: fumarylacetoacetase
fast: false
product: 045123
reactant: 045099

652781
type: LocalParameter
units: 032971
value: 500.0

652778
type: LocalParameter
value: 0.0

652775
type: LocalParameter
units: 033007
value: 1000.0

652772
type: LocalParameter
units: 033007
value: 0.0

045147
type: SpeciesReference
stoichiometry: 1.0
species: 645712

045111
type: SpeciesReference
stoichiometry: 1.0
species: 645700

045135
type: SpeciesReference
stoichiometry: 1.0
species: 645556

045123
type: SpeciesReference
stoichiometry: 1.0
species: 644927

045099
type: SpeciesReference
stoichiometry: 1.0
species: 644767

644767
type: Species
notes: FORMULA: C8H6O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4-Fumarylacetoacetate

650626
type: Reaction
kinetic law: 134580
product: 134568
product: 134556
reactant: 134544
notes: GENE_ASSOCIATION: (226.2) or (226.1) or (226.3) or (230.1) or (229.1) GENE_LIST: 226.1 226.2 226.3 229.1 230.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
fast: false
reversible: true
name: fructose-bisphosphate aldolase

661998
type: LocalParameter
units: 032971
value: 0.0

661996
type: LocalParameter
value: 0.0

661995
type: LocalParameter
units: 033007
value: 1000.0

661993
type: LocalParameter
units: 033007
value: -1000.0

134568
type: SpeciesReference
stoichiometry: 1.0
species: 645560

134556
type: SpeciesReference
stoichiometry: 1.0
species: 645350

134544
type: SpeciesReference
stoichiometry: 1.0
species: 645527

645527
type: Species
notes: FORMULA: C6H10O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Fructose 1,6-bisphosphate

648053
type: Reaction
kinetic law: 070498
product: 070486
reactant: 070474
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: Octanoate transport via diffusion

656008
type: LocalParameter
units: 032971
value: 0.0

656006
type: LocalParameter
value: 0.0

656004
type: LocalParameter
units: 033007
value: 1000.0

656002
type: LocalParameter
units: 033007
value: -1000.0

070486
type: SpeciesReference
stoichiometry: 1.0
species: 646085

646085
type: Species
notes: FORMULA: C8H15O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: octanoate (n-C8:0)

070474
type: SpeciesReference
stoichiometry: 1.0
species: 646087

647966
type: Reaction
kinetic law: 067008
notes: GENE_ASSOCIATION: (6319.1) GENE_LIST: 6319.1 SUBSYSTEM: Fatty acid elongation
fast: false
product: 066996
reactant: 066947
product: 066972
product: 066984
reactant: 066960
reversible: false
reactant: 066923
reactant: 066935
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

655555
type: LocalParameter
units: 032971
value: 500.0

655553
type: LocalParameter
value: 0.0

655551
type: LocalParameter
units: 033007
value: 1000.0

655549
type: LocalParameter
units: 033007
value: 0.0

066996
type: SpeciesReference
stoichiometry: 1.0
species: 646582

066947
type: SpeciesReference
stoichiometry: 1.0
species: 646060

066972
type: SpeciesReference
stoichiometry: 2.0
species: 645700

066984
type: SpeciesReference
stoichiometry: 1.0
species: 645995

066960
type: SpeciesReference
stoichiometry: 1.0
species: 646366

646366
type: Species
notes: FORMULA: C39H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Stearoyl-CoA (n-C18:0CoA)

066923
type: SpeciesReference
stoichiometry: 1.0
species: 645712

066935
type: SpeciesReference
stoichiometry: 1.0
species: 646004

649219
type: Reaction
reactant: 103806
reactant: 103819
kinetic law: 103855
product: 103843
notes: GENE_ASSOCIATION: (5053.1) GENE_LIST: 5053.1 SUBSYSTEM: Tyr, Phe, Trp Biosynthesis
fast: false
reversible: false
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
reactant: 103794
product: 103831

103806
type: SpeciesReference
stoichiometry: 1.0
species: 646184

646184
type: Species
notes: FORMULA: C9H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Phenylalanine

103819
type: SpeciesReference
stoichiometry: 1.0
species: 646453

646453
type: Species
notes: FORMULA: C9H15N5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Tetrahydrobiopterin

659107
type: LocalParameter
units: 032971
value: 500.0

659105
type: LocalParameter
value: 0.0

659104
type: LocalParameter
units: 033007
value: 1000.0

659102
type: LocalParameter
units: 033007
value: 0.0

103843
type: SpeciesReference
stoichiometry: 1.0
species: 646531

646531
type: Species
notes: FORMULA: C9H11NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Tyrosine

103794
type: SpeciesReference
stoichiometry: 1.0
species: 646060

103831
type: SpeciesReference
stoichiometry: 1.0
species: 646451

646451
type: Species
notes: FORMULA: C9H15N5O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Tetrahydrobiopterin-4a-carbinolamine

645622
type: Species
notes: FORMULA: C24H46NO7FULLRCO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: glucocerebroside (homo sapiens)

647899
type: Reaction
kinetic law: 064284
product: 064272
reactant: 064260
fast: false
reversible: true
name: Acetate exchange

655240
type: LocalParameter
units: 032971
value: 0.0

655238
type: LocalParameter
value: 0.0

655236
type: LocalParameter
units: 033007
value: 1000.0

655234
type: LocalParameter
units: 033007
value: -1000.0

064272
type: SpeciesReference
stoichiometry: 1.0
species: 646851

646851
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: cys_DASH_L_b

064260
type: SpeciesReference
stoichiometry: 1.0
species: 644924

647255
type: Reaction
reversible: false
product: 038534
reactant: 038498
reactant: 038486
fast: false
name: glycine oxidase, perixosomal
reactant: 038510
kinetic law: 038558
product: 038546
product: 038522
notes: SUBSYSTEM: Glycine, Serine, and Threonine Metabolism

038534
type: SpeciesReference
stoichiometry: 1.0
species: 645698

038498
type: SpeciesReference
stoichiometry: 1.0
species: 645709

038486
type: SpeciesReference
stoichiometry: 1.0
species: 645632

038510
type: SpeciesReference
stoichiometry: 1.0
species: 646064

651709
type: LocalParameter
units: 032971
value: 500.0

651706
type: LocalParameter
value: 0.0

651703
type: LocalParameter
units: 033007
value: 1000.0

651700
type: LocalParameter
units: 033007
value: 0.0

038546
type: SpeciesReference
stoichiometry: 1.0
species: 646033

038522
type: SpeciesReference
stoichiometry: 1.0
species: 645626

645626
type: Species
notes: FORMULA: C2H1O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Glyoxylate

646842
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: co2_b

648404
type: Reaction
product: 081833
product: 081845
name: cytidylate kinase (dCMP,dATP)
reversible: true
reactant: 081809
reactant: 081821
fast: false
kinetic law: 081857
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides

081833
type: SpeciesReference
stoichiometry: 1.0
species: 645277

645277
type: Species
notes: FORMULA: C10H12N5O9P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dADP

081845
type: SpeciesReference
stoichiometry: 1.0
species: 645295

081809
type: SpeciesReference
stoichiometry: 1.0
species: 645287

645287
type: Species
notes: FORMULA: C10H12N5O12P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dATP

081821
type: SpeciesReference
stoichiometry: 1.0
species: 645301

657294
type: LocalParameter
units: 032971
value: 0.0

657293
type: LocalParameter
value: 0.0

657292
type: LocalParameter
units: 033007
value: 1000.0

657291
type: LocalParameter
units: 033007
value: -1000.0

648239
type: Reaction
kinetic law: 076382
product: 076370
reactant: 076358
fast: false
reversible: true
name: Carbon monoxide exchange

656684
type: LocalParameter
units: 032971
value: 0.0

656682
type: LocalParameter
value: 0.0

656680
type: LocalParameter
units: 033007
value: 1000.0

656678
type: LocalParameter
units: 033007
value: -1000.0

076370
type: SpeciesReference
stoichiometry: 1.0
species: 646887

646887
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: etoh_b

076358
type: SpeciesReference
stoichiometry: 1.0
species: 645221

644812
type: Species
notes: FORMULA: C39H43N11O18
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: pentaglutamyl folate (DHF)

648410
type: Reaction
product: 082067
product: 082054
fast: false
notes: GENE_ASSOCIATION: (130.1) or (125.1) or (124.1) or (128.1) or (126.1) or (284273.2) or (126.1 and 124.1) or (127.1) or (125.1 and 124.1) or (137872.1) or (284273.1) or (125.1 and 126.1) or (131.1) GENE_LIST: 124.1 125.1 126.1 127.1 128.1 130.1 131.1 137872.1 284273.1 284273.2 SUBSYSTEM: Pyruvate Metabolism
reactant: 082041
name: alcohol dehydrogenase (L-1,2-propanediol)
kinetic law: 082093
reactant: 082028
reversible: false
product: 082080

082067
type: SpeciesReference
stoichiometry: 1.0
species: 645851

082054
type: SpeciesReference
stoichiometry: 1.0
species: 645712

082041
type: SpeciesReference
stoichiometry: 1.0
species: 645995

657310
type: LocalParameter
units: 032971
value: 500.0

657309
type: LocalParameter
value: 0.0

657308
type: LocalParameter
units: 033007
value: 1000.0

657307
type: LocalParameter
units: 033007
value: 0.0

082028
type: SpeciesReference
stoichiometry: 1.0
species: 644647

644647
type: Species
notes: FORMULA: C3H8O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (S)-Propane-1,2-diol

082080
type: SpeciesReference
stoichiometry: 1.0
species: 646004

648481
type: Reaction
kinetic law: 084902
product: 084878
product: 084865
name: NAD nucleosidase
reactant: 084853
notes: SUBSYSTEM: NAD Metabolism
fast: false
reversible: false
product: 084890
reactant: 084841

657501
type: LocalParameter
units: 032971
value: 500.0

657500
type: LocalParameter
value: 0.0

657499
type: LocalParameter
units: 033007
value: 1000.0

657498
type: LocalParameter
units: 033007
value: 0.0

084878
type: SpeciesReference
stoichiometry: 1.0
species: 645712

084865
type: SpeciesReference
stoichiometry: 1.0
species: 644983

644983
type: Species
notes: FORMULA: C15H21N5O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: ADPribose

084853
type: SpeciesReference
stoichiometry: 1.0
species: 645995

084890
type: SpeciesReference
stoichiometry: 1.0
species: 646024

646024
type: Species
notes: FORMULA: C6H6N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinamide

084841
type: SpeciesReference
stoichiometry: 1.0
species: 645700

647070
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetpent3_b

647306
type: Reaction
reactant: 040778
product: 040802
name: dGTP transport via dTDP antiport
kinetic law: 040826
reactant: 040790
fast: false
reversible: false
notes: GENE_ASSOCIATION: (60386.1) GENE_LIST: 60386.1 SUBSYSTEM: Transport, Mitochondrial
product: 040814

040778
type: SpeciesReference
stoichiometry: 1.0
species: 645346

040802
type: SpeciesReference
stoichiometry: 1.0
species: 645347

652023
type: LocalParameter
units: 032971
value: 500.0

652022
type: LocalParameter
value: 0.0

652019
type: LocalParameter
units: 033007
value: 1000.0

652018
type: LocalParameter
units: 033007
value: 0.0

040790
type: SpeciesReference
stoichiometry: 1.0
species: 645422

040814
type: SpeciesReference
stoichiometry: 1.0
species: 645421

645652
type: Species
notes: FORMULA: C66H111O56X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})

649432
type: Reaction
name: 3',5'-bisphosphate nucleotidase
notes: GENE_ASSOCIATION: (10380.1) GENE_LIST: 10380.1 SUBSYSTEM: Nucleotides
reversible: false
product: 108267
reactant: 108243
reactant: 108255
product: 108279
fast: false
kinetic law: 108291

108267
type: SpeciesReference
stoichiometry: 1.0
species: 645037

108243
type: SpeciesReference
stoichiometry: 1.0
species: 645700

108255
type: SpeciesReference
stoichiometry: 1.0
species: 646148

108279
type: SpeciesReference
stoichiometry: 1.0
species: 646193

659487
type: LocalParameter
units: 032971
value: 500.0

659486
type: LocalParameter
value: 0.0

659485
type: LocalParameter
units: 033007
value: 1000.0

659483
type: LocalParameter
units: 033007
value: 0.0

647341
type: Reaction
reactant: 042017
reactant: 042042
name: Hydroxypyruvate reductase (NADPH)
reversible: false
fast: false
notes: GENE_ASSOCIATION: (9380.1) GENE_LIST: 9380.1 SUBSYSTEM: Glyoxylate and Dicarboxylate Metabolism
product: 042054
reactant: 042029
product: 042066
kinetic law: 042078

042017
type: SpeciesReference
stoichiometry: 1.0
species: 645712

042042
type: SpeciesReference
stoichiometry: 1.0
species: 646018

042054
type: SpeciesReference
stoichiometry: 1.0
species: 645641

645641
type: Species
notes: FORMULA: C3H5O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (R)-Glycerate

042029
type: SpeciesReference
stoichiometry: 1.0
species: 645788

042066
type: SpeciesReference
stoichiometry: 1.0
species: 646010

652253
type: LocalParameter
units: 032971
value: 500.0

652250
type: LocalParameter
value: 0.0

652247
type: LocalParameter
units: 033007
value: 1000.0

652244
type: LocalParameter
units: 033007
value: 0.0

647025
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: pydam_b

645797
type: Species
notes: FORMULA: I
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Iodide

647477
type: Reaction
kinetic law: 047471
product: 047459
reactant: 047447
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: false
name: NADPH transporter, peroxisome

653157
type: LocalParameter
units: 032971
value: 500.0

653154
type: LocalParameter
value: 0.0

653151
type: LocalParameter
units: 033007
value: 1000.0

653148
type: LocalParameter
units: 033007
value: 0.0

047459
type: SpeciesReference
stoichiometry: 1.0
species: 646022

646022
type: Species
notes: FORMULA: C21H26N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Nicotinamide adenine dinucleotide phosphate - reduced

047447
type: SpeciesReference
stoichiometry: 1.0
species: 646018

650530
type: Reaction
kinetic law: 131661
product: 131649
reactant: 131636
fast: false
reversible: true
name: hyaluronan exchange

661734
type: LocalParameter
units: 032971
value: 0.0

661732
type: LocalParameter
value: 0.0

661731
type: LocalParameter
units: 033007
value: 1000.0

661729
type: LocalParameter
units: 033007
value: -1000.0

131649
type: SpeciesReference
stoichiometry: 1.0
species: 647095

647095
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tyr_DASH_L_b

131636
type: SpeciesReference
stoichiometry: 1.0
species: 645724

645724
type: Species
notes: FORMULA: C28H40N2O22
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hyaluronan

645464
type: Species
notes: FORMULA: C32H39NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hydroxylated ebastine

645374
type: Species
notes: FORMULA: H2S2X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Dihydrolipolprotein

647083
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thyox_DASH_L_b

645809
type: Species
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Isoleucine

646989
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: npthl_b

648499
type: Reaction
kinetic law: 085619
product: 085607
reactant: 085594
fast: false
reversible: true
name: Glycine betaine exchange

657550
type: LocalParameter
units: 032971
value: 0.0

657549
type: LocalParameter
value: 0.0

657548
type: LocalParameter
units: 033007
value: 1000.0

657547
type: LocalParameter
units: 033007
value: -1000.0

085607
type: SpeciesReference
stoichiometry: 1.0
species: 646918

646918
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: h2o_b

085594
type: SpeciesReference
stoichiometry: 1.0
species: 645637

648670
type: Reaction
product: 091852
fast: false
reactant: 091828
kinetic law: 091876
reversible: true
notes: GENE_ASSOCIATION: (5230.1) or (348477.1) or (5232.1) GENE_LIST: 348477.1 5230.1 5232.1 SUBSYSTEM: Glycolysis/Gluconeogenesis
name: phosphoglycerate kinase
reactant: 091840
product: 091864

091852
type: SpeciesReference
stoichiometry: 1.0
species: 644657

091828
type: SpeciesReference
stoichiometry: 1.0
species: 644749

658069
type: LocalParameter
units: 032971
value: 0.0

658068
type: LocalParameter
value: 0.0

658067
type: LocalParameter
units: 033007
value: 1000.0

658066
type: LocalParameter
units: 033007
value: -1000.0

091840
type: SpeciesReference
stoichiometry: 1.0
species: 645088

091864
type: SpeciesReference
stoichiometry: 1.0
species: 644974

650519
type: Reaction
kinetic law: 131394
product: 131382
reactant: 131369
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: hydroxyphenylacetate transport via diffusion

661706
type: LocalParameter
units: 032971
value: 0.0

661705
type: LocalParameter
value: 0.0

661703
type: LocalParameter
units: 033007
value: 1000.0

661702
type: LocalParameter
units: 033007
value: -1000.0

131382
type: SpeciesReference
stoichiometry: 1.0
species: 644776

644776
type: Species
notes: FORMULA: C8H7O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 4-Hydroxyphenylacetate

131369
type: SpeciesReference
stoichiometry: 1.0
species: 644774

645461
type: Species
notes: FORMULA: C32H39NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: ebastine

644852
type: Species
notes: FORMULA: C44H51N12O21
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: hexaglutamyl folate (THF)

649111
type: Reaction
product: 101732
notes: GENE_ASSOCIATION: (954.2) or (954.1) or (953.1) or (956.1) or (955.1) or (957.1) GENE_LIST: 953.1 954.1 954.2 955.1 956.1 957.1 SUBSYSTEM: Nucleotides
fast: false
reactant: 101696
kinetic law: 101757
product: 101744
name: ATP diphosphohydrolase
product: 101720
reactant: 101708
reversible: false

101732
type: SpeciesReference
stoichiometry: 1.0
species: 645713

101696
type: SpeciesReference
stoichiometry: 1.0
species: 644975

658912
type: LocalParameter
units: 032971
value: 500.0

658911
type: LocalParameter
value: 0.0

658909
type: LocalParameter
units: 033007
value: 1000.0

658908
type: LocalParameter
units: 033007
value: 0.0

101744
type: SpeciesReference
stoichiometry: 1.0
species: 646195

101720
type: SpeciesReference
stoichiometry: 1.0
species: 645038

645038
type: Species
notes: FORMULA: C10H12N5O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: AMP

101708
type: SpeciesReference
stoichiometry: 1.0
species: 645701

646867
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: din_b

646268
type: Species
notes: FORMULA: C8H12N2O5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Pyridoxamine 5'-phosphate

645529
type: Species
notes: FORMULA: Fe
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Fe2+

649156
type: Reaction
reactant: 102467
product: 102504
reversible: false
reactant: 102479
name: 3',5'-cyclic-nucleotide phosphodiesterase
product: 102491
notes: GENE_ASSOCIATION: (5137.1) or (5142.1) or (5138.1) or (5151.4) or (5150.2) or (5143.1) or (5150.1) or (5151.5) or (5144.1) or (5151.3) or (5151.1) or (5140.2) or (10846.1) or (5136.2) or (27115.1) or (5141.1) or (8622.1) or (5151.2) or (5136.1) or (5139.1) or (50940.1) or (5153.1) or (5140.1) GENE_LIST: 10846.1 27115.1 50940.1 5136.1 5136.2 5137.1 5138.1 5139.1 5140.1 5140.2 5141.1 5142.1 5143.1 5144.1 5150.1 5150.2 5151.1 5151.2 5151.3 5151.4 5151.5 5153.1 8622.1 SUBSYSTEM: Nucleotides
fast: false
kinetic law: 102516

102467
type: SpeciesReference
stoichiometry: 1.0
species: 645136

645136
type: Species
notes: FORMULA: C10H11N5O6P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: cAMP

102504
type: SpeciesReference
stoichiometry: 1.0
species: 645712

102479
type: SpeciesReference
stoichiometry: 1.0
species: 645700

102491
type: SpeciesReference
stoichiometry: 1.0
species: 645037

658991
type: LocalParameter
units: 032971
value: 500.0

658990
type: LocalParameter
value: 0.0

658989
type: LocalParameter
units: 033007
value: 1000.0

658988
type: LocalParameter
units: 033007
value: 0.0

648856
type: Reaction
name: C-4 sterol methyl oxidase (4,4-dimethylzymosterol)
notes: GENE_ASSOCIATION: (6307.1) GENE_LIST: 6307.1 SUBSYSTEM: Cholesterol Metabolism
product: 096071
product: 096083
reactant: 096023
reactant: 096047
reversible: false
product: 096095
reactant: 096035
reactant: 096059
fast: false
kinetic law: 096107

096071
type: SpeciesReference
stoichiometry: 1.0
species: 644786

096083
type: SpeciesReference
stoichiometry: 4.0
species: 645707

096023
type: SpeciesReference
stoichiometry: 1.0
species: 644761

644761
type: Species
notes: FORMULA: C29H48O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 4,4-dimethylzymosterol

096047
type: SpeciesReference
stoichiometry: 3.0
species: 646021

096095
type: SpeciesReference
stoichiometry: 3.0
species: 646015

096035
type: SpeciesReference
stoichiometry: 3.0
species: 645719

096059
type: SpeciesReference
stoichiometry: 3.0
species: 646063

658423
type: LocalParameter
units: 032971
value: 500.0

658422
type: LocalParameter
value: 0.0

658421
type: LocalParameter
units: 033007
value: 1000.0

658420
type: LocalParameter
units: 033007
value: 0.0

647275
type: Reaction
fast: false
kinetic law: 039475
product: 039439
reactant: 039403
product: 039427
name: Beta oxidation of long chain fatty acid
reactant: 039367
reactant: 039355
product: 039463
reactant: 039379
product: 039415
reversible: false
reactant: 039391
product: 039451
notes: GENE_ASSOCIATION: (35.1) or (35.1) or (34.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation

651827
type: LocalParameter
units: 032971
value: 500.0

651824
type: LocalParameter
value: 0.0

651821
type: LocalParameter
units: 033007
value: 1000.0

651818
type: LocalParameter
units: 033007
value: 0.0

039439
type: SpeciesReference
stoichiometry: 1.0
species: 645716

039403
type: SpeciesReference
stoichiometry: 1.0
species: 646367

039427
type: SpeciesReference
stoichiometry: 1.0
species: 645518

039367
type: SpeciesReference
stoichiometry: 1.0
species: 645512

039355
type: SpeciesReference
stoichiometry: 1.0
species: 645224

039463
type: SpeciesReference
stoichiometry: 1.0
species: 646204

039379
type: SpeciesReference
stoichiometry: 1.0
species: 645704

039415
type: SpeciesReference
stoichiometry: 1.0
species: 644941

039391
type: SpeciesReference
stoichiometry: 1.0
species: 645998

039451
type: SpeciesReference
stoichiometry: 1.0
species: 646006

646303
type: Species
notes: FORMULA: C20H27O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Retinoate

647312
type: Reaction
notes: GENE_ASSOCIATION: (2987.1) GENE_LIST: 2987.1 SUBSYSTEM: Nucleotides
name: guanylate kinase (GMP:ATP)
product: 041007
reactant: 040982
fast: false
kinetic law: 041019
product: 040994
reactant: 040970
reversible: true

041007
type: SpeciesReference
stoichiometry: 1.0
species: 645583

645583
type: Species
notes: FORMULA: C10H12N5O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: GDP

040982
type: SpeciesReference
stoichiometry: 1.0
species: 645656

645656
type: Species
notes: FORMULA: C10H12N5O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: GMP

652063
type: LocalParameter
units: 032971
value: 0.0

652060
type: LocalParameter
value: 0.0

652057
type: LocalParameter
units: 033007
value: 1000.0

652054
type: LocalParameter
units: 033007
value: -1000.0

040994
type: SpeciesReference
stoichiometry: 1.0
species: 644974

040970
type: SpeciesReference
stoichiometry: 1.0
species: 645088

646802
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: adrn_b

647401
type: Reaction
product: 044397
fast: false
kinetic law: 044409
reactant: 044349
reactant: 044361
product: 044385
notes: GENE_ASSOCIATION: (23475.1) GENE_LIST: 23475.1 SUBSYSTEM: NAD Metabolism
reversible: false
name: nicotinate-nucleotide diphosphorylase (carboxylating)
product: 044373
reactant: 044337

044397
type: SpeciesReference
stoichiometry: 1.0
species: 646222

652651
type: LocalParameter
units: 032971
value: 500.0

652648
type: LocalParameter
value: 0.0

652645
type: LocalParameter
units: 033007
value: 1000.0

652642
type: LocalParameter
units: 033007
value: 0.0

044349
type: SpeciesReference
stoichiometry: 1.0
species: 646252

646252
type: Species
notes: FORMULA: C5H8O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5-Phospho-alpha-D-ribose 1-diphosphate

044361
type: SpeciesReference
stoichiometry: 1.0
species: 646289

646289
type: Species
notes: FORMULA: C7H3NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Quinolinate

044385
type: SpeciesReference
stoichiometry: 1.0
species: 646036

044373
type: SpeciesReference
stoichiometry: 1.0
species: 645212

044337
type: SpeciesReference
stoichiometry: 2.0
species: 645712

645193
type: Species
notes: FORMULA: C6H13N3O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Citrulline

646953
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: lac_DASH_L_b

646070
type: Species
notes: FORMULA: O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Superoxide anion

649627
type: Reaction
kinetic law: 112019
product: 112007
reactant: 111995
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) GENE_LIST: 124935.1 8501.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-leucine transport via diffusion (extracellular to cytosol)

659837
type: LocalParameter
units: 032971
value: 0.0

659836
type: LocalParameter
value: 0.0

659834
type: LocalParameter
units: 033007
value: 1000.0

659833
type: LocalParameter
units: 033007
value: -1000.0

112007
type: SpeciesReference
stoichiometry: 1.0
species: 645856

645856
type: Species
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Leucine

111995
type: SpeciesReference
stoichiometry: 1.0
species: 645857

645857
type: Species
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Leucine

647326
type: Reaction
reversible: true
product: 041512
fast: false
kinetic law: 041536
reactant: 041487
reactant: 041499
notes: GENE_ASSOCIATION: (790.1) GENE_LIST: 790.1 SUBSYSTEM: Pyrimidine Biosynthesis
name: dihydroorotase
product: 041524

041512
type: SpeciesReference
stoichiometry: 1.0
species: 645143

645143
type: Species
notes: FORMULA: C5H6N2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Carbamoyl-L-aspartate

652153
type: LocalParameter
units: 032971
value: 0.0

652150
type: LocalParameter
value: 0.0

652147
type: LocalParameter
units: 033007
value: 1000.0

652144
type: LocalParameter
units: 033007
value: -1000.0

041487
type: SpeciesReference
stoichiometry: 1.0
species: 645377

041499
type: SpeciesReference
stoichiometry: 1.0
species: 645700

041524
type: SpeciesReference
stoichiometry: 1.0
species: 645712

646025
type: Species
notes: FORMULA: C6H6N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Nicotinamide

646896
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: gchola_b

647464
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) GENE_LIST: 2180.1 SUBSYSTEM: Fatty acid activation
reactant: 046808
reactant: 046796
fast: false
product: 046832
kinetic law: 046868
product: 046856
product: 046844
name: fatty-acid--CoA ligase
reactant: 046820
reversible: true

046808
type: SpeciesReference
stoichiometry: 1.0
species: 645088

046796
type: SpeciesReference
stoichiometry: 1.0
species: 644986

046832
type: SpeciesReference
stoichiometry: 1.0
species: 644989

644989
type: Species
notes: FORMULA: C43H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: adrenyl coenzyme A

653067
type: LocalParameter
units: 032971
value: 0.0

653064
type: LocalParameter
value: 0.0

653061
type: LocalParameter
units: 033007
value: 1000.0

653058
type: LocalParameter
units: 033007
value: -1000.0

046856
type: SpeciesReference
stoichiometry: 1.0
species: 646222

046844
type: SpeciesReference
stoichiometry: 1.0
species: 645037

046820
type: SpeciesReference
stoichiometry: 1.0
species: 645223

646112
type: Species
notes: FORMULA: C10H10N2O11P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Orotidine 5'-phosphate

650434
type: Reaction
reactant: 128901
kinetic law: 128949
reversible: true
fast: false
product: 128913
product: 128937
reactant: 128889
notes: GENE_ASSOCIATION: (2539.1) GENE_LIST: 2539.1 SUBSYSTEM: Pentose Phosphate Pathway
name: glucose 6-phosphate dehydrogenase
product: 128925

128901
type: SpeciesReference
stoichiometry: 1.0
species: 646010

661470
type: LocalParameter
units: 032971
value: 0.0

661468
type: LocalParameter
value: 0.0

661467
type: LocalParameter
units: 033007
value: 1000.0

661465
type: LocalParameter
units: 033007
value: -1000.0

128913
type: SpeciesReference
stoichiometry: 1.0
species: 644848

128937
type: SpeciesReference
stoichiometry: 1.0
species: 646018

128889
type: SpeciesReference
stoichiometry: 1.0
species: 645563

128925
type: SpeciesReference
stoichiometry: 1.0
species: 645712

645757
type: Species
notes: FORMULA: C18H24O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4,17 dihydroxy estradiol

646983
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: nadp_b

649342
type: Reaction
kinetic law: 106361
product: 106349
reactant: 106337
notes: SUBSYSTEM: Urea cycle/amino group metabolism
fast: false
reversible: false
name: Creatine transport to/from mitochondria via diffusion

659320
type: LocalParameter
units: 032971
value: 500.0

659319
type: LocalParameter
value: 0.0

659317
type: LocalParameter
units: 033007
value: 1000.0

659316
type: LocalParameter
units: 033007
value: 0.0

106349
type: SpeciesReference
stoichiometry: 1.0
species: 645238

645238
type: Species
notes: FORMULA: C4H9N3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Creatine

106337
type: SpeciesReference
stoichiometry: 1.0
species: 645235

645235
type: Species
notes: FORMULA: C4H9N3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Creatine

648577
type: Reaction
kinetic law: 088887
fast: false
reactant: 088851
product: 088863
product: 088875
reactant: 088839
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
reversible: false
name: carnitine transferase

657810
type: LocalParameter
units: 032971
value: 500.0

657809
type: LocalParameter
value: 0.0

657808
type: LocalParameter
units: 033007
value: 1000.0

657807
type: LocalParameter
units: 033007
value: 0.0

088851
type: SpeciesReference
stoichiometry: 1.0
species: 646385

646385
type: Species
notes: FORMULA: C25H41NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: stearidonyl carnitine

088863
type: SpeciesReference
stoichiometry: 1.0
species: 645247

088875
type: SpeciesReference
stoichiometry: 1.0
species: 646381

646381
type: Species
notes: FORMULA: C39H58N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: stearidonyl coenzyme A

088839
type: SpeciesReference
stoichiometry: 1.0
species: 645224

646805
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: aflatoxin_b

650382
type: Reaction
kinetic law: 127494
product: 127482
reactant: 127470
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport

661327
type: LocalParameter
units: 032971
value: 0.0

661325
type: LocalParameter
value: 0.0

661324
type: LocalParameter
units: 033007
value: 1000.0

661322
type: LocalParameter
units: 033007
value: -1000.0

127482
type: SpeciesReference
stoichiometry: 1.0
species: 645055

645055
type: Species
notes: FORMULA: C41H70N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: arachidyl coenzyme A

127470
type: SpeciesReference
stoichiometry: 1.0
species: 645052

645052
type: Species
notes: FORMULA: C41H70N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: arachidyl coenzyme A

647630
type: Reaction
reversible: false
fast: false
reactant: 053320
notes: GENE_ASSOCIATION: (5834.1) or (5837.1) or (5836.1) GENE_LIST: 5834.1 5836.1 5837.1 SUBSYSTEM: Starch and Sucrose Metabolism
kinetic law: 053369
reactant: 053333
name: glycogen phosphorylase (glygn2 -> dxtrn)
product: 053357
product: 053345

053320
type: SpeciesReference
stoichiometry: 1.0
species: 645650

645650
type: Species
notes: FORMULA: C66H111O56X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})

653987
type: LocalParameter
units: 032971
value: 500.0

653985
type: LocalParameter
value: 0.0

653983
type: LocalParameter
units: 033007
value: 1000.0

653981
type: LocalParameter
units: 033007
value: 0.0

053333
type: SpeciesReference
stoichiometry: 3.0
species: 646193

053357
type: SpeciesReference
stoichiometry: 3.0
species: 645559

053345
type: SpeciesReference
stoichiometry: 1.0
species: 645451

650682
type: Reaction
kinetic law: 136406
product: 136394
fast: false
product: 136370
name: nucleoside-triphosphatase (GTP)
product: 136382
notes: GENE_ASSOCIATION: (124583.1) GENE_LIST: 124583.1 SUBSYSTEM: Nucleotides
reactant: 136345
reactant: 136358
reversible: false

662152
type: LocalParameter
units: 032971
value: 500.0

662150
type: LocalParameter
value: 0.0

662149
type: LocalParameter
units: 033007
value: 1000.0

662147
type: LocalParameter
units: 033007
value: 0.0

136394
type: SpeciesReference
stoichiometry: 1.0
species: 646195

136370
type: SpeciesReference
stoichiometry: 1.0
species: 645584

645584
type: Species
notes: FORMULA: C10H12N5O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: GDP

136382
type: SpeciesReference
stoichiometry: 1.0
species: 645713

136345
type: SpeciesReference
stoichiometry: 1.0
species: 645676

645676
type: Species
notes: FORMULA: C10H12N5O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: GTP

136358
type: SpeciesReference
stoichiometry: 1.0
species: 645701

648862
type: Reaction
product: 096203
reactant: 096191
product: 096227
notes: GENE_ASSOCIATION: (5409.1) GENE_LIST: 5409.1 SUBSYSTEM: Tyrosine metabolism
product: 096215
reversible: false
name: noradrenaline N-methyltransferase
kinetic law: 096239
reactant: 096179
fast: false

096203
type: SpeciesReference
stoichiometry: 1.0
species: 644996

644996
type: Species
notes: FORMULA: C9H14NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Adrenaline

096191
type: SpeciesReference
stoichiometry: 1.0
species: 646048

646048
type: Species
notes: FORMULA: C8H12NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Norepinephrine

096227
type: SpeciesReference
stoichiometry: 1.0
species: 645712

096215
type: SpeciesReference
stoichiometry: 1.0
species: 645002

658431
type: LocalParameter
units: 032971
value: 500.0

658430
type: LocalParameter
value: 0.0

658429
type: LocalParameter
units: 033007
value: 1000.0

658428
type: LocalParameter
units: 033007
value: 0.0

096179
type: SpeciesReference
stoichiometry: 1.0
species: 645031

650838
type: Reaction
kinetic law: 141317
product: 141293
fast: false
product: 141305
name: glucose-6-phosphate dehydrogenase, endoplasmic reticulum
product: 141281
reactant: 141256
reactant: 141268
notes: GENE_ASSOCIATION: (9563.1) GENE_LIST: 9563.1 SUBSYSTEM: Pentose Phosphate Pathway
reversible: true

662605
type: LocalParameter
units: 032971
value: 0.0

662603
type: LocalParameter
value: 0.0

662601
type: LocalParameter
units: 033007
value: 1000.0

662600
type: LocalParameter
units: 033007
value: -1000.0

141293
type: SpeciesReference
stoichiometry: 1.0
species: 645719

141305
type: SpeciesReference
stoichiometry: 1.0
species: 646007

646007
type: Species
notes: FORMULA: C21H27N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Nicotinamide adenine dinucleotide - reduced

141281
type: SpeciesReference
stoichiometry: 1.0
species: 644849

644849
type: Species
notes: FORMULA: C6H9O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 6-phospho-D-glucono-1,5-lactone

141256
type: SpeciesReference
stoichiometry: 1.0
species: 645565

141268
type: SpeciesReference
stoichiometry: 1.0
species: 646001

646001
type: Species
notes: FORMULA: C21H26N7O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Nicotinamide adenine dinucleotide

650338
type: Reaction
kinetic law: 126322
product: 126310
reactant: 126298
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: GMP nuclear transport

661206
type: LocalParameter
units: 032971
value: 0.0

661204
type: LocalParameter
value: 0.0

661203
type: LocalParameter
units: 033007
value: 1000.0

661201
type: LocalParameter
units: 033007
value: -1000.0

126310
type: SpeciesReference
stoichiometry: 1.0
species: 645659

645659
type: Species
notes: FORMULA: C10H12N5O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: GMP

126298
type: SpeciesReference
stoichiometry: 1.0
species: 645656

645572
type: Species
notes: FORMULA: C2H4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Glycolaldehyde

646792
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: acald_b

649429
type: Reaction
kinetic law: 108195
product: 108183
reactant: 108170
notes: SUBSYSTEM: R Group Synthesis
fast: false
reversible: false
name: R group artificial flux

659476
type: LocalParameter
units: 032971
value: 500.0

659475
type: LocalParameter
value: 0.0

659473
type: LocalParameter
units: 033007
value: 1000.0

659472
type: LocalParameter
units: 033007
value: 0.0

108183
type: SpeciesReference
stoichiometry: 0.875
species: 644887

108170
type: SpeciesReference
stoichiometry: 1.0
species: 646424

646141
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)

648232
type: Reaction
reactant: 076139
notes: GENE_ASSOCIATION: (32.1) GENE_LIST: 32.1 SUBSYSTEM: Fatty Acid Metabolism
reactant: 076164
product: 076212
product: 076200
fast: false
name: Acetyl-Coa carboxylase, beta isoform
reversible: false
product: 076176
product: 076188
reactant: 076151
kinetic law: 076224

076139
type: SpeciesReference
stoichiometry: 1.0
species: 644941

076164
type: SpeciesReference
stoichiometry: 1.0
species: 645733

645733
type: Species
notes: FORMULA: CHO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Bicarbonate

076212
type: SpeciesReference
stoichiometry: 1.0
species: 646196

076200
type: SpeciesReference
stoichiometry: 1.0
species: 645929

645929
type: Species
notes: FORMULA: C24H33N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Malonyl-CoA

076176
type: SpeciesReference
stoichiometry: 1.0
species: 644977

076188
type: SpeciesReference
stoichiometry: 1.0
species: 645716

076151
type: SpeciesReference
stoichiometry: 1.0
species: 645091

656663
type: LocalParameter
units: 032971
value: 500.0

656661
type: LocalParameter
value: 0.0

656660
type: LocalParameter
units: 033007
value: 1000.0

656659
type: LocalParameter
units: 033007
value: 0.0

647545
type: Reaction
name: L-glutamate 5-semialdehyde dehydratase, reversible, mitochondrial
fast: false
notes: SUBSYSTEM: Arginine and Proline Metabolism
product: 049842
kinetic law: 049866
reactant: 049818
product: 049830
reversible: true
product: 049854

049842
type: SpeciesReference
stoichiometry: 1.0
species: 645704

653559
type: LocalParameter
units: 032971
value: 0.0

653557
type: LocalParameter
value: 0.0

653555
type: LocalParameter
units: 033007
value: 1000.0

653553
type: LocalParameter
units: 033007
value: -1000.0

049818
type: SpeciesReference
stoichiometry: 1.0
species: 645610

645610
type: Species
notes: FORMULA: C5H9NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Glutamate 5-semialdehyde

049830
type: SpeciesReference
stoichiometry: 1.0
species: 644668

049854
type: SpeciesReference
stoichiometry: 1.0
species: 645716

648091
type: Reaction
kinetic law: 072097
product: 072085
reactant: 072073
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: Phosphate transporter, peroxisome

656183
type: LocalParameter
units: 032971
value: 0.0

656181
type: LocalParameter
value: 0.0

656179
type: LocalParameter
units: 033007
value: 1000.0

656177
type: LocalParameter
units: 033007
value: -1000.0

072085
type: SpeciesReference
stoichiometry: 1.0
species: 646201

646201
type: Species
notes: FORMULA: HO4P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Phosphate

072073
type: SpeciesReference
stoichiometry: 1.0
species: 646193

650574
type: Reaction
kinetic law: 133035
name: prostaglandin transport via bicarbonate countertransport
product: 133023
reversible: true
notes: GENE_ASSOCIATION: (6578.1) GENE_LIST: 6578.1 SUBSYSTEM: Transport, Extracellular
reactant: 132999
reactant: 132987
fast: false
product: 133011

661855
type: LocalParameter
units: 032971
value: 0.0

661853
type: LocalParameter
value: 0.0

661852
type: LocalParameter
units: 033007
value: 1000.0

661850
type: LocalParameter
units: 033007
value: -1000.0

133023
type: SpeciesReference
stoichiometry: 1.0
species: 646244

646244
type: Species
notes: FORMULA: C20H31O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Prostaglandin D2

132999
type: SpeciesReference
stoichiometry: 1.0
species: 646246

646246
type: Species
notes: FORMULA: C20H31O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Prostaglandin D2

132987
type: SpeciesReference
stoichiometry: 1.0
species: 645730

133011
type: SpeciesReference
stoichiometry: 1.0
species: 645731

650111
type: Reaction
kinetic law: 121613
product: 121601
reactant: 121589
notes: SUBSYSTEM: Carnitine shuttle
fast: false
reversible: false
name: transport into the mitochondria from cytosol (carnitine)

660771
type: LocalParameter
units: 032971
value: 500.0

660770
type: LocalParameter
value: 0.0

660768
type: LocalParameter
units: 033007
value: 1000.0

660767
type: LocalParameter
units: 033007
value: 0.0

121601
type: SpeciesReference
stoichiometry: 1.0
species: 646162

121589
type: SpeciesReference
stoichiometry: 1.0
species: 646160

646160
type: Species
notes: FORMULA: C10H19NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: propionyl-carnitine

647435
type: Reaction
name: oxalate transport via bicarbonate countertransport
reactant: 045840
kinetic law: 045892
notes: GENE_ASSOCIATION: (1836.1) or (10861.1) or (10861.3) or (10861.2) or (1811.1) GENE_LIST: 10861.1 10861.2 10861.3 1811.1 1836.1 SUBSYSTEM: Transport, Extracellular
product: 045866
reversible: false
product: 045879
reactant: 045853
fast: false

045840
type: SpeciesReference
stoichiometry: 2.0
species: 645730

652881
type: LocalParameter
units: 032971
value: 500.0

652878
type: LocalParameter
value: 0.0

652875
type: LocalParameter
units: 033007
value: 1000.0

652872
type: LocalParameter
units: 033007
value: 0.0

045866
type: SpeciesReference
stoichiometry: 2.0
species: 645731

045879
type: SpeciesReference
stoichiometry: 1.0
species: 646115

045853
type: SpeciesReference
stoichiometry: 1.0
species: 646117

646466
type: Species
notes: FORMULA: C12H17N4OS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Thiamin

649561
type: Reaction
kinetic law: 110946
product: 110934
reactant: 110922
notes: GENE_ASSOCIATION: (11212.1) GENE_LIST: 11212.1 SUBSYSTEM: Alanine and Aspartate Metabolism
fast: false
reversible: true
name: alanine racemase

659718
type: LocalParameter
units: 032971
value: 0.0

659716
type: LocalParameter
value: 0.0

659715
type: LocalParameter
units: 033007
value: 1000.0

659713
type: LocalParameter
units: 033007
value: -1000.0

110934
type: SpeciesReference
stoichiometry: 1.0
species: 645016

110922
type: SpeciesReference
stoichiometry: 1.0
species: 645020

645020
type: Species
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Alanine

648667
type: Reaction
fast: false
kinetic law: 091816
product: 091792
product: 091804
notes: GENE_ASSOCIATION: (23464.1) GENE_LIST: 23464.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
name: glycine C-acetyltransferase
reversible: true
reactant: 091780
reactant: 091768

658063
type: LocalParameter
units: 032971
value: 0.0

658062
type: LocalParameter
value: 0.0

658061
type: LocalParameter
units: 033007
value: 1000.0

658060
type: LocalParameter
units: 033007
value: -1000.0

091792
type: SpeciesReference
stoichiometry: 1.0
species: 644675

644675
type: Species
notes: FORMULA: C4H7NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-2-Amino-3-oxobutanoate

091804
type: SpeciesReference
stoichiometry: 1.0
species: 645224

091780
type: SpeciesReference
stoichiometry: 1.0
species: 645631

645631
type: Species
notes: FORMULA: C2H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Glycine

091768
type: SpeciesReference
stoichiometry: 1.0
species: 644941

647470
type: Reaction
kinetic law: 047156
product: 047144
product: 047132
reactant: 047120
notes: GENE_ASSOCIATION: (549.1) or (3030.1) and (3032.1) or (1892.1) GENE_LIST: 1892.1 3030.1 3032.1 549.1 SUBSYSTEM: Tryptophan metabolism
fast: false
reversible: true
name: 3-hydroxyacyl-CoA dehydratase (3-hydroxybutanoyl-CoA) (mitochondria)

653107
type: LocalParameter
units: 032971
value: 0.0

653104
type: LocalParameter
value: 0.0

653101
type: LocalParameter
units: 033007
value: 1000.0

653098
type: LocalParameter
units: 033007
value: -1000.0

047144
type: SpeciesReference
stoichiometry: 1.0
species: 645704

047132
type: SpeciesReference
stoichiometry: 1.0
species: 645098

645098
type: Species
notes: FORMULA: C25H36N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Crotonoyl-CoA

047120
type: SpeciesReference
stoichiometry: 1.0
species: 644725

646138
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: phosphatidylinositol 4,5-bisphosphate (Homo sapiens)

645686
type: Species
notes: FORMULA: C6H11O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Gulonate

645005
type: Species
notes: FORMULA: C14H20N6O5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: S-Adenosyl-L-homocysteine

645751
type: Species
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: trans-Hexadec-2-enoyl-CoA

647040
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ser_DASH_L_b

647656
type: Reaction
kinetic law: 054489
product: 054477
reactant: 054465
notes: GENE_ASSOCIATION: (8501.1) or (124935.1) GENE_LIST: 124935.1 8501.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: L-valine transport via diffusion (extracellular to cytosol)

654106
type: LocalParameter
units: 032971
value: 0.0

654104
type: LocalParameter
value: 0.0

654102
type: LocalParameter
units: 033007
value: 1000.0

654100
type: LocalParameter
units: 033007
value: -1000.0

054477
type: SpeciesReference
stoichiometry: 1.0
species: 646588

646588
type: Species
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Valine

054465
type: SpeciesReference
stoichiometry: 1.0
species: 646589

646589
type: Species
notes: FORMULA: C5H11NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Valine

649402
type: Reaction
kinetic law: 107521
product: 107509
reactant: 107497
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: prist peroxisomal transport

659427
type: LocalParameter
units: 032971
value: 0.0

659426
type: LocalParameter
value: 0.0

659425
type: LocalParameter
units: 033007
value: 1000.0

659424
type: LocalParameter
units: 033007
value: -1000.0

107509
type: SpeciesReference
stoichiometry: 1.0
species: 646234

646234
type: Species
notes: FORMULA: C19H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: pristanic acid

107497
type: SpeciesReference
stoichiometry: 1.0
species: 646235

646235
type: Species
notes: FORMULA: C19H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: pristanic acid

649912
type: Reaction
fast: false
name: Malonyl-CoA Decarboxylase cytoplasmic
reversible: false
product: 117566
reactant: 117542
product: 117578
notes: GENE_ASSOCIATION: (23417.1) GENE_LIST: 23417.1 SUBSYSTEM: Fatty Acid Metabolism
kinetic law: 117590
reactant: 117554

117566
type: SpeciesReference
stoichiometry: 1.0
species: 644939

117542
type: SpeciesReference
stoichiometry: 1.0
species: 645712

117578
type: SpeciesReference
stoichiometry: 1.0
species: 645212

660356
type: LocalParameter
units: 032971
value: 500.0

660354
type: LocalParameter
value: 0.0

660353
type: LocalParameter
units: 033007
value: 1000.0

660351
type: LocalParameter
units: 033007
value: 0.0

117554
type: SpeciesReference
stoichiometry: 1.0
species: 645928

647356
type: Reaction
notes: GENE_ASSOCIATION: (9563.1) GENE_LIST: 9563.1 SUBSYSTEM: Pentose Phosphate Pathway
reactant: 042686
kinetic law: 042734
product: 042722
reversible: true
reactant: 042674
product: 042698
product: 042710
name: glucose 6-phosphate dehydrogenase, endoplasmic reticulum
fast: false

042686
type: SpeciesReference
stoichiometry: 1.0
species: 646015

652353
type: LocalParameter
units: 032971
value: 0.0

652350
type: LocalParameter
value: 0.0

652347
type: LocalParameter
units: 033007
value: 1000.0

652344
type: LocalParameter
units: 033007
value: -1000.0

042722
type: SpeciesReference
stoichiometry: 1.0
species: 646021

042674
type: SpeciesReference
stoichiometry: 1.0
species: 645565

042698
type: SpeciesReference
stoichiometry: 1.0
species: 644849

042710
type: SpeciesReference
stoichiometry: 1.0
species: 645719

649447
type: Reaction
notes: GENE_ASSOCIATION: (159.1) or (122622.1) or (122622.2) GENE_LIST: 122622.1 122622.2 159.1 SUBSYSTEM: Nucleotides
kinetic law: 108568
product: 108520
reactant: 108495
name: adenylosuccinate synthase
reactant: 108508
fast: false
product: 108544
reversible: false
product: 108532
reactant: 108483
product: 108556

659514
type: LocalParameter
units: 032971
value: 500.0

659513
type: LocalParameter
value: 0.0

659512
type: LocalParameter
units: 033007
value: 1000.0

659511
type: LocalParameter
units: 033007
value: 0.0

108520
type: SpeciesReference
stoichiometry: 1.0
species: 645293

645293
type: Species
notes: FORMULA: C14H14N5O11P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N6-(1,2-Dicarboxyethyl)-AMP

108495
type: SpeciesReference
stoichiometry: 1.0
species: 645674

108508
type: SpeciesReference
stoichiometry: 1.0
species: 645814

108544
type: SpeciesReference
stoichiometry: 2.0
species: 645712

108532
type: SpeciesReference
stoichiometry: 1.0
species: 645583

108483
type: SpeciesReference
stoichiometry: 1.0
species: 645083

645083
type: Species
notes: FORMULA: C4H6NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Aspartate

108556
type: SpeciesReference
stoichiometry: 1.0
species: 646193

649201
type: Reaction
kinetic law: 103395
product: 103383
reactant: 103371
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport

659069
type: LocalParameter
units: 032971
value: 0.0

659067
type: LocalParameter
value: 0.0

659066
type: LocalParameter
units: 033007
value: 1000.0

659064
type: LocalParameter
units: 033007
value: -1000.0

103383
type: SpeciesReference
stoichiometry: 1.0
species: 645140

103371
type: SpeciesReference
stoichiometry: 1.0
species: 645142

645142
type: Species
notes: FORMULA: C10H16O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: (E)-carveol

646256
type: Species
notes: FORMULA: C3H6NO6P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: O-Phospho-L-serine

646166
type: Species
notes: FORMULA: C8H10NO6P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Pyridoxine 5'-phosphate

646766
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 4hphac_b

648706
type: Reaction
kinetic law: 092781
product: 092769
reactant: 092757
fast: false
reversible: true
name: Fe2+ exchange

658139
type: LocalParameter
units: 032971
value: 0.0

658138
type: LocalParameter
value: 0.0

658136
type: LocalParameter
units: 033007
value: 1000.0

658135
type: LocalParameter
units: 033007
value: -1000.0

092769
type: SpeciesReference
stoichiometry: 1.0
species: 646939

646939
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: imp_b

092757
type: SpeciesReference
stoichiometry: 1.0
species: 645530

645530
type: Species
notes: FORMULA: Fe
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Fe2+

646911
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: gsn_b

648221
type: Reaction
reactant: 075835
reversible: false
name: phosphatidylinositol 3-kinase
product: 075871
product: 075847
kinetic law: 075883
fast: false
notes: GENE_ASSOCIATION: (5295.2 and 5291.1) or (23533.1 and 5294.1) or (5290.1 and 5295.1) or (5293.1 and 5295.3) or (5287.1) or (5286.1) or (5293.1 and 5296.1) or (5295.2 and 5293.1) or (5296.1 and 5291.1) or (5290.1 and 5295.3) or (5288.1) or (5290.1 and 8503.1) or (5291.1 and 5295.3) or (10870.1 and 5294.1) or (8503.1 and 5291.1) or (5293.1 and 5295.1) or (5296.1 and 5290.1) or (5289.1) or (5293.1 and 8503.1) or (5291.1 and 5295.1) or (5295.2 and 5290.1) GENE_LIST: 10870.1 23533.1 5286.1 5287.1 5288.1 5289.1 5290.1 5291.1 5293.1 5294.1 5295.1 5295.2 5295.3 5296.1 8503.1 SUBSYSTEM: Inositol Phosphate Metabolism
product: 075859
reactant: 075823

075835
type: SpeciesReference
stoichiometry: 1.0
species: 646144

075871
type: SpeciesReference
stoichiometry: 1.0
species: 646136

075847
type: SpeciesReference
stoichiometry: 1.0
species: 644974

656623
type: LocalParameter
units: 032971
value: 500.0

656621
type: LocalParameter
value: 0.0

656619
type: LocalParameter
units: 033007
value: 1000.0

656617
type: LocalParameter
units: 033007
value: 0.0

075859
type: SpeciesReference
stoichiometry: 1.0
species: 645712

075823
type: SpeciesReference
stoichiometry: 1.0
species: 645088

646253
type: Species
notes: FORMULA: C6H11NO6PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: phosphatidylserine (homo sapiens)

649804
type: Reaction
kinetic law: 115459
product: 115447
reactant: 115435
fast: false
reversible: true
name: Bicarbonate exchange

660158
type: LocalParameter
units: 032971
value: 0.0

660157
type: LocalParameter
value: 0.0

660155
type: LocalParameter
units: 033007
value: 1000.0

660154
type: LocalParameter
units: 033007
value: -1000.0

115447
type: SpeciesReference
stoichiometry: 1.0
species: 647023

647023
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ptdca_b

115435
type: SpeciesReference
stoichiometry: 1.0
species: 645731

648574
type: Reaction
kinetic law: 088743
product: 088731
reactant: 088719
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion

657800
type: LocalParameter
units: 032971
value: 0.0

657799
type: LocalParameter
value: 0.0

657797
type: LocalParameter
units: 033007
value: 1000.0

657796
type: LocalParameter
units: 033007
value: -1000.0

088731
type: SpeciesReference
stoichiometry: 1.0
species: 645304

645304
type: Species
notes: FORMULA: C22H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: docosa-4,7,10,13,16-pentaenoic acid (n-6)

088719
type: SpeciesReference
stoichiometry: 1.0
species: 645305

645305
type: Species
notes: FORMULA: C22H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: docosa-4,7,10,13,16-pentaenoic acid (n-6)

647726
type: Reaction
kinetic law: 057424
product: 057412
reactant: 057400
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: false
name: retinoyl glucuronide efflux (13-cis)

654435
type: LocalParameter
units: 032971
value: 500.0

654433
type: LocalParameter
value: 0.0

654431
type: LocalParameter
units: 033007
value: 1000.0

654429
type: LocalParameter
units: 033007
value: 0.0

057412
type: SpeciesReference
stoichiometry: 1.0
species: 644653

057400
type: SpeciesReference
stoichiometry: 1.0
species: 644651

644651
type: Species
notes: FORMULA: C26H35O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 13-cis-retinoyl glucuronide

650279
type: Reaction
kinetic law: 124758
product: 124746
reactant: 124734
fast: false
reversible: true
name: Pyruvate exchange

661079
type: LocalParameter
units: 032971
value: 0.0

661078
type: LocalParameter
value: 0.0

661076
type: LocalParameter
units: 033007
value: 1000.0

661075
type: LocalParameter
units: 033007
value: -1000.0

124746
type: SpeciesReference
stoichiometry: 1.0
species: 647065

647065
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tcynt_b

124734
type: SpeciesReference
stoichiometry: 1.0
species: 646282

646282
type: Species
notes: FORMULA: C3H3O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Pyruvate

646990
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: nrpphrsf_b

648625
type: Reaction
kinetic law: 090701
product: 090689
reactant: 090677
fast: false
reversible: true
name: L-sulfolactate exchange

657960
type: LocalParameter
units: 032971
value: 0.0

657959
type: LocalParameter
value: 0.0

657958
type: LocalParameter
units: 033007
value: 1000.0

657957
type: LocalParameter
units: 033007
value: -1000.0

090689
type: SpeciesReference
stoichiometry: 1.0
species: 646932

646932
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: hpdca_b

090677
type: SpeciesReference
stoichiometry: 1.0
species: 646334

646334
type: Species
notes: FORMULA: C3H4O6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-sulfolactate

648113
type: Reaction
reversible: false
reactant: 072823
product: 072871
kinetic law: 072883
reactant: 072811
product: 072847
name: dopamine beta-monooxygenase
fast: false
product: 072859
reactant: 072835
notes: GENE_ASSOCIATION: (26002.1) or (1621.1) GENE_LIST: 1621.1 26002.1 SUBSYSTEM: Tyrosine metabolism

072823
type: SpeciesReference
stoichiometry: 1.0
species: 645409

645409
type: Species
notes: FORMULA: C8H12NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Dopamine

072871
type: SpeciesReference
stoichiometry: 1.0
species: 646048

656281
type: LocalParameter
units: 032971
value: 500.0

656279
type: LocalParameter
value: 0.0

656277
type: LocalParameter
units: 033007
value: 1000.0

656275
type: LocalParameter
units: 033007
value: 0.0

072811
type: SpeciesReference
stoichiometry: 1.0
species: 645076

645076
type: Species
notes: FORMULA: C6H8O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Ascorbate

072847
type: SpeciesReference
stoichiometry: 1.0
species: 645361

645361
type: Species
notes: FORMULA: C6H6O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Dehydroascorbate

072859
type: SpeciesReference
stoichiometry: 1.0
species: 645700

072835
type: SpeciesReference
stoichiometry: 1.0
species: 646060

649189
type: Reaction
kinetic law: 103202
product: 103190
reactant: 103178
fast: false
reversible: true
name: L-Threonine exchange

659048
type: LocalParameter
units: 032971
value: 0.0

659047
type: LocalParameter
value: 0.0

659046
type: LocalParameter
units: 033007
value: 1000.0

659045
type: LocalParameter
units: 033007
value: -1000.0

103190
type: SpeciesReference
stoichiometry: 1.0
species: 646980

646980
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: nac_b

103178
type: SpeciesReference
stoichiometry: 1.0
species: 646481

645475
type: Species
notes: FORMULA: C27H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Eicosatetranoyl carnitine

650443
type: Reaction
product: 129167
notes: GENE_ASSOCIATION: (6718.1) GENE_LIST: 6718.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 129155
reactant: 129142
kinetic law: 129191
reactant: 129129
product: 129179
name: aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)
reversible: false
fast: false

129167
type: SpeciesReference
stoichiometry: 1.0
species: 646010

129155
type: SpeciesReference
stoichiometry: 1.0
species: 646624

646624
type: Species
notes: FORMULA: C27H44O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 7alpha,12alpha-Dihydroxycholest-4-en-3-one

129142
type: SpeciesReference
stoichiometry: 1.0
species: 646018

661497
type: LocalParameter
units: 032971
value: 500.0

661496
type: LocalParameter
value: 0.0

661494
type: LocalParameter
units: 033007
value: 1000.0

661493
type: LocalParameter
units: 033007
value: 0.0

129129
type: SpeciesReference
stoichiometry: 1.0
species: 645712

129179
type: SpeciesReference
stoichiometry: 1.0
species: 646627

647135
type: Reaction
reactant: 033633
product: 033657
kinetic law: 033669
reactant: 033609
fast: false
reactant: 033621
notes: GENE_ASSOCIATION: (1717.1) GENE_LIST: 1717.1 SUBSYSTEM: Cholesterol Metabolism
reversible: false
name: 7-dehydrocholesterol reductase
product: 033645

033633
type: SpeciesReference
stoichiometry: 1.0
species: 646021

033657
type: SpeciesReference
stoichiometry: 1.0
species: 646015

650971
type: LocalParameter
units: 032971
value: 500.0

650968
type: LocalParameter
value: 0.0

650967
type: LocalParameter
units: 033007
value: 1000.0

650964
type: LocalParameter
units: 033007
value: 0.0

033609
type: SpeciesReference
stoichiometry: 1.0
species: 645325

033621
type: SpeciesReference
stoichiometry: 1.0
species: 645719

033645
type: SpeciesReference
stoichiometry: 1.0
species: 645419

647645
type: Reaction
product: 053998
reactant: 053914
product: 054010
notes: GENE_ASSOCIATION: (35.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation
product: 053974
reactant: 053950
product: 054022
product: 053986
reversible: false
reactant: 053926
reactant: 053938
fast: false
reactant: 053962
name: Beta oxidation of long chain fatty acid
kinetic law: 054035

053998
type: SpeciesReference
stoichiometry: 1.0
species: 645716

053914
type: SpeciesReference
stoichiometry: 1.0
species: 645224

054010
type: SpeciesReference
stoichiometry: 1.0
species: 646006

053974
type: SpeciesReference
stoichiometry: 1.0
species: 644941

053950
type: SpeciesReference
stoichiometry: 1.0
species: 645998

054022
type: SpeciesReference
stoichiometry: 1.0
species: 646496

646496
type: Species
notes: FORMULA: C41H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: timnodonyl coenzyme A

053986
type: SpeciesReference
stoichiometry: 1.0
species: 645697

053926
type: SpeciesReference
stoichiometry: 1.0
species: 645308

645308
type: Species
notes: FORMULA: C43H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A

053938
type: SpeciesReference
stoichiometry: 1.0
species: 645704

053962
type: SpeciesReference
stoichiometry: 1.0
species: 646061

654057
type: LocalParameter
units: 032971
value: 500.0

654055
type: LocalParameter
value: 0.0

654053
type: LocalParameter
units: 033007
value: 1000.0

654051
type: LocalParameter
units: 033007
value: 0.0

646012
type: Species
notes: FORMULA: C21H25N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Nicotinamide adenine dinucleotide phosphate

649684
type: Reaction
kinetic law: 113192
product: 113180
reactant: 113168
fast: false
reversible: true
name: L-Lysine exchange

659939
type: LocalParameter
units: 032971
value: 0.0

659938
type: LocalParameter
value: 0.0

659936
type: LocalParameter
units: 033007
value: 1000.0

659935
type: LocalParameter
units: 033007
value: -1000.0

113180
type: SpeciesReference
stoichiometry: 1.0
species: 647013

647013
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: phe_DASH_L_b

113168
type: SpeciesReference
stoichiometry: 1.0
species: 645917

645149
type: Species
notes: FORMULA: C9H12N3O11P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: CDP

647515
type: Reaction
reactant: 048803
product: 048827
fast: false
kinetic law: 048839
name: nucleotide phosphatase
notes: GENE_ASSOCIATION: (4860.1) GENE_LIST: 4860.1 SUBSYSTEM: NAD Metabolism
reactant: 048779
reversible: false
reactant: 048791
product: 048815

048803
type: SpeciesReference
stoichiometry: 1.0
species: 646291

048827
type: SpeciesReference
stoichiometry: 1.0
species: 646193

653396
type: LocalParameter
units: 032971
value: 500.0

653393
type: LocalParameter
value: 0.0

653391
type: LocalParameter
units: 033007
value: 1000.0

653389
type: LocalParameter
units: 033007
value: 0.0

048779
type: SpeciesReference
stoichiometry: 1.0
species: 645712

048791
type: SpeciesReference
stoichiometry: 1.0
species: 645992

645992
type: Species
notes: FORMULA: C6H4NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Nicotinate

048815
type: SpeciesReference
stoichiometry: 1.0
species: 646034

645046
type: Species
notes: FORMULA: C11H12N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: antipyrene

646369
type: Species
notes: FORMULA: C39H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Stearoyl-CoA (n-C18:0CoA)

650261
type: Reaction
fast: false
product: 124352
kinetic law: 124388
reversible: false
reactant: 124328
product: 124376
name: hydroxyacylglutathione hydrolase
notes: GENE_ASSOCIATION: (3029.1) or (84264.2) or (84264.1) GENE_LIST: 3029.1 84264.1 84264.2 SUBSYSTEM: Pyruvate Metabolism
product: 124364
reactant: 124340

124352
type: SpeciesReference
stoichiometry: 1.0
species: 645670

661046
type: LocalParameter
units: 032971
value: 500.0

661045
type: LocalParameter
value: 0.0

661043
type: LocalParameter
units: 033007
value: 1000.0

661042
type: LocalParameter
units: 033007
value: 0.0

124328
type: SpeciesReference
stoichiometry: 1.0
species: 645700

124376
type: SpeciesReference
stoichiometry: 1.0
species: 645842

645842
type: Species
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Lactate

124364
type: SpeciesReference
stoichiometry: 1.0
species: 645712

124340
type: SpeciesReference
stoichiometry: 1.0
species: 645866

649810
type: Reaction
kinetic law: 115567
product: 115555
reactant: 115543
fast: false
reversible: true
name: hexadecenoate (n-C16:1) exchange

660169
type: LocalParameter
units: 032971
value: 0.0

660168
type: LocalParameter
value: 0.0

660166
type: LocalParameter
units: 033007
value: 1000.0

660165
type: LocalParameter
units: 033007
value: -1000.0

115555
type: SpeciesReference
stoichiometry: 1.0
species: 647025

115543
type: SpeciesReference
stoichiometry: 1.0
species: 645742

646279
type: Species
notes: FORMULA: C8H11NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Pyridoxine

645236
type: Species
notes: FORMULA: C4H9N3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Creatine

645146
type: Species
notes: FORMULA: CH2NO5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Carbamoyl phosphate

645043
type: Species
notes: FORMULA: C6H6NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2-Aminomuconate

650806
type: Reaction
kinetic law: 140337
product: 140325
reactant: 140313
reactant: 140301
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
fast: false
reversible: true
name: UMP kinase (UTP)

662509
type: LocalParameter
units: 032971
value: 0.0

662507
type: LocalParameter
value: 0.0

662505
type: LocalParameter
units: 033007
value: 1000.0

662504
type: LocalParameter
units: 033007
value: -1000.0

140325
type: SpeciesReference
stoichiometry: 2.0
species: 646535

140313
type: SpeciesReference
stoichiometry: 1.0
species: 646574

140301
type: SpeciesReference
stoichiometry: 1.0
species: 646549

648631
type: Reaction
kinetic law: 090845
product: 090833
reactant: 090821
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: sphingosine-1-phosphate transport

657976
type: LocalParameter
units: 032971
value: 0.0

657975
type: LocalParameter
value: 0.0

657974
type: LocalParameter
units: 033007
value: 1000.0

657973
type: LocalParameter
units: 033007
value: -1000.0

090833
type: SpeciesReference
stoichiometry: 1.0
species: 646355

646355
type: Species
notes: FORMULA: C18H37NO5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Sphingosine 1-phosphate

090821
type: SpeciesReference
stoichiometry: 1.0
species: 646354

646081
type: Species
notes: FORMULA: C18H35O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: octadecanoate (n-C18:0)

646861
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: dgchol_b

646262
type: Species
notes: FORMULA: C36H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: pentadecanoyl Coenzyme A

649195
type: Reaction
reversible: true
reactant: 103275
notes: GENE_ASSOCIATION: (83884.1) or (10166.1) GENE_LIST: 10166.1 83884.1 SUBSYSTEM: Transport, Mitochondrial
name: arginine mitochondrial transport via ornithine carrier
fast: false
kinetic law: 103323
reactant: 103287
product: 103311
product: 103299

103275
type: SpeciesReference
stoichiometry: 1.0
species: 645070

659059
type: LocalParameter
units: 032971
value: 0.0

659058
type: LocalParameter
value: 0.0

659057
type: LocalParameter
units: 033007
value: 1000.0

659056
type: LocalParameter
units: 033007
value: -1000.0

103287
type: SpeciesReference
stoichiometry: 1.0
species: 645716

103311
type: SpeciesReference
stoichiometry: 1.0
species: 645712

103299
type: SpeciesReference
stoichiometry: 1.0
species: 645073

645073
type: Species
notes: FORMULA: C6H15N4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Arginine

648044
type: Reaction
notes: GENE_ASSOCIATION: (6785.1) GENE_LIST: 6785.1 SUBSYSTEM: Fatty acid elongation
reversible: false
reactant: 070052
reactant: 070040
product: 070088
reactant: 070027
product: 070064
product: 070112
product: 070100
fast: false
reactant: 070003
kinetic law: 070124
name: fatty-acyl-CoA elongation (n-C20:4CoA)
reactant: 070015
product: 070076

070052
type: SpeciesReference
stoichiometry: 1.0
species: 646060

070040
type: SpeciesReference
stoichiometry: 4.0
species: 646018

070088
type: SpeciesReference
stoichiometry: 1.0
species: 645223

070027
type: SpeciesReference
stoichiometry: 1.0
species: 645928

070064
type: SpeciesReference
stoichiometry: 1.0
species: 644989

070112
type: SpeciesReference
stoichiometry: 4.0
species: 646010

070100
type: SpeciesReference
stoichiometry: 3.0
species: 645700

070003
type: SpeciesReference
stoichiometry: 1.0
species: 645062

645062
type: Species
notes: FORMULA: C41H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: C20:4-CoA

655966
type: LocalParameter
units: 032971
value: 500.0

655964
type: LocalParameter
value: 0.0

655962
type: LocalParameter
units: 033007
value: 1000.0

655960
type: LocalParameter
units: 033007
value: 0.0

070015
type: SpeciesReference
stoichiometry: 5.0
species: 645712

070076
type: SpeciesReference
stoichiometry: 1.0
species: 645212

649117
type: Reaction
fast: false
reversible: true
product: 101841
product: 101829
reactant: 101805
reactant: 101817
kinetic law: 101865
notes: GENE_ASSOCIATION: (275.1) and (1738.1) and (2731.1) and (2653.1) GENE_LIST: 1738.1 2653.1 2731.1 275.1 SUBSYSTEM: Glycine, Serine, and Threonine Metabolism
product: 101853
name: glycine-cleavage complex (lipoylprotein), mitochondrial

101841
type: SpeciesReference
stoichiometry: 1.0
species: 645913

101829
type: SpeciesReference
stoichiometry: 1.0
species: 645716

101805
type: SpeciesReference
stoichiometry: 1.0
species: 645374

101817
type: SpeciesReference
stoichiometry: 1.0
species: 645998

658922
type: LocalParameter
units: 032971
value: 0.0

658921
type: LocalParameter
value: 0.0

658920
type: LocalParameter
units: 033007
value: 1000.0

658919
type: LocalParameter
units: 033007
value: -1000.0

101853
type: SpeciesReference
stoichiometry: 1.0
species: 646006

647239
type: Reaction
kinetic law: 037930
product: 037918
product: 037906
reactant: 037894
notes: SUBSYSTEM: Pyruvate Metabolism
fast: false
reversible: false
name: methyglyoxylate synthase 2 (from g3p)

651605
type: LocalParameter
units: 032971
value: 500.0

651602
type: LocalParameter
value: 0.0

651599
type: LocalParameter
units: 033007
value: 1000.0

651598
type: LocalParameter
units: 033007
value: 0.0

037918
type: SpeciesReference
stoichiometry: 1.0
species: 646193

037906
type: SpeciesReference
stoichiometry: 1.0
species: 645985

037894
type: SpeciesReference
stoichiometry: 1.0
species: 645560

648133
type: Reaction
kinetic law: 073305
product: 073293
reactant: 073281
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: coenzyme A transport, nuclear

656344
type: LocalParameter
units: 032971
value: 0.0

656342
type: LocalParameter
value: 0.0

656340
type: LocalParameter
units: 033007
value: 1000.0

656338
type: LocalParameter
units: 033007
value: -1000.0

073293
type: SpeciesReference
stoichiometry: 1.0
species: 645226

645226
type: Species
notes: FORMULA: C21H32N7O16P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: Coenzyme A

073281
type: SpeciesReference
stoichiometry: 1.0
species: 645223

647314
type: Reaction
kinetic law: 041055
product: 041043
reactant: 041031
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport

652073
type: LocalParameter
units: 032971
value: 0.0

652070
type: LocalParameter
value: 0.0

652067
type: LocalParameter
units: 033007
value: 1000.0

652064
type: LocalParameter
units: 033007
value: -1000.0

041043
type: SpeciesReference
stoichiometry: 1.0
species: 646432

646432
type: Species
notes: FORMULA: C45H66N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: tetracosahexaenoyl coenzyme A

041031
type: SpeciesReference
stoichiometry: 1.0
species: 646430

650343
type: Reaction
kinetic law: 126457
product: 126445
reactant: 126433
fast: false
reversible: true
name: Taurine exchange

661222
type: LocalParameter
units: 032971
value: 0.0

661221
type: LocalParameter
value: 0.0

661219
type: LocalParameter
units: 033007
value: 1000.0

661218
type: LocalParameter
units: 033007
value: -1000.0

126445
type: SpeciesReference
stoichiometry: 1.0
species: 647071

647071
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetpent6_b

126433
type: SpeciesReference
stoichiometry: 1.0
species: 646405

646405
type: Species
notes: FORMULA: C2H7NO3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Taurine

650897
type: Reaction
kinetic law: 142861
product: 142849
reactant: 142837
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: false
name: FAD transporter, endoplasmic reticulum

662755
type: LocalParameter
units: 032971
value: 500.0

662753
type: LocalParameter
value: 0.0

662751
type: LocalParameter
units: 033007
value: 1000.0

662750
type: LocalParameter
units: 033007
value: 0.0

142849
type: SpeciesReference
stoichiometry: 1.0
species: 645511

142837
type: SpeciesReference
stoichiometry: 1.0
species: 645514

645859
type: Species
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Leucine

646417
type: Species
notes: FORMULA: CNS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Thiocyanate

648515
type: Reaction
product: 086252
fast: false
product: 086264
notes: GENE_ASSOCIATION: (22978.1) or (93034.2) or (93034.1) GENE_LIST: 22978.1 93034.1 93034.2 SUBSYSTEM: Nucleotides
reactant: 086240
kinetic law: 086277
reactant: 086228
name: 5'-nucleotidase (AMP)
reversible: false

086252
type: SpeciesReference
stoichiometry: 1.0
species: 644969

644969
type: Species
notes: FORMULA: C10H13N5O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Adenosine

086264
type: SpeciesReference
stoichiometry: 1.0
species: 646193

086240
type: SpeciesReference
stoichiometry: 1.0
species: 645700

657592
type: LocalParameter
units: 032971
value: 500.0

657591
type: LocalParameter
value: 0.0

657590
type: LocalParameter
units: 033007
value: 1000.0

657589
type: LocalParameter
units: 033007
value: 0.0

086228
type: SpeciesReference
stoichiometry: 1.0
species: 645037

647582
type: Reaction
fast: false
reversible: false
reactant: 051448
name: Lathosterol oxidase
product: 051472
product: 051484
reactant: 051424
reactant: 051436
reactant: 051460
kinetic law: 051508
product: 051496
notes: GENE_ASSOCIATION: (6309.1) GENE_LIST: 6309.1 SUBSYSTEM: Cholesterol Metabolism

051448
type: SpeciesReference
stoichiometry: 1.0
species: 646021

051472
type: SpeciesReference
stoichiometry: 1.0
species: 644857

644857
type: Species
notes: FORMULA: C27H44O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 7-Dehydrocholesterol

051484
type: SpeciesReference
stoichiometry: 2.0
species: 645707

051424
type: SpeciesReference
stoichiometry: 1.0
species: 645719

051436
type: SpeciesReference
stoichiometry: 1.0
species: 645914

645914
type: Species
notes: FORMULA: C27H46O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 5alpha-Cholest-7-en-3beta-ol

051460
type: SpeciesReference
stoichiometry: 1.0
species: 646063

653763
type: LocalParameter
units: 032971
value: 500.0

653761
type: LocalParameter
value: 0.0

653758
type: LocalParameter
units: 033007
value: 1000.0

653756
type: LocalParameter
units: 033007
value: 0.0

051496
type: SpeciesReference
stoichiometry: 1.0
species: 646015

647671
type: Reaction
kinetic law: 055142
product: 055129
reactant: 055117
fast: false
reversible: true
name: 3-Methylimidazoleacetic acid exchange

654176
type: LocalParameter
units: 032971
value: 0.0

654174
type: LocalParameter
value: 0.0

654172
type: LocalParameter
units: 033007
value: 1000.0

654170
type: LocalParameter
units: 033007
value: -1000.0

055129
type: SpeciesReference
stoichiometry: 1.0
species: 646828

646828
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: biocyt_b

055117
type: SpeciesReference
stoichiometry: 1.0
species: 644738

644738
type: Species
notes: FORMULA: C6H7N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 3-Methylimidazoleacetic acid

650407
type: Reaction
reversible: false
name: testicular 17-beta-hydroxysteroid dehydrogenase
kinetic law: 128183
reactant: 128123
product: 128159
fast: false
reactant: 128147
notes: GENE_ASSOCIATION: (51478.1) GENE_LIST: 51478.1 SUBSYSTEM: Steroid Metabolism
product: 128171
reactant: 128135

661398
type: LocalParameter
units: 032971
value: 500.0

661397
type: LocalParameter
value: 0.0

661395
type: LocalParameter
units: 033007
value: 1000.0

661394
type: LocalParameter
units: 033007
value: 0.0

128123
type: SpeciesReference
stoichiometry: 1.0
species: 645487

645487
type: Species
notes: FORMULA: C18H22O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Estrone

128159
type: SpeciesReference
stoichiometry: 1.0
species: 645484

128147
type: SpeciesReference
stoichiometry: 1.0
species: 646021

128171
type: SpeciesReference
stoichiometry: 1.0
species: 646015

128135
type: SpeciesReference
stoichiometry: 1.0
species: 645719

646210
type: Species
notes: FORMULA: C9H16NO5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: (R)-Pantothenate

648916
type: Reaction
product: 097800
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
name: folylpolyglutamate synthetase (10fthf)
reversible: false
product: 097764
product: 097776
fast: false
reactant: 097752
kinetic law: 097812
reactant: 097740
reactant: 097728
product: 097788

097800
type: SpeciesReference
stoichiometry: 1.0
species: 646193

097764
type: SpeciesReference
stoichiometry: 1.0
species: 644632

644632
type: Species
notes: FORMULA: C45H51N12O22
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 10-formyltetrahydrofolate-[Glu](6)

097776
type: SpeciesReference
stoichiometry: 1.0
species: 644974

097752
type: SpeciesReference
stoichiometry: 1.0
species: 645611

658584
type: LocalParameter
units: 032971
value: 500.0

658583
type: LocalParameter
value: 0.0

658582
type: LocalParameter
units: 033007
value: 1000.0

658581
type: LocalParameter
units: 033007
value: 0.0

097740
type: SpeciesReference
stoichiometry: 1.0
species: 645088

097728
type: SpeciesReference
stoichiometry: 1.0
species: 644627

644627
type: Species
notes: FORMULA: C40H45N11O19
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 10-formyltetrahydrofolate-[Glu](5)

097788
type: SpeciesReference
stoichiometry: 1.0
species: 645712

647425
type: Reaction
reactant: 045365
product: 045377
reactant: 045341
reversible: false
fast: false
notes: GENE_ASSOCIATION: (1593.1) GENE_LIST: 1593.1 SUBSYSTEM: Bile Acid Biosynthesis
reactant: 045353
product: 045389
name: 5-beta-cytochrome P450, family 27, subfamily A, polypeptide 1
product: 045401
reactant: 045329
kinetic law: 045413

045365
type: SpeciesReference
stoichiometry: 1.0
species: 646618

646618
type: Species
notes: FORMULA: C27H48O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha,26-Trihydroxy-5beta-cholestane

045377
type: SpeciesReference
stoichiometry: 2.0
species: 645704

045341
type: SpeciesReference
stoichiometry: 1.0
species: 646019

045353
type: SpeciesReference
stoichiometry: 1.0
species: 646061

045389
type: SpeciesReference
stoichiometry: 1.0
species: 646013

045401
type: SpeciesReference
stoichiometry: 1.0
species: 646616

646616
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al

045329
type: SpeciesReference
stoichiometry: 1.0
species: 645716

652811
type: LocalParameter
units: 032971
value: 500.0

652808
type: LocalParameter
value: 0.0

652805
type: LocalParameter
units: 033007
value: 1000.0

652802
type: LocalParameter
units: 033007
value: 0.0

649516
type: Reaction
kinetic law: 110113
product: 110101
product: 110065
reactant: 110017
fast: false
reactant: 110053
reactant: 110029
product: 110077
product: 110089
reactant: 110041
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 3295.1 and 30.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 30.1 and 1962.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
reversible: false
name: Beta oxidation of long chain fatty acid

659635
type: LocalParameter
units: 032971
value: 500.0

659634
type: LocalParameter
value: 0.0

659632
type: LocalParameter
units: 033007
value: 1000.0

659631
type: LocalParameter
units: 033007
value: 0.0

110101
type: SpeciesReference
stoichiometry: 1.0
species: 646498

110065
type: SpeciesReference
stoichiometry: 1.0
species: 644944

110017
type: SpeciesReference
stoichiometry: 1.0
species: 645130

645130
type: Species
notes: FORMULA: C43H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: cervonyl coenzyme A

110053
type: SpeciesReference
stoichiometry: 1.0
species: 646003

110029
type: SpeciesReference
stoichiometry: 1.0
species: 645227

110077
type: SpeciesReference
stoichiometry: 1.0
species: 645721

110089
type: SpeciesReference
stoichiometry: 1.0
species: 646009

110041
type: SpeciesReference
stoichiometry: 1.0
species: 645709

648775
type: Reaction
kinetic law: 094368
product: 094356
reactant: 094344
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: Diphosphate transporter, endoplasmic reticulum

658275
type: LocalParameter
units: 032971
value: 0.0

658274
type: LocalParameter
value: 0.0

658273
type: LocalParameter
units: 033007
value: 1000.0

658272
type: LocalParameter
units: 033007
value: -1000.0

094356
type: SpeciesReference
stoichiometry: 1.0
species: 646226

646226
type: Species
notes: FORMULA: HO7P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: Diphosphate

094344
type: SpeciesReference
stoichiometry: 1.0
species: 646222

645104
type: Species
notes: FORMULA: C4H7O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: (R)-3-Hydroxybutanoate

644843
type: Species
notes: FORMULA: C44H49N12O21
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: haxglutamyl folate (DHF)

646567
type: Species
notes: FORMULA: CH4N2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Urea

646974
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: mepi_b

647795
type: Reaction
kinetic law: 060209
product: 060197
reactant: 060185
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: 4-aminobutanoate mitochondrial transport via diffusion

654757
type: LocalParameter
units: 032971
value: 0.0

654755
type: LocalParameter
value: 0.0

654753
type: LocalParameter
units: 033007
value: 1000.0

654751
type: LocalParameter
units: 033007
value: -1000.0

060197
type: SpeciesReference
stoichiometry: 1.0
species: 644764

060185
type: SpeciesReference
stoichiometry: 1.0
species: 644762

650458
type: Reaction
product: 129653
reactant: 129628
name: carnitine O-acetyltransferase, reverse direction, peroxisomal
product: 129640
notes: GENE_ASSOCIATION: (1384.2) GENE_LIST: 1384.2 SUBSYSTEM: Fatty Acid Metabolism
kinetic law: 129665
fast: false
reactant: 129616
reversible: true

129653
type: SpeciesReference
stoichiometry: 1.0
species: 645227

129628
type: SpeciesReference
stoichiometry: 1.0
species: 645248

645248
type: Species
notes: FORMULA: C7H15NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: L-Carnitine

129640
type: SpeciesReference
stoichiometry: 1.0
species: 644965

644965
type: Species
notes: FORMULA: C9H17NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: O-Acetylcarnitine

661536
type: LocalParameter
units: 032971
value: 0.0

661534
type: LocalParameter
value: 0.0

661533
type: LocalParameter
units: 033007
value: 1000.0

661531
type: LocalParameter
units: 033007
value: -1000.0

129616
type: SpeciesReference
stoichiometry: 1.0
species: 644944

650755
type: Reaction
reactant: 138855
product: 138915
product: 138891
reversible: true
notes: GENE_ASSOCIATION: (2180.1) GENE_LIST: 2180.1 SUBSYSTEM: Fatty acid activation
fast: false
product: 138903
kinetic law: 138927
name: fatty-acid--CoA ligase
reactant: 138867
reactant: 138879

138855
type: SpeciesReference
stoichiometry: 1.0
species: 645059

645059
type: Species
notes: FORMULA: C20H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: arachidonic acid

138915
type: SpeciesReference
stoichiometry: 1.0
species: 646222

138891
type: SpeciesReference
stoichiometry: 1.0
species: 645037

138903
type: SpeciesReference
stoichiometry: 1.0
species: 645062

662359
type: LocalParameter
units: 032971
value: 0.0

662357
type: LocalParameter
value: 0.0

662355
type: LocalParameter
units: 033007
value: 1000.0

662354
type: LocalParameter
units: 033007
value: -1000.0

138867
type: SpeciesReference
stoichiometry: 1.0
species: 645088

138879
type: SpeciesReference
stoichiometry: 1.0
species: 645223

650547
type: Reaction
product: 132226
reactant: 132190
product: 132238
reactant: 132202
reversible: true
name: testicular 17-beta-hydroxysteroid dehydrogenase
notes: GENE_ASSOCIATION: (3292.1) or (7923.1) GENE_LIST: 3292.1 7923.1 SUBSYSTEM: Steroid Metabolism
reactant: 132214
fast: false
kinetic law: 132250

132226
type: SpeciesReference
stoichiometry: 1.0
species: 645482

132190
type: SpeciesReference
stoichiometry: 1.0
species: 645485

645485
type: Species
notes: FORMULA: C18H22O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Estrone

132238
type: SpeciesReference
stoichiometry: 1.0
species: 646010

132202
type: SpeciesReference
stoichiometry: 1.0
species: 645712

132214
type: SpeciesReference
stoichiometry: 1.0
species: 646018

661783
type: LocalParameter
units: 032971
value: 0.0

661782
type: LocalParameter
value: 0.0

661780
type: LocalParameter
units: 033007
value: 1000.0

661779
type: LocalParameter
units: 033007
value: -1000.0

649765
type: Reaction
notes: GENE_ASSOCIATION: (60386.1) GENE_LIST: 60386.1 SUBSYSTEM: Transport, Mitochondrial
product: 114701
fast: false
product: 114714
name: dGTP transport via dCDP antiport
reversible: false
reactant: 114689
kinetic law: 114726
reactant: 114677

114701
type: SpeciesReference
stoichiometry: 1.0
species: 645295

114714
type: SpeciesReference
stoichiometry: 1.0
species: 645347

114689
type: SpeciesReference
stoichiometry: 1.0
species: 645346

660087
type: LocalParameter
units: 032971
value: 500.0

660085
type: LocalParameter
value: 0.0

660084
type: LocalParameter
units: 033007
value: 1000.0

660082
type: LocalParameter
units: 033007
value: 0.0

114677
type: SpeciesReference
stoichiometry: 1.0
species: 645296

647173
type: Reaction
notes: GENE_ASSOCIATION: (2805.1) GENE_LIST: 2805.1 SUBSYSTEM: Cysteine Metabolism
reactant: 035181
kinetic law: 035229
name: L-Cysteate:2-oxoglutarate aminotransferase
reversible: true
reactant: 035193
product: 035217
product: 035205
fast: false

035181
type: SpeciesReference
stoichiometry: 1.0
species: 644875

644875
type: Species
notes: FORMULA: C3H6NO5S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Cysteate

651185
type: LocalParameter
units: 032971
value: 0.0

651182
type: LocalParameter
value: 0.0

651179
type: LocalParameter
units: 033007
value: 1000.0

651178
type: LocalParameter
units: 033007
value: -1000.0

035193
type: SpeciesReference
stoichiometry: 1.0
species: 645010

645010
type: Species
notes: FORMULA: C5H4O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2-Oxoglutarate

035217
type: SpeciesReference
stoichiometry: 1.0
species: 645611

035205
type: SpeciesReference
stoichiometry: 1.0
species: 644758

644758
type: Species
notes: FORMULA: C3H2O6S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Sulfopyruvate

646090
type: Species
notes: FORMULA: C39H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: trans-Octadec-2-enoyl-CoA

649399
type: Reaction
kinetic law: 107485
product: 107473
reactant: 107461
fast: false
reversible: true
name: Glycine exchange

659422
type: LocalParameter
units: 032971
value: 0.0

659421
type: LocalParameter
value: 0.0

659419
type: LocalParameter
units: 033007
value: 1000.0

659418
type: LocalParameter
units: 033007
value: -1000.0

107473
type: SpeciesReference
stoichiometry: 1.0
species: 646995

646995
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ocdca_b

107461
type: SpeciesReference
stoichiometry: 1.0
species: 645629

645629
type: Species
notes: FORMULA: C2H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Glycine

649054
type: Reaction
reversible: false
reactant: 100662
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
product: 100698
kinetic law: 100710
reactant: 100674
product: 100686
fast: false
name: C161 transport into the mitochondria

100662
type: SpeciesReference
stoichiometry: 1.0
species: 645224

100698
type: SpeciesReference
stoichiometry: 1.0
species: 645748

645748
type: Species
notes: FORMULA: C37H60N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Hexadecenoyl-CoA (n-C16:1CoA)

658814
type: LocalParameter
units: 032971
value: 500.0

658813
type: LocalParameter
value: 0.0

658812
type: LocalParameter
units: 033007
value: 1000.0

658811
type: LocalParameter
units: 033007
value: 0.0

100674
type: SpeciesReference
stoichiometry: 1.0
species: 645745

645745
type: Species
notes: FORMULA: C23H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Hexadecenoyl carnitine

100686
type: SpeciesReference
stoichiometry: 1.0
species: 645247

648967
type: Reaction
reactant: 099007
product: 099031
reactant: 099019
kinetic law: 099055
reversible: false
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
product: 099043
fast: false
name: R group transport into the mitochondria

099007
type: SpeciesReference
stoichiometry: 1.0
species: 644908

644908
type: Species
notes: FORMULA: CO2FULLRC7H14NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: R total carnitine

099031
type: SpeciesReference
stoichiometry: 1.0
species: 644905

644905
type: Species
notes: FORMULA: CO2FULLRC21H31N7O15P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: R total Coenzyme A

099019
type: SpeciesReference
stoichiometry: 1.0
species: 645224

658679
type: LocalParameter
units: 032971
value: 500.0

658678
type: LocalParameter
value: 0.0

658677
type: LocalParameter
units: 033007
value: 1000.0

658676
type: LocalParameter
units: 033007
value: 0.0

099043
type: SpeciesReference
stoichiometry: 1.0
species: 645247

649099
type: Reaction
product: 101503
fast: false
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
reactant: 101479
reactant: 101491
reversible: true
product: 101515
name: cytidylate kinase (CMP,dATP),nuclear
kinetic law: 101527

101503
type: SpeciesReference
stoichiometry: 1.0
species: 645151

101479
type: SpeciesReference
stoichiometry: 1.0
species: 645209

101491
type: SpeciesReference
stoichiometry: 1.0
species: 645290

101515
type: SpeciesReference
stoichiometry: 1.0
species: 645280

658890
type: LocalParameter
units: 032971
value: 0.0

658889
type: LocalParameter
value: 0.0

658888
type: LocalParameter
units: 033007
value: 1000.0

658887
type: LocalParameter
units: 033007
value: -1000.0

650231
type: Reaction
reversible: true
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
kinetic law: 123870
fast: false
product: 123845
reactant: 123821
name: cytidylate kinase (dCMP,UTP)
product: 123858
reactant: 123833

660991
type: LocalParameter
units: 032971
value: 0.0

660990
type: LocalParameter
value: 0.0

660988
type: LocalParameter
units: 033007
value: 1000.0

660987
type: LocalParameter
units: 033007
value: -1000.0

123845
type: SpeciesReference
stoichiometry: 1.0
species: 645295

123821
type: SpeciesReference
stoichiometry: 1.0
species: 645301

123858
type: SpeciesReference
stoichiometry: 1.0
species: 646535

123833
type: SpeciesReference
stoichiometry: 1.0
species: 646574

647555
type: Reaction
kinetic law: 050275
product: 050262
reactant: 050250
notes: GENE_ASSOCIATION: (2544.1) GENE_LIST: 2544.1 SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: phosphate transport, endoplasmic reticulum

653608
type: LocalParameter
units: 032971
value: 0.0

653606
type: LocalParameter
value: 0.0

653604
type: LocalParameter
units: 033007
value: 1000.0

653602
type: LocalParameter
units: 033007
value: -1000.0

050262
type: SpeciesReference
stoichiometry: 1.0
species: 646193

050250
type: SpeciesReference
stoichiometry: 1.0
species: 646199

647644
type: Reaction
product: 053878
reactant: 053830
reactant: 053854
fast: false
kinetic law: 053902
reactant: 053842
product: 053866
product: 053890
reversible: false
notes: GENE_ASSOCIATION: (2180.1) or (2181.2) or (2181.1) GENE_LIST: 2180.1 2181.1 2181.2 SUBSYSTEM: Fatty acid activation
name: C181 fatty acid activation

053878
type: SpeciesReference
stoichiometry: 1.0
species: 646091

646091
type: Species
notes: FORMULA: C39H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Octadecenoyl-CoA (n-C18:1CoA)

053830
type: SpeciesReference
stoichiometry: 1.0
species: 645088

053854
type: SpeciesReference
stoichiometry: 1.0
species: 646082

646082
type: Species
notes: FORMULA: C18H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: octadecenoate (n-C18:1)

654050
type: LocalParameter
units: 032971
value: 500.0

654048
type: LocalParameter
value: 0.0

654046
type: LocalParameter
units: 033007
value: 1000.0

654044
type: LocalParameter
units: 033007
value: 0.0

053842
type: SpeciesReference
stoichiometry: 1.0
species: 645223

053866
type: SpeciesReference
stoichiometry: 1.0
species: 645037

053890
type: SpeciesReference
stoichiometry: 1.0
species: 646222

648074
type: Reaction
kinetic law: 071459
product: 071447
reactant: 071435
reactant: 071422
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
fast: false
reversible: true
name: cytidylate kinase (dCMP,dCTP),nuclear

656106
type: LocalParameter
units: 032971
value: 0.0

656104
type: LocalParameter
value: 0.0

656102
type: LocalParameter
units: 033007
value: 1000.0

656100
type: LocalParameter
units: 033007
value: -1000.0

071447
type: SpeciesReference
stoichiometry: 2.0
species: 645298

071435
type: SpeciesReference
stoichiometry: 1.0
species: 645317

071422
type: SpeciesReference
stoichiometry: 1.0
species: 645302

645302
type: Species
notes: FORMULA: C9H12N3O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: dCMP

647987
type: Reaction
fast: false
reversible: false
reactant: 067709
reactant: 067721
product: 067746
product: 067733
notes: GENE_ASSOCIATION: (3628.1) GENE_LIST: 3628.1 SUBSYSTEM: Inositol Phosphate Metabolism
kinetic law: 067758
name: inositol-1,3,4-trisphosphate 1-phosphatase

067709
type: SpeciesReference
stoichiometry: 1.0
species: 645700

067721
type: SpeciesReference
stoichiometry: 1.0
species: 645964

645964
type: Species
notes: FORMULA: C6H9O15P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 1,3,4-trisphosphate

067746
type: SpeciesReference
stoichiometry: 1.0
species: 646193

067733
type: SpeciesReference
stoichiometry: 1.0
species: 645971

645971
type: Species
notes: FORMULA: C6H10O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 3,4-bisphosphate

655706
type: LocalParameter
units: 032971
value: 500.0

655704
type: LocalParameter
value: 0.0

655702
type: LocalParameter
units: 033007
value: 1000.0

655700
type: LocalParameter
units: 033007
value: 0.0

645838
type: Species
notes: FORMULA: C9H14O12P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate

646528
type: Species
notes: FORMULA: C8H11NO4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Tyramine O-sulfate

647524
type: Reaction
reversible: false
name: 5'-nucleotidase (CMP), extracellular
reactant: 049105
product: 049129
fast: false
notes: GENE_ASSOCIATION: (4907.1) GENE_LIST: 4907.1 SUBSYSTEM: Nucleotides
product: 049141
reactant: 049117
kinetic law: 049153

049105
type: SpeciesReference
stoichiometry: 1.0
species: 645206

049129
type: SpeciesReference
stoichiometry: 1.0
species: 645269

645269
type: Species
notes: FORMULA: C9H13N3O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Cytidine

049141
type: SpeciesReference
stoichiometry: 1.0
species: 646195

049117
type: SpeciesReference
stoichiometry: 1.0
species: 645701

653443
type: LocalParameter
units: 032971
value: 500.0

653441
type: LocalParameter
value: 0.0

653439
type: LocalParameter
units: 033007
value: 1000.0

653437
type: LocalParameter
units: 033007
value: 0.0

645458
type: Species
notes: FORMULA: C32H39NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: ebastine

647569
type: Reaction
kinetic law: 050845
name: Deoxyadenosine deaminase
product: 050833
reactant: 050809
reactant: 050785
reactant: 050797
fast: false
reversible: false
notes: GENE_ASSOCIATION: (100.1) GENE_LIST: 100.1 SUBSYSTEM: Nucleotides
product: 050821

653680
type: LocalParameter
units: 032971
value: 500.0

653677
type: LocalParameter
value: 0.0

653675
type: LocalParameter
units: 033007
value: 1000.0

653672
type: LocalParameter
units: 033007
value: 0.0

050833
type: SpeciesReference
stoichiometry: 1.0
species: 646027

050809
type: SpeciesReference
stoichiometry: 1.0
species: 645712

050785
type: SpeciesReference
stoichiometry: 1.0
species: 645274

050797
type: SpeciesReference
stoichiometry: 1.0
species: 645700

050821
type: SpeciesReference
stoichiometry: 1.0
species: 645382

646133
type: Species
notes: FORMULA: C9H14O15P3FULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: phosphatidylinositol-3,4-bisphosphate (Homo sapiens)

648088
type: Reaction
kinetic law: 071929
product: 071917
reactant: 071904
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: false
name: gulonolactone endoplasmic reticular transport

656169
type: LocalParameter
units: 032971
value: 500.0

656167
type: LocalParameter
value: 0.0

656165
type: LocalParameter
units: 033007
value: 1000.0

656163
type: LocalParameter
units: 033007
value: 0.0

071917
type: SpeciesReference
stoichiometry: 1.0
species: 645685

645685
type: Species
notes: FORMULA: C6H10O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: L-Gulono-1,4-lactone

071904
type: SpeciesReference
stoichiometry: 1.0
species: 645683

645683
type: Species
notes: FORMULA: C6H10O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Gulono-1,4-lactone

646615
type: Species
notes: FORMULA: C27H48O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 3alpha,7alpha-Dihydroxy-5beta-cholestane

647291
type: Reaction
kinetic law: 040248
product: 040236
reactant: 040224
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: Retinol transport via faciliated diffusion

651929
type: LocalParameter
units: 032971
value: 500.0

651926
type: LocalParameter
value: 0.0

651923
type: LocalParameter
units: 033007
value: 1000.0

651920
type: LocalParameter
units: 033007
value: 0.0

040236
type: SpeciesReference
stoichiometry: 1.0
species: 646298

040224
type: SpeciesReference
stoichiometry: 1.0
species: 646300

646300
type: Species
notes: FORMULA: C20H30O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Retinol

644984
type: Species
notes: FORMULA: C15H21N5O14P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ADPribose

646220
type: Species
notes: FORMULA: C24H36N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Propanoyl-CoA

647416
type: Reaction
reversible: true
fast: false
product: 044955
name: bilirubin monoglucuronide transport via bicarbonate countertransport
product: 044967
reactant: 044929
notes: GENE_ASSOCIATION: (10599.1) or (28234.1) GENE_LIST: 10599.1 28234.1 SUBSYSTEM: Transport, Extracellular
reactant: 044942
kinetic law: 044979

044955
type: SpeciesReference
stoichiometry: 1.0
species: 645107

645107
type: Species
notes: FORMULA: C39H44N4O12
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Bilirubin monoglucuronide

044967
type: SpeciesReference
stoichiometry: 1.0
species: 645731

044929
type: SpeciesReference
stoichiometry: 1.0
species: 645109

645109
type: Species
notes: FORMULA: C39H44N4O12
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Bilirubin monoglucuronide

044942
type: SpeciesReference
stoichiometry: 1.0
species: 645730

652751
type: LocalParameter
units: 032971
value: 0.0

652748
type: LocalParameter
value: 0.0

652745
type: LocalParameter
units: 033007
value: 1000.0

652742
type: LocalParameter
units: 033007
value: -1000.0

650864
type: Reaction
kinetic law: 142114
product: 142102
reactant: 142090
fast: false
reversible: true
name: L-Histidine exchange

662677
type: LocalParameter
units: 032971
value: 0.0

662675
type: LocalParameter
value: 0.0

662673
type: LocalParameter
units: 033007
value: 1000.0

662672
type: LocalParameter
units: 033007
value: -1000.0

142102
type: SpeciesReference
stoichiometry: 1.0
species: 647118

647118
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: xoltri27_b

142090
type: SpeciesReference
stoichiometry: 1.0
species: 645770

645770
type: Species
notes: FORMULA: C6H9N3O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Histidine

646435
type: Species
notes: FORMULA: C24H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: tetracosapentaenoic acid, n-3

647498
type: Reaction
kinetic law: 048285
product: 048273
reactant: 048261
notes: GENE_ASSOCIATION: (3177.1) or (2030.1) GENE_LIST: 2030.1 3177.1 SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: uridine facilated transport in cytosol

653296
type: LocalParameter
units: 032971
value: 0.0

653293
type: LocalParameter
value: 0.0

653290
type: LocalParameter
units: 033007
value: 1000.0

653287
type: LocalParameter
units: 033007
value: -1000.0

048273
type: SpeciesReference
stoichiometry: 1.0
species: 646570

646570
type: Species
notes: FORMULA: C9H12N2O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Uridine

048261
type: SpeciesReference
stoichiometry: 1.0
species: 646571

645775
type: Species
notes: FORMULA: C27H39N7O20P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Hydroxymethylglutaryl-CoA

648473
type: Reaction
reactant: 084516
product: 084552
product: 084540
fast: false
reactant: 084528
kinetic law: 084564
reversible: false
notes: GENE_ASSOCIATION: (8836.1) GENE_LIST: 8836.1 SUBSYSTEM: Folate Metabolism
name: Gamma-glutamyl hydrolase (5DHF), extracellular

084516
type: SpeciesReference
stoichiometry: 1.0
species: 644809

644809
type: Species
notes: FORMULA: C39H43N11O18
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: pentaglutamyl folate (DHF)

084552
type: SpeciesReference
stoichiometry: 4.0
species: 645613

645613
type: Species
notes: FORMULA: C5H8NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Glutamate

084540
type: SpeciesReference
stoichiometry: 1.0
species: 645368

645368
type: Species
notes: FORMULA: C19H19N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 7,8-Dihydrofolate

084528
type: SpeciesReference
stoichiometry: 4.0
species: 645701

657481
type: LocalParameter
units: 032971
value: 500.0

657480
type: LocalParameter
value: 0.0

657479
type: LocalParameter
units: 033007
value: 1000.0

657478
type: LocalParameter
units: 033007
value: 0.0

644642
type: Species
notes: FORMULA: C20H21N7O7
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: 10-Formyltetrahydrofolate

647245
type: Reaction
reactant: 038099
product: 038111
kinetic law: 038135
notes: GENE_ASSOCIATION: (1807.1) or (1809.1) or (1808.1) GENE_LIST: 1807.1 1808.1 1809.1 SUBSYSTEM: Pyrimidine Catabolism
reversible: false
name: dihydropyrimidinase (5,6-dihydrouracil)
reactant: 038087
fast: false
product: 038123

038099
type: SpeciesReference
stoichiometry: 1.0
species: 645700

038111
type: SpeciesReference
stoichiometry: 1.0
species: 645134

651641
type: LocalParameter
units: 032971
value: 500.0

651638
type: LocalParameter
value: 0.0

651635
type: LocalParameter
units: 033007
value: 1000.0

651634
type: LocalParameter
units: 033007
value: 0.0

038087
type: SpeciesReference
stoichiometry: 1.0
species: 644803

644803
type: Species
notes: FORMULA: C4H6N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5,6-dihydrouracil

038123
type: SpeciesReference
stoichiometry: 1.0
species: 645712

647801
type: Reaction
product: 060416
reactant: 060379
fast: false
kinetic law: 060428
reactant: 060392
notes: GENE_ASSOCIATION: (36.1) or (34.1) GENE_LIST: 34.1 36.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
name: acyl-CoA dehydrogenase (2-methylbutanoyl-CoA), mitochondrial
product: 060404
reversible: false

060416
type: SpeciesReference
stoichiometry: 1.0
species: 645518

060379
type: SpeciesReference
stoichiometry: 1.0
species: 644686

654785
type: LocalParameter
units: 032971
value: 500.0

654783
type: LocalParameter
value: 0.0

654781
type: LocalParameter
units: 033007
value: 1000.0

654779
type: LocalParameter
units: 033007
value: 0.0

060392
type: SpeciesReference
stoichiometry: 1.0
species: 645512

060404
type: SpeciesReference
stoichiometry: 1.0
species: 644684

644684
type: Species
notes: FORMULA: C26H38N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: trans-2-Methylbut-2-enoyl-CoA

650222
type: Reaction
kinetic law: 123688
product: 123676
reactant: 123664
fast: false
reversible: true
name: Methylglyoxal exchange

660975
type: LocalParameter
units: 032971
value: 0.0

660973
type: LocalParameter
value: 0.0

660972
type: LocalParameter
units: 033007
value: 1000.0

660970
type: LocalParameter
units: 033007
value: -1000.0

123676
type: SpeciesReference
stoichiometry: 1.0
species: 647061

647061
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: taur_b

123664
type: SpeciesReference
stoichiometry: 1.0
species: 645986

645986
type: Species
notes: FORMULA: C3H4O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Methylglyoxal

646845
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: coumarin_b

647602
type: Reaction
product: 052196
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) GENE_LIST: 56301.1 6520.1 SUBSYSTEM: Transport, Extracellular
kinetic law: 052220
fast: false
name: L-alanine/glycine reversible exchange
reactant: 052172
product: 052208
reactant: 052184
reversible: true

052196
type: SpeciesReference
stoichiometry: 1.0
species: 645020

653854
type: LocalParameter
units: 032971
value: 0.0

653852
type: LocalParameter
value: 0.0

653850
type: LocalParameter
units: 033007
value: 1000.0

653848
type: LocalParameter
units: 033007
value: -1000.0

052172
type: SpeciesReference
stoichiometry: 1.0
species: 645022

645022
type: Species
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Alanine

052208
type: SpeciesReference
stoichiometry: 1.0
species: 645629

052184
type: SpeciesReference
stoichiometry: 1.0
species: 645628

648197
type: Reaction
name: phosphatidate cytidylyltransferase
notes: GENE_ASSOCIATION: (1040.1) GENE_LIST: 1040.1 SUBSYSTEM: Glycerophospholipid Metabolism
product: 075160
reversible: false
reactant: 075136
product: 075148
reactant: 075124
kinetic law: 075172
reactant: 075112
fast: false

075160
type: SpeciesReference
stoichiometry: 1.0
species: 646222

075136
type: SpeciesReference
stoichiometry: 1.0
species: 646120

075148
type: SpeciesReference
stoichiometry: 1.0
species: 645154

075124
type: SpeciesReference
stoichiometry: 1.0
species: 645712

656539
type: LocalParameter
units: 032971
value: 500.0

656537
type: LocalParameter
value: 0.0

656535
type: LocalParameter
units: 033007
value: 1000.0

656533
type: LocalParameter
units: 033007
value: 0.0

075112
type: SpeciesReference
stoichiometry: 1.0
species: 645254

647137
type: Reaction
notes: GENE_ASSOCIATION: (2180.1) GENE_LIST: 2180.1 SUBSYSTEM: Fatty acid activation
product: 033718
kinetic law: 033754
reversible: true
product: 033730
reactant: 033705
reactant: 033693
fast: false
product: 033742
reactant: 033681
name: fatty-acid--CoA ligase

033718
type: SpeciesReference
stoichiometry: 1.0
species: 645037

650977
type: LocalParameter
units: 032971
value: 0.0

650976
type: LocalParameter
value: 0.0

650973
type: LocalParameter
units: 033007
value: 1000.0

650972
type: LocalParameter
units: 033007
value: -1000.0

033730
type: SpeciesReference
stoichiometry: 1.0
species: 645052

033705
type: SpeciesReference
stoichiometry: 1.0
species: 645223

033693
type: SpeciesReference
stoichiometry: 1.0
species: 645088

033742
type: SpeciesReference
stoichiometry: 1.0
species: 646222

033681
type: SpeciesReference
stoichiometry: 1.0
species: 645049

645049
type: Species
notes: FORMULA: C20H39O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Arachidic acid

645508
type: Species
notes: FORMULA: C6H10O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Fructose 2,6-bisphosphate

033079
type: SBMLUnitsDef
unit: 033091
name: mmole

033091
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

647593
type: Reaction
kinetic law: 051932
product: 051920
reactant: 051908
fast: false
reversible: true
name: 1-alkyl 2-acteylglycerol 3-phosphocholine (homo sapiens) exchange

653812
type: LocalParameter
units: 032971
value: 0.0

653810
type: LocalParameter
value: 0.0

653808
type: LocalParameter
units: 033007
value: 1000.0

653806
type: LocalParameter
units: 033007
value: -1000.0

051920
type: SpeciesReference
stoichiometry: 1.0
species: 646821

646821
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: atp_b

051908
type: SpeciesReference
stoichiometry: 1.0
species: 646130

645113
type: Species
notes: FORMULA: C33H34N4O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Bilirubin

650798
type: Reaction
reactant: 140035
reversible: true
reactant: 140023
name: L-alanine/glutamine reversible exchange
fast: false
product: 140059
kinetic law: 140071
product: 140047
notes: GENE_ASSOCIATION: (56301.1) and (6520.1) GENE_LIST: 56301.1 6520.1 SUBSYSTEM: Transport, Extracellular

140035
type: SpeciesReference
stoichiometry: 1.0
species: 645604

645604
type: Species
notes: FORMULA: C5H10N2O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Glutamine

140023
type: SpeciesReference
stoichiometry: 1.0
species: 645017

645017
type: Species
notes: FORMULA: C3H7NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: D-Alanine

140059
type: SpeciesReference
stoichiometry: 1.0
species: 645605

662485
type: LocalParameter
units: 032971
value: 0.0

662483
type: LocalParameter
value: 0.0

662481
type: LocalParameter
units: 033007
value: 1000.0

662480
type: LocalParameter
units: 033007
value: -1000.0

140047
type: SpeciesReference
stoichiometry: 1.0
species: 645016

648925
type: Reaction
kinetic law: 097922
product: 097910
reactant: 097897
fast: false
reversible: true
name: Deoxyribose exchange

658600
type: LocalParameter
units: 032971
value: 0.0

658599
type: LocalParameter
value: 0.0

658598
type: LocalParameter
units: 033007
value: 1000.0

658597
type: LocalParameter
units: 033007
value: -1000.0

097910
type: SpeciesReference
stoichiometry: 1.0
species: 646956

646956
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: leu_DASH_L_b

097897
type: SpeciesReference
stoichiometry: 1.0
species: 645418

645418
type: Species
notes: FORMULA: C5H10O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Deoxyribose

648181
type: Reaction
kinetic law: 074623
product: 074610
reactant: 074598
fast: false
reversible: true
name: taurochenodeoxycholate exchange

656483
type: LocalParameter
units: 032971
value: 0.0

656481
type: LocalParameter
value: 0.0

656479
type: LocalParameter
units: 033007
value: 1000.0

656477
type: LocalParameter
units: 033007
value: -1000.0

074610
type: SpeciesReference
stoichiometry: 1.0
species: 646881

646881
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: eicostet_b

074598
type: SpeciesReference
stoichiometry: 1.0
species: 646421

646789
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: ac_b

650099
type: Reaction
kinetic law: 121407
product: 121395
reactant: 121383
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: dCTP diffusion in nucleus

660749
type: LocalParameter
units: 032971
value: 0.0

660748
type: LocalParameter
value: 0.0

660746
type: LocalParameter
units: 033007
value: 1000.0

660745
type: LocalParameter
units: 033007
value: -1000.0

121395
type: SpeciesReference
stoichiometry: 1.0
species: 645317

121383
type: SpeciesReference
stoichiometry: 1.0
species: 645314

650782
type: Reaction
kinetic law: 139590
notes: GENE_ASSOCIATION: (51181.1) GENE_LIST: 51181.1 SUBSYSTEM: Pentose and Glucuronate Interconversions
product: 139578
name: xylulose reductase
reversible: true
reactant: 139530
reactant: 139542
product: 139566
fast: false
reactant: 139554

662437
type: LocalParameter
units: 032971
value: 0.0

662435
type: LocalParameter
value: 0.0

662433
type: LocalParameter
units: 033007
value: 1000.0

662432
type: LocalParameter
units: 033007
value: -1000.0

139578
type: SpeciesReference
stoichiometry: 1.0
species: 646655

646655
type: Species
notes: FORMULA: C5H12O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Xylitol

139530
type: SpeciesReference
stoichiometry: 1.0
species: 645712

139542
type: SpeciesReference
stoichiometry: 1.0
species: 646018

139566
type: SpeciesReference
stoichiometry: 1.0
species: 646010

139554
type: SpeciesReference
stoichiometry: 1.0
species: 646743

649723
type: Reaction
kinetic law: 113939
product: 113927
reactant: 113915
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: phosphatidylinositol nuclear transport (diffusion)

660010
type: LocalParameter
units: 032971
value: 0.0

660009
type: LocalParameter
value: 0.0

660007
type: LocalParameter
units: 033007
value: 1000.0

660006
type: LocalParameter
units: 033007
value: -1000.0

113927
type: SpeciesReference
stoichiometry: 1.0
species: 646145

646145
type: Species
notes: FORMULA: C9H16O9PFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644623
name: phosphatidylinositol (homo sapiens)

113915
type: SpeciesReference
stoichiometry: 1.0
species: 646144

646331
type: Species
notes: FORMULA: C3H7NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: L-Serine

650482
type: Reaction
product: 130355
product: 130343
kinetic law: 130367
fast: false
name: carnitine octadecenoyl transferase
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
reactant: 130318
reactant: 130330
reversible: false

130355
type: SpeciesReference
stoichiometry: 1.0
species: 646093

646093
type: Species
notes: FORMULA: C39H64N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Octadecenoyl-CoA (n-C18:1CoA)

130343
type: SpeciesReference
stoichiometry: 1.0
species: 645247

661602
type: LocalParameter
units: 032971
value: 500.0

661600
type: LocalParameter
value: 0.0

661599
type: LocalParameter
units: 033007
value: 1000.0

661597
type: LocalParameter
units: 033007
value: 0.0

130318
type: SpeciesReference
stoichiometry: 1.0
species: 645224

130330
type: SpeciesReference
stoichiometry: 1.0
species: 646097

646097
type: Species
notes: FORMULA: C25H47NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: octadecenoyl carnitine

646273
type: Species
notes: FORMULA: C8H8NO6P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Pyridoxal 5'-phosphate

650542
type: Reaction
kinetic law: 132082
product: 132070
reactant: 132058
fast: false
reversible: true
name: IMP exchange

661767
type: LocalParameter
units: 032971
value: 0.0

661765
type: LocalParameter
value: 0.0

661764
type: LocalParameter
units: 033007
value: 1000.0

661762
type: LocalParameter
units: 033007
value: -1000.0

132070
type: SpeciesReference
stoichiometry: 1.0
species: 647097

132058
type: SpeciesReference
stoichiometry: 1.0
species: 645815

645815
type: Species
notes: FORMULA: C10H11N4O8P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: IMP

647599
type: Reaction
kinetic law: 052100
product: 052088
reactant: 052076
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: xenobiotic transport

653840
type: LocalParameter
units: 032971
value: 0.0

653838
type: LocalParameter
value: 0.0

653836
type: LocalParameter
units: 033007
value: 1000.0

653834
type: LocalParameter
units: 033007
value: -1000.0

052088
type: SpeciesReference
stoichiometry: 1.0
species: 644999

644999
type: Species
notes: FORMULA: C17H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: aflatoxin B1

052076
type: SpeciesReference
stoichiometry: 1.0
species: 645001

645001
type: Species
notes: FORMULA: C17H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: aflatoxin B1

650884
type: Reaction
reactant: 142560
kinetic law: 142608
product: 142596
product: 142584
notes: GENE_ASSOCIATION: (4860.1) or (151531.1) GENE_LIST: 151531.1 4860.1 SUBSYSTEM: Nucleotides
reactant: 142572
reversible: true
name: deoxyuridine phosphorylase
fast: false

142560
type: SpeciesReference
stoichiometry: 1.0
species: 645442

662725
type: LocalParameter
units: 032971
value: 0.0

662723
type: LocalParameter
value: 0.0

662721
type: LocalParameter
units: 033007
value: 1000.0

662720
type: LocalParameter
units: 033007
value: -1000.0

142596
type: SpeciesReference
stoichiometry: 1.0
species: 646556

646556
type: Species
notes: FORMULA: C4H4N2O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Uracil

142584
type: SpeciesReference
stoichiometry: 1.0
species: 644678

644678
type: Species
notes: FORMULA: C5H9O7P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2-Deoxy-D-ribose 1-phosphate

142572
type: SpeciesReference
stoichiometry: 1.0
species: 646193

649430
type: Reaction
kinetic law: 108231
product: 108219
reactant: 108207
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: true
name: fatty acid intracellular transport

659481
type: LocalParameter
units: 032971
value: 0.0

659480
type: LocalParameter
value: 0.0

659479
type: LocalParameter
units: 033007
value: 1000.0

659478
type: LocalParameter
units: 033007
value: -1000.0

108219
type: SpeciesReference
stoichiometry: 1.0
species: 646438

646438
type: Species
notes: FORMULA: C45H68N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: tetracosapentaenoyl coenzyme A, n-3

108207
type: SpeciesReference
stoichiometry: 1.0
species: 646436

648032
type: Reaction
kinetic law: 069541
product: 069529
reactant: 069517
fast: false
reversible: true
name: de-Fuc form of PA6 exchange

655910
type: LocalParameter
units: 032971
value: 0.0

655908
type: LocalParameter
value: 0.0

655906
type: LocalParameter
units: 033007
value: 1000.0

655904
type: LocalParameter
units: 033007
value: -1000.0

069529
type: SpeciesReference
stoichiometry: 1.0
species: 646867

069517
type: SpeciesReference
stoichiometry: 1.0
species: 646319

646319
type: Species
notes: FORMULA: C84H135N6O61X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: de-Fuc form of PA6

647945
type: Reaction
kinetic law: 066150
product: 066138
reactant: 066126
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: ATP diffusion in nucleus

655457
type: LocalParameter
units: 032971
value: 0.0

655455
type: LocalParameter
value: 0.0

655453
type: LocalParameter
units: 033007
value: 1000.0

655451
type: LocalParameter
units: 033007
value: -1000.0

066138
type: SpeciesReference
stoichiometry: 1.0
species: 645092

066126
type: SpeciesReference
stoichiometry: 1.0
species: 645088

649063
type: Reaction
fast: false
product: 100855
notes: GENE_ASSOCIATION: (2519.1) GENE_LIST: 2519.1 SUBSYSTEM: Keratan sulfate degradation
name: alpha-fucosidase, extracellular
product: 100843
reactant: 100819
reversible: false
kinetic law: 100867
reactant: 100831

100855
type: SpeciesReference
stoichiometry: 1.0
species: 645839

645839
type: Species
notes: FORMULA: C241H383N17O209S12X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: keratan sulfate I, degradation product 1

100843
type: SpeciesReference
stoichiometry: 1.0
species: 645554

645554
type: Species
notes: FORMULA: C6H12O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Fucose

100819
type: SpeciesReference
stoichiometry: 1.0
species: 645701

658830
type: LocalParameter
units: 032971
value: 500.0

658829
type: LocalParameter
value: 0.0

658828
type: LocalParameter
units: 033007
value: 1000.0

658827
type: LocalParameter
units: 033007
value: 0.0

100831
type: SpeciesReference
stoichiometry: 1.0
species: 645841

645841
type: Species
notes: FORMULA: C247H393N17O213S12X
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: keratan sulfate I

645886
type: Species
notes: FORMULA: C25H45NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Linoleyl carnitine

647705
type: Reaction
kinetic law: 056602
product: 056590
reactant: 056578
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: leucine mitochondrial transport

654337
type: LocalParameter
units: 032971
value: 0.0

654335
type: LocalParameter
value: 0.0

654333
type: LocalParameter
units: 033007
value: 1000.0

654331
type: LocalParameter
units: 033007
value: -1000.0

056590
type: SpeciesReference
stoichiometry: 1.0
species: 645859

056578
type: SpeciesReference
stoichiometry: 1.0
species: 645856

650426
type: Reaction
kinetic law: 128595
product: 128582
reactant: 128569
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: 24 trihydroxy cholesterol transport

661448
type: LocalParameter
units: 032971
value: 0.0

661446
type: LocalParameter
value: 0.0

661445
type: LocalParameter
units: 033007
value: 1000.0

661443
type: LocalParameter
units: 033007
value: -1000.0

128582
type: SpeciesReference
stoichiometry: 1.0
species: 646636

646636
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 7-alpha,24(S)-Dihydroxycholesterol

128569
type: SpeciesReference
stoichiometry: 1.0
species: 646634

645973
type: Species
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1D-myo-Inositol 3-phosphate

650359
type: Reaction
kinetic law: 126890
product: 126878
reactant: 126866
fast: false
reversible: true
name: gamma-Tocopherol exchange

661266
type: LocalParameter
units: 032971
value: 0.0

661265
type: LocalParameter
value: 0.0

661263
type: LocalParameter
units: 033007
value: 1000.0

661262
type: LocalParameter
units: 033007
value: -1000.0

126878
type: SpeciesReference
stoichiometry: 1.0
species: 647074

647074
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: thf_b

126866
type: SpeciesReference
stoichiometry: 1.0
species: 646746

647564
type: Reaction
notes: GENE_ASSOCIATION: (3295.1 and 30.1 and 51.2) or (51.1 and 30.1 and 1962.1) or (30.1 and 51.2 and 1962.1) or (51.1 and 3295.1 and 30.1) GENE_LIST: 1962.1 30.1 3295.1 51.1 51.2 SUBSYSTEM: Fatty acid oxidation, peroxisome
reactant: 050566
reactant: 050603
reactant: 050578
product: 050676
reactant: 050591
name: Beta oxidation of long chain fatty acid
product: 050639
kinetic law: 050688
reversible: false
product: 050627
product: 050651
reactant: 050615
product: 050664
fast: false

050566
type: SpeciesReference
stoichiometry: 1.0
species: 644992

050603
type: SpeciesReference
stoichiometry: 1.0
species: 646003

050578
type: SpeciesReference
stoichiometry: 1.0
species: 645227

050676
type: SpeciesReference
stoichiometry: 1.0
species: 646009

050591
type: SpeciesReference
stoichiometry: 1.0
species: 645709

050639
type: SpeciesReference
stoichiometry: 1.0
species: 645065

645065
type: Species
notes: FORMULA: C41H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: C20:4-CoA

653652
type: LocalParameter
units: 032971
value: 500.0

653649
type: LocalParameter
value: 0.0

653647
type: LocalParameter
units: 033007
value: 1000.0

653645
type: LocalParameter
units: 033007
value: 0.0

050627
type: SpeciesReference
stoichiometry: 1.0
species: 644944

050651
type: SpeciesReference
stoichiometry: 1.0
species: 645698

050615
type: SpeciesReference
stoichiometry: 1.0
species: 646064

050664
type: SpeciesReference
stoichiometry: 1.0
species: 645721

644635
type: Species
notes: FORMULA: C45H51N12O22
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 10-formyltetrahydrofolate-[Glu](6)

650285
type: Reaction
notes: GENE_ASSOCIATION: (2356.1) GENE_LIST: 2356.1 SUBSYSTEM: Folate Metabolism
name: folylpolyglutamate synthetase (10fthf)
product: 124868
fast: false
reversible: false
product: 124904
product: 124880
product: 124892
kinetic law: 124917
reactant: 124856
reactant: 124831
reactant: 124844

124868
type: SpeciesReference
stoichiometry: 1.0
species: 644627

124904
type: SpeciesReference
stoichiometry: 4.0
species: 646193

124880
type: SpeciesReference
stoichiometry: 4.0
species: 644974

124892
type: SpeciesReference
stoichiometry: 4.0
species: 645712

661090
type: LocalParameter
units: 032971
value: 500.0

661089
type: LocalParameter
value: 0.0

661087
type: LocalParameter
units: 033007
value: 1000.0

661086
type: LocalParameter
units: 033007
value: 0.0

124856
type: SpeciesReference
stoichiometry: 4.0
species: 645611

124831
type: SpeciesReference
stoichiometry: 1.0
species: 644641

124844
type: SpeciesReference
stoichiometry: 4.0
species: 645088

645883
type: Species
notes: FORMULA: C39H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: linoleic coenzyme A

649834
type: Reaction
kinetic law: 116087
product: 116075
reactant: 116063
notes: SUBSYSTEM: Transport, Endoplasmic Reticular
fast: false
reversible: true
name: estrone intracellular transport

660213
type: LocalParameter
units: 032971
value: 0.0

660212
type: LocalParameter
value: 0.0

660210
type: LocalParameter
units: 033007
value: 1000.0

660209
type: LocalParameter
units: 033007
value: -1000.0

116075
type: SpeciesReference
stoichiometry: 1.0
species: 645485

116063
type: SpeciesReference
stoichiometry: 1.0
species: 645487

649690
type: Reaction
fast: false
reactant: 113277
reactant: 113241
reversible: false
notes: GENE_ASSOCIATION: (66002.1) GENE_LIST: 66002.1 SUBSYSTEM: CYP Metabolism
kinetic law: 113325
product: 113313
reactant: 113265
product: 113301
name: cytochrome p450 4F12/4F2
product: 113289
reactant: 113253

113277
type: SpeciesReference
stoichiometry: 1.0
species: 646063

113241
type: SpeciesReference
stoichiometry: 1.0
species: 645461

659950
type: LocalParameter
units: 032971
value: 500.0

659949
type: LocalParameter
value: 0.0

659947
type: LocalParameter
units: 033007
value: 1000.0

659946
type: LocalParameter
units: 033007
value: 0.0

113313
type: SpeciesReference
stoichiometry: 1.0
species: 646015

113265
type: SpeciesReference
stoichiometry: 1.0
species: 646021

113301
type: SpeciesReference
stoichiometry: 1.0
species: 645707

113289
type: SpeciesReference
stoichiometry: 1.0
species: 645466

645466
type: Species
notes: FORMULA: C32H39NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: hydroxylated ebastine

113253
type: SpeciesReference
stoichiometry: 1.0
species: 645719

649324
type: Reaction
kinetic law: 105952
reactant: 105916
product: 105940
name: galactose transport via sodium symport
fast: false
product: 105928
notes: GENE_ASSOCIATION: (6523.1) GENE_LIST: 6523.1 SUBSYSTEM: Transport, Extracellular
reversible: true
reactant: 105904

659287
type: LocalParameter
units: 032971
value: 0.0

659286
type: LocalParameter
value: 0.0

659285
type: LocalParameter
units: 033007
value: 1000.0

659284
type: LocalParameter
units: 033007
value: -1000.0

105916
type: SpeciesReference
stoichiometry: 2.0
species: 645989

105940
type: SpeciesReference
stoichiometry: 2.0
species: 645988

105928
type: SpeciesReference
stoichiometry: 1.0
species: 645568

105904
type: SpeciesReference
stoichiometry: 1.0
species: 645569

647653
type: Reaction
kinetic law: 054369
product: 054357
reactant: 054344
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: Tyramine O-sulfate transport (diffusion)

654092
type: LocalParameter
units: 032971
value: 500.0

654090
type: LocalParameter
value: 0.0

654088
type: LocalParameter
units: 033007
value: 1000.0

654086
type: LocalParameter
units: 033007
value: 0.0

054357
type: SpeciesReference
stoichiometry: 1.0
species: 646529

646529
type: Species
notes: FORMULA: C8H11NO4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Tyramine O-sulfate

054344
type: SpeciesReference
stoichiometry: 1.0
species: 646528

647870
type: Reaction
kinetic law: 063188
product: 063176
reactant: 063164
notes: GENE_ASSOCIATION: (788.1) GENE_LIST: 788.1 SUBSYSTEM: Carnitine shuttle
fast: false
reversible: false
name: transport into the mitochondria (carnitine)

655107
type: LocalParameter
units: 032971
value: 500.0

655105
type: LocalParameter
value: 0.0

655103
type: LocalParameter
units: 033007
value: 1000.0

655101
type: LocalParameter
units: 033007
value: 0.0

063176
type: SpeciesReference
stoichiometry: 1.0
species: 645058

645058
type: Species
notes: FORMULA: C27H53NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: arachidyl carnitine

063164
type: SpeciesReference
stoichiometry: 1.0
species: 645056

645056
type: Species
notes: FORMULA: C27H53NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: arachidyl carnitine

649369
type: Reaction
product: 106917
reactant: 106868
product: 106953
reversible: false
product: 106941
reactant: 106844
product: 106905
notes: GENE_ASSOCIATION: (6785.1) GENE_LIST: 6785.1 SUBSYSTEM: Fatty acid elongation
reactant: 106892
fast: false
kinetic law: 106966
name: fatty-acyl-CoA elongation (n-C20:5CoA)
product: 106929
reactant: 106880
reactant: 106856

106917
type: SpeciesReference
stoichiometry: 1.0
species: 645212

106868
type: SpeciesReference
stoichiometry: 4.0
species: 646018

106953
type: SpeciesReference
stoichiometry: 4.0
species: 646010

106941
type: SpeciesReference
stoichiometry: 3.0
species: 645700

106844
type: SpeciesReference
stoichiometry: 5.0
species: 645712

106905
type: SpeciesReference
stoichiometry: 1.0
species: 645202

106892
type: SpeciesReference
stoichiometry: 1.0
species: 646495

659368
type: LocalParameter
units: 032971
value: 500.0

659367
type: LocalParameter
value: 0.0

659366
type: LocalParameter
units: 033007
value: 1000.0

659365
type: LocalParameter
units: 033007
value: 0.0

106929
type: SpeciesReference
stoichiometry: 1.0
species: 645223

106880
type: SpeciesReference
stoichiometry: 1.0
species: 646060

106856
type: SpeciesReference
stoichiometry: 1.0
species: 645928

648218
type: Reaction
notes: GENE_ASSOCIATION: (52.1) or (52.3) or (52.2) GENE_LIST: 52.1 52.2 52.3 SUBSYSTEM: Riboflavin Metabolism
name: acid phosphatase (FMN)
reactant: 075679
kinetic law: 075715
fast: false
product: 075691
product: 075703
reversible: false
reactant: 075667

075679
type: SpeciesReference
stoichiometry: 1.0
species: 645700

656609
type: LocalParameter
units: 032971
value: 500.0

656607
type: LocalParameter
value: 0.0

656605
type: LocalParameter
units: 033007
value: 1000.0

656603
type: LocalParameter
units: 033007
value: 0.0

075691
type: SpeciesReference
stoichiometry: 1.0
species: 646193

075703
type: SpeciesReference
stoichiometry: 1.0
species: 646313

646313
type: Species
notes: FORMULA: C17H20N4O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Riboflavin

075667
type: SpeciesReference
stoichiometry: 1.0
species: 645536

647719
type: Reaction
reactant: 057183
kinetic law: 057219
reactant: 057170
reversible: false
fast: false
product: 057195
name: C161 transport into the mitochondria
notes: GENE_ASSOCIATION: (1376.1) GENE_LIST: 1376.1 SUBSYSTEM: Carnitine shuttle
product: 057207

057183
type: SpeciesReference
stoichiometry: 1.0
species: 645755

645755
type: Species
notes: FORMULA: C23H43NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: trans-Hexadec-2-enoyl carnitine

654400
type: LocalParameter
units: 032971
value: 500.0

654398
type: LocalParameter
value: 0.0

654396
type: LocalParameter
units: 033007
value: 1000.0

654394
type: LocalParameter
units: 033007
value: 0.0

057170
type: SpeciesReference
stoichiometry: 1.0
species: 645224

057195
type: SpeciesReference
stoichiometry: 1.0
species: 645247

057207
type: SpeciesReference
stoichiometry: 1.0
species: 645751

649879
type: Reaction
product: 116926
notes: SUBSYSTEM: Tetrahydrobiopterin
reactant: 116878
reversible: false
product: 116902
name: 6,7-dihydropteridine reduction
fast: false
reactant: 116890
kinetic law: 116938
product: 116914

116926
type: SpeciesReference
stoichiometry: 1.0
species: 646453

116878
type: SpeciesReference
stoichiometry: 1.0
species: 644828

116902
type: SpeciesReference
stoichiometry: 1.0
species: 645712

116890
type: SpeciesReference
stoichiometry: 1.0
species: 645352

645352
type: Species
notes: FORMULA: C9H13N5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 6,7-Dihydrobiopterin

660295
type: LocalParameter
units: 032971
value: 500.0

660294
type: LocalParameter
value: 0.0

660292
type: LocalParameter
units: 033007
value: 1000.0

660291
type: LocalParameter
units: 033007
value: 0.0

116914
type: SpeciesReference
stoichiometry: 1.0
species: 645976

645976
type: Species
notes: FORMULA: C20H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 5,10-Methylenetetrahydrofolate

644696
type: Species
notes: FORMULA: C6H6O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 2-Oxoadipate

645550
type: Species
notes: FORMULA: C15H25O7P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Farnesyl diphosphate

647570
type: Reaction
name: acyl-Coenzyme A oxidase 2, branched chain
product: 050893
notes: GENE_ASSOCIATION: (8309.1) GENE_LIST: 8309.1 SUBSYSTEM: Bile Acid Biosynthesis
fast: false
reactant: 050881
reactant: 050869
reactant: 050857
kinetic law: 050917
product: 050905
reversible: false

050893
type: SpeciesReference
stoichiometry: 1.0
species: 645515

645515
type: Species
notes: FORMULA: C27H31N9O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Flavin adenine dinucleotide oxidized

050881
type: SpeciesReference
stoichiometry: 0.5
species: 646064

050869
type: SpeciesReference
stoichiometry: 1.0
species: 645521

645521
type: Species
notes: FORMULA: C27H33N9O15P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Flavin adenine dinucleotide reduced

050857
type: SpeciesReference
stoichiometry: 1.0
species: 645358

645358
type: Species
notes: FORMULA: C48H74N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA

653689
type: LocalParameter
units: 032971
value: 500.0

653687
type: LocalParameter
value: 0.0

653684
type: LocalParameter
units: 033007
value: 1000.0

653681
type: LocalParameter
units: 033007
value: 0.0

050905
type: SpeciesReference
stoichiometry: 1.0
species: 646454

646454
type: Species
notes: FORMULA: C48H76N7O20P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA

650291
type: Reaction
product: 125049
fast: false
reactant: 125013
notes: GENE_ASSOCIATION: (51727.1) GENE_LIST: 51727.1 SUBSYSTEM: Nucleotides
reactant: 125025
product: 125037
name: UMP kinase (dATP)
kinetic law: 125061
reversible: true

125049
type: SpeciesReference
stoichiometry: 1.0
species: 646535

125013
type: SpeciesReference
stoichiometry: 1.0
species: 645287

125025
type: SpeciesReference
stoichiometry: 1.0
species: 646549

125037
type: SpeciesReference
stoichiometry: 1.0
species: 645277

661101
type: LocalParameter
units: 032971
value: 0.0

661100
type: LocalParameter
value: 0.0

661098
type: LocalParameter
units: 033007
value: 1000.0

661097
type: LocalParameter
units: 033007
value: -1000.0

649168
type: Reaction
kinetic law: 102782
product: 102770
reactant: 102758
notes: SUBSYSTEM: Transport, Nuclear
fast: false
reversible: true
name: phosphatidylinositol 4-phosphate nuclear transport (diffusion)

659012
type: LocalParameter
units: 032971
value: 0.0

659010
type: LocalParameter
value: 0.0

659009
type: LocalParameter
units: 033007
value: 1000.0

659007
type: LocalParameter
units: 033007
value: -1000.0

102770
type: SpeciesReference
stoichiometry: 1.0
species: 646141

102758
type: SpeciesReference
stoichiometry: 1.0
species: 646139

646139
type: Species
notes: FORMULA: C9H15O12P2FULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)

644783
type: Species
notes: FORMULA: C12H18N2O4S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 4 hydroxy tolbutamide

648389
type: Reaction
kinetic law: 081326
reversible: false
product: 081302
reactant: 081278
notes: GENE_ASSOCIATION: (1375.1) or (1375.3) or (1375.4) or (126129.1) or (1374.1) or (1375.2) GENE_LIST: 126129.1 1374.1 1375.1 1375.2 1375.3 1375.4 SUBSYSTEM: Carnitine shuttle
reactant: 081290
name: carnitine O-palmitoyltransferase
product: 081314
fast: false

657254
type: LocalParameter
units: 032971
value: 500.0

657253
type: LocalParameter
value: 0.0

657252
type: LocalParameter
units: 033007
value: 1000.0

657251
type: LocalParameter
units: 033007
value: 0.0

081302
type: SpeciesReference
stoichiometry: 1.0
species: 645223

081278
type: SpeciesReference
stoichiometry: 1.0
species: 645244

081290
type: SpeciesReference
stoichiometry: 1.0
species: 645883

081314
type: SpeciesReference
stoichiometry: 1.0
species: 645886

650132
type: Reaction
product: 121927
product: 121939
kinetic law: 121951
reactant: 121903
fast: false
reactant: 121891
name: ketohexokinase
reversible: false
notes: GENE_ASSOCIATION: (3795.1) or (3795.2) GENE_LIST: 3795.1 3795.2 SUBSYSTEM: Fructose and Mannose Metabolism
product: 121915

121927
type: SpeciesReference
stoichiometry: 1.0
species: 645506

645506
type: Species
notes: FORMULA: C6H11O9P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Fructose 1-phosphate

121939
type: SpeciesReference
stoichiometry: 1.0
species: 645712

660810
type: LocalParameter
units: 032971
value: 500.0

660808
type: LocalParameter
value: 0.0

660807
type: LocalParameter
units: 033007
value: 1000.0

660805
type: LocalParameter
units: 033007
value: 0.0

121903
type: SpeciesReference
stoichiometry: 1.0
species: 645551

645551
type: Species
notes: FORMULA: C6H12O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: D-Fructose

121891
type: SpeciesReference
stoichiometry: 1.0
species: 645088

121915
type: SpeciesReference
stoichiometry: 1.0
species: 644974

648554
type: Reaction
fast: false
reactant: 087885
product: 087933
name: 2-oxoglutarate dehydrogenase
reactant: 087909
product: 087921
kinetic law: 087957
product: 087945
reversible: false
notes: GENE_ASSOCIATION: (4967.1) and (1738.1 and 8050.1) and (1743.1) or (4967.2) and (1738.1 and 8050.1) and (1743.1) GENE_LIST: 1738.1 1743.1 4967.1 4967.2 8050.1 SUBSYSTEM: Citric Acid Cycle
reactant: 087897

087885
type: SpeciesReference
stoichiometry: 1.0
species: 645011

087933
type: SpeciesReference
stoichiometry: 1.0
species: 646006

087909
type: SpeciesReference
stoichiometry: 1.0
species: 645998

087921
type: SpeciesReference
stoichiometry: 1.0
species: 645215

657730
type: LocalParameter
units: 032971
value: 500.0

657729
type: LocalParameter
value: 0.0

657728
type: LocalParameter
units: 033007
value: 1000.0

657727
type: LocalParameter
units: 033007
value: 0.0

087945
type: SpeciesReference
stoichiometry: 1.0
species: 646391

087897
type: SpeciesReference
stoichiometry: 1.0
species: 645224

646388
type: Species
notes: FORMULA: C4H4O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Succinate

647584
type: Reaction
fast: false
kinetic law: 051568
reactant: 051520
reactant: 051532
name: nucleoside-diphosphate kinase (ATP:GDP), mitochondrial
notes: GENE_ASSOCIATION: (4833.1) GENE_LIST: 4833.1 SUBSYSTEM: Nucleotides
product: 051544
product: 051556
reversible: true

653770
type: LocalParameter
units: 032971
value: 0.0

653768
type: LocalParameter
value: 0.0

653766
type: LocalParameter
units: 033007
value: 1000.0

653764
type: LocalParameter
units: 033007
value: -1000.0

051520
type: SpeciesReference
stoichiometry: 1.0
species: 645091

051532
type: SpeciesReference
stoichiometry: 1.0
species: 645586

051544
type: SpeciesReference
stoichiometry: 1.0
species: 644977

051556
type: SpeciesReference
stoichiometry: 1.0
species: 645677

645677
type: Species
notes: FORMULA: C10H12N5O14P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: GTP

648143
type: Reaction
kinetic law: 073617
product: 073605
reactant: 073593
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: false
name: 7-glutamyl-THF transport,m mitochondrial

656378
type: LocalParameter
units: 032971
value: 500.0

656376
type: LocalParameter
value: 0.0

656374
type: LocalParameter
units: 033007
value: 1000.0

656373
type: LocalParameter
units: 033007
value: 0.0

073605
type: SpeciesReference
stoichiometry: 1.0
species: 644863

644863
type: Species
notes: FORMULA: C49H57N13O24
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: heptaglutamyl folate (THF)

073593
type: SpeciesReference
stoichiometry: 1.0
species: 644866

647456
type: Reaction
product: 046543
fast: false
kinetic law: 046567
reactant: 046519
name: Gamma-glutamyl hydrolase (10FTHF6GLU), lysosomal
reversible: false
notes: GENE_ASSOCIATION: (8836.1) GENE_LIST: 8836.1 SUBSYSTEM: Folate Metabolism
product: 046555
reactant: 046531

046543
type: SpeciesReference
stoichiometry: 1.0
species: 644629

644629
type: Species
notes: FORMULA: C40H45N11O19
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: 10-formyltetrahydrofolate-[Glu](5)

653017
type: LocalParameter
units: 032971
value: 500.0

653014
type: LocalParameter
value: 0.0

653011
type: LocalParameter
units: 033007
value: 1000.0

653008
type: LocalParameter
units: 033007
value: 0.0

046519
type: SpeciesReference
stoichiometry: 1.0
species: 644633

644633
type: Species
notes: FORMULA: C45H51N12O22
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: 10-formyltetrahydrofolate-[Glu](6)

046555
type: SpeciesReference
stoichiometry: 1.0
species: 645614

645614
type: Species
notes: FORMULA: C5H8NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: L-Glutamate

046531
type: SpeciesReference
stoichiometry: 1.0
species: 645703

645703
type: Species
notes: FORMULA: H2O
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644620
name: H2O

650686
type: Reaction
reactant: 136503
fast: false
product: 136540
reactant: 136515
product: 136528
notes: GENE_ASSOCIATION: (3990.1) or (9388.1) or (5407.1) or (8513.1) or (5408.1) or (5406.1) GENE_LIST: 3990.1 5406.1 5407.1 5408.1 8513.1 9388.1 SUBSYSTEM: Triacylglycerol Synthesis
product: 136552
name: lipase
kinetic law: 136564
reversible: false

136503
type: SpeciesReference
stoichiometry: 1.0
species: 645701

136540
type: SpeciesReference
stoichiometry: 1.0
species: 645283

645283
type: Species
notes: FORMULA: C3H6OFULLRCO2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: diacylglycerol (homo sapiens)

136515
type: SpeciesReference
stoichiometry: 1.0
species: 646399

646399
type: Species
notes: FORMULA: C3H5FULLRCO2FULLR2CO2FULLR3CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: triacylglycerol (homo sapiens)

136528
type: SpeciesReference
stoichiometry: 1.0
species: 644896

136552
type: SpeciesReference
stoichiometry: 1.0
species: 645713

662163
type: LocalParameter
units: 032971
value: 500.0

662161
type: LocalParameter
value: 0.0

662160
type: LocalParameter
units: 033007
value: 1000.0

662158
type: LocalParameter
units: 033007
value: 0.0

645391
type: Species
notes: FORMULA: C20H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: dihomo-gamma-linolenic acid (n-6)

648188
type: Reaction
kinetic law: 074925
product: 074913
reactant: 074901
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion

656511
type: LocalParameter
units: 032971
value: 0.0

656509
type: LocalParameter
value: 0.0

656507
type: LocalParameter
units: 033007
value: 1000.0

656505
type: LocalParameter
units: 033007
value: -1000.0

074913
type: SpeciesReference
stoichiometry: 1.0
species: 646433

646433
type: Species
notes: FORMULA: C24H37O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: tetracosapentaenoic acid, n-3

074901
type: SpeciesReference
stoichiometry: 1.0
species: 646435

646839
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: clpnd_b

647756
type: Reaction
kinetic law: 058738
product: 058725
reactant: 058712
fast: false
reversible: true
name: Retinoate exchange

654575
type: LocalParameter
units: 032971
value: 0.0

654573
type: LocalParameter
value: 0.0

654571
type: LocalParameter
units: 033007
value: 1000.0

654569
type: LocalParameter
units: 033007
value: -1000.0

058725
type: SpeciesReference
stoichiometry: 1.0
species: 646830

646830
type: Species
constant: false
boundary condition: true
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: btn_b

058712
type: SpeciesReference
stoichiometry: 1.0
species: 646303

647128
type: Reaction
kinetic law: 033333
product: 033321
reactant: 033309
notes: GENE_ASSOCIATION: (788.1) GENE_LIST: 788.1 SUBSYSTEM: Carnitine shuttle
fast: false
reversible: false
name: transport into the mitochondria (carnitine)

650935
type: LocalParameter
units: 032971
value: 500.0

650932
type: LocalParameter
value: 0.0

650931
type: LocalParameter
units: 033007
value: 1000.0

650928
type: LocalParameter
units: 033007
value: 0.0

033321
type: SpeciesReference
stoichiometry: 1.0
species: 646385

033309
type: SpeciesReference
stoichiometry: 1.0
species: 646384

646384
type: Species
notes: FORMULA: C25H41NO4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: stearidonyl carnitine

647845
type: Reaction
kinetic law: 062145
product: 062133
reactant: 062121
notes: SUBSYSTEM: Transport, Mitochondrial
fast: false
reversible: true
name: Isoleucine mitochondrial transport

654988
type: LocalParameter
units: 032971
value: 0.0

654986
type: LocalParameter
value: 0.0

654984
type: LocalParameter
units: 033007
value: 1000.0

654982
type: LocalParameter
units: 033007
value: -1000.0

062133
type: SpeciesReference
stoichiometry: 1.0
species: 645812

645812
type: Species
notes: FORMULA: C6H13NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: L-Isoleucine

062121
type: SpeciesReference
stoichiometry: 1.0
species: 645809

647192
type: Reaction
reactant: 035907
product: 035932
reversible: true
name: methylenetetrahydrofolate dehydrogenase (NADP), mitochondrial
fast: false
kinetic law: 035956
reactant: 035920
product: 035944
notes: GENE_ASSOCIATION: (25902.1) or (10797.1) GENE_LIST: 10797.1 25902.1 SUBSYSTEM: Folate Metabolism

035907
type: SpeciesReference
stoichiometry: 1.0
species: 645977

645977
type: Species
notes: FORMULA: C20H21N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 5,10-Methylenetetrahydrofolate

035932
type: SpeciesReference
stoichiometry: 1.0
species: 645958

645958
type: Species
notes: FORMULA: C20H20N7O6
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: 5,10-Methenyltetrahydrofolate

651289
type: LocalParameter
units: 032971
value: 0.0

651286
type: LocalParameter
value: 0.0

651283
type: LocalParameter
units: 033007
value: 1000.0

651282
type: LocalParameter
units: 033007
value: -1000.0

035920
type: SpeciesReference
stoichiometry: 1.0
species: 646013

035944
type: SpeciesReference
stoichiometry: 1.0
species: 646019

647134
type: Reaction
reactant: 033549
reversible: true
fast: false
product: 033573
kinetic law: 033597
product: 033585
notes: GENE_ASSOCIATION: (4191.1) GENE_LIST: 4191.1 SUBSYSTEM: Citric Acid Cycle
name: malate dehydrogenase, mitochondrial
reactant: 033537
product: 033561

033549
type: SpeciesReference
stoichiometry: 1.0
species: 645998

033573
type: SpeciesReference
stoichiometry: 1.0
species: 646006

650963
type: LocalParameter
units: 032971
value: 0.0

650962
type: LocalParameter
value: 0.0

650959
type: LocalParameter
units: 033007
value: 1000.0

650956
type: LocalParameter
units: 033007
value: -1000.0

033585
type: SpeciesReference
stoichiometry: 1.0
species: 646073

646073
type: Species
notes: FORMULA: C4H2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Oxaloacetate

033537
type: SpeciesReference
stoichiometry: 1.0
species: 645926

033561
type: SpeciesReference
stoichiometry: 1.0
species: 645716

648058
type: Reaction
reversible: false
kinetic law: 070729
fast: false
name: UDPglucuronate uridine-diphosphohydrolase
product: 070693
reactant: 070681
reactant: 070669
product: 070717
product: 070705
notes: SUBSYSTEM: Pentose and Glucuronate Interconversions

656029
type: LocalParameter
units: 032971
value: 500.0

656027
type: LocalParameter
value: 0.0

656025
type: LocalParameter
units: 033007
value: 1000.0

656023
type: LocalParameter
units: 033007
value: 0.0

070693
type: SpeciesReference
stoichiometry: 1.0
species: 645599

070681
type: SpeciesReference
stoichiometry: 1.0
species: 646546

646546
type: Species
notes: FORMULA: C15H19N2O18P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: UDP-D-glucuronate

070669
type: SpeciesReference
stoichiometry: 1.0
species: 645700

070717
type: SpeciesReference
stoichiometry: 1.0
species: 646535

070705
type: SpeciesReference
stoichiometry: 1.0
species: 645712

646409
type: Species
notes: FORMULA: C47H31NO14
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: paclitaxel

650743
type: Reaction
product: 138431
reactant: 138394
product: 138418
reactant: 138382
kinetic law: 138455
reactant: 138406
notes: GENE_ASSOCIATION: (7358.1) GENE_LIST: 7358.1 SUBSYSTEM: Starch and Sucrose Metabolism
product: 138443
fast: false
reversible: false
name: UDPglucose 6-dehydrogenase

138431
type: SpeciesReference
stoichiometry: 2.0
species: 646004

138394
type: SpeciesReference
stoichiometry: 2.0
species: 645995

138418
type: SpeciesReference
stoichiometry: 3.0
species: 645712

138382
type: SpeciesReference
stoichiometry: 1.0
species: 645700

662325
type: LocalParameter
units: 032971
value: 500.0

662323
type: LocalParameter
value: 0.0

662321
type: LocalParameter
units: 033007
value: 1000.0

662320
type: LocalParameter
units: 033007
value: 0.0

138406
type: SpeciesReference
stoichiometry: 1.0
species: 646541

138443
type: SpeciesReference
stoichiometry: 1.0
species: 646546

649933
type: Reaction
kinetic law: 118012
product: 118000
reactant: 117988
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: sphingosylphosphorylcholine transport (diffusion)

660394
type: LocalParameter
units: 032971
value: 0.0

660393
type: LocalParameter
value: 0.0

660391
type: LocalParameter
units: 033007
value: 1000.0

660390
type: LocalParameter
units: 033007
value: -1000.0

118000
type: SpeciesReference
stoichiometry: 1.0
species: 646343

646343
type: Species
notes: FORMULA: C23H50N2O5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: sphingosylphosphorylcholine (homo sapiens)

117988
type: SpeciesReference
stoichiometry: 1.0
species: 646342

646342
type: Species
notes: FORMULA: C23H50N2O5P
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: sphingosylphosphorylcholine (homo sapiens)

648118
type: Reaction
notes: GENE_ASSOCIATION: (22978.1) GENE_LIST: 22978.1 SUBSYSTEM: NAD Metabolism
reversible: false
fast: false
name: 5'-nucleotidase
reactant: 072955
product: 072979
reactant: 072967
product: 072991
kinetic law: 073003

072955
type: SpeciesReference
stoichiometry: 1.0
species: 645700

072979
type: SpeciesReference
stoichiometry: 1.0
species: 646034

072967
type: SpeciesReference
stoichiometry: 1.0
species: 646036

072991
type: SpeciesReference
stoichiometry: 1.0
species: 646193

656295
type: LocalParameter
units: 032971
value: 500.0

656293
type: LocalParameter
value: 0.0

656291
type: LocalParameter
units: 033007
value: 1000.0

656289
type: LocalParameter
units: 033007
value: 0.0

646471
type: Species
notes: FORMULA: C12H16N4O4PS
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: Thiamin monophosphate

645218
type: Species
notes: FORMULA: CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: CO2

650415
type: Reaction
reactant: 128340
reversible: false
notes: GENE_ASSOCIATION: (29920.1) or (65263.1) GENE_LIST: 29920.1 65263.1 SUBSYSTEM: Urea cycle/amino group metabolism
fast: false
reactant: 128352
product: 128364
kinetic law: 128388
product: 128376
reactant: 128328
name: pyrroline-5-carboxylate reductase

128340
type: SpeciesReference
stoichiometry: 2.0
species: 645712

128352
type: SpeciesReference
stoichiometry: 1.0
species: 646018

128364
type: SpeciesReference
stoichiometry: 1.0
species: 646010

661420
type: LocalParameter
units: 032971
value: 500.0

661419
type: LocalParameter
value: 0.0

661417
type: LocalParameter
units: 033007
value: 1000.0

661416
type: LocalParameter
units: 033007
value: 0.0

128376
type: SpeciesReference
stoichiometry: 1.0
species: 646240

128328
type: SpeciesReference
stoichiometry: 1.0
species: 644666

644666
type: Species
notes: FORMULA: C5H6NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 1-Pyrroline-5-carboxylate

650506
type: Reaction
reversible: false
kinetic law: 131030
product: 130982
product: 131018
product: 131006
reactant: 130958
notes: GENE_ASSOCIATION: (8714.3) or (8647.1) or (8714.2) or (8714.1) GENE_LIST: 8647.1 8714.1 8714.2 8714.3 SUBSYSTEM: Transport, Extracellular
fast: false
reactant: 130970
reactant: 130946
name: ABC bile acid transporter
product: 130994

661668
type: LocalParameter
units: 032971
value: 500.0

661666
type: LocalParameter
value: 0.0

661665
type: LocalParameter
units: 033007
value: 1000.0

661663
type: LocalParameter
units: 033007
value: 0.0

130982
type: SpeciesReference
stoichiometry: 1.0
species: 644974

131018
type: SpeciesReference
stoichiometry: 1.0
species: 646193

131006
type: SpeciesReference
stoichiometry: 1.0
species: 645712

130958
type: SpeciesReference
stoichiometry: 1.0
species: 645170

130970
type: SpeciesReference
stoichiometry: 1.0
species: 645700

130946
type: SpeciesReference
stoichiometry: 1.0
species: 645088

130994
type: SpeciesReference
stoichiometry: 1.0
species: 645172

647828
type: Reaction
name: UDP-glucuronosyltransferase 1-10 precursor, microsomal (13-cis)
product: 061455
kinetic law: 061479
product: 061467
notes: GENE_ASSOCIATION: (54576.1) or (54575.1) GENE_LIST: 54575.1 54576.1 SUBSYSTEM: Vitamin A Metabolism
reactant: 061443
fast: false
reactant: 061431
reversible: false

061455
type: SpeciesReference
stoichiometry: 1.0
species: 644654

644654
type: Species
notes: FORMULA: C26H35O8
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: 13-cis-retinoyl glucuronide

654911
type: LocalParameter
units: 032971
value: 500.0

654909
type: LocalParameter
value: 0.0

654907
type: LocalParameter
units: 033007
value: 1000.0

654905
type: LocalParameter
units: 033007
value: 0.0

061467
type: SpeciesReference
stoichiometry: 1.0
species: 646540

646540
type: Species
notes: FORMULA: C9H11N2O12P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: UDP

061443
type: SpeciesReference
stoichiometry: 1.0
species: 646547

646547
type: Species
notes: FORMULA: C15H19N2O18P2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644624
name: UDP-D-glucuronate

061431
type: SpeciesReference
stoichiometry: 1.0
species: 644650

645908
type: Species
notes: FORMULA: C8H15NOS2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Lipoamide

646229
type: Species
notes: FORMULA: C34H32N4O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Protoporphyrin

649393
type: Reaction
reversible: false
fast: false
product: 107377
reactant: 107353
notes: GENE_ASSOCIATION: (11164.1) GENE_LIST: 11164.1 SUBSYSTEM: Nucleotides
product: 107389
kinetic law: 107413
name: ADPribose diphosphatase
reactant: 107365
product: 107401

107377
type: SpeciesReference
stoichiometry: 1.0
species: 645037

107353
type: SpeciesReference
stoichiometry: 1.0
species: 644983

107389
type: SpeciesReference
stoichiometry: 2.0
species: 645712

659411
type: LocalParameter
units: 032971
value: 500.0

659410
type: LocalParameter
value: 0.0

659409
type: LocalParameter
units: 033007
value: 1000.0

659408
type: LocalParameter
units: 033007
value: 0.0

107365
type: SpeciesReference
stoichiometry: 1.0
species: 645700

107401
type: SpeciesReference
stoichiometry: 1.0
species: 646292

645101
type: Species
notes: FORMULA: C5H12NO
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: Betaine aldehyde

649681
type: Reaction
kinetic law: 113156
reactant: 113095
notes: GENE_ASSOCIATION: (3990.1) GENE_LIST: 3990.1 SUBSYSTEM: Fatty Acid Metabolism
product: 113144
reversible: false
reactant: 113108
product: 113132
fast: false
product: 113120
name: lipase, extracellular

659934
type: LocalParameter
units: 032971
value: 500.0

659932
type: LocalParameter
value: 0.0

659931
type: LocalParameter
units: 033007
value: 1000.0

659929
type: LocalParameter
units: 033007
value: 0.0

113095
type: SpeciesReference
stoichiometry: 1.0
species: 645701

113144
type: SpeciesReference
stoichiometry: 1.0
species: 645713

113108
type: SpeciesReference
stoichiometry: 1.0
species: 645923

645923
type: Species
notes: FORMULA: C3H7O2FULLR2CO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: monoacylglycerol 2 (homo sapiens)

113132
type: SpeciesReference
stoichiometry: 1.0
species: 645644

113120
type: SpeciesReference
stoichiometry: 1.0
species: 644891

644891
type: Species
notes: FORMULA: CO2FULLR2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: R total 2 position

647590
type: Reaction
product: 051836
notes: GENE_ASSOCIATION: (7173.4) or (7173.1) or (7173.3) or (7173.2) or (7173.5) GENE_LIST: 7173.1 7173.2 7173.3 7173.4 7173.5 SUBSYSTEM: Tyrosine metabolism
product: 051824
reactant: 051788
reactant: 051812
name: Iodide:hydrogen-peroxide oxidoreductase 3
fast: false
product: 051848
reversible: false
reactant: 051800
kinetic law: 051860

051836
type: SpeciesReference
stoichiometry: 2.0
species: 645700

051824
type: SpeciesReference
stoichiometry: 1.0
species: 644674

644674
type: Species
notes: FORMULA: C3H5NO2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 2-Aminoacrylate

051788
type: SpeciesReference
stoichiometry: 1.0
species: 644714

644714
type: Species
notes: FORMULA: C9H9I2NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3,5-Diiodo-L-tyrosine

051812
type: SpeciesReference
stoichiometry: 1.0
species: 645692

051848
type: SpeciesReference
stoichiometry: 1.0
species: 646508

051800
type: SpeciesReference
stoichiometry: 1.0
species: 644731

644731
type: Species
notes: FORMULA: C9H10INO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 3-Iodo-L-tyrosine

653798
type: LocalParameter
units: 032971
value: 500.0

653796
type: LocalParameter
value: 0.0

653794
type: LocalParameter
units: 033007
value: 1000.0

653792
type: LocalParameter
units: 033007
value: 0.0

646231
type: Species
notes: FORMULA: C34H38N4O4
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Protoporphyrinogen IX

647512
type: Reaction
kinetic law: 048730
product: 048718
reactant: 048706
fast: false
reversible: true
name: linoleic acid (all cis C18:2) exchange

653380
type: LocalParameter
units: 032971
value: 0.0

653377
type: LocalParameter
value: 0.0

653374
type: LocalParameter
units: 033007
value: 1000.0

653372
type: LocalParameter
units: 033007
value: -1000.0

048718
type: SpeciesReference
stoichiometry: 1.0
species: 646805

048706
type: SpeciesReference
stoichiometry: 1.0
species: 645881

645881
type: Species
notes: FORMULA: C18H31O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: linoleic acid (all cis C18:2) n-6

649228
type: Reaction
reversible: false
notes: GENE_ASSOCIATION: (53905.1) or (50506.1) or (53905.2) GENE_LIST: 50506.1 53905.1 53905.2 SUBSYSTEM: Tyrosine metabolism
name: Hydrogen peroxide synthesis (NADPH dependent)
fast: false
reactant: 103963
reactant: 103951
product: 103987
product: 103975
reactant: 103939
kinetic law: 104000

103963
type: SpeciesReference
stoichiometry: 1.0
species: 646060

103951
type: SpeciesReference
stoichiometry: 1.0
species: 646018

103987
type: SpeciesReference
stoichiometry: 1.0
species: 646010

103975
type: SpeciesReference
stoichiometry: 1.0
species: 645692

103939
type: SpeciesReference
stoichiometry: 1.0
species: 645712

659123
type: LocalParameter
units: 032971
value: 500.0

659122
type: LocalParameter
value: 0.0

659120
type: LocalParameter
units: 033007
value: 1000.0

659119
type: LocalParameter
units: 033007
value: 0.0

650819
type: Reaction
fast: false
product: 140784
kinetic law: 140808
reactant: 140760
name: L-carnitine inward transport by Na+ symport
notes: GENE_ASSOCIATION: (6584.1) GENE_LIST: 6584.1 SUBSYSTEM: Transport, Extracellular
reversible: false
reactant: 140772
product: 140796

140784
type: SpeciesReference
stoichiometry: 1.0
species: 645244

662551
type: LocalParameter
units: 032971
value: 500.0

662549
type: LocalParameter
value: 0.0

662547
type: LocalParameter
units: 033007
value: 1000.0

662546
type: LocalParameter
units: 033007
value: 0.0

140760
type: SpeciesReference
stoichiometry: 1.0
species: 645245

645245
type: Species
notes: FORMULA: C7H15NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: L-Carnitine

140772
type: SpeciesReference
stoichiometry: 1.0
species: 645989

140796
type: SpeciesReference
stoichiometry: 1.0
species: 645988

649738
type: Reaction
kinetic law: 114253
product: 114241
reactant: 114229
notes: GENE_ASSOCIATION: (84693.1) GENE_LIST: 84693.1 SUBSYSTEM: Valine, Leucine, and Isoleucine Metabolism
fast: false
reversible: true
name: methylmalonyl-CoA epimerase/racemase

660038
type: LocalParameter
units: 032971
value: 0.0

660036
type: LocalParameter
value: 0.0

660035
type: LocalParameter
units: 033007
value: 1000.0

660033
type: LocalParameter
units: 033007
value: -1000.0

114241
type: SpeciesReference
stoichiometry: 1.0
species: 645982

645982
type: Species
notes: FORMULA: C25H35N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (S)-Methylmalonyl-CoA

114229
type: SpeciesReference
stoichiometry: 1.0
species: 645980

645980
type: Species
notes: FORMULA: C25H35N7O19P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: (R)-Methylmalonyl-CoA

648541
type: Reaction
kinetic law: 087233
product: 087220
reactant: 087207
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: false
name: NADP transporter, peroxisome

657682
type: LocalParameter
units: 032971
value: 500.0

657681
type: LocalParameter
value: 0.0

657680
type: LocalParameter
units: 033007
value: 1000.0

657679
type: LocalParameter
units: 033007
value: 0.0

087220
type: SpeciesReference
stoichiometry: 1.0
species: 646010

087207
type: SpeciesReference
stoichiometry: 1.0
species: 646016

646016
type: Species
notes: FORMULA: C21H25N7O17P3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Nicotinamide adenine dinucleotide phosphate

645178
type: Species
notes: FORMULA: C48H76N7O20P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA

648076
type: Reaction
kinetic law: 071495
product: 071483
reactant: 071471
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: fatty acid transport via diffusion

656113
type: LocalParameter
units: 032971
value: 0.0

656111
type: LocalParameter
value: 0.0

656109
type: LocalParameter
units: 033007
value: 1000.0

656107
type: LocalParameter
units: 033007
value: -1000.0

071483
type: SpeciesReference
stoichiometry: 1.0
species: 645389

645389
type: Species
notes: FORMULA: C20H33O2
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: dihomo-gamma-linolenic acid (n-6)

071471
type: SpeciesReference
stoichiometry: 1.0
species: 645391

647989
type: Reaction
kinetic law: 067795
product: 067783
reactant: 067771
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: true
name: 25 trihydroxy cholesterol transport

655713
type: LocalParameter
units: 032971
value: 0.0

655711
type: LocalParameter
value: 0.0

655709
type: LocalParameter
units: 033007
value: 1000.0

655707
type: LocalParameter
units: 033007
value: -1000.0

067783
type: SpeciesReference
stoichiometry: 1.0
species: 646640

646640
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: 7-alpha,25-Dihydroxycholesterol

067771
type: SpeciesReference
stoichiometry: 1.0
species: 646639

646639
type: Species
notes: FORMULA: C27H46O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: 7-alpha,25-Dihydroxycholesterol

646315
type: Species
notes: FORMULA: C11H15N2O5
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: N-Ribosylnicotinamide

649654
type: Reaction
reactant: 112565
reactant: 112589
fast: false
reactant: 112577
kinetic law: 112637
reactant: 112553
product: 112613
product: 112601
notes: GENE_ASSOCIATION: (6319.1) GENE_LIST: 6319.1 SUBSYSTEM: Fatty acid elongation
reversible: false
product: 112625
name: stearoyl-CoA desaturase (n-C18:0CoA -> n-C18:1CoA)

112565
type: SpeciesReference
stoichiometry: 1.0
species: 646004

112589
type: SpeciesReference
stoichiometry: 1.0
species: 646366

112577
type: SpeciesReference
stoichiometry: 1.0
species: 646060

659886
type: LocalParameter
units: 032971
value: 500.0

659884
type: LocalParameter
value: 0.0

659883
type: LocalParameter
units: 033007
value: 1000.0

659881
type: LocalParameter
units: 033007
value: 0.0

112553
type: SpeciesReference
stoichiometry: 1.0
species: 645712

112613
type: SpeciesReference
stoichiometry: 1.0
species: 645995

112601
type: SpeciesReference
stoichiometry: 2.0
species: 645700

112625
type: SpeciesReference
stoichiometry: 1.0
species: 646088

647879
type: Reaction
kinetic law: 063586
product: 063574
reactant: 063562
fast: false
reversible: true
name: keratan sulfate I, degradation product 1 exchange

655149
type: LocalParameter
units: 032971
value: 0.0

655147
type: LocalParameter
value: 0.0

655145
type: LocalParameter
units: 033007
value: 1000.0

655143
type: LocalParameter
units: 033007
value: -1000.0

063574
type: SpeciesReference
stoichiometry: 1.0
species: 646849

063562
type: SpeciesReference
stoichiometry: 1.0
species: 645839

645844
type: Species
notes: FORMULA: C3H5O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644618
name: D-Lactate

645292
type: Species
notes: FORMULA: C31H50N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: Decanoyl-CoA (n-C10:0CoA)

648958
type: Reaction
fast: false
reversible: false
reactant: 098777
product: 098789
reactant: 098753
product: 098801
product: 098814
name: serine C-palmitoyltransferase
kinetic law: 098826
reactant: 098765
notes: GENE_ASSOCIATION: (10558.1 and 9517.1) GENE_LIST: 10558.1 9517.1 SUBSYSTEM: Sphingolipid Metabolism

098777
type: SpeciesReference
stoichiometry: 1.0
species: 646328

646328
type: Species
notes: FORMULA: C3H7NO3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644617
name: L-Serine

098789
type: SpeciesReference
stoichiometry: 1.0
species: 644722

098753
type: SpeciesReference
stoichiometry: 1.0
species: 645712

098801
type: SpeciesReference
stoichiometry: 1.0
species: 645212

098814
type: SpeciesReference
stoichiometry: 1.0
species: 645223

658663
type: LocalParameter
units: 032971
value: 500.0

658662
type: LocalParameter
value: 0.0

658661
type: LocalParameter
units: 033007
value: 1000.0

658660
type: LocalParameter
units: 033007
value: 0.0

098765
type: SpeciesReference
stoichiometry: 1.0
species: 646202

648461
type: Reaction
kinetic law: 084142
product: 084130
reactant: 084118
notes: SUBSYSTEM: Transport, Peroxisomal
fast: false
reversible: false
name: urate export from peroxisome

657449
type: LocalParameter
units: 032971
value: 500.0

657448
type: LocalParameter
value: 0.0

657447
type: LocalParameter
units: 033007
value: 1000.0

657446
type: LocalParameter
units: 033007
value: 0.0

084130
type: SpeciesReference
stoichiometry: 1.0
species: 646559

084118
type: SpeciesReference
stoichiometry: 1.0
species: 646562

646562
type: Species
notes: FORMULA: C5H4N4O3
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644626
name: Urate

647158
type: Reaction
reversible: false
kinetic law: 034599
product: 034587
name: choline phosphotransferase
reactant: 034539
product: 034575
fast: false
notes: GENE_ASSOCIATION: (10390.1) or (56994.1) GENE_LIST: 10390.1 56994.1 SUBSYSTEM: Glycerophospholipid Metabolism
product: 034563
reactant: 034551

651083
type: LocalParameter
units: 032971
value: 500.0

651082
type: LocalParameter
value: 0.0

651079
type: LocalParameter
units: 033007
value: 1000.0

651078
type: LocalParameter
units: 033007
value: 0.0

034587
type: SpeciesReference
stoichiometry: 1.0
species: 646151

034539
type: SpeciesReference
stoichiometry: 1.0
species: 645152

034575
type: SpeciesReference
stoichiometry: 1.0
species: 645712

034563
type: SpeciesReference
stoichiometry: 1.0
species: 645205

034551
type: SpeciesReference
stoichiometry: 1.0
species: 645281

648187
type: Reaction
product: 074864
reactant: 074804
reversible: false
reactant: 074780
product: 074876
product: 074852
product: 074840
fast: false
reactant: 074816
product: 074828
name: Beta oxidation fatty acid
reactant: 074792
kinetic law: 074888
reactant: 074767
notes: GENE_ASSOCIATION: (35.1) or (34.1) GENE_LIST: 34.1 35.1 SUBSYSTEM: Fatty acid oxidation

074864
type: SpeciesReference
stoichiometry: 1.0
species: 646006

074804
type: SpeciesReference
stoichiometry: 1.0
species: 645704

074780
type: SpeciesReference
stoichiometry: 1.0
species: 645472

645472
type: Species
notes: FORMULA: C41H62N7O17P3S
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 644621
name: eicosatetranoyl coenzyme A

074876
type: SpeciesReference
stoichiometry: 1.0
species: 646381

074852
type: SpeciesReference
stoichiometry: 1.0
species: 645716

074840
type: SpeciesReference
stoichiometry: 1.0
species: 645518

074816
type: SpeciesReference
stoichiometry: 1.0
species: 645998

074828
type: SpeciesReference
stoichiometry: 1.0
species: 644941

074792
type: SpeciesReference
stoichiometry: 1.0
species: 645512

656504
type: LocalParameter
units: 032971
value: 500.0

656502
type: LocalParameter
value: 0.0

656500
type: LocalParameter
units: 033007
value: 1000.0

656498
type: LocalParameter
units: 033007
value: 0.0

074767
type: SpeciesReference
stoichiometry: 1.0
species: 645224

648437
type: Reaction
kinetic law: 083441
product: 083429
reactant: 083417
notes: SUBSYSTEM: Transport, Extracellular
fast: false
reversible: false
name: Nicotinamide acid uptake