MODEL1008120003
type: SBMLModel
species: 326155
species: 328965
reaction: 975587
species: 314778
species: 315997
species: 315130
species: 329824
species: 331731
species: 310588
species: 305387
reaction: 967808
reaction: 967555
species: 307331
reaction: 971144
species: 318234
species: 319806
species: 311558
species: 306799
species: 318306
species: 323738
species: 329402
reaction: 976355
species: 312363
reaction: 975215
species: 323600
species: 330718
species: 327639
reaction: 976271
species: 314949
reaction: 974350
species: 305146
reaction: 969131
species: 325767
species: 331694
species: 315214
species: 307536
species: 328857
reaction: 968565
species: 326119
species: 318088
species: 315022
reaction: 969951
species: 326903
reaction: 972525
species: 330174
species: 331272
reaction: 967447
reaction: 977423
reaction: 976283
species: 305629
species: 304052
species: 326711
species: 309359
species: 323588
species: 309936
species: 310070
species: 305109
reaction: 971096
species: 327194
species: 331755
species: 317288
species: 331586
species: 310721
reaction: 976523
reaction: 971372
species: 329257
species: 327796
species: 304256
reaction: 974951
compartment: 303787
reaction: 968951
species: 324737
species: 331514
reaction: 976583
reaction: 966918
species: 321489
species: 329329
species: 328881
species: 326699

326155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylinositol-3,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2

303763
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

328965
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Sphinganine 1-phosphate_C18H39NO5P

303775
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

975587
type: Reaction
reactant: 415284
product: 415333
fast: false
reactant: 415296
reactant: 415272
reversible: true
notes: R_GLYt7_LPAREN_211_RPAREN_r subsystem: Transport, Extracellular R_GLYt7_LPAREN_211_RPAREN_r equation: cl[e] + gly[e] + (2) na1[e] <==> cl[c] + gly[c] + (2) na1[c]
is: ENSRNOG00000019484.3
name: glycine reversible transport via sodium and chloride symport (2:1:1)
product: 415308
product: 415320

415284
type: SpeciesReference
stoichiometry: 1.0
species: 317883

317883
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Glycine_C2H5NO2

303787
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

415333
type: SpeciesReference
stoichiometry: 2.0
species: 324616

324616
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sodium_Na

415296
type: SpeciesReference
stoichiometry: 1.0
species: 311448

311448
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Chloride_Cl

415272
type: SpeciesReference
stoichiometry: 2.0
species: 324628

324628
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Sodium_Na

415308
type: SpeciesReference
stoichiometry: 1.0
species: 317871

317871
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glycine_C2H5NO2

415320
type: SpeciesReference
stoichiometry: 1.0
species: 311436

311436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Chloride_Cl

314778
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Desmosterol_C27H44O

315997
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Folate_C19H18N7O6

315130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Erythrose 4-phosphate_C4H7O7P

329824
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetracosapentaenoyl carnitine_C31H51NO4

331731
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _7alpha-Hydroxycholest-4-en-3-one_C27H44O2

310588
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Butyrate (n-C4:0)_C4H7O2

303823
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

305387
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _3-Oxodecanoyl-CoA_C31H48N7O18P3S

303847
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

967808
type: Reaction
product: 341248
product: 341212
reactant: 341175
product: 341224
notes: R_RDH2a subsystem: Vitamin A Metabolism R_RDH2a equation: [c] : nadp + retinol-9-cis <==> h + nadph + retinal-cis-9 R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal
reversible: true
fast: false
reactant: 341199
is: ENSRNOG00000025767.3
product: 341236
is: http://identifiers.org/ec-code/1.1.1.105
reactant: 341187

341248
type: SpeciesReference
stoichiometry: 2.0
species: 324869

324869
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3

341212
type: SpeciesReference
stoichiometry: 1.0
species: 328254

328254
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Retinal_C20H28O

341175
type: SpeciesReference
stoichiometry: 2.0
species: 324797

324797
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3

341224
type: SpeciesReference
stoichiometry: 1.0
species: 328241

328241
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cis-9-retinal_C20H28O

341199
type: SpeciesReference
stoichiometry: 1.0
species: 328303

328303
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Retinol_C20H30O

341236
type: SpeciesReference
stoichiometry: 2.0
species: 318954

318954
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: H+_H

341187
type: SpeciesReference
stoichiometry: 1.0
species: 328267

328267
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _9-cis-retinol_C20H30O

967555
type: Reaction
product: 338784
fast: false
product: 338796
reactant: 338772
is: http://identifiers.org/ec-code/3.2.1.23
reversible: false
name: b-galactosidase, extracellular
reactant: 338760
is: ENSRNOG00000003681.4
notes: R_LACZe subsystem: Galactose metabolism R_LACZe equation: [e] : h2o + lcts --> gal + glc-D

338784
type: SpeciesReference
stoichiometry: 1.0
species: 316829

316829
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Galactose_C6H12O6

338796
type: SpeciesReference
stoichiometry: 1.0
species: 317519

317519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Glucose_C6H12O6

338772
type: SpeciesReference
stoichiometry: 1.0
species: 318858

318858
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: H2O_H2O

338760
type: SpeciesReference
stoichiometry: 1.0
species: 322435

322435
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Lactose_C12H22O11

307331
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: R total 3 Coenzyme A_CO2FULLR3C21H31N7O15P3S

971144
type: Reaction
product: 370922
notes: R_HMGCOASim subsystem: Cholesterol Metabolism R_HMGCOASim equation: [m] : aacoa + accoa + h2o --> coa + h + hmgcoa
name: Hydroxymethylglutaryl CoA synthase (ir)
fast: false
is: ENSRNOG00000019120.4
reactant: 370873
product: 370910
reactant: 370861
is: http://identifiers.org/ec-code/4.1.3.5
reversible: false
reactant: 370885
product: 370897

370922
type: SpeciesReference
stoichiometry: 1.0
species: 319002

319002
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: H+_H

370873
type: SpeciesReference
stoichiometry: 1.0
species: 307620

307620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Acetoacetyl-CoA_C25H36N7O18P3S

370910
type: SpeciesReference
stoichiometry: 1.0
species: 319518

319518
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

370861
type: SpeciesReference
stoichiometry: 1.0
species: 318894

318894
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: H2O_H2O

370885
type: SpeciesReference
stoichiometry: 1.0
species: 307849

307849
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Acetyl-CoA_C23H34N7O17P3S

370897
type: SpeciesReference
stoichiometry: 1.0
species: 311797

311797
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Coenzyme A_C21H32N7O16P3S

318234
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: GMP_C10H12N5O8P

319806
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 1_C79H115N5O99S11

303811
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

311558
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CMP_C9H12N3O8P

306799
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: hexaglutamyl folate (THF)_C44H51N12O21

318306
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GlcNAc-alpha-1,4-Core 2_C30H50N3O20X

303799
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

323738
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Mannose 6-phosphate_C6H11O9P

329402
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Succinic semialdehyde_C4H5O3

976355
type: Reaction
product: 421114
reversible: false
reactant: 421066
product: 421138
product: 421126
reactant: 421090
notes: R_H2MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H2MTer_U equation: [r] : (0.1) dolmanp_U + mgacpail_hs --> (0.1) dolp_U + h + m2gacpail_hs R_H5MTer_U subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H5MTer_U equation: [r] : (0.1) dolmanp_U + emgacpail_hs --> (0.1) dolp_U + h + memgacpail_hs R_H2MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H2MTer_L equation: [r] : (0.1) dolmanp_L + mgacpail_hs --> (0.1) dolp_L + h + m2gacpail_hs R_H5MTer_L subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H5MTer_L equation: [r] : (0.1) dolmanp_L + emgacpail_hs --> (0.1) dolp_L + h + memgacpail_hs
reactant: 421078
reactant: 421102
fast: false
is: ENSRNOG00000000121.3
product: 421163
product: 421151

421114
type: SpeciesReference
stoichiometry: 1.0
species: 314645

314645
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dolichol phosphate, human liver homolog_C1080H1758O40P10

421066
type: SpeciesReference
stoichiometry: 1.0
species: 314620

314620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dolichyl phosphate D-mannose, human uterine homolog_C1085H1780O90P10

421138
type: SpeciesReference
stoichiometry: 2.0
species: 323167

323167
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: dimannosyl-glucosaminyl-acylphosphatidylinositol (H3)_C43H78NO24PFULLRCO2FULLR2CO2

421126
type: SpeciesReference
stoichiometry: 2.0
species: 323866

323866
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (mannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (B)_C45H84N2O27P2FULLRCO2FULLR2CO2

421090
type: SpeciesReference
stoichiometry: 1.0
species: 314596

314596
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dolichyl phosphate D-mannose, human liver homolog_C1140H1868O90P10

421078
type: SpeciesReference
stoichiometry: 2.0
species: 324059

324059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: mannosyl-glucosaminyl-acylphosphatidylinositiol (H2)_C37H68NO19PFULLRCO2FULLR2CO2

421102
type: SpeciesReference
stoichiometry: 2.0
species: 315360

315360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphoethanolaminyl-mannosyl-glucosylaminyl-acylphosphatidylinositol (H5)_C39H74N2O22P2FULLRCO2FULLR2CO2

421163
type: SpeciesReference
stoichiometry: 4.0
species: 319026

319026
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: H+_H

421151
type: SpeciesReference
stoichiometry: 1.0
species: 314669

314669
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dolichol phosphate, human uterine homolog_C1025H1670O40P10

312363
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate C (GalNAc6S-GlcA) and D (GlcNAc6S-GlcA2S), precursor 1_C31H47NO31S2X

975215
type: Reaction
product: 411783
product: 411820
product: 411808
product: 411795
reactant: 411758
notes: R_GLNtN1 subsystem: Transport, Extracellular R_GLNtN1 equation: gln-L[e] + h[c] + (2) na1[e] <==> gln-L[c] + h[e] + (2) na1[c] R_SERtN1 subsystem: Transport, Extracellular R_SERtN1 equation: h[c] + (2) na1[e] + ser-L[e] <==> h[e] + (2) na1[c] + ser-L[c] R_ASNtN1 subsystem: Transport, Extracellular R_ASNtN1 equation: asn-L[e] + h[c] + (2) na1[e] <==> asn-L[c] + h[e] + (2) na1[c] R_ALAtN1 subsystem: Transport, Extracellular R_ALAtN1 equation: ala-L[e] + h[c] + (2) na1[e] <==> ala-L[c] + h[e] + (2) na1[c]
is: ENSRNOG00000027767.2
reactant: 411746
fast: false
reactant: 411734
product: 411844
reactant: 411710
reactant: 411722
product: 411832
reversible: true
reactant: 411771

411783
type: SpeciesReference
stoichiometry: 4.0
species: 318966

318966
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: H+_H

411820
type: SpeciesReference
stoichiometry: 8.0
species: 324616

411808
type: SpeciesReference
stoichiometry: 1.0
species: 317617

317617
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Glutamine_C5H10N2O3

411795
type: SpeciesReference
stoichiometry: 1.0
species: 328773

328773
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Serine_C3H7NO3

411758
type: SpeciesReference
stoichiometry: 1.0
species: 328785

328785
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Serine_C3H7NO3

411746
type: SpeciesReference
stoichiometry: 1.0
species: 317630

317630
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Glutamine_C5H10N2O3

411734
type: SpeciesReference
stoichiometry: 8.0
species: 324628

411844
type: SpeciesReference
stoichiometry: 1.0
species: 309251

309251
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Alanine_C3H7NO2

411710
type: SpeciesReference
stoichiometry: 1.0
species: 309263

309263
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Alanine_C3H7NO2

411722
type: SpeciesReference
stoichiometry: 1.0
species: 310046

310046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Asparagine_C4H8N2O3

411832
type: SpeciesReference
stoichiometry: 1.0
species: 310033

310033
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Asparagine_C4H8N2O3

411771
type: SpeciesReference
stoichiometry: 4.0
species: 318954

323600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Malate_C4H4O5

330718
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: tetradecanoyl carnitine_C21H41NO4

327639
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Prostaglandin D2_C20H31O5

976271
type: Reaction
reactant: 420490
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
notes: R_M1316Mg subsystem: N-Glycan Biosynthesis R_M1316Mg equation: [g] : (2) h2o + nm4masn --> (2) man + nm2masn
is: ENSRNOG00000015439.4
product: 420514
reversible: false
is: ENSRNOG00000012055.4
product: 420502
fast: false
reactant: 420478
is: http://identifiers.org/ec-code/3.2.1.114

420490
type: SpeciesReference
stoichiometry: 1.0
species: 325137

325137
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C54H90N3O40X

420514
type: SpeciesReference
stoichiometry: 2.0
species: 323777

323777
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: D-Mannose_C6H12O6

420502
type: SpeciesReference
stoichiometry: 1.0
species: 325125

325125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (N-acetyl-D-glucosaminyl-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C42H70N3O30X

420478
type: SpeciesReference
stoichiometry: 2.0
species: 318870

318870
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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name: dUDP_C9H11N2O11P2

974350
type: Reaction
reactant: 404307
reactant: 404222
reactant: 404367
reactant: 404066
reactant: 404005
product: 404416
reactant: 403981
reactant: 404379
reactant: 404150
product: 404645
product: 404609
is: http://identifiers.org/ec-code/2.3.1.21
fast: false
product: 404693
product: 404753
product: 404464
reactant: 404319
reactant: 404234
reactant: 404078
reactant: 404017
reactant: 404246
product: 404717
is: http://identifiers.org/ec-code/4.2.1.1
reactant: 403993
reactant: 404162
reactant: 404029
product: 404512
reactant: 404174
product: 404560
product: 404777
product: 404585
product: 404488
reactant: 404258
is: ENSRNOG00000002916.4
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reactant: 404186
product: 404633
product: 404548
product: 404536
product: 404440
modifier: 404801
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reactant: 404198
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notes: R_LGNCCPT1 subsystem: Carnitine shuttle R_LGNCCPT1 equation: [c] : crn + lgnccoa --> coa + lgnccrn R_TETPENT3CPT1 subsystem: Carnitine shuttle R_TETPENT3CPT1 equation: [c] : crn + tetpent3coa --> coa + tetpent3crn R_ELAIDCPT1 subsystem: Carnitine shuttle R_ELAIDCPT1 equation: [c] : crn + od2coa --> coa + elaidcrn R_ADRNCPT1 subsystem: Carnitine shuttle R_ADRNCPT1 equation: [c] : adrncoa + crn --> adrncrn + coa R_DCSPTN1CPT1 subsystem: Carnitine shuttle R_DCSPTN1CPT1 equation: [c] : crn + dcsptn1coa --> coa + dcsptn1crn R_C204CPT1 subsystem: Carnitine shuttle R_C204CPT1 equation: [c] : arachdcoa + crn --> arachdcrn + coa R_DLNLCGCPT1 subsystem: Carnitine shuttle R_DLNLCGCPT1 equation: [c] : crn + dlnlcgcoa --> coa + dlnlcgcrn R_TMNDNCCPT1 subsystem: Carnitine shuttle R_TMNDNCCPT1 equation: [c] : crn + tmndnccoa --> coa + tmndnccrn R_C180CPT1 subsystem: Carnitine shuttle R_C180CPT1 equation: [c] : crn + stcoa --> coa + stcrn R_LNLNCGCPT1 subsystem: Carnitine shuttle R_LNLNCGCPT1 equation: [c] : crn + lnlncgcoa --> coa + lnlncgcrn R_TTDCPT1 subsystem: Carnitine shuttle R_TTDCPT1 equation: [c] : crn + tdcoa --> coa + ttdcrn R_NRVNCCPT1 subsystem: Carnitine shuttle R_NRVNCCPT1 equation: [c] : crn + nrvnccoa --> coa + nrvnccrn R_LNLNCACPT1 subsystem: Carnitine shuttle R_LNLNCACPT1 equation: [c] : crn + lnlncacoa --> coa + lnlncacrn R_VACCCPT1 subsystem: Carnitine shuttle R_VACCCPT1 equation: [c] : crn + vacccoa --> coa + vacccrn R_PTDCACRNCPT1 subsystem: Carnitine shuttle R_PTDCACRNCPT1 equation: [c] : crn + ptdcacoa --> coa + ptdcacrn R_CLPNDCPT1 subsystem: Carnitine shuttle R_CLPNDCPT1 equation: [c] : clpndcoa + crn --> clpndcrn + coa R_EICOSTETCPT1 subsystem: Carnitine shuttle R_EICOSTETCPT1 equation: [c] : crn + eicostetcoa --> coa + eicostetcrn R_C160CPT1 subsystem: Carnitine shuttle R_C160CPT1 equation: [c] : crn + pmtcoa --> coa + pmtcrn R_RTOTAL3CRNCPT1 subsystem: Carnitine shuttle R_RTOTAL3CRNCPT1 equation: [c] : Rtotal3coa + crn --> Rtotal3crn + coa R_LNLCCPT1 s…
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product: 404476
reactant: 404090
reactant: 404343
reactant: 404294
product: 404729
reactant: 404126
reactant: 404355
product: 404621
product: 404524
reactant: 404138
product: 404741
product: 404705
product: 404572
reversible: false
product: 404789
product: 404597
reactant: 404210
reactant: 404054

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307415
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name: R total Coenzyme A_CO2FULLRC21H31N7O15P3S

404222
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species: 326987

326987
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species: 322951

322951
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name: gamma-linolenoyl-CoA_C39H60N7O17P3S

404066
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310613
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404005
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309888
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404416
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311759
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313352
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319278
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404150
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species: 329788

329788
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311521
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404609
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species: 315251

315251
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initial amount: NaN
in compartment: 303763
name: Eicosatetranoyl carnitine_C27H45NO4

404693
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307343
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404753
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319410
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404464
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325816
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404319
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322639
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309792
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404078
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307247
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initial concentration: NaN
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name: R total 2 coenzyme A_CO2FULLR2C21H31N7O15P3S

404017
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species: 329715

329715
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name: tetracosapentaenoyl coenzyme A, n-3_C45H68N7O17P3S

404246
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species: 329160

329160
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initial concentration: NaN
initial amount: NaN
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name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S

404717
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species: 325344

325344
type: Species
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nervonyl carnitine_C31H59NO4

403993
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species: 307319

307319
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total 3 Coenzyme A_CO2FULLR3C21H31N7O15P3S

404162
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species: 322891

322891
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-Linolenoyl-CoA_C39H60N7O17P3S

404029
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species: 325307

325307
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: nervonyl coenzyme A_C45H76N7O17P3S

404512
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species: 307451

307451
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total carnitine_CO2FULLRC7H14NO2

404174
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species: 312050

312050
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Carnitine_C7H15NO3

404560
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species: 330381

330381
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Timnodonyl carnitine_C27H43NO4

404777
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species: 329896

329896
type: Species
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tetracosatetraenoyl carnitine_C31H53NO4

404585
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species: 327917

327917
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pendtadenoyl carnitine_C22H43NO4

404488
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species: 308837

308837
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adrenyl carnitine_C29H49NO4

404258
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species: 327893

327893
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initial amount: NaN
in compartment: 303763
name: pentadecanoyl Coenzyme A_C36H60N7O17P3S

404041
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325779
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initial concentration: NaN
initial amount: NaN
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name: Octadecenoyl-CoA (n-C18:1CoA)_C39H64N7O17P3S

404186
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species: 308801

308801
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initial concentration: NaN
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in compartment: 303763
name: adrenyl coenzyme A_C43H66N7O17P3S

404633
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species: 307271

307271
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initial concentration: NaN
initial amount: NaN
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name: R total 2 carnitine_CO2FULLR2C7H14NO2

404548
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species: 330706

330706
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetradecanoyl carnitine_C21H41NO4

404536
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species: 322915

322915
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-linolenyl carnitine_C25H43NO4

404440
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species: 314307

314307
type: Species
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initial concentration: NaN
initial amount: NaN
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name: dihomo-gamma-linolenyl carnitine_C27H47NO4

318750
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name: carbonic acid_H2CO3

404681
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329752
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404198
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325755
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404452
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species: 319230

319230
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in compartment: 303763
name: Hexadecenoyl carnitine_C23H43NO4

311681
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name: CO2_CO2

404270
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331393
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318846
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404403
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322675
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404102
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314283
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404331
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319614
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name: heptadecanoyl coa_C38H64N7O17P3S

404282
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311484
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name: clupanodonyl CoA_C43H64N7O17P3S

404500
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species: 309924

309924
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name: C20:4 carnitine_C27H45NO4

404428
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species: 329824

404114
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species: 322831

322831
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name: linoleic coenzyme A_C39H62N7O17P3S

404669
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313389
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initial concentration: NaN
initial amount: NaN
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name: docosa-4,7,10,13,16-pentaenoyl carnitine_C29H47NO4

404657
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species: 309828

309828
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: arachidyl carnitine_C27H53NO4

404391
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species: 322987

322987
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initial concentration: NaN
initial amount: NaN
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name: gamma-linolenyl carnitine_C25H43NO4

404765
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species: 322855

322855
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initial concentration: NaN
initial amount: NaN
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name: Linoleyl carnitine_C25H45NO4

404476
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species: 319314

319314
type: Species
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: trans-Hexadec-2-enoyl carnitine_C23H43NO4

404090
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species: 319254

319254
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hexadecenoyl-CoA (n-C16:1CoA)_C37H60N7O17P3S

404343
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species: 322771

322771
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: linoelaidyl coenzyme A_C39H62N7O17P3S

404294
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species: 330344

330344
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: timnodonyl coenzyme A_C41H60N7O17P3S

404729
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species: 322795

322795
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Linoelaidyl carnitine_C25H45NO4

404126
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species: 329616

329616
type: Species
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has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tetradecanoyl-CoA (n-C14:0CoA)_C35H58N7O17P3S

404355
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species: 329860

329860
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S

404621
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species: 329196

329196
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: stearoylcarnitine_C25H49NO4

404524
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species: 327023

327023
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Palmitoylcarnitine_C23H45NO4

404138
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species: 315227

315227
type: Species
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: eicosatetranoyl coenzyme A_C41H62N7O17P3S

404741
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species: 329293

329293
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: stearidonyl carnitine_C25H41NO4

404705
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species: 331417

331417
type: Species
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Vaccenyl carnitine_C25H47NO4

404572
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species: 310649

310649
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name: cervonyl carnitine_C29H45NO4

404789
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species: 319638

319638
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initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: heptadecanoyl carnitine_C24H47NO4

404597
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315287
type: Species
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initial concentration: NaN
initial amount: NaN
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name: Elaidic carnitine_C25H47NO4

404210
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species: 319374

319374
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
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name: Hexacosanoyl-CoA (n-C26:0CoA)_C47H82N7O17P3S

404054
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species: 329257

329257
type: Species
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boundary condition: false
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initial amount: NaN
in compartment: 303763
name: stearidonyl coenzyme A_C39H58N7O17P3S

305146
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boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Hydroxypropionyl-CoA_C24H36N7O18P3S

969131
type: Reaction
notes: R_3HCO3_NAt subsystem: Transport, Extracellular R_3HCO3_NAt equation: (3) hco3[e] + na1[e] <==> (3) hco3[c] + na1[c] R_2HCO3_NAt subsystem: Transport, Extracellular R_2HCO3_NAt equation: (2) hco3[e] + na1[e] <==> (2) hco3[c] + na1[c]
fast: false
reversible: true
reactant: 353566
product: 353602
product: 353590
is: ENSRNOG00000010378.4
is: ENSRNOG00000003134.2
reactant: 353578

353566
type: SpeciesReference
stoichiometry: 2.0
species: 324628

353602
type: SpeciesReference
stoichiometry: 2.0
species: 324616

353590
type: SpeciesReference
stoichiometry: 5.0
species: 319110

319110
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Bicarbonate_CHO3

353578
type: SpeciesReference
stoichiometry: 5.0
species: 319122

319122
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Bicarbonate_CHO3

325767
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

331694
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3alpha,7alpha,26-Trihydroxy-5beta-cholestane_C27H48O3

315214
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: eicosatetranoic acid_C20H31O2

307536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: trans-4-Hydroxycinnamate_C9H7O3

328857
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-sulfolactate_C3H4O6S

968565
type: Reaction
notes: R_S3T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T1g equation: [g] : hs_pre13 + paps --> h + hs_pre14 + pap
is: ENSRNOG00000021441.3
reactant: 348331
reactant: 348319
product: 348343
is: http://identifiers.org/ec-code/2.8.2.23
reversible: false
product: 348356
product: 348368
fast: false
name: heparin-glucosamine 3-O-sulfotransferase

348331
type: SpeciesReference
stoichiometry: 1.0
species: 320040

320040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 13_C79H116N5O92S9X

348319
type: SpeciesReference
stoichiometry: 1.0
species: 326385

326385
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: _3'-Phosphoadenylyl sulfate_C10H11N5O13P2S

348343
type: SpeciesReference
stoichiometry: 1.0
species: 318978

318978
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: H+_H

348356
type: SpeciesReference
stoichiometry: 1.0
species: 320052

320052
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 14_C79H115N5O95S10X

348368
type: SpeciesReference
stoichiometry: 1.0
species: 326361

326361
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Adenosine 3',5'-bisphosphate_C10H11N5O10P2

326119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)_C9H13O18P4FULLRCO2FULLR2CO2

303835
type: Compartment
constant: true
size: NaN
spatial dimensions: 3.0

318088
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: glycogen, structure 1 (glycogenin-11[1,4-Glc])_C66H111O56X

315022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deoxyuridine_C9H12N2O5

969951
type: Reaction
fast: false
product: 360183
product: 360171
reversible: false
notes: R_EBP2r subsystem: Cholesterol Metabolism R_EBP2r equation: [r] : zymstnl --> lthstrl R_EBP1r subsystem: Cholesterol Metabolism R_EBP1r equation: [r] : zymst --> chlstol
is: http://identifiers.org/ec-code/5.3.3.5
is: ENSRNOG00000004903.4
reactant: 360159
reactant: 360147

360183
type: SpeciesReference
stoichiometry: 1.0
species: 311024

311024
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Cholesta-7,24-dien-3beta-ol_C27H44O

360171
type: SpeciesReference
stoichiometry: 1.0
species: 323059

323059
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _5alpha-Cholest-7-en-3beta-ol_C27H46O

360159
type: SpeciesReference
stoichiometry: 1.0
species: 332046

332046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Zymostenol_C27H46O

360147
type: SpeciesReference
stoichiometry: 1.0
species: 332034

332034
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: zymosterol_C27H44O

326903
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Phosphate_HO4P

972525
type: Reaction
product: 385450
reversible: false
is: http://identifiers.org/ec-code/1.1.1.102
product: 385462
notes: R_3DSPHR subsystem: Sphingolipid Metabolism R_3DSPHR equation: [c] : 3dsphgn + h + nadph --> nadp + sphgn
name: _3-Dehydrosphinganine reductase
reactant: 385426
reactant: 385438
fast: false
reactant: 385414
is: ENSRNOG00000002781.4

385450
type: SpeciesReference
stoichiometry: 1.0
species: 328977

328977
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sphinganine_C18H40NO2

385462
type: SpeciesReference
stoichiometry: 1.0
species: 324797

385426
type: SpeciesReference
stoichiometry: 1.0
species: 318954

385438
type: SpeciesReference
stoichiometry: 1.0
species: 324869

385414
type: SpeciesReference
stoichiometry: 1.0
species: 305025

305025
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Dehydrosphinganine_C18H38NO2

330174
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _2,3,4,5-Tetrahydropyridine-2-carboxylate_C6H8NO2

331272
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Uridine_C9H12N2O6

967447
type: Reaction
notes: R_CEPTC subsystem: Glycerophospholipid Metabolism R_CEPTC equation: [c] : cdpchol + dag_hs --> cmp + h + pchol_hs
is: ENSRNOG00000005487.3
name: choline phosphotransferase
reactant: 337882
product: 337906
reactant: 337869
reversible: false
product: 337894
product: 337918
fast: false

337882
type: SpeciesReference
stoichiometry: 1.0
species: 310927

310927
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CDPcholine_C14H25N4O11P2

337906
type: SpeciesReference
stoichiometry: 1.0
species: 326397

326397
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2

337869
type: SpeciesReference
stoichiometry: 1.0
species: 313110

313110
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: diacylglycerol (homo sapiens)_C3H6OFULLRCO2FULLR2CO2

337894
type: SpeciesReference
stoichiometry: 1.0
species: 311558

337918
type: SpeciesReference
stoichiometry: 1.0
species: 318954

977423
type: Reaction
modifier: 433438
modifier: 433364
modifier: 433351
fast: false
modifier: 433413
reversible: false
modifier: 433339
notes: R_ADNt subsystem: Transport, Extracellular R_ADNt equation: adn[e] <==> adn[c] R_ADNtm subsystem: Transport, Mitochondrial R_ADNtm equation: adn[c] <==> adn[m] R_INSt subsystem: Transport, Extracellular R_INSt equation: ins[e] <==> ins[c] R_URIt subsystem: Transport, Extracellular R_URIt equation: uri[e] <==> uri[c] R_GSNt subsystem: Transport, Extracellular R_GSNt equation: gsn[e] <==> gsn[c] R_GSNtm subsystem: Transport, Mitochondrial R_GSNtm equation: gsn[c] <==> gsn[m] R_Uritm subsystem: Transport, Mitochondrial R_Uritm equation: uri[c] <==> uri[m] R_CYTDtm subsystem: Transport, Mitochondrial R_CYTDtm equation: cytd[c] <==> cytd[m] R_INStm subsystem: Transport, Mitochondrial R_INStm equation: ins[c] <==> ins[m] R_THYMDtm subsystem: Transport, Mitochondrial R_THYMDtm equation: thymd[c] <==> thymd[m] R_THYMDt1 subsystem: Transport, Extracellular R_THYMDt1 equation: thymd[e] --> thymd[c] R_CYTDt subsystem: Transport, Extracellular R_CYTDt equation: cytd[e] <==> cytd[c]
product: 433302
modifier: 433510
modifier: 433327
modifier: 433486
modifier: 433389
modifier: 433376
modifier: 433425
modifier: 433450
reactant: 433290
modifier: 433498
modifier: 433401
modifier: 433474
modifier: 433462
is: ENSRNOG00000019752.3
modifier: 433315

318486
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Guanosine_C10H13N5O5

330234
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Thymidine_C10H14N2O5

312978
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Cytidine_C9H13N3O5

308597
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Adenosine_C10H13N5O4

331308
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Uridine_C9H12N2O6

433302
type: SpeciesReference
stoichiometry: 1.0
species: 330234

320620
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Inosine_C10H12N4O5

313014
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Cytidine_C9H13N3O5

308573
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Adenosine_C10H13N5O4

320644
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Inosine_C10H12N4O5

331284
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Uridine_C9H12N2O6

308561
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adenosine_C10H13N5O4

320608
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Inosine_C10H12N4O5

433290
type: SpeciesReference
stoichiometry: 1.0
species: 330246

330246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Thymidine_C10H14N2O5

318462
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Guanosine_C10H13N5O5

318450
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Guanosine_C10H13N5O5

312990
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Cytidine_C9H13N3O5

330270
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Thymidine_C10H14N2O5

976283
type: Reaction
product: 420538
reactant: 420526
notes: R_ACONTm subsystem: Citric Acid Cycle R_ACONTm equation: [m] : cit <==> icit
is: ENSRNOG00000024128.2
is: http://identifiers.org/ec-code/4.2.1.3
fast: false
reversible: true
name: Aconitate hydratase

420538
type: SpeciesReference
stoichiometry: 1.0
species: 320332

320332
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Isocitrate_C6H5O7

420526
type: SpeciesReference
stoichiometry: 1.0
species: 311400

311400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Citrate_C6H5O7

305629
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4,6-Dihydroxyquinoline_C9H7NO2

304052
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _11-Deoxycortisol_C21H30O4

326711
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidyl glycerol phosphate (homo sapiens)_C6H11O9P2FULLRCO2FULLR2CO2

309359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: S-aminomethyldihydrolipoamide_C9H21N2OS2

323588
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Malate_C4H4O5

309936
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: C20:4 carnitine_C27H45NO4

310070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Aspartate_C4H6NO4

305109
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

971096
type: Reaction
reversible: false
reactant: 370607
product: 370631
notes: R_HSD17B3r subsystem: Steroid Metabolism R_HSD17B3r equation: [r] : andrstndn + h + nadph --> nadp + tststerone
reactant: 370619
fast: false
reactant: 370595
is: ENSRNOG00000019096.2
product: 370644
name: testicular 17-beta-hydroxysteroid dehydrogenase
is: http://identifiers.org/ec-code/1.1.1.62

370607
type: SpeciesReference
stoichiometry: 1.0
species: 309552

309552
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Androstenedione_C19H26O2

370631
type: SpeciesReference
stoichiometry: 1.0
species: 330574

330574
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Testosterone_C19H28O2

370619
type: SpeciesReference
stoichiometry: 1.0
species: 319026

370595
type: SpeciesReference
stoichiometry: 1.0
species: 324905

324905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3

370644
type: SpeciesReference
stoichiometry: 1.0
species: 324845

324845
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3

327194
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Diphosphate_HO7P2

331755
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _7alpha,12alpha-Dihydroxycholest-4-en-3-one_C27H44O3

317288
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GD1c (homo sapiens)_C66H111N4O38FULLRCO

331586
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Xanthosine 5'-phosphate_C10H11N4O9P

310721
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Carbamoyl-beta-alanine_C4H7N2O3

976523
type: Reaction
reversible: true
is: ENSRNOG00000020951.4
notes: R_HCO3_CLt subsystem: Transport, Extracellular R_HCO3_CLt equation: cl[c] + hco3[e] <==> cl[e] + hco3[c]
product: 423411
reactant: 423399
fast: false
is: ENSRNOG00000014347.3
product: 423423
reactant: 423387
is: ENSRNOG00000020138.4
name: bicarbonate transport (Cl-/HCO3- exchange)
is: ENSRNOG00000018525.4

423411
type: SpeciesReference
stoichiometry: 1.0
species: 319110

423399
type: SpeciesReference
stoichiometry: 1.0
species: 319122

423423
type: SpeciesReference
stoichiometry: 1.0
species: 311448

423387
type: SpeciesReference
stoichiometry: 1.0
species: 311436

971372
type: Reaction
product: 372642
is: http://identifiers.org/ec-code/2.7.8.11
reactant: 372618
is: ENSRNOG00000002949.4
reversible: false
fast: false
product: 372654
notes: R_PGPPT subsystem: Glycerophospholipid Metabolism R_PGPPT equation: [c] : cdpdag_hs + glyc3p --> cmp + h + pgp_hs
product: 372630
reactant: 372606
name: phosphatidyl-CMP: glycerophosphate phosphatidyltransferase

372642
type: SpeciesReference
stoichiometry: 1.0
species: 311558

372618
type: SpeciesReference
stoichiometry: 1.0
species: 310939

310939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CDP diacylglycerol (homo sapiens)_C12H17N3O11P2FULLRCO2FULLR2CO2

372654
type: SpeciesReference
stoichiometry: 1.0
species: 318954

372630
type: SpeciesReference
stoichiometry: 1.0
species: 326711

372606
type: SpeciesReference
stoichiometry: 1.0
species: 317967

317967
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glycerol 3-phosphate_C3H7O6P

327796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Propenoyl-CoA_C24H34N7O17P3S

304256
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _17alpha-Hydroxyprogesterone_C21H30O3

974951
type: Reaction
product: 409409
fast: false
reactant: 409349
product: 409433
is: http://identifiers.org/ec-code/3.6.1.19
reactant: 409373
reactant: 409361
notes: R_NTPP11 subsystem: Nucleotides R_NTPP11 equation: [c] : h2o + xtp --> h + ppi + xmp R_NTPP10 subsystem: Nucleotides R_NTPP10 equation: [c] : ditp + h2o --> dimp + h + ppi R_NTPP9 subsystem: Nucleotides R_NTPP9 equation: [c] : h2o + itp --> h + imp + ppi
product: 409421
product: 409397
reactant: 409385
is: ENSRNOG00000021233.4
product: 409445
reversible: false

409409
type: SpeciesReference
stoichiometry: 1.0
species: 314199

314199
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dIMP_C10H11N4O7P

409349
type: SpeciesReference
stoichiometry: 1.0
species: 331914

331914
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: XTP_C10H11N4O15P3

409433
type: SpeciesReference
stoichiometry: 3.0
species: 318954

409373
type: SpeciesReference
stoichiometry: 3.0
species: 318846

409361
type: SpeciesReference
stoichiometry: 1.0
species: 314235

314235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dITP_C10H11N4O13P3

409421
type: SpeciesReference
stoichiometry: 1.0
species: 320536

320536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: IMP_C10H11N4O8P

409397
type: SpeciesReference
stoichiometry: 1.0
species: 331586

409385
type: SpeciesReference
stoichiometry: 1.0
species: 320716

320716
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: ITP_C10H11N4O14P3

409445
type: SpeciesReference
stoichiometry: 3.0
species: 327157

327157
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Diphosphate_HO7P2

968951
type: Reaction
reversible: false
reactant: 351902
product: 351926
notes: R_GF6PTA subsystem: Aminosugar Metabolism R_GF6PTA equation: [c] : f6p + gln-L --> gam6p + glu-L
reactant: 351890
is: ENSRNOG00000002810.4
product: 351914
is: ENSRNOG00000018507.4
name: glutamine-fructose-6-phosphate transaminase
is: http://identifiers.org/ec-code/2.6.1.16
fast: false

351902
type: SpeciesReference
stoichiometry: 1.0
species: 315708

315708
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Fructose 6-phosphate_C6H11O9P

351926
type: SpeciesReference
stoichiometry: 1.0
species: 317683

317683
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Glutamate_C5H8NO4

351890
type: SpeciesReference
stoichiometry: 1.0
species: 317617

351914
type: SpeciesReference
stoichiometry: 1.0
species: 317107

317107
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glucosamine 6-phosphate_C6H13NO8P

324737
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2

331514
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: omega hydroxy dodecanoate (n-C12:0)_C12H23O3

976583
type: Reaction
is: http://identifiers.org/ec-code/3.5.3.1
fast: false
product: 423676
reversible: false
is: ENSRNOG00000013304.3
name: arginase
reactant: 423652
product: 423664
notes: R_ARGN subsystem: Urea cycle/amino group metabolism R_ARGN equation: [c] : arg-L + h2o --> orn + urea
reactant: 423640

423676
type: SpeciesReference
stoichiometry: 1.0
species: 331235

331235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Urea_CH4N2O

423652
type: SpeciesReference
stoichiometry: 1.0
species: 318846

423664
type: SpeciesReference
stoichiometry: 1.0
species: 325902

325902
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Ornithine_C5H13N2O2

423640
type: SpeciesReference
stoichiometry: 1.0
species: 309961

309961
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Arginine_C6H15N4O2

966918
type: Reaction
reactant: 333165
notes: R_BAAT1x subsystem: Bile Acid Biosynthesis R_BAAT1x equation: [x] : cholcoa + gly --> coa + gchola R_BAAT4x subsystem: Bile Acid Biosynthesis R_BAAT4x equation: [x] : dcholcoa + gly --> coa + gdchola R_BAAT2x subsystem: Bile Acid Biosynthesis R_BAAT2x equation: [x] : cholcoa + taur --> coa + tchola R_BAAT3x subsystem: Bile Acid Biosynthesis R_BAAT3x equation: [x] : dgcholcoa + gly --> coa + dgchol R_BAAT5x subsystem: Bile Acid Biosynthesis R_BAAT5x equation: [x] : dcholcoa + taur --> coa + tdchola
is: ENSRNOG00000039151.1
reactant: 333153
reactant: 333201
is: ENSRNOG00000007395.3
product: 333249
is: http://identifiers.org/ec-code/2.3.1.65
reversible: false
product: 333237
reactant: 333177
product: 333273
is: ENSRNOG00000039153.1
product: 333225
reactant: 333189
fast: false
product: 333261
product: 333213

333165
type: SpeciesReference
stoichiometry: 1.0
species: 313631

313631
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847

333153
type: SpeciesReference
stoichiometry: 2.0
species: 311133

311133
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Choloyl-CoA_C45H70N7O20P3S

333201
type: SpeciesReference
stoichiometry: 2.0
species: 313291

313291
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: chenodeoxycholoyl coenzyme a_C45H70N7O19P3S

333249
type: SpeciesReference
stoichiometry: 1.0
species: 329603

329603
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: taurochenodeoxycholate_C26H45NO6S

333237
type: SpeciesReference
stoichiometry: 1.0
species: 317228

317228
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: glycocholate_C26H43NO6

333177
type: SpeciesReference
stoichiometry: 3.0
species: 317919

317919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Glycine_C2H5NO2

333273
type: SpeciesReference
stoichiometry: 1.0
species: 313619

313619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Chenodeoxyglycocholate_C26H43NO5

333225
type: SpeciesReference
stoichiometry: 5.0
species: 311833

311833
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Coenzyme A_C21H32N7O16P3S

333189
type: SpeciesReference
stoichiometry: 2.0
species: 329510

329510
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Taurine_C2H7NO3S

333261
type: SpeciesReference
stoichiometry: 1.0
species: 317336

317336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: glycochenodeoxycholate_C26H43NO5

333213
type: SpeciesReference
stoichiometry: 1.0
species: 329564

329564
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: taurocholic acid_C26H45NO7S

321489
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 20_C171H274N12O140S6X

329329
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Succinate_C4H4O4

328881
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Sulfite_O3S

326699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: phosphatidylglycerol (homo sapiens)_C6H12O6PFULLRCO2FULLR2CO2

305728
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Aminobutanal_C4H10NO

975443
type: Reaction
reversible: false
product: 414116
reactant: 414020
product: 414092
reactant: 414068
reactant: 414056
reactant: 413984
is: ENSRNOG00000015478.4
product: 414140
product: 414128
reactant: 414044
reactant: 414032
reactant: 414008
is: http://identifiers.org/ec-code/3.5.4.5
product: 414104
product: 414080
is: http://identifiers.org/ec-code/3.5.4.14
fast: false
reactant: 413996
notes: R_DCYTD subsystem: Pyrimidine Catabolism R_DCYTD equation: [c] : dcyt + h + h2o --> duri + nh4 R_CYTDn subsystem: Nucleotides R_CYTDn equation: [n] : cytd + h + h2o --> nh4 + uri R_DCYTDn subsystem: Nucleotides R_DCYTDn equation: [n] : dcyt + h + h2o --> duri + nh4 R_CYTD subsystem: Pyrimidine Catabolism R_CYTD equation: [c] : cytd + h + h2o --> nh4 + uri

414116
type: SpeciesReference
stoichiometry: 1.0
species: 331320

331320
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Uridine_C9H12N2O6

414020
type: SpeciesReference
stoichiometry: 1.0
species: 312978

414092
type: SpeciesReference
stoichiometry: 2.0
species: 325028

325028
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Ammonium_H4N

414068
type: SpeciesReference
stoichiometry: 2.0
species: 318954

414056
type: SpeciesReference
stoichiometry: 2.0
species: 318906

318906
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: H2O_H2O

413984
type: SpeciesReference
stoichiometry: 1.0
species: 313026

313026
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Cytidine_C9H13N3O5

414140
type: SpeciesReference
stoichiometry: 1.0
species: 331272

414128
type: SpeciesReference
stoichiometry: 2.0
species: 324991

324991
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Ammonium_H4N

414044
type: SpeciesReference
stoichiometry: 2.0
species: 318846

414032
type: SpeciesReference
stoichiometry: 1.0
species: 313449

313449
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deoxycytidine_C9H13N3O4

414008
type: SpeciesReference
stoichiometry: 2.0
species: 319014

319014
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: H+_H

414104
type: SpeciesReference
stoichiometry: 1.0
species: 315046

315046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Deoxyuridine_C9H12N2O5

414080
type: SpeciesReference
stoichiometry: 1.0
species: 315022

413996
type: SpeciesReference
stoichiometry: 1.0
species: 313473

313473
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Deoxycytidine_C9H13N3O4

969443
type: Reaction
reactant: 356106
is: ENSRNOG00000027076.3
fast: false
reversible: true
is: ENSRNOG00000018822.2
is: ENSRNOG00000006786.4
notes: R_GLCt4 subsystem: Transport, Extracellular R_GLCt4 equation: glc-D[e] + na1[e] <==> glc-D[c] + na1[c]
name: glucose transport via sodium symport
is: ENSRNOG00000002616.4
is: ENSRNOG00000001298.4
is: ENSRNOG00000029979.2
is: ENSRNOG00000028008.3
product: 356130
reactant: 356118
product: 356142

356106
type: SpeciesReference
stoichiometry: 1.0
species: 324628

356130
type: SpeciesReference
stoichiometry: 1.0
species: 324616

356118
type: SpeciesReference
stoichiometry: 1.0
species: 317519

356142
type: SpeciesReference
stoichiometry: 1.0
species: 317507

317507
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glucose_C6H12O6

326252
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2

321537
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 24_C191H306N13O158S7X

308524
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Adenine_C5H5N5

304016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _10-Formyltetrahydrofolate_C20H21N7O7

311242
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Choline phosphate_C5H13NO4P

308163
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: nLc5Cer_C52H92N3O27FULLRCO

975191
type: Reaction
modifier: 411600
is: http://identifiers.org/ec-code/1.2.1.4
is: http://identifiers.org/ec-code/1.2.1.5
notes: R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHXMANDACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhmald + h2o + nadp <==> 34dhoxmand + (2) h + nadph R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD19x_LPAREN_P_RPAREN_ subsystem: Phenylalanine metabolism R_ALDD19x_LPAREN_P_RPAREN_ equation: [c] : h2o + nadp + pacald --> (2) h + nadph + pac R_34DHPLACOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_34DHPLACOX_LPAREN_NADP_RPAREN_ equation: [c] : 34dhpac + h2o + nadp <==> 34dhpha + (2) h + nadph R_3MOX4HOXPGALDOX subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX equation: [c] : 3m4hpga + h2o + nad --> 3mox4hoxm + (2) h + nadh R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_4HOXPACDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_4HOXPACDOX_LPAREN_NADP_RPAREN_ equation: [c] : 4hoxpacd + h2o + nadp <==> 4hphac + (2) h + nadph R_3M4HDXPAC subsystem: Tyrosine metabolism R_3M4HDXPAC equation: [c] : 3mox4hpac + h2o + nad <==> (2) h + homoval + nadh R_34DHPLACOX subsystem: Tyrosine metabolism R_34DHPLACOX equation: [c] : 34dhpac + h2o + nad --> 34dhpha + (2) h + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ subsystem: Tyrosine metabolism R_3MOX4HOXPGALDOX_LPAREN_NADP_RPAREN_ equation: [c] : 3m4hpga + h2o + nadp <==> 3mox4hoxm + (2) h + nadph R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_ALDD19x subsystem: Phenylalanine metabolism R_ALDD19x equation: [c] : h2o + nad + pacald --> (2) h + nadh + pac R_GCALDD subsy…
modifier: 411504
is: http://identifiers.org/ec-code/1.2.1.21
is: http://identifiers.org/ec-code/1.2.1.3
product: 411388
modifier: 411491
modifier: 411564
is: ENSRNOG00000002342.3
product: 411376
product: 411316
product: 411364
reactant: 411182
reactant: 411255
reactant: 411158
reactant: 411231
is: ENSRNOG00000017872.4
modifier: 411540
modifier: 411612
reactant: 411134
modifier: 411426
modifier: 411516
fast: false
is: ENSRNOG00000002331.4
reactant: 411170
product: 411304
reactant: 411267
modifier: 411576
product: 411328
product: 411400
reversible: false
modifier: 411452
reactant: 411194
reactant: 411206
modifier: 411465
reactant: 411219
product: 411340
modifier: 411439
is: http://identifiers.org/ec-code/1.2.1.39
modifier: 411552
modifier: 411478
reactant: 411146
is: ENSRNOG00000029789.2
product: 411413
modifier: 411528
product: 411292
product: 411280
reactant: 411243
product: 411352
modifier: 411588

324749
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2

304833
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3,4-Dihydroxyphenylacetate_C8H7O4

411388
type: SpeciesReference
stoichiometry: 1.0
species: 305351

305351
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methoxy-4-hydroxymandelate_C9H9O5

304797
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3,4-Dihydroxymandelate_C8H7O5

411376
type: SpeciesReference
stoichiometry: 23.0
species: 318954

411316
type: SpeciesReference
stoichiometry: 1.0
species: 304833

411364
type: SpeciesReference
stoichiometry: 1.0
species: 322287

322287
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Lactate_C3H5O3

411182
type: SpeciesReference
stoichiometry: 1.0
species: 304821

304821
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3,4-Dihydroxyphenylacetaldehyde_C8H8O3

411255
type: SpeciesReference
stoichiometry: 1.0
species: 317482

317482
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-glucurono-6,3-lactone_C6H8O6

411158
type: SpeciesReference
stoichiometry: 9.0
species: 324676

324676
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2

411231
type: SpeciesReference
stoichiometry: 2.0
species: 326070

326070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phenylacetaldehyde_C8H8O

305837
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Hydroxyphenylacetate_C8H7O3

411134
type: SpeciesReference
stoichiometry: 1.0
species: 305291

305291
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methylimidazole acetaldehyde_C6H8N2O

305363
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methoxy-4-hydroxyphenylacetaldehyde_C9H10O3

305243
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methoxy-4-hydroxyphenylglycolaldehyde_C9H10O4

411170
type: SpeciesReference
stoichiometry: 1.0
species: 317180

317180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glycolaldehyde_C2H4O2

411304
type: SpeciesReference
stoichiometry: 1.0
species: 317567

317567
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glucarate_C6H8O8

411267
type: SpeciesReference
stoichiometry: 1.0
species: 322361

322361
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Lactaldehyde_C3H6O2

411328
type: SpeciesReference
stoichiometry: 1.0
species: 305279

305279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methylimidazoleacetic acid_C6H7N2O2

411400
type: SpeciesReference
stoichiometry: 9.0
species: 324749

411194
type: SpeciesReference
stoichiometry: 2.0
species: 307777

307777
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetaldehyde_C2H4O

411206
type: SpeciesReference
stoichiometry: 1.0
species: 305243

305825
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Hydroxyphenylacetaldehyde_C8H8O2

411219
type: SpeciesReference
stoichiometry: 2.0
species: 324797

411340
type: SpeciesReference
stoichiometry: 2.0
species: 326058

326058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phenylacetic acid_C8H7O2

319590
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Homovanillate_C9H9O4

411146
type: SpeciesReference
stoichiometry: 1.0
species: 322386

322386
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Lactaldehyde_C3H6O2

411413
type: SpeciesReference
stoichiometry: 2.0
species: 324869

411292
type: SpeciesReference
stoichiometry: 2.0
species: 307681

307681
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetate_C2H3O2

411280
type: SpeciesReference
stoichiometry: 1.0
species: 318052

318052
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glycolate_C2H3O3

411243
type: SpeciesReference
stoichiometry: 12.0
species: 318846

411352
type: SpeciesReference
stoichiometry: 1.0
species: 322323

322323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Lactate_C3H5O3

304785
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3,4-Dihydroxymandelaldehyde_C8H8O4

968794
type: Reaction
reactant: 350562
is: ENSRNOG00000008479.4
is: ENSRNOG00000029871.2
is: ENSRNOG00000001492.4
product: 350586
fast: false
reactant: 350574
notes: R_CAt7r subsystem: Transport, Extracellular R_CAt7r equation: ca2[c] + (3) na1[e] <==> ca2[e] + (3) na1[c]
product: 350599
name: calcium / sodium antiporter (1:3), reversible
reversible: true

350562
type: SpeciesReference
stoichiometry: 1.0
species: 310697

310697
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Calcium_Ca

350586
type: SpeciesReference
stoichiometry: 1.0
species: 310709

310709
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Calcium_Ca

350574
type: SpeciesReference
stoichiometry: 3.0
species: 324628

350599
type: SpeciesReference
stoichiometry: 3.0
species: 324616

971612
type: Reaction
reversible: false
is: http://identifiers.org/ec-code/1.1.1.40
product: 375681
product: 375669
name: malic enzyme (NADP), mitochondrial
fast: false
reactant: 375632
reactant: 375644
is: ENSRNOG00000017311.4
product: 375657
notes: R_ME2m subsystem: Pyruvate Metabolism R_ME2m equation: [m] : mal-L + nadp --> co2 + nadph + pyr

375681
type: SpeciesReference
stoichiometry: 1.0
species: 324881

324881
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3

375669
type: SpeciesReference
stoichiometry: 1.0
species: 328085

328085
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Pyruvate_C3H3O3

375632
type: SpeciesReference
stoichiometry: 1.0
species: 323600

375644
type: SpeciesReference
stoichiometry: 1.0
species: 324821

324821
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3

375657
type: SpeciesReference
stoichiometry: 1.0
species: 311707

311707
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: CO2_CO2

319722
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 13_C55H83N3O61S5

974758
type: Reaction
reactant: 407877
reactant: 407865
product: 408011
reactant: 407926
reactant: 407829
product: 407938
is: ENSRNOG00000030894.1
reactant: 407841
notes: R_THYOXt subsystem: Transport, Extracellular R_THYOXt equation: hco3[c] + thyox-L[e] <==> hco3[e] + thyox-L[c] R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_GCHOLAt subsystem: Transport, Extracellular R_GCHOLAt equation: gchola[e] + hco3[c] <==> gchola[c] + hco3[e] R_PROSTGE2t subsystem: Transport, Extracellular R_PROSTGE2t equation: hco3[c] + prostge2[e] <==> hco3[e] + prostge2[c] R_CHOLATEt subsystem: Transport, Extracellular R_CHOLATEt equation: cholate[e] + hco3[c] <==> cholate[c] + hco3[e] R_TRIODTHYt subsystem: Transport, Extracellular R_TRIODTHYt equation: hco3[c] + triodthy[e] <==> hco3[e] + triodthy[c] R_DHEASt subsystem: Transport, Extracellular R_DHEASt equation: dheas[e] + hco3[c] <==> dheas[c] + hco3[e] R_TCHOLAt subsystem: Transport, Extracellular R_TCHOLAt equation: hco3[c] + tchola[e] <==> hco3[e] + tchola[c] R_ESTRADIOLGLCt subsystem: Transport, Extracellular R_ESTRADIOLGLCt equation: estradiolglc[e] + hco3[c] <==> estradiolglc[c] + hco3[e]
reactant: 407902
product: 408035
reactant: 407889
product: 407963
product: 408023
reactant: 407853
product: 407975
is: ENSRNOG00000031249.1
reversible: true
reactant: 407914
fast: false
product: 407987
product: 408048
reactant: 407817
is: ENSRNOG00000036984.1
product: 407999
product: 407951
is: ENSRNOG00000010388.4

407877
type: SpeciesReference
stoichiometry: 1.0
species: 327712

327712
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Prostaglandin E2_C20H31O5

407865
type: SpeciesReference
stoichiometry: 1.0
species: 317216

317216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: glycocholate_C26H43NO6

408011
type: SpeciesReference
stoichiometry: 1.0
species: 317204

317204
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: glycocholate_C26H43NO6

407926
type: SpeciesReference
stoichiometry: 1.0
species: 315552

315552
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Estrone 3-sulfate_C18H21O5S

407829
type: SpeciesReference
stoichiometry: 1.0
species: 314006

314006
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Dehydroepiandrosterone sulfate_C19H27O5S

407938
type: SpeciesReference
stoichiometry: 1.0
species: 315540

315540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Estrone 3-sulfate_C18H21O5S

407841
type: SpeciesReference
stoichiometry: 9.0
species: 319110

407902
type: SpeciesReference
stoichiometry: 1.0
species: 330502

330502
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Triiodothyronine_C15H12I3NO4

408035
type: SpeciesReference
stoichiometry: 1.0
species: 330490

330490
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Triiodothyronine_C15H12I3NO4

407889
type: SpeciesReference
stoichiometry: 1.0
species: 311121

311121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Cholate_C24H39O5

407963
type: SpeciesReference
stoichiometry: 1.0
species: 315396

315396
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: estradiol glucuronide_C24H32O8

408023
type: SpeciesReference
stoichiometry: 1.0
species: 311109

311109
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Cholate_C24H39O5

407853
type: SpeciesReference
stoichiometry: 1.0
species: 330295

330295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Thyroxine_C15H11I4NO4

407975
type: SpeciesReference
stoichiometry: 1.0
species: 313994

313994
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dehydroepiandrosterone sulfate_C19H27O5S

407914
type: SpeciesReference
stoichiometry: 1.0
species: 315408

315408
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: estradiol glucuronide_C24H32O8

407987
type: SpeciesReference
stoichiometry: 1.0
species: 329536

329536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: taurocholic acid_C26H45NO7S

408048
type: SpeciesReference
stoichiometry: 9.0
species: 319122

407817
type: SpeciesReference
stoichiometry: 1.0
species: 329550

329550
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: taurocholic acid_C26H45NO7S

407999
type: SpeciesReference
stoichiometry: 1.0
species: 330282

330282
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Thyroxine_C15H11I4NO4

407951
type: SpeciesReference
stoichiometry: 1.0
species: 327700

327700
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Prostaglandin E2_C20H31O5

968758
type: Reaction
reactant: 350068
reactant: 350141
product: 350285
reactant: 350117
reactant: 350044
product: 350297
product: 350357
product: 350394
reactant: 350105
product: 350261
product: 350273
reactant: 350189
reactant: 349971
reactant: 349995
is: ENSRNOG00000020606.4
product: 350249
reactant: 350056
product: 350418
product: 350225
is: ENSRNOG00000018267.4
product: 350333
product: 350237
fast: false
product: 350345
reactant: 350093
reactant: 350165
product: 350321
is: ENSRNOG00000008544.2
reactant: 349983
reactant: 350177
is: http://identifiers.org/ec-code/2.4.1.149
is: ENSRNOG00000020110.3
reactant: 350081
reactant: 350129
product: 350406
product: 350382
reactant: 350008
reversible: false
reactant: 350032
product: 350201
product: 350309
reactant: 350020
product: 350213
notes: R_AG13T6g subsystem: Keratan sulfate biosynthesis R_AG13T6g equation: [g] : ksi_pre6 + uacgam --> h + ksi_pre7 + udp R_AG13T17g subsystem: Keratan sulfate biosynthesis R_AG13T17g equation: [g] : ksii_core4_pre4 + uacgam --> h + ksii_core4_pre5 + udp R_AG13T2g subsystem: Keratan sulfate biosynthesis R_AG13T2g equation: [g] : ksii_core2_pre4 + uacgam --> h + ksii_core2_pre5 + udp R_AG13T5g subsystem: Keratan sulfate biosynthesis R_AG13T5g equation: [g] : ksi_pre3 + uacgam --> h + ksi_pre4 + udp R_AG13T8g subsystem: Keratan sulfate biosynthesis R_AG13T8g equation: [g] : ksi_pre12 + uacgam --> h + ksi_pre13 + udp R_AG13T12g subsystem: Keratan sulfate biosynthesis R_AG13T12g equation: [g] : ksi_pre24 + uacgam --> h + ksi_pre25 + udp R_AG13T1g subsystem: Keratan sulfate biosynthesis R_AG13T1g equation: [g] : ksii_core2_pre2 + uacgam --> h + ksii_core2_pre3 + udp R_AG13T10g subsystem: Keratan sulfate biosynthesis R_AG13T10g equation: [g] : ksi_pre18 + uacgam --> h + ksi_pre19 + udp R_AG13T14g subsystem: Keratan sulfate biosynthesis R_AG13T14g equation: [g] : ksi_pre30 + uacgam --> h + ksi_pre31 + udp R_AG13T13g subsystem: Keratan sulfate biosynthesis R_AG13T13g equation: [g] : ksi_pre27 + uacgam --> h + ksi_pre28 + udp R_AG13T9g subsystem: Keratan sulfate biosynthesis R_AG13T9g equation: [g] : ksi_pre15 + uacgam --> h + ksi_pre16 + udp R_AG13T15g subsystem: Keratan sulfate biosynthesis R_AG13T15g equation: [g] : ksi_pre33 + uacgam --> h + ksi_pre34 + udp R_AG13T4g subsystem: Keratan sulfate biosynthesis R_AG13T4g equation: [g] : ksi_pre1 + uacgam --> h + ksi_pre2 + udp R_AG13T11g subsystem: Keratan sulfate biosynthesis R_AG13T11g equation: [g] : ksi_pre21 + uacgam --> h + ksi_pre22 + udp R_AG13T16g subsystem: Keratan sulfate biosynthesis R_AG13T16g equation: [g] : ksii_core4_pre2 + uacgam --> h + ksii_core4_pre3 + udp R_AG13T18g subsystem: Keratan sulfate biosynthesis R_AG13T18g equation: [g] : ksii_core4_pre7 + uacgam --> h + ksii_core4_pre8 + udp R_AG13T7g subsystem: Ker…
reactant: 350153
product: 350370
product: 350430

350068
type: SpeciesReference
stoichiometry: 1.0
species: 321658

321658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 33_C233H372N16O197S10X

350141
type: SpeciesReference
stoichiometry: 1.0
species: 322143

322143
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II boisynthesis, precursor 2_C47H76N4O33X

350285
type: SpeciesReference
stoichiometry: 18.0
species: 318978

350117
type: SpeciesReference
stoichiometry: 1.0
species: 321417

321417
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 15_C149H240N10O119S4X

350044
type: SpeciesReference
stoichiometry: 1.0
species: 321477

321477
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 1_C79H129N5O57X

350297
type: SpeciesReference
stoichiometry: 1.0
species: 321357

321357
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 10_C129H209N9O98S2X

350357
type: SpeciesReference
stoichiometry: 1.0
species: 321961

321961
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 3_C47H76N4O33X

350394
type: SpeciesReference
stoichiometry: 1.0
species: 322179

322179
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 5_C69H112N6O48X

350105
type: SpeciesReference
stoichiometry: 1.0
species: 322009

322009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 7_C67H108N5O51SX

350261
type: SpeciesReference
stoichiometry: 18.0
species: 330850

330850
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: UDP_C9H11N2O12P2

350273
type: SpeciesReference
stoichiometry: 1.0
species: 321757

321757
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 7_C115H187N8O85SX

350189
type: SpeciesReference
stoichiometry: 1.0
species: 321501

321501
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 21_C177H284N12O145S6X

349971
type: SpeciesReference
stoichiometry: 1.0
species: 321622

321622
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 30_C219H350N15O184S9X

349995
type: SpeciesReference
stoichiometry: 1.0
species: 321708

321708
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 3_C93H152N6O67X

350249
type: SpeciesReference
stoichiometry: 1.0
species: 321586

321586
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 28_C213H341N15O176S8X

350056
type: SpeciesReference
stoichiometry: 18.0
species: 330814

330814
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799

350418
type: SpeciesReference
stoichiometry: 1.0
species: 321429

321429
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 16_C157H253N11O124S4X

350225
type: SpeciesReference
stoichiometry: 1.0
species: 322215

322215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 8_C83H134N7O61SX

350333
type: SpeciesReference
stoichiometry: 1.0
species: 321513

321513
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 22_C185H297N13O150S6X

350237
type: SpeciesReference
stoichiometry: 1.0
species: 321634

321634
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 31_C227H363N16O189S9X

350345
type: SpeciesReference
stoichiometry: 1.0
species: 321610

321610
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 2_C87H142N6O62X

350093
type: SpeciesReference
stoichiometry: 1.0
species: 321453

321453
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 18_C163H262N11O132S5X

350165
type: SpeciesReference
stoichiometry: 1.0
species: 321973

321973
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 4_C53H86N4O38X

350321
type: SpeciesReference
stoichiometry: 1.0
species: 322021

322021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 8_C75H121N6O56SX

349983
type: SpeciesReference
stoichiometry: 1.0
species: 321574

321574
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 27_C205H328N14O171S8X

350177
type: SpeciesReference
stoichiometry: 1.0
species: 321745

321745
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 6_C107H174N7O80SX

350081
type: SpeciesReference
stoichiometry: 1.0
species: 321781

321781
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 9_C121H196N8O93S2X

350129
type: SpeciesReference
stoichiometry: 1.0
species: 321949

321949
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 2_C39H63N3O28X

350406
type: SpeciesReference
stoichiometry: 1.0
species: 321670

321670
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 34_C241H385N17O202S10X

350382
type: SpeciesReference
stoichiometry: 1.0
species: 321721

321721
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 4_C101H165N7O72X

350008
type: SpeciesReference
stoichiometry: 1.0
species: 322203

322203
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 7_C75H121N6O56SX

350032
type: SpeciesReference
stoichiometry: 1.0
species: 321381

321381
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 12_C135H218N9O106S3X

350201
type: SpeciesReference
stoichiometry: 1.0
species: 322155

322155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 3_C55H89N5O38X

350309
type: SpeciesReference
stoichiometry: 1.0
species: 321985

321985
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 5_C61H99N5O43X

350020
type: SpeciesReference
stoichiometry: 1.0
species: 321537

350213
type: SpeciesReference
stoichiometry: 1.0
species: 321550

321550
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 25_C199H319N14O163S7X

350153
type: SpeciesReference
stoichiometry: 1.0
species: 322167

322167
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 4_C61H99N5O43X

350370
type: SpeciesReference
stoichiometry: 1.0
species: 321393

321393
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 13_C143H231N10O111S3X

350430
type: SpeciesReference
stoichiometry: 1.0
species: 321465

321465
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 19_C171H275N12O137S5X

305484
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Phosphohydroxypyruvate_C3H2O7P

968241
type: Reaction
reactant: 345086
name: (R)-3-Hydroxybutanoate:NAD+ oxidoreductase
notes: R_BDHm subsystem: Butanoate Metabolism R_BDHm equation: [m] : bhb + nad <==> acac + h + nadh
is: ENSRNOG00000001736.4
reversible: true
product: 345098
reactant: 345074
product: 345122
product: 345110
is: http://identifiers.org/ec-code/1.1.1.30
fast: false

345086
type: SpeciesReference
stoichiometry: 1.0
species: 324700

324700
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2

345098
type: SpeciesReference
stoichiometry: 1.0
species: 307753

307753
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Acetoacetate_C4H5O3

345074
type: SpeciesReference
stoichiometry: 1.0
species: 310299

310299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: (R)-3-Hydroxybutanoate_C4H7O3

345122
type: SpeciesReference
stoichiometry: 1.0
species: 324761

324761
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2

345110
type: SpeciesReference
stoichiometry: 1.0
species: 319002

331828
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _7-alpha,24(S)-Dihydroxycholesterol_C27H46O3

975059
type: Reaction
fast: false
product: 410278
notes: R_ECOAH12m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ECOAH12m equation: [m] : 2mp2coa + h2o <==> 3hibutcoa R_PRPNCOAHYDm subsystem: beta-Alanine metabolism R_PRPNCOAHYDm equation: [m] : h2o + prpncoa --> 3hpcoa R_ECOAH9m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ECOAH9m equation: [m] : 2mb2coa + h2o <==> 3hmbcoa R_ECOAH1m subsystem: Tryptophan metabolism R_ECOAH1m equation: [m] : 3hbcoa <==> b2coa + h2o
modifier: 410326
reactant: 410254
modifier: 410362
is: ENSRNOG00000018522.3
modifier: 410290
modifier: 410314
modifier: 410302
reversible: false
modifier: 410350
modifier: 410338
reactant: 410266
is: http://identifiers.org/ec-code/4.2.1.17

410278
type: SpeciesReference
stoichiometry: 1.0
species: 305158

305158
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Hydroxypropionyl-CoA_C24H36N7O18P3S

310215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Crotonoyl-CoA_C25H36N7O17P3S

410254
type: SpeciesReference
stoichiometry: 1.0
species: 318894

305122
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

305085
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

304665
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

304701
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

410266
type: SpeciesReference
stoichiometry: 1.0
species: 327796

331199
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Uracil_C4H4N2O2

967592
type: Reaction
reactant: 338978
reactant: 338990
product: 339038
product: 339063
reversible: false
product: 339087
fast: false
notes: R_THMDt5 subsystem: Transport, Extracellular R_THMDt5 equation: (2) na1[e] + thymd[e] --> (2) na1[c] + thymd[c] R_CYTDt4 subsystem: Transport, Extracellular R_CYTDt4 equation: cytd[e] + na1[e] --> cytd[c] + na1[c] R_URIt5 subsystem: Transport, Extracellular R_URIt5 equation: (2) na1[e] + uri[e] --> (2) na1[c] + uri[c] R_GSNt5 subsystem: Transport, Extracellular R_GSNt5 equation: gsn[e] + (2) na1[e] --> gsn[c] + (2) na1[c] R_CYTDt5 subsystem: Transport, Extracellular R_CYTDt5 equation: cytd[e] + (2) na1[e] --> cytd[c] + (2) na1[c] R_INSt5 subsystem: Transport, Extracellular R_INSt5 equation: ins[e] + (2) na1[e] --> ins[c] + (2) na1[c] R_ADNt4 subsystem: Transport, Extracellular R_ADNt4 equation: adn[e] + na1[e] --> adn[c] + na1[c] R_URIt4 subsystem: Transport, Extracellular R_URIt4 equation: na1[e] + uri[e] --> na1[c] + uri[c] R_THMDt4 subsystem: Transport, Extracellular R_THMDt4 equation: na1[e] + thymd[e] --> na1[c] + thymd[c] R_INSt4 subsystem: Transport, Extracellular R_INSt4 equation: ins[e] + na1[e] --> ins[c] + na1[c] R_GSNt4 subsystem: Transport, Extracellular R_GSNt4 equation: gsn[e] + na1[e] --> gsn[c] + na1[c] R_ADNt5 subsystem: Transport, Extracellular R_ADNt5 equation: adn[e] + (2) na1[e] --> adn[c] + (2) na1[c]
product: 339051
reactant: 338942
reactant: 339002
reactant: 338954
product: 339026
reactant: 339014
product: 339099
reactant: 338966
is: ENSRNOG00000018853.2
product: 339075

338978
type: SpeciesReference
stoichiometry: 2.0
species: 308573

338990
type: SpeciesReference
stoichiometry: 2.0
species: 318462

339038
type: SpeciesReference
stoichiometry: 2.0
species: 318450

339063
type: SpeciesReference
stoichiometry: 2.0
species: 320608

339087
type: SpeciesReference
stoichiometry: 2.0
species: 312978

339051
type: SpeciesReference
stoichiometry: 2.0
species: 308561

338942
type: SpeciesReference
stoichiometry: 2.0
species: 331284

339002
type: SpeciesReference
stoichiometry: 2.0
species: 320620

338954
type: SpeciesReference
stoichiometry: 2.0
species: 330246

339026
type: SpeciesReference
stoichiometry: 2.0
species: 330234

339014
type: SpeciesReference
stoichiometry: 18.0
species: 324628

339099
type: SpeciesReference
stoichiometry: 18.0
species: 324616

338966
type: SpeciesReference
stoichiometry: 2.0
species: 312990

339075
type: SpeciesReference
stoichiometry: 2.0
species: 331272

322963
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: gamma-linolenoyl-CoA_C39H60N7O17P3S

320295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Iodide_I

312748
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5b_C45H64N2O51S5X

313740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Deoxyguanosine_C10H13N5O4

971540
type: Reaction
fast: false
is: ENSRNOG00000014726.3
reactant: 373939
reversible: false
reactant: 373926
notes: R_FACOAL40im subsystem: Fatty acid activation R_FACOAL40im equation: [m] : atp + but + coa --> amp + btcoa + ppi
name: fatty-acid--CoA ligase (butanoate), mitochondrial
product: 373963
product: 373951
is: http://identifiers.org/ec-code/6.2.1.2
reactant: 373914
product: 373975

373939
type: SpeciesReference
stoichiometry: 1.0
species: 310166

310166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: ATP_C10H12N5O13P3

373926
type: SpeciesReference
stoichiometry: 1.0
species: 311797

373963
type: SpeciesReference
stoichiometry: 1.0
species: 310504

310504
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Butanoyl-CoA_C25H38N7O17P3S

373951
type: SpeciesReference
stoichiometry: 1.0
species: 309504

309504
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: AMP_C10H12N5O7P

373914
type: SpeciesReference
stoichiometry: 1.0
species: 310588

373975
type: SpeciesReference
stoichiometry: 1.0
species: 327169

327169
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Diphosphate_HO7P2

318630
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Reduced glutathione_C10H16N3O6S

310745
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: cAMP_C10H11N5O6P

324180
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3

326216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: phosphatidylinositol 4,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2

329590
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Thiocyanate_CNS

318702
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: GTP_C10H12N5O14P3

331706
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _7alpha-Hydroxy-5beta-cholestan-3-one_C27H46O2

317422
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: GDP-L-fucose_C16H23N5O15P2

976751
type: Reaction
reactant: 425528
product: 425564
is: ENSRNOG00000024144.2
notes: R_CDIPTr subsystem: Glycerophospholipid Metabolism R_CDIPTr equation: [c] : cdpdag_hs + inost <==> cmp + h + pail_hs
is: http://identifiers.org/ec-code/2.7.8.11
fast: false
name: phosphatidylinositol synthase (Homo sapiens)
reversible: true
product: 425576
product: 425552
reactant: 425540

425528
type: SpeciesReference
stoichiometry: 1.0
species: 320584

320584
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: myo-Inositol_C6H12O6

425564
type: SpeciesReference
stoichiometry: 1.0
species: 326288

326288
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2

425576
type: SpeciesReference
stoichiometry: 1.0
species: 318954

425552
type: SpeciesReference
stoichiometry: 1.0
species: 311558

425540
type: SpeciesReference
stoichiometry: 1.0
species: 310939

975611
type: Reaction
product: 415502
fast: false
reactant: 415466
product: 415514
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1
reversible: false
product: 415490
reactant: 415454
is: ENSRNOG00000009850.4
product: 415478
reactant: 415442
is: http://identifiers.org/ec-code/2.4.99.4

415502
type: SpeciesReference
stoichiometry: 1.0
species: 322143

415466
type: SpeciesReference
stoichiometry: 1.0
species: 311857

311857
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Core 2_C22H37N2O15X

415514
type: SpeciesReference
stoichiometry: 2.0
species: 311582

311582
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: CMP_C9H12N3O8P

415490
type: SpeciesReference
stoichiometry: 1.0
species: 321937

321937
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 1_C33H53N3O23X

415454
type: SpeciesReference
stoichiometry: 1.0
species: 322131

322131
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 1_C36H60N3O25X

415478
type: SpeciesReference
stoichiometry: 2.0
species: 318978

415442
type: SpeciesReference
stoichiometry: 2.0
species: 311630

311630
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: CMP-N-acetylneuraminate_C20H29N4O16P

314295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dihomo-gamma-linolenyl coenzyme A_C41H64N7O17P3S

328532
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: sialyl-Tn antigen_C19H30N2O13X

330947
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775

967050
type: Reaction
notes: R_LGTHL subsystem: Pyruvate Metabolism R_LGTHL equation: [c] : gthrd + mthgxl --> lgt-S
is: http://identifiers.org/ec-code/4.4.1.5
is: ENSRNOG00000000541.4
product: 334203
fast: false
name: lactoylglutathione lyase
reactant: 334178
reactant: 334190
reversible: false

334203
type: SpeciesReference
stoichiometry: 1.0
species: 322699

322699
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (R)-S-Lactoylglutathione_C13H20N3O8S

334178
type: SpeciesReference
stoichiometry: 1.0
species: 318618

318618
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Reduced glutathione_C10H16N3O6S

334190
type: SpeciesReference
stoichiometry: 1.0
species: 324447

324447
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Methylglyoxal_C3H4O2

307765
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Acetoacetate_C4H5O3

305788
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _4-Hydroxybenzoate_C7H5O3

323383
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1605H2640N20O520P20

968926
type: Reaction
is: ENSRNOG00000001547.3
fast: false
notes: R_AGPSx subsystem: Glycerophospholipid Metabolism R_AGPSx equation: [x] : adhap_hs + alkylR1oh --> Rtotal + akdhap_hs + h
name: alkylglycerone phosphate synthase
product: 351793
reactant: 351781
is: http://identifiers.org/ec-code/2.5.1.26
reactant: 351769
product: 351805
product: 351817
reversible: false

351793
type: SpeciesReference
stoichiometry: 1.0
species: 309094

309094
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _1-alkyldihydroxyacetone phosphate_C3H4O6PFULLRC2H4

351781
type: SpeciesReference
stoichiometry: 1.0
species: 308549

308549
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: acyl-dihydroxyacetone phosphate_C3H4O6PFULLRCO

351769
type: SpeciesReference
stoichiometry: 1.0
species: 309323

309323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: hydroxy alkyl chain_C2H5OFULLR

351805
type: SpeciesReference
stoichiometry: 1.0
species: 307403

307403
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: R total_CO2FULLR

351817
type: SpeciesReference
stoichiometry: 1.0
species: 319038

319038
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: H+_H

308187
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GlcNAc-Gal globoside (homo sapiens)_C58H102N3O32FULLRCO

977291
type: Reaction
reactant: 432009
is: ENSRNOG00000018211.3
name: uroporphyrinogen decarboxylase (uroporphyrinogen III)
notes: R_UPPDC1 subsystem: Heme Biosynthesis R_UPPDC1 equation: [c] : (4) h + uppg3 --> (4) co2 + cpppg3
reactant: 431996
product: 432021
is: http://identifiers.org/ec-code/4.1.1.37
fast: false
reversible: false
product: 432033

432009
type: SpeciesReference
stoichiometry: 4.0
species: 318954

431996
type: SpeciesReference
stoichiometry: 1.0
species: 331175

331175
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Uroporphyrinogen III_C40H36N4O16

432021
type: SpeciesReference
stoichiometry: 4.0
species: 311681

432033
type: SpeciesReference
stoichiometry: 1.0
species: 311942

311942
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Coproporphyrinogen III_C36H40N4O8

315324
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775

304389
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _1-Pyrroline-5-carboxylate_C5H6NO2

972921
type: Reaction
product: 388343
reactant: 388319
reactant: 388331
product: 388379
reactant: 388307
product: 388355
reactant: 388295
fast: false
reversible: false
reactant: 388283
is: http://identifiers.org/ec-code/1.14.19.1
is: ENSRNOG00000020480.3
notes: R_DESAT20_1 subsystem: Fatty acid elongation R_DESAT20_1 equation: [c] : dlnlcgcoa + h + nadh + o2 --> arachdcoa + (2) h2o + nad R_DESAT20_2 subsystem: Fatty acid elongation R_DESAT20_2 equation: [c] : eicostetcoa + h + nadh + o2 --> (2) h2o + nad + tmndnccoa
product: 388367

388343
type: SpeciesReference
stoichiometry: 1.0
species: 309888

388319
type: SpeciesReference
stoichiometry: 2.0
species: 318954

388331
type: SpeciesReference
stoichiometry: 2.0
species: 324749

388379
type: SpeciesReference
stoichiometry: 4.0
species: 318846

388307
type: SpeciesReference
stoichiometry: 2.0
species: 325392

325392
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: O2_O2

388355
type: SpeciesReference
stoichiometry: 2.0
species: 324676

388295
type: SpeciesReference
stoichiometry: 1.0
species: 315227

388283
type: SpeciesReference
stoichiometry: 1.0
species: 314283

388367
type: SpeciesReference
stoichiometry: 1.0
species: 330344

316371
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)4 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1_C84H145N4O50FULLRCO

306221
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate_C9H11N3O9P

317385
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: GDP_C10H12N5O11P2

317943
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glycine betaine_C5H11NO2

974362
type: Reaction
product: 404933
notes: R_PI4PLC subsystem: Inositol Phosphate Metabolism R_PI4PLC equation: [c] : h2o + pail4p_hs --> dag_hs + h + mi14p R_PI45PLC subsystem: Inositol Phosphate Metabolism R_PI45PLC equation: [c] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLC subsystem: Inositol Phosphate Metabolism R_PIPLC equation: [c] : h2o + pail_hs --> dag_hs + h + mi1p-D
product: 404921
reactant: 404849
is: ENSRNOG00000016340.4
is: ENSRNOG00000008514.4
is: ENSRNOG00000032659.1
is: ENSRNOG00000016361.4
product: 404909
is: ENSRNOG00000002171.4
product: 404885
is: ENSRNOG00000021150.4
is: ENSRNOG00000032238.2
is: ENSRNOG00000014226.4
is: http://identifiers.org/ec-code/3.1.4.3
fast: false
reactant: 404837
is: ENSRNOG00000008229.4
is: http://identifiers.org/ec-code/3.1.4.11
reactant: 404861
is: ENSRNOG00000003033.4
is: ENSRNOG00000013676.4
is: ENSRNOG00000009955.4
reactant: 404873
reversible: false
product: 404897
is: ENSRNOG00000033119.2
is: ENSRNOG00000014276.3

404933
type: SpeciesReference
stoichiometry: 3.0
species: 318954

404921
type: SpeciesReference
stoichiometry: 1.0
species: 324192

324192
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1,4-bisphosphate_C6H10O12P2

404849
type: SpeciesReference
stoichiometry: 1.0
species: 326288

404909
type: SpeciesReference
stoichiometry: 1.0
species: 324168

324168
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1,4,5-trisphosphate_C6H9O15P3

404885
type: SpeciesReference
stoichiometry: 3.0
species: 313110

404837
type: SpeciesReference
stoichiometry: 1.0
species: 326203

326203
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylinositol 4,5-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2

404861
type: SpeciesReference
stoichiometry: 1.0
species: 326228

326228
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2

404873
type: SpeciesReference
stoichiometry: 3.0
species: 318846

404897
type: SpeciesReference
stoichiometry: 1.0
species: 324216

324216
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1-phosphate_C6H11O9P

327290
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Protoporphyrinogen IX_C34H38N4O4

304689
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Methyl-3-oxopropanoate_C4H5O3

973678
type: Reaction
notes: R_BHMT subsystem: Glycine, Serine, and Threonine Metabolism R_BHMT equation: [c] : glyb + hcys-L --> dmgly + met-L
is: http://identifiers.org/ec-code/2.1.1.5
product: 395711
is: ENSRNOG00000040120.1
product: 395699
name: betaine-homocysteine S-methyltransferase
reactant: 395675
reversible: false
fast: false
is: ENSRNOG00000011200.2
reactant: 395687

395711
type: SpeciesReference
stoichiometry: 1.0
species: 323987

323987
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Methionine_C5H11NO2S

395699
type: SpeciesReference
stoichiometry: 1.0
species: 314343

314343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N,N-Dimethylglycine_C4H9NO2

395675
type: SpeciesReference
stoichiometry: 1.0
species: 319158

319158
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Homocysteine_C4H9NO2S

395687
type: SpeciesReference
stoichiometry: 1.0
species: 317943

311930
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: coumarin_C9H6O2

314187
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Digalactosylceramide_C30H56NO12FULLRCO

329354
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Succinate_C4H4O4

321913
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 2-linked)_C81H129N6O67S3X

325476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Superoxide anion_O2

314259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dITP_C10H11N4O13P3

322349
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Lactate_C3H5O3

977435
type: Reaction
fast: false
reactant: 433534
reactant: 433546
reversible: false
product: 433582
is: ENSRNOG00000004710.4
product: 433570
product: 433594
product: 433558
is: http://identifiers.org/ec-code/2.7.1.15
reactant: 433522
notes: R_RBK subsystem: Pentose Phosphate Pathway R_RBK equation: [c] : atp + rib-D --> adp + h + r5p R_DRBK subsystem: Pentose Phosphate Pathway R_DRBK equation: [c] : atp + drib --> 2dr5p + adp + h

433534
type: SpeciesReference
stoichiometry: 2.0
species: 310142

310142
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: ATP_C10H12N5O13P3

433546
type: SpeciesReference
stoichiometry: 1.0
species: 314754

314754
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deoxyribose_C5H10O4

433582
type: SpeciesReference
stoichiometry: 1.0
species: 304605

304605
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Deoxy-D-ribose 5-phosphate_C5H9O7P

433570
type: SpeciesReference
stoichiometry: 2.0
species: 308621

308621
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: ADP_C10H12N5O10P2

433594
type: SpeciesReference
stoichiometry: 2.0
species: 318954

433558
type: SpeciesReference
stoichiometry: 1.0
species: 328181

328181
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-D-Ribose 5-phosphate_C5H9O8P

433522
type: SpeciesReference
stoichiometry: 1.0
species: 328352

328352
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Ribose_C5H10O5

316902
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: I-antigen_C72H125N4O42FULLRCO

319350
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _4,17 dihydroxy estradiol_C18H24O3

973029
type: Reaction
product: 389093
is: ENSRNOG00000003205.4
reversible: true
reactant: 389057
fast: false
product: 389117
reactant: 389069
notes: R_TAURt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_TAURt4_LPAREN_2_RPAREN_r equation: (2) na1[e] + taur[e] <==> (2) na1[c] + taur[c] R_TAURtcx subsystem: Taurine and hypotaurine metabolism R_TAURtcx equation: na1[c] + taur[c] <==> na1[x] + taur[x]
reactant: 389045
product: 389129
reactant: 389081
product: 389105

389093
type: SpeciesReference
stoichiometry: 1.0
species: 329486

329486
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Taurine_C2H7NO3S

389057
type: SpeciesReference
stoichiometry: 2.0
species: 324628

389117
type: SpeciesReference
stoichiometry: 2.0
species: 324616

389069
type: SpeciesReference
stoichiometry: 1.0
species: 324616

389045
type: SpeciesReference
stoichiometry: 1.0
species: 329486

389129
type: SpeciesReference
stoichiometry: 1.0
species: 329510

389081
type: SpeciesReference
stoichiometry: 1.0
species: 329498

329498
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Taurine_C2H7NO3S

389105
type: SpeciesReference
stoichiometry: 1.0
species: 324652

324652
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Sodium_Na

320125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 5_C59H89N3O47X

975839
type: Reaction
is: ENSRNOG00000018367.3
reactant: 417188
notes: R_TALA subsystem: Pentose Phosphate Pathway R_TALA equation: [c] : g3p + s7p <==> e4p + f6p
fast: false
product: 417213
reactant: 417176
product: 417200
name: transaldolase
reversible: true
is: http://identifiers.org/ec-code/2.2.1.2

417188
type: SpeciesReference
stoichiometry: 1.0
species: 316696

316696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glyceraldehyde 3-phosphate_C3H5O6P

417213
type: SpeciesReference
stoichiometry: 1.0
species: 315130

417176
type: SpeciesReference
stoichiometry: 1.0
species: 328508

328508
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sedoheptulose 7-phosphate_C7H13O10P

417200
type: SpeciesReference
stoichiometry: 1.0
species: 315708

317835
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glyoxylate_C2H1O3

306113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5,6-dihydrouracil_C4H6N2O2

976055
type: Reaction
fast: false
name: alpha-N-acetylglucosaminyltransferase I, Golgi apparatus
is: ENSRNOG00000014323.4
product: 419393
reactant: 419369
product: 419381
reversible: false
product: 419405
reactant: 419357
notes: R_GLCNACT1g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCNACT1g equation: [g] : cs,hs_linkage + uacgam --> h + hs_pre1 + udp

419393
type: SpeciesReference
stoichiometry: 1.0
species: 330850

419369
type: SpeciesReference
stoichiometry: 1.0
species: 312170

312170
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate/heparan sulfate linkage region (GlcA-(Gal)2-Xyl-L-Ser (protein))_C23H36O20X

419381
type: SpeciesReference
stoichiometry: 1.0
species: 320076

320076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 1_C31H49NO25X

419405
type: SpeciesReference
stoichiometry: 1.0
species: 318978

419357
type: SpeciesReference
stoichiometry: 1.0
species: 330814

322663
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: lignocericyl coenzyme A_C45H78N7O17P3S

327048
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (R)-Pantothenate_C9H16NO5

320848
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 13_C174H280N12O150S8

316335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799

973305
type: Reaction
is: ENSRNOG00000016163.4
reactant: 391411
is: ENSRNOG00000011644.3
is: ENSRNOG00000014816.4
reactant: 391363
product: 391459
reactant: 391399
is: ENSRNOG00000013742.3
reactant: 391375
product: 391435
product: 391483
notes: R_GLUt6 subsystem: Transport, Extracellular R_GLUt6 equation: glu-L[e] + h[e] + k[c] + (3) na1[e] --> glu-L[c] + h[c] + k[e] + (3) na1[c] R_ASPDt6 subsystem: Transport, Extracellular R_ASPDt6 equation: asp-D[e] + h[e] + k[c] + (3) na1[e] --> asp-D[c] + h[c] + k[e] + (3) na1[c] R_ASPt6 subsystem: Transport, Extracellular R_ASPt6 equation: asp-L[e] + h[e] + k[c] + (3) na1[e] --> asp-L[c] + h[c] + k[e] + (3) na1[c]
reversible: false
product: 391447
reactant: 391351
product: 391423
fast: false
reactant: 391387
product: 391471
is: ENSRNOG00000005479.4

391411
type: SpeciesReference
stoichiometry: 1.0
species: 310082

310082
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Aspartate_C4H6NO4

391363
type: SpeciesReference
stoichiometry: 3.0
species: 320764

320764
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: potassium_K

391459
type: SpeciesReference
stoichiometry: 1.0
species: 317683

391399
type: SpeciesReference
stoichiometry: 1.0
species: 317696

317696
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Glutamate_C5H8NO4

391375
type: SpeciesReference
stoichiometry: 1.0
species: 310118

310118
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Aspartate_C4H6NO4

391435
type: SpeciesReference
stoichiometry: 1.0
species: 310070

391483
type: SpeciesReference
stoichiometry: 3.0
species: 318954

391447
type: SpeciesReference
stoichiometry: 9.0
species: 324616

391351
type: SpeciesReference
stoichiometry: 3.0
species: 318966

391423
type: SpeciesReference
stoichiometry: 3.0
species: 320776

320776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: potassium_K

391387
type: SpeciesReference
stoichiometry: 9.0
species: 324628

391471
type: SpeciesReference
stoichiometry: 1.0
species: 310106

310106
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Aspartate_C4H6NO4

317349
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: GDP_C10H12N5O11P2

328133
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Ubiquinol-10_C59H92O4

324314
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _5,10-Methylenetetrahydrofolate_C20H21N7O6

967796
type: Reaction
is: http://identifiers.org/ec-code/1.15.1.1
notes: R_SPODMm subsystem: ROS Detoxification R_SPODMm equation: [m] : (2) h + (2) o2s --> h2o2 + o2
product: 341163
is: ENSRNOG00000019048.3
fast: false
product: 341151
reversible: false
reactant: 341127
name: superoxide dismutase
reactant: 341139

341163
type: SpeciesReference
stoichiometry: 1.0
species: 325416

325416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: O2_O2

341151
type: SpeciesReference
stoichiometry: 1.0
species: 318810

318810
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Hydrogen peroxide_H2O2

341127
type: SpeciesReference
stoichiometry: 2.0
species: 325488

325488
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Superoxide anion_O2

341139
type: SpeciesReference
stoichiometry: 2.0
species: 319002

975803
type: Reaction
reversible: false
notes: R_DHAPA subsystem: Triacylglycerol Synthesis R_DHAPA equation: [c] : Rtotalcoa + dhap --> adhap_hs + coa R_DHAPAx subsystem: Triacylglycerol Synthesis R_DHAPAx equation: [x] : Rtotalcoa + dhap --> adhap_hs + coa
reactant: 416935
product: 417019
reactant: 416971
product: 417007
reactant: 416947
is: ENSRNOG00000019205.4
is: http://identifiers.org/ec-code/2.3.1.42
product: 416995
fast: false
reactant: 416959
product: 416983

416935
type: SpeciesReference
stoichiometry: 1.0
species: 313812

313812
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dihydroxyacetone phosphate_C3H5O6P

417019
type: SpeciesReference
stoichiometry: 1.0
species: 308549

416971
type: SpeciesReference
stoichiometry: 1.0
species: 313825

313825
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Dihydroxyacetone phosphate_C3H5O6P

417007
type: SpeciesReference
stoichiometry: 1.0
species: 308537

308537
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: acyl-dihydroxyacetone phosphate_C3H4O6PFULLRCO

416947
type: SpeciesReference
stoichiometry: 1.0
species: 307415

416995
type: SpeciesReference
stoichiometry: 1.0
species: 311833

416959
type: SpeciesReference
stoichiometry: 1.0
species: 307439

307439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: R total Coenzyme A_CO2FULLRC21H31N7O15P3S

416983
type: SpeciesReference
stoichiometry: 1.0
species: 311759

311352
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: chitin_C24H41N3O16

972092
type: Reaction
is: http://identifiers.org/ec-code/4.1.1.36
reactant: 380824
reactant: 380836
reversible: false
product: 380860
name: phosphopantothenoylcysteine decarboxylase
fast: false
product: 380848
notes: R_PPCDC subsystem: CoA Biosynthesis R_PPCDC equation: [c] : 4ppcys + h --> co2 + pan4p
is: ENSRNOG00000018711.4

380824
type: SpeciesReference
stoichiometry: 1.0
species: 306027

306027
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-((R)-4-Phosphopantothenoyl)-L-cysteine_C12H20N2O9PS

380836
type: SpeciesReference
stoichiometry: 1.0
species: 318954

380860
type: SpeciesReference
stoichiometry: 1.0
species: 311681

380848
type: SpeciesReference
stoichiometry: 1.0
species: 326337

326337
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pantetheine 4'-phosphate_C11H21N2O7PS

315178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: hydroxylated ebastine_C32H39NO3

312158
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: cervonic acid, C22:6 n-3_C22H31O2

321405
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 14_C143H230N10O114S4X

314729
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dephospho-CoA_C21H33N7O13P2S

967086
type: Reaction
reactant: 334396
is: ENSRNOG00000005794.3
product: 334432
notes: R_TCHOLAt2 subsystem: Transport, Extracellular R_TCHOLAt2 equation: (2) na1[e] + tchola[e] --> (2) na1[c] + tchola[c] R_ESTRONESt2 subsystem: Transport, Extracellular R_ESTRONESt2 equation: estrones[e] + (2) na1[e] --> estrones[c] + (2) na1[c] R_CHOLATEt2 subsystem: Transport, Extracellular R_CHOLATEt2 equation: cholate[e] + (2) na1[e] --> cholate[c] + (2) na1[c] R_GCHOLAt2 subsystem: Transport, Extracellular R_GCHOLAt2 equation: gchola[e] + (2) na1[e] --> gchola[c] + (2) na1[c]
product: 334457
product: 334420
product: 334408
fast: false
reactant: 334348
reactant: 334360
product: 334444
reactant: 334372
reversible: false
reactant: 334384

334396
type: SpeciesReference
stoichiometry: 1.0
species: 311121

334432
type: SpeciesReference
stoichiometry: 1.0
species: 329536

334457
type: SpeciesReference
stoichiometry: 8.0
species: 324616

334420
type: SpeciesReference
stoichiometry: 1.0
species: 311109

334408
type: SpeciesReference
stoichiometry: 1.0
species: 315540

334348
type: SpeciesReference
stoichiometry: 1.0
species: 329550

334360
type: SpeciesReference
stoichiometry: 1.0
species: 317216

334444
type: SpeciesReference
stoichiometry: 1.0
species: 317204

334372
type: SpeciesReference
stoichiometry: 8.0
species: 324628

334384
type: SpeciesReference
stoichiometry: 1.0
species: 315552

307379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: R total_CO2FULLR

310372
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Bilirubin monoglucuronide_C39H44N4O12

322555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: w-hydroxyl leukotriene B4_C20H31O5

325295
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: nervonic acid_C24H45O2

967423
type: Reaction
name: inorganic diphosphatase
is: http://identifiers.org/ec-code/3.6.1.1
notes: R_PPA subsystem: Oxidative Phosphorylation R_PPA equation: [c] : h2o + ppi --> h + (2) pi
reactant: 337761
is: ENSRNOG00000000558.4
product: 337785
product: 337797
reversible: false
fast: false
reactant: 337773

337761
type: SpeciesReference
stoichiometry: 1.0
species: 318846

337785
type: SpeciesReference
stoichiometry: 2.0
species: 326891

326891
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phosphate_HO4P

337797
type: SpeciesReference
stoichiometry: 1.0
species: 318954

337773
type: SpeciesReference
stoichiometry: 1.0
species: 327157

970119
type: Reaction
reactant: 361558
is: http://identifiers.org/ec-code/2.8.2.23
is: ENSRNOG00000024591.2
reactant: 361546
name: heparin-glucosamine 3-O-sulfotransferase
reversible: false
product: 361582
product: 361570
fast: false
notes: R_S3T3g subsystem: Chondroitin / heparan sulfate biosynthesis R_S3T3g equation: [g] : hs_pre15 + paps --> h + hspg + pap
is: ENSRNOG00000014672.3
product: 361594

361558
type: SpeciesReference
stoichiometry: 1.0
species: 326385

361546
type: SpeciesReference
stoichiometry: 1.0
species: 320064

320064
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 15_C79H114N5O98S11X

361582
type: SpeciesReference
stoichiometry: 1.0
species: 320186

320186
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate proteoglycan_C79H113N5O101S12X

361570
type: SpeciesReference
stoichiometry: 1.0
species: 318978

361594
type: SpeciesReference
stoichiometry: 1.0
species: 326361

328025
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyridoxine_C8H11NO3

321296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 8_C194H311N13O171S10

W3 CDTF: Fri Feb 03 12:41:13 GMT 2012

331067
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: UDP-D-xylose_C14H20N2O16P2

307003
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Dopachrome_C9H6NO4

974398
type: Reaction
product: 405175
product: 405151
reactant: 405139
reactant: 405102
is: ENSRNOG00000016265.4
product: 405187
fast: false
reactant: 405114
is: http://identifiers.org/ec-code/6.2.1.3
notes: R_FACOAL180i subsystem: Fatty acid activation R_FACOAL180i equation: [c] : atp + coa + ocdca --> amp + ppi + stcoa R_FACOAL160i subsystem: Fatty acid activation R_FACOAL160i equation: [c] : atp + coa + hdca --> amp + pmtcoa + ppi
reversible: false
reactant: 405127
product: 405163

405175
type: SpeciesReference
stoichiometry: 2.0
species: 309455

309455
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: AMP_C10H12N5O7P

405151
type: SpeciesReference
stoichiometry: 1.0
species: 326987

405139
type: SpeciesReference
stoichiometry: 1.0
species: 325658

325658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: octadecanoate (n-C18:0)_C18H35O2

405102
type: SpeciesReference
stoichiometry: 1.0
species: 319170

319170
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hexadecanoate (n-C16:0)_C16H31O2

405187
type: SpeciesReference
stoichiometry: 2.0
species: 327157

405114
type: SpeciesReference
stoichiometry: 2.0
species: 311759

405127
type: SpeciesReference
stoichiometry: 2.0
species: 310142

405163
type: SpeciesReference
stoichiometry: 1.0
species: 329160

976223
type: Reaction
product: 420308
fast: false
product: 420321
product: 420296
reactant: 420260
is: ENSRNOG00000008931.3
reversible: true
reactant: 420284
notes: R_2OXOADPTm subsystem: Tryptophan metabolism R_2OXOADPTm equation: _2oxoadp[c] + akg[m] <==> 2oxoadp[m] + akg[c] R_2AMADPTm subsystem: Lysine Metabolism R_2AMADPTm equation: L2aadp[c] + akg[m] <==> L2aadp[m] + akg[c]
reactant: 420272

420308
type: SpeciesReference
stoichiometry: 1.0
species: 304737

304737
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Oxoadipate_C6H6O5

420321
type: SpeciesReference
stoichiometry: 2.0
species: 309106

309106
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Oxoglutarate_C5H4O5

420296
type: SpeciesReference
stoichiometry: 1.0
species: 306991

306991
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-2-Aminoadipate_C6H10NO4

420260
type: SpeciesReference
stoichiometry: 1.0
species: 304725

304725
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Oxoadipate_C6H6O5

420284
type: SpeciesReference
stoichiometry: 2.0
species: 309130

309130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Oxoglutarate_C5H4O5

420272
type: SpeciesReference
stoichiometry: 1.0
species: 306979

306979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-2-Aminoadipate_C6H10NO4

312507
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 4_C31H47NO35S3

325853
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: hydroxide ion_HO

328929
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Sulfate_O4S

327724
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Prostaglandin E2_C20H31O5

319674
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Hydroxypyruvate_C3H3O4

306173
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5alpha-Dihydrotestosterone glucuronide_C25H38O8

324471
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: ((N-acetyl-D-glucosaminyl)2-(alpha-D-mannosyl)2-beta-D-mannosyl-diacetylchitobiosyl)-L-asparagine (protein)_C50H83N4O35X

974927
type: Reaction
product: 409289
reactant: 409205
product: 409253
reversible: false
is: ENSRNOG00000020083.3
product: 409277
fast: false
reactant: 409229
product: 409241
reactant: 409217
product: 409265
is: http://identifiers.org/ec-code/4.4.1.16
notes: R_SELCYSLY2 subsystem: Selenoamino acid metabolism R_SELCYSLY2 equation: [c] : pdx5p + selcys --> ala-L + h + pydx5p + seln R_SELCYSLY subsystem: Selenoamino acid metabolism R_SELCYSLY equation: [c] : dtt + selcys --> ala-L + dttOX + h + seln

409289
type: SpeciesReference
stoichiometry: 2.0
species: 318954

409205
type: SpeciesReference
stoichiometry: 1.0
species: 326530

326530
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyridoxine 5'-phosphate_C8H10NO6P

409253
type: SpeciesReference
stoichiometry: 2.0
species: 328725

328725
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Selenide_HSe

409277
type: SpeciesReference
stoichiometry: 1.0
species: 328001

328001
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyridoxal 5'-phosphate_C8H8NO6P

409229
type: SpeciesReference
stoichiometry: 1.0
species: 314900

314900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dithiothreitol_C4H10O2S2

409241
type: SpeciesReference
stoichiometry: 1.0
species: 314887

314887
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Oxidized dithiothreitol_C4H8O2S2

409217
type: SpeciesReference
stoichiometry: 2.0
species: 328677

328677
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Selenocysteine_C3H7NO2Se

409265
type: SpeciesReference
stoichiometry: 2.0
species: 309251

322033
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 9_C75H120N6O59S2X

313401
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: docosa-4,7,10,13,16-pentaenoyl carnitine_C29H47NO4

315720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Flavin adenine dinucleotide oxidized_C27H31N9O15P2

967315
type: Reaction
reactant: 336570
product: 336606
product: 336594
is: ENSRNOG00000004381.4
is: http://identifiers.org/ec-code/2.7.1.26
notes: R_RBFK subsystem: Riboflavin Metabolism R_RBFK equation: [c] : atp + ribflv --> adp + fmn + h
name: riboflavin kinase
fast: false
product: 336618
reactant: 336582
is: ENSRNOG00000029140.1
is: ENSRNOG00000002321.4
is: ENSRNOG00000022273.3
reversible: false

336570
type: SpeciesReference
stoichiometry: 1.0
species: 328364

328364
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Riboflavin_C17H20N4O6

336606
type: SpeciesReference
stoichiometry: 1.0
species: 315949

315949
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: FMN_C17H19N4O9P

336594
type: SpeciesReference
stoichiometry: 1.0
species: 308621

336618
type: SpeciesReference
stoichiometry: 1.0
species: 318954

336582
type: SpeciesReference
stoichiometry: 1.0
species: 310142

329450
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: triacylglycerol (homo sapiens)_C3H5FULLRCO2FULLR2CO2FULLR3CO2

328400
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: PA6_C90H145N6O65X

325259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Norepinephrine_C8H12NO3

321053
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 28_C104H170N7O85S3

307921
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Acetone_C3H6O

315432
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: estriol_C18H24O3

970655
type: Reaction
product: 366490
reactant: 366478
notes: R_MACACI subsystem: Tyrosine metabolism R_MACACI equation: [c] : 4mlacac --> 4fumacac
is: ENSRNOG00000013734.3
is: http://identifiers.org/ec-code/5.2.1.2
fast: false
reversible: false
name: maleylacetoacetate isomerase

366490
type: SpeciesReference
stoichiometry: 1.0
species: 305752

305752
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Fumarylacetoacetate_C8H6O6

366478
type: SpeciesReference
stoichiometry: 1.0
species: 305889

305889
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Maleylacetoacetate_C8H6O6

971888
type: Reaction
is: ENSRNOG00000002616.4
is: ENSRNOG00000001298.4
notes: R_INSTt4_2 subsystem: Transport, Extracellular R_INSTt4_2 equation: inost[e] + (2) na1[e] <==> inost[c] + (2) na1[c]
is: ENSRNOG00000013407.4
reactant: 379407
is: ENSRNOG00000027076.3
is: ENSRNOG00000006786.4
reactant: 379419
product: 379443
fast: false
name: inositol transport via sodium symport
reversible: true
product: 379431

379407
type: SpeciesReference
stoichiometry: 2.0
species: 324628

379419
type: SpeciesReference
stoichiometry: 1.0
species: 320596

320596
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: myo-Inositol_C6H12O6

379443
type: SpeciesReference
stoichiometry: 1.0
species: 320584

379431
type: SpeciesReference
stoichiometry: 2.0
species: 324616

311303
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Cholesterol_C27H46O

323539
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: monoacylglycerol 2 (homo sapiens)_C3H7O2FULLR2CO2

325914
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Ornithine_C5H13N2O2

974566
type: Reaction
reversible: false
is: ENSRNOG00000005260.4
reactant: 406396
product: 406432
product: 406420
name: acid phosphatase (FMN)
fast: false
is: ENSRNOG00000030819.2
reactant: 406408
is: http://identifiers.org/ec-code/3.1.3.2
notes: R_ACP1_LPAREN_FMN_RPAREN_ subsystem: Riboflavin Metabolism R_ACP1_LPAREN_FMN_RPAREN_ equation: [c] : fmn + h2o --> pi + ribflv

406396
type: SpeciesReference
stoichiometry: 1.0
species: 315949

406432
type: SpeciesReference
stoichiometry: 1.0
species: 326891

406420
type: SpeciesReference
stoichiometry: 1.0
species: 328364

406408
type: SpeciesReference
stoichiometry: 1.0
species: 318846

306415
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _5-Hydroxyindoleacetate_C10H8NO3

324411
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human liver homolog_C1300H2128N20O220P20

323131
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human liver homolog_C1360H2228N20O270P20

311905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Core 6_C16H27N2O10X

974999
type: Reaction
product: 409782
reversible: false
reactant: 409746
product: 409818
reactant: 409698
is: ENSRNOG00000002115.4
reactant: 409722
product: 409794
reactant: 409758
reactant: 409734
reactant: 409710
is: http://identifiers.org/ec-code/1.15.1.1
product: 409806
product: 409770
product: 409830
notes: R_SPODMn subsystem: ROS Detoxification R_SPODMn equation: [n] : (2) h + (2) o2s --> h2o2 + o2 R_SPODMx subsystem: ROS Detoxification R_SPODMx equation: [x] : (2) h + (2) o2s --> h2o2 + o2 R_SPODM subsystem: ROS Detoxification R_SPODM equation: [c] : (2) h + (2) o2s --> h2o2 + o2
fast: false

409782
type: SpeciesReference
stoichiometry: 1.0
species: 318822

318822
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Hydrogen peroxide_H2O2

409746
type: SpeciesReference
stoichiometry: 2.0
species: 319038

409818
type: SpeciesReference
stoichiometry: 1.0
species: 318774

318774
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hydrogen peroxide_H2O2

409698
type: SpeciesReference
stoichiometry: 2.0
species: 325500

325500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Superoxide anion_O2

409722
type: SpeciesReference
stoichiometry: 2.0
species: 319014

409794
type: SpeciesReference
stoichiometry: 1.0
species: 325428

325428
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: O2_O2

409758
type: SpeciesReference
stoichiometry: 2.0
species: 318954

409734
type: SpeciesReference
stoichiometry: 2.0
species: 325464

325464
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Superoxide anion_O2

409710
type: SpeciesReference
stoichiometry: 2.0
species: 325513

325513
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Superoxide anion_O2

409806
type: SpeciesReference
stoichiometry: 1.0
species: 318834

318834
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Hydrogen peroxide_H2O2

409770
type: SpeciesReference
stoichiometry: 1.0
species: 325452

325452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: O2_O2

409830
type: SpeciesReference
stoichiometry: 1.0
species: 325392

968999
type: Reaction
product: 352228
reactant: 352216
notes: R_GLBRAN subsystem: Starch and Sucrose Metabolism R_GLBRAN equation: [c] : glygn1 --> glygn2
is: ENSRNOG00000031531.2
is: http://identifiers.org/ec-code/2.4.1.18
fast: false
reversible: false
name: _1,4-alpha-glucan branching enzyme (glygn1 -> glygn2)

352228
type: SpeciesReference
stoichiometry: 1.0
species: 318100

318100
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: glycogen, structure 2 (glycogenin-1,6-{7[1,4-Glc], 4[1,4-Glc]})_C66H111O56X

352216
type: SpeciesReference
stoichiometry: 1.0
species: 318088

319446
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Histidine_C6H9N3O2

308985
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: S-Adenosyl-L-homocysteine_C14H20N6O5S

329208
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: stearoylcarnitine_C25H49NO4

322471
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Leucine_C6H13NO2

327881
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pentadecanoate_C15H29O2

318786
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Hydrogen peroxide_H2O2

976451
type: Reaction
product: 422506
modifier: 422604
modifier: 422580
is: ENSRNOG00000021663.2
reactant: 422397
modifier: 422543
modifier: 422568
reactant: 422422
is: http://identifiers.org/ec-code/1.1.1.78
modifier: 422592
is: http://identifiers.org/ec-code/1.2.1.49
modifier: 422555
product: 422518
product: 422458
reactant: 422446
product: 422470
notes: R_ALCD22_D subsystem: Pyruvate Metabolism R_ALCD22_D equation: [c] : lald-D + nad --> h + mthgxl + nadh R_34DHOXPEGOX subsystem: Tyrosine metabolism R_34DHOXPEGOX equation: [c] : 34dhmald + h + nadh <==> 34dhoxpeg + nad R_ALCD1 subsystem: Miscellaneous R_ALCD1 equation: [c] : meoh + nad <==> fald + h + nadh R_ALCD2if subsystem: Glycolysis/Gluconeogenesis R_ALCD2if equation: [c] : etoh + nad --> acald + h + nadh R_ALCD21_D subsystem: Pyruvate Metabolism R_ALCD21_D equation: [c] : 12ppd-R + nad --> h + lald-D + nadh R_ALCD22_L subsystem: Pyruvate Metabolism R_ALCD22_L equation: [c] : lald-L + nad --> h + mthgxl + nadh R_ALCD21_L subsystem: Pyruvate Metabolism R_ALCD21_L equation: [c] : 12ppd-S + nad --> h + lald-L + nadh
product: 422494
reactant: 422385
modifier: 422531
product: 422482
reversible: false
fast: false
is: ENSRNOG00000032959.2
is: ENSRNOG00000012464.3
is: http://identifiers.org/ec-code/1.1.1.1
reactant: 422434
is: ENSRNOG00000012436.4
reactant: 422409

422506
type: SpeciesReference
stoichiometry: 5.0
species: 318954

422397
type: SpeciesReference
stoichiometry: 1.0
species: 322386

323878
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Methanol_CH4O1

315816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Formaldehyde_CH2O

422422
type: SpeciesReference
stoichiometry: 5.0
species: 324676

422518
type: SpeciesReference
stoichiometry: 5.0
species: 324749

422458
type: SpeciesReference
stoichiometry: 2.0
species: 324447

422446
type: SpeciesReference
stoichiometry: 1.0
species: 322361

422470
type: SpeciesReference
stoichiometry: 1.0
species: 322386

422494
type: SpeciesReference
stoichiometry: 1.0
species: 322361

422385
type: SpeciesReference
stoichiometry: 1.0
species: 304148

304148
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (S)-Propane-1,2-diol_C3H8O2

304809
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3,4-Dihydroxyphenylethyleneglycol_C8H10O4

422482
type: SpeciesReference
stoichiometry: 1.0
species: 307777

422434
type: SpeciesReference
stoichiometry: 1.0
species: 315636

315636
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Ethanol_C2H6O

422409
type: SpeciesReference
stoichiometry: 1.0
species: 304136

304136
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (R)-Propane-1,2-diol_C3H8O2

969311
type: Reaction
product: 355105
notes: R_SERPT subsystem: Sphingolipid Metabolism R_SERPT equation: [c] : h + pmtcoa + ser-L --> 3dsphgn + co2 + coa
reactant: 355045
is: ENSRNOG00000012210.3
is: http://identifiers.org/ec-code/2.3.1.50
name: serine C-palmitoyltransferase
is: ENSRNOG00000010882.3
product: 355081
reversible: false
product: 355093
fast: false
reactant: 355069
reactant: 355057

355105
type: SpeciesReference
stoichiometry: 1.0
species: 305025

355045
type: SpeciesReference
stoichiometry: 1.0
species: 328773

355081
type: SpeciesReference
stoichiometry: 1.0
species: 311759

355093
type: SpeciesReference
stoichiometry: 1.0
species: 311681

355069
type: SpeciesReference
stoichiometry: 1.0
species: 318954

355057
type: SpeciesReference
stoichiometry: 1.0
species: 326987

329414
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

319206
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Hexadecanoate (n-C16:0)_C16H31O2

306197
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _5alpha-Dihydrotestosterone glucuronide_C25H38O8

328689
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Selenocystathionine_C7H14N2O4Se

316564
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glucosyl-(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)_C70H117N2O55X

312375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 1_C45H68N2O43S2

310806
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Carbamoyl-L-aspartate_C5H6N2O5

304977
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: _3'-AMP_C10H12N5O7P

977075
type: Reaction
reactant: 430528
reactant: 430468
notes: R_FATP9t subsystem: Transport, Extracellular R_FATP9t equation: na1[c] + nrvnc[c] <==> na1[e] + nrvnc[e] R_FATP7t subsystem: Transport, Extracellular R_FATP7t equation: crvnc[c] + na1[c] <==> crvnc[e] + na1[e] R_FATP4t subsystem: Transport, Extracellular R_FATP4t equation: arach[c] + na1[c] <==> arach[e] + na1[e] R_FATP5t subsystem: Transport, Extracellular R_FATP5t equation: arachd[c] + na1[c] <==> arachd[e] + na1[e] R_FATP6t subsystem: Transport, Extracellular R_FATP6t equation: adrn[c] + na1[c] <==> adrn[e] + na1[e] R_FATP8t subsystem: Transport, Extracellular R_FATP8t equation: lgnc[c] + na1[c] <==> lgnc[e] + na1[e]
reversible: true
product: 430564
reactant: 430540
product: 430600
product: 430588
is: ENSRNOG00000019626.3
product: 430624
reactant: 430492
product: 430552
reactant: 430516
reactant: 430480
product: 430576
fast: false
reactant: 430504
product: 430612

430528
type: SpeciesReference
stoichiometry: 1.0
species: 308765

308765
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: adrenic acid_C22H35O2

430468
type: SpeciesReference
stoichiometry: 1.0
species: 309852

309852
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: arachidonic acid_C20H31O2

430564
type: SpeciesReference
stoichiometry: 1.0
species: 325295

430540
type: SpeciesReference
stoichiometry: 1.0
species: 312146

312146
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cervonic acid, C22:6 n-3_C22H31O2

430600
type: SpeciesReference
stoichiometry: 1.0
species: 308777

308777
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: adrenic acid_C22H35O2

430588
type: SpeciesReference
stoichiometry: 6.0
species: 324628

430624
type: SpeciesReference
stoichiometry: 1.0
species: 322627

322627
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: lignoceric acid_C24H47O2

430492
type: SpeciesReference
stoichiometry: 6.0
species: 324616

430552
type: SpeciesReference
stoichiometry: 1.0
species: 309864

309864
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: arachidonic acid_C20H31O2

430516
type: SpeciesReference
stoichiometry: 1.0
species: 325283

325283
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: nervonic acid_C24H45O2

430480
type: SpeciesReference
stoichiometry: 1.0
species: 322615

322615
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: lignoceric acid_C24H47O2

430576
type: SpeciesReference
stoichiometry: 1.0
species: 312158

430504
type: SpeciesReference
stoichiometry: 1.0
species: 309768

309768
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Arachidic acid_C20H39O2

430612
type: SpeciesReference
stoichiometry: 1.0
species: 309780

309780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Arachidic acid_C20H39O2

330634
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Thiosulfate_O3S2

306307
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: (R)-5-Diphosphomevalonate_C6H10O10P2

323914
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Metanephrine_C10H16NO3

973846
type: Reaction
product: 397775
reactant: 397688
is: http://identifiers.org/ec-code/1.2.1.3
product: 397788
reactant: 397639
reactant: 397603
product: 397801
is: ENSRNOG00000001344.4
reactant: 397591
reactant: 397579
reversible: false
reactant: 397652
product: 397762
is: http://identifiers.org/ec-code/1.2.1.21
product: 397828
reactant: 397676
notes: R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_BAMPPALDOXm subsystem: beta-Alanine metabolism R_BAMPPALDOXm equation: [m] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_ALDD2xm subsystem: Glycolysis/Gluconeogenesis R_ALDD2xm equation: [m] : acald + h2o + nad --> ac + (2) h + nadh R_NABTNOm subsystem: Arginine and Proline Metabolism R_NABTNOm equation: [m] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_PYLALDOXm subsystem: Limonene and pinene degradation R_PYLALDOXm equation: [m] : h2o + nad + pylald --> (2) h + nadh + peracd R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD_m subsystem: Histidine Metabolism R_IMACTD_m equation: [m] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD20xm subsystem: Tryptophan metabolism R_ALDD20xm equation: [m] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_5HOXINDACTOXm subsystem: Tryptophan metabolism R_5HOXINDACTOXm equation: [m] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_GLACOm subsystem: Ascorbate and Aldarate Metabolism R_GLACOm equation: [m] : glac + (2) h2o + nad --> glcr + (3) h + nadh
reactant: 397627
reactant: 397555
product: 397814
product: 397749
product: 397712
reactant: 397567
product: 397737
fast: false
product: 397725
product: 397865
is: ENSRNOG00000011497.3
product: 397853
product: 397841
reactant: 397664
reactant: 397700
reactant: 397615

397775
type: SpeciesReference
stoichiometry: 1.0
species: 320572

320572
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Indole-3-acetate_C10H8NO2

397688
type: SpeciesReference
stoichiometry: 11.0
species: 324700

397788
type: SpeciesReference
stoichiometry: 1.0
species: 326663

326663
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Perillic acid_C10H13O2

397639
type: SpeciesReference
stoichiometry: 1.0
species: 322373

322373
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: D-Lactaldehyde_C3H6O2

397603
type: SpeciesReference
stoichiometry: 1.0
species: 306391

306391
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _5-Hydroxyindoleacetaldehyde_C10H9NO2

397801
type: SpeciesReference
stoichiometry: 1.0
species: 309190

309190
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: beta-Alanine_C3H7NO2

397591
type: SpeciesReference
stoichiometry: 1.0
species: 324592

324592
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: N4-Acetylaminobutanal_C6H11NO2

397579
type: SpeciesReference
stoichiometry: 1.0
species: 307789

307789
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Acetaldehyde_C2H4O

397652
type: SpeciesReference
stoichiometry: 1.0
species: 317494

317494
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: D-glucurono-6,3-lactone_C6H8O6

397762
type: SpeciesReference
stoichiometry: 1.0
species: 307717

307717
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Acetate_C2H3O2

397828
type: SpeciesReference
stoichiometry: 1.0
species: 322349

397676
type: SpeciesReference
stoichiometry: 1.0
species: 322398

322398
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Lactaldehyde_C3H6O2

397627
type: SpeciesReference
stoichiometry: 1.0
species: 320368

320368
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Indole-3-acetaldehyde_C10H9NO

397555
type: SpeciesReference
stoichiometry: 1.0
species: 310251

310251
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: beta-Aminopropion aldehyde_C3H8NO

397814
type: SpeciesReference
stoichiometry: 1.0
species: 320500

320500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Imidazole-4-acetate_C5H5N2O2

397749
type: SpeciesReference
stoichiometry: 1.0
species: 322311

322311
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: D-Lactate_C3H5O3

397712
type: SpeciesReference
stoichiometry: 1.0
species: 305666

305666
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _4-Acetamidobutanoate_C6H10NO3

397567
type: SpeciesReference
stoichiometry: 12.0
species: 318894

397737
type: SpeciesReference
stoichiometry: 1.0
species: 306415

397725
type: SpeciesReference
stoichiometry: 1.0
species: 318064

318064
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Glycolate_C2H3O3

397865
type: SpeciesReference
stoichiometry: 11.0
species: 324761

397853
type: SpeciesReference
stoichiometry: 1.0
species: 317579

317579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: D-Glucarate_C6H8O8

397841
type: SpeciesReference
stoichiometry: 23.0
species: 319002

397664
type: SpeciesReference
stoichiometry: 1.0
species: 328049

328049
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Perillyl aldehyde_C10H14O

397700
type: SpeciesReference
stoichiometry: 1.0
species: 317192

317192
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Glycolaldehyde_C2H4O2

397615
type: SpeciesReference
stoichiometry: 1.0
species: 320524

320524
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Imidazole-4-acetaldehyde_C5H6N2O

972453
type: Reaction
reactant: 384725
reversible: false
modifier: 384978
product: 384810
modifier: 384930
is: ENSRNOG00000033854.2
notes: R_ALCD22_D subsystem: Pyruvate Metabolism R_ALCD22_D equation: [c] : lald-D + nad --> h + mthgxl + nadh R_34DHOXPEGOX subsystem: Tyrosine metabolism R_34DHOXPEGOX equation: [c] : 34dhmald + h + nadh <==> 34dhoxpeg + nad R_ALCD1 subsystem: Miscellaneous R_ALCD1 equation: [c] : meoh + nad <==> fald + h + nadh R_ALCD2if subsystem: Glycolysis/Gluconeogenesis R_ALCD2if equation: [c] : etoh + nad --> acald + h + nadh R_ALCD21_D subsystem: Pyruvate Metabolism R_ALCD21_D equation: [c] : 12ppd-R + nad --> h + lald-D + nadh R_ALCD22_L subsystem: Pyruvate Metabolism R_ALCD22_L equation: [c] : lald-L + nad --> h + mthgxl + nadh R_LALDO subsystem: Pyruvate Metabolism R_LALDO equation: [c] : gthrd + lald-D + nad <==> h + lgt-S + nadh R_ALCD21_L subsystem: Pyruvate Metabolism R_ALCD21_L equation: [c] : 12ppd-S + nad --> h + lald-L + nadh R_FALDH subsystem: Tyrosine metabolism R_FALDH equation: [c] : fald + gthrd + nad <==> Sfglutth + h + nadh
reactant: 384713
reactant: 384737
modifier: 384906
modifier: 384966
modifier: 384882
is: http://identifiers.org/ec-code/1.1.1.78
is: http://identifiers.org/ec-code/1.2.1.1
modifier: 384870
is: http://identifiers.org/ec-code/1.1.1.1
modifier: 384942
fast: false
modifier: 384858
modifier: 384918
product: 384846
reactant: 384749
product: 384834
modifier: 384954
product: 384798
product: 384822
modifier: 384894
product: 384785
is: http://identifiers.org/ec-code/1.2.1.49
reactant: 384773
reactant: 384761

384725
type: SpeciesReference
stoichiometry: 1.0
species: 322386

384810
type: SpeciesReference
stoichiometry: 1.0
species: 307777

384713
type: SpeciesReference
stoichiometry: 1.0
species: 304148

384737
type: SpeciesReference
stoichiometry: 1.0
species: 304136

307512
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: S-Formylglutathione_C11H16N3O7S

384846
type: SpeciesReference
stoichiometry: 5.0
species: 324749

384749
type: SpeciesReference
stoichiometry: 5.0
species: 324676

384834
type: SpeciesReference
stoichiometry: 5.0
species: 318954

384798
type: SpeciesReference
stoichiometry: 1.0
species: 322386

384822
type: SpeciesReference
stoichiometry: 1.0
species: 322361

384785
type: SpeciesReference
stoichiometry: 2.0
species: 324447

384773
type: SpeciesReference
stoichiometry: 1.0
species: 322361

384761
type: SpeciesReference
stoichiometry: 1.0
species: 315636

330862
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: UDP_C9H11N2O12P2

313788
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dGTP_C10H12N5O13P3

311460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cardiolipin (homo sapiens)_C9H16O9P2FULLRCO2FULLR2CO2FULLRCO2FULLR2CO2

977351
type: Reaction
name: histidine decarboxylase
is: ENSRNOG00000010262.3
fast: false
product: 432553
product: 432565
notes: R_HISDC subsystem: Histidine Metabolism R_HISDC equation: [c] : h + his-L --> co2 + hista
reversible: false
is: http://identifiers.org/ec-code/4.1.1.22
reactant: 432528
reactant: 432541

432553
type: SpeciesReference
stoichiometry: 1.0
species: 319470

319470
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Histamine_C5H10N3

432565
type: SpeciesReference
stoichiometry: 1.0
species: 311681

432528
type: SpeciesReference
stoichiometry: 1.0
species: 319446

432541
type: SpeciesReference
stoichiometry: 1.0
species: 318954

318003
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (S)-Glycerate_C3H5O4

311327
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cholesterol sulfate_C27H45O4S

971588
type: Reaction
product: 375439
product: 375378
product: 375536
reversible: false
reactant: 375100
product: 375488
reactant: 375088
is: http://identifiers.org/ec-code/1.3.99.3
reactant: 375076
product: 375402
reactant: 375317
reactant: 375184
reactant: 375148
reactant: 375353
reactant: 375028
product: 375512
product: 375464
reactant: 375136
reactant: 375341
reactant: 375064
reactant: 375305
reactant: 375172
reactant: 375232
reactant: 375160
reactant: 375124
reactant: 375112
product: 375414
reactant: 375220
reactant: 375293
product: 375366
product: 375524
product: 375476
product: 375500
reactant: 375052
reactant: 375329
reactant: 375016
reactant: 375268
reactant: 375196
reactant: 375281
reactant: 375004
is: ENSRNOG00000001177.4
reactant: 375256
is: http://identifiers.org/ec-code/1.3.99.2
product: 375452
notes: R_FAOXC183806m subsystem: Fatty acid oxidation R_FAOXC183806m equation: [m] : (5) coa + (5) h2o + lnlncgcoa + (5) nad + (2) o2 --> (5) accoa + (5) h + (2) h2o2 + (5) nadh + occoa R_FAOXC161802m subsystem: Fatty acid activation R_FAOXC161802m equation: [m] : (4) coa + (3) fad + (4) h2o + hdd2coa + (4) nad --> (4) accoa + (3) fadh2 + (4) h + (4) nadh + occoa R_FAOXC160 subsystem: Fatty acid oxidation R_FAOXC160 equation: [m] : (7) coa + (7) fad + (7) h2o + (7) nad + pmtcoa --> (8) accoa + (7) fadh2 + (7) h + (7) nadh R_FAOXC2031836m subsystem: Fatty acid oxidation R_FAOXC2031836m equation: [m] : coa + dlnlcgcoa + fad + h2o + nad --> accoa + fadh2 + h + lnlncgcoa + nadh R_FAOXC80 subsystem: Fatty acid oxidation R_FAOXC80 equation: [m] : (3) coa + (3) fad + (3) h2o + (3) nad + occoa --> (4) accoa + (3) fadh2 + (3) h + (3) nadh R_PPCOAOm subsystem: Propanoate Metabolism R_PPCOAOm equation: [m] : fad + ppcoa --> fadh2 + prpncoa R_FAOXC2251836m subsystem: Fatty acid oxidation R_FAOXC2251836m equation: [m] : (2) coa + dcsptn1coa + (2) h2o + (2) nad --> (2) accoa + (2) h + lnlncgcoa + (2) nadh R_FAOXC18280m subsystem: Fatty acid oxidation R_FAOXC18280m equation: [m] : (5) coa + (3) fad + (5) h2o + lneldccoa + (5) nad --> (5) accoa + (3) fadh2 + (5) h + (5) nadh + occoa R_FAOXC16180m subsystem: Fatty acid oxidation R_FAOXC16180m equation: [m] : (4) coa + (3) fad + (4) h2o + hdcoa + (4) nad --> (4) accoa + (3) fadh2 + (4) h + (4) nadh + occoa R_FAOXC2051843m subsystem: Fatty acid oxidation R_FAOXC2051843m equation: [m] : coa + h2o + nad + tmndnccoa --> accoa + h + nadh + strdnccoa R_FAOXC183803m subsystem: Fatty acid oxidation R_FAOXC183803m equation: [m] : (5) coa + (2) fad + (5) h2o + lnlncacoa + (5) nad --> (5) accoa + (2) fadh2 + (5) h + (5) nadh + occoa R_FAOXC2242046m subsystem: Fatty acid oxidation R_FAOXC2242046m equation: [m] : adrncoa + coa + fad + h2o + nad --> accoa + arachdcoa + fadh2 + h + nadh R_FAOXC200180m subsystem: Fatty acid oxidation R_FAOXC200180m equatio…
fast: false
reactant: 375040
reactant: 375208
product: 375426
reactant: 375244
product: 375390

375439
type: SpeciesReference
stoichiometry: 11.0
species: 325622

325622
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Octanoyl-CoA (n-C8:0CoA)_C29H46N7O17P3S

375378
type: SpeciesReference
stoichiometry: 1.0
species: 309900

309900
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: C20:4-CoA_C41H62N7O17P3S

375536
type: SpeciesReference
stoichiometry: 103.0
species: 324761

375100
type: SpeciesReference
stoichiometry: 1.0
species: 315239

315239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: eicosatetranoyl coenzyme A_C41H62N7O17P3S

375488
type: SpeciesReference
stoichiometry: 2.0
species: 330357

330357
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: timnodonyl coenzyme A_C41H60N7O17P3S

375088
type: SpeciesReference
stoichiometry: 1.0
species: 329269

329269
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: stearidonyl coenzyme A_C39H58N7O17P3S

375076
type: SpeciesReference
stoichiometry: 103.0
species: 318894

375402
type: SpeciesReference
stoichiometry: 69.0
species: 315780

315780
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2

375317
type: SpeciesReference
stoichiometry: 1.0
species: 322963

375184
type: SpeciesReference
stoichiometry: 1.0
species: 310504

375148
type: SpeciesReference
stoichiometry: 2.0
species: 310625

310625
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: cervonyl coenzyme A_C43H62N7O17P3S

375353
type: SpeciesReference
stoichiometry: 3.0
species: 325416

375028
type: SpeciesReference
stoichiometry: 1.0
species: 325767

375512
type: SpeciesReference
stoichiometry: 2.0
species: 322963

375464
type: SpeciesReference
stoichiometry: 108.0
species: 307849

375136
type: SpeciesReference
stoichiometry: 1.0
species: 325622

375341
type: SpeciesReference
stoichiometry: 103.0
species: 324700

375064
type: SpeciesReference
stoichiometry: 1.0
species: 319266

319266
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Hexadecenoyl-CoA (n-C16:1CoA)_C37H60N7O17P3S

375305
type: SpeciesReference
stoichiometry: 2.0
species: 313365

313365
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A_C43H64N7O17P3S

375172
type: SpeciesReference
stoichiometry: 1.0
species: 325791

325791
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Octadecenoyl-CoA (n-C18:1CoA)_C39H64N7O17P3S

375232
type: SpeciesReference
stoichiometry: 1.0
species: 327905

327905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: pentadecanoyl Coenzyme A_C36H60N7O17P3S

375160
type: SpeciesReference
stoichiometry: 1.0
species: 322903

322903
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: alpha-Linolenoyl-CoA_C39H60N7O17P3S

375124
type: SpeciesReference
stoichiometry: 1.0
species: 308813

308813
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: adrenyl coenzyme A_C43H66N7O17P3S

375112
type: SpeciesReference
stoichiometry: 1.0
species: 309804

309804
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: arachidyl coenzyme A_C41H70N7O17P3S

375414
type: SpeciesReference
stoichiometry: 2.0
species: 329269

375220
type: SpeciesReference
stoichiometry: 1.0
species: 330357

375293
type: SpeciesReference
stoichiometry: 1.0
species: 329629

329629
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Tetradecanoyl-CoA (n-C14:0CoA)_C35H58N7O17P3S

375366
type: SpeciesReference
stoichiometry: 1.0
species: 329172

329172
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Stearoyl-CoA (n-C18:0CoA)_C39H66N7O17P3S

375524
type: SpeciesReference
stoichiometry: 103.0
species: 319002

375476
type: SpeciesReference
stoichiometry: 3.0
species: 318810

375500
type: SpeciesReference
stoichiometry: 1.0
species: 327133

327133
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Propanoyl-CoA_C24H36N7O17P3S

375052
type: SpeciesReference
stoichiometry: 1.0
species: 314295

375329
type: SpeciesReference
stoichiometry: 69.0
species: 315732

315732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Flavin adenine dinucleotide oxidized_C27H31N9O15P2

375016
type: SpeciesReference
stoichiometry: 1.0
species: 309900

375268
type: SpeciesReference
stoichiometry: 1.0
species: 327133

375196
type: SpeciesReference
stoichiometry: 1.0
species: 319290

319290
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

375281
type: SpeciesReference
stoichiometry: 103.0
species: 311797

375004
type: SpeciesReference
stoichiometry: 1.0
species: 329172

375256
type: SpeciesReference
stoichiometry: 1.0
species: 322843

322843
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: linoleic coenzyme A_C39H62N7O17P3S

375452
type: SpeciesReference
stoichiometry: 1.0
species: 310215

375040
type: SpeciesReference
stoichiometry: 2.0
species: 326999

326999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Palmitoyl-CoA (n-C16:0CoA)_C37H62N7O17P3S

375208
type: SpeciesReference
stoichiometry: 1.0
species: 322783

322783
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: linoelaidyl coenzyme A_C39H62N7O17P3S

375426
type: SpeciesReference
stoichiometry: 1.0
species: 327796

375244
type: SpeciesReference
stoichiometry: 1.0
species: 331405

331405
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: vaccenyl coenzyme A_C39H64N7O17P3S

375390
type: SpeciesReference
stoichiometry: 1.0
species: 326999

306607
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: pentaglutamyl folate (THF)_C39H45N11O18

323299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1600H2628N20O470P20

327821
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Phospho-alpha-D-ribose 1-diphosphate_C5H8O14P3

970976
type: Reaction
product: 369324
reactant: 369288
product: 369348
reversible: false
notes: R_NADNe subsystem: NAD Metabolism R_NADNe equation: [e] : h2o + nad --> adprib + h + ncam R_ADPRIBt subsystem: Transport, Extracellular R_ADPRIBt equation: adprib[e] --> adprib[c] R_NADPNe subsystem: NAD Metabolism R_NADPNe equation: [e] : h2o + nadp --> adprbp + h + ncam
product: 369360
is: ENSRNOG00000003069.2
reactant: 369276
product: 369312
is: http://identifiers.org/ec-code/3.2.2.5
reactant: 369300
reactant: 369264
product: 369336
is: http://identifiers.org/ec-code/3.2.2.6
fast: false

369324
type: SpeciesReference
stoichiometry: 2.0
species: 318966

369288
type: SpeciesReference
stoichiometry: 1.0
species: 308741

308741
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: ADPribose_C15H21N5O14P2

369348
type: SpeciesReference
stoichiometry: 2.0
species: 324967

324967
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Nicotinamide_C6H6N2O

369360
type: SpeciesReference
stoichiometry: 1.0
species: 308717

308717
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: ADPribose 2'-phosphate_C15H20N5O17P3

369276
type: SpeciesReference
stoichiometry: 2.0
species: 318858

369312
type: SpeciesReference
stoichiometry: 1.0
species: 308729

308729
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: ADPribose_C15H21N5O14P2

369300
type: SpeciesReference
stoichiometry: 1.0
species: 324688

324688
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2

369264
type: SpeciesReference
stoichiometry: 1.0
species: 324809

324809
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3

369336
type: SpeciesReference
stoichiometry: 1.0
species: 308741

976799
type: Reaction
product: 425888
product: 425936
reactant: 425792
product: 425912
is: ENSRNOG00000010938.3
product: 425900
product: 425984
reactant: 425864
reactant: 425768
reactant: 425852
product: 425960
reactant: 425756
reactant: 425840
reactant: 425780
fast: false
product: 425972
product: 425948
product: 425924
reversible: true
reactant: 425828
reactant: 425816
product: 425876
notes: R_SERGLYexR subsystem: Transport, Extracellular R_SERGLYexR equation: gly[c] + ser-L[e] <==> gly[e] + ser-L[c] R_THRGLNexR subsystem: Transport, Extracellular R_THRGLNexR equation: gln-L[c] + thr-L[e] <==> gln-L[e] + thr-L[c] R_ALAGLYexR subsystem: Transport, Extracellular R_ALAGLYexR equation: ala-L[e] + gly[c] <==> ala-L[c] + gly[e] R_SERGLNexR subsystem: Transport, Extracellular R_SERGLNexR equation: gln-L[c] + ser-L[e] <==> gln-L[e] + ser-L[c] R_THRGLYexR subsystem: Transport, Extracellular R_THRGLYexR equation: gly[c] + thr-L[e] <==> gly[e] + thr-L[c] R_ALADGLNexR subsystem: Transport, Extracellular R_ALADGLNexR equation: ala-D[e] + gln-L[c] <==> ala-D[c] + gln-L[e] R_CYSGLUexR subsystem: Transport, Extracellular R_CYSGLUexR equation: cys-L[e] + gln-L[c] <==> cys-L[c] + gln-L[e] R_SERDGLNexR subsystem: Transport, Extracellular R_SERDGLNexR equation: gln-L[c] + ser-D[e] <==> gln-L[e] + ser-D[c] R_ALADGLYexR subsystem: Transport, Extracellular R_ALADGLYexR equation: ala-D[e] + gly[c] <==> ala-D[c] + gly[e] R_SERDGLYexR subsystem: Transport, Extracellular R_SERDGLYexR equation: gly[c] + ser-D[e] <==> gly[e] + ser-D[c] R_ALAGLNexR subsystem: Transport, Extracellular R_ALAGLNexR equation: ala-L[e] + gln-L[c] <==> ala-L[c] + gln-L[e] R_CYSGLYexR subsystem: Transport, Extracellular R_CYSGLYexR equation: cys-L[c] + gly[e] <==> cys-L[e] + gly[c]
reactant: 425804

425888
type: SpeciesReference
stoichiometry: 1.0
species: 312918

312918
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Cysteine_C3H7NO2S

425936
type: SpeciesReference
stoichiometry: 2.0
species: 330186

330186
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Threonine_C4H9NO3

425792
type: SpeciesReference
stoichiometry: 1.0
species: 312918

425912
type: SpeciesReference
stoichiometry: 1.0
species: 312930

312930
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Cysteine_C3H7NO2S

425900
type: SpeciesReference
stoichiometry: 2.0
species: 328773

425984
type: SpeciesReference
stoichiometry: 2.0
species: 309203

309203
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Alanine_C3H7NO2

425864
type: SpeciesReference
stoichiometry: 2.0
species: 328785

425768
type: SpeciesReference
stoichiometry: 2.0
species: 328761

328761
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Serine_C3H7NO3

425852
type: SpeciesReference
stoichiometry: 2.0
species: 330198

330198
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Threonine_C4H9NO3

425960
type: SpeciesReference
stoichiometry: 2.0
species: 328749

328749
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Serine_C3H7NO3

425756
type: SpeciesReference
stoichiometry: 2.0
species: 309215

309215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Alanine_C3H7NO2

425840
type: SpeciesReference
stoichiometry: 1.0
species: 317883

425780
type: SpeciesReference
stoichiometry: 5.0
species: 317871

425972
type: SpeciesReference
stoichiometry: 2.0
species: 309251

425948
type: SpeciesReference
stoichiometry: 6.0
species: 317630

425924
type: SpeciesReference
stoichiometry: 5.0
species: 317883

425828
type: SpeciesReference
stoichiometry: 6.0
species: 317617

425816
type: SpeciesReference
stoichiometry: 1.0
species: 312930

425876
type: SpeciesReference
stoichiometry: 1.0
species: 317871

425804
type: SpeciesReference
stoichiometry: 2.0
species: 309263

308006
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: N-Acetyl-D-galactosamine_C8H15NO6

319770
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 17_C43H65N2O48S4

975659
type: Reaction
reactant: 415754
is: ENSRNOG00000017601.4
reactant: 415778
product: 415802
is: http://identifiers.org/ec-code/1.3.99.5
product: 415814
reactant: 415766
reversible: false
product: 415790
notes: R_SR5ARr subsystem: Steroid Metabolism R_SR5ARr equation: [r] : h + nadph + tststerone --> 5adtststerone + nadp R_SR5AR2r subsystem: Steroid Metabolism R_SR5AR2r equation: [r] : andrstndn + h + nadph --> andrstandn + nadp
fast: false
reactant: 415742

415754
type: SpeciesReference
stoichiometry: 1.0
species: 330574

415778
type: SpeciesReference
stoichiometry: 2.0
species: 319026

415802
type: SpeciesReference
stoichiometry: 2.0
species: 324845

415814
type: SpeciesReference
stoichiometry: 1.0
species: 306161

306161
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _5alpha-Dihydrotestosterone_C19H30O2

415766
type: SpeciesReference
stoichiometry: 1.0
species: 309552

415790
type: SpeciesReference
stoichiometry: 1.0
species: 309540

309540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: androstanedione_C19H28O2

415742
type: SpeciesReference
stoichiometry: 2.0
species: 324905

317709
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: L-Glutamate_C5H8NO4

320680
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Isopentenyl diphosphate_C5H9O7P2

974794
type: Reaction
notes: R_HKt subsystem: Transport, Extracellular R_HKt equation: atp[c] + h2o[c] + k[e] --> adp[c] + h[e] + k[c] + pi[c]
reactant: 408398
is: http://identifiers.org/ec-code/3.6.3.10
name: H+/K+ gastric/non-gastric P-ATPase and ABC ATPase
reversible: false
product: 408446
fast: false
is: ENSRNOG00000020985.4
product: 408410
product: 408434
product: 408422
is: ENSRNOG00000018543.3
reactant: 408386
reactant: 408374

408398
type: SpeciesReference
stoichiometry: 1.0
species: 318846

408446
type: SpeciesReference
stoichiometry: 1.0
species: 308621

408410
type: SpeciesReference
stoichiometry: 1.0
species: 318966

408434
type: SpeciesReference
stoichiometry: 1.0
species: 326891

408422
type: SpeciesReference
stoichiometry: 1.0
species: 320764

408386
type: SpeciesReference
stoichiometry: 1.0
species: 310142

408374
type: SpeciesReference
stoichiometry: 1.0
species: 320776

330526
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Tryptophan_C11H12N2O2

329062
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO

323764
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Mannose_C6H12O6

313704
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dGMP_C10H12N5O7P

304268
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _17alpha-Hydroxyprogesterone_C21H30O3

970350
type: Reaction
reactant: 363560
reversible: false
is: http://identifiers.org/ec-code/2.3.2.4
fast: false
product: 363572
name: gamma-glutamylcyclotransferase
is: ENSRNOG00000034084.2
notes: R_GGLUCT subsystem: Glutathione Metabolism R_GGLUCT equation: gluala[e] --> 5oxpro[c] + ala-L[c]
is: ENSRNOG00000028843.2
product: 363584

363560
type: SpeciesReference
stoichiometry: 1.0
species: 317748

317748
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _5-L-Glutamyl-L-alanine_C8H13N2O5

363572
type: SpeciesReference
stoichiometry: 1.0
species: 306547

306547
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Oxoproline_C5H6NO3

363584
type: SpeciesReference
stoichiometry: 1.0
species: 309251

975371
type: Reaction
product: 413222
fast: false
reactant: 413186
product: 413234
reactant: 413138
product: 413258
reactant: 413150
product: 413246
product: 413198
reactant: 413174
reversible: false
product: 413210
is: ENSRNOG00000015393.4
notes: R_GLYVESSEC subsystem: Transport, Extracellular R_GLYVESSEC equation: atp[c] + (3) gly[c] + h2o[c] --> adp[c] + (3) gly[e] + h[c] + pi[c] R_BALAVECSEC subsystem: Transport, Extracellular R_BALAVECSEC equation: (3) ala-B[c] + atp[c] + h2o[c] --> adp[c] + (3) ala-B[e] + h[c] + pi[c] R_GABAVESSEC subsystem: Transport, Extracellular R_GABAVESSEC equation: (3) 4abut[c] + atp[c] + h2o[c] --> (3) 4abut[e] + adp[c] + h[c] + pi[c]
reactant: 413162

413222
type: SpeciesReference
stoichiometry: 3.0
species: 317883

413186
type: SpeciesReference
stoichiometry: 3.0
species: 309166

309166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: beta-Alanine_C3H7NO2

413234
type: SpeciesReference
stoichiometry: 3.0
species: 308621

413138
type: SpeciesReference
stoichiometry: 3.0
species: 305679

305679
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Aminobutanoate_C4H9NO2

413258
type: SpeciesReference
stoichiometry: 3.0
species: 318954

413150
type: SpeciesReference
stoichiometry: 3.0
species: 317871

413246
type: SpeciesReference
stoichiometry: 3.0
species: 305691

305691
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _4-Aminobutanoate_C4H9NO2

413198
type: SpeciesReference
stoichiometry: 3.0
species: 309178

309178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: beta-Alanine_C3H7NO2

413174
type: SpeciesReference
stoichiometry: 3.0
species: 318846

413210
type: SpeciesReference
stoichiometry: 3.0
species: 326891

413162
type: SpeciesReference
stoichiometry: 3.0
species: 310142

327362
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pregnenolone_C21H32O2

974230
type: Reaction
reactant: 402587
product: 402660
is: ENSRNOG00000013791.4
product: 402647
product: 402672
product: 402623
is: ENSRNOG00000004089.3
product: 402599
is: http://identifiers.org/ec-code/3.6.1.9
reactant: 402574
is: http://identifiers.org/ec-code/2.7.7.18
reactant: 402562
reactant: 402550
reactant: 402526
product: 402635
product: 402611
reactant: 402538
reversible: false
notes: R_UDPGP subsystem: Starch and Sucrose Metabolism R_UDPGP equation: [c] : h2o + udpg --> g1p + (2) h + ump R_NNAT subsystem: NAD Metabolism R_NNAT equation: [c] : atp + h + nicrnt --> dnad + ppi R_DNADDP subsystem: NAD Metabolism R_DNADDP equation: [c] : dnad + h2o --> amp + (2) h + nicrnt
fast: false

402587
type: SpeciesReference
stoichiometry: 1.0
species: 314476

314476
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deamino-NAD+_C21H24N6O15P2

402660
type: SpeciesReference
stoichiometry: 1.0
species: 314476

402647
type: SpeciesReference
stoichiometry: 4.0
species: 318954

402672
type: SpeciesReference
stoichiometry: 1.0
species: 327157

402623
type: SpeciesReference
stoichiometry: 1.0
species: 316612

316612
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glucose 1-phosphate_C6H11O9P

402599
type: SpeciesReference
stoichiometry: 1.0
species: 325076

325076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinate D-ribonucleotide_C11H12NO9P

402574
type: SpeciesReference
stoichiometry: 1.0
species: 318954

402562
type: SpeciesReference
stoichiometry: 2.0
species: 318846

402550
type: SpeciesReference
stoichiometry: 1.0
species: 310142

402526
type: SpeciesReference
stoichiometry: 1.0
species: 325076

402635
type: SpeciesReference
stoichiometry: 1.0
species: 309455

402611
type: SpeciesReference
stoichiometry: 1.0
species: 331091

331091
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UMP_C9H11N2O9P

402538
type: SpeciesReference
stoichiometry: 1.0
species: 330959

330959
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UDPglucose_C15H22N2O17P2

968421
type: Reaction
reactant: 347039
product: 347052
notes: R_DHORD9 subsystem: Pyrimidine Biosynthesis R_DHORD9 equation: dhor-S[c] + q10[m] --> orot[c] + q10h2[m]
fast: false
name: dihydoorotic acid dehydrogenase (quinone10)
reversible: false
is: ENSRNOG00000015063.3
reactant: 347027
product: 347064

347039
type: SpeciesReference
stoichiometry: 1.0
species: 328121

328121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Ubiquinone-10_C59H90O4

347052
type: SpeciesReference
stoichiometry: 1.0
species: 328145

328145
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Ubiquinol-10_C59H92O4

347027
type: SpeciesReference
stoichiometry: 1.0
species: 314114

314114
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (S)-Dihydroorotate_C5H5N2O4

347064
type: SpeciesReference
stoichiometry: 1.0
species: 325950

325950
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Orotate_C5H3N2O4

320452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Isoleucine_C6H13NO2

311533
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: clupanodonyl carnitine_C29H47NO4

968854
type: Reaction
is: ENSRNOG00000029084.1
reversible: false
reactant: 350865
is: ENSRNOG00000015025.4
is: ENSRNOG00000022026.2
product: 350877
is: ENSRNOG00000039980.1
is: ENSRNOG00000029569.2
fast: false
reactant: 350853
notes: R_ATPtm subsystem: Transport, Mitochondrial R_ATPtm equation: adp[c] + atp[m] --> adp[m] + atp[c]
is: ENSRNOG00000037471.1
is: ENSRNOG00000027267.3
product: 350889
name: ADP/ATP transporter, mitochondrial
is: ENSRNOG00000010830.2

350865
type: SpeciesReference
stoichiometry: 1.0
species: 310166

350877
type: SpeciesReference
stoichiometry: 1.0
species: 310142

350853
type: SpeciesReference
stoichiometry: 1.0
species: 308621

350889
type: SpeciesReference
stoichiometry: 1.0
species: 308645

308645
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: ADP_C10H12N5O10P2

304893
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3',5'-Cyclic GMP_C10H11N5O7P

330886
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: UDP_C9H11N2O12P2

974939
type: Reaction
fast: false
reactant: 409301
name: CMP-Sia Golgi transport via CMP antiport
product: 409325
is: ENSRNOG00000008908.3
product: 409337
reversible: true
notes: R_CMPACNAtg subsystem: Transport, Golgi Apparatus R_CMPACNAtg equation: cmp[g] + cmpacna[c] <==> cmp[c] + cmpacna[g]
reactant: 409313

409301
type: SpeciesReference
stoichiometry: 1.0
species: 311618

311618
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CMP-N-acetylneuraminate_C20H29N4O16P

409325
type: SpeciesReference
stoichiometry: 1.0
species: 311558

409337
type: SpeciesReference
stoichiometry: 1.0
species: 311630

409313
type: SpeciesReference
stoichiometry: 1.0
species: 311582

319734
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 14_C57H84N3O62S5

973546
type: Reaction
product: 394159
fast: false
product: 394279
modifier: 394451
modifier: 394341
reactant: 393989
product: 394316
reactant: 394098
product: 394303
reactant: 394073
is: http://identifiers.org/ec-code/6.2.1.7
product: 394183
is: http://identifiers.org/ec-code/6.2.1.3
reactant: 394061
reactant: 394110
product: 394243
product: 394219
modifier: 394402
notes: R_VLCSp subsystem: Bile Acid Biosynthesis R_VLCSp equation: [x] : atp + coa + thcholstoic --> amp + cholcoar + ppi R_VLCS2p subsystem: Bile Acid Biosynthesis R_VLCS2p equation: [x] : atp + coa + dhcholestanate --> amp + dhcholestancoa + ppi R_FATP9t subsystem: Transport, Extracellular R_FATP9t equation: na1[c] + nrvnc[c] <==> na1[e] + nrvnc[e] R_FATP7t subsystem: Transport, Extracellular R_FATP7t equation: crvnc[c] + na1[c] <==> crvnc[e] + na1[e] R_FACOAL191 subsystem: Fatty acid activation R_FACOAL191 equation: [c] : atp + coa + prist --> amp + ppi + pristcoa R_FACOAL206 subsystem: Fatty acid activation R_FACOAL206 equation: [c] : atp + coa + phyt <==> amp + phytcoa + ppi R_VLCSr subsystem: Bile Acid Biosynthesis R_VLCSr equation: [r] : atp + coa + thcholstoic --> amp + cholcoar + ppi R_CYTDt4 subsystem: Transport, Extracellular R_CYTDt4 equation: cytd[e] + na1[e] --> cytd[c] + na1[c] R_FATP6t subsystem: Transport, Extracellular R_FATP6t equation: adrn[c] + na1[c] <==> adrn[e] + na1[e] R_FATP8t subsystem: Transport, Extracellular R_FATP8t equation: lgnc[c] + na1[c] <==> lgnc[e] + na1[e] R_ADNt4 subsystem: Transport, Extracellular R_ADNt4 equation: adn[e] + na1[e] --> adn[c] + na1[c] R_URIt4 subsystem: Transport, Extracellular R_URIt4 equation: na1[e] + uri[e] --> na1[c] + uri[c] R_THMDt4 subsystem: Transport, Extracellular R_THMDt4 equation: na1[e] + thymd[e] --> na1[c] + thymd[c] R_VLCS2r subsystem: Bile Acid Biosynthesis R_VLCS2r equation: [r] : atp + coa + dhcholestanate --> amp + dhcholestancoa + ppi
reactant: 394049
reversible: false
modifier: 394499
modifier: 394487
product: 394328
product: 394147
reactant: 394086
modifier: 394377
modifier: 394523
product: 394255
modifier: 394438
modifier: 394511
product: 394267
reactant: 394013
reactant: 394037
modifier: 394426
product: 394195
reactant: 394135
product: 394231
reactant: 394001
reactant: 394025
product: 394291
is: ENSRNOG00000018940.2
reactant: 393977
product: 394171
reactant: 393965
modifier: 394475
modifier: 394414
product: 394207
reactant: 393953
modifier: 394365
reactant: 394123
modifier: 394463
modifier: 394390
modifier: 394353

394159
type: SpeciesReference
stoichiometry: 2.0
species: 327194

394279
type: SpeciesReference
stoichiometry: 1.0
species: 331272

393989
type: SpeciesReference
stoichiometry: 1.0
species: 313862

313862
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4

394316
type: SpeciesReference
stoichiometry: 1.0
species: 309455

394098
type: SpeciesReference
stoichiometry: 1.0
species: 330246

394303
type: SpeciesReference
stoichiometry: 2.0
species: 309516

309516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: AMP_C10H12N5O7P

394073
type: SpeciesReference
stoichiometry: 1.0
species: 331284

394183
type: SpeciesReference
stoichiometry: 1.0
species: 313886

313886
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775

394061
type: SpeciesReference
stoichiometry: 2.0
species: 310202

310202
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: ATP_C10H12N5O13P3

394110
type: SpeciesReference
stoichiometry: 1.0
species: 312990

394243
type: SpeciesReference
stoichiometry: 2.0
species: 327206

327206
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Diphosphate_HO7P2

394219
type: SpeciesReference
stoichiometry: 4.0
species: 324616

326843
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phytanic acid_C20H39O2

394049
type: SpeciesReference
stoichiometry: 4.0
species: 324628

394328
type: SpeciesReference
stoichiometry: 1.0
species: 327157

394147
type: SpeciesReference
stoichiometry: 1.0
species: 311182

311182
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847

394086
type: SpeciesReference
stoichiometry: 1.0
species: 327446

327446
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pristanic acid_C19H37O2

394255
type: SpeciesReference
stoichiometry: 1.0
species: 308561

326867
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phytanyl coa_C41H70N7O17P3S

394267
type: SpeciesReference
stoichiometry: 1.0
species: 313898

313898
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847

394013
type: SpeciesReference
stoichiometry: 2.0
species: 311833

394037
type: SpeciesReference
stoichiometry: 1.0
species: 310142

394195
type: SpeciesReference
stoichiometry: 1.0
species: 327494

327494
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pristanoyl coa_C40H68N7O17P3S

394135
type: SpeciesReference
stoichiometry: 2.0
species: 310190

310190
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ATP_C10H12N5O13P3

394231
type: SpeciesReference
stoichiometry: 1.0
species: 330234

394001
type: SpeciesReference
stoichiometry: 1.0
species: 313874

313874
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _3alpha,7alpha-Dihydroxy-5beta-cholestanate_C27H45O4

394025
type: SpeciesReference
stoichiometry: 2.0
species: 311821

311821
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Coenzyme A_C21H32N7O16P3S

394291
type: SpeciesReference
stoichiometry: 1.0
species: 311170

311170
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775

393977
type: SpeciesReference
stoichiometry: 1.0
species: 329992

329992
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5

394171
type: SpeciesReference
stoichiometry: 2.0
species: 309528

309528
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: AMP_C10H12N5O7P

393965
type: SpeciesReference
stoichiometry: 1.0
species: 330004

330004
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5

394207
type: SpeciesReference
stoichiometry: 1.0
species: 312978

393953
type: SpeciesReference
stoichiometry: 1.0
species: 311759

394123
type: SpeciesReference
stoichiometry: 1.0
species: 308573

972681
type: Reaction
is: ENSRNOG00000006096.3
reactant: 386703
reversible: false
fast: false
reactant: 386691
reactant: 386679
notes: R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c] R_CLHCOtex subsystem: Transport, Extracellular R_CLHCOtex equation: cl[e] + (2) hco3[c] --> cl[c] + (2) hco3[e]
is: ENSRNOG00000029514.2
is: ENSRNOG00000000512.4
product: 386727
product: 386715
product: 386739

386703
type: SpeciesReference
stoichiometry: 1.0
species: 311448

386691
type: SpeciesReference
stoichiometry: 1.0
species: 328905

328905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Sulfate_O4S

386679
type: SpeciesReference
stoichiometry: 4.0
species: 319110

386727
type: SpeciesReference
stoichiometry: 1.0
species: 328893

328893
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sulfate_O4S

386715
type: SpeciesReference
stoichiometry: 1.0
species: 311436

386739
type: SpeciesReference
stoichiometry: 4.0
species: 319122

976967
type: Reaction
is: http://identifiers.org/ec-code/2.5.1.21
reactant: 429272
reversible: false
product: 429320
is: ENSRNOG00000021314.2
reactant: 429260
product: 429296
reactant: 429284
name: Squalene synthase
notes: R_SQLSr subsystem: Cholesterol Metabolism R_SQLSr equation: [r] : (2) frdp + h + nadph --> nadp + (2) ppi + sql
product: 429308
fast: false

429272
type: SpeciesReference
stoichiometry: 1.0
species: 324905

429320
type: SpeciesReference
stoichiometry: 1.0
species: 324845

429260
type: SpeciesReference
stoichiometry: 2.0
species: 316141

316141
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Farnesyl diphosphate_C15H25O7P2

429296
type: SpeciesReference
stoichiometry: 2.0
species: 327194

429284
type: SpeciesReference
stoichiometry: 1.0
species: 319026

429308
type: SpeciesReference
stoichiometry: 1.0
species: 329123

329123
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Squalene_C30H50

967736
type: Reaction
notes: R_UAG2EMAi subsystem: Aminosugar Metabolism R_UAG2EMAi equation: [c] : h2o + uacgam --> acmana + h + udp R_AMANK subsystem: Aminosugar Metabolism R_AMANK equation: [c] : acmana + atp --> acmanap + adp + h
product: 340429
product: 340417
reactant: 340393
fast: false
product: 340453
is: ENSRNOG00000014365.4
reactant: 340381
is: http://identifiers.org/ec-code/2.7.1.60
reversible: false
product: 340405
is: http://identifiers.org/ec-code/5.1.3.14
reactant: 340357
reactant: 340369
product: 340441

340429
type: SpeciesReference
stoichiometry: 1.0
species: 330826

330826
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UDP_C9H11N2O12P2

340417
type: SpeciesReference
stoichiometry: 1.0
species: 308621

340393
type: SpeciesReference
stoichiometry: 1.0
species: 318846

340453
type: SpeciesReference
stoichiometry: 2.0
species: 318954

340381
type: SpeciesReference
stoichiometry: 1.0
species: 310142

340405
type: SpeciesReference
stoichiometry: 1.0
species: 308283

308283
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetyl-D-mannosamine 6-phosphate_C8H14NO9P

340357
type: SpeciesReference
stoichiometry: 1.0
species: 330802

330802
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763

340369
type: SpeciesReference
stoichiometry: 1.0
species: 308271

308271
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetyl-D-mannosamine_C8H15NO6

340441
type: SpeciesReference
stoichiometry: 1.0
species: 308271

313922
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847

311085
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Choline_C5H14NO

973173
type: Reaction
product: 390529
product: 390505
product: 390469
reversible: false
product: 390517
reactant: 390445
fast: false
reactant: 390457
notes: R_PNTK subsystem: CoA Biosynthesis R_PNTK equation: [c] : atp + pnto-R --> 4ppan + adp + h R_PNTKm subsystem: CoA Biosynthesis R_PNTKm equation: [m] : atp + pnto-R --> 4ppan + adp + h
product: 390493
is: ENSRNOG00000025286.3
is: http://identifiers.org/ec-code/2.7.1.33
reactant: 390433
product: 390481
reactant: 390421

390529
type: SpeciesReference
stoichiometry: 1.0
species: 318954

390505
type: SpeciesReference
stoichiometry: 1.0
species: 306003

306003
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-4'-Phosphopantothenate_C9H15NO8P

390469
type: SpeciesReference
stoichiometry: 1.0
species: 306015

306015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: D-4'-Phosphopantothenate_C9H15NO8P

390517
type: SpeciesReference
stoichiometry: 1.0
species: 319002

390445
type: SpeciesReference
stoichiometry: 1.0
species: 327072

327072
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: (R)-Pantothenate_C9H16NO5

390457
type: SpeciesReference
stoichiometry: 1.0
species: 310166

390493
type: SpeciesReference
stoichiometry: 1.0
species: 308621

390433
type: SpeciesReference
stoichiometry: 1.0
species: 310142

390481
type: SpeciesReference
stoichiometry: 1.0
species: 308645

390421
type: SpeciesReference
stoichiometry: 1.0
species: 327048

970460
type: Reaction
is: http://identifiers.org/ec-code/1.1.1.49
reversible: true
name: glucose 6-phosphate dehydrogenase
fast: false
reactant: 364150
product: 364186
product: 364162
notes: R_G6PDH2r subsystem: Pentose Phosphate Pathway R_G6PDH2r equation: [c] : g6p + nadp <==> 6pgl + h + nadph
is: ENSRNOG00000037254.1
reactant: 364138
is: ENSRNOG00000037830.1
product: 364174

364150
type: SpeciesReference
stoichiometry: 1.0
species: 324797

364186
type: SpeciesReference
stoichiometry: 1.0
species: 324869

364162
type: SpeciesReference
stoichiometry: 1.0
species: 318954

364138
type: SpeciesReference
stoichiometry: 1.0
species: 316720

316720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glucose 6-phosphate_C6H11O9P

364174
type: SpeciesReference
stoichiometry: 1.0
species: 306715

306715
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _6-phospho-D-glucono-1,5-lactone_C6H9O9P

306811
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _7-Dehydrocholesterol_C27H44O

329884
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S

975707
type: Reaction
product: 416228
reactant: 416215
name: inositol transport in via proton symport
reversible: true
notes: R_INSTt2r subsystem: Transport, Extracellular R_INSTt2r equation: h[e] + inost[e] <==> h[c] + inost[c]
fast: false
reactant: 416203
is: ENSRNOG00000015741.2
product: 416240

416228
type: SpeciesReference
stoichiometry: 1.0
species: 320584

416215
type: SpeciesReference
stoichiometry: 1.0
species: 320596

416203
type: SpeciesReference
stoichiometry: 1.0
species: 318966

416240
type: SpeciesReference
stoichiometry: 1.0
species: 318954

322759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: linoelaidic acid (all trans C18:2)_C18H31O2

971912
type: Reaction
is: http://identifiers.org/ec-code/3.1.3.46
fast: false
reversible: false
is: ENSRNOG00000017637.3
is: http://identifiers.org/ec-code/3.1.3.11
product: 379551
is: ENSRNOG00000017597.3
reactant: 379539
notes: R_FBP26 subsystem: Fructose and Mannose Metabolism R_FBP26 equation: [c] : f26bp + h2o --> f6p + pi R_FBP subsystem: Glycolysis/Gluconeogenesis R_FBP equation: [c] : fdp + h2o --> f6p + pi
reactant: 379515
reactant: 379527
product: 379563

379551
type: SpeciesReference
stoichiometry: 2.0
species: 326891

379539
type: SpeciesReference
stoichiometry: 2.0
species: 318846

379515
type: SpeciesReference
stoichiometry: 1.0
species: 315684

315684
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Fructose 2,6-bisphosphate_C6H10O12P2

379527
type: SpeciesReference
stoichiometry: 1.0
species: 315865

315865
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Fructose 1,6-bisphosphate_C6H10O12P2

379563
type: SpeciesReference
stoichiometry: 2.0
species: 315708

975887
type: Reaction
notes: R_CH25H subsystem: Bile Acid Biosynthesis R_CH25H equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol25oh
is: ENSRNOG00000010076.3
product: 417598
reactant: 417550
product: 417586
reversible: false
fast: false
reactant: 417574
name: cholesterol 25-hydroxylase
reactant: 417538
product: 417610
reactant: 417562

417598
type: SpeciesReference
stoichiometry: 1.0
species: 331610

331610
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _25-Hydroxycholesterol_C27H46O2

417550
type: SpeciesReference
stoichiometry: 1.0
species: 311315

311315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Cholesterol_C27H46O

417586
type: SpeciesReference
stoichiometry: 1.0
species: 318918

318918
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: H2O_H2O

417574
type: SpeciesReference
stoichiometry: 1.0
species: 319026

417538
type: SpeciesReference
stoichiometry: 1.0
species: 325440

325440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: O2_O2

417610
type: SpeciesReference
stoichiometry: 1.0
species: 324845

417562
type: SpeciesReference
stoichiometry: 1.0
species: 324905

320344
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Isocitrate_C6H5O7

312772
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Cytosine_C4H5N3O

967664
type: Reaction
reactant: 339486
reactant: 339438
reactant: 339450
product: 339534
product: 339522
reactant: 339462
is: ENSRNOG00000015325.2
reactant: 339414
reversible: false
notes: R_M4BET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BET2er equation: [r] : mem2emgacpail_hs + pe_hs --> dag_hs + m(em)3gacpail_hs R_H6ET3er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6ET3er equation: [r] : m2emgacpail_hs + pe_hs --> dag_hs + em2emgacpail_hs R_H6_APOS_ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6_APOS_ET2er equation: [r] : em3gacpail_hs + pe_hs --> dag_hs + emem2gacpail_hs R_H7ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7ET2er equation: [r] : em2emgacpail_hs + pe_hs --> dag_hs + gpi_hs R_H4ET3er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H4ET3er equation: [r] : m3gacpail_hs + pe_hs --> dag_hs + em3gacpail_hs R_M4CET3er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4CET3er equation: [r] : m3emgacpail_hs + pe_hs --> dag_hs + mem2emgacpail_hs
product: 339570
product: 339558
fast: false
reactant: 339426
product: 339546
reactant: 339474
product: 339510
product: 339498

339486
type: SpeciesReference
stoichiometry: 1.0
species: 315311

315311
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (phosphoethanolaminyl-dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (H7)_C53H100N3O35P3FULLRCO2FULLR2CO2

339438
type: SpeciesReference
stoichiometry: 1.0
species: 323155

323155
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (dimannosyl),(phosphoethanolaminyl)-mannosyl-glucosylaminyl-acylphosphatidylinositol (H6)_C51H94N2O32P2FULLRCO2FULLR2CO2

339450
type: SpeciesReference
stoichiometry: 1.0
species: 323215

323215
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: trimannosyl-glucosaminyl-acylphosphatidylinositol (H4)_C49H88NO29PFULLRCO2FULLR2CO2

339534
type: SpeciesReference
stoichiometry: 1.0
species: 323842

323842
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol (M4B)_C59H110N3O40P3FULLRCO2FULLR2CO2

339522
type: SpeciesReference
stoichiometry: 6.0
species: 313146

313146
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: diacylglycerol (homo sapiens)_C3H6OFULLRCO2FULLR2CO2

339462
type: SpeciesReference
stoichiometry: 1.0
species: 323842

339414
type: SpeciesReference
stoichiometry: 1.0
species: 315336

315336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphoethanolaminyl-trimannosyl-glucosaminyl-acylphosphatidylinositol (H6')_C51H94N2O32P2FULLRCO2FULLR2CO2

339570
type: SpeciesReference
stoichiometry: 1.0
species: 315311

339558
type: SpeciesReference
stoichiometry: 1.0
species: 323515

323515
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol (M4A)_C61H116N4O43P4FULLRCO2FULLR2CO2

339426
type: SpeciesReference
stoichiometry: 6.0
species: 326578

326578
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2

339546
type: SpeciesReference
stoichiometry: 1.0
species: 315348

315348
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (phosphoethanolaminyl-mannosyl),(phosphoethanolaminyl)-dimannosyl-glucosaminyl-acylphosphatidylinositol (H7')_C53H100N3O35P3FULLRCO2FULLR2CO2

339474
type: SpeciesReference
stoichiometry: 1.0
species: 323203

323203
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (trimannosyl),(phosphoethanolaminyl)-mannosyl-glucosaminyl-acylphosphatidylinositol (M4C)_C57H104N2O37P2FULLRCO2FULLR2CO2

339510
type: SpeciesReference
stoichiometry: 1.0
species: 318354

318354
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glycophosphatidylinositol (GPI) anchor precursor (3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol) (H8)_C55H106N4O38P4FULLRCO2FULLR2CO2

339498
type: SpeciesReference
stoichiometry: 1.0
species: 315336

319506
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763

967230
type: Reaction
reversible: true
product: 336013
reactant: 335977
fast: false
notes: R_MDHm subsystem: Citric Acid Cycle R_MDHm equation: [m] : mal-L + nad <==> h + nadh + oaa R_SLDxm subsystem: Cysteine Metabolism R_SLDxm equation: [m] : nad + sl-L <==> 3spyr + h + nadh
reactant: 335965
is: ENSRNOG00000005498.2
product: 336001
product: 336025
is: http://identifiers.org/ec-code/1.1.1.37
reactant: 335952
is: http://identifiers.org/ec-code/1.1.1.272
product: 335989

336013
type: SpeciesReference
stoichiometry: 2.0
species: 319002

335977
type: SpeciesReference
stoichiometry: 1.0
species: 323600

335965
type: SpeciesReference
stoichiometry: 2.0
species: 324700

336001
type: SpeciesReference
stoichiometry: 1.0
species: 325537

325537
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Oxaloacetate_C4H2O5

336025
type: SpeciesReference
stoichiometry: 2.0
species: 324761

335952
type: SpeciesReference
stoichiometry: 1.0
species: 328857

335989
type: SpeciesReference
stoichiometry: 1.0
species: 305557

305557
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Sulfopyruvate_C3H2O6S

316975
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)6 (Glc)1 (GlcNAc)3 (LFuc)2 (Cer)1_C96H165N4O60FULLRCO

308911
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Agmatine_C5H16N4

970824
type: Reaction
product: 367955
reactant: 367906
is: ENSRNOG00000024410.3
is: ENSRNOG00000005639.4
notes: R_BILIRED subsystem: Heme Degradation R_BILIRED equation: [c] : biliverd + h + nadph --> bilirub + nadp
product: 367942
fast: false
name: Nad(p)h biliverdin reductase
is: http://identifiers.org/ec-code/1.3.1.24
is: ENSRNOG00000028467.3
reactant: 367930
reactant: 367918
reversible: false

367955
type: SpeciesReference
stoichiometry: 1.0
species: 324797

367906
type: SpeciesReference
stoichiometry: 1.0
species: 318954

367942
type: SpeciesReference
stoichiometry: 1.0
species: 310384

310384
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Bilirubin_C33H34N4O6

367930
type: SpeciesReference
stoichiometry: 1.0
species: 310420

310420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Biliverdin_C33H32N4O6

367918
type: SpeciesReference
stoichiometry: 1.0
species: 324869

303871
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _10-formyltetrahydrofolate-[Glu](5)_C40H45N11O19

974854
type: Reaction
product: 408795
is: ENSRNOG00000011630.4
reversible: true
is: http://identifiers.org/ec-code/2.7.4.3
reactant: 408771
name: adenylate kinase, mitochondrial
fast: false
is: ENSRNOG00000000122.2
is: ENSRNOG00000021489.3
reactant: 408783
notes: R_ADK1m subsystem: Nucleotides R_ADK1m equation: [m] : amp + atp <==> (2) adp

408795
type: SpeciesReference
stoichiometry: 2.0
species: 308645

408771
type: SpeciesReference
stoichiometry: 1.0
species: 309504

408783
type: SpeciesReference
stoichiometry: 1.0
species: 310166

313002
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Cytidine_C9H13N3O5

306703
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _6-Phospho-D-gluconate_C6H10O10P

312531
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 6_C23H35O27S2

969975
type: Reaction
fast: false
reactant: 360352
reactant: 360340
product: 360400
reactant: 360364
reactant: 360376
product: 360388
is: ENSRNOG00000018200.3
notes: R_3SALACBOXL subsystem: Taurine and hypotaurine metabolism R_3SALACBOXL equation: [c] : 3sala + h --> co2 + hyptaur R_GLUDC subsystem: Glutamate metabolism R_GLUDC equation: [c] : glu-L + h --> 4abut + co2 R_LCYSTCBOXL subsystem: Taurine and hypotaurine metabolism R_LCYSTCBOXL equation: [c] : Lcyst + h --> co2 + taur
is: http://identifiers.org/ec-code/4.1.1.15
product: 360412
product: 360424
reversible: false

360352
type: SpeciesReference
stoichiometry: 1.0
species: 305496

305496
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Sulfino-L-alanine_C3H5NO4S

360340
type: SpeciesReference
stoichiometry: 1.0
species: 307016

307016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Cysteate_C3H6NO5S

360400
type: SpeciesReference
stoichiometry: 1.0
species: 305679

360364
type: SpeciesReference
stoichiometry: 1.0
species: 317683

360376
type: SpeciesReference
stoichiometry: 3.0
species: 318954

360388
type: SpeciesReference
stoichiometry: 1.0
species: 329486

360412
type: SpeciesReference
stoichiometry: 1.0
species: 320271

320271
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hypotaurine_C2H6NO2S

360424
type: SpeciesReference
stoichiometry: 3.0
species: 311681

309672
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Holocarboxylase (biotin covalent bound to Lys residue of apoC)_C16H27N4O3SX

976739
type: Reaction
is: http://identifiers.org/ec-code/2.7.7.23
reactant: 425492
reversible: false
name: UDP-N-acetylglucosamine diphosphorylase
fast: false
is: ENSRNOG00000002926.3
product: 425516
is: ENSRNOG00000012960.4
product: 425504
notes: R_UAGDP subsystem: Aminosugar Metabolism R_UAGDP equation: [c] : acgam1p + h + utp --> ppi + uacgam
is: ENSRNOG00000031342.2
reactant: 425480
reactant: 425468

425492
type: SpeciesReference
stoichiometry: 1.0
species: 331332

331332
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UTP_C9H11N2O15P3

425516
type: SpeciesReference
stoichiometry: 1.0
species: 327157

425504
type: SpeciesReference
stoichiometry: 1.0
species: 330802

425480
type: SpeciesReference
stoichiometry: 1.0
species: 318954

425468
type: SpeciesReference
stoichiometry: 1.0
species: 308079

308079
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetyl-D-glucosamine 1-phosphate_C8H14NO9P

323083
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Lysine_C6H15N2O2

967904
type: Reaction
reactant: 341811
reversible: false
product: 341823
product: 341835
is: http://identifiers.org/ec-code/4.1.3.4
notes: R_HMGLm subsystem: Cholesterol Metabolism R_HMGLm equation: [m] : hmgcoa --> acac + accoa
is: ENSRNOG00000011193.3
name: hydroxymethylglutaryl-CoA lyase
fast: false

341811
type: SpeciesReference
stoichiometry: 1.0
species: 319518

341823
type: SpeciesReference
stoichiometry: 1.0
species: 307849

341835
type: SpeciesReference
stoichiometry: 1.0
species: 307753

969939
type: Reaction
fast: false
reactant: 360063
reactant: 360099
reactant: 360075
is: ENSRNOG00000036684.1
notes: R_PETHCT subsystem: Glycerophospholipid Metabolism R_PETHCT equation: [c] : ctp + ethamp + h --> cdpea + ppi R_EPCTX subsystem: Glycerophospholipid Metabolism R_EPCTX equation: [c] : 2ameph + ctp + h --> cmp2amep + ppi
is: http://identifiers.org/ec-code/2.7.7.14
product: 360135
product: 360111
reactant: 360087
reversible: false
product: 360123

360063
type: SpeciesReference
stoichiometry: 1.0
species: 304497

304497
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (2-Aminoethyl)phosphonate_C2H7NO3P

360099
type: SpeciesReference
stoichiometry: 2.0
species: 312857

312857
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CTP_C9H12N3O14P3

360075
type: SpeciesReference
stoichiometry: 1.0
species: 315612

315612
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Ethanolamine phosphate_C2H7NO4P

360135
type: SpeciesReference
stoichiometry: 2.0
species: 327157

360111
type: SpeciesReference
stoichiometry: 1.0
species: 310963

310963
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CDPethanolamine_C11H19N4O11P2

360087
type: SpeciesReference
stoichiometry: 2.0
species: 318954

360123
type: SpeciesReference
stoichiometry: 1.0
species: 311545

311545
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763

314814
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dTDP_C10H13N2O11P2

314536
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog_C1140H1868O90P10

973341
type: Reaction
product: 391989
reversible: true
reactant: 391965
product: 392001
reactant: 391977
fast: false
reactant: 391941
is: http://identifiers.org/ec-code/4.2.1.2
reactant: 391953
notes: R_FUM subsystem: Citric Acid Cycle R_FUM equation: [c] : fum + h2o <==> mal-L R_FUMm subsystem: Citric Acid Cycle R_FUMm equation: [m] : fum + h2o <==> mal-L
is: ENSRNOG00000003653.4

391989
type: SpeciesReference
stoichiometry: 1.0
species: 323600

391965
type: SpeciesReference
stoichiometry: 1.0
species: 316528

316528
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Fumarate_C4H2O4

392001
type: SpeciesReference
stoichiometry: 1.0
species: 323588

391977
type: SpeciesReference
stoichiometry: 1.0
species: 318846

391941
type: SpeciesReference
stoichiometry: 1.0
species: 318894

391953
type: SpeciesReference
stoichiometry: 1.0
species: 316516

316516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Fumarate_C4H2O4

971984
type: Reaction
product: 380024
reversible: true
product: 380036
is: http://identifiers.org/ec-code/2.3.1.9
is: ENSRNOG00000007862.3
product: 380012
notes: R_ACACT10m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ACACT10m equation: [m] : 2maacoa + coa <==> accoa + ppcoa R_ACACT1rm subsystem: Tryptophan metabolism R_ACACT1rm equation: [m] : (2) accoa <==> aacoa + coa
fast: false
reactant: 379976
reactant: 379988
reactant: 380000
product: 380048

380024
type: SpeciesReference
stoichiometry: 1.0
species: 307849

380036
type: SpeciesReference
stoichiometry: 1.0
species: 311797

380012
type: SpeciesReference
stoichiometry: 1.0
species: 307620

379976
type: SpeciesReference
stoichiometry: 2.0
species: 307849

379988
type: SpeciesReference
stoichiometry: 1.0
species: 304653

304653
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

380000
type: SpeciesReference
stoichiometry: 1.0
species: 311797

380048
type: SpeciesReference
stoichiometry: 1.0
species: 327133

311570
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: CMP_C9H12N3O8P

977195
type: Reaction
fast: false
product: 431610
product: 431586
is: ENSRNOG00000019604.3
product: 431598
name: choline phosphatase
reactant: 431562
notes: R_PCHOLP_hs subsystem: Glycerophospholipid Metabolism R_PCHOLP_hs equation: [c] : h2o + pchol_hs --> chol + h + pa_hs
reversible: false
reactant: 431574
is: http://identifiers.org/ec-code/3.1.4.4

431610
type: SpeciesReference
stoichiometry: 1.0
species: 318954

431586
type: SpeciesReference
stoichiometry: 1.0
species: 311036

311036
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Choline_C5H14NO

431598
type: SpeciesReference
stoichiometry: 1.0
species: 325998

325998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2

431562
type: SpeciesReference
stoichiometry: 1.0
species: 326397

431574
type: SpeciesReference
stoichiometry: 1.0
species: 318846

973774
type: Reaction
is: ENSRNOG00000002969.4
reversible: false
is: ENSRNOG00000005284.2
fast: false
notes: R_MI145PK subsystem: Inositol Phosphate Metabolism R_MI145PK equation: [c] : atp + mi145p --> adp + h + mi1345p
is: ENSRNOG00000013945.2
product: 396699
reactant: 396675
reactant: 396687
product: 396723
name: inositol-1,4,5-trisphosphate 3-kinase
product: 396711
is: http://identifiers.org/ec-code/2.7.1.127

396699
type: SpeciesReference
stoichiometry: 1.0
species: 324108

324108
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1,3,4,5-tetrakisphosphate_C6H8O18P4

396675
type: SpeciesReference
stoichiometry: 1.0
species: 310142

396687
type: SpeciesReference
stoichiometry: 1.0
species: 324168

396723
type: SpeciesReference
stoichiometry: 1.0
species: 318954

396711
type: SpeciesReference
stoichiometry: 1.0
species: 308621

304293
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _1-alpha,25-Dihydroxyvitamin D2_C28H44O3

305703
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: _4-Aminobutanoate_C4H9NO2

974266
type: Reaction
product: 403137
notes: R_CYTK5 subsystem: Nucleotides R_CYTK5 equation: [c] : ctp + dcmp <==> cdp + dcdp R_CYTK10n subsystem: Nucleotides R_CYTK10n equation: [n] : cmp + dgtp <==> cdp + dgdp R_CYTK6n subsystem: Nucleotides R_CYTK6n equation: [n] : cmp + ctp <==> (2) cdp R_CYTK6 subsystem: Nucleotides R_CYTK6 equation: [c] : cmp + ctp <==> (2) cdp R_UMPK5 subsystem: Nucleotides R_UMPK5 equation: [c] : datp + ump <==> dadp + udp R_CYTK11 subsystem: Nucleotides R_CYTK11 equation: [c] : dcmp + dgtp <==> dcdp + dgdp R_UMPK3n subsystem: Nucleotides R_UMPK3n equation: [n] : ump + utp <==> (2) udp R_UMPK6n subsystem: Nucleotides R_UMPK6n equation: [n] : dctp + ump <==> dcdp + udp R_CYTK14n subsystem: Nucleotides R_CYTK14n equation: [n] : dcmp + utp <==> dcdp + udp R_UMPK2 subsystem: Nucleotides R_UMPK2 equation: [c] : ctp + ump <==> cdp + udp R_CYTK2n subsystem: Nucleotides R_CYTK2n equation: [n] : atp + dcmp <==> adp + dcdp R_UMPK6 subsystem: Nucleotides R_UMPK6 equation: [c] : dctp + ump <==> dcdp + udp R_UMPK4 subsystem: Nucleotides R_UMPK4 equation: [c] : gtp + ump <==> gdp + udp R_CYTK2 subsystem: Nucleotides R_CYTK2 equation: [c] : atp + dcmp <==> adp + dcdp R_UMPK5n subsystem: Nucleotides R_UMPK5n equation: [n] : datp + ump <==> dadp + udp R_UMPK subsystem: Nucleotides R_UMPK equation: [c] : atp + ump <==> adp + udp R_CYTK13 subsystem: Nucleotides R_CYTK13 equation: [c] : datp + dcmp <==> dadp + dcdp R_CYTK13n subsystem: Nucleotides R_CYTK13n equation: [n] : datp + dcmp <==> dadp + dcdp R_UMPK2n subsystem: Nucleotides R_UMPK2n equation: [n] : ctp + ump <==> cdp + udp R_CYTK9n subsystem: Nucleotides R_CYTK9n equation: [n] : cmp + dctp <==> cdp + dcdp R_CYTK7n subsystem: Nucleotides R_CYTK7n equation: [n] : cmp + utp <==> cdp + udp R_CYTK7 subsystem: Nucleotides R_CYTK7 equation: [c] : cmp + utp <==> cdp + udp R_CYTK3n subsystem: Nucleotides R_CYTK3n equation: [n] : ctp + dcmp <==> cdp + dcdp R_CYTK1 subsystem: Nucleotides R_CYTK1 equation: [c] : atp + cmp <==> adp + cdp R_CYTK14 subsystem: …
product: 403100
product: 403173
is: ENSRNOG00000007775.4
reactant: 403039
reactant: 402882
reactant: 402943
reactant: 402894
reactant: 402907
reactant: 402870
reactant: 402858
reactant: 402931
fast: false
reversible: true
reactant: 402834
product: 403197
product: 403075
reactant: 402991
reactant: 402979
reactant: 402967
is: http://identifiers.org/ec-code/2.7.4.14
product: 403125
reactant: 402919
reactant: 402955
reactant: 403063
product: 403233
reactant: 403051
product: 403149
product: 403221
product: 403161
reactant: 402846
product: 403112
product: 403087
product: 403209
reactant: 403027
reactant: 403003
reactant: 403015
product: 403185

403137
type: SpeciesReference
stoichiometry: 3.0
species: 313098

313098
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dADP_C10H12N5O9P2

403100
type: SpeciesReference
stoichiometry: 3.0
species: 313074

313074
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dADP_C10H12N5O9P2

403173
type: SpeciesReference
stoichiometry: 3.0
species: 308657

308657
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: ADP_C10H12N5O10P2

403039
type: SpeciesReference
stoichiometry: 6.0
species: 313303

313303
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dCMP_C9H12N3O7P

402882
type: SpeciesReference
stoichiometry: 3.0
species: 312881

312881
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: CTP_C9H12N3O14P3

402943
type: SpeciesReference
stoichiometry: 3.0
species: 313206

313206
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dATP_C10H12N5O12P3

402894
type: SpeciesReference
stoichiometry: 3.0
species: 310142

402907
type: SpeciesReference
stoichiometry: 3.0
species: 331368

331368
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: UTP_C9H11N2O15P3

402870
type: SpeciesReference
stoichiometry: 7.0
species: 331091

402858
type: SpeciesReference
stoichiometry: 3.0
species: 313788

402931
type: SpeciesReference
stoichiometry: 3.0
species: 313437

313437
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dCTP_C9H12N3O13P3

402834
type: SpeciesReference
stoichiometry: 6.0
species: 311558

403197
type: SpeciesReference
stoichiometry: 9.0
species: 313255

313255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dCDP_C9H12N3O10P2

403075
type: SpeciesReference
stoichiometry: 3.0
species: 317397

317397
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: GDP_C10H12N5O11P2

402991
type: SpeciesReference
stoichiometry: 7.0
species: 331151

331151
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: UMP_C9H11N2O9P

402979
type: SpeciesReference
stoichiometry: 3.0
species: 310178

310178
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: ATP_C10H12N5O13P3

402967
type: SpeciesReference
stoichiometry: 3.0
species: 313764

313764
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dGTP_C10H12N5O13P3

403125
type: SpeciesReference
stoichiometry: 10.0
species: 330886

402919
type: SpeciesReference
stoichiometry: 3.0
species: 313182

313182
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dATP_C10H12N5O12P3

402955
type: SpeciesReference
stoichiometry: 1.0
species: 318666

318666
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: GTP_C10H12N5O14P3

403063
type: SpeciesReference
stoichiometry: 3.0
species: 312857

403233
type: SpeciesReference
stoichiometry: 9.0
species: 310890

310890
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: CDP_C9H12N3O11P2

403051
type: SpeciesReference
stoichiometry: 3.0
species: 331332

403149
type: SpeciesReference
stoichiometry: 3.0
species: 308621

403221
type: SpeciesReference
stoichiometry: 3.0
species: 313643

313643
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dGDP_C10H12N5O10P2

403161
type: SpeciesReference
stoichiometry: 10.0
species: 313279

313279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dCDP_C9H12N3O10P2

402846
type: SpeciesReference
stoichiometry: 7.0
species: 311606

311606
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: CMP_C9H12N3O8P

403112
type: SpeciesReference
stoichiometry: 10.0
species: 310914

310914
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: CDP_C9H12N3O11P2

403087
type: SpeciesReference
stoichiometry: 1.0
species: 317349

403209
type: SpeciesReference
stoichiometry: 3.0
species: 313667

313667
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dGDP_C10H12N5O10P2

403027
type: SpeciesReference
stoichiometry: 3.0
species: 313413

313413
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dCTP_C9H12N3O13P3

403003
type: SpeciesReference
stoichiometry: 3.0
species: 318702

403015
type: SpeciesReference
stoichiometry: 7.0
species: 313328

313328
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dCMP_C9H12N3O7P

403185
type: SpeciesReference
stoichiometry: 10.0
species: 330826

330730
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Thromboxane A2_C20H31O5

972909
type: Reaction
modifier: 388223
product: 388123
notes: R_RDH2a subsystem: Vitamin A Metabolism R_RDH2a equation: [c] : nadp + retinol-9-cis <==> h + nadph + retinal-cis-9 R_RDH3a subsystem: Vitamin A Metabolism R_RDH3a equation: [c] : nadp + retinol-cis-11 <==> h + nadph + retinal-11-cis R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal R_NTD11 subsystem: Purine Catabolism R_NTD11 equation: [c] : h2o + imp --> ins + pi R_NTD3 subsystem: Pyrimidine Catabolism R_NTD3 equation: [c] : dcmp + h2o --> dcyt + pi R_NTD7 subsystem: Nucleotides R_NTD7 equation: [c] : amp + h2o --> adn + pi
modifier: 388199
modifier: 388211
reversible: false
is: ENSRNOG00000004296.4
modifier: 388271
product: 388149
reactant: 388071
fast: false
reactant: 388097
modifier: 388259
reactant: 388110
product: 388136
is: http://identifiers.org/ec-code/1.1.1.105
modifier: 388186
product: 388162
modifier: 388174
modifier: 388247
reactant: 388084
is: http://identifiers.org/ec-code/3.1.3.5
modifier: 388235

388123
type: SpeciesReference
stoichiometry: 3.0
species: 326891

328279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cis-11-retinol_C20H30O

388149
type: SpeciesReference
stoichiometry: 1.0
species: 320608

388071
type: SpeciesReference
stoichiometry: 1.0
species: 320536

388097
type: SpeciesReference
stoichiometry: 1.0
species: 309455

328217
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cis-11-retinal_C20H28O

388110
type: SpeciesReference
stoichiometry: 1.0
species: 313303

388136
type: SpeciesReference
stoichiometry: 1.0
species: 308561

388162
type: SpeciesReference
stoichiometry: 1.0
species: 313449

388084
type: SpeciesReference
stoichiometry: 3.0
species: 318846

308452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: O-Acetylcarnitine_C9H17NO4

970435
type: Reaction
product: 364042
reversible: false
reactant: 364006
is: http://identifiers.org/ec-code/2.1.1.8
product: 364030
is: ENSRNOG00000005223.3
reactant: 364018
notes: R_SAMHISTA subsystem: Histidine Metabolism R_SAMHISTA equation: [c] : amet + hista --> ahcys + h + mhista
fast: false
product: 364054
name: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase

364042
type: SpeciesReference
stoichiometry: 1.0
species: 324071

324071
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Methylhistamine_C6H12N3

364006
type: SpeciesReference
stoichiometry: 1.0
species: 309395

309395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: S-Adenosyl-L-methionine_C15H23N6O5S

364030
type: SpeciesReference
stoichiometry: 1.0
species: 308973

308973
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: S-Adenosyl-L-homocysteine_C14H20N6O5S

364018
type: SpeciesReference
stoichiometry: 1.0
species: 319470

364054
type: SpeciesReference
stoichiometry: 1.0
species: 318954

967832
type: Reaction
is: ENSRNOG00000000167.4
fast: false
notes: R_ALASm subsystem: Glycine, Serine, and Threonine Metabolism R_ALASm equation: [m] : gly + h + succoa --> 5aop + co2 + coa
product: 341356
name: _5-aminolevulinate synthase
reactant: 341320
reversible: false
reactant: 341344
reactant: 341332
product: 341368
is: http://identifiers.org/ec-code/2.3.1.37
product: 341380

341356
type: SpeciesReference
stoichiometry: 1.0
species: 306246

306246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _5-Amino-4-oxopentanoate_C5H9NO3

341320
type: SpeciesReference
stoichiometry: 1.0
species: 329378

329378
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Succinyl-CoA_C25H35N7O19P3S

341344
type: SpeciesReference
stoichiometry: 1.0
species: 319002

341332
type: SpeciesReference
stoichiometry: 1.0
species: 317907

317907
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Glycine_C2H5NO2

341368
type: SpeciesReference
stoichiometry: 1.0
species: 311797

341380
type: SpeciesReference
stoichiometry: 1.0
species: 311707

312423
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate C (GalNAc6S-GlcA), degradation product 5_C23H36O24S

317531
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: D-Glucose_C6H12O6

324144
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1,3,4-trisphosphate_C6H9O15P3

315768
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Flavin adenine dinucleotide reduced_C27H33N9O15P2

325525
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Oxaloacetate_C4H2O5

323047
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Lipoylprotein_S2X

308211
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: N-Acetyl-L-glutamate_C7H9NO5

307969
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: alpha GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO

968939
type: Reaction
reactant: 351830
notes: R_ST6GALNAC31 subsystem: Sphingolipid Metabolism R_ST6GALNAC31 equation: [g] : cmpacna + gm1b_hs --> cmp + gd1alpha_hs + h
is: ENSRNOG00000028683.2
product: 351854
reversible: false
product: 351866
fast: false
name: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
product: 351878
reactant: 351842

351830
type: SpeciesReference
stoichiometry: 1.0
species: 311630

351854
type: SpeciesReference
stoichiometry: 1.0
species: 318978

351866
type: SpeciesReference
stoichiometry: 1.0
species: 317252

317252
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GD1a (homo sapiens)_C66H111N4O38FULLRCO

351878
type: SpeciesReference
stoichiometry: 1.0
species: 311582

351842
type: SpeciesReference
stoichiometry: 1.0
species: 318185

318185
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GM1b (homo sapiens)_C55H95N3O30FULLRCO

967892
type: Reaction
reactant: 341763
fast: false
product: 341787
reversible: false
product: 341775
reactant: 341751
is: http://identifiers.org/ec-code/3.2.1.96
product: 341799
reactant: 341739
notes: R_ENGASE2 subsystem: N-Glycan Degradation R_ENGASE2 equation: [c] : h2o + n2m2nm --> acgam + n2m2nmn R_ENGASE subsystem: N-Glycan Degradation R_ENGASE equation: [c] : h2o + s2l2n2m2m --> acgam + s2l2n2m2mn
is: ENSRNOG00000027498.3

341763
type: SpeciesReference
stoichiometry: 2.0
species: 318846

341787
type: SpeciesReference
stoichiometry: 1.0
species: 324544

324544
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: reducing GlcNAc removed form of n2m2nmasn (w/o peptide)_C50H84N4O36

341775
type: SpeciesReference
stoichiometry: 2.0
species: 308103

308103
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetyl-D-glucosamine_C8H15NO6

341751
type: SpeciesReference
stoichiometry: 1.0
species: 324495

324495
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: n2m2nmasn (w/o peptide linkage)_C58H97N5O41

341799
type: SpeciesReference
stoichiometry: 1.0
species: 328484

328484
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: de-Fuc, reducing GlcNAc removed form of PA6 (w/o peptide linkage)_C76H123N5O57

341739
type: SpeciesReference
stoichiometry: 1.0
species: 328436

328436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: de-Fuc form of PA6 (w/o peptide linkage)_C84H136N6O62

971012
type: Reaction
reactant: 370050
reactant: 370110
product: 370146
reactant: 370098
reactant: 370086
is: ENSRNOG00000014984.3
fast: false
product: 370134
product: 370122
product: 370159
is: http://identifiers.org/ec-code/1.8.1.7
notes: R_GTHO subsystem: Glutamate metabolism R_GTHO equation: [c] : gthox + h + nadph --> (2) gthrd + nadp R_GTHOm subsystem: Glutamate metabolism R_GTHOm equation: [m] : gthox + h + nadph --> (2) gthrd + nadp
reactant: 370074
reactant: 370062
reversible: false

370050
type: SpeciesReference
stoichiometry: 1.0
species: 318582

318582
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Oxidized glutathione_C20H30N6O12S2

370110
type: SpeciesReference
stoichiometry: 1.0
species: 324869

370146
type: SpeciesReference
stoichiometry: 2.0
species: 318642

318642
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Reduced glutathione_C10H16N3O6S

370098
type: SpeciesReference
stoichiometry: 1.0
species: 318954

370086
type: SpeciesReference
stoichiometry: 1.0
species: 319002

370134
type: SpeciesReference
stoichiometry: 2.0
species: 318618

370122
type: SpeciesReference
stoichiometry: 1.0
species: 324797

370159
type: SpeciesReference
stoichiometry: 1.0
species: 324821

370074
type: SpeciesReference
stoichiometry: 1.0
species: 324881

370062
type: SpeciesReference
stoichiometry: 1.0
species: 318606

318606
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Oxidized glutathione_C20H30N6O12S2

326493
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Phosphocreatine_C4H9N3O5P

322251
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: de-Fuc, reducing GlcNAc removed, de-Sia form of PA6 (w/o peptide linkage)_C54H91N3O41

306258
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pentaglutamyl folate (DHF)_C39H43N11O18

971756
type: Reaction
notes: R_H2CO3Dm subsystem: Miscellaneous R_H2CO3Dm equation: [m] : co2 + h2o <==> h2co3
is: http://identifiers.org/ec-code/4.2.1.1
fast: false
name: carboxylic acid dissociation
is: ENSRNOG00000021323.2
reversible: true
product: 378331
reactant: 378307
is: ENSRNOG00000010079.3
is: ENSRNOG00000002495.4
reactant: 378319
is: ENSRNOG00000029330.2
is: ENSRNOG00000010698.3
is: ENSRNOG00000019098.3
is: ENSRNOG00000009629.4

378331
type: SpeciesReference
stoichiometry: 1.0
species: 318762

318762
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: carbonic acid_H2CO3

378307
type: SpeciesReference
stoichiometry: 1.0
species: 318894

378319
type: SpeciesReference
stoichiometry: 1.0
species: 311707

322118
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 10_C89H143N7O69S2X

320872
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 15_C160H257N11O140S8

320015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 11_C79H121N5O77S4X

973942
type: Reaction
reactant: 398900
reactant: 398912
product: 398936
is: ENSRNOG00000009360.3
product: 398960
reactant: 398876
product: 398948
reactant: 398888
product: 398924
fast: false
reversible: false
notes: R_PDXPP subsystem: Vitamin B6 Metabolism R_PDXPP equation: [c] : h2o + pdx5p --> pi + pydxn R_PYDXPP subsystem: Vitamin B6 Metabolism R_PYDXPP equation: [c] : h2o + pydx5p --> pi + pydx R_HYPOE subsystem: Vitamin B6 Metabolism R_HYPOE equation: [c] : h2o + pyam5p --> pi + pydam

398900
type: SpeciesReference
stoichiometry: 3.0
species: 318846

398912
type: SpeciesReference
stoichiometry: 1.0
species: 328001

398936
type: SpeciesReference
stoichiometry: 1.0
species: 328013

328013
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyridoxal_C8H9NO3

398960
type: SpeciesReference
stoichiometry: 1.0
species: 327989

327989
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyridoxamine_C8H13N2O2

398876
type: SpeciesReference
stoichiometry: 1.0
species: 326530

398948
type: SpeciesReference
stoichiometry: 3.0
species: 326891

398888
type: SpeciesReference
stoichiometry: 1.0
species: 327977

327977
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyridoxamine 5'-phosphate_C8H12N2O5P

398924
type: SpeciesReference
stoichiometry: 1.0
species: 328025

314693
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Dopamine_C8H12NO2

976439
type: Reaction
reactant: 421868
is: http://identifiers.org/ec-code/2.4.1.38
fast: false
product: 422192
reactant: 421988
reactant: 422024
product: 422120
product: 422180
product: 422144
product: 422289
product: 422108
is: ENSRNOG00000008283.4
reactant: 422072
product: 422301
reactant: 421892
reactant: 421952
product: 422277
reactant: 421916
product: 422265
notes: R_G14Tg subsystem: N-Glycan Biosynthesis R_G14Tg equation: [g] : fn2m2masn + (2) udpgal --> (2) h + l2fn2m2masn + (2) udp R_G14T7g subsystem: Keratan sulfate biosynthesis R_G14T7g equation: [g] : ksi_pre5 + udpgal --> h + ksi_pre6 + udp R_G14T21g subsystem: Keratan sulfate biosynthesis R_G14T21g equation: [g] : ksii_core4_pre9 + udpgal --> h + ksii_core4_pre10 + udp R_G14T13g subsystem: Keratan sulfate biosynthesis R_G14T13g equation: [g] : ksi_pre23 + udpgal --> h + ksi_pre24 + udp R_G14T17g subsystem: Keratan sulfate biosynthesis R_G14T17g equation: [g] : ksi_pre35 + udpgal --> h + ksi_pre36 + udp R_G14T20g subsystem: Keratan sulfate biosynthesis R_G14T20g equation: [g] : ksii_core4_pre6 + udpgal --> h + ksii_core4_pre7 + udp R_G14T16g subsystem: Keratan sulfate biosynthesis R_G14T16g equation: [g] : ksi_pre32 + udpgal --> h + ksi_pre33 + udp R_G14T3g subsystem: Keratan sulfate biosynthesis R_G14T3g equation: [g] : ksii_core2_pre3 + udpgal --> h + ksii_core2_pre4 + udp R_G14T10g subsystem: Keratan sulfate biosynthesis R_G14T10g equation: [g] : ksi_pre14 + udpgal --> h + ksi_pre15 + udp R_G14T12g subsystem: Keratan sulfate biosynthesis R_G14T12g equation: [g] : ksi_pre20 + udpgal --> h + ksi_pre21 + udp R_G14T15g subsystem: Keratan sulfate biosynthesis R_G14T15g equation: [g] : ksi_pre29 + udpgal --> h + ksi_pre30 + udp R_G14T9g subsystem: Keratan sulfate biosynthesis R_G14T9g equation: [g] : ksi_pre11 + udpgal --> h + ksi_pre12 + udp R_G14T2g subsystem: Keratan sulfate biosynthesis R_G14T2g equation: [g] : ksii_core2_pre1 + udpgal --> h + ksii_core2_pre2 + udp R_G14T6g subsystem: Keratan sulfate biosynthesis R_G14T6g equation: [g] : ksi_pre2 + udpgal --> h + ksi_pre3 + udp R_G14T19g subsystem: Keratan sulfate biosynthesis R_G14T19g equation: [g] : ksii_core4_pre3 + udpgal --> h + ksii_core4_pre4 + udp R_G14T4g subsystem: Keratan sulfate biosynthesis R_G14T4g equation: [g] : ksii_core2_pre6 + udpgal --> h + ksii_core2_pre7 + udp R_G14T8g subsystem: Keratan sulfate …
product: 422228
reactant: 422036
is: ENSRNOG00000003551.3
product: 422373
product: 422349
product: 422252
reactant: 422084
product: 422337
reactant: 422096
product: 422240
reversible: false
product: 422216
reactant: 421964
reactant: 421976
reactant: 422000
product: 422204
reactant: 422012
reactant: 421928
product: 422361
product: 422325
reactant: 422060
product: 422313
reactant: 421880
reactant: 422048
reactant: 421940
product: 422168
reactant: 421843
reactant: 421855
product: 422132
reactant: 421904
product: 422156

421868
type: SpeciesReference
stoichiometry: 1.0
species: 322227

322227
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 9_C83H133N7O64S2X

422192
type: SpeciesReference
stoichiometry: 1.0
species: 322131

421988
type: SpeciesReference
stoichiometry: 1.0
species: 321646

321646
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 32_C227H362N16O192S10X

422024
type: SpeciesReference
stoichiometry: 1.0
species: 321489

422120
type: SpeciesReference
stoichiometry: 1.0
species: 322118

422180
type: SpeciesReference
stoichiometry: 1.0
species: 321381

422144
type: SpeciesReference
stoichiometry: 1.0
species: 321708

422289
type: SpeciesReference
stoichiometry: 1.0
species: 321417

422108
type: SpeciesReference
stoichiometry: 1.0
species: 321622

422072
type: SpeciesReference
stoichiometry: 23.0
species: 331007

331007
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: UDPgalactose_C15H22N2O17P2

422301
type: SpeciesReference
stoichiometry: 1.0
species: 321695

321695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 36_C247H394N17O210S11X

421892
type: SpeciesReference
stoichiometry: 1.0
species: 321442

321442
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 17_C157H252N11O127S5X

421952
type: SpeciesReference
stoichiometry: 1.0
species: 321997

321997
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 6_C61H98N5O46SX

422277
type: SpeciesReference
stoichiometry: 1.0
species: 322009

421916
type: SpeciesReference
stoichiometry: 1.0
species: 321369

321369
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 11_C129H208N9O101S3X

422265
type: SpeciesReference
stoichiometry: 1.0
species: 321781

422228
type: SpeciesReference
stoichiometry: 23.0
species: 318978

422036
type: SpeciesReference
stoichiometry: 1.0
species: 321682

321682
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 35_C241H384N17O205S11X

422373
type: SpeciesReference
stoichiometry: 1.0
species: 321501

422349
type: SpeciesReference
stoichiometry: 1.0
species: 321925

321925
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 10_C81H130N6O64S2X

422252
type: SpeciesReference
stoichiometry: 1.0
species: 321453

422084
type: SpeciesReference
stoichiometry: 1.0
species: 322033

422337
type: SpeciesReference
stoichiometry: 1.0
species: 321973

422096
type: SpeciesReference
stoichiometry: 1.0
species: 322191

322191
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II biosynthesis, precursor 6_C69H111N6O51SX

422240
type: SpeciesReference
stoichiometry: 1.0
species: 321658

422216
type: SpeciesReference
stoichiometry: 1.0
species: 322239

322239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799

421964
type: SpeciesReference
stoichiometry: 1.0
species: 321562

321562
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 26_C199H318N14O166S8X

421976
type: SpeciesReference
stoichiometry: 1.0
species: 321610

422000
type: SpeciesReference
stoichiometry: 1.0
species: 321961

422204
type: SpeciesReference
stoichiometry: 23.0
species: 330850

422012
type: SpeciesReference
stoichiometry: 1.0
species: 321937

421928
type: SpeciesReference
stoichiometry: 1.0
species: 315961

315961
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: N4-{N-Acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine_C56H93N4O39X

422361
type: SpeciesReference
stoichiometry: 1.0
species: 321745

422325
type: SpeciesReference
stoichiometry: 1.0
species: 322167

422060
type: SpeciesReference
stoichiometry: 1.0
species: 321769

321769
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 8_C115H186N8O88S2X

422313
type: SpeciesReference
stoichiometry: 1.0
species: 321949

421880
type: SpeciesReference
stoichiometry: 1.0
species: 321733

321733
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 5_C101H164N7O75SX

422048
type: SpeciesReference
stoichiometry: 1.0
species: 321526

321526
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 23_C185H296N13O153S7X

421940
type: SpeciesReference
stoichiometry: 1.0
species: 321598

321598
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate I biosynthesis, precursor 29_C213H340N15O179S9X

422168
type: SpeciesReference
stoichiometry: 1.0
species: 321537

421843
type: SpeciesReference
stoichiometry: 1.0
species: 322155

421855
type: SpeciesReference
stoichiometry: 1.0
species: 311881

311881
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Core 4_C24H40N3O15X

422132
type: SpeciesReference
stoichiometry: 1.0
species: 321574

421904
type: SpeciesReference
stoichiometry: 1.0
species: 321405

422156
type: SpeciesReference
stoichiometry: 1.0
species: 322203

967266
type: Reaction
name: threonine synthase
product: 336304
reactant: 336268
is: http://identifiers.org/ec-code/4.2.3.1
notes: R_THRS subsystem: Glycine, Serine, and Threonine Metabolism R_THRS equation: [c] : h2o + phom --> pi + thr-L
reactant: 336280
fast: false
is: ENSRNOG00000033076.2
reversible: false
product: 336292

336304
type: SpeciesReference
stoichiometry: 1.0
species: 326891

336268
type: SpeciesReference
stoichiometry: 1.0
species: 318846

336280
type: SpeciesReference
stoichiometry: 1.0
species: 326795

326795
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: O-Phospho-L-homoserine_C4H8NO6P

336292
type: SpeciesReference
stoichiometry: 1.0
species: 330186

324459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Myristoyl-ACP (n-C14:0ACP)_C25H47N2O8PRS

330369
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: timnodonyl coenzyme A_C41H60N7O17P3S

974434
type: Reaction
fast: false
product: 405502
reactant: 405454
reactant: 405466
product: 405478
reversible: false
product: 405490
notes: R_3SALACBOXL subsystem: Taurine and hypotaurine metabolism R_3SALACBOXL equation: [c] : 3sala + h --> co2 + hyptaur R_LCYSTCBOXL subsystem: Taurine and hypotaurine metabolism R_LCYSTCBOXL equation: [c] : Lcyst + h --> co2 + taur
is: http://identifiers.org/ec-code/4.1.1.15
is: ENSRNOG00000011573.3
reactant: 405442

405502
type: SpeciesReference
stoichiometry: 2.0
species: 311681

405454
type: SpeciesReference
stoichiometry: 1.0
species: 305496

405466
type: SpeciesReference
stoichiometry: 2.0
species: 318954

405478
type: SpeciesReference
stoichiometry: 1.0
species: 329486

405490
type: SpeciesReference
stoichiometry: 1.0
species: 320271

405442
type: SpeciesReference
stoichiometry: 1.0
species: 307016

327230
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _5-Diphosphoinositol pentakisphosphate_C6H6O27P7

318294
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GlcNAc-alpha-1,4-Core 1_C22H37N2O15X

317604
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: D-Glucuronate_C6H9O7

331344
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: UTP_C9H11N2O15P3

970668
type: Reaction
modifier: 366598
is: ENSRNOG00000021323.2
product: 366574
reactant: 366526
modifier: 366586
is: http://identifiers.org/ec-code/4.2.1.1
product: 366538
product: 366562
fast: false
product: 366550
modifier: 366610
is: ENSRNOG00000010079.3
is: ENSRNOG00000009629.4
reactant: 366514
reactant: 366502
is: ENSRNOG00000002495.4
reversible: false
notes: R_CBPSam subsystem: Glutamate metabolism R_CBPSam equation: [m] : (2) atp + hco3 + nh4 --> (2) adp + cbp + (2) h + pi R_H2CO3D subsystem: Miscellaneous R_H2CO3D equation: [c] : co2 + h2o <==> h2co3
is: http://identifiers.org/ec-code/6.3.4.16
is: ENSRNOG00000010698.3

366574
type: SpeciesReference
stoichiometry: 2.0
species: 319002

366526
type: SpeciesReference
stoichiometry: 2.0
species: 310166

366538
type: SpeciesReference
stoichiometry: 1.0
species: 326939

326939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Phosphate_HO4P

366562
type: SpeciesReference
stoichiometry: 1.0
species: 310866

310866
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Carbamoyl phosphate_CH2NO5P

366550
type: SpeciesReference
stoichiometry: 2.0
species: 308645

366514
type: SpeciesReference
stoichiometry: 1.0
species: 325016

325016
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Ammonium_H4N

366502
type: SpeciesReference
stoichiometry: 1.0
species: 319134

319134
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Bicarbonate_CHO3

332010
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Xylulose_C5H10O5

968433
type: Reaction
reactant: 347076
product: 347124
reversible: true
is: ENSRNOG00000006729.4
product: 347136
is: ENSRNOG00000009480.3
notes: R_NCKt subsystem: Transport, Extracellular R_NCKt equation: ca2[e] + k[e] + (4) na1[c] <==> ca2[c] + k[c] + (4) na1[e]
name: Na+/Ca2+-K+ exchange
reactant: 347100
product: 347112
reactant: 347088
fast: false

347076
type: SpeciesReference
stoichiometry: 1.0
species: 310709

347124
type: SpeciesReference
stoichiometry: 1.0
species: 320764

347136
type: SpeciesReference
stoichiometry: 4.0
species: 324628

347100
type: SpeciesReference
stoichiometry: 4.0
species: 324616

347112
type: SpeciesReference
stoichiometry: 1.0
species: 310697

347088
type: SpeciesReference
stoichiometry: 1.0
species: 320776

304749
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glycerate 2-phosphate_C3H4O7P

976499
type: Reaction
product: 423243
reactant: 423207
is: http://identifiers.org/ec-code/3.1.3.18
name: Phosphoglycolate phosphatase
notes: R_PGLYCP subsystem: Glyoxylate and Dicarboxylate Metabolism R_PGLYCP equation: [c] : 2pglyc + h2o --> glyclt + pi
is: ENSRNOG00000009570.3
reactant: 423219
fast: false
reversible: false
is: ENSRNOG00000009536.4
product: 423231

423243
type: SpeciesReference
stoichiometry: 1.0
species: 326891

423207
type: SpeciesReference
stoichiometry: 1.0
species: 318846

423219
type: SpeciesReference
stoichiometry: 1.0
species: 304761

304761
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Phosphoglycolate_C2H2O6P

423231
type: SpeciesReference
stoichiometry: 1.0
species: 318052

305876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Imidazolone-5-propanoate_C6H7N2O3

314452
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: DNA 5-methylcytosine_C11H19O8PR2

312014
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: ceramide (homo sapiens)_C18H36NO2FULLRCO

969359
type: Reaction
is: ENSRNOG00000014783.4
fast: false
name: alpha,alpha-trehalase
notes: R_TREH subsystem: Starch and Sucrose Metabolism R_TREH equation: [c] : h2o + tre --> (2) glc-D
is: http://identifiers.org/ec-code/3.2.1.28
reversible: false
product: 355381
reactant: 355369
reactant: 355357

355381
type: SpeciesReference
stoichiometry: 2.0
species: 317507

355369
type: SpeciesReference
stoichiometry: 1.0
species: 318846

355357
type: SpeciesReference
stoichiometry: 1.0
species: 330465

330465
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Trehalose_C12H22O11

314319
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dihomo-gamma-linolenyl carnitine_C27H47NO4

325101
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Nicotinate D-ribonucleotide_C11H12NO9P

976151
type: Reaction
product: 419969
reactant: 419921
reversible: false
reactant: 419909
product: 419957
reactant: 419897
product: 419945
reactant: 419933
notes: R_CBR2 subsystem: Eicosanoid Metabolism R_CBR2 equation: [c] : h + nadph + prostge2 --> nadp + prostgf2 R_CBR1 subsystem: Eicosanoid Metabolism R_CBR1 equation: [c] : h + nadph + prostg1 --> nadp + prostge1
fast: false
is: ENSRNOG00000001702.4
is: ENSRNOG00000032165.2
is: ENSRNOG00000032830.2

419969
type: SpeciesReference
stoichiometry: 2.0
species: 324797

419921
type: SpeciesReference
stoichiometry: 2.0
species: 318954

419909
type: SpeciesReference
stoichiometry: 1.0
species: 327627

327627
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: (13E)-11alpha-Hydroxy-9,15-dioxoprost-13-enoate_C20H31O5

419957
type: SpeciesReference
stoichiometry: 1.0
species: 327736

327736
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Prostaglandin F2alpha_C20H33O5

419897
type: SpeciesReference
stoichiometry: 1.0
species: 327700

419945
type: SpeciesReference
stoichiometry: 1.0
species: 327675

327675
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Prostaglandin E1_C20H33O5

419933
type: SpeciesReference
stoichiometry: 2.0
species: 324869

970473
type: Reaction
product: 364441
reactant: 364284
reactant: 364260
reversible: false
product: 364357
reactant: 364296
reactant: 364308
product: 364477
product: 364465
product: 364393
notes: R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_PROt4 subsystem: Transport, Extracellular R_PROt4 equation: na1[e] + pro-L[e] --> na1[c] + pro-L[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_ARGtiDF subsystem: Transport, Extracellular R_ARGtiDF equation: arg-L[e] --> arg-L[c] R_LYStiDF subsystem: Transport, Extracellular R_LYStiDF equation: lys-L[e] --> lys-L[c] R_HIStiDF subsystem: Transport, Extracellular R_HIStiDF equation: his-L[e] --> his-L[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c]
product: 364417
reactant: 364198
reactant: 364223
reactant: 364272
product: 364405
reactant: 364236
product: 364381
reactant: 364332
fast: false
reactant: 364210
product: 364429
product: 364345
is: ENSRNOG00000006653.2
product: 364453
reactant: 364320
reactant: 364248
product: 364369

364441
type: SpeciesReference
stoichiometry: 1.0
species: 322471

364284
type: SpeciesReference
stoichiometry: 1.0
species: 317883

364260
type: SpeciesReference
stoichiometry: 1.0
species: 327579

327579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Proline_C5H9NO2

364357
type: SpeciesReference
stoichiometry: 1.0
species: 317871

364296
type: SpeciesReference
stoichiometry: 1.0
species: 323095

323095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Lysine_C6H15N2O2

364308
type: SpeciesReference
stoichiometry: 1.0
species: 317630

364477
type: SpeciesReference
stoichiometry: 1.0
species: 327567

327567
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Proline_C5H9NO2

364465
type: SpeciesReference
stoichiometry: 1.0
species: 326723

326723
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Phenylalanine_C9H11NO2

364393
type: SpeciesReference
stoichiometry: 1.0
species: 319446

364417
type: SpeciesReference
stoichiometry: 1.0
species: 309961

364198
type: SpeciesReference
stoichiometry: 1.0
species: 319458

319458
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Histidine_C6H9N3O2

364223
type: SpeciesReference
stoichiometry: 1.0
species: 309263

364272
type: SpeciesReference
stoichiometry: 1.0
species: 309973

309973
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Arginine_C6H15N4O2

364405
type: SpeciesReference
stoichiometry: 8.0
species: 324616

364236
type: SpeciesReference
stoichiometry: 1.0
species: 310046

364381
type: SpeciesReference
stoichiometry: 1.0
species: 317617

364332
type: SpeciesReference
stoichiometry: 1.0
species: 326735

326735
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Phenylalanine_C9H11NO2

364210
type: SpeciesReference
stoichiometry: 1.0
species: 322483

322483
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Leucine_C6H13NO2

364429
type: SpeciesReference
stoichiometry: 1.0
species: 310033

364345
type: SpeciesReference
stoichiometry: 1.0
species: 323083

364453
type: SpeciesReference
stoichiometry: 1.0
species: 309251

364320
type: SpeciesReference
stoichiometry: 1.0
species: 328785

364248
type: SpeciesReference
stoichiometry: 8.0
species: 324628

364369
type: SpeciesReference
stoichiometry: 1.0
species: 328773

331103
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: UMP_C9H11N2O9P

326457
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Procollagen 5-hydroxy-L-lysine_C6H14N2O3

318330
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GP1c alpha (homo sapiens)_C99H159N7O62FULLRCO

973185
type: Reaction
reactant: 390542
fast: false
reactant: 390554
product: 390603
reversible: true
is: ENSRNOG00000015686.4
notes: R_CERT2rt subsystem: Transport, Endoplasmic Reticular R_CERT2rt equation: gluside_hs[c] <==> gluside_hs[r] R_CERT1gt subsystem: Transport, Golgi Apparatus R_CERT1gt equation: crm_hs[c] <==> crm_hs[g] R_CERT2gt subsystem: Transport, Golgi Apparatus R_CERT2gt equation: gluside_hs[c] <==> gluside_hs[g] R_CERT1rt subsystem: Transport, Endoplasmic Reticular R_CERT1rt equation: crm_hs[c] <==> crm_hs[r]
product: 390566
product: 390591
product: 390579

390542
type: SpeciesReference
stoichiometry: 2.0
species: 317774

317774
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: glucocerebroside (homo sapiens)_C24H46NO7FULLRCO

390554
type: SpeciesReference
stoichiometry: 2.0
species: 311990

311990
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: ceramide (homo sapiens)_C18H36NO2FULLRCO

390603
type: SpeciesReference
stoichiometry: 1.0
species: 317811

317811
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glucocerebroside (homo sapiens)_C24H46NO7FULLRCO

390566
type: SpeciesReference
stoichiometry: 1.0
species: 312026

312026
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ceramide (homo sapiens)_C18H36NO2FULLRCO

390591
type: SpeciesReference
stoichiometry: 1.0
species: 312002

312002
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: ceramide (homo sapiens)_C18H36NO2FULLRCO

390579
type: SpeciesReference
stoichiometry: 1.0
species: 317787

317787
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: glucocerebroside (homo sapiens)_C24H46NO7FULLRCO

315082
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dUTP_C9H11N2O14P3

326010
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: phosphatidic acid (homo sapiens)_C3H5O4PFULLRCO2FULLR2CO2

327314
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Inorganic triphosphate_HO10P3

326963
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Phosphate_HO4P

311000
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N,N'-Diacetylchitobiosyldiphosphodolichol, human liver homolog_C1240H2028N20O170P20

325683
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: octadecenoate (n-C18:1)_C18H33O2

307283
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: R total 2 carnitine_CO2FULLR2C7H14NO2

966942
type: Reaction
reactant: 333381
is: http://identifiers.org/ec-code/2.1.2.3
reactant: 333357
reactant: 333369
is: ENSRNOG00000015511.3
is: http://identifiers.org/ec-code/3.5.4.10
notes: R_IMPC subsystem: IMP Biosynthesis R_IMPC equation: [c] : h2o + imp <==> fprica R_AICART subsystem: IMP Biosynthesis R_AICART equation: [c] : 10fthf + aicar <==> fprica + thf
product: 333417
fast: false
reactant: 333393
product: 333405
reversible: true

333381
type: SpeciesReference
stoichiometry: 1.0
species: 304004

304004
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _10-Formyltetrahydrofolate_C20H21N7O7

333357
type: SpeciesReference
stoichiometry: 1.0
species: 309046

309046
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Amino-1-(5-Phospho-D-ribosyl)imidazole-4-carboxamide_C9H13N4O8P

333369
type: SpeciesReference
stoichiometry: 1.0
species: 318846

333417
type: SpeciesReference
stoichiometry: 2.0
species: 316117

316117
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide_C10H13N4O9P

333393
type: SpeciesReference
stoichiometry: 1.0
species: 320536

333405
type: SpeciesReference
stoichiometry: 1.0
species: 330040

330040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5,6,7,8-Tetrahydrofolate_C19H21N7O6

977399
type: Reaction
reactant: 432999
product: 433109
reactant: 433047
product: 433120
reactant: 433023
reactant: 433011
product: 433206
product: 433158
notes: R_ST6GALNAC26 subsystem: Sphingolipid Metabolism R_ST6GALNAC26 equation: [g] : cmpacna + gt1alpha_hs --> cmp + gq1balpha_hs + h R_ST6GALNAC25 subsystem: Sphingolipid Metabolism R_ST6GALNAC25 equation: [g] : cmpacna + gd1alpha_hs --> cmp + gt1alpha_hs + h R_ST6GALNAC24 subsystem: Sphingolipid Metabolism R_ST6GALNAC24 equation: [g] : cmpacna + gm1a_hs --> cmp + gd1b2_hs + h R_ST6GALNAC22 subsystem: Sphingolipid Metabolism R_ST6GALNAC22 equation: [g] : acngalgbside_hs + cmpacna --> acn23acngalgbside_hs + cmp + h R_ST6GALNAC21 subsystem: Sphingolipid Metabolism R_ST6GALNAC21 equation: [g] : acngalgbside_hs + cmpacna --> acn13acngalgbside_hs + cmp + h R_ST6GALNAC27 subsystem: Sphingolipid Metabolism R_ST6GALNAC27 equation: [g] : cmpacna + gt1c_hs --> cmp + gq1c_hs + h R_ST6GALNAC23 subsystem: Sphingolipid Metabolism R_ST6GALNAC23 equation: [g] : cmpacna + ga2_hs --> cmp + gm2a_hs + h R_ST6GALNAC28 subsystem: Sphingolipid Metabolism R_ST6GALNAC28 equation: [g] : cmpacna + gq1c_hs --> cmp + gp1c_hs + h
product: 433194
reactant: 433059
product: 433133
product: 433096
reactant: 433035
product: 433145
reversible: false
product: 433182
is: ENSRNOG00000012083.4
product: 433170
reactant: 433084
reactant: 433071
fast: false

432999
type: SpeciesReference
stoichiometry: 8.0
species: 311630

433109
type: SpeciesReference
stoichiometry: 8.0
species: 318978

433047
type: SpeciesReference
stoichiometry: 2.0
species: 308428

308428
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: sialyl galactosylgloboside (homo sapiens)_C61H105N3O35FULLRCO

433120
type: SpeciesReference
stoichiometry: 1.0
species: 318402

318402
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GQ1balpha (homo sapiens)_C88H143N6O54FULLRCO

433023
type: SpeciesReference
stoichiometry: 1.0
species: 318510

318510
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GT1aalpha (homo sapiens)_C77H127N5O46FULLRCO

433011
type: SpeciesReference
stoichiometry: 1.0
species: 317252

433206
type: SpeciesReference
stoichiometry: 1.0
species: 317264

317264
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GD1beta (homo sapiens)_C66H111N4O38FULLRCO

433158
type: SpeciesReference
stoichiometry: 1.0
species: 308296

308296
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: sialyl (1,3) sialyl (2,6) galactosylgloboside (homo sapiens)_C72H121N4O43FULLRCO

433194
type: SpeciesReference
stoichiometry: 1.0
species: 318210

318210
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GM2alpha (homo sapiens)_C49H85N3O25FULLRCO

433059
type: SpeciesReference
stoichiometry: 1.0
species: 318173

318173
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GM1alpha (homo sapiens)_C55H95N3O30FULLRCO

433133
type: SpeciesReference
stoichiometry: 1.0
species: 308308

308308
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: sialyl (2,3) sialyl (2,6) galactosylgloboside (homo sapiens)_C72H121N4O43FULLRCO

433096
type: SpeciesReference
stoichiometry: 1.0
species: 318318

318318
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GP1c (homo sapiens)_C99H159N7O62FULLRCO

433035
type: SpeciesReference
stoichiometry: 1.0
species: 316756

316756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GA2 (homo sapiens)_C38H69N2O17FULLRCO

433145
type: SpeciesReference
stoichiometry: 1.0
species: 318510

433182
type: SpeciesReference
stoichiometry: 8.0
species: 311582

433170
type: SpeciesReference
stoichiometry: 1.0
species: 318414

318414
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GQ1c (homo sapiens)_C88H143N6O54FULLRCO

433084
type: SpeciesReference
stoichiometry: 1.0
species: 318414

433071
type: SpeciesReference
stoichiometry: 1.0
species: 318534

318534
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GT1c (homo sapiens)_C77H127N5O46FULLRCO

973714
type: Reaction
name: adenosine kinase
notes: R_ADNK1 subsystem: Nucleotides R_ADNK1 equation: [c] : adn + atp --> adp + amp + h
is: ENSRNOG00000012325.3
fast: false
product: 395963
reversible: false
reactant: 395951
product: 395987
product: 395975
reactant: 395939
is: http://identifiers.org/ec-code/2.7.1.20

395963
type: SpeciesReference
stoichiometry: 1.0
species: 308621

395951
type: SpeciesReference
stoichiometry: 1.0
species: 308561

395987
type: SpeciesReference
stoichiometry: 1.0
species: 318954

395975
type: SpeciesReference
stoichiometry: 1.0
species: 309455

395939
type: SpeciesReference
stoichiometry: 1.0
species: 310142

330441
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Reduced thioredoxin_XH2

305800
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4 hydroxy debrisoquine_C10H14N3O

972321
type: Reaction
product: 382490
product: 382478
reactant: 382442
fast: false
reversible: false
product: 382466
is: ENSRNOG00000031279.1
reactant: 382406
product: 382454
product: 382514
product: 382502
is: http://identifiers.org/ec-code/2.8.2.2
reactant: 382394
reactant: 382418
notes: R_PRGNLONESULT subsystem: Steroid Metabolism R_PRGNLONESULT equation: [c] : paps + prgnlone --> h + pap + prgnlones R_TSTSTERONESULT subsystem: Steroid Metabolism R_TSTSTERONESULT equation: [c] : paps + tststerone --> h + pap + tststerones R_DHEASULT subsystem: Steroid Metabolism R_DHEASULT equation: [c] : dhea + paps --> dheas + h + pap R_5ADTSTSTERONESULT subsystem: Steroid Metabolism R_5ADTSTSTERONESULT equation: [c] : 5adtststerone + paps --> 5adtststerones + h + pap
is: ENSRNOG00000030636.2
reactant: 382430

382490
type: SpeciesReference
stoichiometry: 1.0
species: 327398

327398
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: pregnenolone sulfate_C21H31O5S

382478
type: SpeciesReference
stoichiometry: 1.0
species: 313994

382442
type: SpeciesReference
stoichiometry: 4.0
species: 326373

326373
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3'-Phosphoadenylyl sulfate_C10H11N5O13P2S

382466
type: SpeciesReference
stoichiometry: 1.0
species: 306209

306209
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5alpha-Dihydrotestosterone sulfate_C19H29O5S

382406
type: SpeciesReference
stoichiometry: 1.0
species: 330562

330562
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Testosterone_C19H28O2

382454
type: SpeciesReference
stoichiometry: 4.0
species: 326349

326349
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adenosine 3',5'-bisphosphate_C10H11N5O10P2

382514
type: SpeciesReference
stoichiometry: 4.0
species: 318954

382502
type: SpeciesReference
stoichiometry: 1.0
species: 330622

330622
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: testosterone sulfate_C19H27O5S

382394
type: SpeciesReference
stoichiometry: 1.0
species: 313970

313970
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dehydroepiandrosterone_C19H28O2

382418
type: SpeciesReference
stoichiometry: 1.0
species: 306149

306149
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5alpha-Dihydrotestosterone_C19H30O2

382430
type: SpeciesReference
stoichiometry: 1.0
species: 327362

321346
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I_C247H393N17O213S12X

325064
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Nicotinate D-ribonucleoside_C11H13NO6

328953
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sphinganine 1-phosphate_C18H39NO5P

327869
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: O-Phospho-L-serine_C3H6NO6P

971240
type: Reaction
modifier: 371794
reactant: 371721
is: ENSRNOG00000017777.2
notes: R_AHC subsystem: Methionine Metabolism R_AHC equation: [c] : ahcys + h2o <==> adn + hcys-L R_SEAHCYSHYD subsystem: Selenoamino acid metabolism R_SEAHCYSHYD equation: [c] : h2o + seahcys --> adn + selhcys
fast: false
product: 371758
is: ENSRNOG00000025827.2
reactant: 371733
modifier: 371806
is: ENSRNOG00000013516.4
is: ENSRNOG00000013206.3
is: http://identifiers.org/ec-code/3.3.1.1
product: 371746
modifier: 371770
modifier: 371782
reversible: false

371721
type: SpeciesReference
stoichiometry: 1.0
species: 328604

328604
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se

371758
type: SpeciesReference
stoichiometry: 1.0
species: 308561

371733
type: SpeciesReference
stoichiometry: 1.0
species: 318846

371746
type: SpeciesReference
stoichiometry: 1.0
species: 328701

328701
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Selenohomocysteine_C4H9NO2Se

321065
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 29_C96H157N6O80S3

315444
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _16-Glucuronide-estriol_C24H32O9

310576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Butyrate (n-C4:0)_C4H7O2

972381
type: Reaction
reactant: 383322
product: 383623
product: 383635
product: 383792
reactant: 383041
reactant: 383176
reactant: 383139
reactant: 383262
product: 383539
reactant: 383152
fast: false
product: 383780
reactant: 383346
reactant: 383102
product: 383719
product: 383731
product: 383647
reactant: 383382
product: 383743
product: 383659
product: 383671
reactant: 383065
reactant: 383237
product: 383575
reactant: 383286
product: 383587
reversible: false
reactant: 383212
reactant: 383126
notes: R_RTOTALCRNt subsystem: Carnitine shuttle R_RTOTALCRNt equation: Rtotalcrn[c] --> Rtotalcrn[m] R_LNLNCGCRNt subsystem: Carnitine shuttle R_LNLNCGCRNt equation: lnlncgcrn[c] --> lnlncgcrn[m] R_ACRNtm subsystem: Transport, Mitochondrial R_ACRNtm equation: acrn[c] --> acrn[m] R_LNLNCACRNt subsystem: Carnitine shuttle R_LNLNCACRNt equation: lnlncacrn[c] --> lnlncacrn[m] R_DLNLCGCRNt subsystem: Carnitine shuttle R_DLNLCGCRNt equation: dlnlcgcrn[c] --> dlnlcgcrn[m] R_STRDNCCRNt subsystem: Carnitine shuttle R_STRDNCCRNt equation: strdnccrn[c] --> strdnccrn[m] R_CRNtim subsystem: Transport, Mitochondrial R_CRNtim equation: crn[m] --> crn[c] R_TETTET6CRNt subsystem: Carnitine shuttle R_TETTET6CRNt equation: tettet6crn[c] --> tettet6crn[m] R_RTOTAL2CRNt subsystem: Carnitine shuttle R_RTOTAL2CRNt equation: Rtotal2crn[c] --> Rtotal2crn[m] R_DCSPTN1CRNt subsystem: Carnitine shuttle R_DCSPTN1CRNt equation: dcsptn1crn[c] --> dcsptn1crn[m] R_C161CRN2t subsystem: Carnitine shuttle R_C161CRN2t equation: hdd2crn[c] --> hdd2crn[m] R_C181CRNt subsystem: Carnitine shuttle R_C181CRNt equation: odecrn[c] --> odecrn[m] R_EICOSTETCRNt subsystem: Carnitine shuttle R_EICOSTETCRNt equation: eicostetcrn[c] --> eicostetcrn[m] R_TTDCRNt subsystem: Carnitine shuttle R_TTDCRNt equation: ttdcrn[c] --> ttdcrn[m] R_TMNDNCCRNt subsystem: Carnitine shuttle R_TMNDNCCRNt equation: tmndnccrn[c] --> tmndnccrn[m] R_CLPNDCRNt subsystem: Carnitine shuttle R_CLPNDCRNt equation: clpndcrn[c] --> clpndcrn[m] R_LGNCCRNt subsystem: Carnitine shuttle R_LGNCCRNt equation: lgnccrn[c] --> lgnccrn[m] R_VACCCRNt subsystem: Carnitine shuttle R_VACCCRNt equation: vacccrn[c] --> vacccrn[m] R_ADRNCRNt subsystem: Carnitine shuttle R_ADRNCRNt equation: adrncrn[c] --> adrncrn[m] R_NRVNCCRNt subsystem: Carnitine shuttle R_NRVNCCRNt equation: nrvnccrn[c] --> nrvnccrn[m] R_TETPENT6CRNt subsystem: Carnitine shuttle R_TETPENT6CRNt equation: tetpent6crn[c] --> tetpent6crn[m] R_LNELDCCRNt subsystem: Carnitine shuttle R_LNELDCCRNt equati…
product: 383804
is: ENSRNOG00000020288.3
reactant: 383029
product: 383683
reactant: 383406
product: 383551
product: 383695
product: 383599
reactant: 383358
product: 383454
product: 383563
product: 383467
reactant: 383334
product: 383755
product: 383503
reactant: 383394
product: 383479
product: 383767
product: 383816
reactant: 383310
reactant: 383370
product: 383491
reactant: 383200
product: 383442
reactant: 383053
reactant: 383188
product: 383611
reactant: 383274
reactant: 383164
product: 383430
reactant: 383250
reactant: 383224
product: 383707
product: 383515
reactant: 383114
product: 383527
reactant: 383418
reactant: 383090
reactant: 383077
reactant: 383298

383322
type: SpeciesReference
stoichiometry: 1.0
species: 307343

383623
type: SpeciesReference
stoichiometry: 1.0
species: 327036

327036
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Palmitoylcarnitine_C23H45NO4

383635
type: SpeciesReference
stoichiometry: 1.0
species: 308464

308464
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: O-Acetylcarnitine_C9H17NO4

383792
type: SpeciesReference
stoichiometry: 1.0
species: 322867

322867
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Linoleyl carnitine_C25H45NO4

383041
type: SpeciesReference
stoichiometry: 1.0
species: 322675

383176
type: SpeciesReference
stoichiometry: 1.0
species: 330381

383139
type: SpeciesReference
stoichiometry: 1.0
species: 307451

383262
type: SpeciesReference
stoichiometry: 1.0
species: 311521

383539
type: SpeciesReference
stoichiometry: 1.0
species: 319650

319650
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: heptadecanoyl carnitine_C24H47NO4

383152
type: SpeciesReference
stoichiometry: 1.0
species: 322915

383780
type: SpeciesReference
stoichiometry: 1.0
species: 314319

383346
type: SpeciesReference
stoichiometry: 1.0
species: 331417

383102
type: SpeciesReference
stoichiometry: 1.0
species: 319314

383719
type: SpeciesReference
stoichiometry: 1.0
species: 313401

383731
type: SpeciesReference
stoichiometry: 1.0
species: 322927

322927
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: alpha-linolenyl carnitine_C25H43NO4

383647
type: SpeciesReference
stoichiometry: 1.0
species: 329764

329764
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: tetracosapentaenoyl carnitine_C31H51NO4

383382
type: SpeciesReference
stoichiometry: 1.0
species: 319410

383743
type: SpeciesReference
stoichiometry: 1.0
species: 329836

329836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: tetracosapentaenoyl carnitine_C31H51NO4

383659
type: SpeciesReference
stoichiometry: 1.0
species: 329305

329305
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: stearidonyl carnitine_C25H41NO4

383671
type: SpeciesReference
stoichiometry: 1.0
species: 322687

322687
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: lignoceryl carnitine_C31H61NO4

383065
type: SpeciesReference
stoichiometry: 1.0
species: 314307

383237
type: SpeciesReference
stoichiometry: 1.0
species: 329196

383575
type: SpeciesReference
stoichiometry: 1.0
species: 325356

325356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nervonyl carnitine_C31H59NO4

383286
type: SpeciesReference
stoichiometry: 1.0
species: 312074

312074
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
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383587
type: SpeciesReference
stoichiometry: 1.0
species: 308850

308850
type: Species
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boundary condition: false
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initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Adrenyl carnitine_C29H49NO4

383212
type: SpeciesReference
stoichiometry: 1.0
species: 308452

383126
type: SpeciesReference
stoichiometry: 1.0
species: 327023

383804
type: SpeciesReference
stoichiometry: 1.0
species: 331429

331429
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Vaccenyl carnitine_C25H47NO4

383029
type: SpeciesReference
stoichiometry: 1.0
species: 322987

383683
type: SpeciesReference
stoichiometry: 1.0
species: 327929

327929
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: pendtadenoyl carnitine_C22H43NO4

383406
type: SpeciesReference
stoichiometry: 1.0
species: 329896

383551
type: SpeciesReference
stoichiometry: 1.0
species: 319422

319422
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: hexacosanoyl carnitine_C33H65NO4

383695
type: SpeciesReference
stoichiometry: 1.0
species: 330718

383599
type: SpeciesReference
stoichiometry: 1.0
species: 315263

315263
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Eicosatetranoyl carnitine_C27H45NO4

383358
type: SpeciesReference
stoichiometry: 1.0
species: 322795

383454
type: SpeciesReference
stoichiometry: 1.0
species: 322807

322807
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Linoelaidyl carnitine_C25H45NO4

383563
type: SpeciesReference
stoichiometry: 1.0
species: 311533

383467
type: SpeciesReference
stoichiometry: 1.0
species: 330393

330393
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Timnodonyl carnitine_C27H43NO4

383334
type: SpeciesReference
stoichiometry: 1.0
species: 325344

383755
type: SpeciesReference
stoichiometry: 1.0
species: 325829

325829
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: octadecenoyl carnitine_C25H47NO4

383503
type: SpeciesReference
stoichiometry: 1.0
species: 315299

315299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Elaidic carnitine_C25H47NO4

383394
type: SpeciesReference
stoichiometry: 1.0
species: 322855

383479
type: SpeciesReference
stoichiometry: 1.0
species: 322999

322999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: gamma-linolenyl carnitine_C25H43NO4

383767
type: SpeciesReference
stoichiometry: 1.0
species: 329908

329908
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Tetracosatetraenoyl carnitine_C31H53NO4

383816
type: SpeciesReference
stoichiometry: 1.0
species: 319326

319326
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: trans-Hexadec-2-enoyl carnitine_C23H43NO4

383310
type: SpeciesReference
stoichiometry: 1.0
species: 313389

383370
type: SpeciesReference
stoichiometry: 1.0
species: 329293

383491
type: SpeciesReference
stoichiometry: 1.0
species: 307283

383200
type: SpeciesReference
stoichiometry: 1.0
species: 315287

383442
type: SpeciesReference
stoichiometry: 1.0
species: 309840

309840
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: arachidyl carnitine_C27H53NO4

383053
type: SpeciesReference
stoichiometry: 1.0
species: 329824

383188
type: SpeciesReference
stoichiometry: 1.0
species: 327917

383611
type: SpeciesReference
stoichiometry: 1.0
species: 312050

383274
type: SpeciesReference
stoichiometry: 1.0
species: 309828

383164
type: SpeciesReference
stoichiometry: 1.0
species: 330706

383430
type: SpeciesReference
stoichiometry: 1.0
species: 307463

307463
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: R total carnitine_CO2FULLRC7H14NO2

383250
type: SpeciesReference
stoichiometry: 1.0
species: 307271

383224
type: SpeciesReference
stoichiometry: 1.0
species: 315251

383707
type: SpeciesReference
stoichiometry: 1.0
species: 307355

307355
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: R total 3 carnitine_CO2FULLR3C7H14NO2

383515
type: SpeciesReference
stoichiometry: 1.0
species: 329208

383114
type: SpeciesReference
stoichiometry: 1.0
species: 308837

383527
type: SpeciesReference
stoichiometry: 1.0
species: 319242

319242
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Hexadecenoyl carnitine_C23H43NO4

383418
type: SpeciesReference
stoichiometry: 1.0
species: 319638

383090
type: SpeciesReference
stoichiometry: 1.0
species: 325816

383077
type: SpeciesReference
stoichiometry: 1.0
species: 319230

383298
type: SpeciesReference
stoichiometry: 1.0
species: 329752

975311
type: Reaction
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
product: 412688
reactant: 412519
is: ENSRNOG00000015226.3
product: 412651
product: 412627
product: 412591
reactant: 412543
reactant: 412531
is: http://identifiers.org/ec-code/3.2.1.113
reactant: 412507
product: 412639
product: 412579
product: 412676
product: 412603
product: 412663
reactant: 412495
reactant: 412483
reactant: 412459
reactant: 412447
reversible: false
product: 412615
reactant: 412471
reactant: 412567
fast: false
reactant: 412555

412688
type: SpeciesReference
stoichiometry: 2.0
species: 323263

323263
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X

412519
type: SpeciesReference
stoichiometry: 1.0
species: 323359

323359
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X

412651
type: SpeciesReference
stoichiometry: 1.0
species: 323395

323395
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform A (protein)_C64H107N2O50X

412627
type: SpeciesReference
stoichiometry: 1.0
species: 323335

323335
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X

412591
type: SpeciesReference
stoichiometry: 1.0
species: 323275

323275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X

412543
type: SpeciesReference
stoichiometry: 2.0
species: 323347

323347
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X

412531
type: SpeciesReference
stoichiometry: 1.0
species: 323395

412507
type: SpeciesReference
stoichiometry: 1.0
species: 323335

412639
type: SpeciesReference
stoichiometry: 2.0
species: 323359

412579
type: SpeciesReference
stoichiometry: 3.0
species: 323227

323227
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)4-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C46H77N2O35X

412676
type: SpeciesReference
stoichiometry: 13.0
species: 323777

412603
type: SpeciesReference
stoichiometry: 1.0
species: 323287

323287
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)5-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C52H87N2O40X

412663
type: SpeciesReference
stoichiometry: 1.0
species: 323347

412495
type: SpeciesReference
stoichiometry: 13.0
species: 318870

412483
type: SpeciesReference
stoichiometry: 1.0
species: 323431

323431
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform C (protein)_C64H107N2O50X

412459
type: SpeciesReference
stoichiometry: 1.0
species: 323275

412447
type: SpeciesReference
stoichiometry: 2.0
species: 323407

323407
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)_C64H107N2O50X

412615
type: SpeciesReference
stoichiometry: 1.0
species: 323431

412471
type: SpeciesReference
stoichiometry: 1.0
species: 323287

412567
type: SpeciesReference
stoichiometry: 1.0
species: 323263

412555
type: SpeciesReference
stoichiometry: 2.0
species: 323467

323467
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C70H117N2O55X

312218
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate A (GalNAc4S-GlcA), degradation product 1_C45H68N2O43S2

976667
type: Reaction
product: 424669
notes: R_AACOAT subsystem: Propanoate Metabolism R_AACOAT equation: [c] : acac + atp + coa <==> aacoa + amp + ppi R_ACS2 subsystem: Propanoate Metabolism R_ACS2 equation: [c] : atp + coa + ppa --> amp + ppcoa + ppi R_ACS subsystem: Glycolysis/Gluconeogenesis R_ACS equation: [c] : ac + atp + coa --> accoa + amp + ppi
product: 424657
modifier: 424693
modifier: 424705
modifier: 424741
reversible: false
reactant: 424633
is: http://identifiers.org/ec-code/6.2.1.1
product: 424681
modifier: 424729
reactant: 424621
product: 424645
modifier: 424717
is: ENSRNOG00000000967.4
is: http://identifiers.org/ec-code/6.2.1.16
reactant: 424609
reactant: 424597
modifier: 424753
fast: false

424669
type: SpeciesReference
stoichiometry: 2.0
species: 309455

424657
type: SpeciesReference
stoichiometry: 1.0
species: 307825

307825
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetyl-CoA_C23H34N7O17P3S

424633
type: SpeciesReference
stoichiometry: 1.0
species: 327084

327084
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Propionate (n-C3:0)_C3H5O2

424681
type: SpeciesReference
stoichiometry: 2.0
species: 327157

307729
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetoacetate_C4H5O3

424621
type: SpeciesReference
stoichiometry: 2.0
species: 310142

424645
type: SpeciesReference
stoichiometry: 1.0
species: 327121

327121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Propanoyl-CoA_C24H36N7O17P3S

307608
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetoacetyl-CoA_C25H36N7O18P3S

424609
type: SpeciesReference
stoichiometry: 1.0
species: 307681

424597
type: SpeciesReference
stoichiometry: 2.0
species: 311759

326855
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: phytanic acid_C20H39O2

974662
type: Reaction
product: 407232
reactant: 407206
reactant: 407219
reversible: false
product: 407246
reactant: 407194
notes: R_OXAHCOtex subsystem: Transport, Extracellular R_OXAHCOtex equation: (2) hco3[c] + oxa[e] --> (2) hco3[e] + oxa[c] R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c]
fast: false
is: ENSRNOG00000000041.2
product: 407259

407232
type: SpeciesReference
stoichiometry: 1.0
species: 325962

325962
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Oxalate_C2O4

407206
type: SpeciesReference
stoichiometry: 1.0
species: 325974

325974
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Oxalate_C2O4

407219
type: SpeciesReference
stoichiometry: 1.0
species: 328905

407246
type: SpeciesReference
stoichiometry: 1.0
species: 328893

407194
type: SpeciesReference
stoichiometry: 4.0
species: 319110

407259
type: SpeciesReference
stoichiometry: 4.0
species: 319122

968662
type: Reaction
reactant: 349248
product: 349356
product: 349320
reversible: false
reactant: 349212
is: ENSRNOG00000014268.4
product: 349344
product: 349368
product: 349296
reactant: 349260
reactant: 349236
fast: false
is: http://identifiers.org/ec-code/6.4.1.2
product: 349284
product: 349308
reactant: 349224
notes: R_ACCOACm subsystem: Fatty Acid Metabolism R_ACCOACm equation: [m] : accoa + atp + hco3 --> adp + h + malcoa + pi R_ACCOAC subsystem: Fatty Acid Metabolism R_ACCOAC equation: [c] : accoa + atp + hco3 --> adp + h + malcoa + pi
product: 349332
reactant: 349272

349248
type: SpeciesReference
stoichiometry: 1.0
species: 307849

349356
type: SpeciesReference
stoichiometry: 1.0
species: 318954

349320
type: SpeciesReference
stoichiometry: 1.0
species: 308645

349212
type: SpeciesReference
stoichiometry: 1.0
species: 319134

349344
type: SpeciesReference
stoichiometry: 1.0
species: 308621

349368
type: SpeciesReference
stoichiometry: 1.0
species: 319002

349296
type: SpeciesReference
stoichiometry: 1.0
species: 326891

349260
type: SpeciesReference
stoichiometry: 1.0
species: 310166

349236
type: SpeciesReference
stoichiometry: 1.0
species: 310142

349284
type: SpeciesReference
stoichiometry: 1.0
species: 323625

323625
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Malonyl-CoA_C24H33N7O19P3S

349308
type: SpeciesReference
stoichiometry: 1.0
species: 326939

349224
type: SpeciesReference
stoichiometry: 1.0
species: 319110

349332
type: SpeciesReference
stoichiometry: 1.0
species: 323612

323612
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Malonyl-CoA_C24H33N7O19P3S

349272
type: SpeciesReference
stoichiometry: 1.0
species: 307825

313194
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dATP_C10H12N5O12P3

322519
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Leukotriene A4_C20H29O3

974626
type: Reaction
reactant: 406712
reactant: 406748
notes: R_PI4PLC subsystem: Inositol Phosphate Metabolism R_PI4PLC equation: [c] : h2o + pail4p_hs --> dag_hs + h + mi14p R_PI45PLC subsystem: Inositol Phosphate Metabolism R_PI45PLC equation: [c] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLC subsystem: Inositol Phosphate Metabolism R_PIPLC equation: [c] : h2o + pail_hs --> dag_hs + h + mi1p-D R_PI45PLCn subsystem: Inositol Phosphate Metabolism R_PI45PLCn equation: [n] : h2o + pail45p_hs --> dag_hs + h + mi145p R_PIPLCn subsystem: Inositol Phosphate Metabolism R_PIPLCn equation: [n] : h2o + pail_hs --> dag_hs + h + mi1p-D R_PI4PLCn subsystem: Inositol Phosphate Metabolism R_PI4PLCn equation: [n] : h2o + pail4p_hs --> dag_hs + h + mi14p
reactant: 406700
reactant: 406772
product: 406808
product: 406784
reversible: false
product: 406796
product: 406820
reactant: 406724
is: http://identifiers.org/ec-code/3.1.4.11
product: 406892
product: 406832
fast: false
reactant: 406687
product: 406868
reactant: 406760
is: ENSRNOG00000004810.4
is: http://identifiers.org/ec-code/3.1.4.3
product: 406844
reactant: 406736
product: 406856
product: 406880

406712
type: SpeciesReference
stoichiometry: 1.0
species: 326203

406748
type: SpeciesReference
stoichiometry: 1.0
species: 326240

326240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _1-Phosphatidyl-1D-myo-inositol 4-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2

406700
type: SpeciesReference
stoichiometry: 1.0
species: 326300

326300
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: phosphatidylinositol (homo sapiens)_C9H16O9PFULLRCO2FULLR2CO2

406772
type: SpeciesReference
stoichiometry: 3.0
species: 318906

406808
type: SpeciesReference
stoichiometry: 3.0
species: 319014

406784
type: SpeciesReference
stoichiometry: 3.0
species: 313110

406796
type: SpeciesReference
stoichiometry: 1.0
species: 324216

406820
type: SpeciesReference
stoichiometry: 1.0
species: 324229

324229
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _1D-myo-Inositol 1-phosphate_C6H11O9P

406724
type: SpeciesReference
stoichiometry: 1.0
species: 326288

406892
type: SpeciesReference
stoichiometry: 3.0
species: 318954

406832
type: SpeciesReference
stoichiometry: 1.0
species: 324204

324204
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _1D-myo-Inositol 1,4-bisphosphate_C6H10O12P2

406687
type: SpeciesReference
stoichiometry: 1.0
species: 326216

406868
type: SpeciesReference
stoichiometry: 1.0
species: 324168

406760
type: SpeciesReference
stoichiometry: 3.0
species: 318846

406844
type: SpeciesReference
stoichiometry: 3.0
species: 313134

313134
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: diacylglycerol (homo sapiens)_C3H6OFULLRCO2FULLR2CO2

406736
type: SpeciesReference
stoichiometry: 1.0
species: 326228

406856
type: SpeciesReference
stoichiometry: 1.0
species: 324180

406880
type: SpeciesReference
stoichiometry: 1.0
species: 324192

329013
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Sphingosine_C18H38NO2

305134
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Hydroxy-2-methylpropanoate_C4H7O3

970398
type: Reaction
product: 363826
is: ENSRNOG00000029528.2
reactant: 363790
product: 363838
reversible: false
reactant: 363778
reactant: 363802
notes: R_SELCYSTS subsystem: Selenoamino acid metabolism R_SELCYSTS equation: [c] : selhcys + ser-L --> h2o + selcyst R_CYSTS subsystem: Methionine Metabolism R_CYSTS equation: [c] : hcys-L + ser-L --> cyst-L + h2o
fast: false
product: 363814
is: http://identifiers.org/ec-code/4.2.1.22

363826
type: SpeciesReference
stoichiometry: 1.0
species: 328689

363790
type: SpeciesReference
stoichiometry: 2.0
species: 328773

363838
type: SpeciesReference
stoichiometry: 2.0
species: 318846

363778
type: SpeciesReference
stoichiometry: 1.0
species: 319158

363802
type: SpeciesReference
stoichiometry: 1.0
species: 328701

363814
type: SpeciesReference
stoichiometry: 1.0
species: 312966

312966
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Cystathionine_C7H14N2O4S

314379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4,8 dimethylnonanoyl-CoA_C32H54N7O17P3S

969587
type: Reaction
notes: R_KCCt subsystem: Transport, Extracellular R_KCCt equation: cl[e] + k[e] <==> cl[c] + k[c]
reversible: true
product: 356925
is: ENSRNOG00000018111.4
reactant: 356913
name: K+-Cl- cotransport
reactant: 356901
product: 356937
fast: false

356925
type: SpeciesReference
stoichiometry: 1.0
species: 320764

356913
type: SpeciesReference
stoichiometry: 1.0
species: 311448

356901
type: SpeciesReference
stoichiometry: 1.0
species: 320776

356937
type: SpeciesReference
stoichiometry: 1.0
species: 311436

319050
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: hyaluronan degradation product 1_C22H33N2O16

331127
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: UMP_C9H11N2O9P

305339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: (S)-3-Methyl-2-oxopentanoate_C6H9O3

314790
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763

974278
type: Reaction
notes: R_OXAHCOtex subsystem: Transport, Extracellular R_OXAHCOtex equation: (2) hco3[c] + oxa[e] --> (2) hco3[e] + oxa[c] R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c] R_CLHCOtex subsystem: Transport, Extracellular R_CLHCOtex equation: cl[e] + (2) hco3[c] --> cl[c] + (2) hco3[e]
product: 403294
product: 403331
product: 403306
product: 403318
reactant: 403257
reactant: 403270
is: ENSRNOG00000032215.2
reactant: 403245
reactant: 403282
reversible: false
is: ENSRNOG00000018082.2
fast: false

403294
type: SpeciesReference
stoichiometry: 1.0
species: 325962

403331
type: SpeciesReference
stoichiometry: 6.0
species: 319122

403306
type: SpeciesReference
stoichiometry: 1.0
species: 311436

403318
type: SpeciesReference
stoichiometry: 1.0
species: 328893

403257
type: SpeciesReference
stoichiometry: 1.0
species: 325974

403270
type: SpeciesReference
stoichiometry: 1.0
species: 328905

403245
type: SpeciesReference
stoichiometry: 6.0
species: 319110

403282
type: SpeciesReference
stoichiometry: 1.0
species: 311448

968469
type: Reaction
reactant: 347246
product: 347319
fast: false
notes: R_GASNASE2ly subsystem: N-Glycan Degradation R_GASNASE2ly equation: [l] : h2o + n2m2nmasn --> Asn-X-Ser/Thr + n2m2nm R_GASNASE3ly subsystem: Keratan sulfate degradation R_GASNASE3ly equation: [l] : h2o + ksi_deg1 --> Asn-X-Ser/Thr + ksi_deg2 R_GASNASEly subsystem: N-Glycan Degradation R_GASNASEly equation: [l] : h2o + s2l2n2m2masn --> Asn-X-Ser/Thr + s2l2n2m2m
reactant: 347258
product: 347294
product: 347332
reactant: 347282
reversible: false
product: 347307
is: ENSRNOG00000000108.3
is: http://identifiers.org/ec-code/3.5.1.26
reactant: 347270

347246
type: SpeciesReference
stoichiometry: 1.0
species: 324532

324532
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: N-Acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-(N-acetyl-beta-D-glucosaminyl-1,4)-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R_C58H96N5O40X

347319
type: SpeciesReference
stoichiometry: 1.0
species: 321077

321077
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 2_C241H384N17O210S12

347258
type: SpeciesReference
stoichiometry: 1.0
species: 328472

328472
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: de-Fuc form of PA6_C84H135N6O61X

347294
type: SpeciesReference
stoichiometry: 1.0
species: 324508

324508
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: n2m2nmasn (w/o peptide linkage)_C58H97N5O41

347332
type: SpeciesReference
stoichiometry: 1.0
species: 328448

328448
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: de-Fuc form of PA6 (w/o peptide linkage)_C84H136N6O62

347282
type: SpeciesReference
stoichiometry: 1.0
species: 320945

320945
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 1_C241H383N17O209S12X

347307
type: SpeciesReference
stoichiometry: 3.0
species: 306943

306943
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: protein-linked asparagine residue (N-glycosylation site)_XH

347270
type: SpeciesReference
stoichiometry: 3.0
species: 318882

318882
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: H2O_H2O

323443
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)7-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1720H2828N20O570P20

970240
type: Reaction
product: 362501
reactant: 362416
is: ENSRNOG00000008890.2
notes: R_ADRNLPVESSEC subsystem: Transport, Extracellular R_ADRNLPVESSEC equation: (3) adrnl[c] + (2) atp[c] + (2) h2o[c] --> (2) adp[c] + (3) adrnl[e] + (2) h[c] + (2) pi[c] R_5HTRPVESSEC subsystem: Transport, Extracellular R_5HTRPVESSEC equation: (3) 5htrp[c] + (2) atp[c] + (2) h2o[c] --> (3) 5htrp[e] + (2) adp[c] + (2) h[c] + (2) pi[c] R_NRPPHRVESSEC subsystem: Transport, Extracellular R_NRPPHRVESSEC equation: (2) atp[c] + (2) h2o[c] + (3) nrpphr[c] --> (2) adp[c] + (2) h[c] + (3) nrpphr[e] + (2) pi[c] R_HISTAVESSEC subsystem: Transport, Extracellular R_HISTAVESSEC equation: (2) atp[c] + (2) h2o[c] + (3) hista[c] --> (2) adp[c] + (2) h[c] + (3) hista[e] + (2) pi[c] R_DOPAVESSEC subsystem: Transport, Extracellular R_DOPAVESSEC equation: (2) atp[c] + (3) dopa[c] + (2) h2o[c] --> (2) adp[c] + (3) dopa[e] + (2) h[c] + (2) pi[c]
product: 362526
product: 362489
reactant: 362453
reactant: 362441
is: ENSRNOG00000011992.4
product: 362562
reactant: 362428
product: 362477
reactant: 362392
reactant: 362465
reversible: false
fast: false
product: 362538
product: 362550
product: 362513
reactant: 362404

362501
type: SpeciesReference
stoichiometry: 3.0
species: 314693

362416
type: SpeciesReference
stoichiometry: 10.0
species: 310142

362526
type: SpeciesReference
stoichiometry: 10.0
species: 308621

362489
type: SpeciesReference
stoichiometry: 3.0
species: 308875

308875
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Adrenaline_C9H14NO3

362453
type: SpeciesReference
stoichiometry: 3.0
species: 314681

314681
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dopamine_C8H12NO2

362441
type: SpeciesReference
stoichiometry: 3.0
species: 306439

306439
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Hydroxy-L-tryptophan_C11H12N2O3

362562
type: SpeciesReference
stoichiometry: 10.0
species: 318954

362428
type: SpeciesReference
stoichiometry: 3.0
species: 319470

362477
type: SpeciesReference
stoichiometry: 10.0
species: 326891

362392
type: SpeciesReference
stoichiometry: 3.0
species: 325247

325247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Norepinephrine_C8H12NO3

362465
type: SpeciesReference
stoichiometry: 10.0
species: 318846

362538
type: SpeciesReference
stoichiometry: 3.0
species: 325259

362550
type: SpeciesReference
stoichiometry: 3.0
species: 306451

306451
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _5-Hydroxy-L-tryptophan_C11H12N2O3

362513
type: SpeciesReference
stoichiometry: 3.0
species: 319482

319482
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Histamine_C5H10N3

362404
type: SpeciesReference
stoichiometry: 3.0
species: 308863

308863
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adrenaline_C9H14NO3

324254
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 3-phosphate_C6H11O9P

310951
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: CDP diacylglycerol (homo sapiens)_C12H17N3O11P2FULLRCO2FULLR2CO2

310818
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Cob(I)alamin_C62H88CoN13O14P

320548
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: IMP_C10H11N4O8P

317143
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N1-(5-Phospho-D-ribosyl)glycinamide_C7H14N2O8P

331441
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Valine_C5H11NO2

330161
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Thiamin triphosphate_C12H16N4O10P3S

973690
type: Reaction
product: 395819
fast: false
product: 395783
is: ENSRNOG00000010465.2
notes: R_S4T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S4T1g equation: [g] : cs_pre + (2) paps --> cs_a,b,e_pre1 + (2) h + (2) pap R_S4T6g subsystem: Chondroitin / heparan sulfate biosynthesis R_S4T6g equation: [g] : cs_b_pre4 + paps --> cs_b_pre5 + h + pap R_S4T3g subsystem: Chondroitin / heparan sulfate biosynthesis R_S4T3g equation: [g] : cs_e_pre4 + paps --> cs_e_pre5a + h + pap R_S4T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S4T2g equation: [g] : cs_a,b_pre3 + paps --> cspg_a + h + pap
reactant: 395759
product: 395795
product: 395807
reactant: 395747
product: 395831
is: ENSRNOG00000008885.4
reactant: 395771
reversible: false
reactant: 395735
product: 395843
is: http://identifiers.org/ec-code/2.8.2.5
reactant: 395723

395819
type: SpeciesReference
stoichiometry: 1.0
species: 312736

312736
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 5a_C45H64N2O51S5X

395783
type: SpeciesReference
stoichiometry: 1.0
species: 312796

312796
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan_C45H66N2O45S3X

395759
type: SpeciesReference
stoichiometry: 1.0
species: 312724

312724
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 4_C45H65N2O48S4X

395795
type: SpeciesReference
stoichiometry: 5.0
species: 318978

395807
type: SpeciesReference
stoichiometry: 1.0
species: 312182

312182
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate A (GalNAc4S-GlcA), B (IdoA2S-GalNAc4S), and E (GalNAc4,6diS-GlcA), precursor 1_C31H47NO31S2X

395747
type: SpeciesReference
stoichiometry: 1.0
species: 312206

312206
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 3_C45H67N2O42S2X

395831
type: SpeciesReference
stoichiometry: 5.0
species: 326361

395771
type: SpeciesReference
stoichiometry: 1.0
species: 312760

312760
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate precursor (GalNAc-GlcA-(Gal)2-Xyl-L-Ser (protein))_C31H49NO25X

395735
type: SpeciesReference
stoichiometry: 5.0
species: 326385

395843
type: SpeciesReference
stoichiometry: 1.0
species: 312351

312351
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate B (IdoA2S-GalNAc4s), precursor 5_C45H66N2O45S3X

395723
type: SpeciesReference
stoichiometry: 1.0
species: 312339

312339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate B (IdoA2S-GalNAc4S), precursor 4_C45H67N2O42S2X

309347
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: lysophosphatidic acid (homo sapiens)_C3H6O5PFULLRCO2

313086
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dADP_C10H12N5O9P2

311508
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: clupanodonyl CoA_C43H64N7O17P3S

976835
type: Reaction
reactant: 427708
is: http://identifiers.org/ec-code/2.4.2.2
fast: false
product: 427770
is: ENSRNOG00000005341.4
notes: R_DURIPP subsystem: Nucleotides R_DURIPP equation: [c] : duri + pi <==> 2dr1p + ura R_PYNP2r subsystem: Pyrimidine Catabolism R_PYNP2r equation: [c] : pi + uri <==> r1p + ura
product: 427745
reactant: 427733
reactant: 427721
reversible: true
product: 427757

427708
type: SpeciesReference
stoichiometry: 1.0
species: 315022

427770
type: SpeciesReference
stoichiometry: 2.0
species: 331187

331187
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Uracil_C4H4N2O2

427745
type: SpeciesReference
stoichiometry: 1.0
species: 304593

304593
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Deoxy-D-ribose 1-phosphate_C5H9O7P

427733
type: SpeciesReference
stoichiometry: 1.0
species: 331272

427721
type: SpeciesReference
stoichiometry: 2.0
species: 326891

427757
type: SpeciesReference
stoichiometry: 1.0
species: 328169

328169
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-D-Ribose 1-phosphate_C5H9O8P

313158
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dAMP_C10H12N5O6P

967604
type: Reaction
is: ENSRNOG00000014369.4
is: ENSRNOG00000018170.3
notes: R_FATP3t subsystem: Transport, Extracellular R_FATP3t equation: na1[c] + ocdca[c] <==> na1[e] + ocdca[e] R_FATP1t subsystem: Transport, Extracellular R_FATP1t equation: hdca[c] + na1[c] <==> hdca[e] + na1[e] R_FATP2t subsystem: Transport, Extracellular R_FATP2t equation: na1[c] + ocdcea[c] <==> na1[e] + ocdcea[e]
reactant: 339123
product: 339159
product: 339184
product: 339171
reactant: 339147
reactant: 339111
reversible: true
reactant: 339135
product: 339196
fast: false

339123
type: SpeciesReference
stoichiometry: 1.0
species: 325658

339159
type: SpeciesReference
stoichiometry: 1.0
species: 325695

325695
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: octadecenoate (n-C18:1)_C18H33O2

339184
type: SpeciesReference
stoichiometry: 3.0
species: 324628

339171
type: SpeciesReference
stoichiometry: 1.0
species: 319182

319182
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Hexadecanoate (n-C16:0)_C16H31O2

339147
type: SpeciesReference
stoichiometry: 3.0
species: 324616

339111
type: SpeciesReference
stoichiometry: 1.0
species: 319170

339135
type: SpeciesReference
stoichiometry: 1.0
species: 325683

339196
type: SpeciesReference
stoichiometry: 1.0
species: 325671

325671
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: octadecanoate (n-C18:0)_C18H35O2

306859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: heptaglutamyl folate (DHF)_C49H55N13O24

973041
type: Reaction
product: 389177
is: http://identifiers.org/ec-code/1.1.1.35
reactant: 389141
notes: R_HACD1m subsystem: Tryptophan metabolism R_HACD1m equation: [m] : aacoa + h + nadh <==> 3hbcoa + nad
name: _3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA) (mitochondria)
reversible: true
reactant: 389153
is: ENSRNOG00000010697.2
fast: false
product: 389189
reactant: 389165

389177
type: SpeciesReference
stoichiometry: 1.0
species: 305085

389141
type: SpeciesReference
stoichiometry: 1.0
species: 307620

389153
type: SpeciesReference
stoichiometry: 1.0
species: 319002

389189
type: SpeciesReference
stoichiometry: 1.0
species: 324700

389165
type: SpeciesReference
stoichiometry: 1.0
species: 324761

331878
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane_C27H48O3

318690
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: GTP_C10H12N5O14P3

315516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: estrone glucuronide_C24H30O8

968397
type: Reaction
product: 346846
fast: false
product: 346858
product: 346870
is: ENSRNOG00000000588.3
notes: R_PHEtec subsystem: Transport, Extracellular R_PHEtec equation: phe-L[e] <==> phe-L[c] R_TYRt subsystem: Transport, Extracellular R_TYRt equation: tyr-L[e] <==> tyr-L[c] R_TRPt subsystem: Transport, Extracellular R_TRPt equation: trp-L[e] <==> trp-L[c] R_34DHPHEt subsystem: Transport, Extracellular R_34DHPHEt equation: _34dhphe[e] <==> 34dhphe[c]
product: 346834
reactant: 346797
reactant: 346785
reactant: 346821
reversible: true
reactant: 346809

346846
type: SpeciesReference
stoichiometry: 1.0
species: 330766

330766
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Tyrosine_C9H11NO3

346858
type: SpeciesReference
stoichiometry: 1.0
species: 330526

346870
type: SpeciesReference
stoichiometry: 1.0
species: 326723

346834
type: SpeciesReference
stoichiometry: 1.0
species: 304845

304845
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3,4-Dihydroxy-L-phenylalanine_C9H11NO4

346797
type: SpeciesReference
stoichiometry: 1.0
species: 304857

304857
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _3,4-Dihydroxy-L-phenylalanine_C9H11NO4

346785
type: SpeciesReference
stoichiometry: 1.0
species: 330538

330538
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Tryptophan_C11H12N2O2

346821
type: SpeciesReference
stoichiometry: 1.0
species: 326735

346809
type: SpeciesReference
stoichiometry: 1.0
species: 330778

330778
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Tyrosine_C9H11NO3

311893
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Core 6_C16H27N2O10X

310492
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Biotinyl-5'-AMP_C20H27N7O9PS

967278
type: Reaction
is: ENSRNOG00000017180.4
product: 336353
name: phosphate transport in/out via three Na+ symporter (irreversible)
notes: R_PIt7ir subsystem: Transport, Extracellular R_PIt7ir equation: (3) na1[e] + pi[e] --> (3) na1[c] + pi[c]
fast: false
is: ENSRNOG00000018554.3
is: ENSRNOG00000022505.3
is: ENSRNOG00000032745.2
reactant: 336328
reactant: 336316
product: 336341
reversible: false
is: ENSRNOG00000010007.3

336353
type: SpeciesReference
stoichiometry: 3.0
species: 324616

336328
type: SpeciesReference
stoichiometry: 3.0
species: 324628

336316
type: SpeciesReference
stoichiometry: 1.0
species: 326903

336341
type: SpeciesReference
stoichiometry: 1.0
species: 326891

331502
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: w-hydroxyl arachidonic acid_C20H31O3

317035
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: galactosyl glucosyl ceramide_C30H56NO12FULLRCO

318148
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: glycogen, structure 5 (glycogenin-2[1,4-Glc])_C12H21O11X

326687
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylglycerol (homo sapiens)_C6H12O6PFULLRCO2FULLR2CO2

973582
type: Reaction
reactant: 394656
reactant: 394680
product: 394716
reactant: 394668
reactant: 394643
is: ENSRNOG00000019264.3
fast: false
notes: R_AKR1D2 subsystem: Bile Acid Biosynthesis R_AKR1D2 equation: [c] : h + nadph + xoldiolone --> nadp + xoldioloneh R_AKR1D subsystem: Bile Acid Biosynthesis R_AKR1D equation: [c] : h + nadph + xol7aone --> nadp + xol7ah
product: 394704
reversible: false
product: 394692

394656
type: SpeciesReference
stoichiometry: 1.0
species: 331719

331719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _7alpha-Hydroxycholest-4-en-3-one_C27H44O2

394680
type: SpeciesReference
stoichiometry: 2.0
species: 324869

394716
type: SpeciesReference
stoichiometry: 1.0
species: 331767

331767
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one_C27H46O3

394668
type: SpeciesReference
stoichiometry: 2.0
species: 318954

394643
type: SpeciesReference
stoichiometry: 1.0
species: 331743

331743
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _7alpha,12alpha-Dihydroxycholest-4-en-3-one_C27H44O3

394704
type: SpeciesReference
stoichiometry: 2.0
species: 324797

394692
type: SpeciesReference
stoichiometry: 1.0
species: 331706

330125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Thiamin monophosphate_C12H16N4O4PS

322094
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: keratan sulfate II (core 4-linked)_C89H142N7O72S3X

304617
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Hydroxybutyrate_C4H7O3

308151
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: nLc7Cer_C66H115N4O37FULLRCO

312579
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 4_C45H66N2O45S3X

327543
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: D-Proline_C5H9NO2

310673
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

972897
type: Reaction
is: http://identifiers.org/ec-code/2.7.1.52
is: ENSRNOG00000017794.4
fast: false
reversible: false
name: Fucokinase
product: 388058
notes: R_FK subsystem: Fructose and Mannose Metabolism R_FK equation: [c] : atp + fuc-L --> adp + fuc1p-L + h
product: 388045
reactant: 388019
reactant: 388006
product: 388032

388058
type: SpeciesReference
stoichiometry: 1.0
species: 318954

388045
type: SpeciesReference
stoichiometry: 1.0
species: 308621

388019
type: SpeciesReference
stoichiometry: 1.0
species: 316250

316250
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Fucose_C6H12O5

388006
type: SpeciesReference
stoichiometry: 1.0
species: 310142

388032
type: SpeciesReference
stoichiometry: 1.0
species: 316237

316237
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Fucose 1-phosphate_C6H11O8P

974722
type: Reaction
fast: false
product: 407673
name: Uncoupling protein
notes: R_Htm subsystem: Transport, Mitochondrial R_Htm equation: h[c] --> h[m]
is: ENSRNOG00000010592.3
is: ENSRNOG00000006871.3
is: ENSRNOG00000003580.3
is: ENSRNOG00000017716.3
reversible: false
is: ENSRNOG00000017854.3
reactant: 407661

407673
type: SpeciesReference
stoichiometry: 1.0
species: 319002

407661
type: SpeciesReference
stoichiometry: 1.0
species: 318954

310975
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Cys-Gly_C5H10N2O3S

977303
type: Reaction
product: 432129
fast: false
is: http://identifiers.org/ec-code/1.8.1.9
reactant: 432069
notes: R_TRDR subsystem: Nucleotides R_TRDR equation: [c] : h + nadph + trdox --> nadp + trdrd R_TRDR2 subsystem: Miscellaneous R_TRDR2 equation: [c] : h + nadph + q10 --> nadp + q10h2 R_TRDR3 subsystem: Miscellaneous R_TRDR3 equation: [c] : h + nadh + q10 --> nad + q10h2
product: 432141
product: 432117
reactant: 432093
reactant: 432081
product: 432105
is: ENSRNOG00000009088.4
reversible: false
reactant: 432057
reactant: 432045

432129
type: SpeciesReference
stoichiometry: 1.0
species: 324676

432069
type: SpeciesReference
stoichiometry: 1.0
species: 324749

432141
type: SpeciesReference
stoichiometry: 2.0
species: 324797

432117
type: SpeciesReference
stoichiometry: 1.0
species: 330441

432093
type: SpeciesReference
stoichiometry: 2.0
species: 324869

432081
type: SpeciesReference
stoichiometry: 2.0
species: 328109

328109
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Ubiquinone-10_C59H90O4

432105
type: SpeciesReference
stoichiometry: 2.0
species: 328133

432057
type: SpeciesReference
stoichiometry: 3.0
species: 318954

432045
type: SpeciesReference
stoichiometry: 1.0
species: 330417

330417
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Oxidized thioredoxin_X

313461
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Deoxycytidine_C9H13N3O4

976607
type: Reaction
product: 423761
reactant: 423749
notes: R_PHEMEt subsystem: Transport, Extracellular R_PHEMEt equation: pheme[e] --> pheme[c]
is: ENSRNOG00000010291.4
fast: false
reversible: false
name: heme transport

423761
type: SpeciesReference
stoichiometry: 1.0
species: 326759

326759
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Protoheme_C34H30FeN4O4

423749
type: SpeciesReference
stoichiometry: 1.0
species: 326771

326771
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Protoheme_C34H30FeN4O4

304917
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: _3',5'-Cyclic GMP_C10H11N5O7P

331950
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Xylulose 5-phosphate_C5H9O8P

323107
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Lysine_C6H15N2O2

969807
type: Reaction
reactant: 359182
is: ENSRNOG00000029465.2
reversible: false
is: ENSRNOG00000039461.1
reactant: 359134
product: 359278
product: 359206
reactant: 359158
product: 359254
fast: false
reactant: 359170
notes: R_CLOXAtex2 subsystem: Transport, Extracellular R_CLOXAtex2 equation: (2) cl[e] + oxa[c] --> (2) cl[c] + oxa[e] R_SO4CLtex2 subsystem: Transport, Extracellular R_SO4CLtex2 equation: cl[c] + (2) so4[e] --> cl[e] + (2) so4[c] R_SO4OXAtex2 subsystem: Transport, Extracellular R_SO4OXAtex2 equation: oxa[c] + (2) so4[e] --> oxa[e] + (2) so4[c] R_CLFORtex2 subsystem: Transport, Extracellular R_CLFORtex2 equation: (2) cl[e] + for[c] --> (2) cl[c] + for[e] R_CLOHtex2 subsystem: Transport, Extracellular R_CLOHtex2 equation: (2) cl[e] + oh1[c] --> (2) cl[c] + oh1[e] R_CLHCO3tex2 subsystem: Transport, Extracellular R_CLHCO3tex2 equation: (2) cl[e] + hco3[c] --> (2) cl[c] + hco3[e]
product: 359266
is: ENSRNOG00000020450.4
is: ENSRNOG00000034005.1
reactant: 359146
reactant: 359194
product: 359230
reactant: 359122
product: 359242
product: 359218

359182
type: SpeciesReference
stoichiometry: 1.0
species: 325841

325841
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: hydroxide ion_HO

359134
type: SpeciesReference
stoichiometry: 1.0
species: 319110

359278
type: SpeciesReference
stoichiometry: 1.0
species: 311448

359206
type: SpeciesReference
stoichiometry: 1.0
species: 316033

316033
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Formate_CH1O2

359158
type: SpeciesReference
stoichiometry: 1.0
species: 311436

359254
type: SpeciesReference
stoichiometry: 4.0
species: 328893

359170
type: SpeciesReference
stoichiometry: 4.0
species: 328905

359266
type: SpeciesReference
stoichiometry: 1.0
species: 319122

359146
type: SpeciesReference
stoichiometry: 1.0
species: 316021

316021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Formate_CH1O2

359194
type: SpeciesReference
stoichiometry: 8.0
species: 311448

359230
type: SpeciesReference
stoichiometry: 8.0
species: 311436

359122
type: SpeciesReference
stoichiometry: 2.0
species: 325962

359242
type: SpeciesReference
stoichiometry: 1.0
species: 325853

359218
type: SpeciesReference
stoichiometry: 2.0
species: 325974

970215
type: Reaction
reversible: false
product: 362282
reactant: 362101
product: 362258
product: 362174
reactant: 362089
product: 362234
product: 362270
reactant: 362125
product: 362198
reactant: 362137
fast: false
is: ENSRNOG00000014645.4
reactant: 362017
reactant: 362041
reactant: 362149
notes: R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
reactant: 362029
reactant: 362053
product: 362246
product: 362162
product: 362222
reactant: 362065
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 362113
is: http://identifiers.org/ec-code/1.2.1.21
product: 362210
product: 362294
product: 362186
reactant: 362077

362282
type: SpeciesReference
stoichiometry: 20.0
species: 318954

362101
type: SpeciesReference
stoichiometry: 1.0
species: 310239

310239
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: beta-Aminopropion aldehyde_C3H8NO

362258
type: SpeciesReference
stoichiometry: 1.0
species: 309166

362174
type: SpeciesReference
stoichiometry: 1.0
species: 318052

362089
type: SpeciesReference
stoichiometry: 1.0
species: 307777

362234
type: SpeciesReference
stoichiometry: 1.0
species: 322323

362270
type: SpeciesReference
stoichiometry: 1.0
species: 322287

362125
type: SpeciesReference
stoichiometry: 1.0
species: 320356

320356
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Indole-3-acetaldehyde_C10H9NO

362198
type: SpeciesReference
stoichiometry: 1.0
species: 307681

362137
type: SpeciesReference
stoichiometry: 10.0
species: 318846

362017
type: SpeciesReference
stoichiometry: 1.0
species: 322386

362041
type: SpeciesReference
stoichiometry: 1.0
species: 320512

320512
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Imidazole-4-acetaldehyde_C5H6N2O

362149
type: SpeciesReference
stoichiometry: 1.0
species: 322361

362029
type: SpeciesReference
stoichiometry: 1.0
species: 324580

324580
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N4-Acetylaminobutanal_C6H11NO2

362053
type: SpeciesReference
stoichiometry: 1.0
species: 328037

328037
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Perillyl aldehyde_C10H14O

362246
type: SpeciesReference
stoichiometry: 1.0
species: 326651

326651
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Perillic acid_C10H13O2

362162
type: SpeciesReference
stoichiometry: 1.0
species: 320488

320488
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Imidazole-4-acetate_C5H5N2O2

362222
type: SpeciesReference
stoichiometry: 1.0
species: 306403

306403
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Hydroxyindoleacetate_C10H8NO3

362065
type: SpeciesReference
stoichiometry: 10.0
species: 324676

362113
type: SpeciesReference
stoichiometry: 1.0
species: 306379

306379
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Hydroxyindoleacetaldehyde_C10H9NO2

362210
type: SpeciesReference
stoichiometry: 1.0
species: 305653

305653
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Acetamidobutanoate_C6H10NO3

362294
type: SpeciesReference
stoichiometry: 10.0
species: 324749

362186
type: SpeciesReference
stoichiometry: 1.0
species: 320560

320560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Indole-3-acetate_C10H8NO2

362077
type: SpeciesReference
stoichiometry: 1.0
species: 317180

307137
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Histone N6-methyl-L-lysine_CXH4

310130
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Aspartate_C4H6NO4

305231
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Iodo-L-tyrosine_C9H10INO3

973918
type: Reaction
is: ENSRNOG00000019560.4
notes: R_PDE1 subsystem: Nucleotides R_PDE1 equation: [c] : camp + h2o --> amp + h R_PDE4 subsystem: Nucleotides R_PDE4 equation: [c] : 35cgmp + h2o --> gmp + h
is: ENSRNOG00000036828.1
is: ENSRNOG00000012337.4
is: ENSRNOG00000025042.1
is: ENSRNOG00000011417.3
reactant: 398731
fast: false
product: 398755
is: http://identifiers.org/ec-code/3.1.4.17
reactant: 398719
product: 398743
product: 398767
reactant: 398707
is: ENSRNOG00000024457.2
is: ENSRNOG00000006154.4
reversible: false

398731
type: SpeciesReference
stoichiometry: 2.0
species: 318846

398755
type: SpeciesReference
stoichiometry: 1.0
species: 309455

398719
type: SpeciesReference
stoichiometry: 1.0
species: 304893

398743
type: SpeciesReference
stoichiometry: 1.0
species: 318234

398767
type: SpeciesReference
stoichiometry: 2.0
species: 318954

398707
type: SpeciesReference
stoichiometry: 1.0
species: 310733

310733
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cAMP_C10H11N5O6P

324893
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3

970951
type: Reaction
product: 369191
reactant: 369179
notes: R_RPE subsystem: Pentose Phosphate Pathway R_RPE equation: [c] : ru5p-D <==> xu5p-D
is: ENSRNOG00000038085.1
is: http://identifiers.org/ec-code/5.1.3.1
fast: false
reversible: true
name: ribulose 5-phosphate 3-epimerase

369191
type: SpeciesReference
stoichiometry: 1.0
species: 331950

369179
type: SpeciesReference
stoichiometry: 1.0
species: 328388

328388
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Ribulose 5-phosphate_C5H9O8P

305436
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _3-Oxohexacosyl-CoA_C47H80N7O18P3S

320028
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 12_C79H119N5O83S6X

325986
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Oxalate_C2O4

317410
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763

328520
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: sialyl-T antigen_C25H40N2O18X

968072
type: Reaction
is: ENSRNOG00000032445.1
notes: R_NADH2_DASH_u10m subsystem: Oxidative Phosphorylation R_NADH2_DASH_u10m equation: (5) h[m] + nadh[m] + q10[m] --> (4) h[c] + nad[m] + q10h2[m]
is: ENSRNOG00000014568.4
is: ENSRNOG00000011383.3
is: ENSRNOG00000001182.4
is: ENSRNOG00000021688.3
reactant: 343126
is: ENSRNOG00000034289.1
is: ENSRNOG00000022574.3
is: ENSRNOG00000040005.1
is: ENSRNOG00000011849.4
is: ENSRNOG00000012383.3
is: ENSRNOG00000006939.4
is: http://identifiers.org/ec-code/1.6.99.3
is: ENSRNOG00000026930.3
product: 343162
reactant: 343101
is: ENSRNOG00000032733.2
is: ENSRNOG00000037184.1
is: ENSRNOG00000018117.3
is: ENSRNOG00000023387.3
is: ENSRNOG00000016470.4
reversible: false
is: ENSRNOG00000025242.2
is: ENSRNOG00000018129.4
is: ENSRNOG00000009364.4
is: ENSRNOG00000017446.4
is: ENSRNOG00000013061.3
product: 343150
is: ENSRNOG00000038372.1
product: 343138
is: ENSRNOG00000005512.2
reactant: 343113
fast: false
is: ENSRNOG00000031321.1
is: ENSRNOG00000029339.1
is: ENSRNOG00000027593.1
is: ENSRNOG00000024539.3
is: ENSRNOG00000028717.3
is: ENSRNOG00000008569.3
is: ENSRNOG00000026646.3
is: ENSRNOG00000006660.2
is: ENSRNOG00000011949.4
is: ENSRNOG00000005668.4
is: ENSRNOG00000000913.4
is: ENSRNOG00000032758.2
is: ENSRNOG00000002721.4
is: ENSRNOG00000037052.1
is: ENSRNOG00000026616.3
is: ENSRNOG00000038218.1
name: NADH dehydrogenase, mitochondrial
is: ENSRNOG00000030959.1
is: ENSRNOG00000030301.1
is: ENSRNOG00000028492.3
is: ENSRNOG00000030089.1
is: ENSRNOG00000017571.4
is: ENSRNOG00000014078.4
is: ENSRNOG00000034182.2
is: ENSRNOG00000020602.4
is: ENSRNOG00000007407.4
is: ENSRNOG00000018068.3
is: ENSRNOG00000011825.4
is: ENSRNOG00000030585.2
is: ENSRNOG00000009155.4

343126
type: SpeciesReference
stoichiometry: 1.0
species: 324761

343162
type: SpeciesReference
stoichiometry: 4.0
species: 318954

343101
type: SpeciesReference
stoichiometry: 1.0
species: 328121

343150
type: SpeciesReference
stoichiometry: 1.0
species: 324700

343138
type: SpeciesReference
stoichiometry: 1.0
species: 328145

343113
type: SpeciesReference
stoichiometry: 5.0
species: 319002

970143
type: Reaction
is: ENSRNOG00000014405.4
reactant: 361654
reactant: 361642
product: 361678
is: http://identifiers.org/ec-code/2.4.2.7
fast: false
product: 361666
notes: R_ADPT subsystem: Salvage Pathway R_ADPT equation: [c] : ade + prpp --> amp + ppi
reversible: false
name: adenine phosphoribosyltransferase

361654
type: SpeciesReference
stoichiometry: 1.0
species: 327821

361642
type: SpeciesReference
stoichiometry: 1.0
species: 308500

308500
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adenine_C5H5N5

361678
type: SpeciesReference
stoichiometry: 1.0
species: 327157

361666
type: SpeciesReference
stoichiometry: 1.0
species: 309455

308259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Acetylcholine_C7H16NO2

312954
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Cysteamine_C2H8NS

972669
type: Reaction
product: 386595
reactant: 386583
is: ENSRNOG00000011182.4
reactant: 386571
notes: R_SRTNACT subsystem: Tryptophan metabolism R_SRTNACT equation: [c] : accoa + srtn --> Nacsertn + coa + h R_CHSTEROLtg subsystem: Transport, Golgi Apparatus R_CHSTEROLtg equation: atp[c] + chsterol[g] + h2o[c] --> adp[c] + chsterol[c] + h[c] + pi[c] R_CHSTEROLt subsystem: Transport, Extracellular R_CHSTEROLt equation: atp[c] + chsterol[c] + h2o[c] --> adp[c] + chsterol[e] + h[c] + pi[c]
product: 386667
reversible: false
reactant: 386523
reactant: 386547
product: 386643
product: 386607
reactant: 386535
product: 386631
fast: false
product: 386655
product: 386619
reactant: 386559
is: http://identifiers.org/ec-code/2.3.1.87

386595
type: SpeciesReference
stoichiometry: 1.0
species: 311759

386583
type: SpeciesReference
stoichiometry: 1.0
species: 311279

311279
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Cholesterol_C27H46O

386571
type: SpeciesReference
stoichiometry: 2.0
species: 318846

386667
type: SpeciesReference
stoichiometry: 3.0
species: 318954

386523
type: SpeciesReference
stoichiometry: 2.0
species: 310142

386547
type: SpeciesReference
stoichiometry: 1.0
species: 329135

329135
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Serotonin_C10H13N2O

386643
type: SpeciesReference
stoichiometry: 2.0
species: 308621

386607
type: SpeciesReference
stoichiometry: 2.0
species: 326891

386535
type: SpeciesReference
stoichiometry: 1.0
species: 311255

311255
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Cholesterol_C27H46O

386631
type: SpeciesReference
stoichiometry: 1.0
species: 307113

307113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetylserotonin_C12H14N2O2

386655
type: SpeciesReference
stoichiometry: 1.0
species: 311255

386619
type: SpeciesReference
stoichiometry: 1.0
species: 311267

311267
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Cholesterol_C27H46O

386559
type: SpeciesReference
stoichiometry: 1.0
species: 307825

969891
type: Reaction
product: 359857
is: ENSRNOG00000021347.3
is: ENSRNOG00000037974.1
reactant: 359809
reactant: 359797
product: 359821
reversible: true
is: http://identifiers.org/ec-code/3.5.4.9
fast: false
product: 359833
reactant: 359773
reactant: 359785
notes: R_MTHFD2 subsystem: Folate Metabolism R_MTHFD2 equation: [c] : mlthf + nad <==> methf + nadh R_MTHFC subsystem: Folate Metabolism R_MTHFC equation: [c] : h2o + methf <==> 10fthf + h
product: 359845
is: http://identifiers.org/ec-code/1.5.1.5

359857
type: SpeciesReference
stoichiometry: 1.0
species: 324749

359809
type: SpeciesReference
stoichiometry: 1.0
species: 318846

359797
type: SpeciesReference
stoichiometry: 1.0
species: 324011

324011
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5,10-Methenyltetrahydrofolate_C20H20N7O6

359821
type: SpeciesReference
stoichiometry: 1.0
species: 324011

359833
type: SpeciesReference
stoichiometry: 1.0
species: 318954

359773
type: SpeciesReference
stoichiometry: 1.0
species: 324302

324302
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5,10-Methylenetetrahydrofolate_C20H21N7O6

359785
type: SpeciesReference
stoichiometry: 1.0
species: 324676

359845
type: SpeciesReference
stoichiometry: 1.0
species: 304004

305776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _4-Hydroxy-2-oxoglutarate_C5H4O6

306775
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: hexaglutamyl folate (THF)_C44H51N12O21

323673
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Maltose_C12H22O11

330149
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Thiamin triphosphate_C12H16N4O10P3S

319146
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: hydroxy coumarin_C9H6O3

305942
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4 hydroxy tolbutamide_C12H18N2O4S

314042
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _7,8-Dihydrofolate_C19H19N7O6

317373
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GDP_C10H12N5O11P2

317931
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glyceraldehyde_C3H6O3

326517
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: propionyl-carnitine_C10H19NO4

331974
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Xylose_C5H10O5

306343
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _5-Formyltetrahydrofolate_C20H21N7O7

303883
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: _10-formyltetrahydrofolate-[Glu](5)_C40H45N11O19

327278
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Protoporphyrinogen IX_C34H38N4O4

967134
type: Reaction
fast: false
reactant: 335255
reactant: 335231
product: 335316
product: 335304
notes: R_MAN1_7Ber subsystem: N-Glycan Biosynthesis R_MAN1_7Ber equation: [r] : g1m8masn + h2o --> g1m7masnB + man R_MAN1_6B1er subsystem: N-Glycan Biosynthesis R_MAN1_6B1er equation: [r] : g1m7masnC + h2o --> g1m6masnB1 + man R_MM8Ber subsystem: N-Glycan Biosynthesis R_MM8Ber equation: [r] : h2o + m8masn --> m7masnB + man
reactant: 335243
is: ENSRNOG00000012559.4
product: 335292
reversible: false
product: 335280
is: http://identifiers.org/ec-code/3.2.1.113
reactant: 335268

335255
type: SpeciesReference
stoichiometry: 3.0
species: 318918

335231
type: SpeciesReference
stoichiometry: 1.0
species: 323479

323479
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C70H117N2O55X

335316
type: SpeciesReference
stoichiometry: 1.0
species: 323419

323419
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)_C64H107N2O50X

335304
type: SpeciesReference
stoichiometry: 1.0
species: 316540

316540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glucosyl-(alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C64H107N2O50X

335243
type: SpeciesReference
stoichiometry: 1.0
species: 316564

335292
type: SpeciesReference
stoichiometry: 1.0
species: 316552

316552
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glucosyl-(alpha-D-mannosyl)7-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine, isoform B (protein)_C70H117N2O55X

335280
type: SpeciesReference
stoichiometry: 3.0
species: 323803

323803
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: D-Mannose_C6H12O6

335268
type: SpeciesReference
stoichiometry: 1.0
species: 316576

316576
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C76H127N2O60X

323311
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)5-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1545H2540N20O470P20

968301
type: Reaction
reactant: 345556
product: 345628
product: 345616
product: 345604
reactant: 345580
is: ENSRNOG00000003049.4
fast: false
notes: R_HACD1m subsystem: Tryptophan metabolism R_HACD1m equation: [m] : aacoa + h + nadh <==> 3hbcoa + nad R_HACD9m subsystem: Valine, Leucine, and Isoleucine Metabolism R_HACD9m equation: [m] : 3hmbcoa + nad <==> 2maacoa + h + nadh
product: 345652
product: 345640
reactant: 345592
reactant: 345544
reversible: true
reactant: 345568
is: http://identifiers.org/ec-code/1.1.1.35

345556
type: SpeciesReference
stoichiometry: 1.0
species: 324700

345628
type: SpeciesReference
stoichiometry: 1.0
species: 324700

345616
type: SpeciesReference
stoichiometry: 1.0
species: 304653

345604
type: SpeciesReference
stoichiometry: 1.0
species: 305085

345580
type: SpeciesReference
stoichiometry: 1.0
species: 319002

345652
type: SpeciesReference
stoichiometry: 1.0
species: 324761

345640
type: SpeciesReference
stoichiometry: 1.0
species: 319002

345592
type: SpeciesReference
stoichiometry: 1.0
species: 324761

345544
type: SpeciesReference
stoichiometry: 1.0
species: 307620

345568
type: SpeciesReference
stoichiometry: 1.0
species: 305122

305955
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _4-Methylzymosterol intermediate 1_C29H46O3

312495
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), degradation product 3_C37H54NO41S3

977339
type: Reaction
reactant: 432480
is: ENSRNOG00000009625.4
fast: false
name: dihydropyrimidinase (5,6-dihydrouracil)
is: http://identifiers.org/ec-code/3.5.2.2
product: 432516
product: 432504
reactant: 432492
notes: R_DHPM1 subsystem: Pyrimidine Catabolism R_DHPM1 equation: [c] : 56dura + h2o --> cala + h
is: ENSRNOG00000018992.4
is: ENSRNOG00000004298.3
reversible: false

432480
type: SpeciesReference
stoichiometry: 1.0
species: 306113

432516
type: SpeciesReference
stoichiometry: 1.0
species: 318954

432504
type: SpeciesReference
stoichiometry: 1.0
species: 310721

432492
type: SpeciesReference
stoichiometry: 1.0
species: 318846

320113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 4_C51H76N2O42X

976199
type: Reaction
product: 420224
reactant: 420212
notes: R_ACGAM2E subsystem: Aminosugar Metabolism R_ACGAM2E equation: [c] : acgam <==> acmana
is: ENSRNOG00000037267.1
is: http://identifiers.org/ec-code/5.1.3.8
fast: false
reversible: true
name: N-acetylglucosamine 2-epimerase

420224
type: SpeciesReference
stoichiometry: 1.0
species: 308271

420212
type: SpeciesReference
stoichiometry: 1.0
species: 308103

316744
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GA1 (homo sapiens)_C44H79N2O22FULLRCO

321126
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 33_C76H125N5O62S2

318378
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glycophosphatidylinositol (GPI) signal sequence (C-terminal peptide)_Y

974194
type: Reaction
is: ENSRNOG00000014208.4
product: 402357
is: ENSRNOG00000025481.2
reactant: 402272
is: http://identifiers.org/ec-code/2.7.1.30
reversible: false
is: ENSRNOG00000029096.2
is: ENSRNOG00000034116.2
product: 402345
notes: R_GLYKm subsystem: Glycerophospholipid Metabolism R_GLYKm equation: [m] : atp + glyc --> adp + glyc3p + h R_GLYK subsystem: Glycerophospholipid Metabolism R_GLYK equation: [c] : atp + glyc --> adp + glyc3p + h
fast: false
reactant: 402297
product: 402333
product: 402321
is: ENSRNOG00000014431.2
product: 402309
reactant: 402261
reactant: 402284
product: 402369

402357
type: SpeciesReference
stoichiometry: 1.0
species: 318954

402272
type: SpeciesReference
stoichiometry: 1.0
species: 318040

318040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Glycerol_C3H8O3

402345
type: SpeciesReference
stoichiometry: 1.0
species: 317967

402297
type: SpeciesReference
stoichiometry: 1.0
species: 318015

318015
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Glycerol_C3H8O3

402333
type: SpeciesReference
stoichiometry: 1.0
species: 308621

402321
type: SpeciesReference
stoichiometry: 1.0
species: 308645

402309
type: SpeciesReference
stoichiometry: 1.0
species: 317979

317979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Glycerol 3-phosphate_C3H7O6P

402261
type: SpeciesReference
stoichiometry: 1.0
species: 310142

402284
type: SpeciesReference
stoichiometry: 1.0
species: 310166

402369
type: SpeciesReference
stoichiometry: 1.0
species: 319002

975983
type: Reaction
product: 418404
reactant: 418355
notes: R_P4502F1 subsystem: CYP Metabolism R_P4502F1 equation: [c] : h + nadph + npthl + o2 --> h2o + nadp + onpthl R_P4504B1r subsystem: Eicosanoid Metabolism R_P4504B1r equation: [r] : arachd + h + nadph + o2 --> 12harachd + h2o + nadp
reactant: 418307
is: ENSRNOG00000020775.4
reactant: 418331
product: 418428
product: 418416
is: ENSRNOG00000029058.2
is: ENSRNOG00000032004.2
reactant: 418367
reactant: 418343
product: 418379
fast: false
reversible: false
is: http://identifiers.org/ec-code/1.14.14.1
is: ENSRNOG00000033680.2
reactant: 418319
reactant: 418295
product: 418440
product: 418391
reactant: 418283

418404
type: SpeciesReference
stoichiometry: 1.0
species: 304124

304124
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _12 hydroxy arachidonic acid_C20H31O3

418355
type: SpeciesReference
stoichiometry: 1.0
species: 318954

418307
type: SpeciesReference
stoichiometry: 1.0
species: 325235

325235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Naphthalene_C10H8

418331
type: SpeciesReference
stoichiometry: 1.0
species: 319026

418428
type: SpeciesReference
stoichiometry: 1.0
species: 324845

418416
type: SpeciesReference
stoichiometry: 1.0
species: 324797

418367
type: SpeciesReference
stoichiometry: 1.0
species: 324869

418343
type: SpeciesReference
stoichiometry: 1.0
species: 325392

418379
type: SpeciesReference
stoichiometry: 1.0
species: 325877

325877
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: naphthalene epoxide_C10H8O

418319
type: SpeciesReference
stoichiometry: 1.0
species: 309876

309876
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: arachidonic acid_C20H31O2

418295
type: SpeciesReference
stoichiometry: 1.0
species: 324905

418440
type: SpeciesReference
stoichiometry: 1.0
species: 318846

418391
type: SpeciesReference
stoichiometry: 1.0
species: 318918

418283
type: SpeciesReference
stoichiometry: 1.0
species: 325440

320836
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 12_C174H279N12O153S9

311048
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Choline_C5H14NO

973053
type: Reaction
is: ENSRNOG00000018789.4
is: http://identifiers.org/ec-code/3.5.4.4
notes: R_ADAe subsystem: Nucleotides R_ADAe equation: [e] : adn + h + h2o --> ins + nh4 R_ADA subsystem: Purine Catabolism R_ADA equation: [c] : adn + h + h2o --> ins + nh4 R_DADAe subsystem: Nucleotides R_DADAe equation: [e] : dad-2 + h + h2o --> din + nh4 R_DADA subsystem: Nucleotides R_DADA equation: [c] : dad-2 + h + h2o --> din + nh4
product: 389347
product: 389323
reactant: 389213
reversible: false
product: 389311
product: 389359
reactant: 389226
fast: false
reactant: 389201
reactant: 389239
product: 389299
product: 389335
reactant: 389263
reactant: 389251
reactant: 389287
reactant: 389275

389347
type: SpeciesReference
stoichiometry: 1.0
species: 320608

389323
type: SpeciesReference
stoichiometry: 2.0
species: 324991

389213
type: SpeciesReference
stoichiometry: 2.0
species: 318966

389311
type: SpeciesReference
stoichiometry: 2.0
species: 325004

325004
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Ammonium_H4N

389359
type: SpeciesReference
stoichiometry: 1.0
species: 320620

389226
type: SpeciesReference
stoichiometry: 1.0
species: 313050

313050
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Deoxyadenosine_C10H13N5O3

389201
type: SpeciesReference
stoichiometry: 1.0
species: 313038

313038
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deoxyadenosine_C10H13N5O3

389239
type: SpeciesReference
stoichiometry: 2.0
species: 318858

389299
type: SpeciesReference
stoichiometry: 1.0
species: 314211

314211
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deoxyinosine_C10H12N4O4

389335
type: SpeciesReference
stoichiometry: 1.0
species: 314223

314223
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Deoxyinosine_C10H12N4O4

389263
type: SpeciesReference
stoichiometry: 1.0
species: 308573

389251
type: SpeciesReference
stoichiometry: 1.0
species: 308561

389287
type: SpeciesReference
stoichiometry: 2.0
species: 318954

389275
type: SpeciesReference
stoichiometry: 2.0
species: 318846

319941
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 6_C67H98N4O83S9

968108
type: Reaction
is: http://identifiers.org/ec-code/2.5.1.1
is: ENSRNOG00000007915.3
reversible: false
reactant: 343307
reactant: 343319
reactant: 343357
product: 343417
notes: R_MI34PP subsystem: Inositol Phosphate Metabolism R_MI34PP equation: [c] : h2o + mi34p --> mi3p-D + pi R_DMATTx subsystem: Cholesterol Metabolism R_DMATTx equation: [x] : dmpp + ipdp --> grdp + ppi R_GRTTx subsystem: Cholesterol Metabolism R_GRTTx equation: [x] : grdp + ipdp --> frdp + ppi
fast: false
reactant: 343332
product: 343405
is: ENSRNOG00000010062.3
reactant: 343345
is: ENSRNOG00000032349.2
is: http://identifiers.org/ec-code/3.1.3.66
is: http://identifiers.org/ec-code/2.5.1.10
product: 343393
product: 343381
is: ENSRNOG00000037656.1
product: 343369

343307
type: SpeciesReference
stoichiometry: 1.0
species: 318438

318438
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Geranyl diphosphate_C10H17O7P2

343319
type: SpeciesReference
stoichiometry: 1.0
species: 324242

324242
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 3,4-bisphosphate_C6H10O12P2

343357
type: SpeciesReference
stoichiometry: 2.0
species: 320680

343417
type: SpeciesReference
stoichiometry: 1.0
species: 316153

316153
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Farnesyl diphosphate_C15H25O7P2

343332
type: SpeciesReference
stoichiometry: 1.0
species: 314440

314440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Dimethylallyl diphosphate_C5H9O7P2

343405
type: SpeciesReference
stoichiometry: 1.0
species: 324254

343345
type: SpeciesReference
stoichiometry: 1.0
species: 318846

343393
type: SpeciesReference
stoichiometry: 1.0
species: 326891

343381
type: SpeciesReference
stoichiometry: 2.0
species: 327206

343369
type: SpeciesReference
stoichiometry: 1.0
species: 318438

973329
type: Reaction
is: ENSRNOG00000008289.4
reactant: 391905
product: 391929
fast: false
notes: R_PIt2m subsystem: Transport, Mitochondrial R_PIt2m equation: h[c] + pi[c] <==> h[m] + pi[m]
name: phosphate transporter, mitochondrial
reactant: 391893
product: 391917
reversible: true

391905
type: SpeciesReference
stoichiometry: 1.0
species: 318954

391929
type: SpeciesReference
stoichiometry: 1.0
species: 319002

391893
type: SpeciesReference
stoichiometry: 1.0
species: 326891

391917
type: SpeciesReference
stoichiometry: 1.0
species: 326939

970616
type: Reaction
fast: false
reactant: 366178
reversible: true
is: ENSRNOG00000009740.3
reactant: 366202
notes: R_THYOXt subsystem: Transport, Extracellular R_THYOXt equation: hco3[c] + thyox-L[e] <==> hco3[e] + thyox-L[c] R_ESTRONESt subsystem: Transport, Extracellular R_ESTRONESt equation: estrones[e] + hco3[c] <==> estrones[c] + hco3[e] R_TRIODTHYt subsystem: Transport, Extracellular R_TRIODTHYt equation: hco3[c] + triodthy[e] <==> hco3[e] + triodthy[c] R_ESTRADIOLGLCt subsystem: Transport, Extracellular R_ESTRADIOLGLCt equation: estradiolglc[e] + hco3[c] <==> estradiolglc[c] + hco3[e]
product: 366226
product: 366214
reactant: 366154
reactant: 366166
product: 366238
product: 366262
product: 366250
reactant: 366190

366178
type: SpeciesReference
stoichiometry: 1.0
species: 330502

366202
type: SpeciesReference
stoichiometry: 1.0
species: 315552

366226
type: SpeciesReference
stoichiometry: 1.0
species: 315396

366214
type: SpeciesReference
stoichiometry: 1.0
species: 315540

366154
type: SpeciesReference
stoichiometry: 4.0
species: 319110

366166
type: SpeciesReference
stoichiometry: 1.0
species: 330295

366238
type: SpeciesReference
stoichiometry: 1.0
species: 330282

366262
type: SpeciesReference
stoichiometry: 4.0
species: 319122

366250
type: SpeciesReference
stoichiometry: 1.0
species: 330490

366190
type: SpeciesReference
stoichiometry: 1.0
species: 315408

972369
type: Reaction
reactant: 382873
product: 382969
is: http://identifiers.org/ec-code/4.1.1.25
reactant: 382837
reversible: false
product: 382945
reactant: 382813
product: 382993
is: ENSRNOG00000004327.4
product: 382957
reactant: 382885
reactant: 382861
reactant: 382897
product: 382921
reactant: 382849
product: 382933
product: 383005
reactant: 382825
notes: R_5HXKYNDCL subsystem: Tryptophan metabolism R_5HXKYNDCL equation: [c] : 5hxkyn + h --> 5hxkynam + co2 R_HISDC subsystem: Histidine Metabolism R_HISDC equation: [c] : h + his-L --> co2 + hista R_TYRCBOX subsystem: Tyrosine metabolism R_TYRCBOX equation: [c] : h + tyr-L --> co2 + tym R_5HLTDL subsystem: Tryptophan metabolism R_5HLTDL equation: [c] : 5htrp + h --> co2 + srtn R_PHYCBOXL subsystem: Phenylalanine metabolism R_PHYCBOXL equation: [c] : h + phe-L --> co2 + peamn R_LTDCL subsystem: Tryptophan metabolism R_LTDCL equation: [c] : h + trp-L --> co2 + trypta R_3HXKYNDCL subsystem: Tryptophan metabolism R_3HXKYNDCL equation: [c] : h + hLkynr --> 3hxkynam + co2 R_3HLYTCL subsystem: Tyrosine metabolism R_3HLYTCL equation: [c] : 34dhphe + h --> co2 + dopa
is: http://identifiers.org/ec-code/4.1.1.28
product: 382981
is: http://identifiers.org/ec-code/4.1.1.22
reactant: 382909
product: 383017
fast: false

382873
type: SpeciesReference
stoichiometry: 1.0
species: 306439

382969
type: SpeciesReference
stoichiometry: 1.0
species: 329135

382837
type: SpeciesReference
stoichiometry: 1.0
species: 304845

382945
type: SpeciesReference
stoichiometry: 1.0
species: 326590

326590
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phenethylamine_C8H12N

382813
type: SpeciesReference
stoichiometry: 1.0
species: 318942

318942
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Hydroxy-L-kynurenine_C10H12N2O4

382993
type: SpeciesReference
stoichiometry: 1.0
species: 319470

382957
type: SpeciesReference
stoichiometry: 1.0
species: 306475

306475
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Hydroxykynurenamine_C9H13N2O2

382885
type: SpeciesReference
stoichiometry: 1.0
species: 330526

382861
type: SpeciesReference
stoichiometry: 1.0
species: 330766

382897
type: SpeciesReference
stoichiometry: 1.0
species: 326723

382921
type: SpeciesReference
stoichiometry: 1.0
species: 330550

330550
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tryptamine_C10H13N2

382849
type: SpeciesReference
stoichiometry: 1.0
species: 306463

306463
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Hydroxykynurenine_C10H12N2O4

382933
type: SpeciesReference
stoichiometry: 1.0
species: 330742

330742
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tyramine_C8H12NO

383005
type: SpeciesReference
stoichiometry: 8.0
species: 311681

382825
type: SpeciesReference
stoichiometry: 1.0
species: 319446

382981
type: SpeciesReference
stoichiometry: 1.0
species: 305219

305219
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Hydroxykynurenamine_C9H13N2O2

382909
type: SpeciesReference
stoichiometry: 8.0
species: 318954

383017
type: SpeciesReference
stoichiometry: 1.0
species: 314681

966810
type: Reaction
fast: false
notes: R_LPS3 subsystem: Triacylglycerol Synthesis R_LPS3 equation: [c] : h2o + mag_hs --> Rtotal2 + glyc + h
product: 332178
name: lipase
reactant: 332154
reversible: false
reactant: 332166
product: 332202
is: http://identifiers.org/ec-code/3.1.1.23
is: ENSRNOG00000014508.4
product: 332190

332178
type: SpeciesReference
stoichiometry: 1.0
species: 307222

307222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total 2 position_CO2FULLR2

332154
type: SpeciesReference
stoichiometry: 1.0
species: 323539

332166
type: SpeciesReference
stoichiometry: 1.0
species: 318846

332202
type: SpeciesReference
stoichiometry: 1.0
species: 318015

332190
type: SpeciesReference
stoichiometry: 1.0
species: 318954

310348
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Bilirubin monoglucuronide_C39H44N4O12

322410
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Lanosterol_C30H50O

324156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _1D-myo-Inositol 1,4,5,6-tetrakisphosphate_C6H8O18P4

977267
type: Reaction
product: 431936
is: ENSRNOG00000016826.4
is: ENSRNOG00000016838.4
reactant: 431888
is: ENSRNOG00000003164.2
fast: false
is: http://identifiers.org/ec-code/3.1.1.4
name: phospholipase A2
notes: R_PLA2_2e subsystem: Glycerophospholipid Metabolism R_PLA2_2e equation: [e] : h2o + pchol_hs --> Rtotal2 + h + lpchol_hs
is: ENSRNOG00000016798.4
is: ENSRNOG00000017024.4
is: ENSRNOG00000009864.4
product: 431924
product: 431912
reversible: false
reactant: 431900
is: ENSRNOG00000001153.2

431936
type: SpeciesReference
stoichiometry: 1.0
species: 307235

307235
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: R total 2 position_CO2FULLR2

431888
type: SpeciesReference
stoichiometry: 1.0
species: 326409

326409
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2

431924
type: SpeciesReference
stoichiometry: 1.0
species: 318966

431912
type: SpeciesReference
stoichiometry: 1.0
species: 323035

323035
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: lysophosphatidylcholine (homo sapiens)_C8H19NO5PFULLRCO2

431900
type: SpeciesReference
stoichiometry: 1.0
species: 318858

308948
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Etiocholan-3alpha-ol-17-one 3-glucuronide_C25H38O8

971288
type: Reaction
product: 372132
reactant: 372107
is: http://identifiers.org/ec-code/3.1.2.1
reactant: 372120
product: 372157
fast: false
notes: R_ACOAHi subsystem: Pyruvate Metabolism R_ACOAHi equation: [c] : accoa + h2o --> ac + coa + h
is: ENSRNOG00000015081.3
name: acetyl-CoA hydrolase
product: 372144
reversible: false

372132
type: SpeciesReference
stoichiometry: 1.0
species: 311759

372107
type: SpeciesReference
stoichiometry: 1.0
species: 307825

372120
type: SpeciesReference
stoichiometry: 1.0
species: 318846

372157
type: SpeciesReference
stoichiometry: 1.0
species: 318954

372144
type: SpeciesReference
stoichiometry: 1.0
species: 307681

315166
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ebastine_C32H39NO2

323503
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1725H2840N20O620P20

316636
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1900H3128N20O720P20

307367
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: R total_CO2FULLR

975359
type: Reaction
product: 413102
product: 413114
reactant: 413078
reactant: 413066
reactant: 413090
reactant: 413054
is: ENSRNOG00000001762.3
is: ENSRNOG00000012358.4
notes: R_CHLPCTD subsystem: Glycerophospholipid Metabolism R_CHLPCTD equation: [c] : cholp + ctp + h --> cdpchol + ppi R_CPCTDTX subsystem: Glycerophospholipid Metabolism R_CPCTDTX equation: [c] : ctp + h + ntm2amep --> cmpntm2amep + ppi
reversible: false
is: http://identifiers.org/ec-code/2.7.7.15
product: 413126
fast: false

413102
type: SpeciesReference
stoichiometry: 1.0
species: 310927

413114
type: SpeciesReference
stoichiometry: 1.0
species: 311655

311655
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763

413078
type: SpeciesReference
stoichiometry: 2.0
species: 318954

413066
type: SpeciesReference
stoichiometry: 1.0
species: 325368

325368
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Trimethyl-2-aminoethylphosphonate_C5H13NO3P

413090
type: SpeciesReference
stoichiometry: 2.0
species: 312857

413054
type: SpeciesReference
stoichiometry: 1.0
species: 311218

311218
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Choline phosphate_C5H13NO4P

413126
type: SpeciesReference
stoichiometry: 2.0
species: 327157

966870
type: Reaction
notes: R_ATPH2e subsystem: Nucleotides R_ATPH2e equation: [e] : adp + h2o --> amp + h + pi R_ATPH1e subsystem: Nucleotides R_ATPH1e equation: [e] : atp + (2) h2o --> amp + (2) h + (2) pi
fast: false
reactant: 332924
product: 332960
is: ENSRNOG00000013209.2
is: http://identifiers.org/ec-code/3.6.1.5
is: ENSRNOG00000007427.3
product: 332948
product: 332972
is: ENSRNOG00000018982.2
reactant: 332912
is: ENSRNOG00000013102.4
reactant: 332936
reversible: false
is: ENSRNOG00000033206.2

332924
type: SpeciesReference
stoichiometry: 1.0
species: 308633

308633
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: ADP_C10H12N5O10P2

332960
type: SpeciesReference
stoichiometry: 3.0
species: 318966

332948
type: SpeciesReference
stoichiometry: 2.0
species: 309467

309467
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: AMP_C10H12N5O7P

332972
type: SpeciesReference
stoichiometry: 3.0
species: 326903

332912
type: SpeciesReference
stoichiometry: 1.0
species: 310154

310154
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: ATP_C10H12N5O13P3

332936
type: SpeciesReference
stoichiometry: 3.0
species: 318858

969275
type: Reaction
reversible: false
product: 354739
reactant: 354715
notes: R_METLEUex subsystem: Transport, Extracellular R_METLEUex equation: leu-L[c] + met-L[e] --> leu-L[e] + met-L[c]
fast: false
product: 354751
reactant: 354727
name: Methionine/Leucine exchange (Met in)
is: ENSRNOG00000018824.2

354739
type: SpeciesReference
stoichiometry: 1.0
species: 322483

354715
type: SpeciesReference
stoichiometry: 1.0
species: 323999

323999
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Methionine_C5H11NO2S

354751
type: SpeciesReference
stoichiometry: 1.0
species: 323987

354727
type: SpeciesReference
stoichiometry: 1.0
species: 322471

977507
type: Reaction
product: 433978
is: http://identifiers.org/ec-code/3.5.1.6
product: 434015
reactant: 433966
reversible: false
reactant: 433930
notes: R_BUP2 subsystem: Pyrimidine Catabolism R_BUP2 equation: [c] : 3uib + (2) h + h2o --> 3aib-D + co2 + nh4 R_UPPN subsystem: Pyrimidine Catabolism R_UPPN equation: [c] : cala + (2) h + h2o --> ala-B + co2 + nh4
product: 434003
reactant: 433942
product: 433990
reactant: 433954
is: ENSRNOG00000038258.1
fast: false

433978
type: SpeciesReference
stoichiometry: 2.0
species: 324991

434015
type: SpeciesReference
stoichiometry: 1.0
species: 304953

304953
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-3-Amino-isobutanoate_C4H9NO2

433966
type: SpeciesReference
stoichiometry: 4.0
species: 318954

433930
type: SpeciesReference
stoichiometry: 1.0
species: 310721

434003
type: SpeciesReference
stoichiometry: 1.0
species: 309166

433942
type: SpeciesReference
stoichiometry: 1.0
species: 305569

305569
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Ureidoisobutyrate_C5H9N2O3

433990
type: SpeciesReference
stoichiometry: 2.0
species: 311681

433954
type: SpeciesReference
stoichiometry: 2.0
species: 318846

330077
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _5,6,7,8-Tetrahydrofolate_C19H21N7O6

321841
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 2-linked), degradation product 5_C50H82N4O38SX

319098
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: hyaluronan biosynthesis, precursor 1_C14H20NO11

W3 CDTF: Thu Aug 12 17:09:08 BST 2010

306871
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: heptaglutamyl folate (THF)_C49H57N13O24

328917
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Sulfate_O4S

311072
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Choline_C5H14NO

975287
type: Reaction
is: ENSRNOG00000008116.3
notes: R_PPAP subsystem: Triacylglycerol Synthesis R_PPAP equation: [c] : h2o + pa_hs --> dag_hs + pi
is: http://identifiers.org/ec-code/3.1.3.4
is: ENSRNOG00000009980.4
fast: false
reactant: 412351
product: 412363
reactant: 412339
product: 412375
is: ENSRNOG00000000177.2
name: phosphatidic acid phosphatase
reversible: false

412351
type: SpeciesReference
stoichiometry: 1.0
species: 318846

412363
type: SpeciesReference
stoichiometry: 1.0
species: 313110

412339
type: SpeciesReference
stoichiometry: 1.0
species: 325998

412375
type: SpeciesReference
stoichiometry: 1.0
species: 326891

969287
type: Reaction
reversible: false
product: 354839
notes: R_SPRn subsystem: Tetrahydrobiopterin R_SPRn equation: [n] : 6pthp + (2) h + (2) nadph --> (2) nadp + thbpt R_SPR subsystem: Tetrahydrobiopterin R_SPR equation: [c] : 6pthp + (2) h + (2) nadph --> (2) nadp + thbpt
product: 354851
reactant: 354764
reactant: 354777
product: 354875
is: ENSRNOG00000028235.3
is: http://identifiers.org/ec-code/1.1.1.153
reactant: 354815
product: 354863
reactant: 354802
reactant: 354790
reactant: 354827
fast: false
is: ENSRNOG00000015455.4

354839
type: SpeciesReference
stoichiometry: 1.0
species: 329932

329932
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tetrahydrobiopterin_C9H15N5O3

354851
type: SpeciesReference
stoichiometry: 2.0
species: 324833

324833
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Nicotinamide adenine dinucleotide phosphate_C21H25N7O17P3

354764
type: SpeciesReference
stoichiometry: 1.0
species: 306739

306739
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _6-Pyruvoyl-5,6,7,8-tetrahydropterin_C9H11N5O3

354777
type: SpeciesReference
stoichiometry: 2.0
species: 319014

354875
type: SpeciesReference
stoichiometry: 2.0
species: 324797

354815
type: SpeciesReference
stoichiometry: 2.0
species: 318954

354863
type: SpeciesReference
stoichiometry: 1.0
species: 329944

329944
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Tetrahydrobiopterin_C9H15N5O3

354802
type: SpeciesReference
stoichiometry: 1.0
species: 306751

306751
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _6-Pyruvoyl-5,6,7,8-tetrahydropterin_C9H11N5O3

354790
type: SpeciesReference
stoichiometry: 2.0
species: 324893

354827
type: SpeciesReference
stoichiometry: 2.0
species: 324869

309648
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-Pinene-oxide_C10H16O

970288
type: Reaction
is: ENSRNOG00000014044.3
is: ENSRNOG00000018944.3
product: 363128
product: 363153
product: 363141
is: ENSRNOG00000007419.4
reversible: false
name: pantothenate kinase
reactant: 363104
fast: false
notes: R_PNTK subsystem: CoA Biosynthesis R_PNTK equation: [c] : atp + pnto-R --> 4ppan + adp + h
reactant: 363116
is: http://identifiers.org/ec-code/2.7.1.33

363128
type: SpeciesReference
stoichiometry: 1.0
species: 308621

363153
type: SpeciesReference
stoichiometry: 1.0
species: 318954

363141
type: SpeciesReference
stoichiometry: 1.0
species: 306003

363104
type: SpeciesReference
stoichiometry: 1.0
species: 327048

363116
type: SpeciesReference
stoichiometry: 1.0
species: 310142

329980
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate_C27H45O5

325113
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: nifedipine_C17H18N2O6

968337
type: Reaction
is: http://identifiers.org/ec-code/2.3.1.1
notes: R_ACGSm subsystem: Urea cycle/amino group metabolism R_ACGSm equation: [m] : accoa + glu-L --> acglu + coa + h
product: 346410
is: ENSRNOG00000020879.4
fast: false
product: 346386
product: 346398
reactant: 346362
reactant: 346374
name: N-acteylglutamate synthase, mitochondrial
reversible: false

346410
type: SpeciesReference
stoichiometry: 1.0
species: 319002

346386
type: SpeciesReference
stoichiometry: 1.0
species: 308211

346398
type: SpeciesReference
stoichiometry: 1.0
species: 311797

346362
type: SpeciesReference
stoichiometry: 1.0
species: 307849

346374
type: SpeciesReference
stoichiometry: 1.0
species: 317722

317722
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Glutamate_C5H8NO4

971456
type: Reaction
reactant: 373265
reversible: false
reactant: 373253
is: ENSRNOG00000019183.3
notes: R_ALOX15 subsystem: Eicosanoid Metabolism R_ALOX15 equation: [c] : arachd + o2 --> 15HPET
is: http://identifiers.org/ec-code/1.13.11.33
name: Arachidonate 15-lipoxygenase
is: ENSRNOG00000007778.4
fast: false
product: 373277

373265
type: SpeciesReference
stoichiometry: 1.0
species: 325392

373253
type: SpeciesReference
stoichiometry: 1.0
species: 309852

373277
type: SpeciesReference
stoichiometry: 1.0
species: 304220

304220
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _15-Hydroperoxyeicosatetraenoic acid_C20H31O4

316177
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Fructose_C6H12O6

331658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3alpha,7alpha-Dihydroxy-5beta-cholestane_C27H48O2

319542
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847

315829
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Formaldehyde_CH2O

319868
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 24_C31H50NO26

972164
type: Reaction
product: 381306
product: 381282
fast: false
is: ENSRNOG00000013547.3
product: 381294
reactant: 381246
reactant: 381270
reversible: true
reactant: 381258
notes: R_GLYBt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_GLYBt4_LPAREN_2_RPAREN_r equation: glyb[e] + (2) na1[e] <==> glyb[c] + (2) na1[c] R_ABUTt4_LPAREN_2_RPAREN_r subsystem: Transport, Extracellular R_ABUTt4_LPAREN_2_RPAREN_r equation: _4abut[e] + (2) na1[e] <==> 4abut[c] + (2) na1[c]

381306
type: SpeciesReference
stoichiometry: 1.0
species: 317943

381282
type: SpeciesReference
stoichiometry: 1.0
species: 305679

381294
type: SpeciesReference
stoichiometry: 4.0
species: 324616

381246
type: SpeciesReference
stoichiometry: 4.0
species: 324628

381270
type: SpeciesReference
stoichiometry: 1.0
species: 317955

317955
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Glycine betaine_C5H11NO2

381258
type: SpeciesReference
stoichiometry: 1.0
species: 305691

313523
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dodecanoate (n-C12:0)_C12H23O2

972597
type: Reaction
reactant: 385823
is: http://identifiers.org/ec-code/1.1.1.40
name: malic enzyme (NADP)
reversible: false
reactant: 385835
is: ENSRNOG00000021871.3
notes: R_ME2 subsystem: Pyruvate Metabolism R_ME2 equation: [c] : mal-L + nadp --> co2 + nadph + pyr
product: 385859
product: 385871
product: 385847
fast: false

385823
type: SpeciesReference
stoichiometry: 1.0
species: 323588

385835
type: SpeciesReference
stoichiometry: 1.0
species: 324797

385859
type: SpeciesReference
stoichiometry: 1.0
species: 311681

385871
type: SpeciesReference
stoichiometry: 1.0
species: 324869

385847
type: SpeciesReference
stoichiometry: 1.0
species: 328061

328061
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pyruvate_C3H3O3

304461
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _25-Hydroxyvitamin D2_C28H44O2

968084
type: Reaction
notes: R_HGNTOR subsystem: Tyrosine metabolism R_HGNTOR equation: [c] : hgentis + o2 --> 4mlacac + h
reactant: 343187
reversible: false
reactant: 343174
is: ENSRNOG00000002701.4
fast: false
product: 343211
product: 343199
name: Homogentisate:oxygen 1,2-oxidoreductase (decyclizing)
is: http://identifiers.org/ec-code/1.13.11.5

343187
type: SpeciesReference
stoichiometry: 1.0
species: 325392

343174
type: SpeciesReference
stoichiometry: 1.0
species: 319434

319434
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Homogentisate_C8H7O4

343211
type: SpeciesReference
stoichiometry: 1.0
species: 318954

343199
type: SpeciesReference
stoichiometry: 1.0
species: 305889

972080
type: Reaction
product: 380812
reactant: 380800
notes: R_MMEm subsystem: Valine, Leucine, and Isoleucine Metabolism R_MMEm equation: [m] : mmcoa-R <==> mmcoa-S
is: ENSRNOG00000016327.4
is: http://identifiers.org/ec-code/5.1.99.1
fast: false
reversible: true
name: methylmalonyl-CoA epimerase/racemase

380812
type: SpeciesReference
stoichiometry: 1.0
species: 324363

324363
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: (S)-Methylmalonyl-CoA_C25H35N7O19P3S

380800
type: SpeciesReference
stoichiometry: 1.0
species: 324339

324339
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: (R)-Methylmalonyl-CoA_C25H35N7O19P3S

975527
type: Reaction
is: ENSRNOG00000004502.4
product: 414899
reversible: false
is: http://identifiers.org/ec-code/4.3.1.3
product: 414911
name: histidase
fast: false
notes: R_HISD subsystem: Histidine Metabolism R_HISD equation: [c] : his-L --> nh4 + urcan
reactant: 414887

414899
type: SpeciesReference
stoichiometry: 1.0
species: 331223

331223
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Urocanate_C6H5N2O2

414911
type: SpeciesReference
stoichiometry: 1.0
species: 324991

414887
type: SpeciesReference
stoichiometry: 1.0
species: 319446

967218
type: Reaction
is: http://identifiers.org/ec-code/6.2.1.4
product: 335915
product: 335940
reactant: 335854
product: 335928
product: 335878
product: 335890
is: http://identifiers.org/ec-code/6.2.1.5
fast: false
reactant: 335818
reversible: true
reactant: 335805
reactant: 335842
product: 335903
reactant: 335831
is: ENSRNOG00000005587.3
reactant: 335866
notes: R_SUCOASm subsystem: Citric Acid Cycle R_SUCOASm equation: [m] : atp + coa + succ <==> adp + pi + succoa R_SUCOAS1m subsystem: Citric Acid Cycle R_SUCOAS1m equation: [m] : coa + gtp + succ <==> gdp + pi + succoa R_MECOAS1m subsystem: C5-Branched dibasic acid metabolism R_MECOAS1m equation: [m] : coa + gtp + mescon <==> gdp + mescoa + pi R_MECOALm subsystem: C5-Branched dibasic acid metabolism R_MECOALm equation: [m] : atp + coa + mescon <==> adp + mescoa + pi R_ITCOALm subsystem: C5-Branched dibasic acid metabolism R_ITCOALm equation: [m] : atp + coa + itacon <==> adp + itaccoa + pi R_ITCOAL1m subsystem: C5-Branched dibasic acid metabolism R_ITCOAL1m equation: [m] : coa + gtp + itacon <==> gdp + itaccoa + pi

335915
type: SpeciesReference
stoichiometry: 6.0
species: 326939

335940
type: SpeciesReference
stoichiometry: 3.0
species: 317385

335854
type: SpeciesReference
stoichiometry: 2.0
species: 320704

320704
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Itaconate_C5H4O4

335928
type: SpeciesReference
stoichiometry: 3.0
species: 308645

335878
type: SpeciesReference
stoichiometry: 2.0
species: 320692

320692
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Itaconyl-CoA_C26H35N7O19P3S

335890
type: SpeciesReference
stoichiometry: 2.0
species: 329378

335818
type: SpeciesReference
stoichiometry: 6.0
species: 311797

335805
type: SpeciesReference
stoichiometry: 2.0
species: 323975

323975
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Mesaconate_C5H4O4

335842
type: SpeciesReference
stoichiometry: 3.0
species: 318690

335903
type: SpeciesReference
stoichiometry: 2.0
species: 323963

323963
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Mesaconyl-CoA_C26H35N7O19P3S

335831
type: SpeciesReference
stoichiometry: 3.0
species: 310166

335866
type: SpeciesReference
stoichiometry: 2.0
species: 329341

329341
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Succinate_C4H4O4

977495
type: Reaction
name: L-Phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)
is: http://identifiers.org/ec-code/1.14.16.1
fast: false
reversible: false
notes: R_PHETHPTOX2 subsystem: Tyr, Phe, Trp Biosynthesis R_PHETHPTOX2 equation: [c] : o2 + phe-L + thbpt --> thbpt4acam + tyr-L
reactant: 433894
product: 433918
product: 433906
is: ENSRNOG00000004302.4
reactant: 433882
reactant: 433870

433894
type: SpeciesReference
stoichiometry: 1.0
species: 325392

433918
type: SpeciesReference
stoichiometry: 1.0
species: 330766

433906
type: SpeciesReference
stoichiometry: 1.0
species: 329920

329920
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Tetrahydrobiopterin-4a-carbinolamine_C9H15N5O4

433882
type: SpeciesReference
stoichiometry: 1.0
species: 326723

433870
type: SpeciesReference
stoichiometry: 1.0
species: 329932

316660
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C88H147N2O70X

307909
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetone_C3H6O

320210
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hypoxanthine_C5H4N4O

323527
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: mannosyl-3-(phosphoethanolaminyl-mannosyl)-glucosaminyl-acylphosphatidylinositol-Protein (M4A)_C61H116N4O43P4FULLRCO2FULLR2CO2X

973089
type: Reaction
reactant: 389552
notes: R_LCAT1e subsystem: Fatty Acid Metabolism R_LCAT1e equation: [e] : chsterol + pchol_hs --> lpchol_hs + xolest2_hs
name: Lecithin-cholesterol acyltransferase
reversible: false
is: http://identifiers.org/ec-code/2.3.1.43
reactant: 389540
fast: false
product: 389564
is: ENSRNOG00000019573.3
product: 389576

389552
type: SpeciesReference
stoichiometry: 1.0
species: 311267

389540
type: SpeciesReference
stoichiometry: 1.0
species: 326409

389564
type: SpeciesReference
stoichiometry: 1.0
species: 323035

389576
type: SpeciesReference
stoichiometry: 1.0
species: 331779

331779
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: cholesterol ester (from FULLR2)_C27H45FULLR2CO2

312591
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 5_C45H65N2O48S4X

320933
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: keratan sulfate I, degradation product 1_C241H383N17O209S12X

304365
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-1-Pyrroline-3-hydroxy-5-carboxylate_C5H6NO3

311145
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847

314102
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847

313377
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: docosa-4,7,10,13,16-pentaenoyl coenzyme A_C43H64N7O17P3S

329642
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Tetradecanoyl-CoA (n-C14:0CoA)_C35H58N7O17P3S

318546
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GT2 (homo sapiens)_C71H117N5O41FULLRCO

976595
type: Reaction
name: beta-D-Glucosyl-2-coumarinate glucohydrolase
reactant: 423700
product: 423724
fast: false
reversible: false
is: http://identifiers.org/ec-code/3.2.1.21
notes: R_BDG2HCGHD subsystem: Stilbene, coumarine and lignin biosynthesis R_BDG2HCGHD equation: [c] : bdg2hc + h2o --> 2coum + glc-D + h
product: 423712
reactant: 423688
product: 423737
is: ENSRNOG00000024634.3

423700
type: SpeciesReference
stoichiometry: 1.0
species: 310263

310263
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cis-beta-D-Glucosyl-2-hydroxycinnamate_C15H18O8

423724
type: SpeciesReference
stoichiometry: 1.0
species: 317507

423712
type: SpeciesReference
stoichiometry: 1.0
species: 304533

304533
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: cis-2-Hydroxy cinnamate_C9H7O3

423688
type: SpeciesReference
stoichiometry: 1.0
species: 318846

423737
type: SpeciesReference
stoichiometry: 1.0
species: 318954

330586
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: testosterone glucuronide_C25H36O8

975455
type: Reaction
product: 414260
is: http://identifiers.org/ec-code/6.2.1.13
reactant: 414164
product: 414200
reactant: 414152
product: 414248
fast: false
product: 414224
is: ENSRNOG00000018755.4
product: 414212
reactant: 414188
reversible: false
reactant: 414176
is: http://identifiers.org/ec-code/6.2.1.1
product: 414236
notes: R_ACS2 subsystem: Propanoate Metabolism R_ACS2 equation: [c] : atp + coa + ppa --> amp + ppcoa + ppi R_ACCOAL subsystem: Propanoate Metabolism R_ACCOAL equation: [c] : atp + coa + ppa --> adp + pi + ppcoa R_ACS subsystem: Glycolysis/Gluconeogenesis R_ACS equation: [c] : ac + atp + coa --> accoa + amp + ppi

414260
type: SpeciesReference
stoichiometry: 2.0
species: 327157

414164
type: SpeciesReference
stoichiometry: 1.0
species: 307681

414200
type: SpeciesReference
stoichiometry: 1.0
species: 326891

414152
type: SpeciesReference
stoichiometry: 3.0
species: 311759

414248
type: SpeciesReference
stoichiometry: 2.0
species: 309455

414224
type: SpeciesReference
stoichiometry: 2.0
species: 327121

414212
type: SpeciesReference
stoichiometry: 1.0
species: 308621

414188
type: SpeciesReference
stoichiometry: 2.0
species: 327084

414176
type: SpeciesReference
stoichiometry: 3.0
species: 310142

414236
type: SpeciesReference
stoichiometry: 1.0
species: 307825

970927
type: Reaction
reactant: 368562
reactant: 368574
is: ENSRNOG00000009045.4
product: 368635
product: 368611
product: 368623
reactant: 368550
fast: false
product: 368587
notes: R_DOLPGT1_Ler subsystem: N-Glycan Biosynthesis R_DOLPGT1_Ler equation: [r] : (0.1) dolglcp_L + (0.1) m8mpdol_L --> (0.1) dolp_L + (0.1) g1m8mpdol_L + h R_DOLPGT1_Uer subsystem: N-Glycan Biosynthesis R_DOLPGT1_Uer equation: [r] : (0.1) dolglcp_U + (0.1) m8mpdol_U --> (0.1) dolp_U + (0.1) g1m8mpdol_U + h
product: 368599
reactant: 368538
reversible: false

368562
type: SpeciesReference
stoichiometry: 1.0
species: 314572

314572
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dolichyl beta-D-glucosyl phosphate, human uterine homolog_C1085H1780O90P10

368574
type: SpeciesReference
stoichiometry: 1.0
species: 323503

368635
type: SpeciesReference
stoichiometry: 2.0
species: 319026

368611
type: SpeciesReference
stoichiometry: 1.0
species: 316600

316600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1785H2940N20O670P20

368623
type: SpeciesReference
stoichiometry: 1.0
species: 316588

316588
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: alpha-D-Glucosyl-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1840H3028N20O670P20

368550
type: SpeciesReference
stoichiometry: 1.0
species: 314548

314548
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Dolichyl beta-D-glucosyl phosphate, human liver homolog_C1140H1868O90P10

368587
type: SpeciesReference
stoichiometry: 1.0
species: 314645

368599
type: SpeciesReference
stoichiometry: 1.0
species: 314669

368538
type: SpeciesReference
stoichiometry: 1.0
species: 323491

323491
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1780H2928N20O620P20

967146
type: Reaction
product: 335427
notes: R_C3STDH1r subsystem: Cholesterol Metabolism R_C3STDH1r equation: [r] : 4mzym_int1 + nad --> 4mzym_int2 + co2 + h + nadh R_C4STMO2Pr subsystem: Cholesterol Metabolism R_C4STMO2Pr equation: [r] : 4mzym_int2 + nadp + o2 --> co2 + h + nadph + zym_int2 R_C4STMO2r subsystem: Cholesterol Metabolism R_C4STMO2r equation: [r] : 4mzym_int2 + nad + o2 --> co2 + h + nadh + zym_int2 R_C3STDH1Pr subsystem: Cholesterol Metabolism R_C3STDH1Pr equation: [r] : 4mzym_int1 + nadp --> 4mzym_int2 + co2 + h + nadph
reactant: 335364
product: 335388
product: 335414
product: 335453
product: 335440
reactant: 335328
reactant: 335352
reactant: 335340
is: ENSRNOG00000017099.4
reactant: 335376
is: http://identifiers.org/ec-code/5.3.3.1
fast: false
product: 335401
reversible: false

335427
type: SpeciesReference
stoichiometry: 2.0
species: 305967

305967
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _4-Methylzymosterol intermediate 2_C28H44O

335364
type: SpeciesReference
stoichiometry: 2.0
species: 324724

324724
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2

335388
type: SpeciesReference
stoichiometry: 2.0
species: 324905

335414
type: SpeciesReference
stoichiometry: 2.0
species: 332022

332022
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: zymosterol intermediate 2_C27H42O

335453
type: SpeciesReference
stoichiometry: 2.0
species: 324773

324773
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Nicotinamide adenine dinucleotide - reduced_C21H27N7O14P2

335440
type: SpeciesReference
stoichiometry: 4.0
species: 319026

335328
type: SpeciesReference
stoichiometry: 2.0
species: 325440

335352
type: SpeciesReference
stoichiometry: 2.0
species: 324845

335340
type: SpeciesReference
stoichiometry: 2.0
species: 305967

335376
type: SpeciesReference
stoichiometry: 2.0
species: 305955

335401
type: SpeciesReference
stoichiometry: 4.0
species: 311720

311720
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: CO2_CO2

321865
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 2-linked), degradation product 7_C44H73N4O30X

974590
type: Reaction
product: 406531
product: 406555
fast: false
reactant: 406519
reversible: false
reactant: 406506
notes: R_GBGT1 subsystem: Sphingolipid Metabolism R_GBGT1 equation: [g] : gbside_hs + udpacgal --> acgagbside_hs + h + udp
is: ENSRNOG00000032782.2
product: 406543
name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1

406531
type: SpeciesReference
stoichiometry: 1.0
species: 307969

406555
type: SpeciesReference
stoichiometry: 1.0
species: 318978

406519
type: SpeciesReference
stoichiometry: 1.0
species: 330923

330923
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799

406506
type: SpeciesReference
stoichiometry: 1.0
species: 317156

317156
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: globoside (homo sapiens)_C44H79N2O22FULLRCO

406543
type: SpeciesReference
stoichiometry: 1.0
species: 330850

315901
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Fe2+_Fe

973450
type: Reaction
fast: false
is: ENSRNOG00000013585.4
notes: R_NMNATm subsystem: NAD Metabolism R_NMNATm equation: [m] : atp + h + nmn --> nad + ppi R_NNATm subsystem: NAD Metabolism R_NNATm equation: [m] : atp + h + nicrnt --> dnad + ppi R_NNATr subsystem: NAD Metabolism R_NNATr equation: [c] : atp + h + nicrnt <==> dnad + ppi R_NMNATr subsystem: NAD Metabolism R_NMNATr equation: [c] : atp + h + nmn <==> nad + ppi
reactant: 392653
product: 392665
modifier: 392702
modifier: 392775
product: 392689
modifier: 392739
modifier: 392727
reactant: 392629
reactant: 392617
modifier: 392751
product: 392677
is: http://identifiers.org/ec-code/2.7.7.1
is: http://identifiers.org/ec-code/2.7.7.18
reversible: false
modifier: 392715
modifier: 392763
reactant: 392641

392653
type: SpeciesReference
stoichiometry: 1.0
species: 325088

325088
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Nicotinate D-ribonucleotide_C11H12NO9P

392665
type: SpeciesReference
stoichiometry: 1.0
species: 314488

314488
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Deamino-NAD+_C21H24N6O15P2

392689
type: SpeciesReference
stoichiometry: 2.0
species: 327169

325149
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: NMN_C11H14N2O8P

392629
type: SpeciesReference
stoichiometry: 2.0
species: 310166

392617
type: SpeciesReference
stoichiometry: 1.0
species: 325162

325162
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: NMN_C11H14N2O8P

392677
type: SpeciesReference
stoichiometry: 1.0
species: 324700

392641
type: SpeciesReference
stoichiometry: 2.0
species: 319002

969371
type: Reaction
is: ENSRNOG00000025454.3
product: 355514
fast: false
is: ENSRNOG00000023272.3
reactant: 355405
reversible: false
reactant: 355393
product: 355489
reactant: 355417
is: ENSRNOG00000008450.2
product: 355465
is: http://identifiers.org/ec-code/1.17.4.1
reactant: 355429
reactant: 355441
product: 355502
notes: R_RNDR1 subsystem: Nucleotides R_RNDR1 equation: [c] : adp + trdrd --> dadp + h2o + trdox R_RNDR3 subsystem: Nucleotides R_RNDR3 equation: [c] : cdp + trdrd --> dcdp + h2o + trdox R_RNDR2 subsystem: Nucleotides R_RNDR2 equation: [c] : gdp + trdrd --> dgdp + h2o + trdox R_RNDR4 subsystem: Nucleotides R_RNDR4 equation: [c] : trdrd + udp --> dudp + h2o + trdox
product: 355477
product: 355453

355514
type: SpeciesReference
stoichiometry: 1.0
species: 313643

355405
type: SpeciesReference
stoichiometry: 1.0
species: 317349

355393
type: SpeciesReference
stoichiometry: 4.0
species: 330441

355489
type: SpeciesReference
stoichiometry: 1.0
species: 313255

355417
type: SpeciesReference
stoichiometry: 1.0
species: 308621

355465
type: SpeciesReference
stoichiometry: 1.0
species: 314949

355429
type: SpeciesReference
stoichiometry: 1.0
species: 330826

355441
type: SpeciesReference
stoichiometry: 1.0
species: 310890

355502
type: SpeciesReference
stoichiometry: 4.0
species: 318846

355477
type: SpeciesReference
stoichiometry: 4.0
species: 330417

355453
type: SpeciesReference
stoichiometry: 1.0
species: 313074

971228
type: Reaction
product: 371697
reactant: 371575
reactant: 371551
fast: false
product: 371709
product: 371613
product: 371588
product: 371661
reactant: 371527
product: 371637
is: ENSRNOG00000017087.4
product: 371685
reactant: 371455
reversible: false
reactant: 371503
product: 371673
product: 371600
reactant: 371443
notes: R_MM5bg subsystem: N-Glycan Biosynthesis R_MM5bg equation: [g] : h2o + m5masnB1 --> m4masn + man R_MM7Cbg subsystem: N-Glycan Biosynthesis R_MM7Cbg equation: [g] : h2o + m7masnC --> m6masnC + man R_MM6B2g subsystem: N-Glycan Biosynthesis R_MM6B2g equation: [g] : h2o + m6masnB2 --> m5masnB2 + man R_MM6bg subsystem: N-Glycan Biosynthesis R_MM6bg equation: [g] : h2o + m6masnC --> m5masnC + man R_MM8Ag subsystem: N-Glycan Biosynthesis R_MM8Ag equation: [g] : h2o + m8masn --> m7masnA + man R_MM6ag subsystem: N-Glycan Biosynthesis R_MM6ag equation: [g] : h2o + m6masnA --> m5masnC + man R_MM8Cg subsystem: N-Glycan Biosynthesis R_MM8Cg equation: [g] : h2o + m8masn --> m7masnC + man R_MM7Cag subsystem: N-Glycan Biosynthesis R_MM7Cag equation: [g] : h2o + m7masnA --> m6masnC + man R_MM6B1ag subsystem: N-Glycan Biosynthesis R_MM6B1ag equation: [g] : h2o + m6masnB1 --> m5masnB1 + man R_MM7Ag subsystem: N-Glycan Biosynthesis R_MM7Ag equation: [g] : h2o + m7masnA --> m6masnA + man R_MM7B2g subsystem: N-Glycan Biosynthesis R_MM7B2g equation: [g] : h2o + m7masnB --> m6masnB2 + man R_MM6B1bg subsystem: N-Glycan Biosynthesis R_MM6B1bg equation: [g] : h2o + m6masnB2 --> m5masnB1 + man R_MM5ag subsystem: N-Glycan Biosynthesis R_MM5ag equation: [g] : h2o + m5masnC --> m4masn + man R_MM5cg subsystem: N-Glycan Biosynthesis R_MM5cg equation: [g] : h2o + m5masnB2 --> m4masn + man R_MM7B1g subsystem: N-Glycan Biosynthesis R_MM7B1g equation: [g] : h2o + m7masnB --> m6masnB1 + man
reactant: 371539
reactant: 371467
reactant: 371491
reactant: 371563
reactant: 371515
product: 371625
reactant: 371479
product: 371649
is: http://identifiers.org/ec-code/3.2.1.113

371697
type: SpeciesReference
stoichiometry: 2.0
species: 323263

371575
type: SpeciesReference
stoichiometry: 1.0
species: 323323

323323
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (alpha-D-mannosyl)6-beta-D-mannosyl-diacetylchitobiosyl-L-asparagine (protein)_C58H97N2O45X

371551
type: SpeciesReference
stoichiometry: 2.0
species: 323467

371709
type: SpeciesReference
stoichiometry: 1.0
species: 323323

371613
type: SpeciesReference
stoichiometry: 2.0
species: 323287

371588
type: SpeciesReference
stoichiometry: 3.0
species: 323227

371661
type: SpeciesReference
stoichiometry: 1.0
species: 323395

371527
type: SpeciesReference
stoichiometry: 2.0
species: 323395

371637
type: SpeciesReference
stoichiometry: 1.0
species: 323335

371685
type: SpeciesReference
stoichiometry: 15.0
species: 323777

371455
type: SpeciesReference
stoichiometry: 1.0
species: 323275

371503
type: SpeciesReference
stoichiometry: 1.0
species: 323335

371673
type: SpeciesReference
stoichiometry: 1.0
species: 323347

371600
type: SpeciesReference
stoichiometry: 1.0
species: 323275

371443
type: SpeciesReference
stoichiometry: 2.0
species: 323407

371539
type: SpeciesReference
stoichiometry: 2.0
species: 323347

371467
type: SpeciesReference
stoichiometry: 1.0
species: 323287

371491
type: SpeciesReference
stoichiometry: 15.0
species: 318870

371563
type: SpeciesReference
stoichiometry: 1.0
species: 323263

371515
type: SpeciesReference
stoichiometry: 1.0
species: 323359

371625
type: SpeciesReference
stoichiometry: 1.0
species: 323431

371479
type: SpeciesReference
stoichiometry: 1.0
species: 323431

371649
type: SpeciesReference
stoichiometry: 2.0
species: 323359

307052
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Cystine_C6H12N2O4S2

968722
type: Reaction
reactant: 349693
product: 349875
product: 349851
reactant: 349632
notes: R_THRt4 subsystem: Transport, Extracellular R_THRt4 equation: na1[e] + thr-L[e] --> na1[c] + thr-L[c] R_HISt4 subsystem: Transport, Extracellular R_HISt4 equation: his-L[e] + na1[e] --> his-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_PROt4 subsystem: Transport, Extracellular R_PROt4 equation: na1[e] + pro-L[e] --> na1[c] + pro-L[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c]
reactant: 349681
product: 349839
product: 349815
fast: false
product: 349887
reactant: 349730
reactant: 349669
reactant: 349657
product: 349791
product: 349766
reactant: 349742
reactant: 349705
reactant: 349717
product: 349863
reactant: 349754
product: 349803
product: 349779
reactant: 349645
product: 349827
is: ENSRNOG00000006305.4
reversible: false

349693
type: SpeciesReference
stoichiometry: 1.0
species: 327579

349875
type: SpeciesReference
stoichiometry: 1.0
species: 326723

349851
type: SpeciesReference
stoichiometry: 1.0
species: 330186

349632
type: SpeciesReference
stoichiometry: 1.0
species: 319458

349681
type: SpeciesReference
stoichiometry: 10.0
species: 324628

349839
type: SpeciesReference
stoichiometry: 1.0
species: 323987

349815
type: SpeciesReference
stoichiometry: 10.0
species: 324616

349887
type: SpeciesReference
stoichiometry: 1.0
species: 327567

349730
type: SpeciesReference
stoichiometry: 1.0
species: 317630

349669
type: SpeciesReference
stoichiometry: 1.0
species: 323999

349657
type: SpeciesReference
stoichiometry: 1.0
species: 310046

349791
type: SpeciesReference
stoichiometry: 1.0
species: 317617

349766
type: SpeciesReference
stoichiometry: 1.0
species: 317871

349742
type: SpeciesReference
stoichiometry: 1.0
species: 328785

349705
type: SpeciesReference
stoichiometry: 1.0
species: 317883

349717
type: SpeciesReference
stoichiometry: 1.0
species: 330198

349863
type: SpeciesReference
stoichiometry: 1.0
species: 309251

349754
type: SpeciesReference
stoichiometry: 1.0
species: 326735

349803
type: SpeciesReference
stoichiometry: 1.0
species: 319446

349779
type: SpeciesReference
stoichiometry: 1.0
species: 328773

349645
type: SpeciesReference
stoichiometry: 1.0
species: 309263

349827
type: SpeciesReference
stoichiometry: 1.0
species: 310033

320198
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: hydroxylated taxol_C47H31NO15

304425
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _24R,25-Dihydroxyvitamin D3_C27H44O3

970486
type: Reaction
product: 364597
is: ENSRNOG00000004786.3
product: 364561
is: ENSRNOG00000015751.3
product: 364585
notes: R_FAH3 subsystem: CYP Metabolism R_FAH3 equation: [c] : h + hdca + nadph + o2 --> h2o + nadp + whhdca R_FAH1 subsystem: CYP Metabolism R_FAH1 equation: [c] : ddca + h + nadph + o2 --> h2o + nadp + whddca R_FAH2 subsystem: CYP Metabolism R_FAH2 equation: [c] : h + nadph + o2 + ttdca --> h2o + nadp + whttdca
reactant: 364549
reactant: 364525
fast: false
is: ENSRNOG00000034157.2
product: 364573
reactant: 364489
reactant: 364513
is: ENSRNOG00000032895.2
reactant: 364501
reversible: false
product: 364610
reactant: 364537

364597
type: SpeciesReference
stoichiometry: 3.0
species: 324797

364561
type: SpeciesReference
stoichiometry: 1.0
species: 331550

331550
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: omega hydroxy tetradecanoate (n-C14:0)_C14H27O3

364585
type: SpeciesReference
stoichiometry: 1.0
species: 331526

331526
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: omega hydroxy hexadecanoate (n-C16:0)_C16H31O3

364549
type: SpeciesReference
stoichiometry: 3.0
species: 324869

364525
type: SpeciesReference
stoichiometry: 3.0
species: 325392

364573
type: SpeciesReference
stoichiometry: 1.0
species: 331514

364489
type: SpeciesReference
stoichiometry: 1.0
species: 319170

364513
type: SpeciesReference
stoichiometry: 1.0
species: 313523

364501
type: SpeciesReference
stoichiometry: 1.0
species: 330682

330682
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetradecanoate (n-C14:0)_C14H27O2

364610
type: SpeciesReference
stoichiometry: 3.0
species: 318846

364537
type: SpeciesReference
stoichiometry: 3.0
species: 318954

973414
type: Reaction
fast: false
reactant: 392387
reactant: 392363
reversible: true
product: 392423
is: ENSRNOG00000016337.3
reactant: 392375
product: 392399
product: 392411
notes: R_PROSTGF2t subsystem: Transport, Extracellular R_PROSTGF2t equation: prostgf2[e] <==> prostgf2[c] R_SRTNtu subsystem: Transport, Extracellular R_SRTNtu equation: srtn[e] <==> srtn[c] R_PROSTGE2t2 subsystem: Transport, Extracellular R_PROSTGE2t2 equation: prostge2[e] <==> prostge2[c]

392387
type: SpeciesReference
stoichiometry: 1.0
species: 327748

327748
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Prostaglandin F2alpha_C20H33O5

392363
type: SpeciesReference
stoichiometry: 1.0
species: 329148

329148
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Serotonin_C10H13N2O

392423
type: SpeciesReference
stoichiometry: 1.0
species: 329135

392375
type: SpeciesReference
stoichiometry: 1.0
species: 327712

392399
type: SpeciesReference
stoichiometry: 1.0
species: 327700

392411
type: SpeciesReference
stoichiometry: 1.0
species: 327736

308693
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: ADPglucose_C16H23N5O15P2

330210
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Thymine_C5H6N2O2

324712
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Nicotinamide adenine dinucleotide_C21H26N7O14P2

972765
type: Reaction
notes: R_GLNtN1 subsystem: Transport, Extracellular R_GLNtN1 equation: gln-L[e] + h[c] + (2) na1[e] <==> gln-L[c] + h[e] + (2) na1[c] R_ASNtN1 subsystem: Transport, Extracellular R_ASNtN1 equation: asn-L[e] + h[c] + (2) na1[e] <==> asn-L[c] + h[e] + (2) na1[c] R_ALAtN1 subsystem: Transport, Extracellular R_ALAtN1 equation: ala-L[e] + h[c] + (2) na1[e] <==> ala-L[c] + h[e] + (2) na1[c] R_HIStN1 subsystem: Transport, Extracellular R_HIStN1 equation: h[c] + his-L[e] + (2) na1[e] <==> h[e] + his-L[c] + (2) na1[c]
product: 387221
is: ENSRNOG00000016827.4
product: 387257
reactant: 387161
reactant: 387197
product: 387245
reactant: 387173
product: 387269
reactant: 387137
fast: false
reactant: 387149
reactant: 387185
reversible: true
product: 387233
product: 387209

387221
type: SpeciesReference
stoichiometry: 1.0
species: 317617

387257
type: SpeciesReference
stoichiometry: 1.0
species: 310033

387161
type: SpeciesReference
stoichiometry: 1.0
species: 310046

387197
type: SpeciesReference
stoichiometry: 4.0
species: 318954

387245
type: SpeciesReference
stoichiometry: 8.0
species: 324616

387173
type: SpeciesReference
stoichiometry: 8.0
species: 324628

387269
type: SpeciesReference
stoichiometry: 1.0
species: 309251

387137
type: SpeciesReference
stoichiometry: 1.0
species: 319458

387149
type: SpeciesReference
stoichiometry: 1.0
species: 309263

387185
type: SpeciesReference
stoichiometry: 1.0
species: 317630

387233
type: SpeciesReference
stoichiometry: 1.0
species: 319446

387209
type: SpeciesReference
stoichiometry: 4.0
species: 318966

971684
type: Reaction
product: 377585
reactant: 377369
reversible: false
reactant: 377441
reactant: 377309
reactant: 377273
product: 377646
reactant: 377285
reactant: 377417
reactant: 377429
reactant: 377381
product: 377561
is: ENSRNOG00000003918.3
reactant: 377345
product: 377670
reactant: 377393
reactant: 377357
reactant: 377321
product: 377489
reactant: 377333
reactant: 377405
product: 377537
is: ENSRNOG00000016331.2
product: 377634
fast: false
product: 377597
product: 377513
product: 377477
product: 377501
product: 377549
product: 377658
reactant: 377297
notes: R_DNDPt49m subsystem: Transport, Mitochondrial R_DNDPt49m equation: dadp[m] + dttp[c] --> dadp[c] + dttp[m] R_DNDPt22m subsystem: Transport, Mitochondrial R_DNDPt22m equation: dtdp[c] + dudp[m] --> dtdp[m] + dudp[c] R_DNDPt17m subsystem: Transport, Mitochondrial R_DNDPt17m equation: dcdp[m] + dudp[c] --> dcdp[c] + dudp[m] R_DNDPt11m subsystem: Transport, Mitochondrial R_DNDPt11m equation: dadp[c] + dgdp[m] --> dadp[m] + dgdp[c] R_DNDPt52m subsystem: Transport, Mitochondrial R_DNDPt52m equation: dctp[c] + dudp[m] --> dctp[m] + dudp[c] R_DNDPt2m subsystem: Transport, Mitochondrial R_DNDPt2m equation: atp[m] + datp[c] --> atp[c] + datp[m] R_DNDPt63m subsystem: Transport, Mitochondrial R_DNDPt63m equation: dcdp[m] + dgtp[c] --> dcdp[c] + dgtp[m] R_DNDPt47m subsystem: Transport, Mitochondrial R_DNDPt47m equation: dtdp[m] + dttp[c] --> dtdp[c] + dttp[m] R_DNDPt13m subsystem: Transport, Mitochondrial R_DNDPt13m equation: atp[m] + dadp[c] --> atp[c] + dadp[m] R_DNDPt32m subsystem: Transport, Mitochondrial R_DNDPt32m equation: atp[m] + dgdp[c] --> atp[c] + dgdp[m] R_DNDPt12m subsystem: Transport, Mitochondrial R_DNDPt12m equation: adp[m] + dadp[c] --> adp[c] + dadp[m] R_DNDPt46m subsystem: Transport, Mitochondrial R_DNDPt46m equation: dttp[c] + dudp[m] --> dttp[m] + dudp[c] R_DNDPt28m subsystem: Transport, Mitochondrial R_DNDPt28m equation: dcdp[c] + dgdp[m] --> dcdp[m] + dgdp[c] R_DNDPt60m subsystem: Transport, Mitochondrial R_DNDPt60m equation: dgtp[c] + dudp[m] --> dgtp[m] + dudp[c] R_DNDPt24m subsystem: Transport, Mitochondrial R_DNDPt24m equation: dadp[m] + dtdp[c] --> dadp[c] + dtdp[m] R_DNDPt30m subsystem: Transport, Mitochondrial R_DNDPt30m equation: adp[m] + dcdp[c] --> adp[c] + dcdp[m] R_DNDPt54m subsystem: Transport, Mitochondrial R_DNDPt54m equation: dadp[m] + dctp[c] --> dadp[c] + dctp[m] R_DNDPt29m subsystem: Transport, Mitochondrial R_DNDPt29m equation: dadp[m] + dcdp[c] --> dadp[c] + dcdp[m] R_DNDPt8m subsystem: Transport, Mitochondrial R_DNDPt8m equation: da…
reactant: 377453
product: 377573
reactant: 377465
product: 377622
product: 377609
product: 377525

377585
type: SpeciesReference
stoichiometry: 5.0
species: 313655

313655
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dGDP_C10H12N5O10P2

377369
type: SpeciesReference
stoichiometry: 6.0
species: 314802

314802
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dTDP_C10H13N2O11P2

377441
type: SpeciesReference
stoichiometry: 9.0
species: 313086

377309
type: SpeciesReference
stoichiometry: 6.0
species: 313074

377273
type: SpeciesReference
stoichiometry: 9.0
species: 314961

314961
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dUDP_C9H11N2O11P2

377646
type: SpeciesReference
stoichiometry: 9.0
species: 313255

377285
type: SpeciesReference
stoichiometry: 8.0
species: 314814

377417
type: SpeciesReference
stoichiometry: 9.0
species: 313267

313267
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dCDP_C9H12N3O10P2

377429
type: SpeciesReference
stoichiometry: 6.0
species: 313255

377381
type: SpeciesReference
stoichiometry: 9.0
species: 313655

377561
type: SpeciesReference
stoichiometry: 9.0
species: 314949

377345
type: SpeciesReference
stoichiometry: 9.0
species: 308645

377670
type: SpeciesReference
stoichiometry: 9.0
species: 313643

377393
type: SpeciesReference
stoichiometry: 7.0
species: 313764

377357
type: SpeciesReference
stoichiometry: 7.0
species: 313182

377321
type: SpeciesReference
stoichiometry: 6.0
species: 314949

377489
type: SpeciesReference
stoichiometry: 6.0
species: 313425

313425
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dCTP_C9H12N3O13P3

377333
type: SpeciesReference
stoichiometry: 7.0
species: 314912

314912
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dTTP_C10H13N2O14P3

377405
type: SpeciesReference
stoichiometry: 10.0
species: 310166

377537
type: SpeciesReference
stoichiometry: 10.0
species: 310142

377634
type: SpeciesReference
stoichiometry: 6.0
species: 313267

377597
type: SpeciesReference
stoichiometry: 9.0
species: 308621

377513
type: SpeciesReference
stoichiometry: 7.0
species: 314925

314925
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dTTP_C10H13N2O14P3

377477
type: SpeciesReference
stoichiometry: 6.0
species: 314961

377501
type: SpeciesReference
stoichiometry: 6.0
species: 314814

377549
type: SpeciesReference
stoichiometry: 9.0
species: 313074

377658
type: SpeciesReference
stoichiometry: 6.0
species: 313086

377297
type: SpeciesReference
stoichiometry: 7.0
species: 315058

315058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dUTP_C9H11N2O14P3

377453
type: SpeciesReference
stoichiometry: 5.0
species: 313643

377573
type: SpeciesReference
stoichiometry: 8.0
species: 314802

377465
type: SpeciesReference
stoichiometry: 6.0
species: 313413

377622
type: SpeciesReference
stoichiometry: 7.0
species: 315070

315070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dUTP_C9H11N2O14P3

377609
type: SpeciesReference
stoichiometry: 7.0
species: 313776

313776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dGTP_C10H12N5O13P3

377525
type: SpeciesReference
stoichiometry: 7.0
species: 313194

973257
type: Reaction
product: 390979
is: http://identifiers.org/ec-code/1.3.1.21
reactant: 390966
product: 390991
notes: R_DHCR71r subsystem: Cholesterol Metabolism R_DHCR71r equation: [r] : ddsmsterol + h + nadph --> dsmsterol + nadp R_DHCR72r subsystem: Cholesterol Metabolism R_DHCR72r equation: [r] : 7dhchsterol + h + nadph --> chsterol + nadp
is: ENSRNOG00000020776.3
product: 391003
reversible: false
reactant: 390954
reactant: 390930
reactant: 390942
fast: false

390979
type: SpeciesReference
stoichiometry: 1.0
species: 314778

390966
type: SpeciesReference
stoichiometry: 2.0
species: 319026

390991
type: SpeciesReference
stoichiometry: 1.0
species: 311315

391003
type: SpeciesReference
stoichiometry: 2.0
species: 324845

390954
type: SpeciesReference
stoichiometry: 1.0
species: 306811

390930
type: SpeciesReference
stoichiometry: 2.0
species: 324905

390942
type: SpeciesReference
stoichiometry: 1.0
species: 313559

313559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _7-Dehydrodesmosterol_C27H42O

316311
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799

324266
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 4-phosphate_C6H11O9P

328315
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Retinoate_C20H27O2

975755
type: Reaction
reactant: 416608
reactant: 416596
reactant: 416572
notes: R_ADNCYC subsystem: Nucleotides R_ADNCYC equation: [c] : atp --> camp + ppi R_ALOX52 subsystem: Eicosanoid Metabolism R_ALOX52 equation: [c] : 5HPET --> h2o + leuktrA4 R_ALOX5 subsystem: Eicosanoid Metabolism R_ALOX5 equation: [c] : arachd + o2 --> 5HPET
product: 416668
reversible: false
product: 416632
product: 416620
fast: false
is: ENSRNOG00000005297.4
reactant: 416584
is: http://identifiers.org/ec-code/1.13.11.34
product: 416656
is: http://identifiers.org/ec-code/4.6.1.1
product: 416644

416608
type: SpeciesReference
stoichiometry: 1.0
species: 325392

416596
type: SpeciesReference
stoichiometry: 1.0
species: 310142

416572
type: SpeciesReference
stoichiometry: 1.0
species: 306125

306125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate_C20H31O4

416668
type: SpeciesReference
stoichiometry: 1.0
species: 327157

416632
type: SpeciesReference
stoichiometry: 1.0
species: 310733

416620
type: SpeciesReference
stoichiometry: 1.0
species: 306125

416584
type: SpeciesReference
stoichiometry: 1.0
species: 309852

416656
type: SpeciesReference
stoichiometry: 1.0
species: 322507

322507
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Leukotriene A4_C20H29O3

416644
type: SpeciesReference
stoichiometry: 1.0
species: 318846

972609
type: Reaction
reactant: 385883
product: 386124
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 385967
reactant: 385955
product: 386258
reactant: 386076
notes: R_BETALDHx subsystem: Glycine, Serine, and Threonine Metabolism R_BETALDHx equation: [c] : betald + h2o + nad --> glyb + (2) h + nadh R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_ABUTD subsystem: beta-Alanine metabolism R_ABUTD equation: [c] : 4abutn + h2o + nad --> 4abut + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_TMABADH subsystem: Lysine Metabolism R_TMABADH equation: [c] : 4tmeabut + h2o + nad --> 4tmeabutn + (2) h + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh
reversible: false
reactant: 386064
is: http://identifiers.org/ec-code/1.2.1.8
reactant: 385907
reactant: 385991
product: 386148
is: http://identifiers.org/ec-code/1.2.1.47
reactant: 386016
product: 386197
reactant: 385979
reactant: 386004
product: 386173
is: http://identifiers.org/ec-code/1.2.1.4
reactant: 385943
product: 386088
reactant: 385931
reactant: 386052
reactant: 386040
product: 386221
product: 386282
product: 386112
is: ENSRNOG00000004027.3
fast: false
product: 386246
product: 386100
product: 386136
is: http://identifiers.org/ec-code/1.2.1.19
reactant: 385919
reactant: 386028
product: 386234
product: 386270
product: 386209
reactant: 385895
product: 386185
product: 386161
is: http://identifiers.org/ec-code/1.2.1.21

385883
type: SpeciesReference
stoichiometry: 1.0
species: 322386

386124
type: SpeciesReference
stoichiometry: 1.0
species: 320560

385967
type: SpeciesReference
stoichiometry: 1.0
species: 306052

306052
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Trimethylammoniobutanal_C7H16NO

385955
type: SpeciesReference
stoichiometry: 1.0
species: 317180

386258
type: SpeciesReference
stoichiometry: 31.0
species: 318954

386076
type: SpeciesReference
stoichiometry: 1.0
species: 322361

386064
type: SpeciesReference
stoichiometry: 1.0
species: 317482

385907
type: SpeciesReference
stoichiometry: 1.0
species: 305728

385991
type: SpeciesReference
stoichiometry: 1.0
species: 310239

386148
type: SpeciesReference
stoichiometry: 1.0
species: 305653

386016
type: SpeciesReference
stoichiometry: 1.0
species: 306379

386197
type: SpeciesReference
stoichiometry: 1.0
species: 322323

385979
type: SpeciesReference
stoichiometry: 2.0
species: 307777

386004
type: SpeciesReference
stoichiometry: 1.0
species: 310275

310275
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Betaine aldehyde_C5H12NO

386173
type: SpeciesReference
stoichiometry: 1.0
species: 306403

385943
type: SpeciesReference
stoichiometry: 14.0
species: 324676

386088
type: SpeciesReference
stoichiometry: 1.0
species: 320488

385931
type: SpeciesReference
stoichiometry: 1.0
species: 328037

386052
type: SpeciesReference
stoichiometry: 16.0
species: 318846

386040
type: SpeciesReference
stoichiometry: 1.0
species: 320356

386221
type: SpeciesReference
stoichiometry: 1.0
species: 306076

306076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Trimethylammoniobutanoate_C7H15NO2

386282
type: SpeciesReference
stoichiometry: 14.0
species: 324749

386112
type: SpeciesReference
stoichiometry: 1.0
species: 305679

386246
type: SpeciesReference
stoichiometry: 1.0
species: 322287

386100
type: SpeciesReference
stoichiometry: 1.0
species: 318052

386136
type: SpeciesReference
stoichiometry: 2.0
species: 307681

385919
type: SpeciesReference
stoichiometry: 1.0
species: 320512

386028
type: SpeciesReference
stoichiometry: 1.0
species: 324797

386234
type: SpeciesReference
stoichiometry: 1.0
species: 309166

386270
type: SpeciesReference
stoichiometry: 1.0
species: 324869

386209
type: SpeciesReference
stoichiometry: 1.0
species: 326651

385895
type: SpeciesReference
stoichiometry: 1.0
species: 324580

386185
type: SpeciesReference
stoichiometry: 1.0
species: 317943

386161
type: SpeciesReference
stoichiometry: 1.0
species: 317567

313934
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dihydroceramide (homo sapiens)_C18H38NO2FULLRCO

969671
type: Reaction
product: 357627
product: 357603
reactant: 357591
name: guanidinoacetate N-methyltransferase (c)
notes: R_GACMTRc subsystem: Urea cycle/amino group metabolism R_GACMTRc equation: [c] : amet + gudac <==> ahcys + creat + h
fast: false
reactant: 357578
product: 357615
reversible: true
is: ENSRNOG00000024577.3
is: http://identifiers.org/ec-code/2.1.1.2

357627
type: SpeciesReference
stoichiometry: 1.0
species: 318954

357603
type: SpeciesReference
stoichiometry: 1.0
species: 308973

357591
type: SpeciesReference
stoichiometry: 1.0
species: 309395

357578
type: SpeciesReference
stoichiometry: 1.0
species: 318738

318738
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Guanidinoacetate_C3H7N3O2

357615
type: SpeciesReference
stoichiometry: 1.0
species: 311954

311954
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Creatine_C4H9N3O2

319194
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Hexadecanoate (n-C16:0)_C16H31O2

306499
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Methoxyindoleacetate_C11H10NO3

970228
type: Reaction
reactant: 362306
product: 362367
is: http://identifiers.org/ec-code/2.7.1.137
product: 362343
notes: R_PIK3 subsystem: Inositol Phosphate Metabolism R_PIK3 equation: [c] : atp + pail_hs --> adp + h + pail3p_hs R_PI5P3K subsystem: Inositol Phosphate Metabolism R_PI5P3K equation: [c] : atp + pail5p_hs --> adp + h + pail35p_hs
reversible: false
product: 362355
reactant: 362331
reactant: 362318
product: 362379
fast: false
is: ENSRNOG00000017840.3

362306
type: SpeciesReference
stoichiometry: 1.0
species: 326264

326264
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1-Phosphatidyl-1D-myo-inositol 5-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2

362367
type: SpeciesReference
stoichiometry: 1.0
species: 326179

326179
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1-Phosphatidyl-1D-myo-inositol 3-phosphate (Homo sapiens)_C9H15O12P2FULLRCO2FULLR2CO2

362343
type: SpeciesReference
stoichiometry: 1.0
species: 326155

362355
type: SpeciesReference
stoichiometry: 2.0
species: 308621

362331
type: SpeciesReference
stoichiometry: 1.0
species: 326288

362318
type: SpeciesReference
stoichiometry: 2.0
species: 310142

362379
type: SpeciesReference
stoichiometry: 2.0
species: 318954

316274
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: L-Fucose_C6H12O5

968024
type: Reaction
product: 342763
reactant: 342595
fast: false
product: 342847
is: http://identifiers.org/ec-code/1.2.1.4
reactant: 342667
product: 342751
reactant: 342715
reactant: 342619
reactant: 342691
reactant: 342739
is: http://identifiers.org/ec-code/1.2.1.21
product: 342787
reactant: 342583
reactant: 342655
notes: R_IMACTD subsystem: Histidine Metabolism R_IMACTD equation: [c] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD2y subsystem: Glycolysis/Gluconeogenesis R_ALDD2y equation: [c] : acald + h2o + nadp --> ac + (2) h + nadph R_GLACO subsystem: Ascorbate and Aldarate Metabolism R_GLACO equation: [c] : glac + (2) h2o + nad --> glcr + (3) h + nadh R_ALDD20x subsystem: Tryptophan metabolism R_ALDD20x equation: [c] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_ALDD2x subsystem: Glycolysis/Gluconeogenesis R_ALDD2x equation: [c] : acald + h2o + nad --> ac + (2) h + nadh R_PYLALDOX subsystem: Limonene and pinene degradation R_PYLALDOX equation: [c] : h2o + nad + pylald --> (2) h + nadh + peracd R_NABTNO subsystem: Arginine and Proline Metabolism R_NABTNO equation: [c] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_5HOXINDACTOX subsystem: Tryptophan metabolism R_5HOXINDACTOX equation: [c] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_BAMPPALDOX subsystem: beta-Alanine metabolism R_BAMPPALDOX equation: [c] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_LCADi subsystem: Pyruvate Metabolism R_LCADi equation: [c] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDD subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDD equation: [c] : gcald + h2o + nad --> glyclt + (2) h + nadh R_LCADi_D subsystem: Pyruvate Metabolism R_LCADi_D equation: [c] : h2o + lald-D + nad --> (2) h + lac-D + nadh
product: 342907
product: 342775
reactant: 342703
product: 342871
product: 342895
product: 342823
product: 342799
reactant: 342607
reactant: 342679
product: 342811
reactant: 342727
reactant: 342643
is: ENSRNOG00000016042.4
is: ENSRNOG00000011497.3
reversible: false
product: 342835
reactant: 342631
is: http://identifiers.org/ec-code/1.2.1.3
product: 342883
product: 342859

342763
type: SpeciesReference
stoichiometry: 1.0
species: 317567

342595
type: SpeciesReference
stoichiometry: 1.0
species: 324580

342847
type: SpeciesReference
stoichiometry: 1.0
species: 309166

342667
type: SpeciesReference
stoichiometry: 11.0
species: 324676

342751
type: SpeciesReference
stoichiometry: 1.0
species: 320488

342715
type: SpeciesReference
stoichiometry: 1.0
species: 317482

342619
type: SpeciesReference
stoichiometry: 1.0
species: 306379

342691
type: SpeciesReference
stoichiometry: 13.0
species: 318846

342739
type: SpeciesReference
stoichiometry: 1.0
species: 310239

342787
type: SpeciesReference
stoichiometry: 1.0
species: 306403

342583
type: SpeciesReference
stoichiometry: 1.0
species: 322386

342655
type: SpeciesReference
stoichiometry: 1.0
species: 328037

342907
type: SpeciesReference
stoichiometry: 11.0
species: 324749

342775
type: SpeciesReference
stoichiometry: 1.0
species: 318052

342703
type: SpeciesReference
stoichiometry: 2.0
species: 307777

342871
type: SpeciesReference
stoichiometry: 25.0
species: 318954

342895
type: SpeciesReference
stoichiometry: 1.0
species: 324869

342823
type: SpeciesReference
stoichiometry: 2.0
species: 307681

342799
type: SpeciesReference
stoichiometry: 1.0
species: 320560

342607
type: SpeciesReference
stoichiometry: 1.0
species: 320512

342679
type: SpeciesReference
stoichiometry: 1.0
species: 317180

342811
type: SpeciesReference
stoichiometry: 1.0
species: 322323

342727
type: SpeciesReference
stoichiometry: 1.0
species: 322361

342643
type: SpeciesReference
stoichiometry: 1.0
species: 320356

342835
type: SpeciesReference
stoichiometry: 1.0
species: 326651

342631
type: SpeciesReference
stoichiometry: 1.0
species: 324797

342883
type: SpeciesReference
stoichiometry: 1.0
species: 305653

342859
type: SpeciesReference
stoichiometry: 1.0
species: 322287

319494
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hydroxymethylbilane_C40H38N4O17

967375
type: Reaction
reactant: 337195
is: ENSRNOG00000029207.2
notes: R_PCt subsystem: Transport, Extracellular R_PCt equation: atp[c] + h2o[c] + pchol_hs[c] <==> adp[c] + h[c] + pchol_hs[e] + pi[c]
product: 337219
reversible: true
name: phosphatidylcholine transporter
product: 337231
is: ENSRNOG00000022305.3
product: 337255
fast: false
reactant: 337183
product: 337243
reactant: 337207

337195
type: SpeciesReference
stoichiometry: 1.0
species: 318846

337219
type: SpeciesReference
stoichiometry: 1.0
species: 308621

337231
type: SpeciesReference
stoichiometry: 1.0
species: 326891

337255
type: SpeciesReference
stoichiometry: 1.0
species: 318954

337183
type: SpeciesReference
stoichiometry: 1.0
species: 326397

337243
type: SpeciesReference
stoichiometry: 1.0
species: 326409

337207
type: SpeciesReference
stoichiometry: 1.0
species: 310142

969843
type: Reaction
product: 359400
reactant: 359388
notes: R_GLCAE2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GLCAE2g equation: [g] : hs_pre10 --> hs_pre11
is: ENSRNOG00000025372.3
is: http://identifiers.org/ec-code/5.1.3.17
fast: false
reversible: false
name: heparosan-N-sulfate-glucuronate 5-epimerase

359400
type: SpeciesReference
stoichiometry: 1.0
species: 320015

359388
type: SpeciesReference
stoichiometry: 1.0
species: 320003

320003
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: heparan sulfate, precursor 10_C79H121N5O77S4X

315925
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide_C8H13N2O9P

975683
type: Reaction
is: ENSRNOG00000020624.2
product: 416081
fast: false
reactant: 416021
is: http://identifiers.org/ec-code/1.3.99.12
notes: R_PPCOAOm subsystem: Propanoate Metabolism R_PPCOAOm equation: [m] : fad + ppcoa --> fadh2 + prpncoa R_ACOAD10m subsystem: Valine, Leucine, and Isoleucine Metabolism R_ACOAD10m equation: [m] : 2mbcoa + fad --> 2mb2coa + fadh2 R_ACOAD1fm subsystem: Butanoate Metabolism R_ACOAD1fm equation: [m] : btcoa + fad --> b2coa + fadh2
product: 416069
reactant: 416057
reversible: false
product: 416093
reactant: 416033
product: 416105
is: http://identifiers.org/ec-code/1.3.99.3
is: http://identifiers.org/ec-code/1.3.99.2
reactant: 416045

416081
type: SpeciesReference
stoichiometry: 1.0
species: 304665

416021
type: SpeciesReference
stoichiometry: 1.0
species: 304677

304677
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Methylbutanoyl-CoA_C26H40N7O17P3S

416069
type: SpeciesReference
stoichiometry: 3.0
species: 315780

416057
type: SpeciesReference
stoichiometry: 3.0
species: 315732

416093
type: SpeciesReference
stoichiometry: 1.0
species: 327796

416033
type: SpeciesReference
stoichiometry: 1.0
species: 310504

416105
type: SpeciesReference
stoichiometry: 1.0
species: 310215

416045
type: SpeciesReference
stoichiometry: 1.0
species: 327133

972537
type: Reaction
product: 385547
fast: false
reversible: false
reactant: 385486
is: ENSRNOG00000036682.1
reactant: 385499
reactant: 385511
product: 385535
is: http://identifiers.org/ec-code/1.5.1.2
product: 385523
reactant: 385474
notes: R_P5CRxm subsystem: Arginine and Proline Metabolism R_P5CRxm equation: [m] : 1pyr5c + (2) h + nadh --> nad + pro-L R_P5CRm subsystem: Arginine and Proline Metabolism R_P5CRm equation: [m] : 1pyr5c + (2) h + nadph --> nadp + pro-L

385547
type: SpeciesReference
stoichiometry: 1.0
species: 324821

385486
type: SpeciesReference
stoichiometry: 1.0
species: 324881

385499
type: SpeciesReference
stoichiometry: 4.0
species: 319002

385511
type: SpeciesReference
stoichiometry: 1.0
species: 324761

385535
type: SpeciesReference
stoichiometry: 1.0
species: 324700

385523
type: SpeciesReference
stoichiometry: 2.0
species: 327603

327603
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Proline_C5H9NO2

385474
type: SpeciesReference
stoichiometry: 2.0
species: 304389

307076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Kynurenine_C10H12N2O3

969683
type: Reaction
reactant: 357639
is: ENSRNOG00000028389.3
notes: R_DNAMTSEn subsystem: Selenoamino acid metabolism R_DNAMTSEn equation: [n] : dna + seasmet --> dna5mtc + h + seahcys R_DNAMTn subsystem: Methionine Metabolism R_DNAMTn equation: [n] : amet + dna --> ahcys + dna5mtc + h
reactant: 357663
product: 357687
is: ENSRNOG00000026132.3
product: 357699
product: 357675
product: 357711
is: http://identifiers.org/ec-code/2.1.1.37
reversible: false
is: ENSRNOG00000026649.3
is: ENSRNOG00000010625.4
reactant: 357651
fast: false
is: ENSRNOG00000020559.4

357639
type: SpeciesReference
stoichiometry: 2.0
species: 314464

314464
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: DNA_C10H17O8PR2

357663
type: SpeciesReference
stoichiometry: 1.0
species: 328641

328641
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Se-Adenosylselenomethionine_C15H23N6O5Se

357687
type: SpeciesReference
stoichiometry: 2.0
species: 319014

357699
type: SpeciesReference
stoichiometry: 1.0
species: 328616

328616
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Se-Adenosylselenohomocysteine_C14H20N6O5Se

357675
type: SpeciesReference
stoichiometry: 2.0
species: 314452

357711
type: SpeciesReference
stoichiometry: 1.0
species: 308997

308997
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: S-Adenosyl-L-homocysteine_C14H20N6O5S

357651
type: SpeciesReference
stoichiometry: 1.0
species: 309419

309419
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: S-Adenosyl-L-methionine_C15H23N6O5S

971852
type: Reaction
reactant: 379166
reactant: 379141
reactant: 379190
is: ENSRNOG00000013552.3
product: 379238
product: 379250
is: ENSRNOG00000013279.4
product: 379214
reactant: 379154
is: http://identifiers.org/ec-code/1.14.19.1
reactant: 379178
notes: R_DESAT18_3 subsystem: Fatty acid elongation R_DESAT18_3 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + odecoa R_DESAT18_5 subsystem: Fatty acid elongation R_DESAT18_5 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + od2coa R_DESAT16_2 subsystem: Fatty acid elongation R_DESAT16_2 equation: [c] : h + nadh + o2 + pmtcoa --> (2) h2o + hdcoa + nad R_DESAT18_4 subsystem: Fatty acid elongation R_DESAT18_4 equation: [c] : h + nadh + o2 + stcoa --> (2) h2o + nad + vacccoa
product: 379262
is: ENSRNOG00000032554.1
product: 379226
reversible: false
fast: false
product: 379202

379166
type: SpeciesReference
stoichiometry: 4.0
species: 325392

379141
type: SpeciesReference
stoichiometry: 1.0
species: 326987

379190
type: SpeciesReference
stoichiometry: 4.0
species: 324749

379238
type: SpeciesReference
stoichiometry: 1.0
species: 325755

379250
type: SpeciesReference
stoichiometry: 1.0
species: 331393

379214
type: SpeciesReference
stoichiometry: 1.0
species: 319254

379154
type: SpeciesReference
stoichiometry: 3.0
species: 329160

379178
type: SpeciesReference
stoichiometry: 4.0
species: 318954

379262
type: SpeciesReference
stoichiometry: 8.0
species: 318846

379226
type: SpeciesReference
stoichiometry: 4.0
species: 324676

379202
type: SpeciesReference
stoichiometry: 1.0
species: 325779

977063
type: Reaction
product: 430432
is: ENSRNOG00000033497.2
is: http://identifiers.org/ec-code/3.1.3.5
product: 430444
product: 430408
reactant: 430274
reactant: 430359
product: 430456
reactant: 430335
reactant: 430323
reactant: 430287
reactant: 430347
notes: R_NT5C subsystem: NAD Metabolism R_NT5C equation: [c] : h2o + nicrnt --> nicrns + pi R_NTD9 subsystem: Nucleotides R_NTD9 equation: [c] : gmp + h2o --> gsn + pi R_NTD6 subsystem: Nucleotides R_NTD6 equation: [c] : damp + h2o --> dad-2 + pi R_NTD11 subsystem: Purine Catabolism R_NTD11 equation: [c] : h2o + imp --> ins + pi R_NTD10 subsystem: Nucleotides R_NTD10 equation: [c] : h2o + xmp --> pi + xtsn R_NTD8 subsystem: Nucleotides R_NTD8 equation: [c] : dgmp + h2o --> dgsn + pi R_NTD7 subsystem: Nucleotides R_NTD7 equation: [c] : amp + h2o --> adn + pi
product: 430372
is: ENSRNOG00000020179.4
product: 430384
reversible: false
reactant: 430299
product: 430396
product: 430420
reactant: 430311
fast: false

430432
type: SpeciesReference
stoichiometry: 1.0
species: 320608

430444
type: SpeciesReference
stoichiometry: 1.0
species: 313728

313728
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Deoxyguanosine_C10H13N5O4

430408
type: SpeciesReference
stoichiometry: 1.0
species: 318450

430274
type: SpeciesReference
stoichiometry: 1.0
species: 331586

430359
type: SpeciesReference
stoichiometry: 1.0
species: 309455

430456
type: SpeciesReference
stoichiometry: 1.0
species: 325064

430335
type: SpeciesReference
stoichiometry: 1.0
species: 313158

430323
type: SpeciesReference
stoichiometry: 1.0
species: 320536

430287
type: SpeciesReference
stoichiometry: 1.0
species: 313679

313679
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dGMP_C10H12N5O7P

430347
type: SpeciesReference
stoichiometry: 7.0
species: 318846

430372
type: SpeciesReference
stoichiometry: 1.0
species: 313038

430384
type: SpeciesReference
stoichiometry: 1.0
species: 331926

331926
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Xanthosine_C10H12N4O6

430299
type: SpeciesReference
stoichiometry: 1.0
species: 325076

430396
type: SpeciesReference
stoichiometry: 7.0
species: 326891

430420
type: SpeciesReference
stoichiometry: 1.0
species: 308561

430311
type: SpeciesReference
stoichiometry: 1.0
species: 318234

973642
type: Reaction
reactant: 395189
fast: false
product: 395273
reactant: 395165
product: 395261
is: ENSRNOG00000004133.3
product: 395297
product: 395285
reactant: 395249
reactant: 395237
reactant: 395177
reactant: 395213
is: ENSRNOG00000011016.4
product: 395333
reactant: 395201
reactant: 395225
product: 395346
is: ENSRNOG00000000924.3
product: 395321
product: 395309
notes: R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_HOMt4 subsystem: Transport, Extracellular R_HOMt4 equation: hom-L[e] + na1[e] --> hom-L[c] + na1[c] R_ORNtiDF subsystem: Transport, Extracellular R_ORNtiDF equation: orn[e] --> orn[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_ARGtiDF subsystem: Transport, Extracellular R_ARGtiDF equation: arg-L[e] --> arg-L[c] R_LYStiDF subsystem: Transport, Extracellular R_LYStiDF equation: lys-L[e] --> lys-L[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c]
reversible: false

395189
type: SpeciesReference
stoichiometry: 4.0
species: 324628

395273
type: SpeciesReference
stoichiometry: 4.0
species: 324616

395165
type: SpeciesReference
stoichiometry: 1.0
species: 322483

395261
type: SpeciesReference
stoichiometry: 1.0
species: 323083

395297
type: SpeciesReference
stoichiometry: 1.0
species: 325902

395285
type: SpeciesReference
stoichiometry: 1.0
species: 309961

395249
type: SpeciesReference
stoichiometry: 1.0
species: 326735

395237
type: SpeciesReference
stoichiometry: 1.0
species: 319578

319578
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Homoserine_C4H9NO3

395177
type: SpeciesReference
stoichiometry: 1.0
species: 309263

395213
type: SpeciesReference
stoichiometry: 1.0
species: 323095

395333
type: SpeciesReference
stoichiometry: 1.0
species: 309251

395201
type: SpeciesReference
stoichiometry: 1.0
species: 309973

395225
type: SpeciesReference
stoichiometry: 1.0
species: 325914

395346
type: SpeciesReference
stoichiometry: 1.0
species: 326723

395321
type: SpeciesReference
stoichiometry: 1.0
species: 319566

319566
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Homoserine_C4H9NO3

395309
type: SpeciesReference
stoichiometry: 1.0
species: 322471

327350
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glycophosphatidylinositol (GPI)-anchored protein precursor_XY

976139
type: Reaction
reactant: 419849
reversible: true
fast: false
is: ENSRNOG00000003163.4
is: ENSRNOG00000022980.3
is: ENSRNOG00000013331.3
notes: R_SUCD1m subsystem: Citric Acid Cycle R_SUCD1m equation: [m] : fad + succ <==> fadh2 + fum
name: succinate dehydrogenase
reactant: 419861
product: 419885
product: 419873
is: http://identifiers.org/ec-code/1.3.99.1
is: ENSRNOG00000007967.4

419849
type: SpeciesReference
stoichiometry: 1.0
species: 329341

419861
type: SpeciesReference
stoichiometry: 1.0
species: 315732

419885
type: SpeciesReference
stoichiometry: 1.0
species: 316528

419873
type: SpeciesReference
stoichiometry: 1.0
species: 315780

968481
type: Reaction
reactant: 347356
is: ENSRNOG00000038282.1
is: http://identifiers.org/ec-code/3.6.1.17
product: 347368
product: 347380
name: Ap4A hydrolase, asymmetrically
is: ENSRNOG00000013110.3
product: 347392
fast: false
reactant: 347344
notes: R_AP4AH1 subsystem: Nucleotides R_AP4AH1 equation: [c] : ap4a + h2o --> amp + atp + (2) h
reversible: false

347356
type: SpeciesReference
stoichiometry: 1.0
species: 309636

309636
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: P1,P4-Bis(5'-adenosyl) tetraphosphate_C20H24N10O19P4

347368
type: SpeciesReference
stoichiometry: 1.0
species: 310142

347380
type: SpeciesReference
stoichiometry: 1.0
species: 309455

347392
type: SpeciesReference
stoichiometry: 2.0
species: 318954

347344
type: SpeciesReference
stoichiometry: 1.0
species: 318846

316287
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: (Gal)2 (GalNAc)1 (Glc)1 (GlcNAc)1 (LFuc)2 (Cer)1_C64H112N3O35FULLRCO

326602
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phosphoenolpyruvate_C3H2O6P

972993
type: Reaction
is: http://identifiers.org/ec-code/2.7.7.9
product: 388924
notes: R_GALU subsystem: Galactose metabolism R_GALU equation: [c] : g1p + h + utp <==> ppi + udpg
reactant: 388876
reversible: true
name: UTP-glucose-1-phosphate uridylyltransferase
product: 388912
is: ENSRNOG00000008079.4
reactant: 388888
fast: false
reactant: 388900

388924
type: SpeciesReference
stoichiometry: 1.0
species: 327157

388876
type: SpeciesReference
stoichiometry: 1.0
species: 316612

388912
type: SpeciesReference
stoichiometry: 1.0
species: 330959

388888
type: SpeciesReference
stoichiometry: 1.0
species: 318954

388900
type: SpeciesReference
stoichiometry: 1.0
species: 331332

974134
type: Reaction
name: Hydroxybenzoate Decaprenyltransferase
is: ENSRNOG00000002194.3
product: 401885
reversible: false
notes: R_HBZOPT10m subsystem: Ubiquinone Biosynthesis R_HBZOPT10m equation: [m] : 4hbz + decdp --> 3dphb + ppi
reactant: 401861
product: 401873
fast: false
reactant: 401849

401885
type: SpeciesReference
stoichiometry: 1.0
species: 327169

401861
type: SpeciesReference
stoichiometry: 1.0
species: 305788

401873
type: SpeciesReference
stoichiometry: 1.0
species: 305013

305013
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-Decaprenyl-4-hydroxybenzoate_C57H85O3

401849
type: SpeciesReference
stoichiometry: 1.0
species: 313595

313595
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: all trans Decaprenyl diphosphate_C50H81O7P2

327555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: D-Proline_C5H9NO2

304881
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3-(4-Hydroxyphenyl)pyruvate_C9H7O4

314874
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dTMP_C10H13N2O8P

970772
type: Reaction
notes: R_SERHL subsystem: Glycine, Serine, and Threonine Metabolism R_SERHL equation: [c] : ser-L --> 2amac + h2o R_THRD_L subsystem: Glycine, Serine, and Threonine Metabolism R_THRD_L equation: [c] : thr-L --> 2obut + nh4
reversible: false
product: 367640
reactant: 367616
fast: false
reactant: 367604
is: http://identifiers.org/ec-code/4.3.1.19
product: 367664
is: ENSRNOG00000001388.3
product: 367628
product: 367652

367640
type: SpeciesReference
stoichiometry: 1.0
species: 304713

304713
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Oxobutanoate_C4H5O3

367616
type: SpeciesReference
stoichiometry: 1.0
species: 330186

367604
type: SpeciesReference
stoichiometry: 1.0
species: 328773

367664
type: SpeciesReference
stoichiometry: 1.0
species: 318846

367628
type: SpeciesReference
stoichiometry: 1.0
species: 304485

304485
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Aminoacrylate_C3H5NO2

367652
type: SpeciesReference
stoichiometry: 1.0
species: 324991

968349
type: Reaction
product: 346543
product: 346531
reactant: 346446
reactant: 346458
is: http://identifiers.org/ec-code/2.7.7.4
product: 346495
is: ENSRNOG00000011068.4
fast: false
reactant: 346422
notes: R_ADSELK subsystem: Selenoamino acid metabolism R_ADSELK equation: [c] : adsel + atp --> 3padsel + adp + h R_SELADT subsystem: Selenoamino acid metabolism R_SELADT equation: [c] : atp + h + sel --> adsel + ppi R_SADT subsystem: Nucleotides R_SADT equation: [c] : atp + h + so4 --> aps + ppi R_ADSK subsystem: Nucleotides R_ADSK equation: [c] : aps + atp --> adp + h + paps
reactant: 346470
product: 346519
reactant: 346434
product: 346507
is: http://identifiers.org/ec-code/2.7.1.25
reversible: false
is: ENSRNOG00000011311.4
product: 346555
reactant: 346482
product: 346568

346543
type: SpeciesReference
stoichiometry: 2.0
species: 308621

346531
type: SpeciesReference
stoichiometry: 1.0
species: 305460

305460
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763

346446
type: SpeciesReference
stoichiometry: 1.0
species: 328653

328653
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Selenate_O4Se

346458
type: SpeciesReference
stoichiometry: 1.0
species: 308887

308887
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adenylylselenate_C10H12N5O10PSe

346495
type: SpeciesReference
stoichiometry: 1.0
species: 309744

309744
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Adenosine 5'-phosphosulfate_C10H12N5O10PS

346422
type: SpeciesReference
stoichiometry: 1.0
species: 309744

346470
type: SpeciesReference
stoichiometry: 1.0
species: 328893

346519
type: SpeciesReference
stoichiometry: 1.0
species: 308887

346434
type: SpeciesReference
stoichiometry: 4.0
species: 310142

346507
type: SpeciesReference
stoichiometry: 1.0
species: 326373

346555
type: SpeciesReference
stoichiometry: 2.0
species: 318954

346482
type: SpeciesReference
stoichiometry: 2.0
species: 318954

346568
type: SpeciesReference
stoichiometry: 2.0
species: 327157

967700
type: Reaction
reactant: 339996
product: 340032
reversible: false
product: 340020
reactant: 340008
name: Sphingomyelin synthase (homo sapiens)
fast: false
notes: R_SMS subsystem: Sphingolipid Metabolism R_SMS equation: [c] : crm_hs + pchol_hs --> dag_hs + sphmyln_hs
is: ENSRNOG00000012536.3

339996
type: SpeciesReference
stoichiometry: 1.0
species: 311990

340032
type: SpeciesReference
stoichiometry: 1.0
species: 329038

329038
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO

340020
type: SpeciesReference
stoichiometry: 1.0
species: 313110

340008
type: SpeciesReference
stoichiometry: 1.0
species: 326397

969059
type: Reaction
product: 352699
reactant: 352565
product: 352662
reactant: 352589
reactant: 352601
fast: false
reversible: true
is: ENSRNOG00000036693.1
reactant: 352553
product: 352711
reactant: 352577
product: 352650
product: 352638
reactant: 352625
reactant: 352613
product: 352686
notes: R_SUCCt2m subsystem: Transport, Mitochondrial R_SUCCt2m equation: pi[m] + succ[c] <==> pi[c] + succ[m] R_MALSO4tm subsystem: Transport, Mitochondrial R_MALSO4tm equation: mal-L[c] + so4[m] <==> mal-L[m] + so4[c] R_FUMTSULtm subsystem: Transport, Mitochondrial R_FUMTSULtm equation: fum[c] + tsul[m] <==> fum[m] + tsul[c] R_FUMSO3tm subsystem: Transport, Mitochondrial R_FUMSO3tm equation: fum[c] + so3[m] <==> fum[m] + so3[c] R_MALSO3tm subsystem: Transport, Mitochondrial R_MALSO3tm equation: mal-L[c] + so3[m] <==> mal-L[m] + so3[c] R_MALTSULtm subsystem: Transport, Mitochondrial R_MALTSULtm equation: mal-L[c] + tsul[m] <==> mal-L[m] + tsul[c] R_FUMSO4tm subsystem: Transport, Mitochondrial R_FUMSO4tm equation: fum[c] + so4[m] <==> fum[m] + so4[c] R_FUMtm subsystem: Transport, Mitochondrial R_FUMtm equation: fum[c] + pi[m] <==> fum[m] + pi[c] R_MALtm subsystem: Transport, Mitochondrial R_MALtm equation: mal-L[c] + pi[m] <==> mal-L[m] + pi[c]
product: 352674

352699
type: SpeciesReference
stoichiometry: 2.0
species: 328893

352565
type: SpeciesReference
stoichiometry: 1.0
species: 329317

329317
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Succinate_C4H4O4

352662
type: SpeciesReference
stoichiometry: 4.0
species: 323600

352589
type: SpeciesReference
stoichiometry: 3.0
species: 326939

352601
type: SpeciesReference
stoichiometry: 4.0
species: 316516

352553
type: SpeciesReference
stoichiometry: 2.0
species: 328881

352711
type: SpeciesReference
stoichiometry: 2.0
species: 328869

328869
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Sulfite_O3S

352577
type: SpeciesReference
stoichiometry: 2.0
species: 328929

352650
type: SpeciesReference
stoichiometry: 3.0
species: 326891

352638
type: SpeciesReference
stoichiometry: 2.0
species: 330634

352625
type: SpeciesReference
stoichiometry: 2.0
species: 330658

330658
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Thiosulfate_O3S2

352613
type: SpeciesReference
stoichiometry: 4.0
species: 323588

352686
type: SpeciesReference
stoichiometry: 4.0
species: 316528

352674
type: SpeciesReference
stoichiometry: 1.0
species: 329341

315480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Estrone_C18H22O2

316480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Type IH glycolipid_C50H89N2O26FULLRCO

977207
type: Reaction
product: 431646
reactant: 431634
reactant: 431622
reversible: true
fast: false
notes: R_GDPFUCtg subsystem: Transport, Golgi Apparatus R_GDPFUCtg equation: gdpfuc[c] + gmp[g] <==> gdpfuc[g] + gmp[c]
name: GDPFuc Golgi transport via CMP antiport
product: 431658
is: ENSRNOG00000007732.4

431646
type: SpeciesReference
stoichiometry: 1.0
species: 318234

431634
type: SpeciesReference
stoichiometry: 1.0
species: 318258

318258
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GMP_C10H12N5O8P

431622
type: SpeciesReference
stoichiometry: 1.0
species: 317422

431658
type: SpeciesReference
stoichiometry: 1.0
species: 317434

317434
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GDP-L-fucose_C16H23N5O15P2

973570
type: Reaction
product: 394631
reactant: 394619
notes: R_FRUt1r subsystem: Transport, Extracellular R_FRUt1r equation: fru[e] <==> fru[c]
is: ENSRNOG00000003103.3
fast: false
reversible: true
name: D-fructose transport in via uniport

394631
type: SpeciesReference
stoichiometry: 1.0
species: 316165

316165
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Fructose_C6H12O6

394619
type: SpeciesReference
stoichiometry: 1.0
species: 316177

976067
type: Reaction
notes: R_ACCOAC subsystem: Fatty Acid Metabolism R_ACCOAC equation: [c] : accoa + atp + hco3 --> adp + h + malcoa + pi
reactant: 419417
fast: false
reactant: 419441
product: 419477
reactant: 419429
is: http://identifiers.org/ec-code/6.4.1.2
is: ENSRNOG00000034013.2
product: 419489
name: acetyl-CoA carboxylase
product: 419465
product: 419453
reversible: false

419417
type: SpeciesReference
stoichiometry: 1.0
species: 319110

419441
type: SpeciesReference
stoichiometry: 1.0
species: 307825

419477
type: SpeciesReference
stoichiometry: 1.0
species: 308621

419429
type: SpeciesReference
stoichiometry: 1.0
species: 310142

419489
type: SpeciesReference
stoichiometry: 1.0
species: 318954

419465
type: SpeciesReference
stoichiometry: 1.0
species: 323612

419453
type: SpeciesReference
stoichiometry: 1.0
species: 326891

968625
type: Reaction
notes: R_ST8SIA12 subsystem: Sphingolipid Metabolism R_ST8SIA12 equation: [g] : cmpacna + gm3_hs --> cmp + gd3_hs + h R_ST8SIA11 subsystem: Sphingolipid Metabolism R_ST8SIA11 equation: [g] : acngalgbside_hs + cmpacna --> acnacngalgbside_hs + cmp + h
product: 349019
reactant: 349007
product: 349043
is: http://identifiers.org/ec-code/2.4.99.8
fast: false
reversible: false
is: ENSRNOG00000014018.3
product: 349055
reactant: 348995
product: 349031
reactant: 348983

349019
type: SpeciesReference
stoichiometry: 2.0
species: 318978

349007
type: SpeciesReference
stoichiometry: 1.0
species: 318222

318222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: ganglioside GM3 (homo sapiens)_C41H72N2O20FULLRCO

349043
type: SpeciesReference
stoichiometry: 2.0
species: 311582

349055
type: SpeciesReference
stoichiometry: 1.0
species: 317324

317324
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GD3 (homo sapiens)_C52H88N3O28FULLRCO

348995
type: SpeciesReference
stoichiometry: 1.0
species: 308428

349031
type: SpeciesReference
stoichiometry: 1.0
species: 308332

308332
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: disialyl galactosylgloboside (homo sapiens)_C72H121N4O43FULLRCO

348983
type: SpeciesReference
stoichiometry: 2.0
species: 311630

303968
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _10-formyltetrahydrofolate-[Glu](7)_C50H57N13O25

304521
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _2-Carboxy-2,3-dihydro-5,6-dihydroxyindole_C9H8NO4

976991
type: Reaction
product: 429526
reactant: 429440
reactant: 429416
reactant: 429465
fast: false
reactant: 429428
is: ENSRNOG00000018204.4
product: 429501
product: 429477
product: 429513
product: 429489
reactant: 429453
notes: R_ADNt4 subsystem: Transport, Extracellular R_ADNt4 equation: adn[e] + na1[e] --> adn[c] + na1[c] R_URIt4 subsystem: Transport, Extracellular R_URIt4 equation: na1[e] + uri[e] --> na1[c] + uri[c] R_INSt4 subsystem: Transport, Extracellular R_INSt4 equation: ins[e] + na1[e] --> ins[c] + na1[c] R_GSNt4 subsystem: Transport, Extracellular R_GSNt4 equation: gsn[e] + na1[e] --> gsn[c] + na1[c]
is: ENSRNOG00000028668.3
reversible: false

429526
type: SpeciesReference
stoichiometry: 1.0
species: 331272

429440
type: SpeciesReference
stoichiometry: 1.0
species: 308573

429416
type: SpeciesReference
stoichiometry: 4.0
species: 324628

429465
type: SpeciesReference
stoichiometry: 1.0
species: 320620

429428
type: SpeciesReference
stoichiometry: 1.0
species: 331284

429501
type: SpeciesReference
stoichiometry: 1.0
species: 308561

429477
type: SpeciesReference
stoichiometry: 4.0
species: 324616

429513
type: SpeciesReference
stoichiometry: 1.0
species: 320608

429489
type: SpeciesReference
stoichiometry: 1.0
species: 318450

429453
type: SpeciesReference
stoichiometry: 1.0
species: 318462

967760
type: Reaction
product: 340921
name: Ceramide kinase
is: http://identifiers.org/ec-code/2.7.1.138
reactant: 340897
is: ENSRNOG00000017022.4
product: 340945
notes: R_CERK subsystem: Sphingolipid Metabolism R_CERK equation: [c] : atp + crm_hs --> adp + crmp_hs + h
product: 340933
fast: false
reactant: 340909
reversible: false

340921
type: SpeciesReference
stoichiometry: 1.0
species: 308621

340897
type: SpeciesReference
stoichiometry: 1.0
species: 311990

340945
type: SpeciesReference
stoichiometry: 1.0
species: 318954

340933
type: SpeciesReference
stoichiometry: 1.0
species: 312038

312038
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Ceramide 1-phosphate_C18H35NO5PFULLRCO

340909
type: SpeciesReference
stoichiometry: 1.0
species: 310142

974062
type: Reaction
fast: false
modifier: 401196
modifier: 401159
modifier: 401147
modifier: 401051
modifier: 401027
modifier: 401015
modifier: 401172
modifier: 401257
is: ENSRNOG00000020025.2
modifier: 401087
modifier: 401232
modifier: 401123
modifier: 401184
notes: R_ADNt subsystem: Transport, Extracellular R_ADNt equation: adn[e] <==> adn[c] R_INSt subsystem: Transport, Extracellular R_INSt equation: ins[e] <==> ins[c] R_HYXNt subsystem: Transport, Extracellular R_HYXNt equation: hxan[e] <==> hxan[c] R_URIt subsystem: Transport, Extracellular R_URIt equation: uri[e] <==> uri[c] R_GSNt subsystem: Transport, Extracellular R_GSNt equation: gsn[e] <==> gsn[c] R_CSNt subsystem: Transport, Extracellular R_CSNt equation: csn[e] <==> csn[c] R_URAt subsystem: Transport, Extracellular R_URAt equation: ura[e] <==> ura[c] R_ADEt subsystem: Transport, Extracellular R_ADEt equation: ade[e] <==> ade[c] R_GUAt subsystem: Transport, Extracellular R_GUAt equation: gua[e] <==> gua[c] R_THYMt subsystem: Transport, Extracellular R_THYMt equation: thym[e] <==> thym[c] R_THYMDt1 subsystem: Transport, Extracellular R_THYMDt1 equation: thymd[e] --> thymd[c] R_CYTDt subsystem: Transport, Extracellular R_CYTDt equation: cytd[e] <==> cytd[c]
reversible: false
modifier: 401099
modifier: 401135
modifier: 401003
modifier: 401245
product: 400991
modifier: 401220
modifier: 401075
modifier: 401063
modifier: 401039
reactant: 400979
modifier: 401111
modifier: 401208

318726
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Guanine_C5H5N5O

330222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Thymine_C5H6N2O2

312784
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Cytosine_C4H5N3O

320223
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Hypoxanthine_C5H4N4O

318714
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Guanine_C5H5N5O

400991
type: SpeciesReference
stoichiometry: 1.0
species: 330234

308512
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Adenine_C5H5N5

400979
type: SpeciesReference
stoichiometry: 1.0
species: 330246

975851
type: Reaction
fast: false
reversible: false
product: 417249
reactant: 417225
notes: R_PNTEH subsystem: CoA Catabolism R_PNTEH equation: [c] : h2o + ptth --> cysam + pnto-R
is: ENSRNOG00000039865.1
name: Hydrolase Class ( RXN R02973)
product: 417261
is: ENSRNOG00000016219.4
reactant: 417237

417249
type: SpeciesReference
stoichiometry: 1.0
species: 327048

417225
type: SpeciesReference
stoichiometry: 1.0
species: 327965

327965
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Pantetheine_C11H22N2O4S

417261
type: SpeciesReference
stoichiometry: 1.0
species: 312954

417237
type: SpeciesReference
stoichiometry: 1.0
species: 318846

307560
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Tn antigen_C8H14NO5X

967507
type: Reaction
is: ENSRNOG00000031833.2
is: ENSRNOG00000001957.3
product: 338484
notes: R_ESTSULT subsystem: Steroid Metabolism R_ESTSULT equation: [c] : estrone + paps --> estrones + h + pap R_DHEASULT subsystem: Steroid Metabolism R_DHEASULT equation: [c] : dhea + paps --> dheas + h + pap
fast: false
product: 338460
reactant: 338436
is: http://identifiers.org/ec-code/2.8.2.4
reactant: 338448
product: 338496
reactant: 338424
product: 338472
is: ENSRNOG00000001960.4
is: ENSRNOG00000001967.2
reversible: false
is: http://identifiers.org/ec-code/2.8.2.2

338484
type: SpeciesReference
stoichiometry: 1.0
species: 313994

338460
type: SpeciesReference
stoichiometry: 1.0
species: 315540

338436
type: SpeciesReference
stoichiometry: 1.0
species: 315480

338448
type: SpeciesReference
stoichiometry: 2.0
species: 326373

338496
type: SpeciesReference
stoichiometry: 2.0
species: 318954

338424
type: SpeciesReference
stoichiometry: 1.0
species: 313970

338472
type: SpeciesReference
stoichiometry: 2.0
species: 326349

311978
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Creatine_C4H9N3O2

326143
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: phosphatidylinositol-3,4-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2

971624
type: Reaction
is: ENSRNOG00000031898.2
product: 375766
product: 375742
is: ENSRNOG00000039878.1
is: ENSRNOG00000037897.1
product: 375754
notes: R_ST3GAL61g subsystem: Blood Group Biosynthesis R_ST3GAL61g equation: [g] : cmpacna + gal14acglcgalgluside_hs --> acngal14acglcgalgluside_hs + cmp + h R_ST3GAL62g subsystem: Blood Group Biosynthesis R_ST3GAL62g equation: [g] : cmpacna + galacglcgal14acglcgalgluside_hs --> acngalacglcgal14acglcgalgluside_hs + cmp + h
product: 375730
is: ENSRNOG00000013292.3
is: ENSRNOG00000003303.3
is: ENSRNOG00000009861.3
reactant: 375693
is: ENSRNOG00000031474.1
is: ENSRNOG00000005430.3
is: ENSRNOG00000033146.2
reactant: 375718
reactant: 375705
fast: false
is: ENSRNOG00000032482.1
is: ENSRNOG00000025227.3
reversible: false

375766
type: SpeciesReference
stoichiometry: 2.0
species: 311582

375742
type: SpeciesReference
stoichiometry: 2.0
species: 318978

375754
type: SpeciesReference
stoichiometry: 1.0
species: 308404

308404
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: VI3NeuAc-nLc6Cer_C69H118N4O40FULLRCO

375730
type: SpeciesReference
stoichiometry: 1.0
species: 308392

308392
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799

375693
type: SpeciesReference
stoichiometry: 1.0
species: 316792

316792
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799

375718
type: SpeciesReference
stoichiometry: 1.0
species: 316890

316890
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: i-antigen_C58H102N3O32FULLRCO

375705
type: SpeciesReference
stoichiometry: 2.0
species: 311630

314766
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: disialyl-T antigen_C36H56N3O26X

966858
type: Reaction
is: ENSRNOG00000039957.1
notes: R_P4502A6 subsystem: CYP Metabolism R_P4502A6 equation: [c] : coumarin + h + nadph + o2 --> h2o + hcoumarin + nadp
reactant: 332852
reactant: 332828
product: 332888
reactant: 332864
is: ENSRNOG00000033992.2
is: ENSRNOG00000029143.2
is: ENSRNOG00000031392.1
is: ENSRNOG00000040016.1
is: ENSRNOG00000039967.1
is: ENSRNOG00000025329.3
is: ENSRNOG00000032953.2
product: 332876
is: ENSRNOG00000011814.4
reversible: false
is: ENSRNOG00000028891.1
product: 332900
reactant: 332840
name: cytochrome P450 2A6
fast: false

332852
type: SpeciesReference
stoichiometry: 1.0
species: 318954

332828
type: SpeciesReference
stoichiometry: 1.0
species: 311930

332888
type: SpeciesReference
stoichiometry: 1.0
species: 319146

332864
type: SpeciesReference
stoichiometry: 1.0
species: 324869

332876
type: SpeciesReference
stoichiometry: 1.0
species: 318846

332900
type: SpeciesReference
stoichiometry: 1.0
species: 324797

332840
type: SpeciesReference
stoichiometry: 1.0
species: 325392

316963
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Type IB glycolipid_C56H99N2O31FULLRCO

315985
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Ferrocytochrome C_C42H54FeN8O6S2

973810
type: Reaction
name: hydroxymethylbilane synthase
product: 397375
reactant: 397351
is: ENSRNOG00000010390.4
is: http://identifiers.org/ec-code/4.3.1.8
reactant: 397363
product: 397387
notes: R_HMBS subsystem: Heme Biosynthesis R_HMBS equation: [c] : h2o + (4) ppbng --> hmbil + (4) nh4
fast: false
reversible: false

397375
type: SpeciesReference
stoichiometry: 4.0
species: 324991

397351
type: SpeciesReference
stoichiometry: 4.0
species: 327108

327108
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Porphobilinogen_C10H13N2O4

397363
type: SpeciesReference
stoichiometry: 1.0
species: 318846

397387
type: SpeciesReference
stoichiometry: 1.0
species: 319494

976307
type: Reaction
product: 420706
reactant: 420658
name: _5-Oxoproline amidohydrolase (ATP-hydrolysing) (ir)
is: ENSRNOG00000011781.4
product: 420718
product: 420694
fast: false
is: http://identifiers.org/ec-code/3.5.2.9
reversible: false
reactant: 420670
notes: R_OPAHir subsystem: Glutathione Metabolism R_OPAHir equation: [c] : 5oxpro + atp + (2) h2o --> adp + glu-L + h + pi
product: 420730
reactant: 420682

420706
type: SpeciesReference
stoichiometry: 1.0
species: 317683

420658
type: SpeciesReference
stoichiometry: 1.0
species: 310142

420718
type: SpeciesReference
stoichiometry: 1.0
species: 308621

420694
type: SpeciesReference
stoichiometry: 1.0
species: 326891

420670
type: SpeciesReference
stoichiometry: 1.0
species: 306547

420730
type: SpeciesReference
stoichiometry: 1.0
species: 318954

420682
type: SpeciesReference
stoichiometry: 2.0
species: 318846

324942
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetyl-D-glucosaminyldiphosphodolichol, human uterine homolog_C1105H1810N10O120P20

329812
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: tetracosapentaenoyl coenzyme A, n-6_C45H68N7O17P3S

305375
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Methoxytyramine_C9H14NO2

967567
type: Reaction
product: 338870
reactant: 338846
product: 338882
fast: false
product: 338858
is: ENSRNOG00000023842.3
reversible: false
reactant: 338821
product: 338894
reactant: 338808
notes: R_M4BET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BET2er equation: [r] : mem2emgacpail_hs + pe_hs --> dag_hs + m(em)3gacpail_hs R_H6_APOS_ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H6_APOS_ET2er equation: [r] : em3gacpail_hs + pe_hs --> dag_hs + emem2gacpail_hs R_H7ET2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7ET2er equation: [r] : em2emgacpail_hs + pe_hs --> dag_hs + gpi_hs
reactant: 338833

338870
type: SpeciesReference
stoichiometry: 3.0
species: 313146

338846
type: SpeciesReference
stoichiometry: 1.0
species: 315311

338882
type: SpeciesReference
stoichiometry: 1.0
species: 315348

338858
type: SpeciesReference
stoichiometry: 1.0
species: 318354

338821
type: SpeciesReference
stoichiometry: 3.0
species: 326578

338894
type: SpeciesReference
stoichiometry: 1.0
species: 323515

338808
type: SpeciesReference
stoichiometry: 1.0
species: 315336

338833
type: SpeciesReference
stoichiometry: 1.0
species: 323842

974302
type: Reaction
reactant: 403463
fast: false
reactant: 403451
product: 403475
is: ENSRNOG00000017932.2
reactant: 403415
product: 403523
product: 403559
reversible: false
is: http://identifiers.org/ec-code/2.4.99.4
reactant: 403403
reactant: 403391
product: 403547
product: 403511
reactant: 403439
reactant: 403427
product: 403487
notes: R_S23T4g subsystem: Keratan sulfate biosynthesis R_S23T4g equation: [g] : cmpacna + ksii_core4_pre1 --> cmp + h + ksii_core4_pre2 R_ST3GAL21g subsystem: Sphingolipid Metabolism R_ST3GAL21g equation: [g] : cmpacna + ga1_hs --> cmp + gm1b_hs + h R_ST3GAL22g subsystem: Sphingolipid Metabolism R_ST3GAL22g equation: [g] : cmpacna + gm1_hs --> cmp + gd1a_hs + h R_SIAT4Bg subsystem: Sphingolipid Metabolism R_SIAT4Bg equation: [g] : cmpacna + galgbside_hs --> acngalgbside_hs + cmp + h R_S23T2g subsystem: Keratan sulfate biosynthesis R_S23T2g equation: [g] : cmpacna + core2 --> cmp + h + ksii_core2_pre1 R_ST3GAL23g subsystem: Sphingolipid Metabolism R_ST3GAL23g equation: [g] : cmpacna + gd1b_hs --> cmp + gt1b_hs + h
product: 403535
product: 403499

403463
type: SpeciesReference
stoichiometry: 1.0
species: 311857

403451
type: SpeciesReference
stoichiometry: 1.0
species: 317276

317276
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GD1b (homo sapiens)_C66H111N4O38FULLRCO

403475
type: SpeciesReference
stoichiometry: 1.0
species: 317240

317240
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GD1a (homo sapiens)_C66H111N4O38FULLRCO

403415
type: SpeciesReference
stoichiometry: 6.0
species: 311630

403523
type: SpeciesReference
stoichiometry: 1.0
species: 321937

403559
type: SpeciesReference
stoichiometry: 1.0
species: 318522

318522
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GT1b (homo sapiens)_C77H127N5O46FULLRCO

403403
type: SpeciesReference
stoichiometry: 1.0
species: 318161

318161
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: ganglioside GM1 (homo sapiens)_C55H95N3O30FULLRCO

403391
type: SpeciesReference
stoichiometry: 1.0
species: 317011

317011
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: galactosylgloboside (homo sapiens)_C50H89N2O27FULLRCO

403547
type: SpeciesReference
stoichiometry: 6.0
species: 311582

403511
type: SpeciesReference
stoichiometry: 1.0
species: 318185

403439
type: SpeciesReference
stoichiometry: 1.0
species: 316744

403427
type: SpeciesReference
stoichiometry: 1.0
species: 322131

403487
type: SpeciesReference
stoichiometry: 6.0
species: 318978

403535
type: SpeciesReference
stoichiometry: 1.0
species: 322143

403499
type: SpeciesReference
stoichiometry: 1.0
species: 308428

971156
type: Reaction
reactant: 370934
is: ENSRNOG00000007581.4
product: 371007
product: 370983
is: ENSRNOG00000020650.2
reversible: false
is: ENSRNOG00000016147.3
product: 370970
product: 370995
notes: R_GLUVESSEC subsystem: Transport, Extracellular R_GLUVESSEC equation: atp[c] + glu-L[c] + h2o[c] --> adp[c] + glu-L[e] + h[c] + pi[c]
fast: false
name: L-glutamate secretion via secretory vesicle (ATP driven)
reactant: 370958
reactant: 370946

370934
type: SpeciesReference
stoichiometry: 1.0
species: 310142

371007
type: SpeciesReference
stoichiometry: 1.0
species: 318954

370983
type: SpeciesReference
stoichiometry: 1.0
species: 308621

370970
type: SpeciesReference
stoichiometry: 1.0
species: 326891

370995
type: SpeciesReference
stoichiometry: 1.0
species: 317696

370958
type: SpeciesReference
stoichiometry: 1.0
species: 318846

370946
type: SpeciesReference
stoichiometry: 1.0
species: 317683

306787
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: hexaglutamyl folate (THF)_C44H51N12O21

316708
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: sn-Glycero-3-phosphocholine_C8H20NO6P

970499
type: Reaction
product: 364634
reactant: 364622
notes: R_5MTHFt subsystem: Transport, Extracellular R_5MTHFt equation: _5mthf[e] <==> 5mthf[c]
is: ENSRNOG00000019890.3
is: ENSRNOG00000019902.3
fast: false
reversible: true
name: _5-Methyltetrahydrofolate transport via receptor binding and protolysis

364634
type: SpeciesReference
stoichiometry: 1.0
species: 306523

306523
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Methyltetrahydrofolate_C20H24N7O6

364622
type: SpeciesReference
stoichiometry: 1.0
species: 306535

306535
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _5-Methyltetrahydrofolate_C20H24N7O6

976367
type: Reaction
reversible: true
is: ENSRNOG00000020039.2
reactant: 421188
notes: R_GLCt4 subsystem: Transport, Extracellular R_GLCt4 equation: glc-D[e] + na1[e] <==> glc-D[c] + na1[c] R_GLCt2r subsystem: Transport, Extracellular R_GLCt2r equation: glc-D[e] + h[e] <==> glc-D[c] + h[c]
product: 421237
product: 421225
is: ENSRNOG00000002616.4
product: 421212
is: ENSRNOG00000027076.3
reactant: 421200
reactant: 421176
fast: false
is: ENSRNOG00000006786.4
is: ENSRNOG00000001298.4
is: ENSRNOG00000029979.2

421188
type: SpeciesReference
stoichiometry: 1.0
species: 324628

421237
type: SpeciesReference
stoichiometry: 1.0
species: 318954

421225
type: SpeciesReference
stoichiometry: 2.0
species: 317507

421212
type: SpeciesReference
stoichiometry: 1.0
species: 324616

421200
type: SpeciesReference
stoichiometry: 2.0
species: 317519

421176
type: SpeciesReference
stoichiometry: 1.0
species: 318966

328665
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Selenate_O4Se

323071
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Gal-Xyl-L-Ser (protein)_C11H19O9X

975227
type: Reaction
product: 411904
reactant: 411868
is: ENSRNOG00000014511.2
reactant: 411856
fast: false
reactant: 411892
product: 411916
product: 411940
reactant: 411880
reversible: false
product: 411928
notes: R_DOLPGT3_Ler subsystem: N-Glycan Biosynthesis R_DOLPGT3_Ler equation: [r] : (0.1) dolglcp_L + (0.1) g2m8mpdol_L --> (0.1) dolp_L + (0.1) g3m8mpdol_L + h R_DOLPGT3_Uer subsystem: N-Glycan Biosynthesis R_DOLPGT3_Uer equation: [r] : (0.1) dolglcp_U + (0.1) g2m8mpdol_U --> (0.1) dolp_U + (0.1) g3m8mpdol_U + h
product: 411952

411904
type: SpeciesReference
stoichiometry: 1.0
species: 314645

411868
type: SpeciesReference
stoichiometry: 1.0
species: 314548

411856
type: SpeciesReference
stoichiometry: 1.0
species: 316648

316648
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)2-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1845H3040N20O720P20

411892
type: SpeciesReference
stoichiometry: 1.0
species: 316636

411916
type: SpeciesReference
stoichiometry: 1.0
species: 316684

316684
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human uterine homolog_C1905H3140N20O770P20

411940
type: SpeciesReference
stoichiometry: 1.0
species: 316672

316672
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1960H3228N20O770P20

411880
type: SpeciesReference
stoichiometry: 1.0
species: 314572

411928
type: SpeciesReference
stoichiometry: 1.0
species: 314669

411952
type: SpeciesReference
stoichiometry: 2.0
species: 319026

969227
type: Reaction
is: http://identifiers.org/ec-code/2.6.1.7
reactant: 354461
fast: false
product: 354473
product: 354497
reversible: false
reactant: 354437
notes: R_3HKYNAKGAT subsystem: Tryptophan metabolism R_3HKYNAKGAT equation: [c] : akg + hLkynr --> 42A3HP24DB + glu-L R_KYNAKGAT subsystem: Tryptophan metabolism R_KYNAKGAT equation: [c] : Lkynr + akg --> 4aphdob + glu-L
product: 354485
reactant: 354449
is: ENSRNOG00000016097.4

354461
type: SpeciesReference
stoichiometry: 1.0
species: 307076

354473
type: SpeciesReference
stoichiometry: 1.0
species: 305740

305740
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-(2-Aminophenyl)-2,4-dioxobutanoate_C10H8NO4

354497
type: SpeciesReference
stoichiometry: 1.0
species: 305581

305581
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate_C10H8NO5

354437
type: SpeciesReference
stoichiometry: 2.0
species: 309106

354485
type: SpeciesReference
stoichiometry: 2.0
species: 317683

354449
type: SpeciesReference
stoichiometry: 1.0
species: 318942

311694
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: CO2_CO2

317761
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: gamma-L-Glutamyl-L-cysteine_C8H13N2O5S

314937
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: dTTP_C10H13N2O14P3

310637
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: cervonyl coenzyme A_C43H62N7O17P3S

969143
type: Reaction
modifier: 353735
modifier: 353723
modifier: 353687
fast: false
reactant: 353626
reversible: false
reactant: 353639
reactant: 353614
is: http://identifiers.org/ec-code/6.2.1.3
modifier: 353747
modifier: 353771
product: 353651
modifier: 353711
notes: R_FACOAL150 subsystem: Fatty acid activation R_FACOAL150 equation: [c] : atp + coa + ptdca <==> amp + ppi + ptdcacoa R_FACOAL204i subsystem: Fatty acid activation R_FACOAL204i equation: [c] : arachd + atp + coa --> amp + arachdcoa + ppi R_FACOAL170 subsystem: Fatty acid activation R_FACOAL170 equation: [c] : atp + coa + hpdca <==> amp + hpdcacoa + ppi
product: 353663
is: ENSRNOG00000019180.4
modifier: 353699
modifier: 353759
product: 353675

353626
type: SpeciesReference
stoichiometry: 1.0
species: 309852

353639
type: SpeciesReference
stoichiometry: 1.0
species: 310142

353614
type: SpeciesReference
stoichiometry: 1.0
species: 311759

353651
type: SpeciesReference
stoichiometry: 1.0
species: 309888

353663
type: SpeciesReference
stoichiometry: 1.0
species: 309455

319602
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: heptadecanoate_C17H33O2

353675
type: SpeciesReference
stoichiometry: 1.0
species: 327157

331682
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al_C27H46O3

315202
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ecgonine methyl ester_C10H17NO3

307524
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (S)-Squalene-2,3-epoxide_C30H50O

309588
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: androsterone glucuronide_C25H38O8

326107
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylinositol-3,4,5-trisphosphate (Homo sapiens)_C9H13O18P4FULLRCO2FULLR2CO2

318076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Glycolate_C2H3O3

969963
type: Reaction
product: 360304
reversible: false
reactant: 360207
is: http://identifiers.org/ec-code/5.1.99.4
reactant: 360195
reactant: 360231
reactant: 360219
product: 360291
notes: R_AMACRr subsystem: Bile Acid Biosynthesis R_AMACRr equation: [r] : cholcoar --> cholcoas R_AMACRp subsystem: Bile Acid Biosynthesis R_AMACRp equation: [x] : cholcoar --> cholcoas R_AMACR2p subsystem: Bile Acid Biosynthesis R_AMACR2p equation: [x] : dhcholestancoa + (0.5) o2 --> dhcholoylcoa + h2o R_AMACR2r subsystem: Bile Acid Biosynthesis R_AMACR2r equation: [r] : dhcholestancoa + (0.5) o2 --> dhcholoylcoa + h2o
product: 360316
product: 360279
product: 360267
reactant: 360243
product: 360328
is: ENSRNOG00000018662.4
reactant: 360255
fast: false

360304
type: SpeciesReference
stoichiometry: 1.0
species: 318918

360207
type: SpeciesReference
stoichiometry: 1.0
species: 325440

360195
type: SpeciesReference
stoichiometry: 1.0
species: 311182

360231
type: SpeciesReference
stoichiometry: 1.0
species: 313886

360219
type: SpeciesReference
stoichiometry: 1.0
species: 325452

360291
type: SpeciesReference
stoichiometry: 1.0
species: 313922

360316
type: SpeciesReference
stoichiometry: 1.0
species: 311206

311206
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847

360279
type: SpeciesReference
stoichiometry: 1.0
species: 313910

313910
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775

360267
type: SpeciesReference
stoichiometry: 1.0
species: 318930

318930
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: H2O_H2O

360243
type: SpeciesReference
stoichiometry: 1.0
species: 313898

360328
type: SpeciesReference
stoichiometry: 1.0
species: 311194

311194
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775

360255
type: SpeciesReference
stoichiometry: 1.0
species: 311170

967459
type: Reaction
reactant: 337942
reactant: 337966
product: 337978
notes: R_PI345P5P subsystem: Inositol Phosphate Metabolism R_PI345P5P equation: [c] : h2o + pail345p_hs --> pail34p_hs + pi R_MI145PP subsystem: Inositol Phosphate Metabolism R_MI145PP equation: [c] : h2o + mi145p --> mi14p + pi R_MI1345PP subsystem: Inositol Phosphate Metabolism R_MI1345PP equation: [c] : h2o + mi1345p --> mi134p + pi
is: ENSRNOG00000019361.3
is: ENSRNOG00000019730.3
reactant: 337954
reactant: 337930
product: 338014
product: 338002
reversible: false
product: 337990
is: ENSRNOG00000017635.4
is: http://identifiers.org/ec-code/3.1.3.56
is: ENSRNOG00000017020.4
fast: false

337942
type: SpeciesReference
stoichiometry: 1.0
species: 324168

337966
type: SpeciesReference
stoichiometry: 1.0
species: 324108

337978
type: SpeciesReference
stoichiometry: 1.0
species: 326131

326131
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylinositol-3,4-bisphosphate (Homo sapiens)_C9H14O15P3FULLRCO2FULLR2CO2

337954
type: SpeciesReference
stoichiometry: 3.0
species: 318846

337930
type: SpeciesReference
stoichiometry: 1.0
species: 326107

338014
type: SpeciesReference
stoichiometry: 1.0
species: 324192

338002
type: SpeciesReference
stoichiometry: 3.0
species: 326891

337990
type: SpeciesReference
stoichiometry: 1.0
species: 324144

306559
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: (R)-5-Phosphomevalonate_C6H10O7P

976295
type: Reaction
is: ENSRNOG00000011902.3
reactant: 420586
is: ENSRNOG00000027919.3
product: 420646
product: 420634
product: 420622
is: ENSRNOG00000040151.1
product: 420610
reactant: 420574
reactant: 420562
product: 420598
reversible: true
notes: R_RDH2a subsystem: Vitamin A Metabolism R_RDH2a equation: [c] : nadp + retinol-9-cis <==> h + nadph + retinal-cis-9 R_RDH3a subsystem: Vitamin A Metabolism R_RDH3a equation: [c] : nadp + retinol-cis-11 <==> h + nadph + retinal-11-cis R_RDH1a subsystem: Vitamin A Metabolism R_RDH1a equation: [c] : nadp + retinol <==> h + nadph + retinal
is: ENSRNOG00000011930.3
is: http://identifiers.org/ec-code/1.1.1.105
is: ENSRNOG00000008871.4
reactant: 420550
fast: false

420586
type: SpeciesReference
stoichiometry: 3.0
species: 324797

420646
type: SpeciesReference
stoichiometry: 3.0
species: 324869

420634
type: SpeciesReference
stoichiometry: 1.0
species: 328217

420622
type: SpeciesReference
stoichiometry: 3.0
species: 318954

420610
type: SpeciesReference
stoichiometry: 1.0
species: 328254

420574
type: SpeciesReference
stoichiometry: 1.0
species: 328279

420562
type: SpeciesReference
stoichiometry: 1.0
species: 328303

420598
type: SpeciesReference
stoichiometry: 1.0
species: 328241

420550
type: SpeciesReference
stoichiometry: 1.0
species: 328267

304040
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _10-Formyltetrahydrofolate_C20H21N7O7

969155
type: Reaction
reversible: false
modifier: 353894
reactant: 353795
modifier: 353906
modifier: 353882
fast: false
product: 353870
product: 353845
reactant: 353819
is: ENSRNOG00000008432.4
is: ENSRNOG00000033865.2
modifier: 353919
reactant: 353807
reactant: 353783
product: 353858
notes: R_CHOLtu subsystem: Transport, Extracellular R_CHOLtu equation: chol[e] <==> chol[c] R_CRNtuNa subsystem: Transport, Extracellular R_CRNtuNa equation: crn[e] + na1[e] --> crn[c] + na1[c] R_LYSt4 subsystem: Transport, Extracellular R_LYSt4 equation: lys-L[e] + na1[e] --> lys-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_CRNt subsystem: Transport, Extracellular R_CRNt equation: crn[e] <==> crn[c]
product: 353832

312062
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Carnitine_C7H15NO3

353795
type: SpeciesReference
stoichiometry: 1.0
species: 323999

353870
type: SpeciesReference
stoichiometry: 1.0
species: 323987

353845
type: SpeciesReference
stoichiometry: 3.0
species: 324616

353819
type: SpeciesReference
stoichiometry: 1.0
species: 323095

353807
type: SpeciesReference
stoichiometry: 3.0
species: 324628

353783
type: SpeciesReference
stoichiometry: 1.0
species: 312062

353858
type: SpeciesReference
stoichiometry: 1.0
species: 312050

353832
type: SpeciesReference
stoichiometry: 1.0
species: 323083

318390
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: GQ1b (homo sapiens)_C88H143N6O54FULLRCO

317669
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Glutamate 5-semialdehyde_C5H9NO3

972933
type: Reaction
reactant: 388403
reactant: 388427
reactant: 388391
product: 388439
product: 388464
reactant: 388415
is: ENSRNOG00000032546.2
product: 388477
is: ENSRNOG00000030193.2
is: ENSRNOG00000007997.3
is: ENSRNOG00000026213.3
is: http://identifiers.org/ec-code/2.1.1.43
product: 388451
is: ENSRNOG00000013045.4
reversible: false
is: ENSRNOG00000001062.4
notes: R_LYSMTF3n subsystem: Lysine Metabolism R_LYSMTF3n equation: [n] : Ndmelys + amet --> Ntmelys + ahcys R_LYSMTF1n subsystem: Lysine Metabolism R_LYSMTF1n equation: [n] : amet + peplys --> Nmelys + ahcys R_LYSMTF2n subsystem: Lysine Metabolism R_LYSMTF2n equation: [n] : Nmelys + amet --> Ndmelys + ahcys
is: ENSRNOG00000021206.3
is: ENSRNOG00000039576.1
fast: false
is: ENSRNOG00000015585.3
is: ENSRNOG00000033891.2
is: ENSRNOG00000021680.3

388403
type: SpeciesReference
stoichiometry: 1.0
species: 326627

326627
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Peptidyl-L-lysine_XH

388427
type: SpeciesReference
stoichiometry: 3.0
species: 309419

388391
type: SpeciesReference
stoichiometry: 1.0
species: 307125

307125
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Protein N6,N6-dimethyl-L-lysine_C2H7X

388439
type: SpeciesReference
stoichiometry: 1.0
species: 307125

388464
type: SpeciesReference
stoichiometry: 1.0
species: 307150

307150
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Protein N6,N6,N6-trimethyl-L-lysine_C3H10X

388415
type: SpeciesReference
stoichiometry: 1.0
species: 307137

388477
type: SpeciesReference
stoichiometry: 3.0
species: 308997

388451
type: SpeciesReference
stoichiometry: 1.0
species: 307137

971324
type: Reaction
notes: R_PPM subsystem: Pentose Phosphate Pathway R_PPM equation: [c] : r1p <==> r5p R_PGMT subsystem: Glycolysis/Gluconeogenesis R_PGMT equation: [c] : g1p <==> g6p
reversible: true
fast: false
is: http://identifiers.org/ec-code/5.4.2.7
product: 372277
reactant: 372265
is: ENSRNOG00000009889.4
is: ENSRNOG00000015406.4
product: 372289
reactant: 372253
is: http://identifiers.org/ec-code/5.4.2.2

372277
type: SpeciesReference
stoichiometry: 1.0
species: 328181

372265
type: SpeciesReference
stoichiometry: 1.0
species: 316612

372289
type: SpeciesReference
stoichiometry: 1.0
species: 316720

372253
type: SpeciesReference
stoichiometry: 1.0
species: 328169

311809
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Coenzyme A_C21H32N7O16P3S

331574
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Xanthine_C5H4N4O2

972032
type: Reaction
reversible: true
is: ENSRNOG00000029218.2
product: 380520
is: ENSRNOG00000033730.2
is: http://identifiers.org/ec-code/5.4.99.2
notes: R_MMMm subsystem: Valine, Leucine, and Isoleucine Metabolism R_MMMm equation: [m] : mmcoa-R <==> succoa
reactant: 380508
name: methylmalonyl-CoA mutase
fast: false

380520
type: SpeciesReference
stoichiometry: 1.0
species: 329378

380508
type: SpeciesReference
stoichiometry: 1.0
species: 324339

976535
type: Reaction
is: ENSRNOG00000037605.1
product: 423508
reversible: false
is: ENSRNOG00000012205.2
product: 423484
reactant: 423460
reactant: 423447
fast: false
reactant: 423435
notes: R_GLNS subsystem: Glutamate metabolism R_GLNS equation: [c] : atp + glu-L + nh4 --> adp + gln-L + h + pi
product: 423496
name: glutamine synthetase
product: 423472
is: http://identifiers.org/ec-code/6.3.1.2

423508
type: SpeciesReference
stoichiometry: 1.0
species: 318954

423484
type: SpeciesReference
stoichiometry: 1.0
species: 317617

423460
type: SpeciesReference
stoichiometry: 1.0
species: 317683

423447
type: SpeciesReference
stoichiometry: 1.0
species: 324991

423435
type: SpeciesReference
stoichiometry: 1.0
species: 310142

423496
type: SpeciesReference
stoichiometry: 1.0
species: 308621

423472
type: SpeciesReference
stoichiometry: 1.0
species: 326891

326481
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Phosphocreatine_C4H9N3O5P

322879
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-Linolenic acid, C18:3, n-3_C18H29O2

308753
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: ADPribose_C15H21N5O14P2

974530
type: Reaction
reactant: 406156
reactant: 406168
product: 406192
fast: false
is: ENSRNOG00000017084.2
notes: R_HSD11B2r subsystem: Steroid Metabolism R_HSD11B2r equation: [r] : cortsn + h + nadh <==> crtsl + nad
name: _11-beta-hydroxysteroid dehydrogenase type 2
reactant: 406144
reversible: true
product: 406180

406156
type: SpeciesReference
stoichiometry: 1.0
species: 319026

406168
type: SpeciesReference
stoichiometry: 1.0
species: 311918

311918
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Cortisone_C21H28O5

406192
type: SpeciesReference
stoichiometry: 1.0
species: 324724

406144
type: SpeciesReference
stoichiometry: 1.0
species: 324773

406180
type: SpeciesReference
stoichiometry: 1.0
species: 312122

312122
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Cortisol_C21H30O5

304244
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _17alpha-Hydroxypregnenolone_C21H32O3

327784
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Prostaglandin I2_C20H31O5

316468
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: VI2Fuc-nLc6_C64H112N3O36FULLRCO

968963
type: Reaction
notes: R_L_DASH_LACtcm subsystem: Transport, Mitochondrial R_L_DASH_LACtcm equation: lac-L[c] --> lac-L[m] R_UREAtm subsystem: Urea cycle/amino group metabolism R_UREAtm equation: urea[c] <==> urea[m]
is: ENSRNOG00000015949.3
fast: false
reversible: false
product: 351950
modifier: 351974
modifier: 351962
reactant: 351938

351950
type: SpeciesReference
stoichiometry: 1.0
species: 322349

331259
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Urea_CH4N2O

351938
type: SpeciesReference
stoichiometry: 1.0
species: 322323

319966
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 8_C69H100N4O81S8

311771
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Coenzyme A_C21H32N7O16P3S

312278
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate A (GalNAc4S-GlcA), free chain_C45H67N2O46S3

318282
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: GMP_C10H12N5O8P

969455
type: Reaction
product: 356166
reactant: 356154
notes: R_MAN6PI subsystem: Fructose and Mannose Metabolism R_MAN6PI equation: [c] : man6p <==> f6p
is: ENSRNOG00000018898.3
is: http://identifiers.org/ec-code/5.3.1.8
fast: false
reversible: true
name: mannose-6-phosphate isomerase

356166
type: SpeciesReference
stoichiometry: 1.0
species: 315708

356154
type: SpeciesReference
stoichiometry: 1.0
species: 323738

309816
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: arachidyl coenzyme A_C41H70N7O17P3S

974146
type: Reaction
name: L-ascorbate transport via proton symport
is: ENSRNOG00000026919.3
reversible: true
is: ENSRNOG00000021262.3
reactant: 401897
product: 401934
is: ENSRNOG00000019938.3
reactant: 401910
fast: false
product: 401922
notes: R_ASCBt4 subsystem: Transport, Extracellular R_ASCBt4 equation: ascb-L[e] + na1[e] <==> ascb-L[c] + na1[c]

401897
type: SpeciesReference
stoichiometry: 1.0
species: 324628

401934
type: SpeciesReference
stoichiometry: 1.0
species: 310009

310009
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Ascorbate_C6H8O6

401910
type: SpeciesReference
stoichiometry: 1.0
species: 310021

310021
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Ascorbate_C6H8O6

401922
type: SpeciesReference
stoichiometry: 1.0
species: 324616

976463
type: Reaction
is: ENSRNOG00000036677.1
product: 422883
reactant: 422640
reactant: 422750
product: 422847
is: ENSRNOG00000007839.4
reactant: 422628
reactant: 422664
notes: R_L_DASH_LACtm subsystem: Transport, Mitochondrial R_L_DASH_LACtm equation: h[c] + lac-L[c] <==> h[m] + lac-L[m] R_D_DASH_LACt2 subsystem: Transport, Extracellular R_D_DASH_LACt2 equation: h[e] + lac-D[e] <==> h[c] + lac-D[c] R_PYRt2m subsystem: Transport, Mitochondrial R_PYRt2m equation: h[c] + pyr[c] <==> h[m] + pyr[m] R_ACACt2m subsystem: Transport, Mitochondrial R_ACACt2m equation: acac[c] + h[c] <==> acac[m] + h[m] R_L_DASH_LACt2r subsystem: Transport, Extracellular R_L_DASH_LACt2r equation: h[e] + lac-L[e] <==> h[c] + lac-L[c] R_ACETONEt2m subsystem: Transport, Mitochondrial R_ACETONEt2m equation: acetone[c] + h[c] <==> acetone[m] + h[m] R_ACACt2 subsystem: Transport, Extracellular R_ACACt2 equation: acac[e] + h[e] <==> acac[c] + h[c] R_PYRt2r subsystem: Transport, Extracellular R_PYRt2r equation: h[e] + pyr[e] <==> h[c] + pyr[c] R_ACETONEt2 subsystem: Transport, Extracellular R_ACETONEt2 equation: acetone[e] + h[e] <==> acetone[c] + h[c] R_BUTt2m subsystem: Transport, Mitochondrial R_BUTt2m equation: but[c] + h[c] <==> but[m] + h[m] R_PYRt2p subsystem: D-alanine metabolism R_PYRt2p equation: h[c] + pyr[c] <==> h[x] + pyr[x] R_2HBt2 subsystem: Transport, Extracellular R_2HBt2 equation: _2hb[e] + h[e] <==> 2hb[c] + h[c] R_BTNt2m subsystem: Transport, Mitochondrial R_BTNt2m equation: btn[c] + h[c] <==> btn[m] + h[m] R_BUTt2r subsystem: Transport, Extracellular R_BUTt2r equation: but[e] + h[e] <==> but[c] + h[c] R_BTNt2 subsystem: Transport, Extracellular R_BTNt2 equation: btn[e] + h[e] <==> btn[c] + h[c] R_D_DASH_LACtm subsystem: Transport, Mitochondrial R_D_DASH_LACtm equation: h[c] + lac-D[c] <==> h[m] + lac-D[m]
product: 423003
reactant: 422774
reactant: 422689
reactant: 422798
product: 423027
product: 422967
product: 422955
product: 422919
product: 422822
reactant: 422702
product: 423015
product: 422979
product: 422991
product: 422907
reactant: 422677
reactant: 422726
is: ENSRNOG00000019996.3
product: 422943
reversible: true
reactant: 422616
fast: false
reactant: 422652
reactant: 422762
product: 422931
reactant: 422714
product: 422835
reactant: 422786
product: 422871
reactant: 422738
reactant: 422810
product: 423039
product: 422859
product: 422895

422883
type: SpeciesReference
stoichiometry: 1.0
species: 310540

310540
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Biotin_C10H15N2O3S

422640
type: SpeciesReference
stoichiometry: 1.0
species: 322336

322336
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Lactate_C3H5O3

422750
type: SpeciesReference
stoichiometry: 1.0
species: 322323

422847
type: SpeciesReference
stoichiometry: 1.0
species: 307909

422628
type: SpeciesReference
stoichiometry: 8.0
species: 318966

422664
type: SpeciesReference
stoichiometry: 1.0
species: 310528

310528
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Biotin_C10H15N2O3S

423003
type: SpeciesReference
stoichiometry: 1.0
species: 322287

422774
type: SpeciesReference
stoichiometry: 1.0
species: 328073

328073
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Pyruvate_C3H3O3

422689
type: SpeciesReference
stoichiometry: 2.0
species: 328061

422798
type: SpeciesReference
stoichiometry: 1.0
species: 310576

423027
type: SpeciesReference
stoichiometry: 7.0
species: 319002

422967
type: SpeciesReference
stoichiometry: 1.0
species: 307729

422955
type: SpeciesReference
stoichiometry: 1.0
species: 307933

307933
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Acetone_C3H6O

422919
type: SpeciesReference
stoichiometry: 1.0
species: 310564

310564
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Butyrate (n-C4:0)_C4H7O2

422822
type: SpeciesReference
stoichiometry: 1.0
species: 304617

422702
type: SpeciesReference
stoichiometry: 1.0
species: 310516

310516
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Biotin_C10H15N2O3S

423015
type: SpeciesReference
stoichiometry: 8.0
species: 318954

422979
type: SpeciesReference
stoichiometry: 1.0
species: 328085

422991
type: SpeciesReference
stoichiometry: 1.0
species: 322349

422907
type: SpeciesReference
stoichiometry: 1.0
species: 322311

422677
type: SpeciesReference
stoichiometry: 1.0
species: 307909

422726
type: SpeciesReference
stoichiometry: 1.0
species: 304629

304629
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _2-Hydroxybutyrate_C4H7O3

422943
type: SpeciesReference
stoichiometry: 1.0
species: 322323

422616
type: SpeciesReference
stoichiometry: 1.0
species: 307921

422652
type: SpeciesReference
stoichiometry: 1.0
species: 322299

322299
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Lactate_C3H5O3

422762
type: SpeciesReference
stoichiometry: 1.0
species: 307729

422931
type: SpeciesReference
stoichiometry: 1.0
species: 319038

422714
type: SpeciesReference
stoichiometry: 1.0
species: 307741

307741
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Acetoacetate_C4H5O3

422835
type: SpeciesReference
stoichiometry: 1.0
species: 307753

422786
type: SpeciesReference
stoichiometry: 1.0
species: 322287

422871
type: SpeciesReference
stoichiometry: 1.0
species: 310588

422738
type: SpeciesReference
stoichiometry: 1.0
species: 310564

422810
type: SpeciesReference
stoichiometry: 8.0
species: 318954

423039
type: SpeciesReference
stoichiometry: 1.0
species: 328097

328097
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Pyruvate_C3H3O3

422859
type: SpeciesReference
stoichiometry: 1.0
species: 328061

422895
type: SpeciesReference
stoichiometry: 1.0
species: 310516

973498
type: Reaction
reactant: 393338
fast: false
name: L-glutamate reversible transport via proton symport, mitochondrial
reversible: true
is: ENSRNOG00000011566.4
product: 393363
reactant: 393326
product: 393350
notes: R_GLUt2m subsystem: Transport, Mitochondrial R_GLUt2m equation: glu-L[c] + h[c] <==> glu-L[m] + h[m]
is: ENSRNOG00000018450.4

393338
type: SpeciesReference
stoichiometry: 1.0
species: 318954

393363
type: SpeciesReference
stoichiometry: 1.0
species: 319002

393326
type: SpeciesReference
stoichiometry: 1.0
species: 317683

393350
type: SpeciesReference
stoichiometry: 1.0
species: 317722

970785
type: Reaction
is: ENSRNOG00000000165.4
product: 367762
reactant: 367688
is: ENSRNOG00000018911.4
reactant: 367713
reversible: false
is: ENSRNOG00000004162.4
notes: R_FBP26 subsystem: Fructose and Mannose Metabolism R_FBP26 equation: [c] : f26bp + h2o --> f6p + pi R_PFK26 subsystem: Fructose and Mannose Metabolism R_PFK26 equation: [c] : atp + f6p --> adp + f26bp + h
is: http://identifiers.org/ec-code/3.1.3.46
product: 367774
reactant: 367700
product: 367726
product: 367750
is: http://identifiers.org/ec-code/2.7.1.105
is: ENSRNOG00000020656.3
reactant: 367676
product: 367738
fast: false

367762
type: SpeciesReference
stoichiometry: 1.0
species: 315708

367688
type: SpeciesReference
stoichiometry: 1.0
species: 310142

367713
type: SpeciesReference
stoichiometry: 1.0
species: 318846

367774
type: SpeciesReference
stoichiometry: 1.0
species: 318954

367700
type: SpeciesReference
stoichiometry: 1.0
species: 315708

367726
type: SpeciesReference
stoichiometry: 1.0
species: 315684

367750
type: SpeciesReference
stoichiometry: 1.0
species: 308621

367676
type: SpeciesReference
stoichiometry: 1.0
species: 315684

367738
type: SpeciesReference
stoichiometry: 1.0
species: 326891

319710
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 12_C55H82N3O64S6

305472
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Phospho-D-glycerate_C3H4O7P

970324
type: Reaction
reversible: false
product: 363464
product: 363416
reactant: 363379
product: 363440
product: 363452
is: ENSRNOG00000016381.4
fast: false
reactant: 363391
reactant: 363367
notes: R_S2T1g subsystem: Chondroitin / heparan sulfate biosynthesis R_S2T1g equation: [g] : cs_c,d,e_pre1 + paps --> cs_d_pre2 + h + pap R_S2T2g subsystem: Chondroitin / heparan sulfate biosynthesis R_S2T2g equation: [g] : cs_d_pre5 + paps --> cspg_d + h + pap R_S2T3g subsystem: Chondroitin / heparan sulfate biosynthesis R_S2T3g equation: [g] : cs_b_pre5 + paps --> cspg_b + h + pap
reactant: 363404
product: 363428

363464
type: SpeciesReference
stoichiometry: 1.0
species: 312832

312832
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) proteoglycan_C45H64N2O51S5X

363416
type: SpeciesReference
stoichiometry: 3.0
species: 318978

363379
type: SpeciesReference
stoichiometry: 3.0
species: 326385

363440
type: SpeciesReference
stoichiometry: 1.0
species: 312808

312808
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate B / dermatan sulfate (IdoA2S-GalNAc4S) proteoglycan_C45H65N2O48S4X

363452
type: SpeciesReference
stoichiometry: 3.0
species: 326361

363391
type: SpeciesReference
stoichiometry: 1.0
species: 312591

363367
type: SpeciesReference
stoichiometry: 1.0
species: 312363

363404
type: SpeciesReference
stoichiometry: 1.0
species: 312351

363428
type: SpeciesReference
stoichiometry: 1.0
species: 312555

312555
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate D (GlcNAc6S-GlcA2S) precursor 2_C31H46NO34S3X

309082
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _1-alkyl 2-lysoglycerol 3-phosphocholine_C10H21O5NPFULLR

326445
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Phosphatidylcholine (homo sapiens)_C8H18NO4PFULLRCO2FULLR2CO2

977219
type: Reaction
name: uroporphyrinogen-III synthase
reversible: false
is: http://identifiers.org/ec-code/4.2.1.75
product: 431694
notes: R_UPP3S subsystem: Heme Biosynthesis R_UPP3S equation: [c] : hmbil --> h2o + uppg3
reactant: 431670
fast: false
is: ENSRNOG00000017810.2
product: 431682

431694
type: SpeciesReference
stoichiometry: 1.0
species: 318846

431670
type: SpeciesReference
stoichiometry: 1.0
species: 319494

431682
type: SpeciesReference
stoichiometry: 1.0
species: 331175

326951
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Phosphate_HO4P

976703
type: Reaction
reactant: 425114
product: 425236
reactant: 425042
reactant: 425030
reactant: 424981
product: 425187
product: 425322
product: 425346
product: 425273
reactant: 425151
product: 425383
is: http://identifiers.org/ec-code/3.1.6.14
reactant: 425018
product: 425297
reactant: 424993
product: 425163
is: ENSRNOG00000004919.4
product: 425309
reactant: 425066
reactant: 425102
product: 425199
reactant: 425078
product: 425371
reactant: 424969
product: 425358
notes: R_S6TASE23ly subsystem: Keratan sulfate degradation R_S6TASE23ly equation: [l] : h2o + ksii_core2_deg3 <==> h + ksii_core2_deg4 + so4 R_S6TASE15ly subsystem: Keratan sulfate degradation R_S6TASE15ly equation: [l] : h2o + ksi_deg18 <==> h + ksi_deg19 + so4 R_S6TASE13ly subsystem: Keratan sulfate degradation R_S6TASE13ly equation: [l] : h2o + ksi_deg12 <==> h + ksi_deg13 + so4 R_S6TASE26ly subsystem: Keratan sulfate degradation R_S6TASE26ly equation: [l] : h2o + ksii_core4_deg3 <==> h + ksii_core4_deg4 + so4 R_S6TASE12ly subsystem: Keratan sulfate degradation R_S6TASE12ly equation: [l] : h2o + ksi_deg9 <==> h + ksi_deg10 + so4 R_S6TASE20ly subsystem: Keratan sulfate degradation R_S6TASE20ly equation: [l] : h2o + ksi_deg33 <==> h + ksi_deg34 + so4 R_S6TASE17ly subsystem: Keratan sulfate degradation R_S6TASE17ly equation: [l] : h2o + ksi_deg24 <==> h + ksi_deg25 + so4 R_S6TASE21ly subsystem: Keratan sulfate degradation R_S6TASE21ly equation: [l] : h2o + ksi_deg36 <==> h + ksi_deg37 + so4 R_S6TASE11ly subsystem: Keratan sulfate degradation R_S6TASE11ly equation: [l] : h2o + ksi_deg6 <==> h + ksi_deg7 + so4 R_S6TASE3ly subsystem: Heparan sulfate degradation R_S6TASE3ly equation: [l] : h2o + hs_deg11 <==> h + hs_deg12 + so4 R_S6TASE1ly subsystem: Heparan sulfate degradation R_S6TASE1ly equation: [l] : h2o + hs <==> h + hs_deg1 + so4 R_S6TASE24ly subsystem: Keratan sulfate degradation R_S6TASE24ly equation: [l] : h2o + ksii_core2_deg6 <==> h + ksii_core2_deg7 + so4 R_S6TASE2ly subsystem: Heparan sulfate degradation R_S6TASE2ly equation: [l] : h2o + hs_deg5 <==> h + hs_deg6 + so4 R_S6TASE16ly subsystem: Keratan sulfate degradation R_S6TASE16ly equation: [l] : h2o + ksi_deg21 <==> h + ksi_deg22 + so4 R_S6TASE14ly subsystem: Keratan sulfate degradation R_S6TASE14ly equation: [l] : h2o + ksi_deg15 <==> h + ksi_deg16 + so4 R_S6TASE19ly subsystem: Keratan sulfate degradation R_S6TASE19ly equation: [l] : h2o + ksi_deg30 <==> h + ksi_deg31 + so4 R_S6TASE18ly subsystem: Keratan sulf…
reactant: 425005
product: 425285
fast: false
reactant: 424957
reactant: 425090
product: 425224
product: 425211
product: 425248
reactant: 425138
product: 425175
product: 425334
product: 425261
reversible: true
reactant: 425054
reactant: 425126
reactant: 424945

425114
type: SpeciesReference
stoichiometry: 1.0
species: 321089

321089
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 30_C90H147N6O75S3

425236
type: SpeciesReference
stoichiometry: 1.0
species: 320812

320812
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 10_C188H302N13O163S9

425042
type: SpeciesReference
stoichiometry: 1.0
species: 321308

321308
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 9_C188H301N13O166S10

425030
type: SpeciesReference
stoichiometry: 17.0
species: 318882

424981
type: SpeciesReference
stoichiometry: 1.0
species: 320908

320908
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 18_C146H235N10O127S7

425187
type: SpeciesReference
stoichiometry: 1.0
species: 321053

425322
type: SpeciesReference
stoichiometry: 1.0
species: 319710

425346
type: SpeciesReference
stoichiometry: 1.0
species: 321174

321174
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 37_C62H104N4O46

425273
type: SpeciesReference
stoichiometry: 1.0
species: 321101

321101
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 31_C90H148N6O72S2

425151
type: SpeciesReference
stoichiometry: 1.0
species: 321271

321271
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 6_C210H336N15O184S11

425383
type: SpeciesReference
stoichiometry: 1.0
species: 320921

320921
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 19_C146H236N10O124S6

425018
type: SpeciesReference
stoichiometry: 1.0
species: 320836

425297
type: SpeciesReference
stoichiometry: 1.0
species: 321829

321829
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 2-linked), degradation product 4_C58H95N5O43SX

424993
type: SpeciesReference
stoichiometry: 1.0
species: 321853

321853
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 2-linked), degradation product 6_C44H72N4O33SX

425163
type: SpeciesReference
stoichiometry: 1.0
species: 320848

425309
type: SpeciesReference
stoichiometry: 1.0
species: 322082

322082
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 4-linked), degradation product 4_C66H108N6O48SX

425066
type: SpeciesReference
stoichiometry: 1.0
species: 320872

425102
type: SpeciesReference
stoichiometry: 1.0
species: 319991

319991
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, free chain_C79H114N5O102S12

425199
type: SpeciesReference
stoichiometry: 1.0
species: 320981

320981
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 22_C132H214N9O111S5

425078
type: SpeciesReference
stoichiometry: 1.0
species: 321817

321817
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 2-linked), degradation product 3_C58H94N5O46S2X

425371
type: SpeciesReference
stoichiometry: 1.0
species: 321017

321017
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 25_C118H192N8O98S4

424969
type: SpeciesReference
stoichiometry: 1.0
species: 322070

322070
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 4-linked), degradation product 3_C66H107N6O51S2X

425358
type: SpeciesReference
stoichiometry: 1.0
species: 321865

425005
type: SpeciesReference
stoichiometry: 1.0
species: 321005

321005
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 24_C118H191N8O101S5

425285
type: SpeciesReference
stoichiometry: 1.0
species: 320884

320884
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 16_C160H258N11O137S7

424957
type: SpeciesReference
stoichiometry: 1.0
species: 319698

319698
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 11_C55H81N3O67S7

425090
type: SpeciesReference
stoichiometry: 1.0
species: 321041

321041
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 27_C104H169N7O88S4

425224
type: SpeciesReference
stoichiometry: 1.0
species: 321138

321138
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 34_C76H126N5O59S1

425211
type: SpeciesReference
stoichiometry: 1.0
species: 321284

321284
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 7_C210H337N15O181S10

425248
type: SpeciesReference
stoichiometry: 17.0
species: 318990

318990
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: H+_H

425138
type: SpeciesReference
stoichiometry: 1.0
species: 321126

425175
type: SpeciesReference
stoichiometry: 17.0
species: 328917

425334
type: SpeciesReference
stoichiometry: 1.0
species: 319941

425261
type: SpeciesReference
stoichiometry: 1.0
species: 319806

425054
type: SpeciesReference
stoichiometry: 1.0
species: 321162

321162
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 36_C62H103N4O49S1

425126
type: SpeciesReference
stoichiometry: 1.0
species: 320969

320969
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 21_C132H213N9O114S6

424945
type: SpeciesReference
stoichiometry: 1.0
species: 319929

319929
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 5_C67H97N4O86S10

971552
type: Reaction
reactant: 374143
product: 374420
fast: false
product: 374264
product: 374360
reactant: 374180
reactant: 374192
reactant: 374083
product: 374276
reversible: false
reactant: 374095
reactant: 374216
product: 374240
reactant: 374228
product: 374432
product: 374336
reactant: 374155
product: 374456
product: 374312
reactant: 374168
product: 374481
product: 374252
reactant: 374071
product: 374408
product: 374396
reactant: 374107
reactant: 374204
reactant: 374011
product: 374348
reactant: 374047
notes: R_B3GNT11g subsystem: Blood Group Biosynthesis R_B3GNT11g equation: [g] : gal14acglcgalgluside_hs + uacgam --> acglcgal14acglcgalgluside_hs + h + udp R_AG13T6g subsystem: Keratan sulfate biosynthesis R_AG13T6g equation: [g] : ksi_pre6 + uacgam --> h + ksi_pre7 + udp R_AG13T17g subsystem: Keratan sulfate biosynthesis R_AG13T17g equation: [g] : ksii_core4_pre4 + uacgam --> h + ksii_core4_pre5 + udp R_B3GNT12g subsystem: Blood Group Biosynthesis R_B3GNT12g equation: [g] : galacglcgal14acglcgalgluside_hs + uacgam --> acglc13galacglcgal14acglcgalgluside_hs + h + udp R_AG13T2g subsystem: Keratan sulfate biosynthesis R_AG13T2g equation: [g] : ksii_core2_pre4 + uacgam --> h + ksii_core2_pre5 + udp R_AG13T5g subsystem: Keratan sulfate biosynthesis R_AG13T5g equation: [g] : ksi_pre3 + uacgam --> h + ksi_pre4 + udp R_AG13T8g subsystem: Keratan sulfate biosynthesis R_AG13T8g equation: [g] : ksi_pre12 + uacgam --> h + ksi_pre13 + udp R_AG13T12g subsystem: Keratan sulfate biosynthesis R_AG13T12g equation: [g] : ksi_pre24 + uacgam --> h + ksi_pre25 + udp R_AG13T1g subsystem: Keratan sulfate biosynthesis R_AG13T1g equation: [g] : ksii_core2_pre2 + uacgam --> h + ksii_core2_pre3 + udp R_AG13T10g subsystem: Keratan sulfate biosynthesis R_AG13T10g equation: [g] : ksi_pre18 + uacgam --> h + ksi_pre19 + udp R_AG13T14g subsystem: Keratan sulfate biosynthesis R_AG13T14g equation: [g] : ksi_pre30 + uacgam --> h + ksi_pre31 + udp R_AG13T13g subsystem: Keratan sulfate biosynthesis R_AG13T13g equation: [g] : ksi_pre27 + uacgam --> h + ksi_pre28 + udp R_AG13T9g subsystem: Keratan sulfate biosynthesis R_AG13T9g equation: [g] : ksi_pre15 + uacgam --> h + ksi_pre16 + udp R_AG13T15g subsystem: Keratan sulfate biosynthesis R_AG13T15g equation: [g] : ksi_pre33 + uacgam --> h + ksi_pre34 + udp R_AG13T4g subsystem: Keratan sulfate biosynthesis R_AG13T4g equation: [g] : ksi_pre1 + uacgam --> h + ksi_pre2 + udp R_AG13T11g subsystem: Keratan sulfate biosynthesis R_AG13T11g equation: [g] : ksi_pre21 + uac…
reactant: 374059
product: 374372
is: ENSRNOG00000009267.3
product: 374444
product: 374288
product: 374469
reactant: 374119
product: 374324
reactant: 374023
is: http://identifiers.org/ec-code/2.4.1.149
product: 374384
product: 374300
reactant: 373987
product: 374493
reactant: 374035
reactant: 373999
reactant: 374131

374143
type: SpeciesReference
stoichiometry: 1.0
species: 321417

374420
type: SpeciesReference
stoichiometry: 1.0
species: 321961

374264
type: SpeciesReference
stoichiometry: 1.0
species: 322215

374360
type: SpeciesReference
stoichiometry: 1.0
species: 321985

374180
type: SpeciesReference
stoichiometry: 1.0
species: 322167

374192
type: SpeciesReference
stoichiometry: 1.0
species: 316890

374083
type: SpeciesReference
stoichiometry: 20.0
species: 330814

374276
type: SpeciesReference
stoichiometry: 1.0
species: 321634

374095
type: SpeciesReference
stoichiometry: 1.0
species: 321658

374216
type: SpeciesReference
stoichiometry: 1.0
species: 321745

374240
type: SpeciesReference
stoichiometry: 1.0
species: 322155

374228
type: SpeciesReference
stoichiometry: 1.0
species: 321501

374432
type: SpeciesReference
stoichiometry: 1.0
species: 321393

374336
type: SpeciesReference
stoichiometry: 1.0
species: 321357

374155
type: SpeciesReference
stoichiometry: 1.0
species: 321949

374456
type: SpeciesReference
stoichiometry: 1.0
species: 322179

374312
type: SpeciesReference
stoichiometry: 20.0
species: 330850

374168
type: SpeciesReference
stoichiometry: 1.0
species: 322143

374481
type: SpeciesReference
stoichiometry: 1.0
species: 321429

374252
type: SpeciesReference
stoichiometry: 1.0
species: 321550

374071
type: SpeciesReference
stoichiometry: 1.0
species: 321477

374408
type: SpeciesReference
stoichiometry: 1.0
species: 308151

374396
type: SpeciesReference
stoichiometry: 1.0
species: 321610

374107
type: SpeciesReference
stoichiometry: 1.0
species: 321781

374204
type: SpeciesReference
stoichiometry: 1.0
species: 321973

374011
type: SpeciesReference
stoichiometry: 1.0
species: 321574

374348
type: SpeciesReference
stoichiometry: 1.0
species: 308163

374047
type: SpeciesReference
stoichiometry: 1.0
species: 321537

374059
type: SpeciesReference
stoichiometry: 1.0
species: 321381

374372
type: SpeciesReference
stoichiometry: 1.0
species: 322021

374444
type: SpeciesReference
stoichiometry: 1.0
species: 321721

374288
type: SpeciesReference
stoichiometry: 1.0
species: 321586

374469
type: SpeciesReference
stoichiometry: 1.0
species: 321670

374119
type: SpeciesReference
stoichiometry: 1.0
species: 321453

374324
type: SpeciesReference
stoichiometry: 20.0
species: 318978

374023
type: SpeciesReference
stoichiometry: 1.0
species: 321708

374384
type: SpeciesReference
stoichiometry: 1.0
species: 321513

374300
type: SpeciesReference
stoichiometry: 1.0
species: 321757

373987
type: SpeciesReference
stoichiometry: 1.0
species: 321622

374493
type: SpeciesReference
stoichiometry: 1.0
species: 321465

374035
type: SpeciesReference
stoichiometry: 1.0
species: 322203

373999
type: SpeciesReference
stoichiometry: 1.0
species: 316792

374131
type: SpeciesReference
stoichiometry: 1.0
species: 322009

968265
type: Reaction
fast: false
reactant: 345218
product: 345302
is: http://identifiers.org/ec-code/2.7.1.7
reactant: 345242
product: 345278
product: 345338
notes: R_HEX10 subsystem: Aminosugar Metabolism R_HEX10 equation: [c] : atp + gam --> adp + gam6p + h R_HEX4 subsystem: Fructose and Mannose Metabolism R_HEX4 equation: [c] : atp + man --> adp + h + man6p R_HEX7 subsystem: Fructose and Mannose Metabolism R_HEX7 equation: [c] : atp + fru --> adp + f6p + h R_HEX1 subsystem: Glycolysis/Gluconeogenesis R_HEX1 equation: [c] : atp + glc-D --> adp + g6p + h
product: 345290
reactant: 345230
is: http://identifiers.org/ec-code/2.7.1.1
reactant: 345266
product: 345314
is: ENSRNOG00000006116.2
reversible: false
reactant: 345254
is: ENSRNOG00000026235.1
product: 345326
is: ENSRNOG00000014447.4

345218
type: SpeciesReference
stoichiometry: 4.0
species: 310142

345302
type: SpeciesReference
stoichiometry: 4.0
species: 308621

345242
type: SpeciesReference
stoichiometry: 1.0
species: 316165

345278
type: SpeciesReference
stoichiometry: 1.0
species: 317107

345338
type: SpeciesReference
stoichiometry: 4.0
species: 318954

345290
type: SpeciesReference
stoichiometry: 1.0
species: 316720

345230
type: SpeciesReference
stoichiometry: 1.0
species: 323751

323751
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Mannose_C6H12O6

345266
type: SpeciesReference
stoichiometry: 1.0
species: 317507

345314
type: SpeciesReference
stoichiometry: 1.0
species: 315708

345254
type: SpeciesReference
stoichiometry: 1.0
species: 317119

317119
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Glucosamine_C6H14NO5

345326
type: SpeciesReference
stoichiometry: 1.0
species: 323738

971828
type: Reaction
fast: false
is: ENSRNOG00000028368.3
notes: R_ETHAK subsystem: Glycerophospholipid Metabolism R_ETHAK equation: [c] : atp + etha --> adp + ethamp + h
name: Ethanolamine kinase
product: 378911
product: 378898
reversible: false
reactant: 378874
reactant: 378862
is: http://identifiers.org/ec-code/2.7.1.82
is: ENSRNOG00000014856.3
product: 378886

378911
type: SpeciesReference
stoichiometry: 1.0
species: 318954

378898
type: SpeciesReference
stoichiometry: 1.0
species: 308621

378874
type: SpeciesReference
stoichiometry: 1.0
species: 310142

378862
type: SpeciesReference
stoichiometry: 1.0
species: 315600

315600
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Ethanolamine_C2H8NO

378886
type: SpeciesReference
stoichiometry: 1.0
species: 315612

315672
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Fructose 1-phosphate_C6H11O9P

322447
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Lactose_C12H22O11

306039
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Pyridoxate_C8H9NO4

968181
type: Reaction
reactant: 344662
is: ENSRNOG00000019213.4
is: ENSRNOG00000004906.4
product: 344686
is: ENSRNOG00000025214.3
product: 344710
notes: R_G3PD1 subsystem: Glycerophospholipid Metabolism R_G3PD1 equation: [c] : glyc3p + nad <==> dhap + h + nadh
fast: false
product: 344698
is: http://identifiers.org/ec-code/1.1.1.94
reactant: 344674
name: glycerol-3-phosphate dehydrogenase (NAD)
reversible: true

344662
type: SpeciesReference
stoichiometry: 1.0
species: 324676

344686
type: SpeciesReference
stoichiometry: 1.0
species: 313812

344710
type: SpeciesReference
stoichiometry: 1.0
species: 324749

344698
type: SpeciesReference
stoichiometry: 1.0
species: 318954

344674
type: SpeciesReference
stoichiometry: 1.0
species: 317967

973618
type: Reaction
is: ENSRNOG00000031139.2
fast: false
is: ENSRNOG00000031960.2
reactant: 394970
product: 395043
reversible: false
is: ENSRNOG00000029347.2
product: 395067
product: 395019
is: ENSRNOG00000030143.2
product: 394994
reactant: 394958
is: ENSRNOG00000031439.2
reactant: 394982
reactant: 394946
is: ENSRNOG00000019578.4
reactant: 394934
notes: R_PSFLIP subsystem: Transport, Extracellular R_PSFLIP equation: atp[c] + h2o[c] + ps_hs[e] --> adp[c] + h[c] + pi[c] + ps_hs[c] R_PEFLIP subsystem: Transport, Extracellular R_PEFLIP equation: atp[c] + h2o[c] + pe_hs[e] --> adp[c] + h[c] + pe_hs[c] + pi[c] R_PSFLIPm subsystem: Transport, Mitochondrial R_PSFLIPm equation: atp[c] + h2o[c] + ps_hs[c] --> adp[c] + h[c] + pi[c] + ps_hs[m] R_PEFLIPm subsystem: Transport, Mitochondrial R_PEFLIPm equation: atp[c] + h2o[c] + pe_hs[c] --> adp[c] + h[c] + pe_hs[m] + pi[c]
product: 395031
reactant: 394922
is: ENSRNOG00000033041.2
product: 395055
product: 395007

394970
type: SpeciesReference
stoichiometry: 1.0
species: 327845

327845
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2

395043
type: SpeciesReference
stoichiometry: 1.0
species: 327857

327857
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2

395067
type: SpeciesReference
stoichiometry: 1.0
species: 327833

327833
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylserine (homo sapiens)_C6H11NO6PFULLRCO2FULLR2CO2

395019
type: SpeciesReference
stoichiometry: 1.0
species: 326542

326542
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2

394994
type: SpeciesReference
stoichiometry: 4.0
species: 326891

394958
type: SpeciesReference
stoichiometry: 4.0
species: 318846

394982
type: SpeciesReference
stoichiometry: 1.0
species: 327833

394946
type: SpeciesReference
stoichiometry: 1.0
species: 326554

326554
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2

394934
type: SpeciesReference
stoichiometry: 1.0
species: 326542

395031
type: SpeciesReference
stoichiometry: 4.0
species: 308621

394922
type: SpeciesReference
stoichiometry: 4.0
species: 310142

395055
type: SpeciesReference
stoichiometry: 4.0
species: 318954

395007
type: SpeciesReference
stoichiometry: 1.0
species: 326566

326566
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: phosphatidylethanolamine (homo sapiens)_C5H12NO4PFULLRCO2FULLR2CO2

330429
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Oxidized thioredoxin_X

975623
type: Reaction
fast: false
reactant: 415526
product: 415550
reversible: false
product: 415574
reactant: 415538
product: 415562
is: ENSRNOG00000028616.3
is: http://identifiers.org/ec-code/4.1.1.32
name: Phosphoenolpyruvate carboxykinase (GTP)
notes: R_PEPCK subsystem: Glycolysis/Gluconeogenesis R_PEPCK equation: [c] : gtp + oaa --> co2 + gdp + pep

415526
type: SpeciesReference
stoichiometry: 1.0
species: 325525

415550
type: SpeciesReference
stoichiometry: 1.0
species: 317349

415574
type: SpeciesReference
stoichiometry: 1.0
species: 311681

415538
type: SpeciesReference
stoichiometry: 1.0
species: 318666

415562
type: SpeciesReference
stoichiometry: 1.0
species: 326602

969623
type: Reaction
product: 357143
product: 357131
name: Squalene epoxidase, endoplasmic reticular (NADP)
reactant: 357094
is: ENSRNOG00000009550.4
reactant: 357106
product: 357118
reversible: false
notes: R_SQLEr subsystem: Cholesterol Metabolism R_SQLEr equation: [r] : h + nadph + o2 + sql --> Ssq23epx + h2o + nadp
is: http://identifiers.org/ec-code/1.14.99.7
reactant: 357082
fast: false
reactant: 357070

357143
type: SpeciesReference
stoichiometry: 1.0
species: 324845

357131
type: SpeciesReference
stoichiometry: 1.0
species: 318918

357094
type: SpeciesReference
stoichiometry: 1.0
species: 324905

357106
type: SpeciesReference
stoichiometry: 1.0
species: 319026

357118
type: SpeciesReference
stoichiometry: 1.0
species: 307524

357082
type: SpeciesReference
stoichiometry: 1.0
species: 329123

357070
type: SpeciesReference
stoichiometry: 1.0
species: 325440

972969
type: Reaction
fast: false
reactant: 388659
reactant: 388671
notes: R_NAHCO3_HCLt subsystem: Transport, Extracellular R_NAHCO3_HCLt equation: cl[c] + h[c] + hco3[e] + na1[e] <==> cl[e] + h[e] + hco3[c] + na1[c]
product: 388731
name: bicarbonate transport (HCl/NaHCO3 exchange)
reversible: true
reactant: 388695
is: ENSRNOG00000005307.4
product: 388707
product: 388743
is: ENSRNOG00000028879.2
product: 388719
reactant: 388683

388659
type: SpeciesReference
stoichiometry: 1.0
species: 311436

388671
type: SpeciesReference
stoichiometry: 1.0
species: 324628

388731
type: SpeciesReference
stoichiometry: 1.0
species: 324616

388695
type: SpeciesReference
stoichiometry: 1.0
species: 318954

388707
type: SpeciesReference
stoichiometry: 1.0
species: 319110

388743
type: SpeciesReference
stoichiometry: 1.0
species: 311448

388719
type: SpeciesReference
stoichiometry: 1.0
species: 318966

388683
type: SpeciesReference
stoichiometry: 1.0
species: 319122

325186
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Methylputrescine_C5H16N2

330935
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811

313607
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775

323371
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: (alpha-D-Mannosyl)6-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol, human liver homolog_C1660H2728N20O520P20

319917
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heparan sulfate, degradation product 4_C73H104N4O92S10

331490
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Vitamin D3_C27H44O

317095
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Gal-Gal-Gal-Glc-Cer (homo sapiens)_C42H76NO22FULLRCO

306955
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: protein-linked asparagine residue (N-glycosylation site)_XH

976691
type: Reaction
product: 424933
is: ENSRNOG00000014117.4
product: 424909
product: 424885
reversible: false
is: ENSRNOG00000003773.3
notes: R_HOXG subsystem: Heme Degradation R_HOXG equation: [c] : (5) h + (3) nadph + (3) o2 + pheme --> biliverd + co + fe2 + (3) h2o + (3) nadp
reactant: 424873
reactant: 424861
reactant: 424849
product: 424897
fast: false
name: Heme oxygenase 1
reactant: 424837
is: http://identifiers.org/ec-code/1.14.99.3
product: 424921

424933
type: SpeciesReference
stoichiometry: 1.0
species: 310420

424909
type: SpeciesReference
stoichiometry: 3.0
species: 324797

424885
type: SpeciesReference
stoichiometry: 1.0
species: 311746

311746
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Carbon monoxide_CO

424873
type: SpeciesReference
stoichiometry: 3.0
species: 324869

424861
type: SpeciesReference
stoichiometry: 5.0
species: 318954

424849
type: SpeciesReference
stoichiometry: 3.0
species: 325392

424897
type: SpeciesReference
stoichiometry: 1.0
species: 315877

315877
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Fe2+_Fe

424837
type: SpeciesReference
stoichiometry: 1.0
species: 326759

424921
type: SpeciesReference
stoichiometry: 3.0
species: 318846

970362
type: Reaction
notes: R_COQ6m subsystem: Ubiquinone Biosynthesis R_COQ6m equation: [m] : 2dp6mep + o2 --> 2dp6mobq + h2o
is: ENSRNOG00000011164.4
reversible: false
fast: false
reactant: 363608
product: 363633
name: Ubiquinone biosynthesis monooxgenase COQ6
reactant: 363596
product: 363621

363608
type: SpeciesReference
stoichiometry: 1.0
species: 325416

363633
type: SpeciesReference
stoichiometry: 1.0
species: 304557

304557
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Decaprenyl-6-methoxy-1,4-benzoquinone_C57H86O3

363596
type: SpeciesReference
stoichiometry: 1.0
species: 304545

304545
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Decaprenyl-6-methoxyphenol_C57H88O2

363621
type: SpeciesReference
stoichiometry: 1.0
species: 318894

323686
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Maltotriose_C18H32O16

314367
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2,6 dimethylheptanoyl-CoA_C30H52N7O17P3S

969551
type: Reaction
reactant: 356696
notes: R_FCLTm subsystem: Heme Biosynthesis R_FCLTm equation: [m] : fe2 + ppp9 --> (2) h + pheme
reactant: 356708
is: http://identifiers.org/ec-code/4.99.1.1
fast: false
is: ENSRNOG00000016885.3
name: Ferrochelatase, mitochondrial
product: 356732
product: 356720
reversible: false

356696
type: SpeciesReference
stoichiometry: 1.0
species: 327266

327266
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Protoporphyrin_C34H32N4O4

356708
type: SpeciesReference
stoichiometry: 1.0
species: 315901

356732
type: SpeciesReference
stoichiometry: 2.0
species: 319002

356720
type: SpeciesReference
stoichiometry: 1.0
species: 326783

326783
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Protoheme_C34H30FeN4O4

314175
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Digalactosylceramide_C30H56NO12FULLRCO

307813
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Acetaldehyde_C2H4O

971720
type: Reaction
notes: R_GALNACT1g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT1g equation: [g] : cs,hs_linkage + udpacgal --> cs_pre + h + udp R_GALNACT5g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT5g equation: [g] : cs_e_pre3 + uacgam --> cs_e_pre4 + h + udp R_GALNACT4g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT4g equation: [g] : cs_d_pre3 + uacgam --> cs_d_pre4 + h + udp R_GALNACT3g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT3g equation: [g] : cs_c_pre2 + uacgam --> cs_c_pre3 + h + udp R_GALNACT2g subsystem: Chondroitin / heparan sulfate biosynthesis R_GALNACT2g equation: [g] : cs_a,b_pre2 + uacgam --> cs_a,b_pre3 + h + udp
fast: false
reactant: 377890
product: 377968
reactant: 377929
reactant: 377955
product: 378029
reactant: 377915
is: ENSRNOG00000013024.3
product: 378005
is: ENSRNOG00000014713.3
is: http://identifiers.org/ec-code/2.4.1.175
product: 377980
product: 378041
is: http://identifiers.org/ec-code/2.4.1.174
reactant: 377942
product: 377993
reversible: false
reactant: 377878
reactant: 377902
product: 378017

377890
type: SpeciesReference
stoichiometry: 1.0
species: 312447

312447
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 2_C37H54NO37S2X

377968
type: SpeciesReference
stoichiometry: 1.0
species: 312579

377929
type: SpeciesReference
stoichiometry: 1.0
species: 330923

377955
type: SpeciesReference
stoichiometry: 1.0
species: 312194

312194
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate A (GalNAc4S-GlcA) and B (IdoA2S-GalNAc4S), precursor 2_C37H54NO37S2X

378029
type: SpeciesReference
stoichiometry: 1.0
species: 312724

377915
type: SpeciesReference
stoichiometry: 1.0
species: 312711

312711
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), precursor 3_C37H52NO43S4X

378005
type: SpeciesReference
stoichiometry: 1.0
species: 312459

312459
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate C (GalNAc6S-GlcA), precursor 3_C45H67N2O42S2X

377980
type: SpeciesReference
stoichiometry: 5.0
species: 330850

378041
type: SpeciesReference
stoichiometry: 1.0
species: 312760

377942
type: SpeciesReference
stoichiometry: 1.0
species: 312170

377993
type: SpeciesReference
stoichiometry: 5.0
species: 318978

377878
type: SpeciesReference
stoichiometry: 1.0
species: 312567

312567
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: chondroitin sulfate D (GlcNAc6S-GlcA2S), precursor 3_C37H53NO40S3X

377902
type: SpeciesReference
stoichiometry: 4.0
species: 330814

378017
type: SpeciesReference
stoichiometry: 1.0
species: 312206

973510
type: Reaction
reactant: 393472
reactant: 393520
product: 393664
product: 393628
modifier: 393796
product: 393640
product: 393604
product: 393724
fast: false
product: 393580
product: 393592
reactant: 393376
product: 393556
modifier: 393772
reactant: 393388
modifier: 393784
is: http://identifiers.org/ec-code/1.2.1.21
reactant: 393400
is: http://identifiers.org/ec-code/1.2.1.3
reactant: 393412
reactant: 393508
product: 393700
modifier: 393760
reversible: false
reactant: 393448
product: 393676
reactant: 393424
is: http://identifiers.org/ec-code/1.5.1.12
product: 393688
modifier: 393736
reactant: 393436
product: 393652
product: 393616
modifier: 393748
is: ENSRNOG00000018608.4
product: 393712
reactant: 393484
product: 393568
reactant: 393532
reactant: 393496
reactant: 393544
reactant: 393460
notes: R_4HGLSDm subsystem: Arginine and Proline Metabolism R_4HGLSDm equation: [m] : 4hglusa + h2o + nad <==> e4hglu + (2) h + nadh R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_P5CDm subsystem: Glutamate metabolism R_P5CDm equation: [m] : 1pyr5c + (2) h2o + nad --> glu-L + h + nadh R_BAMPPALDOXm subsystem: beta-Alanine metabolism R_BAMPPALDOXm equation: [m] : bamppald + h2o + nad --> ala-B + (2) h + nadh R_NABTNOm subsystem: Arginine and Proline Metabolism R_NABTNOm equation: [m] : h2o + n4abutn + nad --> 4aabutn + (2) h + nadh R_HPROxm subsystem: Arginine and Proline Metabolism R_HPROxm equation: [m] : 4hpro-LT + nad --> 1p3h5c + (2) h + nadh R_PYLALDOXm subsystem: Limonene and pinene degradation R_PYLALDOXm equation: [m] : h2o + nad + pylald --> (2) h + nadh + peracd R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh R_IMACTD_m subsystem: Histidine Metabolism R_IMACTD_m equation: [m] : h2o + im4act + nad --> (2) h + im4ac + nadh R_ALDD20xm subsystem: Tryptophan metabolism R_ALDD20xm equation: [m] : h2o + id3acald + nad --> (2) h + ind3ac + nadh R_PHCDm subsystem: Arginine and Proline Metabolism R_PHCDm equation: [m] : 1p3h5c + (2) h2o + nad --> e4hglu + h + nadh R_5HOXINDACTOXm subsystem: Tryptophan metabolism R_5HOXINDACTOXm equation: [m] : 5hoxindact + h2o + nad --> 5hoxindoa + (2) h + nadh R_GLACOm subsystem: Ascorbate and Aldarate Metabolism R_GLACOm equation: [m] : glac + (2) h2o + nad --> glcr + (3) h + nadh

393472
type: SpeciesReference
stoichiometry: 1.0
species: 322373

393520
type: SpeciesReference
stoichiometry: 1.0
species: 322398

393664
type: SpeciesReference
stoichiometry: 1.0
species: 309190

393628
type: SpeciesReference
stoichiometry: 1.0
species: 317722

393640
type: SpeciesReference
stoichiometry: 1.0
species: 320572

393604
type: SpeciesReference
stoichiometry: 1.0
species: 315118

315118
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-erythro-4-Hydroxyglutamate_C5H8NO5

393724
type: SpeciesReference
stoichiometry: 13.0
species: 324761

393580
type: SpeciesReference
stoichiometry: 1.0
species: 318064

393592
type: SpeciesReference
stoichiometry: 1.0
species: 306415

393376
type: SpeciesReference
stoichiometry: 1.0
species: 310251

393556
type: SpeciesReference
stoichiometry: 1.0
species: 304365

393388
type: SpeciesReference
stoichiometry: 1.0
species: 304365

393400
type: SpeciesReference
stoichiometry: 15.0
species: 318894

393412
type: SpeciesReference
stoichiometry: 1.0
species: 324592

393508
type: SpeciesReference
stoichiometry: 1.0
species: 304389

393700
type: SpeciesReference
stoichiometry: 25.0
species: 319002

393448
type: SpeciesReference
stoichiometry: 1.0
species: 320368

393676
type: SpeciesReference
stoichiometry: 1.0
species: 320500

393424
type: SpeciesReference
stoichiometry: 1.0
species: 306391

393688
type: SpeciesReference
stoichiometry: 1.0
species: 322349

393436
type: SpeciesReference
stoichiometry: 1.0
species: 320524

393652
type: SpeciesReference
stoichiometry: 1.0
species: 326663

393616
type: SpeciesReference
stoichiometry: 1.0
species: 322311

305812
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-4-Hydroxyglutamate semialdehyde_C5H9NO4

393712
type: SpeciesReference
stoichiometry: 1.0
species: 317579

393484
type: SpeciesReference
stoichiometry: 1.0
species: 317494

393568
type: SpeciesReference
stoichiometry: 1.0
species: 305666

393532
type: SpeciesReference
stoichiometry: 13.0
species: 324700

393496
type: SpeciesReference
stoichiometry: 1.0
species: 328049

393544
type: SpeciesReference
stoichiometry: 1.0
species: 317192

393460
type: SpeciesReference
stoichiometry: 1.0
species: 305850

305850
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: trans-4-Hydroxy-L-proline_C5H9NO3

314247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: dITP_C10H11N4O13P3

976007
type: Reaction
reactant: 418549
reactant: 418525
reactant: 418513
reactant: 418561
product: 418597
product: 418609
fast: false
is: http://identifiers.org/ec-code/1.3.3.2
product: 418585
product: 418573
reactant: 418537
is: ENSRNOG00000008305.3
reversible: false
notes: R_LSTO1r subsystem: Cholesterol Metabolism R_LSTO1r equation: [r] : chlstol + h + nadph + o2 --> ddsmsterol + (2) h2o + nadp R_LSTO2r subsystem: Cholesterol Metabolism R_LSTO2r equation: [r] : h + lthstrl + nadph + o2 --> 7dhchsterol + (2) h2o + nadp

418549
type: SpeciesReference
stoichiometry: 2.0
species: 324905

418525
type: SpeciesReference
stoichiometry: 2.0
species: 325440

418513
type: SpeciesReference
stoichiometry: 1.0
species: 323059

418561
type: SpeciesReference
stoichiometry: 2.0
species: 319026

418597
type: SpeciesReference
stoichiometry: 2.0
species: 324845

418609
type: SpeciesReference
stoichiometry: 1.0
species: 306811

418585
type: SpeciesReference
stoichiometry: 1.0
species: 313559

418573
type: SpeciesReference
stoichiometry: 4.0
species: 318918

418537
type: SpeciesReference
stoichiometry: 1.0
species: 311024

968866
type: Reaction
fast: false
reactant: 350914
is: ENSRNOG00000012295.4
reactant: 350902
notes: R_PLA2_2 subsystem: Glycerophospholipid Metabolism R_PLA2_2 equation: [c] : h2o + pchol_hs --> Rtotal2 + h + lpchol_hs
product: 350938
is: http://identifiers.org/ec-code/3.1.1.4
name: phospholipase A2
product: 350950
reversible: false
product: 350926

350914
type: SpeciesReference
stoichiometry: 1.0
species: 318846

350902
type: SpeciesReference
stoichiometry: 1.0
species: 326397

350938
type: SpeciesReference
stoichiometry: 1.0
species: 307222

350950
type: SpeciesReference
stoichiometry: 1.0
species: 318954

350926
type: SpeciesReference
stoichiometry: 1.0
species: 323023

323023
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: lysophosphatidylcholine (homo sapiens)_C8H19NO5PFULLRCO2

976931
type: Reaction
notes: R_M4BTAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4BTAer equation: [r] : mem2emgacpail_hs + pre_prot --> gpi_sig + mem2emgacpail_prot_hs R_H8TAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H8TAer equation: [r] : gpi_hs + pre_prot --> gpi_prot_hs + gpi_sig R_M4ATAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_M4ATAer equation: [r] : m(em)3gacpail_hs + pre_prot --> gpi_sig + m(em)3gacpail_prot_hs R_H7_APOS_TAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_H7_APOS_TAer equation: [r] : em2emgacpail_hs + pre_prot --> em2emgacpail_prot_hs + gpi_sig
reactant: 428957
product: 429054
product: 429006
reactant: 428981
fast: false
is: ENSRNOG00000011366.4
product: 429018
reversible: false
reactant: 428969
reactant: 428945
reactant: 428993
is: ENSRNOG00000029280.1
is: ENSRNOG00000025181.3
product: 429042
product: 429030

428957
type: SpeciesReference
stoichiometry: 1.0
species: 315311

429054
type: SpeciesReference
stoichiometry: 1.0
species: 323854

323854
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ({[(mannosyl),(phosphoethanolaminyl)]-dimannosyl},{phosphoethanolaminyl})-mannosyl-glucosaminyl-acylphosphatidylinositol-Protein (M4B)_C59H110N3O40P3FULLRCO2FULLR2CO2X

429006
type: SpeciesReference
stoichiometry: 4.0
species: 318378

428981
type: SpeciesReference
stoichiometry: 1.0
species: 318354

429018
type: SpeciesReference
stoichiometry: 1.0
species: 318366

318366
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: glycophosphatidylinositol (GPI)-anchored protein_C55H106N4O38P4FULLRCO2FULLR2CO2X

428969
type: SpeciesReference
stoichiometry: 4.0
species: 327350

428945
type: SpeciesReference
stoichiometry: 1.0
species: 323515

428993
type: SpeciesReference
stoichiometry: 1.0
species: 323842

429042
type: SpeciesReference
stoichiometry: 1.0
species: 323527

429030
type: SpeciesReference
stoichiometry: 1.0
species: 315324

325598
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: _9-O-Acetylated GT3 (homo sapiens)_C65H106N4O37FULLRCO

317131
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: D-Glucosamine_C6H14NO5

974002
type: Reaction
notes: R_G13MT_L subsystem: N-Glycan Biosynthesis R_G13MT_L equation: [c] : gdpmann + (0.1) mpdol_L --> gdp + h + (0.1) m1mpdol_L R_G13MT_U subsystem: N-Glycan Biosynthesis R_G13MT_U equation: [c] : gdpmann + (0.1) mpdol_U --> gdp + h + (0.1) m1mpdol_U
product: 400155
product: 400131
is: ENSRNOG00000006369.4
product: 400143
fast: false
product: 400119
is: http://identifiers.org/ec-code/2.4.1.132
reactant: 400107
reactant: 400083
reversible: false
reactant: 400095

400155
type: SpeciesReference
stoichiometry: 1.0
species: 323143

323143
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: alpha-D-mannosyl-beta-D-mannosyl-diacylchitobiosyldiphosphodolichol, human uterine homolog_C1305H2140N20O270P20

400131
type: SpeciesReference
stoichiometry: 1.0
species: 323131

400143
type: SpeciesReference
stoichiometry: 2.0
species: 318954

400119
type: SpeciesReference
stoichiometry: 2.0
species: 317349

400107
type: SpeciesReference
stoichiometry: 1.0
species: 324423

324423
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: beta-D-Mannosyldiacetylchitobiosyldiphosphodolichol, human uterine homolog_C1245H2040N20O220P20

400083
type: SpeciesReference
stoichiometry: 2.0
species: 317446

317446
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: GDP-D-mannose_C16H23N5O16P2

400095
type: SpeciesReference
stoichiometry: 1.0
species: 324411

967748
type: Reaction
reactant: 340489
reactant: 340573
reactant: 340537
reversible: false
reactant: 340645
reactant: 340657
product: 340885
product: 340873
product: 340813
product: 340789
reactant: 340465
fast: false
product: 340801
product: 340777
product: 340729
reactant: 340501
product: 340717
product: 340705
reactant: 340585
reactant: 340621
reactant: 340549
reactant: 340477
reactant: 340561
product: 340765
reactant: 340513
reactant: 340525
product: 340753
reactant: 340669
product: 340741
product: 340861
reactant: 340597
product: 340849
reactant: 340633
is: ENSRNOG00000005687.4
product: 340837
reactant: 340609
product: 340825
product: 340693
notes: R_VALt4 subsystem: Transport, Extracellular R_VALt4 equation: na1[e] + val-L[e] --> na1[c] + val-L[c] R_THRt4 subsystem: Transport, Extracellular R_THRt4 equation: na1[e] + thr-L[e] --> na1[c] + thr-L[c] R_ILEt4 subsystem: Transport, Extracellular R_ILEt4 equation: ile-L[e] + na1[e] --> ile-L[c] + na1[c] R_METt4 subsystem: Transport, Extracellular R_METt4 equation: met-L[e] + na1[e] --> met-L[c] + na1[c] R_HISt4 subsystem: Transport, Extracellular R_HISt4 equation: his-L[e] + na1[e] --> his-L[c] + na1[c] R_LEUt4 subsystem: Transport, Extracellular R_LEUt4 equation: leu-L[e] + na1[e] --> leu-L[c] + na1[c] R_SERt4 subsystem: Transport, Extracellular R_SERt4 equation: na1[e] + ser-L[e] --> na1[c] + ser-L[c] R_ALAt4 subsystem: Transport, Extracellular R_ALAt4 equation: ala-L[e] + na1[e] --> ala-L[c] + na1[c] R_TYRt4 subsystem: Transport, Extracellular R_TYRt4 equation: na1[e] + tyr-L[e] --> na1[c] + tyr-L[c] R_CYSt4 subsystem: Transport, Extracellular R_CYSt4 equation: cys-L[e] + na1[e] --> cys-L[c] + na1[c] R_ARGt4 subsystem: Transport, Extracellular R_ARGt4 equation: arg-L[e] + na1[e] --> arg-L[c] + na1[c] R_ASNt4 subsystem: Transport, Extracellular R_ASNt4 equation: asn-L[e] + na1[e] --> asn-L[c] + na1[c] R_TRPt4 subsystem: Transport, Extracellular R_TRPt4 equation: na1[e] + trp-L[e] --> na1[c] + trp-L[c] R_GLYt4 subsystem: Transport, Extracellular R_GLYt4 equation: gly[e] + na1[e] --> gly[c] + na1[c] R_PHEt4 subsystem: Transport, Extracellular R_PHEt4 equation: na1[e] + phe-L[e] --> na1[c] + phe-L[c] R_GLNt4 subsystem: Transport, Extracellular R_GLNt4 equation: gln-L[e] + na1[e] --> gln-L[c] + na1[c] R_LYSt4 subsystem: Transport, Extracellular R_LYSt4 equation: lys-L[e] + na1[e] --> lys-L[c] + na1[c]
product: 340681

340489
type: SpeciesReference
stoichiometry: 1.0
species: 323095

340573
type: SpeciesReference
stoichiometry: 1.0
species: 309263

340537
type: SpeciesReference
stoichiometry: 1.0
species: 317630

340645
type: SpeciesReference
stoichiometry: 1.0
species: 331453

331453
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Valine_C5H11NO2

340657
type: SpeciesReference
stoichiometry: 17.0
species: 324628

340885
type: SpeciesReference
stoichiometry: 17.0
species: 324616

340873
type: SpeciesReference
stoichiometry: 1.0
species: 319446

340813
type: SpeciesReference
stoichiometry: 1.0
species: 309251

340789
type: SpeciesReference
stoichiometry: 1.0
species: 330186

340465
type: SpeciesReference
stoichiometry: 1.0
species: 309973

340801
type: SpeciesReference
stoichiometry: 1.0
species: 331441

340777
type: SpeciesReference
stoichiometry: 1.0
species: 322471

340729
type: SpeciesReference
stoichiometry: 1.0
species: 312918

340501
type: SpeciesReference
stoichiometry: 1.0
species: 330538

340717
type: SpeciesReference
stoichiometry: 1.0
species: 317871

340705
type: SpeciesReference
stoichiometry: 1.0
species: 323083

340585
type: SpeciesReference
stoichiometry: 1.0
species: 312930

340621
type: SpeciesReference
stoichiometry: 1.0
species: 323999

340549
type: SpeciesReference
stoichiometry: 1.0
species: 322483

340477
type: SpeciesReference
stoichiometry: 1.0
species: 317883

340561
type: SpeciesReference
stoichiometry: 1.0
species: 330778

340765
type: SpeciesReference
stoichiometry: 1.0
species: 323987

340513
type: SpeciesReference
stoichiometry: 1.0
species: 319458

340525
type: SpeciesReference
stoichiometry: 1.0
species: 330198

340753
type: SpeciesReference
stoichiometry: 1.0
species: 330766

340669
type: SpeciesReference
stoichiometry: 1.0
species: 320464

320464
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: L-Isoleucine_C6H13NO2

340741
type: SpeciesReference
stoichiometry: 1.0
species: 328773

340861
type: SpeciesReference
stoichiometry: 1.0
species: 330526

340597
type: SpeciesReference
stoichiometry: 1.0
species: 328785

340849
type: SpeciesReference
stoichiometry: 1.0
species: 326723

340633
type: SpeciesReference
stoichiometry: 1.0
species: 326735

340837
type: SpeciesReference
stoichiometry: 1.0
species: 317617

340609
type: SpeciesReference
stoichiometry: 1.0
species: 310046

340825
type: SpeciesReference
stoichiometry: 1.0
species: 320452

340693
type: SpeciesReference
stoichiometry: 1.0
species: 309961

340681
type: SpeciesReference
stoichiometry: 1.0
species: 310033

322651
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: lignocericyl coenzyme A_C45H78N7O17P3S

306847
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: heptaglutamyl folate (DHF)_C49H55N13O24

320247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Hypoxanthine_C5H4N4O

312675
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: chondroitin sulfate E (GalNAc4,6diS-GlcA), degradation product 7_C23H35O27S2

970011
type: Reaction
reactant: 360689
reversible: false
is: ENSRNOG00000007804.2
product: 360737
reactant: 360701
is: http://identifiers.org/ec-code/2.4.1.122
notes: R_N3Tg subsystem: O-Glycan Biosynthesis R_N3Tg equation: [g] : Tn_antigen + udpgal --> T_antigen + h + udp
fast: false
product: 360713
name: N-acetylgalactosamine 3-beta-galactosyltransferase, Golgi apparatus
product: 360725

360689
type: SpeciesReference
stoichiometry: 1.0
species: 331007

360737
type: SpeciesReference
stoichiometry: 1.0
species: 307548

307548
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: T antigen (core 1)_C14H24NO10X

360701
type: SpeciesReference
stoichiometry: 1.0
species: 307560

360713
type: SpeciesReference
stoichiometry: 1.0
species: 330850

360725
type: SpeciesReference
stoichiometry: 1.0
species: 318978

973317
type: Reaction
product: 391701
reactant: 391544
product: 391737
product: 391821
reactant: 391628
reactant: 391592
reactant: 391677
reactant: 391495
notes: R_3MOXTYROX subsystem: Tyrosine metabolism R_3MOXTYROX equation: [c] : 3moxtyr + h2o + o2 --> 3mox4hpac + h2o2 + nh4 R_MAOLNOR subsystem: Tyrosine metabolism R_MAOLNOR equation: [c] : h2o + normete-L + o2 --> 3m4hpga + h2o2 + nh4 R_APRTO2 subsystem: Arginine and Proline Metabolism R_APRTO2 equation: [c] : aprut + h2o + o2 --> h2o2 + n4abutn + nh4 R_42A12BOOX subsystem: Tyrosine metabolism R_42A12BOOX equation: [c] : dopa + h2o + o2 --> 34dhpac + h2o2 + nh4 R_PEAMNO subsystem: Phenylalanine metabolism R_PEAMNO equation: [c] : h2o + o2 + peamn --> h2o2 + nh4 + pacald R_MACOXO subsystem: Histidine Metabolism R_MACOXO equation: [c] : 3mldz + h2o + nad --> 3mlda + (2) h + nadh R_3HXKYNOXDA subsystem: Tryptophan metabolism R_3HXKYNOXDA equation: [c] : 3hxkynam + o2 --> 48dhoxquin + h2o2 + nh4 R_41R2A1H12BOOX subsystem: Tyrosine metabolism R_41R2A1H12BOOX equation: [c] : h2o + nrpphr + o2 --> 34dhmald + h2o2 + nh4 R_TRYPTAOX subsystem: Tryptophan metabolism R_TRYPTAOX equation: [c] : h2o + o2 + trypta --> h2o2 + id3acald + nh4 R_5HXKYNOXDA subsystem: Tryptophan metabolism R_5HXKYNOXDA equation: [c] : 5hxkynam + o2 --> 46dhoxquin + h2o2 + nh4 R_TYROXDAc subsystem: Tyrosine metabolism R_TYROXDAc equation: [c] : h2o + o2 + tym --> 4hoxpacd + h2o2 + nh4 R_5HOXINOXDA subsystem: Tryptophan metabolism R_5HOXINOXDA equation: [c] : h2o + o2 + srtn --> 5hoxindact + h2o2 + nh4 R_41R1H2MAE12BOOX subsystem: Tyrosine metabolism R_41R1H2MAE12BOOX equation: [c] : adrnl + h2o + o2 --> 34dhmald + h2o2 + mma
product: 391857
reactant: 391652
reversible: false
reactant: 391640
reactant: 391532
fast: false
product: 391785
product: 391713
reactant: 391508
product: 391761
reactant: 391580
product: 391881
product: 391749
product: 391833
reactant: 391616
is: http://identifiers.org/ec-code/1.4.3.6
product: 391869
product: 391725
reactant: 391604
reactant: 391520
is: http://identifiers.org/ec-code/1.2.1.5
product: 391797
reactant: 391664
is: ENSRNOG00000029778.2
product: 391773
reactant: 391568
is: http://identifiers.org/ec-code/1.4.3.4
product: 391689
reactant: 391556
product: 391809
product: 391845

391701
type: SpeciesReference
stoichiometry: 1.0
species: 324580

391544
type: SpeciesReference
stoichiometry: 1.0
species: 308863

391737
type: SpeciesReference
stoichiometry: 11.0
species: 324991

391821
type: SpeciesReference
stoichiometry: 1.0
species: 320356

391628
type: SpeciesReference
stoichiometry: 1.0
species: 305219

391592
type: SpeciesReference
stoichiometry: 1.0
species: 326590

391677
type: SpeciesReference
stoichiometry: 1.0
species: 309732

309732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetylputrescine_C6H15N2O

391495
type: SpeciesReference
stoichiometry: 1.0
species: 325247

391857
type: SpeciesReference
stoichiometry: 2.0
species: 304785

391652
type: SpeciesReference
stoichiometry: 11.0
species: 318846

391640
type: SpeciesReference
stoichiometry: 1.0
species: 314681

391532
type: SpeciesReference
stoichiometry: 1.0
species: 324676

391785
type: SpeciesReference
stoichiometry: 1.0
species: 306379

391713
type: SpeciesReference
stoichiometry: 1.0
species: 305825

391508
type: SpeciesReference
stoichiometry: 1.0
species: 305291

391761
type: SpeciesReference
stoichiometry: 1.0
species: 305279

391580
type: SpeciesReference
stoichiometry: 1.0
species: 305375

391881
type: SpeciesReference
stoichiometry: 1.0
species: 324749

391749
type: SpeciesReference
stoichiometry: 1.0
species: 324326

324326
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Methylamine_C1H6N

391833
type: SpeciesReference
stoichiometry: 1.0
species: 305641

305641
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4,8-Dihydroxyquinoline_C9H7NO2

391616
type: SpeciesReference
stoichiometry: 1.0
species: 329135

391869
type: SpeciesReference
stoichiometry: 1.0
species: 305629

391725
type: SpeciesReference
stoichiometry: 1.0
species: 304821

391604
type: SpeciesReference
stoichiometry: 1.0
species: 306475

391520
type: SpeciesReference
stoichiometry: 1.0
species: 325223

325223
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Normetanephrine_C9H14NO3

391797
type: SpeciesReference
stoichiometry: 1.0
species: 326070

391664
type: SpeciesReference
stoichiometry: 12.0
species: 325392

391773
type: SpeciesReference
stoichiometry: 1.0
species: 305243

391568
type: SpeciesReference
stoichiometry: 1.0
species: 330742

391689
type: SpeciesReference
stoichiometry: 1.0
species: 305363

391556
type: SpeciesReference
stoichiometry: 1.0
species: 330550

391809
type: SpeciesReference
stoichiometry: 12.0
species: 318774

391845
type: SpeciesReference
stoichiometry: 2.0
species: 318954

315504
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: estrone glucuronide_C24H30O8

304569
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _2-Decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone_C58H88O3

975899
type: Reaction
notes: R_GLYt7_LPAREN_311_RPAREN_r subsystem: Transport, Extracellular R_GLYt7_LPAREN_311_RPAREN_r equation: cl[e] + gly[e] + (3) na1[e] <==> cl[c] + gly[c] + (3) na1[c]
is: ENSRNOG00000031662.1
product: 417670
product: 417658
reactant: 417622
reactant: 417646
product: 417682
reversible: true
fast: false
reactant: 417634
name: glycine reversible transport via sodium and chloride symport (3:1:1)

417670
type: SpeciesReference
stoichiometry: 1.0
species: 311436

417658
type: SpeciesReference
stoichiometry: 1.0
species: 317871

417622
type: SpeciesReference
stoichiometry: 3.0
species: 324628

417646
type: SpeciesReference
stoichiometry: 1.0
species: 311448

417682
type: SpeciesReference
stoichiometry: 3.0
species: 324616

417634
type: SpeciesReference
stoichiometry: 1.0
species: 317883

976091
type: Reaction
reactant: 419585
notes: R_PPPGOm subsystem: Heme Biosynthesis R_PPPGOm equation: [m] : (3) o2 + (2) pppg9 --> (6) h2o + (2) ppp9
is: ENSRNOG00000003567.4
reversible: false
is: http://identifiers.org/ec-code/1.3.3.4
name: protoporphyrinogen oxidase, mitochondrial
fast: false
product: 419609
reactant: 419597
product: 419621

419585
type: SpeciesReference
stoichiometry: 2.0
species: 327290

419609
type: SpeciesReference
stoichiometry: 6.0
species: 318894

419597
type: SpeciesReference
stoichiometry: 3.0
species: 325416

419621
type: SpeciesReference
stoichiometry: 2.0
species: 327266

310480
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Biotinyl-5'-AMP_C20H27N7O9PS

970720
type: Reaction
product: 367069
product: 367081
fast: false
reactant: 366912
reactant: 366936
product: 367009
reactant: 366948
reactant: 366924
is: ENSRNOG00000016625.4
reversible: true
product: 367045
product: 367057
product: 367033
product: 367093
reactant: 366972
notes: R_CHOLtu subsystem: Transport, Extracellular R_CHOLtu equation: chol[e] <==> chol[c] R_PROSTGF2t subsystem: Transport, Extracellular R_PROSTGF2t equation: prostgf2[e] <==> prostgf2[c] R_NRPPHRtu subsystem: Transport, Extracellular R_NRPPHRtu equation: nrpphr[e] <==> nrpphr[c] R_DEBRISOQUINEt subsystem: Transport, Extracellular R_DEBRISOQUINEt equation: debrisoquine[e] <==> debrisoquine[c] R_SRTNtu subsystem: Transport, Extracellular R_SRTNtu equation: srtn[e] <==> srtn[c] R_PROSTGE2t2 subsystem: Transport, Extracellular R_PROSTGE2t2 equation: prostge2[e] <==> prostge2[c] R_DOPAtu subsystem: Transport, Extracellular R_DOPAtu equation: dopa[e] <==> dopa[c] R_HISTAtu subsystem: Transport, Extracellular R_HISTAtu equation: hista[e] <==> hista[c]
product: 367021
reactant: 366997
reactant: 366985
reactant: 366960

367069
type: SpeciesReference
stoichiometry: 1.0
species: 329135

367081
type: SpeciesReference
stoichiometry: 1.0
species: 319470

366912
type: SpeciesReference
stoichiometry: 1.0
species: 314693

366936
type: SpeciesReference
stoichiometry: 1.0
species: 329148

367009
type: SpeciesReference
stoichiometry: 1.0
species: 325247

366948
type: SpeciesReference
stoichiometry: 1.0
species: 319482

366924
type: SpeciesReference
stoichiometry: 1.0
species: 313583

313583
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: debrisoquine_C10H14N3

367045
type: SpeciesReference
stoichiometry: 1.0
species: 311036

367057
type: SpeciesReference
stoichiometry: 1.0
species: 327736

367033
type: SpeciesReference
stoichiometry: 1.0
species: 313571

313571
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: debrisoquine_C10H14N3

367093
type: SpeciesReference
stoichiometry: 1.0
species: 314681

366972
type: SpeciesReference
stoichiometry: 1.0
species: 325259

367021
type: SpeciesReference
stoichiometry: 1.0
species: 327700

366997
type: SpeciesReference
stoichiometry: 1.0
species: 327748

366985
type: SpeciesReference
stoichiometry: 1.0
species: 311048

366960
type: SpeciesReference
stoichiometry: 1.0
species: 327712

304869
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-(4-Hydroxyphenyl)pyruvate_C9H7O4

318136
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: glycogen, structure 4 (glycogenin-1,6-{2[1,4-Glc], [1,4-Glc]})_C18H31O16X

314717
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Dopamine 3-O-sulfate_C8H11NO5S

970590
type: Reaction
reactant: 366020
reactant: 366008
fast: false
is: ENSRNOG00000018964.2
product: 366068
product: 366056
reactant: 366032
product: 366080
product: 366044
name: glutathione synthetase
is: http://identifiers.org/ec-code/6.3.2.3
reversible: false
notes: R_GTHS subsystem: Glutathione Metabolism R_GTHS equation: [c] : atp + glucys + gly --> adp + gthrd + h + pi

366020
type: SpeciesReference
stoichiometry: 1.0
species: 310142

366008
type: SpeciesReference
stoichiometry: 1.0
species: 317871

366068
type: SpeciesReference
stoichiometry: 1.0
species: 318618

366056
type: SpeciesReference
stoichiometry: 1.0
species: 308621

366032
type: SpeciesReference
stoichiometry: 1.0
species: 317761

366080
type: SpeciesReference
stoichiometry: 1.0
species: 318954

366044
type: SpeciesReference
stoichiometry: 1.0
species: 326891

967002
type: Reaction
reactant: 333924
reversible: false
product: 333961
reactant: 333949
fast: false
product: 334009
reactant: 333900
product: 334033
reactant: 333912
is: http://identifiers.org/ec-code/3.6.1.6
product: 334021
reactant: 333937
reactant: 333888
product: 333997
notes: R_NTP3e subsystem: Nucleotides R_NTP3e equation: [e] : gtp + h2o --> gdp + h + pi R_NDP7ex subsystem: Nucleotides R_NDP7ex equation: [e] : h2o + udp --> h + pi + ump R_NDP10ex subsystem: Nucleotides R_NDP10ex equation: [e] : h2o + idp --> h + imp + pi R_NDP3ex subsystem: Nucleotides R_NDP3ex equation: [e] : gdp + h2o --> gmp + h + pi R_NDP8ex subsystem: Nucleotides R_NDP8ex equation: [e] : h2o + utp --> h + pi + udp
product: 333985
product: 333973
is: ENSRNOG00000003239.4
is: http://identifiers.org/ec-code/3.6.1.15

333924
type: SpeciesReference
stoichiometry: 1.0
species: 317361

317361
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: GDP_C10H12N5O11P2

333961
type: SpeciesReference
stoichiometry: 1.0
species: 318246

318246
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: GMP_C10H12N5O8P

333949
type: SpeciesReference
stoichiometry: 1.0
species: 318678

318678
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: GTP_C10H12N5O14P3

334009
type: SpeciesReference
stoichiometry: 5.0
species: 318966

333900
type: SpeciesReference
stoichiometry: 1.0
species: 330838

330838
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: UDP_C9H11N2O12P2

334033
type: SpeciesReference
stoichiometry: 1.0
species: 317361

333912
type: SpeciesReference
stoichiometry: 1.0
species: 320416

320416
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: IDP_C10H11N4O11P2

334021
type: SpeciesReference
stoichiometry: 5.0
species: 326903

333937
type: SpeciesReference
stoichiometry: 5.0
species: 318858

333888
type: SpeciesReference
stoichiometry: 1.0
species: 331344

333997
type: SpeciesReference
stoichiometry: 1.0
species: 331103

333985
type: SpeciesReference
stoichiometry: 1.0
species: 320548

333973
type: SpeciesReference
stoichiometry: 1.0
species: 330838

310360
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Bilirubin monoglucuronide_C39H44N4O12

328205
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: fatty acid retinol_C20H29OFULLR2CO

322543
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Leukotriene B4_C20H31O4

304196
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1,3-Diaminopropane_C3H12N2

967435
type: Reaction
product: 337857
product: 337833
notes: R_M16NTg subsystem: N-Glycan Biosynthesis R_M16NTg equation: [g] : nm2masn + uacgam --> h + n2m2masn + udp
product: 337845
reversible: false
fast: false
name: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
is: ENSRNOG00000012975.4
reactant: 337809
is: http://identifiers.org/ec-code/2.4.1.143
reactant: 337821

337857
type: SpeciesReference
stoichiometry: 1.0
species: 318978

337833
type: SpeciesReference
stoichiometry: 1.0
species: 324471

337845
type: SpeciesReference
stoichiometry: 1.0
species: 330850

337809
type: SpeciesReference
stoichiometry: 1.0
species: 325125

337821
type: SpeciesReference
stoichiometry: 1.0
species: 330814

308139
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: beta GalNAc globoside (homo sapiens)_C52H92N3O27FULLRCO

305062
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _3-Hydroxyanthranilate_C7H7NO3

324918
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Nicotinamide adenine dinucleotide phosphate - reduced_C21H26N7O17P3

331055
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: UDP-D-xylose_C14H20N2O16P2

976235
type: Reaction
reversible: false
notes: R_GLYOX subsystem: Pyruvate Metabolism R_GLYOX equation: [c] : h2o + lgt-S --> gthrd + h + lac-D
fast: false
is: http://identifiers.org/ec-code/3.1.2.6
product: 420382
reactant: 420345
product: 420357
name: hydroxyacylglutathione hydrolase
is: ENSRNOG00000019612.3
reactant: 420333
product: 420369

420382
type: SpeciesReference
stoichiometry: 1.0
species: 318954

420345
type: SpeciesReference
stoichiometry: 1.0
species: 318846

420357
type: SpeciesReference
stoichiometry: 1.0
species: 318618

420333
type: SpeciesReference
stoichiometry: 1.0
species: 322699

420369
type: SpeciesReference
stoichiometry: 1.0
species: 322287

967976
type: Reaction
reversible: true
reactant: 342367
product: 342415
is: ENSRNOG00000019651.3
product: 342391
product: 342403
reactant: 342355
is: ENSRNOG00000016372.4
fast: false
notes: R_KCC2t subsystem: Transport, Extracellular R_KCC2t equation: cl[e] + nh4[e] <==> cl[c] + nh4[c] R_KCCt subsystem: Transport, Extracellular R_KCCt equation: cl[e] + k[e] <==> cl[c] + k[c]
is: ENSRNOG00000005196.4
reactant: 342379

342367
type: SpeciesReference
stoichiometry: 1.0
species: 325004

342415
type: SpeciesReference
stoichiometry: 1.0
species: 324991

342391
type: SpeciesReference
stoichiometry: 1.0
species: 320764

342403
type: SpeciesReference
stoichiometry: 2.0
species: 311436

342355
type: SpeciesReference
stoichiometry: 1.0
species: 320776

342379
type: SpeciesReference
stoichiometry: 2.0
species: 311448

319662
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Hydroxypyruvate_C3H3O4

322939
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: gamma-linolenic acid_C18H29O2

329232
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: starch, structure 2 (1,6-{2[1,4-Glc], [1,4-Glc]})_C18H32O16

972273
type: Reaction
fast: false
reversible: false
product: 382153
name: cytochrome P450, family 7, subfamily A, polypeptide 1
product: 382177
is: http://identifiers.org/ec-code/1.14.13.17
product: 382165
is: ENSRNOG00000009488.2
reactant: 382104
reactant: 382116
notes: R_P4507A1r subsystem: Bile Acid Biosynthesis R_P4507A1r equation: [r] : chsterol + h + nadph + o2 --> h2o + nadp + xol7a
reactant: 382140
reactant: 382128

382153
type: SpeciesReference
stoichiometry: 1.0
species: 331646

331646
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _7 alpha-Hydroxycholesterol_C27H46O2

382177
type: SpeciesReference
stoichiometry: 1.0
species: 324845

382165
type: SpeciesReference
stoichiometry: 1.0
species: 318918

382104
type: SpeciesReference
stoichiometry: 1.0
species: 325440

382116
type: SpeciesReference
stoichiometry: 1.0
species: 311315

382140
type: SpeciesReference
stoichiometry: 1.0
species: 319026

382128
type: SpeciesReference
stoichiometry: 1.0
species: 324905

969831
type: Reaction
product: 359376
reactant: 359363
notes: R_PGI subsystem: Glycolysis/Gluconeogenesis R_PGI equation: [c] : g6p <==> f6p
is: ENSRNOG00000023150.2
is: http://identifiers.org/ec-code/5.3.1.9
fast: false
reversible: true
name: glucose-6-phosphate isomerase

359376
type: SpeciesReference
stoichiometry: 1.0
species: 315708

359363
type: SpeciesReference
stoichiometry: 1.0
species: 316720

305424
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _3-Oxooctadecanoyl-CoA_C39H64N7O18P3S

975947
type: Reaction
is: ENSRNOG00000029726.1
is: ENSRNOG00000019017.4
reactant: 417887
is: ENSRNOG00000018937.3
name: _13-cis-retinoic acid isomerase
is: ENSRNOG00000019094.3
fast: false
is: ENSRNOG00000019221.3
is: ENSRNOG00000029409.2
is: ENSRNOG00000019058.2
notes: R_RAI3 subsystem: Vitamin A Metabolism R_RAI3 equation: [c] : retn <==> 13-cis-retn
reversible: true
product: 417899

417887
type: SpeciesReference
stoichiometry: 1.0
species: 328315

417899
type: SpeciesReference
stoichiometry: 1.0
species: 304160

304160
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _13-cis-retinoate_C20H27O2

308669
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: ADP_C10H12N5O10P2

972237
type: Reaction
reactant: 381765
name: Propionyl-CoA carboxylase, mitochondrial
notes: R_PPCOACm subsystem: Valine, Leucine, and Isoleucine Metabolism R_PPCOACm equation: [m] : atp + hco3 + ppcoa --> adp + h + mmcoa-S + pi
product: 381789
reactant: 381777
product: 381813
is: ENSRNOG00000014146.4
reactant: 381753
product: 381825
fast: false
reversible: false
product: 381801
is: http://identifiers.org/ec-code/6.4.1.3

381765
type: SpeciesReference
stoichiometry: 1.0
species: 327133

381789
type: SpeciesReference
stoichiometry: 1.0
species: 324363

381777
type: SpeciesReference
stoichiometry: 1.0
species: 310166

381813
type: SpeciesReference
stoichiometry: 1.0
species: 308645

381753
type: SpeciesReference
stoichiometry: 1.0
species: 319134

381825
type: SpeciesReference
stoichiometry: 1.0
species: 319002

381801
type: SpeciesReference
stoichiometry: 1.0
species: 326939

971192
type: Reaction
reactant: 371248
reactant: 371261
fast: false
name: citrate transport via sodium symport
product: 371273
reversible: true
notes: R_CITt4_4 subsystem: Transport, Extracellular R_CITt4_4 equation: cit[e] + (4) na1[e] <==> cit[c] + (4) na1[c]
product: 371285
is: ENSRNOG00000014870.2
is: ENSRNOG00000010337.3

371248
type: SpeciesReference
stoichiometry: 4.0
species: 324628

371261
type: SpeciesReference
stoichiometry: 1.0
species: 311388

311388
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Citrate_C6H5O7

371273
type: SpeciesReference
stoichiometry: 4.0
species: 324616

371285
type: SpeciesReference
stoichiometry: 1.0
species: 311376

311376
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Citrate_C6H5O7

304088
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: _11-Deoxycorticosterone_C21H30O3

323712
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Maltotriose_C18H32O16

967327
type: Reaction
is: http://identifiers.org/ec-code/2.1.3.3
is: ENSRNOG00000003370.4
notes: R_OCBTm subsystem: Urea cycle/amino group metabolism R_OCBTm equation: [m] : cbp + orn --> citr-L + h + pi
name: ornithine carbamoyltransferase, irreversible
product: 336666
fast: false
reactant: 336642
product: 336654
reactant: 336630
reversible: false
product: 336678

336666
type: SpeciesReference
stoichiometry: 1.0
species: 311424

311424
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Citrulline_C6H13N3O3

336642
type: SpeciesReference
stoichiometry: 1.0
species: 310866

336654
type: SpeciesReference
stoichiometry: 1.0
species: 326939

336630
type: SpeciesReference
stoichiometry: 1.0
species: 325926

325926
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Ornithine_C5H13N2O2

336678
type: SpeciesReference
stoichiometry: 1.0
species: 319002

309154
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: _2-Oxoglutarate_C5H4O5

977135
type: Reaction
product: 431093
fast: false
reactant: 431045
is: ENSRNOG00000018282.4
is: http://identifiers.org/ec-code/3.5.4.3
reactant: 431057
reversible: false
notes: R_GUAD subsystem: Purine Catabolism R_GUAD equation: [c] : gua + h + h2o --> nh4 + xan
name: guanine deaminase
product: 431081
reactant: 431069

431093
type: SpeciesReference
stoichiometry: 1.0
species: 324991

431045
type: SpeciesReference
stoichiometry: 1.0
species: 318714

431057
type: SpeciesReference
stoichiometry: 1.0
species: 318846

431081
type: SpeciesReference
stoichiometry: 1.0
species: 331562

331562
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Xanthine_C5H4N4O2

431069
type: SpeciesReference
stoichiometry: 1.0
species: 318954

315420
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: estradiol glucuronide_C24H32O8

324640
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Sodium_Na

308247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Acetylcholine_C7H16NO2

325719
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: octadecadienoate (n-C18:2)_C18H31O2

975911
type: Reaction
product: 417766
reactant: 417730
reactant: 417694
reactant: 417718
product: 417778
is: ENSRNOG00000004601.3
is: ENSRNOG00000019470.4
product: 417754
notes: R_GLXO2p subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLXO2p equation: [x] : glx + h2o + o2 --> h + h2o2 + oxa R_GLYCTO1p subsystem: Glyoxylate and Dicarboxylate Metabolism R_GLYCTO1p equation: [x] : glyclt + o2 --> glx + h2o2
product: 417742
reactant: 417706
reversible: false
fast: false

417766
type: SpeciesReference
stoichiometry: 1.0
species: 325986

417730
type: SpeciesReference
stoichiometry: 1.0
species: 317859

317859
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303847
name: Glyoxylate_C2H1O3

417694
type: SpeciesReference
stoichiometry: 1.0
species: 318076

417718
type: SpeciesReference
stoichiometry: 2.0
species: 325452

417778
type: SpeciesReference
stoichiometry: 1.0
species: 319038

417754
type: SpeciesReference
stoichiometry: 1.0
species: 317859

417742
type: SpeciesReference
stoichiometry: 2.0
species: 318834

417706
type: SpeciesReference
stoichiometry: 1.0
species: 318930

974578
type: Reaction
reversible: false
name: NAD kinase
reactant: 406457
product: 406493
reactant: 406444
product: 406469
product: 406481
fast: false
notes: R_NADK subsystem: NAD Metabolism R_NADK equation: [c] : atp + nad --> adp + h + nadp
is: ENSRNOG00000016936.3
is: http://identifiers.org/ec-code/2.7.1.23

406457
type: SpeciesReference
stoichiometry: 1.0
species: 310142

406493
type: SpeciesReference
stoichiometry: 1.0
species: 318954

406444
type: SpeciesReference
stoichiometry: 1.0
species: 324676

406469
type: SpeciesReference
stoichiometry: 1.0
species: 308621

406481
type: SpeciesReference
stoichiometry: 1.0
species: 324797

970603
type: Reaction
is: http://identifiers.org/ec-code/2.7.1.17
fast: false
product: 366129
reactant: 366104
reactant: 366092
notes: R_XYLK subsystem: Pentose and Glucuronate Interconversions R_XYLK equation: [c] : atp + xylu-D --> adp + h + xu5p-D
name: xylulokinase
product: 366141
is: ENSRNOG00000014168.4
reversible: false
product: 366116

366129
type: SpeciesReference
stoichiometry: 1.0
species: 308621

366104
type: SpeciesReference
stoichiometry: 1.0
species: 310142

366092
type: SpeciesReference
stoichiometry: 1.0
species: 331998

331998
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: D-Xylulose_C5H10O5

366141
type: SpeciesReference
stoichiometry: 1.0
species: 318954

366116
type: SpeciesReference
stoichiometry: 1.0
species: 331950

331247
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: Urea_CH4N2O

321222
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate I, degradation product 40_C40H68N2O31

976403
type: Reaction
notes: R_CLI2tex subsystem: Transport, Extracellular R_CLI2tex equation: cl[e] + (2) i[c] --> cl[c] + (2) i[e] R_CLHCOtex subsystem: Transport, Extracellular R_CLHCOtex equation: cl[e] + (2) hco3[c] --> cl[c] + (2) hco3[e] R_CLFORtex subsystem: Transport, Extracellular R_CLFORtex equation: cl[e] + (2) for[c] --> cl[c] + (2) for[e]
product: 421698
fast: false
is: ENSRNOG00000007314.3
reactant: 421650
product: 421686
product: 421674
reactant: 421638
reactant: 421614
reactant: 421626
product: 421662
reversible: false

421698
type: SpeciesReference
stoichiometry: 2.0
species: 319122

421650
type: SpeciesReference
stoichiometry: 3.0
species: 311448

421686
type: SpeciesReference
stoichiometry: 2.0
species: 320295

421674
type: SpeciesReference
stoichiometry: 3.0
species: 311436

421638
type: SpeciesReference
stoichiometry: 2.0
species: 320283

320283
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Iodide_I

421614
type: SpeciesReference
stoichiometry: 2.0
species: 319110

421626
type: SpeciesReference
stoichiometry: 2.0
species: 316021

421662
type: SpeciesReference
stoichiometry: 2.0
species: 316033

976895
type: Reaction
reactant: 428593
reactant: 428581
product: 428642
product: 428629
reactant: 428569
reversible: false
product: 428654
product: 428605
is: ENSRNOG00000003650.3
is: http://identifiers.org/ec-code/3.1.3.5
reactant: 428557
reactant: 428545
fast: false
notes: R_NTD5 subsystem: Pyrimidine Catabolism R_NTD5 equation: [c] : dtmp + h2o --> pi + thymd R_NTD1 subsystem: Pyrimidine Catabolism R_NTD1 equation: [c] : dump + h2o --> duri + pi R_NTD3 subsystem: Pyrimidine Catabolism R_NTD3 equation: [c] : dcmp + h2o --> dcyt + pi R_NTD8 subsystem: Nucleotides R_NTD8 equation: [c] : dgmp + h2o --> dgsn + pi R_NTD12 subsystem: Nucleotides R_NTD12 equation: [c] : dimp + h2o --> din + pi
product: 428666
product: 428617
reactant: 428533

428593
type: SpeciesReference
stoichiometry: 1.0
species: 313303

428581
type: SpeciesReference
stoichiometry: 5.0
species: 318846

428642
type: SpeciesReference
stoichiometry: 1.0
species: 330234

428629
type: SpeciesReference
stoichiometry: 5.0
species: 326891

428569
type: SpeciesReference
stoichiometry: 1.0
species: 314850

314850
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dTMP_C10H13N2O8P

428654
type: SpeciesReference
stoichiometry: 1.0
species: 313449

428605
type: SpeciesReference
stoichiometry: 1.0
species: 315022

428557
type: SpeciesReference
stoichiometry: 1.0
species: 314986

314986
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: dUMP_C9H11N2O8P

428545
type: SpeciesReference
stoichiometry: 1.0
species: 314199

428666
type: SpeciesReference
stoichiometry: 1.0
species: 313728

428617
type: SpeciesReference
stoichiometry: 1.0
species: 314211

428533
type: SpeciesReference
stoichiometry: 1.0
species: 313679

319626
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: heptadecanoyl coa_C38H64N7O17P3S

310287
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Betaine aldehyde_C5H12NO

971528
type: Reaction
product: 373878
notes: R_FUCASEly subsystem: N-Glycan Degradation R_FUCASEly equation: [l] : h2o + s2l2fn2m2masn --> fuc-L + s2l2n2m2masn R_FUCASE2ly subsystem: Keratan sulfate degradation R_FUCASE2ly equation: [l] : h2o + ksi --> fuc-L + ksi_deg1
reversible: false
is: ENSRNOG00000009325.4
reactant: 373854
product: 373890
reactant: 373842
reactant: 373866
product: 373902
fast: false
is: http://identifiers.org/ec-code/3.2.1.51

373878
type: SpeciesReference
stoichiometry: 1.0
species: 328472

373854
type: SpeciesReference
stoichiometry: 2.0
species: 318882

373890
type: SpeciesReference
stoichiometry: 2.0
species: 316274

373842
type: SpeciesReference
stoichiometry: 1.0
species: 321346

373866
type: SpeciesReference
stoichiometry: 1.0
species: 328424

328424
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: PA6_C90H145N6O65X

373902
type: SpeciesReference
stoichiometry: 1.0
species: 320945

967194
type: Reaction
is: ENSRNOG00000039300.1
is: http://identifiers.org/ec-code/3.3.1.1
name: Se-Adenosylselenohomocysteine hydrolase
is: ENSRNOG00000013206.3
product: 335732
product: 335744
is: ENSRNOG00000025827.2
notes: R_SEAHCYSHYD subsystem: Selenoamino acid metabolism R_SEAHCYSHYD equation: [c] : h2o + seahcys --> adn + selhcys
reversible: false
fast: false
reactant: 335720
reactant: 335708

335732
type: SpeciesReference
stoichiometry: 1.0
species: 328701

335744
type: SpeciesReference
stoichiometry: 1.0
species: 308561

335720
type: SpeciesReference
stoichiometry: 1.0
species: 318846

335708
type: SpeciesReference
stoichiometry: 1.0
species: 328604

329776
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: tetracosapentaenoic acid, n-6_C24H37O2

969323
type: Reaction
product: 355141
reversible: false
notes: R_PGL subsystem: Pentose Phosphate Pathway R_PGL equation: [c] : 6pgl + h2o --> 6pgc + h
is: ENSRNOG00000018326.4
fast: false
reactant: 355129
name: _6-phosphogluconolactonase
is: http://identifiers.org/ec-code/3.1.1.31
reactant: 355117
product: 355153

355141
type: SpeciesReference
stoichiometry: 1.0
species: 306691

306691
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _6-Phospho-D-gluconate_C6H10O10P

355129
type: SpeciesReference
stoichiometry: 1.0
species: 306715

355117
type: SpeciesReference
stoichiometry: 1.0
species: 318846

355153
type: SpeciesReference
stoichiometry: 1.0
species: 318954

975155
type: Reaction
fast: false
notes: R_G3PD2m subsystem: Glycolysis/Gluconeogenesis R_G3PD2m equation: fad[m] + glyc3p[c] --> dhap[c] + fadh2[m]
is: ENSRNOG00000033824.1
reactant: 410928
product: 410952
product: 410940
reversible: false
is: http://identifiers.org/ec-code/1.1.99.5
reactant: 410916
name: glycerol-3-phosphate dehydrogenase (FAD), mitochondrial

410928
type: SpeciesReference
stoichiometry: 1.0
species: 315732

410952
type: SpeciesReference
stoichiometry: 1.0
species: 313812

410940
type: SpeciesReference
stoichiometry: 1.0
species: 315780

410916
type: SpeciesReference
stoichiometry: 1.0
species: 317967

306185
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _5alpha-Dihydrotestosterone glucuronide_C25H38O8

975071
type: Reaction
reactant: 410386
product: 410435
is: http://identifiers.org/ec-code/4.4.1.1
fast: false
product: 410411
product: 410447
reactant: 410399
notes: R_SELCYSTGL subsystem: Selenoamino acid metabolism R_SELCYSTGL equation: [c] : h2o + selcyst --> 2obut + nh4 + selcys R_CYSTGL subsystem: Cysteine Metabolism R_CYSTGL equation: [c] : cyst-L + h2o --> 2obut + cys-L + nh4
product: 410423
is: ENSRNOG00000010658.3
reactant: 410374
reversible: false

410386
type: SpeciesReference
stoichiometry: 1.0
species: 328689

410435
type: SpeciesReference
stoichiometry: 1.0
species: 328677

410411
type: SpeciesReference
stoichiometry: 1.0
species: 312918

410447
type: SpeciesReference
stoichiometry: 2.0
species: 324991

410399
type: SpeciesReference
stoichiometry: 2.0
species: 318846

410423
type: SpeciesReference
stoichiometry: 2.0
species: 304713

410374
type: SpeciesReference
stoichiometry: 1.0
species: 312966

304965
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-3-Amino-isobutanoate_C4H9NO2

969071
type: Reaction
notes: R_GLUCYS subsystem: Glutathione Metabolism R_GLUCYS equation: [c] : atp + cys-L + glu-L --> adp + glucys + h + pi
product: 352759
fast: false
reactant: 352735
reversible: false
product: 352783
product: 352771
is: ENSRNOG00000013409.3
reactant: 352747
is: http://identifiers.org/ec-code/6.3.2.2
is: ENSRNOG00000006302.3
product: 352795
reactant: 352723
name: gamma-glutamylcysteine synthetase

352759
type: SpeciesReference
stoichiometry: 1.0
species: 326891

352735
type: SpeciesReference
stoichiometry: 1.0
species: 310142

352783
type: SpeciesReference
stoichiometry: 1.0
species: 308621

352771
type: SpeciesReference
stoichiometry: 1.0
species: 317761

352747
type: SpeciesReference
stoichiometry: 1.0
species: 317683

352795
type: SpeciesReference
stoichiometry: 1.0
species: 318954

352723
type: SpeciesReference
stoichiometry: 1.0
species: 312918

974014
type: Reaction
product: 400239
is: http://identifiers.org/ec-code/1.14.15.4
fast: false
is: ENSRNOG00000030111.1
reactant: 400179
reactant: 400167
product: 400263
is: ENSRNOG00000006598.4
is: ENSRNOG00000032450.2
notes: R_P45011B11m subsystem: Steroid Metabolism R_P45011B11m equation: [m] : 11docrtstrn + h + nadph + o2 --> crtstrn + h2o + nadp R_P45011B12m subsystem: Steroid Metabolism R_P45011B12m equation: [m] : 11docrtsl + h + nadph + o2 --> crtsl + h2o + nadp
product: 400227
reactant: 400215
is: ENSRNOG00000037385.1
reactant: 400203
reversible: false
product: 400251
reactant: 400191

400239
type: SpeciesReference
stoichiometry: 2.0
species: 318894

400179
type: SpeciesReference
stoichiometry: 1.0
species: 304052

400167
type: SpeciesReference
stoichiometry: 1.0
species: 304076

304076
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _11-Deoxycorticosterone_C21H30O3

400263
type: SpeciesReference
stoichiometry: 2.0
species: 324821

400227
type: SpeciesReference
stoichiometry: 1.0
species: 312110

312110
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Cortisol_C21H30O5

400215
type: SpeciesReference
stoichiometry: 2.0
species: 319002

400203
type: SpeciesReference
stoichiometry: 2.0
species: 325416

400251
type: SpeciesReference
stoichiometry: 1.0
species: 312134

312134
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Corticosterone_C21H30O4

400191
type: SpeciesReference
stoichiometry: 2.0
species: 324881

968205
type: Reaction
name: phosphatidate cytidylyltransferase
product: 344855
is: http://identifiers.org/ec-code/2.7.7.41
fast: false
reactant: 344819
notes: R_CDS subsystem: Glycerophospholipid Metabolism R_CDS equation: [c] : ctp + h + pa_hs --> cdpdag_hs + ppi
is: ENSRNOG00000002142.3
reversible: false
product: 344843
reactant: 344831
reactant: 344807

344855
type: SpeciesReference
stoichiometry: 1.0
species: 327157

344819
type: SpeciesReference
stoichiometry: 1.0
species: 318954

344843
type: SpeciesReference
stoichiometry: 1.0
species: 310939

344831
type: SpeciesReference
stoichiometry: 1.0
species: 312857

344807
type: SpeciesReference
stoichiometry: 1.0
species: 325998

315588
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Electron transfer flavoprotein reduced_RH2

968638
type: Reaction
notes: R_SO4HCOtex subsystem: Transport, Extracellular R_SO4HCOtex equation: (2) hco3[c] + so4[e] --> (2) hco3[e] + so4[c]
reactant: 349079
reactant: 349067
product: 349091
is: ENSRNOG00000030537.2
name: sulfate transport via bicarbonate countertransport
product: 349103
fast: false
reversible: false

349079
type: SpeciesReference
stoichiometry: 1.0
species: 328905

349067
type: SpeciesReference
stoichiometry: 2.0
species: 319110

349091
type: SpeciesReference
stoichiometry: 1.0
species: 328893

349103
type: SpeciesReference
stoichiometry: 2.0
species: 319122

316732
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: D-Glucose 6-phosphate_C6H11O9P

323902
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: Methanol_CH4O1

972465
type: Reaction
is: ENSRNOG00000030862.2
is: ENSRNOG00000036814.1
is: ENSRNOG00000000840.3
is: ENSRNOG00000004846.4
is: ENSRNOG00000001019.4
reactant: 384990
is: ENSRNOG00000015566.4
is: http://identifiers.org/ec-code/3.6.3.14
name: V-type ATPase, H+ transporting, lysosomal
product: 385051
product: 385039
notes: R_ATPasel subsystem: Transport, Lysosomal R_ATPasel equation: atp[c] + (3) h[c] + h2o[c] --> adp[c] + (4) h[l] + pi[c]
is: ENSRNOG00000016805.4
is: ENSRNOG00000011905.3
is: ENSRNOG00000007392.2
product: 385027
is: ENSRNOG00000019655.4
is: ENSRNOG00000017235.4
reversible: false
is: ENSRNOG00000025562.2
reactant: 385014
is: ENSRNOG00000006926.4
is: ENSRNOG00000013428.3
is: ENSRNOG00000011891.4
is: ENSRNOG00000009080.3
is: ENSRNOG00000008163.4
is: ENSRNOG00000017220.4
is: ENSRNOG00000022480.3
is: ENSRNOG00000013573.4
reactant: 385002
is: ENSRNOG00000001992.4
is: ENSRNOG00000038969.1
is: ENSRNOG00000006542.3
fast: false

384990
type: SpeciesReference
stoichiometry: 1.0
species: 310142

385051
type: SpeciesReference
stoichiometry: 1.0
species: 308621

385039
type: SpeciesReference
stoichiometry: 4.0
species: 318990

385027
type: SpeciesReference
stoichiometry: 1.0
species: 326891

385014
type: SpeciesReference
stoichiometry: 3.0
species: 318954

385002
type: SpeciesReference
stoichiometry: 1.0
species: 318846

977363
type: Reaction
reactant: 432604
reactant: 432578
reactant: 432654
reversible: false
is: ENSRNOG00000005248.3
product: 432719
reactant: 432617
reactant: 432680
reactant: 432667
fast: false
reactant: 432641
product: 432732
notes: R_CYSTHRNaEx subsystem: Transport, Extracellular R_CYSTHRNaEx equation: cys-L[e] + na1[e] + thr-L[c] --> cys-L[c] + na1[c] + thr-L[e] R_THRSERNaEx subsystem: Transport, Extracellular R_THRSERNaEx equation: na1[e] + ser-L[c] + thr-L[e] --> na1[c] + ser-L[e] + thr-L[c] R_ALACYSNaEx subsystem: Transport, Extracellular R_ALACYSNaEx equation: ala-L[e] + cys-L[c] + na1[e] --> ala-L[c] + cys-L[e] + na1[c] R_THRALANaEx subsystem: Transport, Extracellular R_THRALANaEx equation: ala-L[c] + na1[e] + thr-L[e] --> ala-L[e] + na1[c] + thr-L[c] R_CYSALANaEx subsystem: Transport, Extracellular R_CYSALANaEx equation: ala-L[c] + cys-L[e] + na1[e] --> ala-L[e] + cys-L[c] + na1[c] R_SERTHRNaEx subsystem: Transport, Extracellular R_SERTHRNaEx equation: na1[e] + ser-L[e] + thr-L[c] --> na1[c] + ser-L[c] + thr-L[e] R_SERCYSNaEx subsystem: Transport, Extracellular R_SERCYSNaEx equation: cys-L[c] + na1[e] + ser-L[e] --> cys-L[e] + na1[c] + ser-L[c] R_ALASERNaEx subsystem: Transport, Extracellular R_ALASERNaEx equation: ala-L[e] + na1[e] + ser-L[c] --> ala-L[c] + na1[c] + ser-L[e] R_SERALANaEx subsystem: Transport, Extracellular R_SERALANaEx equation: ala-L[c] + na1[e] + ser-L[e] --> ala-L[e] + na1[c] + ser-L[c] R_ALATHRNaEx subsystem: Transport, Extracellular R_ALATHRNaEx equation: ala-L[e] + na1[e] + thr-L[c] --> ala-L[c] + na1[c] + thr-L[e] R_THRCYSNaEx subsystem: Transport, Extracellular R_THRCYSNaEx equation: cys-L[c] + na1[e] + thr-L[e] --> cys-L[e] + na1[c] + thr-L[c] R_CYSSERNaEx subsystem: Transport, Extracellular R_CYSSERNaEx equation: cys-L[e] + na1[e] + ser-L[c] --> cys-L[c] + na1[c] + ser-L[e]
product: 432794
reactant: 432591
product: 432782
product: 432706
reactant: 432629
product: 432758
product: 432693
product: 432745
product: 432770

432604
type: SpeciesReference
stoichiometry: 3.0
species: 309263

432578
type: SpeciesReference
stoichiometry: 3.0
species: 312918

432654
type: SpeciesReference
stoichiometry: 3.0
species: 330186

432719
type: SpeciesReference
stoichiometry: 3.0
species: 309263

432617
type: SpeciesReference
stoichiometry: 3.0
species: 312930

432680
type: SpeciesReference
stoichiometry: 3.0
species: 309251

432667
type: SpeciesReference
stoichiometry: 3.0
species: 328785

432641
type: SpeciesReference
stoichiometry: 3.0
species: 330198

432732
type: SpeciesReference
stoichiometry: 3.0
species: 312930

432794
type: SpeciesReference
stoichiometry: 3.0
species: 328785

432591
type: SpeciesReference
stoichiometry: 3.0
species: 328773

432782
type: SpeciesReference
stoichiometry: 3.0
species: 309251

432706
type: SpeciesReference
stoichiometry: 3.0
species: 312918

432629
type: SpeciesReference
stoichiometry: 12.0
species: 324628

432758
type: SpeciesReference
stoichiometry: 3.0
species: 330198

432693
type: SpeciesReference
stoichiometry: 3.0
species: 328773

432745
type: SpeciesReference
stoichiometry: 12.0
species: 324616

432770
type: SpeciesReference
stoichiometry: 3.0
species: 330186

309058
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-amino-1-(5-phospho-D-ribosyl)imidazole_C8H12N3O7P

307669
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetyl-ACP_C13H23N2O8PRS

970337
type: Reaction
reactant: 363476
fast: false
product: 363524
reversible: false
product: 363536
notes: R_DOPASULT subsystem: Tyrosine metabolism R_DOPASULT equation: [c] : dopa + paps --> dopasf + h + pap R_4NPHSULT subsystem: CYP Metabolism R_4NPHSULT equation: [c] : 4nph + paps --> 4nphsf + h + pap
is: ENSRNOG00000001960.4
is: http://identifiers.org/ec-code/2.8.2.1
product: 363512
is: ENSRNOG00000040195.1
is: ENSRNOG00000001967.2
reactant: 363500
product: 363548
reactant: 363488
is: ENSRNOG00000031833.2

363476
type: SpeciesReference
stoichiometry: 2.0
species: 326373

363524
type: SpeciesReference
stoichiometry: 1.0
species: 314717

363536
type: SpeciesReference
stoichiometry: 1.0
species: 305991

305991
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Nitrophenyl sulfate_C6H4NO6S

363512
type: SpeciesReference
stoichiometry: 2.0
species: 326349

363500
type: SpeciesReference
stoichiometry: 1.0
species: 314681

363548
type: SpeciesReference
stoichiometry: 2.0
species: 318954

363488
type: SpeciesReference
stoichiometry: 1.0
species: 305979

305979
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _4-Nitrophenol_C6H5NO3

307897
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Acetol_C3H6O2

313838
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _6,7-Dihydrobiopterin_C9H13N5O3

975323
type: Reaction
modifier: 412797
product: 412761
is: ENSRNOG00000011535.4
modifier: 412859
product: 412773
modifier: 412896
is: http://identifiers.org/ec-code/2.1.2.10
is: http://identifiers.org/ec-code/1.4.4.2
modifier: 412909
notes: R_GCCbim subsystem: Glycine, Serine, and Threonine Metabolism R_GCCbim equation: [m] : alpro + thf --> dhlpro + mlthf + nh4 R_GCCcm subsystem: Glycine, Serine, and Threonine Metabolism R_GCCcm equation: [m] : dhlpro + nad <==> h + lpro + nadh R_GCC2bim subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2bim equation: [m] : alpam + thf --> dhlam + mlthf + nh4 R_GCCam subsystem: Glycine, Serine, and Threonine Metabolism R_GCCam equation: [m] : gly + h + lpro <==> alpro + co2 R_GCC2cm subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2cm equation: [m] : dhlam + nad <==> h + lpam + nadh R_GCC2am subsystem: Glycine, Serine, and Threonine Metabolism R_GCC2am equation: [m] : gly + h + lpam <==> alpam + co2
product: 412749
is: http://identifiers.org/ec-code/1.8.1.4
reversible: false
modifier: 412884
fast: false
is: ENSRNOG00000002881.4
reactant: 412713
modifier: 412821
is: ENSRNOG00000011941.2
modifier: 412871
modifier: 412785
reactant: 412701
product: 412737
modifier: 412809
modifier: 412834
modifier: 412846
reactant: 412725

412761
type: SpeciesReference
stoichiometry: 1.0
species: 314078

314078
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Dihydrolipoamide_C8H17NOS2

412773
type: SpeciesReference
stoichiometry: 2.0
species: 324314

412749
type: SpeciesReference
stoichiometry: 2.0
species: 325016

412713
type: SpeciesReference
stoichiometry: 1.0
species: 309371

309371
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: S-Aminomethyldihydrolipoylprotein_CH6NS2X

323011
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Lipoamide_C8H15NOS2

412701
type: SpeciesReference
stoichiometry: 1.0
species: 309359

412737
type: SpeciesReference
stoichiometry: 1.0
species: 314090

314090
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: Dihydrolipolprotein_H2S2X

412725
type: SpeciesReference
stoichiometry: 2.0
species: 330077

329050
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: sphingomyelin (homo sapiens)_C23H48N2O5PFULLRCO

967014
type: Reaction
product: 334057
reactant: 334045
notes: R_CHSTEROLt1 subsystem: Transport, Mitochondrial R_CHSTEROLt1 equation: chsterol[l] <==> chsterol[m]
is: ENSRNOG00000028387.3
fast: false
reversible: true
name: cholesterol intracellular transport

334057
type: SpeciesReference
stoichiometry: 1.0
species: 311303

334045
type: SpeciesReference
stoichiometry: 1.0
species: 311291

311291
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: Cholesterol_C27H46O

303943
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: _10-formyltetrahydrofolate-[Glu](6)_C45H51N12O22

305037
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823

327591
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: L-Proline_C5H9NO2

974674
type: Reaction
product: 407372
is: ENSRNOG00000011071.3
product: 407360
is: http://identifiers.org/ec-code/3.1.3.5
reversible: false
product: 407384
reactant: 407272
reactant: 407311
notes: R_NTD7e subsystem: Nucleotides R_NTD7e equation: [e] : amp + h2o --> adn + pi R_NTD2e subsystem: Nucleotides R_NTD2e equation: [e] : h2o + ump --> pi + uri R_NTD9e subsystem: Nucleotides R_NTD9e equation: [e] : gmp + h2o --> gsn + pi R_NTD4e subsystem: Nucleotides R_NTD4e equation: [e] : cmp + h2o --> cytd + pi
reactant: 407286
product: 407348
reactant: 407299
product: 407335
reactant: 407323
fast: false

407372
type: SpeciesReference
stoichiometry: 1.0
species: 308573

407360
type: SpeciesReference
stoichiometry: 1.0
species: 312990

407384
type: SpeciesReference
stoichiometry: 1.0
species: 318462

407272
type: SpeciesReference
stoichiometry: 1.0
species: 318246

407311
type: SpeciesReference
stoichiometry: 4.0
species: 318858

407286
type: SpeciesReference
stoichiometry: 1.0
species: 311570

407348
type: SpeciesReference
stoichiometry: 4.0
species: 326903

407299
type: SpeciesReference
stoichiometry: 1.0
species: 309467

407335
type: SpeciesReference
stoichiometry: 1.0
species: 331284

407323
type: SpeciesReference
stoichiometry: 1.0
species: 331103

308344
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetylneuraminate_C11H18NO9

968806
type: Reaction
product: 350623
reactant: 350611
notes: R_ACGAMPM subsystem: Aminosugar Metabolism R_ACGAMPM equation: [c] : acgam6p <==> acgam1p
is: ENSRNOG00000009515.4
is: http://identifiers.org/ec-code/5.4.2.3
fast: false
reversible: true
name: phosphoacetylglucosamine mutase

350623
type: SpeciesReference
stoichiometry: 1.0
species: 308079

350611
type: SpeciesReference
stoichiometry: 1.0
species: 308091

308091
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: N-Acetyl-D-glucosamine 6-phosphate_C8H14NO9P

970447
type: Reaction
product: 364126
reactant: 364090
reactant: 364078
is: http://identifiers.org/ec-code/1.3.99.3
fast: false
notes: R_PPCOAOm subsystem: Propanoate Metabolism R_PPCOAOm equation: [m] : fad + ppcoa --> fadh2 + prpncoa R_ACOAD1fm subsystem: Butanoate Metabolism R_ACOAD1fm equation: [m] : btcoa + fad --> b2coa + fadh2
reactant: 364066
is: http://identifiers.org/ec-code/1.3.99.2
product: 364102
is: ENSRNOG00000014178.3
product: 364114
is: ENSRNOG00000010940.4
reversible: false

364126
type: SpeciesReference
stoichiometry: 1.0
species: 310215

364090
type: SpeciesReference
stoichiometry: 2.0
species: 315732

364078
type: SpeciesReference
stoichiometry: 1.0
species: 327133

364066
type: SpeciesReference
stoichiometry: 1.0
species: 310504

364102
type: SpeciesReference
stoichiometry: 2.0
species: 315780

364114
type: SpeciesReference
stoichiometry: 1.0
species: 327796

975383
type: Reaction
product: 413354
reactant: 413330
reactant: 413294
product: 413366
fast: false
notes: R_METtec subsystem: Transport, Extracellular R_METtec equation: met-L[e] <==> met-L[c] R_ILEtec subsystem: Transport, Extracellular R_ILEtec equation: ile-L[e] <==> ile-L[c] R_CYStec subsystem: Transport, Extracellular R_CYStec equation: cys-L[e] <==> cys-L[c] R_LEUtec subsystem: Transport, Extracellular R_LEUtec equation: leu-L[e] <==> leu-L[c] R_VALtec subsystem: Transport, Extracellular R_VALtec equation: val-L[e] <==> val-L[c] R_PHEtec subsystem: Transport, Extracellular R_PHEtec equation: phe-L[e] <==> phe-L[c]
product: 413378
reactant: 413282
product: 413391
product: 413403
reactant: 413318
reversible: true
product: 413342
is: ENSRNOG00000003835.3
reactant: 413306
reactant: 413270

413354
type: SpeciesReference
stoichiometry: 1.0
species: 331441

413330
type: SpeciesReference
stoichiometry: 1.0
species: 326735

413294
type: SpeciesReference
stoichiometry: 1.0
species: 323999

413366
type: SpeciesReference
stoichiometry: 1.0
species: 320452

413378
type: SpeciesReference
stoichiometry: 1.0
species: 323987

413282
type: SpeciesReference
stoichiometry: 1.0
species: 312930

413391
type: SpeciesReference
stoichiometry: 1.0
species: 322471

413403
type: SpeciesReference
stoichiometry: 1.0
species: 326723

413318
type: SpeciesReference
stoichiometry: 1.0
species: 320464

413342
type: SpeciesReference
stoichiometry: 1.0
species: 312918

413306
type: SpeciesReference
stoichiometry: 1.0
species: 331453

413270
type: SpeciesReference
stoichiometry: 1.0
species: 322483

972633
type: Reaction
name: IMP dehydrogenase
product: 386378
is: ENSRNOG00000031965.1
product: 386402
fast: false
reactant: 386354
notes: R_IMPD subsystem: Nucleotides R_IMPD equation: [c] : h2o + imp + nad --> h + nadh + xmp
reactant: 386342
reactant: 386366
is: http://identifiers.org/ec-code/1.1.1.205
product: 386390
reversible: false

386378
type: SpeciesReference
stoichiometry: 1.0
species: 331586

386402
type: SpeciesReference
stoichiometry: 1.0
species: 324749

386354
type: SpeciesReference
stoichiometry: 1.0
species: 320536

386342
type: SpeciesReference
stoichiometry: 1.0
species: 324676

386366
type: SpeciesReference
stoichiometry: 1.0
species: 318846

386390
type: SpeciesReference
stoichiometry: 1.0
species: 318954

969599
type: Reaction
fast: false
reactant: 356961
reversible: true
product: 356985
reactant: 356949
product: 356973
is: ENSRNOG00000011361.3
notes: R_PIter subsystem: Transport, Endoplasmic Reticular R_PIter equation: pi[r] <==> pi[c] R_G6Pter subsystem: Transport, Endoplasmic Reticular R_G6Pter equation: g6p[c] <==> g6p[r]

356961
type: SpeciesReference
stoichiometry: 1.0
species: 316720

356985
type: SpeciesReference
stoichiometry: 1.0
species: 316732

356949
type: SpeciesReference
stoichiometry: 1.0
species: 326963

356973
type: SpeciesReference
stoichiometry: 1.0
species: 326891

320440
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: IDP_C10H11N4O11P2

973125
type: Reaction
reactant: 389950
product: 389998
notes: R_NDP7g subsystem: Nucleotides R_NDP7g equation: [g] : h2o + udp --> h + pi + ump
name: nucleoside-diphosphatase (UDP), Golgi apparatus
reversible: false
product: 389986
fast: false
is: ENSRNOG00000016321.4
is: http://identifiers.org/ec-code/3.6.1.6
reactant: 389962
product: 389974

389950
type: SpeciesReference
stoichiometry: 1.0
species: 330850

389998
type: SpeciesReference
stoichiometry: 1.0
species: 331115

331115
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: UMP_C9H11N2O9P

389986
type: SpeciesReference
stoichiometry: 1.0
species: 326915

326915
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Phosphate_HO4P

389962
type: SpeciesReference
stoichiometry: 1.0
species: 318870

389974
type: SpeciesReference
stoichiometry: 1.0
species: 318978

330874
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: UDP_C9H11N2O12P2

309756
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Arabinose_C5H10O5

970252
type: Reaction
reactant: 362574
is: ENSRNOG00000019932.3
product: 362695
reactant: 362634
reversible: false
product: 362658
product: 362719
fast: false
product: 362731
reactant: 362622
product: 362683
product: 362671
reactant: 362598
product: 362646
product: 362707
notes: R_PMI1346PHn subsystem: Inositol Phosphate Metabolism R_PMI1346PHn equation: [n] : h2o + ppmi1346p --> h + mi13456p + pi R_PMI1346PH subsystem: Inositol Phosphate Metabolism R_PMI1346PH equation: [c] : h2o + ppmi1346p --> h + mi13456p + pi R_PMI12346PHn subsystem: Inositol Phosphate Metabolism R_PMI12346PHn equation: [n] : h2o + ppmi12346p --> h + minohp + pi R_PMI12346PH subsystem: Inositol Phosphate Metabolism R_PMI12346PH equation: [c] : h2o + ppmi12346p --> h + minohp + pi
is: http://identifiers.org/ec-code/3.6.1.52
reactant: 362586
reactant: 362610
is: ENSRNOG00000025883.2

362574
type: SpeciesReference
stoichiometry: 1.0
species: 327218

327218
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _5-Diphosphoinositol pentakisphosphate_C6H6O27P7

362695
type: SpeciesReference
stoichiometry: 1.0
species: 324084

324084
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: _1D-myo-Inositol 1,3,4,5,6-pentakisphosphate_C6H7O21P5

362634
type: SpeciesReference
stoichiometry: 1.0
species: 327254

327254
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: Diphosphoinositol tetrakisphosphate_C6H7O24P6

362658
type: SpeciesReference
stoichiometry: 1.0
species: 324278

324278
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: myo-Inositol hexakisphosphate_C6H6O24P6

362719
type: SpeciesReference
stoichiometry: 2.0
species: 326951

362731
type: SpeciesReference
stoichiometry: 1.0
species: 324290

324290
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: myo-Inositol hexakisphosphate_C6H6O24P6

362622
type: SpeciesReference
stoichiometry: 1.0
species: 327230

362683
type: SpeciesReference
stoichiometry: 1.0
species: 324096

324096
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303835
name: _1D-myo-Inositol 1,3,4,5,6-pentakisphosphate_C6H7O21P5

362671
type: SpeciesReference
stoichiometry: 2.0
species: 319014

362598
type: SpeciesReference
stoichiometry: 2.0
species: 318846

362646
type: SpeciesReference
stoichiometry: 2.0
species: 326891

362707
type: SpeciesReference
stoichiometry: 2.0
species: 318954

362586
type: SpeciesReference
stoichiometry: 1.0
species: 327242

327242
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: Diphosphoinositol tetrakisphosphate_C6H7O24P6

362610
type: SpeciesReference
stoichiometry: 2.0
species: 318906

973558
type: Reaction
product: 394607
reactant: 394535
product: 394583
reversible: false
reactant: 394571
name: cytochrome p450 P450 3A43
is: ENSRNOG00000000978.3
notes: R_P4503A43r subsystem: Steroid Metabolism R_P4503A43r equation: [r] : h + nadph + o2 + tststerone --> h2o + nadp + whtststerone
is: ENSRNOG00000001379.3
is: ENSRNOG00000000969.4
fast: false
reactant: 394547
is: ENSRNOG00000032560.1
product: 394595
reactant: 394559

394607
type: SpeciesReference
stoichiometry: 1.0
species: 324845

394535
type: SpeciesReference
stoichiometry: 1.0
species: 325440

394583
type: SpeciesReference
stoichiometry: 1.0
species: 331538

331538
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: w hydroxy testosterone_C19H28O3

394571
type: SpeciesReference
stoichiometry: 1.0
species: 319026

394547
type: SpeciesReference
stoichiometry: 1.0
species: 324905

394595
type: SpeciesReference
stoichiometry: 1.0
species: 318918

394559
type: SpeciesReference
stoichiometry: 1.0
species: 330574

331890
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303799
name: Xyl-L-Ser (protein)_C5H9O4X

976979
type: Reaction
reactant: 429356
product: 429392
is: ENSRNOG00000013388.3
product: 429404
notes: R_GPIDAer subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIDAer equation: [r] : gpi_prot_hs + h2o --> dgpi_prot_hs + h + hdca R_GPIDA2er subsystem: Glycosylphosphatidylinositol (GPI)-anchor biosynthesis R_GPIDA2er equation: [r] : em2emgacpail_prot_hs + h2o --> dem2emgacpail_prot_hs + h + hdca
fast: false
product: 429368
reversible: false
reactant: 429332
reactant: 429344
product: 429380

429356
type: SpeciesReference
stoichiometry: 1.0
species: 315324

429392
type: SpeciesReference
stoichiometry: 1.0
species: 313716

313716
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303775
name: deacylated-glycophosphatidylinositol (GPI)-anchored protein_C39H76N4O37P4FULLRCO2FULLR2CO2X

429404
type: SpeciesReference
stoichiometry: 2.0
species: 319026

429368
type: SpeciesReference
stoichiometry: 2.0
species: 319194

429332
type: SpeciesReference
stoichiometry: 2.0
species: 318918

429344
type: SpeciesReference
stoichiometry: 1.0
species: 318366

429380
type: SpeciesReference
stoichiometry: 1.0
species: 313607

306619
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: haxglutamyl folate (DHF)_C44H49N12O21

329872
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: tetracosatetraenoyl coenzyme A_C45H70N7O17P3S

967616
type: Reaction
is: ENSRNOG00000012027.3
fast: false
reactant: 339208
is: http://identifiers.org/ec-code/1.14.99.36
name: beta-Carotene dioxygenase
reversible: false
notes: R_BCDO subsystem: Vitamin A Metabolism R_BCDO equation: [c] : caro + o2 --> (2) retinal
product: 339232
reactant: 339220

339208
type: SpeciesReference
stoichiometry: 1.0
species: 310782

310782
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: beta-Carotene_C40H56

339232
type: SpeciesReference
stoichiometry: 2.0
species: 328254

339220
type: SpeciesReference
stoichiometry: 1.0
species: 325392

975719
type: Reaction
reversible: false
is: ENSRNOG00000022305.3
is: ENSRNOG00000029178.2
product: 416351
reactant: 416276
product: 416338
product: 416313
reactant: 416288
reactant: 416264
fast: false
product: 416325
reactant: 416252
notes: R_CAMPt subsystem: Transport, Extracellular R_CAMPt equation: atp[c] + camp[c] + h2o[c] --> adp[c] + camp[e] + h[c] + pi[c] R_CGMPt subsystem: Transport, Extracellular R_CGMPt equation: _35cgmp[c] + atp[c] + h2o[c] --> 35cgmp[e] + adp[c] + h[c] + pi[c]
product: 416301

416351
type: SpeciesReference
stoichiometry: 1.0
species: 304905

304905
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303787
name: _3',5'-Cyclic GMP_C10H11N5O7P

416276
type: SpeciesReference
stoichiometry: 1.0
species: 304893

416338
type: SpeciesReference
stoichiometry: 2.0
species: 318954

416313
type: SpeciesReference
stoichiometry: 1.0
species: 310745

416288
type: SpeciesReference
stoichiometry: 2.0
species: 318846

416264
type: SpeciesReference
stoichiometry: 2.0
species: 310142

416325
type: SpeciesReference
stoichiometry: 2.0
species: 308621

416252
type: SpeciesReference
stoichiometry: 1.0
species: 310733

416301
type: SpeciesReference
stoichiometry: 2.0
species: 326891

321793
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303811
name: keratan sulfate II (core 2-linked), degradation product 1_C70H113N5O59S3X

970059
type: Reaction
reactant: 361052
product: 361172
reactant: 361088
notes: R_LCADim subsystem: Pyruvate Metabolism R_LCADim equation: [m] : h2o + lald-L + nad --> (2) h + lac-L + nadh R_GCALDDm subsystem: Glyoxylate and Dicarboxylate Metabolism R_GCALDDm equation: [m] : gcald + h2o + nad --> glyclt + (2) h + nadh R_G5SDym subsystem: Urea cycle/amino group metabolism R_G5SDym equation: [m] : glu5p + h + nadph --> glu5sa + nadp + pi R_GLU5Km subsystem: Urea cycle/amino group metabolism R_GLU5Km equation: [m] : atp + glu-L --> adp + glu5p R_AGPRim subsystem: Urea cycle/amino group metabolism R_AGPRim equation: [m] : acg5p + h + nadph --> acg5sa + nadp + pi R_LCADi_Dm subsystem: Pyruvate Metabolism R_LCADi_Dm equation: [m] : h2o + lald-D + nad --> (2) h + lac-D + nadh
product: 361124
reactant: 361027
product: 361112
reactant: 361100
reactant: 361039
reactant: 361003
product: 361196
is: http://identifiers.org/ec-code/2.7.2.11
product: 361232
product: 361136
reactant: 361015
is: http://identifiers.org/ec-code/1.2.1.41
reversible: false
product: 361160
fast: false
reactant: 361076
product: 361208
reactant: 361064
is: http://identifiers.org/ec-code/1.2.1.21
product: 361148
reactant: 360979
is: ENSRNOG00000015267.4
is: http://identifiers.org/ec-code/1.2.1.38
reactant: 360991
product: 361184
product: 361220

361052
type: SpeciesReference
stoichiometry: 1.0
species: 322398

361172
type: SpeciesReference
stoichiometry: 1.0
species: 322311

361088
type: SpeciesReference
stoichiometry: 2.0
species: 319002

361124
type: SpeciesReference
stoichiometry: 1.0
species: 307957

307957
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: N-Acetyl-L-glutamate 5-semialdehyde_C7H10NO4

361027
type: SpeciesReference
stoichiometry: 1.0
species: 310166

361112
type: SpeciesReference
stoichiometry: 1.0
species: 317656

317656
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: L-Glutamate 5-phosphate_C5H8NO7P

361100
type: SpeciesReference
stoichiometry: 1.0
species: 317192

361039
type: SpeciesReference
stoichiometry: 1.0
species: 307945

307945
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303823
name: N-Acetyl-L-glutamyl 5-phosphate_C7H9NO8P

361003
type: SpeciesReference
stoichiometry: 1.0
species: 322373

361196
type: SpeciesReference
stoichiometry: 1.0
species: 322349

361232
type: SpeciesReference
stoichiometry: 3.0
species: 324761

361136
type: SpeciesReference
stoichiometry: 1.0
species: 318064

361015
type: SpeciesReference
stoichiometry: 1.0
species: 317722

361160
type: SpeciesReference
stoichiometry: 1.0
species: 308645

361076
type: SpeciesReference
stoichiometry: 2.0
species: 324881

361208
type: SpeciesReference
stoichiometry: 2.0
species: 324821

361064
type: SpeciesReference
stoichiometry: 3.0
species: 324700

361148
type: SpeciesReference
stoichiometry: 2.0
species: 326939

360979
type: SpeciesReference
stoichiometry: 1.0
species: 317656

360991
type: SpeciesReference
stoichiometry: 3.0
species: 318894

361184
type: SpeciesReference
stoichiometry: 1.0
species: 317669

361220
type: SpeciesReference
stoichiometry: 6.0
species: 319002

306919
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: acyl carrier protein_C11H21N2O7PRS

970811
type: Reaction
reactant: 367858
is: http://identifiers.org/ec-code/3.4.13.3
notes: R_NBAHH_ir subsystem: beta-Alanine metabolism R_NBAHH_ir equation: [c] : carn + h2o --> ala-B + his-L
product: 367894
reversible: false
product: 367882
reactant: 367870
fast: false
is: ENSRNOG00000027739.3
name: Nalpha-(beta-alanyl)-L-histidine hydrolase IR

367858
type: SpeciesReference
stoichiometry: 1.0
species: 318846

367894
type: SpeciesReference
stoichiometry: 1.0
species: 309166

367882
type: SpeciesReference
stoichiometry: 1.0
species: 319446

367870
type: SpeciesReference
stoichiometry: 1.0
species: 310770

310770
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: NaN
in compartment: 303763
name: L-Carnosine_C9H14N4O3

971480
type: Reaction
fast: false
is: ENSRNOG00000016223.4
name: pyruvate dehydrogenase
is: http://identifiers.org/ec-code/1.2.4.1
reactant: 373601
is: ENSRNOG00000007895.3
reactant: 373577
is: ENSRNOG00000014745.2
is: ENSRNOG00000025383.3
product: 373613
notes: R_PDHm subsystem: Glycolysis/Gluconeogenesis R_PDHm equation: [m] : coa + nad + pyr --> accoa + co2 + nadh
reactant: 373589
product: 373637
product: 373625
is: ENSRNOG00000009994.4
reversible: false

373601
type: SpeciesReference
stoichiometry: 1.0
species: 324700