MODEL1006230120
type: SBMLModel
units def: 745433
parameter: 030366
parameter: 030386
rule: 030352
volume units: 290956
parameter: 030374
length unit: 821056
parameter: 030380
modified:
  W3 CDTF: Wed Jun 23 18:03:51 BST 2010
modified:
  W3 CDTF: Wed Jun 23 18:03:51 BST 2010
parameter: 030362
parameter: 030382
rule: 030356
parameter: 030370
rule: 030347
parameter: 030377
parameter: 030364
parameter: 030365
parameter: 030385
rule: 030351
compartment: 030343
parameter: 030373
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Paul
    family: Harrington
parameter: 030393
substance units: 178797
parameter: 030360
modified:
  W3 CDTF: Wed Jun 23 18:03:51 BST 2010
parameter: 030361
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Paul
    family: Harrington
parameter: 030381
parameter: 030358
rule: 030355
parameter: 030388
curated: false
rule: 030348
is described by: http://identifiers.org/pubmed/18049823
parameter: 030376
created:
  W3 CDTF: Wed Jun 23 18:03:51 BST 2010
units def: 745409
units def: 745530
units def: 745494
rule: 030354
parameter: 030378
parameter: 030384
parameter: 030372
parameter: 030392
units def: 745469
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Paul
    family: Harrington
time units: 722430
rule: 030350
name: Siebert2008_MuscleContraction_CCSEC
parameter: 030390
notes: This a model from the article: Nonlinearities make a difference: comparison of two common Hill-type models with real muscle. Siebert T, Rode C, Herzog W, Till O, Blickhan R. Biol Cybern 2008 Feb;98(2):133-43 18049823 , Abstract: Compared to complex structural Huxley-type models, Hill-type models phenomenologically describe muscle contraction using only few state variables. The Hill-type models dominate in the ever expanding field of musculoskeletal simulations for simplicity and low computational cost. Reasonable parameters are required to gain insight into mechanics of movement. The two most common Hill-type muscle models used contain three components. The series elastic component is connected in series to the contractile component. A parallel elastic component is either connected in parallel to both the contractile and the series elastic component (model [CC+SEC]), or is connected in parallel only with the contractile component (model [CC]). As soon as at least one of the components exhibits substantial nonlinearities, as, e.g., the contractile component by the ability to turn on and off, the two models are mechanically different. We tested which model ([CC+SEC] or [CC]) represents the cat soleus better. Ramp experiments consisting of an isometric and an isokinetic part were performed with an in situ cat soleus preparation using supramaximal nerve stimulation. Hill-type models containing force-length and force-velocity relationship, excitation-contraction coupling and series and parallel elastic force-elongation relations were fitted to the data. To test which model might represent the muscle better, the obtained parameters were compared with experimentally determined parameters. Determined in situations with negligible passive force, the force-velocity relation and the series elastic component relation are independent of the chosen model. In contrast to model [CC+SEC], these relations predicted by model [CC] were in accordance with experimental relations. In conc…
parameter: 030368
parameter: 030369
parameter: 030389
area units: 237671

745433
type: SBMLUnitsDef
unit: 745457
unit: 745445
name: mm_per_second

745457
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

745445
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: METRE

030366
type: Parameter
constant: true
value: 5.8
name: curv

030386
type: Parameter
constant: true
value: 4.1
name: delta_L_sec1

030374
type: Parameter
constant: true
value: 0.3
name: L_m

030380
type: Parameter
constant: false
value: NaN
name: f_v

030362
type: Parameter
constant: true
value: 19.0
name: L_4

030382
type: Parameter
constant: false
value: NaN
name: f_sec

030370
type: Parameter
constant: true
value: 4.1
name: F_1

030377
type: Parameter
constant: true
value: 0.006
name: tau

030364
type: Parameter
constant: true
value: 0.49
name: f_c

030365
type: Parameter
constant: true
value: -141.0
name: v_max

030385
type: Parameter
constant: false
value: NaN
name: delta_L_sec

030343
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

030373
type: Parameter
constant: true
value: 3.3
name: k_sh

030393
type: Parameter
constant: true
value: 0.3
name: L_mslack

030360
type: Parameter
constant: true
value: -14.0
name: L_2

030361
type: Parameter
constant: true
value: 2.0
name: L_3

030381
type: Parameter
constant: false
value: NaN
name: f_L

030358
type: Parameter
constant: true
value: -23.0
name: L_1

030388
type: Parameter
constant: false
value: 0.2
name: delta_L_pec

030376
type: Parameter
constant: true
value: 18.1
name: F_im

745409
type: SBMLUnitsDef
unit: 745421
name: mm

745421
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: METRE

745530
type: SBMLUnitsDef
unit: 745566
unit: 745554
unit: 745542
name: mm_newton_per_second

745566
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

745554
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: NEWTON

745542
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: METRE

745494
type: SBMLUnitsDef
unit: 745518
unit: 745506
name: newton_per_mm

745518
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: METRE

745506
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: NEWTON

030378
type: Parameter
constant: false
value: NaN
name: v_cc

030384
type: Parameter
constant: false
value: NaN
name: f_pec

030372
type: Parameter
constant: true
value: 4.1
name: d_LSEC1

030392
type: Parameter
constant: true
value: 1.0
name: A

745469
type: SBMLUnitsDef
unit: 745481
name: per_mm

745481
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: METRE

030390
type: Parameter
constant: false
value: NaN
name: L_mtc

030368
type: Parameter
constant: true
value: 0.012
name: k_1

030369
type: Parameter
constant: true
value: 0.317
name: k_2

030389
type: Parameter
constant: true
value: 3.5
name: k