MODEL1006230117
type: SBMLModel
parameter: 201902
rule: 201874
parameter: 201996
parameter: 202067
rule: 201829
rule: 201894
parameter: 202044
parameter: 201914
rule: 201862
parameter: 201971
parameter: 202079
rule: 201855
parameter: 202098
rule: 201876
parameter: 201923
parameter: 202007
rule: 201889
rule: 201882
rule: 201847
units def: 731263
parameter: 202056
rule: 201891
parameter: 201983
parameter: 202040
rule: 201864
parameter: 202019
parameter: 202025
parameter: 201989
units def: 731288
units def: 731227
parameter: 202068
parameter: 201995
parameter: 202052
rule: 201828
rule: 201837
parameter: 202037
parameter: 202061
name: Iancu2007_CardiacMyoscytes_cAMPsignaling
parameter: 202064
rule: 201888
parameter: 201978
parameter: 202049
parameter: 202073
volume units: 290956
rule: 201867
rule: 201880
parameter: 202085
parameter: 202029
parameter: 201921
parameter: 202011
parameter: 202097
parameter: 202004
parameter: 201968
parameter: 202058
notes: This a model from the article: Compartmentation of cAMP signaling in cardiac myocytes: a computational study. Iancu RV, Jones SW, Harvey RD. Biophys J 2007 May 1;92(9):3317-31 17293406 , Abstract: Receptor-mediated changes in cAMP production play an essential role in sympathetic and parasympathetic regulation of the electrical, mechanical, and metabolic activity of cardiac myocytes. However, responses to receptor activation cannot be easily ascribed to a uniform increase or decrease in cAMP activity throughout the entire cell. In this study, we used a computational approach to test the hypothesis that in cardiac ventricular myocytes the effects of beta(1)-adrenergic receptor (beta(1)AR) and M(2) muscarinic receptor (M(2)R) activation involve compartmentation of cAMP. A model consisting of two submembrane (caveolar and extracaveolar) microdomains and one bulk cytosolic domain was created using published information on the location of beta(1)ARs and M(2)Rs, as well as the location of stimulatory (G(s)) and inhibitory (G(i)) G-proteins, adenylyl cyclase isoforms inhibited (AC5/6) and stimulated (AC4/7) by G(i), and multiple phosphodiesterase isoforms (PDE2, PDE3, and PDE4). Results obtained with the model indicate that: 1), bulk basal cAMP can be high ( approximately 1 microM) and only modestly stimulated by beta(1)AR activation ( approximately 2 microM), but caveolar cAMP varies in a range more appropriate for regulation of protein kinase A ( approximately 100 nM to approximately 2 microM); 2), M(2)R activation strongly reduces the beta(1)AR-induced increases in caveolar cAMP, with less effect on bulk cAMP; and 3), during weak beta(1)AR stimulation, M(2)R activation not only reduces caveolar cAMP, but also produces a rebound increase in caveolar cAMP following termination of M(2)R activity. We conclude that compartmentation of cAMP can provide a quantitative explanation for several aspects of cardiac signaling. This model was taken from the CellML repository and autom…
parameter: 202023
rule: 201877
parameter: 202016
rule: 201835
length unit: 821056
parameter: 202094
parameter: 201964
parameter: 202035
rule: 201897
parameter: 202028
rule: 201852
parameter: 202071
units def: 731385
rule: 201834
rule: 201859
rule: 201840
rule: 201861
parameter: 201903
rule: 201868
parameter: 201974
parameter: 202002
parameter: 201915
parameter: 201972
parameter: 202008

201902
type: Parameter
constant: false
value: NaN
name: L_iso

201996
type: Parameter
constant: false
value: 6.2979E-4
name: Gi_alpha_GDP

202067
type: Parameter
constant: true
value: 5.6
name: PDE3

202044
type: Parameter
constant: true
value: 0.2
name: AC_47_ecav

201914
type: Parameter
constant: true
value: 20.0
name: k_PDE2

201971
type: Parameter
constant: false
value: NaN
name: R

202079
type: Parameter
constant: false
value: NaN
name: dcAMP_cyt_PDE4_dt

202098
type: Parameter
constant: true
value: 1.5E-17
name: J_ecav_cyt

201923
type: Parameter
constant: true
value: 5.0
name: k_act1

202007
type: Parameter
constant: true
value: 0.633
name: R_Total

731263
type: SBMLUnitsDef
unit: 731275
name: per_sec

731275
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

202056
type: Parameter
constant: true
value: 130.0
name: AF47

201983
type: Parameter
constant: false
value: NaN
name: RG

202040
type: Parameter
constant: true
value: 315.0
name: Km_ATP

202019
type: Parameter
constant: false
value: 6.56025E-4
name: Gs_alpha_GDP

202025
type: Parameter
constant: false
value: 0.001475253
name: Gi_beta_gamma

201989
type: Parameter
constant: false
value: 6.51061E-4
name: Gs_alpha_GDP

731288
type: SBMLUnitsDef
unit: 731325
unit: 731313
unit: 731301
name: uM_per_sec

731325
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

731313
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

731301
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

731227
type: SBMLUnitsDef
unit: 731251
unit: 731239
name: per_uM

731251
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

731239
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

202068
type: Parameter
constant: true
value: 2.0
name: PDE4

201995
type: Parameter
constant: false
value: 0.013274751
name: Gi_beta_gamma

202052
type: Parameter
constant: false
value: NaN
name: dcAMP_AC_47_cyt_dt

202037
type: Parameter
constant: true
value: 130.0
name: MW_AC56

202061
type: Parameter
constant: false
value: NaN
name: dcAMP_cav_PDE2_dt

202064
type: Parameter
constant: false
value: NaN
name: dcAMP_cav_PDE4_dt

201978
type: Parameter
constant: false
value: NaN
name: R

202049
type: Parameter
constant: true
value: 5000.0
name: ATP

202073
type: Parameter
constant: true
value: 0.02
name: PDE2

202085
type: Parameter
constant: false
value: 0.11750433
name: cAMP_cav

202029
type: Parameter
constant: true
value: 1.0
name: Gi_Total

201921
type: Parameter
constant: true
value: 2.2
name: Km_PDE4

202011
type: Parameter
constant: false
value: NaN
name: LRG

202097
type: Parameter
constant: true
value: 7.5E-14
name: J_cav_cyt

202004
type: Parameter
constant: false
value: NaN
name: LRG

201968
type: Parameter
constant: true
value: 0.8
name: k_hydr

202058
type: Parameter
constant: true
value: 5000.0
name: ATP

202023
type: Parameter
constant: false
value: 0.001018705
name: Gi_alpha_GTP

202016
type: Parameter
constant: false
value: 0.083866891
name: Gs_alpha_GTP

202094
type: Parameter
constant: true
value: 3.8E-11
name: V_cell

201964
type: Parameter
constant: true
value: 1210.0
name: k_reas

202035
type: Parameter
constant: true
value: 500.0
name: AF56

202028
type: Parameter
constant: false
value: NaN
name: Gi_alpha_beta_gamma

202071
type: Parameter
constant: false
value: NaN
name: dcAMP_ecav_PDE4_dt

731385
type: SBMLUnitsDef
unit: 731409
unit: 731397
name: liters_per_second

731409
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

731397
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

201903
type: Parameter
constant: true
value: 0.035
name: K_H

201974
type: Parameter
constant: false
value: NaN
name: LRG

202002
type: Parameter
constant: false
value: NaN
name: LR

201915
type: Parameter
constant: true
value: 50.0
name: Km_PDE2

201972
type: Parameter
constant: false
value: NaN
name: LR

202008
type: Parameter
constant: false
value: NaN
name: R

201986
type: Parameter
constant: false
value: 0.041983438
name: Gs_alpha_GTP

202076
type: Parameter
constant: false
value: NaN
name: dcAMP_cyt_PDE2_dt

201984
type: Parameter
constant: true
value: 0.633
name: R_Total

202041
type: Parameter
constant: false
value: NaN
name: dcAMP_AC_47_ecav_dt

201912
type: Parameter
constant: true
value: 30.0
name: K_C

201998
type: Parameter
constant: false
value: NaN
name: Gi_alpha_beta_gamma

202088
type: Parameter
constant: false
value: 0.992583576
name: cAMP_cyt

202053
type: Parameter
constant: true
value: 0.00108
name: k_AC47_cyt

201980
type: Parameter
constant: false
value: NaN
name: LR

731190
type: SBMLUnitsDef
unit: 731215
unit: 731202
name: uM

731215
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multipler: 1.0
kind: LITRE

731202
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

201909
type: Parameter
constant: true
value: 0.16
name: K_H

202031
type: Parameter
constant: false
value: NaN
name: dcAMP_AC_56_dt

202050
type: Parameter
constant: true
value: 315.0
name: Km_ATP

731421
type: SBMLUnitsDef
unit: 731445
unit: 731433
name: kDa

731445
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE

731433
type: SBMLUnit
exponent: 1.0
scale: 3
multipler: 1.0
kind: GRAM

202062
type: Parameter
constant: false
value: NaN
name: dcAMP_cav_PDE3_dt

202047
type: Parameter
constant: true
value: 130.0
name: MW_AC47

202020
type: Parameter
constant: false
value: NaN
name: Gs_alpha_beta_gamma

202074
type: Parameter
constant: true
value: 0.16
name: PDE4

202005
type: Parameter
constant: false
value: NaN
name: RG

201969
type: Parameter
constant: true
value: 1210.0
name: k_reas

202083
type: Parameter
constant: true
value: 0.005
name: PDE4

202059
type: Parameter
constant: true
value: 315.0
name: Km_ATP

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

202086
type: Parameter
constant: false
value: 1.092200547
name: cAMP_ecav

202017
type: Parameter
constant: false
value: 0.084522918
name: Gs_beta_gamma

201911
type: Parameter
constant: true
value: 11.0
name: K_L

202001
type: Parameter
constant: false
value: NaN
name: R

202095
type: Parameter
constant: true
value: 7.5E-15
name: J_cav_ecav

201965
type: Parameter
constant: true
value: 2.5
name: k_act1

202013
type: Parameter
constant: false
value: NaN
name: RG

201990
type: Parameter
constant: false
value: NaN
name: Gs_alpha_beta_gamma

201977
type: Parameter
constant: true
value: 0.633
name: R_Total

202091
type: Parameter
constant: false
value: NaN
name: V_ecav

202014
type: Parameter
constant: true
value: 0.633
name: R_Total

W3 CDTF: Wed Jun 23 18:06:44 BST 2010

202026
type: Parameter
constant: false
value: 4.56548E-4
name: Gi_alpha_GDP

201963
type: Parameter
constant: true
value: 0.8
name: k_hydr

201920
type: Parameter
constant: true
value: 2.5
name: k_PDE4

202010
type: Parameter
constant: false
value: NaN
name: LR

201905
type: Parameter
constant: true
value: 0.386
name: K_L

201966
type: Parameter
constant: true
value: 0.05
name: k_act2

202080
type: Parameter
constant: true
value: 0.005
name: PDE2

W3 CDTF: Wed Jun 23 18:06:44 BST 2010

202038
type: Parameter
constant: true
value: 5000.0
name: ATP

201908
type: Parameter
constant: false
value: NaN
name: L_ach

201975
type: Parameter
constant: false
value: NaN
name: RG

202065
type: Parameter
constant: true
value: 4.5
name: PDE2

202022
type: Parameter
constant: true
value: 10.0
name: Gs_Total

201992
type: Parameter
constant: true
value: 10.0
name: Gs_Total

201917
type: Parameter
constant: true
value: 1.25
name: k_PDE3

202092
type: Parameter
constant: false
value: NaN
name: V_cyt

201987
type: Parameter
constant: false
value: 0.042634499
name: Gs_beta_gamma

202077
type: Parameter
constant: false
value: NaN
name: dcAMP_cyt_PDE3_dt

202034
type: Parameter
constant: true
value: 3.379
name: AC_56

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

202043
type: Parameter
constant: false
value: NaN
name: k_AC47_ecav

731337
type: SBMLUnitsDef
unit: 731373
unit: 731361
unit: 731349
name: per_uM_per_sec

731373
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

731361
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

731349
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

201962
type: Parameter
constant: true
value: 0.1
name: k_act2

202089
type: Parameter
constant: false
value: NaN
name: V_cav

201999
type: Parameter
constant: true
value: 20.0
name: Gi_Total

201981
type: Parameter
constant: false
value: NaN
name: LRG

202070
type: Parameter
constant: false
value: NaN
name: dcAMP_ecav_PDE2_dt

202046
type: Parameter
constant: true
value: 130.0
name: AF47

201906
type: Parameter
constant: true
value: 8.809
name: K_C

202055
type: Parameter
constant: true
value: 0.136
name: AC_47_cyt

201820
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

201993
type: Parameter
constant: false
value: 0.012644961
name: Gi_alpha_GTP

202082
type: Parameter
constant: true
value: 0.0075
name: PDE3

201918
type: Parameter
constant: true
value: 0.08
name: Km_PDE3

202032
type: Parameter
constant: false
value: NaN
name: k_AC56

W3 CDTF: Wed Jun 23 18:06:44 BST 2010

W3 CDTF: Wed Jun 23 18:06:44 BST 2010

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns