MODEL1006230116
type: SBMLModel
units def: 726974
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parameter: 651639
created:
  W3 CDTF: Fri Jun 25 14:57:32 BST 2010
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length unit: 821056
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units def: 727059
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parameter: 651621
parameter: 651606
time units: 722430
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
is described by: http://identifiers.org/pubmed/20338848
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units def: 727095
modified:
  W3 CDTF: Fri Jun 25 14:57:32 BST 2010
parameter: 651626
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
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creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 651603
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notes: This a model from the article: A metabolite-sensitive, thermodynamically constrained model of cardiac cross-bridge cycling: implications for force development during ischemia. Tran K, Smith NP, Loiselle DS, Crampin EJ. Biophys J 2010 Jan 20;98(2):267-76 20338848 , Abstract: We present a metabolically regulated model of cardiac active force generation with which we investigate the effects of ischemia on maximum force production. Our model, based on a model of cross-bridge kinetics that was developed by others, reproduces many of the observed effects of MgATP, MgADP, Pi, and H(+) on force development while retaining the force/length/Ca(2+) properties of the original model. We introduce three new parameters to account for the competitive binding of H(+) to the Ca(2+) binding site on troponin C and the binding of MgADP within the cross-bridge cycle. These parameters, along with the Pi and H(+) regulatory steps within the cross-bridge cycle, were constrained using data from the literature and validated using a range of metabolic and sinusoidal length perturbation protocols. The placement of the MgADP binding step between two strongly-bound and force-generating states leads to the emergence of an unexpected effect on the force-MgADP curve, where the trend of the relationship (positive or negative) depends on the concentrations of the other metabolites and [H(+)]. The model is used to investigate the sensitivity of maximum force production to changes in metabolite concentrations during the development of ischemia. Copyright 2010 Biophysical Society. Published by Elsevier Inc. All rights reserved. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Tran K, Smith NP, Loiselle DS, Crampin EJ. (2009) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.eb…
rule: 651579
parameter: 651591
name: Tran2009_CardiacActiveForceGeneration
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modified:
  W3 CDTF: Fri Jun 25 14:57:32 BST 2010
parameter: 651634
modified:
  W3 CDTF: Fri Jun 25 14:57:32 BST 2010
parameter: 651604
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