MODEL1006230114
type: SBMLModel
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parameter: 596182
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parameter: 596213
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time units: 717890
volume units: 290956
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is described by: http://identifiers.org/pubmed/16945388
parameter: 596227
area units: 237671
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parameter: 596232
parameter: 596175
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parameter: 596205
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parameter: 596215
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parameter: 596163
rule: 596115
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notes: This a model from the article: A simplified model for mitochondrial ATP production. Bertram R, Gram Pedersen M, Luciani DS, Sherman A. J Theor Biol 2006 Dec 21;243(4):575-86 16945388 , Abstract: Most of the adenosine triphosphate (ATP) synthesized during glucose metabolism is produced in the mitochondria through oxidative phosphorylation. This is a complex reaction powered by the proton gradient across the mitochondrial inner membrane, which is generated by mitochondrial respiration. A detailed model of this reaction, which includes dynamic equations for the key mitochondrial variables, was developed earlier by Magnus and Keizer. However, this model is extraordinarily complicated. We develop a simpler model that captures the behavior of the original model but is easier to use and to understand. We then use it to investigate the mitochondrial responses to glycolytic and calcium input. We use the model to explain experimental observations of the opposite effects of raising cytosolic Ca(2+)in low and high glucose, and to predict the effects of a mutation in the mitochondrial enzyme nicotinamide nucleotide transhydrogenase (Nnt) in pancreatic beta-cells. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Bertram R, Gram Pedersen M, Luciani DS, Sherman A. (2006) - version=1.0 The original CellML model was created by: Tessa Paris tpar054@aucklanduni.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or em…
parameter: 596187
rule: 596107
parameter: 596234
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596246
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value: 10.0
name: p13

596208
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name: heav_Ctoff2

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type: Parameter
constant: false
value: NaN
name: MM2

596195
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value: 210000.0
name: Ctoff2

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value: 120000.0
name: Cton1

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name: p9

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596239
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type: Parameter
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name: pulse3

596163
type: Parameter
constant: true
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name: Chold

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W3 CDTF: Fri Jun 25 14:56:38 BST 2010

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ORG:
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n:
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name: Jh_res

W3 CDTF: Fri Jun 25 14:56:38 BST 2010

ORG:
  orgname: The University of Auckland
n:
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596218
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596156
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ORG:
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596224
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W3 CDTF: Fri Jun 25 14:56:38 BST 2010

W3 CDTF: Fri Jun 25 14:56:38 BST 2010