MODEL1006230110
type: SBMLModel
parameter: 457589
parameter: 457568
modified:
  W3 CDTF: Fri Jun 25 14:54:18 BST 2010
units def: 698030
compartment: 457531
parameter: 457590
parameter: 457594
modified:
  W3 CDTF: Fri Jun 25 14:54:18 BST 2010
units def: 697836
area units: 237671
units def: 697909
created:
  W3 CDTF: Fri Jun 25 14:54:18 BST 2010
rule: 457562
rule: 457558
rule: 457535
parameter: 457587
parameter: 457585
units def: 698005
units def: 697981
notes: This a model from the article: Sleep deprivation in a quantitative physiologically based model of the ascending arousal system. Phillips AJ, Robinson PA. J Theor Biol 2008 Dec 21;255(4):413-23 18805427 , Abstract: A physiologically based quantitative model of the human ascending arousal system is used to study sleep deprivation after being calibrated on a small set of experimentally based criteria. The model includes the sleep-wake switch of mutual inhibition between nuclei which use monoaminergic neuromodulators, and the ventrolateral preoptic area. The system is driven by the circadian rhythm and sleep homeostasis. We use a small number of experimentally derived criteria to calibrate the model for sleep deprivation, then investigate model predictions for other experiments, demonstrating the scope of application. Calibration gives an improved parameter set, in which the form of the homeostatic drive is better constrained, and its weighting relative to the circadian drive is increased. Within the newly constrained parameter ranges, the model predicts repayment of sleep debt consistent with experiment in both quantity and distribution, asymptoting to a maximum repayment for very long deprivations. Recovery is found to depend on circadian phase, and the model predicts that it is most efficient to recover during normal sleeping phases of the circadian cycle, in terms of the amount of recovery sleep required. The form of the homeostatic drive suggests that periods of wake during recovery from sleep deprivation are phases of relative recovery, in the sense that the homeostatic drive continues to converge toward baseline levels. This undermines the concept of sleep debt, and is in agreement with experimentally restricted recovery protocols. Finally, we compare our model to the two-process model, and demonstrate the power of physiologically based modeling by correctly predicting sleep latency times following deprivation from experimental data. This model was taken from the…
parameter: 457570
substance units: 178797
rule: 457556
length unit: 821056
units def: 698115
parameter: 457579
parameter: 457569
parameter: 457580
name: Phillips2008_AscendingArousalSystem_Baseline
time units: 698115
parameter: 457584
rule: 457560
curated: false
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 457559
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 457575
parameter: 457581
parameter: 457592
volume units: 290956
parameter: 457578
parameter: 457591
units def: 697812
modified:
  W3 CDTF: Fri Jun 25 14:54:18 BST 2010
units def: 698067
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 457583
is described by: http://identifiers.org/pubmed/18805427
rule: 457564
parameter: 457586
units def: 697957
parameter: 457576
rule: 457536
parameter: 457574
parameter: 457571
units def: 697872
parameter: 457573

457589
type: Parameter
constant: true
value: -3.2
name: v_vc

457568
type: Parameter
constant: false
value: NaN
name: Qv

698030
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unit: 698042
name: nM

698055
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698042
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kind: MOLE

457531
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

457590
type: Parameter
constant: true
value: 0.19
name: v_vh

457594
type: Parameter
constant: true
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name: sigma

697836
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697860
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697848
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697909
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697945
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697933
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697921
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457587
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name: alpha

457585
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698005
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name: per_hour

698018
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697981
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unit: 697993
name: hour

697993
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457570
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698115
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name: time

698127
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457579
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name: H

457569
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name: Vv

457580
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value: 11.0
name: chi

457584
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constant: false
value: NaN
name: C

457575
type: Parameter
constant: true
value: 10.0
name: tau_m

457581
type: Parameter
constant: true
value: 3.6
name: mu

457592
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constant: true
value: 10.0
name: theta

457578
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constant: true
value: 1.0
name: A

457591
type: Parameter
constant: true
value: 100.0
name: Qmax

697812
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697824
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698067
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698103
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698091
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698079
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457583
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name: D

457586
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697957
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697969
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457576
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constant: true
value: -1.9
name: v_mv

457574
type: Parameter
constant: false
value: 0.0
name: Vm

457571
type: Parameter
constant: true
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name: v_vm

697872
type: SBMLUnitsDef
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unit: 697884
name: mV_per_second

697896
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697884
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457573
type: Parameter
constant: false
value: NaN
name: Qm