MODEL1006230107
type: SBMLModel
area units: 237671
rule: 375982
parameter: 376004
units def: 686745
modified:
  W3 CDTF: Fri Jun 25 14:52:57 BST 2010
volume units: 290956
units def: 686925
created:
  W3 CDTF: Fri Jun 25 14:52:57 BST 2010
curated: false
parameter: 375994
rule: 375986
rule: 375979
time units: 682338
rule: 375980
is described by: http://identifiers.org/pubmed/7611375
rule: 375984
substance units: 178797
parameter: 375999
modified:
  W3 CDTF: Fri Jun 25 14:52:57 BST 2010
parameter: 376009
parameter: 376001
units def: 686853
modified:
  W3 CDTF: Fri Jun 25 14:52:57 BST 2010
length unit: 821056
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Wei
    family: Liu
parameter: 376006
parameter: 375991
units def: 686877
parameter: 375993
rule: 375985
parameter: 376010
parameter: 375989
parameter: 375996
compartment: 375975
parameter: 375998
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Wei
    family: Liu
notes: This a model from the article: Intercellular calcium waves mediated by diffusion of inositol trisphosphate: a two-dimensional model. Sneyd J, Wetton BT, Charles AC, Sanderson MJ. Am J Physiol 1995 Jun;268(6 Pt 1):C1537-45 7611375 , Abstract: In response to mechanical stimulation of a single cell, airway epithelial cells in culture exhibit a wave of increased intracellular free Ca2+ concentration that spreads from cell to cell over a limited distance through the culture. We present a detailed analysis of the intercellular wave in a two-dimensional sheet of cells. The model is based on the hypothesis that the wave is the result of diffusion of inositol trisphosphate (IP3) from the stimulated cell. The two-dimensional model agrees well with experimental data and makes the following quantitative predictions: as the distance from the stimulated cells increases, 1) the intercellular delay increases exponentially, 2) the intracellular wave speed decreases exponentially, and 3) the arrival time increases exponentially. Furthermore, 4) a proportion of the cells at the periphery of the response will exhibit waves of decreased amplitude, 5) the intercellular membrane permeability to IP3 must be approximately 2 microns/s or greater, and 6) the ratio of the maximum concentration of IP3 in the stimulated cell to the Km of the IP3 receptor (with respect to IP3) must be approximately 300 or greater. These predictions constitute a rigorous test of the hypothesis that the intercellular Ca2+ waves are mediated by IP3 diffusion. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Sneyd J, Wetton BT, Charles AC, Sanderson MJ. (1995) - version=1.0 The original CellML model was created by: Wei Liu wliu052@aucklanduni.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the ex…
rule: 375981
parameter: 376000
parameter: 376008
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Wei
    family: Liu
parameter: 376005
parameter: 376003
units def: 686829
parameter: 375990
parameter: 375988
name: Sneyd1995_CalciumWave_IP3diffusion
units def: 686781
parameter: 376011
parameter: 375995

376004
type: Parameter
constant: false
value: NaN
name: J_leak

686745
type: SBMLUnitsDef
unit: 686769
unit: 686757
name: micromolar

686769
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

686757
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

686925
type: SBMLUnitsDef
unit: 686961
unit: 686949
unit: 686937
name: micromolar_square_per_second

686961
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

686949
type: SBMLUnit
exponent: -2.0
scale: 0
multipler: 1.0
kind: LITRE

686937
type: SBMLUnit
exponent: 2.0
scale: -6
multipler: 1.0
kind: MOLE

375994
type: Parameter
constant: false
value: 0.3
name: c

375999
type: Parameter
constant: true
value: 0.7
name: k_1

376009
type: Parameter
constant: false
value: 1.0
name: h

376001
type: Parameter
constant: true
value: 1.0
name: gamma

686853
type: SBMLUnitsDef
unit: 686865
name: per_sec_square

686865
type: SBMLUnit
exponent: -2.0
scale: 0
multipler: 1.0
kind: SECOND

376006
type: Parameter
constant: false
value: NaN
name: mu

375991
type: Parameter
constant: true
value: 1.0
name: k_p

686877
type: SBMLUnitsDef
unit: 686913
unit: 686901
unit: 686889
name: micromolar_per_second

686913
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

686901
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

686889
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

375993
type: Parameter
constant: true
value: 0.72
name: IPR_3_flux

376010
type: Parameter
constant: true
value: 0.7
name: k_2

375989
type: Parameter
constant: false
value: 0.0
name: P

375996
type: Parameter
constant: true
value: 3.0
name: k_flux

375975
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

375998
type: Parameter
constant: true
value: 0.11
name: b

376000
type: Parameter
constant: false
value: NaN
name: J_pump

376008
type: Parameter
constant: true
value: 0.01
name: k_mu

376005
type: Parameter
constant: true
value: 0.15
name: beta

376003
type: Parameter
constant: true
value: 0.27
name: k_gamma

686829
type: SBMLUnitsDef
unit: 686841
name: per_second

686841
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

375990
type: Parameter
constant: true
value: 0.08
name: V_p

375988
type: Parameter
constant: true
value: NaN
name: time

686781
type: SBMLUnitsDef
unit: 686817
unit: 686805
unit: 686793
name: flux

686817
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

686805
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

686793
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

376011
type: Parameter
constant: true
value: 0.2
name: tau_h

375995
type: Parameter
constant: false
value: NaN
name: J_flux