MODEL1006230105
type: SBMLModel
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notes: This a model from the article: Modelling sarcoplasmic reticulum calcium ATPase and its regulation in cardiac myocytes. Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. Philos Transact A Math Phys Eng Sci 2009 Jun 13;367(1896):2181-202 19414452 , Abstract: When developing large-scale mathematical models of physiology, some reduction in complexity is necessarily required to maintain computational efficiency. A prime example of such an intricate cell is the cardiac myocyte. For the predictive power of the cardiomyocyte models, it is vital to accurately describe the calcium transport mechanisms, since they essentially link the electrical activation to contractility. The removal of calcium from the cytoplasm takes place mainly by the Na(+)/Ca(2+) exchanger, and the sarcoplasmic reticulum Ca(2+) ATPase (SERCA). In the present study, we review the properties of SERCA, its frequency-dependent and beta-adrenergic regulation, and the approaches of mathematical modelling that have been used to investigate its function. Furthermore, we present novel theoretical considerations that might prove useful for the elucidation of the role of SERCA in cardiac function, achieving a reduction in model complexity, but at the same time retaining the central aspects of its function. Our results indicate that to faithfully predict the physiological properties of SERCA, we should take into account the calcium-buffering effect and reversible function of the pump. This 'uncomplicated' modelling approach could be useful to other similar transport mechanisms as well. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. (2009) - version=1.0 The original CellML model was created by: Geoffrey Nunns gnunns1@jhu.edu The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) …
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parameter: 329621
parameter: 329578
name: Koivumaki2009_SERCAATPase_long
curated: false
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329640
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329610
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329624
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329612
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329656
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329592
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329644
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329661
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name: PLB_dephosph

329585
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329617
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329654
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329642
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name: Ca_o

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329646
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329660
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name: LTRPN

329582
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329616
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329653
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329620
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name: eta

W3 CDTF: Fri Jun 25 14:52:11 BST 2010

329641
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W3 CDTF: Fri Jun 25 14:52:11 BST 2010

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W3 CDTF: Fri Jun 25 14:52:11 BST 2010

329593
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329581
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329613
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329618
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329606
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ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

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W3 CDTF: Fri Jun 25 14:52:11 BST 2010

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns