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    orgname: University of Auckland
  n:
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    family: Lloyd
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is described by: http://identifiers.org/pubmed/11842064
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  W3 CDTF: Fri Jun 25 14:51:05 BST 2010
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notes: This a model from the article: Computational modeling of cardiovascular response to orthostatic stress. Heldt T, Shim EB, Kamm RD, Mark RG. J Appl Physiol 2002 Mar;92(3):1239-54 11842064 , Abstract: The objective of this study is to develop a model of the cardiovascular system capable of simulating the short-term (< or = 5 min) transient and steady-state hemodynamic responses to head-up tilt and lower body negative pressure. The model consists of a closed-loop lumped-parameter representation of the circulation connected to set-point models of the arterial and cardiopulmonary baroreflexes. Model parameters are largely based on literature values. Model verification was performed by comparing the simulation output under baseline conditions and at different levels of orthostatic stress to sets of population-averaged hemodynamic data reported in the literature. On the basis of experimental evidence, we adjusted some model parameters to simulate experimental data. Orthostatic stress simulations are not statistically different from experimental data (two-sided test of significance with Bonferroni adjustment for multiple comparisons). Transient response characteristics of heart rate to tilt also compare well with reported data. A case study is presented on how the model is intended to be used in the future to investigate the effects of post-spaceflight orthostatic intolerance. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Heldt T, Shim EB, Kamm RD, Mark RG. (2002) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. …
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  ORG:
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  n:
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    orgname: University of Auckland
  n:
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    family: Lloyd
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