MODEL1006230098
type: SBMLModel
time units: 643152
created:
  W3 CDTF: Fri Jun 25 14:48:24 BST 2010
parameter: 103547
notes: This a model from the article: Macrophage dynamics in diabetic wound dealing. Waugh HV, Sherratt JA. Bull Math Biol 2006 Jan;68(1):197-207 16794927 , Abstract: Wound healing in diabetes is a complex process, characterised by a chronic inflammation phase. The exact mechanism by which this occurs is not fully understood, and whilst several treatments for healing diabetic wounds exist, very little research has been conducted towards the causes of the extended inflammation phase. We describe a mathematical model which offers a possible explanation for diabetic wound healing in terms of the distribution of macrophage phenotypes being altered in the diabetic patient compared to normal wound repair. As a consequence of this, we put forward a suggestion for treatment based on rectifying the macrophage phenotype imbalance. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Waugh HV, Sherratt JA. (2006) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitati…
parameter: 103542
modified:
  W3 CDTF: Fri Jun 25 14:48:24 BST 2010
units def: 642876
units def: 642960
modified:
  W3 CDTF: Fri Jun 25 14:48:24 BST 2010
parameter: 103534
units def: 643152
units def: 643032
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 103528
length unit: 821056
units def: 642840
parameter: 103535
volume units: 290956
parameter: 103545
units def: 643092
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
units def: 643008
name: Waugh2006_WoundHealingMacrophageDynamics_Diabetic_ModelA
rule: 103524
parameter: 103550
parameter: 103533
modified:
  W3 CDTF: Fri Jun 25 14:48:24 BST 2010
curated: false
rule: 103527
parameter: 103538
units def: 642912
parameter: 103530
units def: 643116
units def: 642816
parameter: 103549
parameter: 103546
parameter: 103543
substance units: 178797
parameter: 103541
units def: 643056
compartment: 103521
units def: 642792
is described by: http://identifiers.org/pubmed/16794927
parameter: 103539
rule: 103525
parameter: 103537
area units: 237671
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 103531

643152
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643164
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103547
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value: 0.07
name: k4

643116
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643140
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643128
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103542
type: Parameter
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value: 0.5
name: alpha

642876
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value: 6.0
name: T

643056
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642840
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642852
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103535
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value: NaN
name: K_T

103545
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constant: true
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value: 0.693
name: k2

643092
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643104
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643008
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643020
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103550
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value: 9.1
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103533
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value: 200.0
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103538
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value: 21.94
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642912
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642948
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642936
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103530
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value: NaN
name: time

642792
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642804
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103549
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value: 0.2
name: d1

103546
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constant: true
units: 643008
value: 0.002
name: k3

103543
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constant: true
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value: 0.05
name: k1

103541
type: Parameter
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units: 642840
value: 1.75
name: tau4

103521
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constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

103539
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constant: true
units: 642876
value: 6.41
name: tau3

103537
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value: -2.47
name: tau1

103531
type: Parameter
constant: false
units: 642816
value: 200.0
name: phi_I