MODEL1006230097
type: SBMLModel
parameter: 078635
rule: 078612
rule: 078588
parameter: 078695
parameter: 078623
parameter: 078683
parameter: 078680
substance units: 178797
parameter: 078725
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
modified:
  W3 CDTF: Fri Jun 25 14:47:59 BST 2010
rule: 078603
units def: 638913
curated: false
parameter: 078698
is described by: http://identifiers.org/pubmed/17251133
parameter: 078662
rule: 078609
rule: 078606
parameter: 078713
parameter: 078686
created:
  W3 CDTF: Fri Jun 25 14:47:59 BST 2010
modified:
  W3 CDTF: Fri Jun 25 14:47:59 BST 2010
parameter: 078728
parameter: 078692
parameter: 078650
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 078710
parameter: 078677
rule: 078615
parameter: 078665
parameter: 078626
compartment: 078568
parameter: 078674
area units: 237671
parameter: 078659
parameter: 078722
rule: 078571
parameter: 078689
parameter: 078647
parameter: 078707
parameter: 078644
rule: 078582
parameter: 078671
parameter: 078638
parameter: 078716
rule: 078591
rule: 078594
rule: 078573
rule: 078576
parameter: 078704
length unit: 821056
parameter: 078701
parameter: 078668
rule: 078585
volume units: 290956
parameter: 078629
parameter: 078653
units def: 638938
rule: 078597
rule: 078579
parameter: 078632
parameter: 078641
rule: 078600
rule: 078618
parameter: 078656
parameter: 078719
rule: 078572
parameter: 078620
units def: 638889
modified:
  W3 CDTF: Fri Jun 25 14:47:59 BST 2010
time units: 638938
name: Wodarz2007_CTLinflation_ModelC
notes: This a model from the article: Dynamics of killer T cell inflation in viral infections. Wodarz D, Sierro S, Klenerman P. J R Soc Interface 2007 Jun 22;4(14):533-43 17251133 , Abstract: Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After acute infection had resolved, some antigen specific CTL started to expand over time despite the fact that no replicative virus was detectable. This phenomenon has been termed as "CTL memory inflation". In order to examine the dynamics of this system further, we developed a mathematical model analysing the impact of innate and adaptive immune responses. According to this model, a potentially important contributor to CTL inflation is competition between the specific CTL response and an innate natural killer (NK) cell response. Inflation occurs most readily if the NK cell response is more efficient than the CTL at reducing virus load during acute infection, but thereafter maintains a chronic virus load which is sufficient to induce CTL proliferation. The model further suggests that weaker NK cell mediated protection can correlate with more pronounced CTL inflation dynamics over time. We present experimental data from mice infected with MCMV which are consistent with the theoretical predictions. This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wodarz D, Sierro S, Klenerman P. (2007) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published M…
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd

078635
type: Parameter
constant: false
value: 0.0
name: m_8

078695
type: Parameter
constant: true
value: 0.5
name: gamma

078623
type: Parameter
constant: false
value: 0.0
name: y0

078683
type: Parameter
constant: true
value: 1.0
name: u

078680
type: Parameter
constant: true
value: 1.0
name: k

078725
type: Parameter
constant: true
value: 0.1
name: bi

638913
type: SBMLUnitsDef
unit: 638926
name: first_order_rate_constant

638926
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

078698
type: Parameter
constant: true
value: 0.2
name: alpha

078662
type: Parameter
constant: false
value: 1.0
name: za

078713
type: Parameter
constant: true
value: 1.0
name: r

078686
type: Parameter
constant: true
value: 10.0
name: lambda

078728
type: Parameter
constant: true
value: 0.01
name: xi

078692
type: Parameter
constant: true
value: 0.1
name: beta

078650
type: Parameter
constant: false
value: 0.0
name: m_3

078710
type: Parameter
constant: true
value: 15.5
name: ca

078677
type: Parameter
constant: true
value: 0.2
name: a1

078665
type: Parameter
constant: false
value: 0.1
name: zi

078626
type: Parameter
constant: false
value: 0.0
name: y1

078568
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

078674
type: Parameter
constant: true
value: 0.1
name: a0

078659
type: Parameter
constant: false
value: 0.0
name: m_0

078722
type: Parameter
constant: true
value: 12.0
name: ci

078689
type: Parameter
constant: true
value: 0.1
name: d

078647
type: Parameter
constant: false
value: 0.0
name: m_4

078707
type: Parameter
constant: true
value: 1.0E-6
name: pa

078644
type: Parameter
constant: false
value: 0.0
name: m_5

078671
type: Parameter
constant: false
value: NaN
name: R0

078638
type: Parameter
constant: false
value: 0.0
name: m_7

078716
type: Parameter
constant: true
value: 0.1
name: ba

078704
type: Parameter
constant: true
value: 0.01
name: eta

078701
type: Parameter
constant: true
value: 0.1
name: phi

078668
type: Parameter
constant: false
value: NaN
name: log_zi

078629
type: Parameter
constant: false
value: 0.0
name: L

078653
type: Parameter
constant: false
value: 0.0
name: m_2

638938
type: SBMLUnitsDef
unit: 638951
name: time

638951
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

078632
type: Parameter
constant: false
value: 1.0
name: v

078641
type: Parameter
constant: false
value: 0.0
name: m_6

078656
type: Parameter
constant: false
value: 0.0
name: m_1

078719
type: Parameter
constant: true
value: 1.0
name: p_i

078620
type: Parameter
constant: false
value: 1.0
name: x

638889
type: SBMLUnitsDef
unit: 638901
name: hour

638901
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND