MODEL1006230094
type: SBMLModel
rule: 999463
units def: 625813
parameter: 999476
parameter: 999486
name: Wodarz2003_CTLcrosspriming
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 999471
parameter: 999470
length unit: 821056
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
time units: 625813
created:
  W3 CDTF: Fri Jun 25 14:46:40 BST 2010
rule: 999462
parameter: 999479
parameter: 999478
parameter: 999488
parameter: 999487
rule: 999467
parameter: 999480
curated: false
parameter: 999472
parameter: 999482
parameter: 999469
modified:
  W3 CDTF: Fri Jun 25 14:46:40 BST 2010
area units: 237671
units def: 625765
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
compartment: 999458
volume units: 290956
substance units: 178797
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is described by: http://identifiers.org/pubmed/12706524
parameter: 999490
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notes: This a model from the article: A dynamical perspective of CTL cross-priming and regulation: implications for cancer immunology. Wodarz D, Jansen VA. Immunol Lett 2003 May 1;86(3):213-27 12706524 , Abstract: Cytotoxic T lymphocytes (CTL) responses are required to fight many diseases such as viral infections and tumors. At the same time, they can cause disease when induced inappropriately. Which factors regulate CTL and decide whether they should remain silent or react is open to debate. The phenomenon called cross-priming has received attention in this respect. That is, CTL expansion occurs if antigen is recognized on the surface of professional antigen presenting cells (APCs). This is in contrast to direct presentation where antigen is seen on the surface of the target cells (e.g. infected cells or tumor cells). Here we introduce a mathematical model, which takes the phenomenon of cross-priming into account. We propose a new mechanism of regulation which is implicit in the dynamics of the CTL: According to the model, the ability of a CTL response to become established depends on the ratio of cross-presentation to direct presentation of the antigen. If this ratio is relatively high, CTL responses are likely to become established. If this ratio is relatively low, tolerance is the likely outcome. The behavior of the model includes a parameter region where the outcome depends on the initial conditions. We discuss our results with respect to the idea of self/non-self discrimination and the danger signal hypothesis. We apply the model to study the role of CTL in cancer initiation, cancer evolution/progression, and therapeutic vaccination against cancers. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wodarz D, Jansen VA. (2003) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Ann…
modified:
  W3 CDTF: Fri Jun 25 14:46:40 BST 2010
modified:
  W3 CDTF: Fri Jun 25 14:46:40 BST 2010

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