MODEL1006230091
type: SBMLModel
units def: 611539
parameter: 917055
units def: 611466
parameter: 917034
parameter: 917036
parameter: 917062
parameter: 917040
units def: 611430
parameter: 917057
area units: 237671
parameter: 917039
parameter: 917063
units def: 611564
parameter: 917043
rule: 917016
rule: 917015
parameter: 917051
rule: 917030
rule: 917029
parameter: 917070
rule: 917028
parameter: 917050
parameter: 917066
parameter: 917045
name: Reed2004_MethionineCycle
units def: 611491
parameter: 917054
modified:
  W3 CDTF: Fri Jun 25 14:45:18 BST 2010
parameter: 917073
rule: 917023
parameter: 917068
parameter: 917061
created:
  W3 CDTF: Fri Jun 25 14:45:18 BST 2010
parameter: 917056
parameter: 917038
notes: This a model from the article: A mathematical model of the methionine cycle. Reed MC, Nijhout HF, Sparks R, Ulrich CM. J Theor Biol 2004 Jan 7;226(1):33-43 14637052 , Abstract: Building on the work of Martinov et al. (2000), a mathematical model is developed for the methionine cycle. A large amount of information is available about the enzymes that catalyse individual reaction steps in the cycle, from methionine to S-adenosylmethionine to S-adenosylhomocysteine to homocysteine, and the removal of mass from the cycle by the conversion of homocysteine to cystathionine. Nevertheless, the behavior of the cycle is very complicated since many substrates alter the activities of the enzymes in the reactions that produce them, and some can also alter the activities of other enzymes in the cycle. The model consists of four differential equations, based on known reaction kinetics, that can be solved to give the time course of the concentrations of the four main substrates in the cycle under various circumstances. We show that the behavior of the model in response to genetic abnormalities and dietary deficiencies is similar to the changes seen in a wide variety of experimental studies. We conduct computational "experiments" that give understanding of the regulatory behavior of the methionine cycle under normal conditions and the behavior in the presence of genetic variation and dietary deficiencies. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Reed MC, Nijhout HF, Sparks R, Ulrich CM. (2004) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the …
substance units: 178797
units def: 611612
parameter: 917042
rule: 917018
parameter: 917059
rule: 917017
rule: 917031
rule: 917021
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 917065
length unit: 821056
parameter: 917053
parameter: 917033
parameter: 917072
rule: 917025
rule: 917024
compartment: 917012
parameter: 917067
curated: false
parameter: 917047
parameter: 917049
parameter: 917060
parameter: 917037
units def: 611393
rule: 917019
volume units: 290956
is described by: http://identifiers.org/pubmed/14637052
modified:
  W3 CDTF: Fri Jun 25 14:45:18 BST 2010
rule: 917022
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
time units: 611612
parameter: 917064
parameter: 917044
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 917071
rule: 917027
modified:
  W3 CDTF: Fri Jun 25 14:45:18 BST 2010
parameter: 917046
parameter: 917048

611539
type: SBMLUnitsDef
unit: 611551
name: first_order_rate_constant

611551
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

917055
type: Parameter
constant: false
value: NaN
name: Km1_METH

611466
type: SBMLUnitsDef
unit: 611478
name: hour

611478
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

917034
type: Parameter
constant: false
value: 53.5
name: Met

917036
type: Parameter
constant: false
value: 137.6
name: AdoMet

917062
type: Parameter
constant: true
value: 0.1
name: Km_Hcy_MS

917040
type: Parameter
constant: true
value: 561.0
name: V_MATImax

611430
type: SBMLUnitsDef
unit: 611454
unit: 611442
name: per_micromolar

611454
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

611442
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

917057
type: Parameter
constant: false
value: NaN
name: V_MS

917039
type: Parameter
constant: false
value: NaN
name: V_MATI

917063
type: Parameter
constant: true
value: 25.0
name: Km_five_mTHF_MS

611564
type: SBMLUnitsDef
unit: 611600
unit: 611588
unit: 611576
name: second_order_rate_constant

611600
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

611588
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

611576
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

917043
type: Parameter
constant: true
value: 50.0
name: Ki_MATI

917051
type: Parameter
constant: true
value: 20.0
name: Ki_GNMT

917070
type: Parameter
constant: true
value: 30.0
name: beta2

917050
type: Parameter
constant: true
value: 4500.0
name: Km_GNMT

917066
type: Parameter
constant: true
value: 10.0
name: alpha2

917045
type: Parameter
constant: true
value: 22870.0
name: V_MATIIImax

611491
type: SBMLUnitsDef
unit: 611527
unit: 611515
unit: 611503
name: flux

611527
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

611515
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

611503
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

917054
type: Parameter
constant: true
value: 4521.0
name: V_METHmax

917073
type: Parameter
constant: true
value: 12.0
name: Km_BHMT

917068
type: Parameter
constant: true
value: 1.7
name: beta1

917061
type: Parameter
constant: true
value: 1.0
name: Kd_MS

917056
type: Parameter
constant: true
value: 10.0
name: Km2_METH_A

917038
type: Parameter
constant: false
value: 0.88
name: Hcy

611612
type: SBMLUnitsDef
unit: 611624
name: time

611624
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

917042
type: Parameter
constant: true
value: 41.0
name: Km_MATI

917059
type: Parameter
constant: true
value: 5.2
name: five_mTHF

917065
type: Parameter
constant: true
value: 100.0
name: alpha1

917053
type: Parameter
constant: false
value: NaN
name: V_METH

917033
type: Parameter
constant: false
value: NaN
name: Metin

917072
type: Parameter
constant: true
value: 2500.0
name: V_BHMTmax

917012
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

917067
type: Parameter
constant: false
value: NaN
name: V_CBS

917047
type: Parameter
constant: true
value: 21.1
name: Km2_MATIII

917049
type: Parameter
constant: true
value: 10600.0
name: V_GNMTmax

917060
type: Parameter
constant: true
value: 500.0
name: V_MSmax

917037
type: Parameter
constant: false
value: 13.2
name: AdoHcy

611393
type: SBMLUnitsDef
unit: 611417
unit: 611405
name: micromolar

611417
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

611405
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

917064
type: Parameter
constant: false
value: NaN
name: V_AH

917044
type: Parameter
constant: false
value: NaN
name: V_MATIII

917071
type: Parameter
constant: false
value: NaN
name: V_BHMT

917046
type: Parameter
constant: false
value: NaN
name: Km1_MATIII

917048
type: Parameter
constant: false
value: NaN
name: V_GNMT