MODEL1006230086
type: SBMLModel
is described by: http://identifiers.org/pubmed/17251133
parameter: 705328
units def: 585211
notes: This a model from the article: Dynamics of killer T cell inflation in viral infections. Wodarz D, Sierro S, Klenerman P. J R Soc Interface 2007 Jun 22;4(14):533-43 17251133 , Abstract: Upon acute viral infection, a typical cytotoxic T lymphocyte (CTL) response is characterized by a phase of expansion and contraction after which it settles at a relatively stable memory level. Recently, experimental data from mice infected with murine cytomegalovirus (MCMV) showed different and unusual dynamics. After acute infection had resolved, some antigen specific CTL started to expand over time despite the fact that no replicative virus was detectable. This phenomenon has been termed as "CTL memory inflation". In order to examine the dynamics of this system further, we developed a mathematical model analysing the impact of innate and adaptive immune responses. According to this model, a potentially important contributor to CTL inflation is competition between the specific CTL response and an innate natural killer (NK) cell response. Inflation occurs most readily if the NK cell response is more efficient than the CTL at reducing virus load during acute infection, but thereafter maintains a chronic virus load which is sufficient to induce CTL proliferation. The model further suggests that weaker NK cell mediated protection can correlate with more pronounced CTL inflation dynamics over time. We present experimental data from mice infected with MCMV which are consistent with the theoretical predictions. This model provides valuable information and may help to explain the inflation of CMV specific CD8+T cells seen in humans as they age. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wodarz D, Sierro S, Klenerman P. (2007) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published M…
name: Wodarz2007_CTLinflation_ModelA
parameter: 705316
parameter: 705304
compartment: 705269
parameter: 705331
rule: 705275
length unit: 493212
modified:
  W3 CDTF: Fri Jun 25 14:41:46 BST 2010
rule: 705274
parameter: 705283
rule: 705278
curated: false
parameter: 705319
rule: 705281
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
volume units: 290956
modified:
  W3 CDTF: Fri Jun 25 14:41:46 BST 2010
parameter: 705298
parameter: 705307
time units: 585211
parameter: 705295
parameter: 705292
parameter: 705286
modified:
  W3 CDTF: Fri Jun 25 14:41:46 BST 2010
rule: 705272
created:
  W3 CDTF: Fri Jun 25 14:41:46 BST 2010
units def: 585149
area units: 237671
parameter: 705322
parameter: 705313
parameter: 705310
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
units def: 585174
parameter: 705301
parameter: 705289
rule: 705273
substance units: 178797
parameter: 705325

705328
type: Parameter
constant: true
units: 585174
value: 0.1
name: phi

585174
type: SBMLUnitsDef
unit: 585198
unit: 585186
name: first_order_rate_constant

585198
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

585186
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: DIMENSIONLESS

585211
type: SBMLUnitsDef
unit: 585224
name: time

585224
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

705316
type: Parameter
constant: true
units: 585174
value: 10.0
name: lambda

705304
type: Parameter
constant: true
units: 585174
value: 0.1
name: a0

705269
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

705331
type: Parameter
constant: true
units: 585174
value: 0.01
name: eta

705283
type: Parameter
constant: true
units: 585149
value: NaN
name: time

585149
type: SBMLUnitsDef
unit: 585161
name: hour

585161
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

705319
type: Parameter
constant: true
units: 585174
value: 0.1
name: d

705298
type: Parameter
constant: false
units: dimensionless
value: 1.0
name: v

705307
type: Parameter
constant: true
units: 585174
value: 0.2
name: a1

705295
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: L

705292
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: y1

705286
type: Parameter
constant: false
units: dimensionless
value: 1.0
name: x

705322
type: Parameter
constant: true
units: 585174
value: 0.1
name: beta

705313
type: Parameter
constant: true
units: 585174
value: 1.0
name: u

705310
type: Parameter
constant: true
units: 585174
value: 1.0
name: k

705301
type: Parameter
constant: false
units: dimensionless
value: NaN
name: R0

705289
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: y0

705325
type: Parameter
constant: true
units: 585174
value: 0.5
name: gamma