MODEL1006230078
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notes: This a model from the article: The canine virtual ventricular wall: a platform for dissecting pharmacological effects on propagation and arrhythmogenesis. Benson AP, Aslanidi OV, Zhang H, Holden AV. Prog Biophys Mol Biol 2008 Jan-Apr;96(1-3):187-208 17915298 , Abstract: We have constructed computational models of canine ventricular cells and tissues, ultimately combining detailed tissue architecture and heterogeneous transmural electrophysiology. The heterogeneity is introduced by modifying the Hund-Rudy canine cell model in order to reproduce experimentally reported electrophysiological properties of endocardial, midmyocardial (M) and epicardial cells. These models are validated against experimental data for individual ionic current and action potential characteristics, and their rate dependencies. 1D and 3D heterogeneous virtual tissues are constructed, with detailed tissue architecture (anisotropy and orthotropy, due to fibre orientation and sheet structure) of the left ventricular wall wedge extracted from a diffusion tensor imaging data set. The models are used to study the effects of tissue heterogeneity and class III drugs on transmural propagation and tissue vulnerability to re-entry. We have determined relationships between the transmural dispersion of action potential duration (APD) and the vulnerable window in the 1D virtual ventricular wall, and demonstrated how changes in the transmural heterogeneity, and hence tissue vulnerability, can lead to generation of re-entry in the 3D ventricular wedge. Two class III drugs with opposite qualitative effects on transmural APD heterogeneity are considered: d-sotalol that increases transmural APD dispersion, and amiodarone that decreases it. Simulations with the 1D virtual ventricular wall show that under d-sotalol conditions the vulnerable window is substantially wider compared to amiodarone conditions, primarily in the epicardial region where unidirectional conduction block persists until the adjacent M cells are…
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ORG:
  orgname: University of Auckland
n:
  given: Catherine
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ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

W3 CDTF: Fri Jun 25 14:37:02 BST 2010

417976
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W3 CDTF: Fri Jun 25 14:37:02 BST 2010

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417835
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ORG:
  orgname: University of Auckland
n:
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W3 CDTF: Fri Jun 25 14:37:02 BST 2010

418003
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418147
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417937
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W3 CDTF: Fri Jun 25 14:37:02 BST 2010