MODEL1006230072
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name: Yanagihara1980_PacemakerActivity
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volume units: 290956
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notes: This a model from the article: Reconstruction of sino-atrial node pacemaker potential based on the voltage clamp experiments. Yanagihara K, Noma A, Irisawa H. Jpn J Physiol 1980;30(6):841-57 7265560 , Abstract: The pacemaker activity of the S-A node cell was explained by reconstructing the pacemaker potential using a Hodgkin-Huxley type mathematical model which was based on the reported voltage clamp data. In this model four dynamic currents, the sodium current iNa, the slow inward current, is, the potassium current, iK, and the hyperpolarization-activated current, ih, in addition to a time-dependent leak current, i1 were included. The model simulated the spontaneous action potential the current voltage relationship, and the voltage clamp experiment in normal Tyrode solution of the rabbit S-A node. Furthermore, the changes of activity induced by the potassium current blocker Ba2+, by applying constant current, acetylcholine, and epinephrine were also reconstructed. It was strongly suggested that the pacemaker depolarization in the S-A node cell is mainly due to a gradual increase of iS during diastole, and that the contribution of iK is much less compared to the potassium current iK2 in the Purkinje fiber pacemaker depolarization. The rising phase of the action potential was due to iS and the plateau phase is determined by both the inactivation of iS and activation of iK. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Yanagihara K, Noma A, Irisawa H. (1980) - version=1.0 The original CellML model was created by: Penny Noble penny.noble@dpag.ox.ac.uk The University of Oxford This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Ple…
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is described by: http://identifiers.org/pubmed/7265560
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W3 CDTF: Thu Feb 02 13:31:12 GMT 2012

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W3 CDTF: Thu Feb 02 17:46:35 GMT 2012

ORG:
  orgname: Department of Physiology, Anatomy & Genetics, University of Oxford
n:
  given: Penny
  family: Noble

W3 CDTF: Thu Feb 02 17:46:35 GMT 2012

ORG:
  orgname: Department of Physiology, Anatomy & Genetics, University of Oxford
n:
  given: Penny
  family: Noble

W3 CDTF: Thu Feb 02 17:46:35 GMT 2012

ORG:
  orgname: The University of Oxford
n:
  given: Penny
  family: Noble