MODEL1006230062
type: SBMLModel
modified:
  W3 CDTF: Fri Jun 25 14:23:24 BST 2010
modified:
  W3 CDTF: Fri Jun 25 14:23:24 BST 2010
rule: 603192
volume units: 290956
created:
  W3 CDTF: Fri Jun 25 14:23:24 BST 2010
parameter: 603222
units def: 483731
units def: 483621
modified:
  W3 CDTF: Fri Jun 25 14:23:24 BST 2010
parameter: 603213
substance units: 178797
parameter: 603204
units def: 483671
rule: 603183
name: Wodarz1999_CTLmemoryresponse_HIV
parameter: 603234
rule: 603177
compartment: 603172
parameter: 603240
parameter: 603197
parameter: 603207
parameter: 603231
units def: 483695
parameter: 603225
parameter: 603228
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
units def: 483767
parameter: 603210
units def: 483804
rule: 603186
units def: 483597
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 603195
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 603201
rule: 603189
rule: 603180
area units: 291053
notes: This a model from the article: Specific therapy regimes could lead to long-term immunological control of HIV. Wodarz D, Nowak MA. Proc Natl Acad Sci U S A 1999 Dec 7;96(25):14464-9 10588728 , Abstract: We use mathematical models to study the relationship between HIV and the immune system during the natural course of infection and in the context of different antiviral treatment regimes. The models suggest that an efficient cytotoxic T lymphocyte (CTL) memory response is required to control the virus. We define CTL memory as long-term persistence of CTL precursors in the absence of antigen. Infection and depletion of CD4(+) T helper cells interfere with CTL memory generation, resulting in persistent viral replication and disease progression. We find that antiviral drug therapy during primary infection can enable the development of CTL memory. In chronically infected patients, specific treatment schedules, either including deliberate drug holidays or antigenic boosts of the immune system, can lead to a re-establishment of CTL memory. Whether such treatment regimes would lead to long-term immunologic control deserves investigation under carefully controlled conditions. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wodarz D, Nowak MA. (1999) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a …
units def: 483646
parameter: 603198
curated: false
is described by: http://identifiers.org/pubmed/10588728
parameter: 603216
parameter: 603219
length unit: 076409
parameter: 603237
units def: 483572
time units: 483804

603222
type: Parameter
constant: false
value: 0.0
name: z

483731
type: SBMLUnitsDef
unit: 483755
unit: 483743
name: mm3_per_day

483755
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND

483743
type: SBMLUnit
exponent: 3.0
scale: -3
multipler: 1.0
kind: METRE

483621
type: SBMLUnitsDef
unit: 483634
name: hour

483634
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

603213
type: Parameter
constant: false
value: 0.001
name: w

603204
type: Parameter
constant: false
value: 0.1
name: y

483671
type: SBMLUnitsDef
unit: 483683
name: per_day

483683
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND

603234
type: Parameter
constant: true
value: 0.5
name: q

603172
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

603240
type: Parameter
constant: false
value: NaN
name: s

603197
type: Parameter
constant: false
value: 10.0
name: x

603207
type: Parameter
constant: true
value: 0.2
name: a

603231
type: Parameter
constant: true
value: 1.0
name: p

483695
type: SBMLUnitsDef
unit: 483719
unit: 483707
name: per_mm3_per_day

483719
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND

483707
type: SBMLUnit
exponent: -3.0
scale: -3
multipler: 1.0
kind: METRE

603225
type: Parameter
constant: true
value: 0.1
name: h

603228
type: Parameter
constant: true
value: 0.5
name: beta

483767
type: SBMLUnitsDef
unit: 483792
unit: 483780
name: mm3_mm3_per_day

483792
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 86400.0
kind: SECOND

483780
type: SBMLUnit
exponent: 6.0
scale: -3
multipler: 1.0
kind: METRE

603210
type: Parameter
constant: false
value: NaN
name: log_y

483804
type: SBMLUnitsDef
unit: 483816
name: time

483816
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 86400.0
kind: SECOND

483597
type: SBMLUnitsDef
unit: 483609
name: per_mm3

483609
type: SBMLUnit
exponent: -3.0
scale: -3
multipler: 1.0
kind: METRE

603201
type: Parameter
constant: true
value: 0.1
name: d

483646
type: SBMLUnitsDef
unit: 483658
name: day

483658
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 86400.0
kind: SECOND

603198
type: Parameter
constant: true
value: 1.0
name: lamda

603216
type: Parameter
constant: true
value: 0.01
name: b

603219
type: Parameter
constant: false
value: NaN
name: log_w

603237
type: Parameter
constant: true
value: 0.1
name: c

483572
type: SBMLUnitsDef
unit: 483584
name: mm3

483584
type: SBMLUnit
exponent: 3.0
scale: -3
multipler: 1.0
kind: METRE