MODEL1006230046
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creator:
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    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
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is described by: http://identifiers.org/pubmed/12208611
modified:
  W3 CDTF: Fri Jun 25 14:12:54 BST 2010
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created:
  W3 CDTF: Fri Jun 25 14:12:54 BST 2010
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name: Webb2002_FasFasLsystem_Tumour
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modified:
  W3 CDTF: Fri Jun 25 14:12:54 BST 2010
units def: 416361
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  W3 CDTF: Fri Jun 25 14:12:54 BST 2010
parameter: 972875
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notes: This a model from the article: Cells behaving badly: a theoretical model for the Fas/FasL system in tumour immunology. Webb SD, Sherratt JA, Fish RG. Math Biosci 2002 Sep-Oct;179(2):113-29 12208611 , Abstract: One proposed mechanism of tumour escape from immune surveillance is tumour up-regulation of the cell surface ligand FasL, which can lead to apoptosis of Fas receptor (Fas) positive lymphocytes. Based upon this 'counterattack', we have developed a mathematical model involving tumour cell-lymphocyte interaction, cell surface expression of Fas/FasL, and their secreted soluble forms. The model predicts that (a) the production of soluble forms of Fas and FasL will lead to the down-regulation of the immune response; (b) matrix metalloproteinase (MMP) inactivation should lead to increased membrane FasL and result in a higher rate of Fas-mediated apoptosis for lymphocytes than for tumour cells. Recent studies on cancer patients lend support for these predictions. The clinical implications are two-fold. Firstly, the use of broad spectrum MMP inhibitors as anti-angiogenic agents may be compromised by their adverse effect on tumour FasL up-regulation. Also, Fas/FasL interactions may have an impact on the outcome of numerous ongoing immunotherapeutic trials since the final common pathway of all these approaches is the transduction of death signals within the tumour cell. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Webb SD, Sherratt JA, Fish RG. (2002) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please re…
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creator:
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    family: Lloyd
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