MODEL1006230039
type: SBMLModel
parameter: 221512
volume units: 290956
parameter: 221561
parameter: 221541
parameter: 221553
parameter: 221517
parameter: 221544
parameter: 221556
rule: 221477
units def: 392448
rule: 221480
parameter: 221531
parameter: 221563
rule: 221474
rule: 221488
parameter: 221525
parameter: 221537
compartment: 221461
parameter: 221549
parameter: 221508
parameter: 221497
units def: 392487
rule: 221464
parameter: 221535
parameter: 221520
parameter: 221547
units def: 392409
parameter: 221559
rule: 221471
parameter: 221514
parameter: 221490
parameter: 221506
rule: 221468
is described by: http://identifiers.org/pubmed/12782119
notes: This a model from the article: Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation. Lemon G, Gibson WG, Bennett MR. J Theor Biol 2003 Jul 7;223(1):93-111 12782119 , Abstract: A mathematical account is given of the processes governing the time courses of calcium ions (Ca2+), inositol 1,4,5-trisphosphate (IP(3)) and phosphatidylinositol 4,5-bisphosphate (PIP(2)) in single cells following the application of external agonist to metabotropic receptors. A model is constructed that incorporates the regulation of metabotropic receptor activity, the G-protein cascade and the Ca2+ dynamics in the cytosol. It is subsequently used to reproduce observations on the extent of desensitization and sequestration of the P(2)Y(2) receptor following its activation by uridine triphosphate (UTP). The theory predicts the dependence on agonist concentration of the change in the number of receptors in the membrane as well as the time course of disappearance of receptors from the plasmalemma, upon exposure to agonist. In addition, the extent of activation and desensitization of the receptor, using the calcium transients in cells initiated by exposure to agonist, is also predicted. Model predictions show the significance of membrane PIP(2) depletion and resupply on the time course of IP(3) and Ca2+ levels. Results of the modelling also reveal the importance of receptor recycling and PIP(2) resupply for maintaining Ca2+ and IP(3) levels during sustained application of agonist. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Lemon G, Gibson WG, Bennett MR. (2003) - version=1.0 The original CellML model was created by: Wei Liu wliu052@aucklanduni.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 …
parameter: 221546
parameter: 221558
parameter: 221540
parameter: 221552
parameter: 221496
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parameter: 221565
parameter: 221526
parameter: 221555
parameter: 221522
parameter: 221550
parameter: 221494
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parameter: 221562
units def: 392513
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name: Lemon2003_Ca2Dynamics
parameter: 221543
time units: 379353
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curated: false
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parameter: 221523

221512
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value: 2.781E-5
name: alpha

221561
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value: NaN
name: m_infinit

221541
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value: 1000.0
name: L

221553
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name: C

221517
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constant: true
value: 0.13
name: d_1

221544
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name: RS_p

221556
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221531
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221461
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221549
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221508
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221520
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221490
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221506
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name: PIP_2_T

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221496
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name: epsilon_r

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name: d_5

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221494
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221502
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221528
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name: B_ER

221519
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221491
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W3 CDTF: Fri Jun 25 13:43:43 BST 2010

ORG:
  orgname: The University of Auckland
n:
  given: Wei
  family: Liu

W3 CDTF: Fri Jun 25 13:43:43 BST 2010

W3 CDTF: Fri Jun 25 13:43:43 BST 2010

ORG:
  orgname: The University of Auckland
n:
  given: Wei
  family: Liu

ORG:
  orgname: The University of Auckland
n:
  given: Wei
  family: Liu

W3 CDTF: Fri Jun 25 13:43:43 BST 2010