MODEL1006230037
type: SBMLModel
parameter: 178881
parameter: 178857
rule: 178812
parameter: 178874
parameter: 178869
parameter: 178837
parameter: 178886
modified:
  W3 CDTF: Fri Jun 25 13:43:00 BST 2010
parameter: 178849
parameter: 178878
notes: This a model from the article: A mathematical model of the outer medullary collecting duct of the rat. Weinstein AM. Am J Physiol Renal Physiol 2000 Jul;279(1):F24-45 10894785 , Abstract: A mathematical model of the outer medullary collecting duct (OMCD) has been developed, consisting of alpha-intercalated cells and a paracellular pathway, and which includes Na(+), K(+), Cl(-), HCO(3)(-), CO(2), H(2)CO(3), phosphate, ammonia, and urea. Proton secretion across the luminal cell membrane is mediated by both H(+)-ATPase and H-K-ATPase, with fluxes through the H-K-ATPase given by a previously developed kinetic model (Weinstein AM. Am J Physiol Renal Physiol 274: F856-F867, 1998). The flux across each ATPase is substantial, and variation in abundance of either pump can be used to control OMCD proton secretion. In comparison with the H(+)-ATPase, flux through the H-K-ATPase is relatively insensitive to changes in lumen pH, so as luminal acidification proceeds, proton secretion shifts toward this pathway. Peritubular HCO(3)(-) exit is via a conductive pathway and via the Cl(-)/HCO(3)(-) exchanger, AE1. To represent AE1, a kinetic model has been developed based on transport studies obtained at 38 degrees C in red blood cells. (Gasbjerg PK, Knauf PA, and Brahm J. J Gen Physiol 108: 565-575, 1996; Knauf PA, Gasbjerg PK, and Brahm J. J Gen Physiol 108: 577-589, 1996). Model calculations indicate that if all of the chloride entry via AE1 recycles across a peritubular chloride channel and if this channel is anything other than highly selective for chloride, then it should conduct a substantial fraction of the bicarbonate exit. Since both luminal membrane proton pumps are sensitive to small changes in cytosolic pH, variation in density of either AE1 or peritubular anion conductance can modulate OMCD proton secretory rate. With respect to the OMCD in situ, available buffer is predicted to be abundant, including delivered HCO(3)(-) and HPO(4)(2-), as well as peritubular NH(3). Thus,…
parameter: 178861
is described by: http://identifiers.org/pubmed/10894785
parameter: 178854
rule: 178797
parameter: 178841
parameter: 178870
rule: 178821
parameter: 178833
parameter: 178882
parameter: 178858
rule: 178818
units def: 383735
parameter: 178845
units def: 383760
rule: 178800
name: Weinstein2000_OMCD
rule: 178805
parameter: 178838
units def: 383699
modified:
  W3 CDTF: Fri Jun 25 13:43:00 BST 2010
rule: 178808
substance units: 178797
parameter: 178850
units def: 383626
units def: 383651
parameter: 178827
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Jonna
    family: Terkildsen
parameter: 178830
length unit: 076409
rule: 178796
rule: 178814
parameter: 178842
rule: 178791
units def: 383858
units def: 383906
parameter: 178834
rule: 178822
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Jonna
    family: Terkildsen
rule: 178817
area units: 291053
parameter: 178846
volume units: 290956
rule: 178793
units def: 383602
units def: 383542
created:
  W3 CDTF: Fri Jun 25 13:43:00 BST 2010
curated: false
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Jonna
    family: Terkildsen
parameter: 178873
units def: 383808
parameter: 178885
rule: 178825
parameter: 178828
parameter: 178877
units def: 383944
rule: 178801
units def: 383566
rule: 178813
parameter: 178829
parameter: 178862
compartment: 178787
rule: 178804
parameter: 178853
rule: 178809
parameter: 178866
rule: 178792
time units: 379353
parameter: 178865

178881
type: Parameter
constant: false
value: NaN
name: Js_bm

178857
type: Parameter
constant: false
value: NaN
name: beta_pp

178874
type: Parameter
constant: false
value: NaN
name: Jc_influx

178869
type: Parameter
constant: false
value: NaN
name: J_HCO3

178837
type: Parameter
constant: true
value: 172.0
name: K_I

178886
type: Parameter
constant: false
value: NaN
name: Js_cm

178849
type: Parameter
constant: true
value: 61.0
name: Pc_pp

178878
type: Parameter
constant: false
value: NaN
name: Ji_bm

178861
type: Parameter
constant: false
value: NaN
name: gamma_pp

178854
type: Parameter
constant: false
value: NaN
name: beta_p

178841
type: Parameter
constant: true
value: 50.0
name: Kc_pp

178870
type: Parameter
constant: false
value: NaN
name: J_Cl

178833
type: Parameter
constant: true
value: 1.0
name: x_Tmax

178882
type: Parameter
constant: false
value: NaN
name: Jo_cm

178858
type: Parameter
constant: false
value: NaN
name: gamma_p

383735
type: SBMLUnitsDef
unit: 383747
name: per_s

383747
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

178845
type: Parameter
constant: true
value: 198.0
name: Kb_pp

383760
type: SBMLUnitsDef
unit: 383796
unit: 383784
unit: 383772
name: umol_per_s_per_cm2

383796
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

383784
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

383772
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

178838
type: Parameter
constant: true
value: 50.0
name: Kc_p

383699
type: SBMLUnitsDef
unit: 383723
unit: 383711
name: cm_per_s

383723
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

383711
type: SBMLUnit
exponent: 1.0
scale: -2
multipler: 1.0
kind: METRE

178850
type: Parameter
constant: true
value: 1247.0
name: Pb_p

383626
type: SBMLUnitsDef
unit: 383638
name: cm2

383638
type: SBMLUnit
exponent: 2.0
scale: -2
multipler: 1.0
kind: METRE

383651
type: SBMLUnitsDef
unit: 383687
unit: 383675
unit: 383663
name: mM_per_s

383687
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

383675
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

383663
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

178827
type: Parameter
constant: false
value: 0.0
name: HCO3_i

178830
type: Parameter
constant: true
value: 114.0
name: Cl_e

178842
type: Parameter
constant: true
value: 198.0
name: Kb_p

383858
type: SBMLUnitsDef
unit: 383894
unit: 383882
unit: 383870
name: nmol_per_s_per_cm2

383894
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

383882
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

383870
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

383906
type: SBMLUnitsDef
unit: 383931
unit: 383918
name: mmol_per_cm2

383931
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

383918
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

178834
type: Parameter
constant: false
value: NaN
name: x_T

178846
type: Parameter
constant: true
value: 562.0
name: Pc_p

383602
type: SBMLUnitsDef
unit: 383614
name: umol

383614
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

383542
type: SBMLUnitsDef
unit: 383554
name: mmol

383554
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

178873
type: Parameter
constant: false
value: NaN
name: Jb_influx

383808
type: SBMLUnitsDef
unit: 383846
unit: 383833
unit: 383821
name: mmol_per_s_per_cm2

383846
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

383833
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

383821
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

178885
type: Parameter
constant: false
value: NaN
name: Ji_cm

178828
type: Parameter
constant: true
value: 26.0
name: HCO3_e

178877
type: Parameter
constant: false
value: NaN
name: Jo_bm

383944
type: SBMLUnitsDef
unit: 383968
unit: 383956
name: nmol_per_cm2

383968
type: SBMLUnit
exponent: -2.0
scale: -2
multipler: 1.0
kind: METRE

383956
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

383566
type: SBMLUnitsDef
unit: 383590
unit: 383578
name: mM

383590
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

383578
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

178829
type: Parameter
constant: true
value: 29.0
name: Cl_i

178862
type: Parameter
constant: false
value: NaN
name: sigma

178787
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

178853
type: Parameter
constant: true
value: 135.0
name: Pb_pp

178866
type: Parameter
constant: false
value: NaN
name: x_pp

178865
type: Parameter
constant: false
value: NaN
name: x_p

W3 CDTF: Fri Jun 25 13:43:00 BST 2010