MODEL1006230034
type: SBMLModel
parameter: 122106
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units def: 370244
parameter: 121965
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parameter: 122006
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rule: 121808
parameter: 121987
parameter: 121953
is described by: http://identifiers.org/pubmed/16837647
units def: 369542
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parameter: 121929
parameter: 122065
name: Wu2006_ATPsynthesis_SkeletalMuscle
parameter: 122083
rule: 121834
parameter: 122005
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parameter: 121941
parameter: 121931
parameter: 121977
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parameter: 122093
notes: This a model from the article: Oxidative ATP synthesis in skeletal muscle is controlled by substrate feedback. Wu F, Jeneson JA, Beard DA. Am J Physiol Cell Physiol 2007 Jan;292(1):C115-24 16837647 , Abstract: Data from (31)P-nuclear magnetic resonance spectroscopy of human forearm flexor muscle were analyzed based on a previously developed model of mitochondrial oxidative phosphorylation (PLoS Comp Bio 1: e36, 2005) to test the hypothesis that substrate level (concentrations of ADP and inorganic phosphate) represents the primary signal governing the rate of mitochondrial ATP synthesis and maintaining the cellular ATP hydrolysis potential in skeletal muscle. Model-based predictions of cytoplasmic concentrations of phosphate metabolites (ATP, ADP, and P(i)) matched data obtained from 20 healthy volunteers and indicated that as work rate is varied from rest to submaximal exercise commensurate increases in the rate of mitochondrial ATP synthesis are effected by changes in concentrations of available ADP and P(i). Additional data from patients with a defect of complex I of the respiratory chain and a patient with a deficiency in the mitochondrial adenine nucleotide translocase were also predicted the by the model by making the appropriate adjustments to the activities of the affected proteins associates with the defects, providing both further validation of the biophysical model of the control of oxidative phosphorylation and insight into the impact of these diseases on the ability of the cell to maintain its energetic state. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wu F, Jeneson JA, Beard DA. (2006) - version=1.0 The original CellML model was created by: Geoffrey Nunns gnunns1@jhu.edu The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent pos…

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369905
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122075
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122018
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units: 369905
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122070
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122137
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122121
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122129
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value: NaN
name: J_MgATP_c

121922
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units: 369321
value: 3.48E-5
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units: 370244
value: 200.0
name: X_Hle

122032
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value: NaN
name: ATP_fx

122132
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units: 369857
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name: J_AKi

122057
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units: 369321
value: 0.0065339
name: ATP_i

121921
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name: time

121967
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name: Rc_cell

122093
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122123
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122136
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122033
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369590
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122074
type: Parameter
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name: ATP_mc

122040
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122109
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122104
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size: 1.0
spatial dimensions: 3.0

122127
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122062
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121938
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121935
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units: 369542
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W3 CDTF: Fri Jun 25 13:42:04 BST 2010

122101
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122114
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122052
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121994
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122088
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121946
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122118
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122035
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122021
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370195
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370207
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369602
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369614
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122046
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369675
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122112
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value: NaN
name: J_K

122126
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units: 369857
value: NaN
name: J_MgATP_i

W3 CDTF: Fri Jun 25 13:42:04 BST 2010

122050
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value: 0.0054765
name: ADP_mx

121992
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constant: true
units: 369321
value: 0.005651
name: k_PI4

369977
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name: mole_per_second_per_l_cyto_per_molar

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name: dG_C4op

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name: dG_C4o

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122026
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name: gamma

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369530
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122054
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name: ATP_fi

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units: 369321
value: 0.0010029
name: Mg_i

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units: 369321
value: NaN
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ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

122030
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units: 369321
value: NaN
name: Cred_x

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units: 370049
value: 1.0E7
name: X_MgA

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units: 369321
value: NaN
name: k_dHatp

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value: 0.096484
name: F

121924
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units: 369760
value: 0.0
name: X_AtC

122055
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units: 369321
value: NaN
name: ADP_fi

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units: 369321
value: NaN
name: H_i

369687
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369712
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369699
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122124
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units: 369857
value: NaN
name: J_MgADP_x

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns

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value: 4.887
name: X_C3

122041
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constant: false
units: 369321
value: 0.0015723
name: NADH_x

122059
type: Parameter
constant: false
units: 369321
value: 6.5773E-5
name: ADP_i

122098
type: Parameter
constant: true
units: 369321
value: 1.0E-9
name: mincon

369408
type: SBMLUnitsDef
unit: 369432
unit: 369420
name: micromolar

369432
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: LITRE

369420
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

121969
type: Parameter
constant: true
units: dimensionless
value: 3.0
name: n_A

122095
type: Parameter
constant: false
units: 369857
value: NaN
name: J_F1

122038
type: Parameter
constant: false
units: 369321
value: 0.14661
name: K_x

122130
type: Parameter
constant: false
units: 369809
value: NaN
name: J_MgADP_c

122063
type: Parameter
constant: false
units: 369321
value: 4.8866E-5
name: ADP_mi

370146
type: SBMLUnitsDef
unit: 370183
unit: 370170
unit: 370158
name: mole_per_second_per_l_cyto_per_molar_per_molar

370183
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

370170
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

370158
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: MOLE

121971
type: Parameter
constant: true
units: 369321
value: 0.0027
name: C_tot

122068
type: Parameter
constant: false
units: 369321
value: 0.0081312
name: ATP_c

122111
type: Parameter
constant: false
units: 369857
value: NaN
name: J_KH

122086
type: Parameter
constant: false
units: 369578
value: 166.67
name: deltaPsi

122099
type: Parameter
constant: false
units: 369578
value: NaN
name: Psi_x

121957
type: Parameter
constant: false
value: NaN
name: W_x

122008
type: Parameter
constant: true
units: 370049
value: 5.651E7
name: X_KH

122081
type: Parameter
constant: false
units: 369321
value: NaN
name: ATP_fc

122134
type: Parameter
constant: false
units: 369809
value: NaN
name: J_AKc

122049
type: Parameter
constant: false
units: 369321
value: 0.0026046
name: ATP_mx

W3 CDTF: Fri Jun 25 13:42:04 BST 2010

122072
type: Parameter
constant: false
units: 369321
value: 3.0911E-7
name: AMP_c

121962
type: Parameter
constant: true
value: 0.056
name: V_mito

121975
type: Parameter
constant: true
units: 369321
value: 0.00135
name: Q_tot

122102
type: Parameter
constant: false
units: 369857
value: NaN
name: J_PI1

122012
type: Parameter
constant: true
units: 369321
value: 3.5E-6
name: k_mADP

122089
type: Parameter
constant: false
units: 369857
value: NaN
name: J_C1

W3 CDTF: Fri Jun 25 13:42:04 BST 2010

ORG:
  orgname: Auckland Bioengineering Institute, The Auckland University
n:
  given: Geoffrey
  family: Nunns