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    orgname: The University of Auckland
  n:
    given: Ethan
    family: Choi
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  W3 CDTF: Fri Jun 25 13:41:47 BST 2010
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creator:
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    orgname: The University of Auckland
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    given: Ethan
    family: Choi
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  W3 CDTF: Fri Jun 25 13:41:47 BST 2010
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  W3 CDTF: Fri Jun 25 13:41:47 BST 2010
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name: Nelson1995_HIV1therapy_DIVadministraion_ModelB
creator:
  ORG:
    orgname: The University of Auckland
  n:
    given: Ethan
    family: Choi
notes: This a model from the article: Modeling defective interfering virus therapy for AIDS: conditions for DIV survival. Nelson GW, Perelson AS. Math Biosci 1995 Feb;125(2):127-53 7881191 , Abstract: The administration of a genetically engineered defective interfering virus (DIV) that interferes with HIV-1 replication has been proposed as a therapy for HIV-1 infection and AIDS. The proposed interfering virus, which is designed to superinfect HIV-1 infected cells, carries ribozymes that cleave conserved regions in HIV-1 RNA that code for the viral envelope protein. Thus DIV infection of HIV-1 infected cells should reduce or eliminate viral production by these cells. The success of this therapeutic strategy will depend both on the intercellular interaction of DIV and HIV-1, and on the overall dynamics of virus and T cells in the body. To study these dynamical issues, we have constructed a mathematical model of the interaction of HIV-1, DIV, and CD4+ cells in vivo. The results of both mathematical analysis and numerical simulation indicate that survival of the engineered DIV purely on a peripheral blood HIV-1 infection is unlikely. However, analytical results indicate that DIV might well survive on HIV-1 infected CD4+ cells in lymphoid organs such as lymph nodes and spleen, or on other HIV-1 infected cells in these organs. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Nelson GW, Perelson AS. (1995) - version=1.0 The original CellML model was created by: Ethan Choi mcho099@aucklanduni.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In …
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is described by: http://identifiers.org/pubmed/7881191
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  W3 CDTF: Fri Jun 25 13:41:47 BST 2010
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