MODEL1006230025
type: SBMLModel
rule: 658278
rule: 658270
parameter: 658324
parameter: 658306
rule: 658272
is described by: http://identifiers.org/pubmed/17440218
parameter: 658284
units def: 324418
area units: 291053
substance units: 178797
created:
  W3 CDTF: Fri Jun 25 13:34:19 BST 2010
parameter: 658318
parameter: 658320
time units: 324623
rule: 658266
units def: 324623
parameter: 658296
units def: 324382
parameter: 658298
rule: 658268
rule: 658274
volume units: 290956
parameter: 658302
parameter: 658285
parameter: 658300
rule: 658265
modified:
  W3 CDTF: Fri Jun 25 13:34:19 BST 2010
rule: 658276
parameter: 658314
parameter: 658292
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 658316
rule: 658282
units def: 324503
parameter: 658326
parameter: 658328
parameter: 658310
parameter: 658294
curated: false
units def: 324442
units def: 324599
modified:
  W3 CDTF: Fri Jun 25 13:34:19 BST 2010
rule: 658280
parameter: 658288
units def: 324551
modified:
  W3 CDTF: Fri Jun 25 13:34:19 BST 2010
compartment: 658261
parameter: 658304
name: Phillips2007_AscendingArousalSystem_SleepWakeDynamics
units def: 324358
length unit: 455845
parameter: 658322
units def: 324466
parameter: 658308
parameter: 658312
notes: This a model from the article: A quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system. Phillips AJ, Robinson PA. J Biol Rhythms 2007 Apr;22(2):167-79 17440218 , Abstract: A quantitative, physiology-based model of the ascending arousal system is developed, using continuum neuronal population modeling, which involves averaging properties such as firing rates across neurons in each population. The model includes the ventrolateral preoptic area (VLPO), where circadian and homeostatic drives enter the system, the monoaminergic and cholinergic nuclei of the ascending arousal system, and their interconnections. The human sleep-wake cycle is governed by the activities of these nuclei, which modulate the behavioral state of the brain via diffuse neuromodulatory projections. The model parameters are not free since they correspond to physiological observables. Approximate parameter bounds are obtained by requiring consistency with physiological and behavioral measures, and the model replicates the human sleep-wake cycle, with physiologically reasonable voltages and firing rates. Mutual inhibition between the wake-promoting monoaminergic group and sleep-promoting VLPO causes ;;flip-flop'' behavior, with most time spent in 2 stable steady states corresponding to wake and sleep, with transitions between them on a timescale of a few minutes. The model predicts hysteresis in the sleep-wake cycle, with a region of bistability of the wake and sleep states. Reducing the monoaminergic-VLPO mutual inhibition results in a smaller hysteresis loop. This makes the model more prone to wake-sleep transitions in both directions and makes the states less distinguishable, as in narcolepsy. The model behavior is robust across the constrained parameter ranges, but with sufficient flexibility to describe a wide range of observed phenomena. This model was taken from the CellML repository and automatically converted to SBML. The original model wa…
parameter: 658330
parameter: 658290
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd

658324
type: Parameter
constant: true
value: 0.19
name: v_vh

658306
type: Parameter
constant: true
value: 1.0
name: v_maQao

658284
type: Parameter
constant: false
value: NaN
name: Qv

324418
type: SBMLUnitsDef
unit: 324430
name: hour

324430
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

658318
type: Parameter
constant: true
value: 1.0
name: c0

658320
type: Parameter
constant: false
value: NaN
name: omega

324623
type: SBMLUnitsDef
unit: 324636
name: time

324636
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

658296
type: Parameter
constant: true
value: 1.0
name: Vao

324382
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unit: 324394
name: mV_second

324406
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324394
type: SBMLUnit
exponent: 1.0
scale: -3
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kind: VOLT

658298
type: Parameter
constant: false
value: NaN
name: Qm

658302
type: Parameter
constant: true
value: 10.0
name: tau_m

658285
type: Parameter
constant: false
value: 0.0
name: Vv

658300
type: Parameter
constant: false
value: 0.0
name: Vm

658314
type: Parameter
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value: NaN
name: D

658292
type: Parameter
constant: false
value: NaN
name: Qa

658316
type: Parameter
constant: false
value: NaN
name: C

324503
type: SBMLUnitsDef
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unit: 324527
unit: 324515
name: nM_second

324539
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324527
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324515
type: SBMLUnit
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scale: -9
multipler: 1.0
kind: MOLE

658326
type: Parameter
constant: true
value: 100.0
name: Qmax

658328
type: Parameter
constant: true
value: 10.0
name: theta

658310
type: Parameter
constant: true
value: 10.8
name: chi

658294
type: Parameter
constant: false
value: NaN
name: Va

324442
type: SBMLUnitsDef
unit: 324454
name: per_hour

324454
type: SBMLUnit
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scale: 0
multipler: 3600.0
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name: per_second

324611
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

658288
type: Parameter
constant: true
value: 10.0
name: tau_v

324551
type: SBMLUnitsDef
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name: mV_per_nM

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658261
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units: litre
size: 1.0
spatial dimensions: 3.0

658304
type: Parameter
constant: true
value: -1.9
name: v_mv

324358
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unit: 324370
name: mV

324370
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exponent: 1.0
scale: -3
multipler: 1.0
kind: VOLT

658322
type: Parameter
constant: true
value: -6.3
name: v_vc

324466
type: SBMLUnitsDef
unit: 324491
unit: 324479
name: nM

324491
type: SBMLUnit
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kind: LITRE

324479
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: MOLE

658308
type: Parameter
constant: false
value: 15.0
name: H

658312
type: Parameter
constant: true
value: 3.6
name: mu

658330
type: Parameter
constant: true
value: 3.0
name: sigma

658290
type: Parameter
constant: true
value: -1.9
name: v_vm