MODEL1006230023
type: SBMLModel
rule: 604952
parameter: 604965
rule: 604959
parameter: 604986
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
modified:
  W3 CDTF: Fri Jun 25 13:33:25 BST 2010
parameter: 605007
modified:
  W3 CDTF: Fri Jun 25 13:33:25 BST 2010
rule: 604944
is described by: http://identifiers.org/pubmed/19414452
parameter: 604980
units def: 314831
units def: 314699
parameter: 604971
parameter: 604989
rule: 604955
length unit: 455845
units def: 314759
parameter: 604996
rule: 604940
compartment: 604936
parameter: 604961
parameter: 604999
parameter: 604962
rule: 604945
parameter: 604995
rule: 604951
modified:
  W3 CDTF: Fri Jun 25 13:33:25 BST 2010
units def: 314663
area units: 291053
units def: 314783
units def: 314880
time units: 314880
volume units: 290956
substance units: 178797
parameter: 604992
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
parameter: 605006
name: Koivumaki2009_SERCAATPase_Standalone
rule: 604941
notes: This a model from the article: Modelling sarcoplasmic reticulum calcium ATPase and its regulation in cardiac myocytes. Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. Philos Transact A Math Phys Eng Sci 2009 Jun 13;367(1896):2181-202 19414452 , Abstract: When developing large-scale mathematical models of physiology, some reduction in complexity is necessarily required to maintain computational efficiency. A prime example of such an intricate cell is the cardiac myocyte. For the predictive power of the cardiomyocyte models, it is vital to accurately describe the calcium transport mechanisms, since they essentially link the electrical activation to contractility. The removal of calcium from the cytoplasm takes place mainly by the Na(+)/Ca(2+) exchanger, and the sarcoplasmic reticulum Ca(2+) ATPase (SERCA). In the present study, we review the properties of SERCA, its frequency-dependent and beta-adrenergic regulation, and the approaches of mathematical modelling that have been used to investigate its function. Furthermore, we present novel theoretical considerations that might prove useful for the elucidation of the role of SERCA in cardiac function, achieving a reduction in model complexity, but at the same time retaining the central aspects of its function. Our results indicate that to faithfully predict the physiological properties of SERCA, we should take into account the calcium-buffering effect and reversible function of the pump. This 'uncomplicated' modelling approach could be useful to other similar transport mechanisms as well. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Koivumaki JT, Takalo J, Korhonen T, Tavi P, Weckstrom M. (2009) - version=1.0 The original CellML model was created by: Geoffrey Nunns gnunns1@jhu.edu The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) …
parameter: 605010
creator:
  ORG:
    orgname: Auckland Bioengineering Institute, The Auckland University
  n:
    given: Geoffrey
    family: Nunns
parameter: 604977
rule: 604958
created:
  W3 CDTF: Fri Jun 25 13:33:25 BST 2010
parameter: 604983
parameter: 604968
parameter: 605003
parameter: 604974
curated: false
parameter: 605002
units def: 314735
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604965
type: Parameter
constant: true
value: 0.0
name: CaMKII_reg

604986
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constant: false
value: NaN
name: EC_50_fwd

605007
type: Parameter
constant: false
value: NaN
name: J_serca_sr

604980
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constant: true
value: 2500.0
name: Kmr_PLBKO

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314711
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604971
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name: PSR

604989
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604996
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604936
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604961
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name: Ca_cyt

604999
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604962
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name: Ca_NSR

604995
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name: Kmr_PLB

604968
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name: SERCA_TOT

605003
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name: br_serca_sr

604974
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name: Kmf_PLBKO

605002
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