MODEL1006230022
type: SBMLModel
volume units: 290956
substance units: 178797
units def: 310518
modified:
  W3 CDTF: Wed Mar 16 15:21:53 GMT 2011
units def: 310674
curated: false
modified:
  W3 CDTF: Wed Mar 16 15:21:53 GMT 2011
rule: 583127
units def: 310626
parameter: 583175
parameter: 583176
rule: 583119
parameter: 583163
parameter: 583153
parameter: 583154
compartment: 583114
parameter: 583148
rule: 583122
rule: 583132
modified:
  W3 CDTF: Wed Mar 16 15:21:53 GMT 2011
rule: 583138
created:
  W3 CDTF: Fri Jun 25 13:33:04 BST 2010
notes: This a model from the article: Effect of cellular interaction on glycolytic oscillations in yeast: a theoretical investigation. Wolf J, Heinrich R. Biochem J 2000 Jan 15;345 Pt 2:321-34 10702114 , Abstract: On the basis of a detailed model of yeast glycolysis, the effect of intercellular dynamics is analysed theoretically. The model includes the main steps of anaerobic glycolysis, and the production of ethanol and glycerol. Transmembrane diffusion of acetaldehyde is included, since it has been hypothesized that this substance mediates the interaction. Depending on the kinetic parameter, the single-cell model shows both stationary and oscillatory behaviour. This agrees with experimental data with respect to metabolite concentrations and phase shifts. The inclusion of intercellular coupling leads to a variety of dynamical modes, such as synchronous oscillations, and different kinds of asynchronous behavior. These oscillations can co-exist, leading to bi- and tri-rhythmicity. The corresponding parameter regions have been identified by a bifurcation analysis. The oscillatory dynamics of synchronized cell populations are investigated by calculating the phase responses to acetaldehyde pulses. Simulations are performed with respect to the synchronization of two subpopulations that are oscillating out of phase before mixing. The effect of the various process on synchronization is characterized quantitatively. While continuous exchange of acetaldehyde might synchronize the oscillations for appropriate sets of parameter values, the calculated synchronization time is longer than that observed experimentally. It is concluded either that addition to the transmembrane exchange of acetaldehyde, other processes may contribute to intercellular coupling, or that intracellular regulator feedback plays a role in the acceleration of the synchronization. for appropriate sets of parameter values, the calculated synchronization time is longer than that observed experimentally. It is conclu…
parameter: 583178
rule: 583126
parameter: 583173
parameter: 583140
parameter: 583160
parameter: 583161
parameter: 583155
rule: 583123
units def: 310602
parameter: 583142
area units: 291053
parameter: 583158
rule: 583128
rule: 583134
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
name: Wolf2000_AnaerobicGlycolysis
parameter: 583152
parameter: 583147
rule: 583133
rule: 583137
parameter: 583171
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 583166
parameter: 583149
parameter: 583150
rule: 583120
parameter: 583144
parameter: 583174
units def: 310554
parameter: 583168
parameter: 583170
parameter: 583169
parameter: 583141
rule: 583118
parameter: 583156
rule: 583129
time units: 310674
units def: 310494
is described by: http://identifiers.org/pubmed/10702114
parameter: 583164
parameter: 583165
parameter: 583159
rule: 583121
parameter: 583143
rule: 583131
length unit: 455845
rule: 583125
rule: 583135
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
parameter: 583145

310518
type: SBMLUnitsDef
unit: 310542
unit: 310530
name: millimolar

310542
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

310530
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

310674
type: SBMLUnitsDef
unit: 310686
name: time

310686
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

310626
type: SBMLUnitsDef
unit: 310662
unit: 310650
unit: 310638
name: second_order_rate_constant

310662
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

310650
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

310638
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: MOLE

583175
type: Parameter
constant: true
value: 3.0
name: Jo

583176
type: Parameter
constant: false
value: NaN
name: J

583163
type: Parameter
constant: false
value: NaN
name: v3

583153
type: Parameter
constant: false
value: NaN
name: N1

583154
type: Parameter
constant: false
value: NaN
name: v1

583114
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

583148
type: Parameter
constant: true
value: 4.0
name: A

583178
type: Parameter
constant: true
value: 13.0
name: kappa

583173
type: Parameter
constant: false
value: NaN
name: v7

583140
type: Parameter
constant: false
value: 5.8
name: S1

583160
type: Parameter
constant: false
value: NaN
name: v2

583161
type: Parameter
constant: true
value: 6.0
name: k_2

583155
type: Parameter
constant: true
value: 0.52
name: K_I

310602
type: SBMLUnitsDef
unit: 310614
name: first_order_rate_constant

310614
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

583142
type: Parameter
constant: false
value: 0.2
name: S3

583158
type: Parameter
constant: true
value: 4.0
name: q

583152
type: Parameter
constant: true
value: 1.0
name: N

583147
type: Parameter
constant: false
value: 2.4
name: A3

583171
type: Parameter
constant: true
value: 12.0
name: k_6

583166
type: Parameter
constant: true
value: 100.0
name: k_4

583149
type: Parameter
constant: false
value: NaN
name: A2

583150
type: Parameter
constant: false
value: 0.1
name: N2

583144
type: Parameter
constant: false
value: 0.1
name: S4_ex

583174
type: Parameter
constant: true
value: 1.3
name: k

310554
type: SBMLUnitsDef
unit: 310590
unit: 310578
unit: 310566
name: flux

310590
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

310578
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

310566
type: SBMLUnit
exponent: 1.0
scale: -3
multipler: 1.0
kind: MOLE

583168
type: Parameter
constant: false
value: NaN
name: v5

583170
type: Parameter
constant: false
value: NaN
name: v6

583169
type: Parameter
constant: true
value: 1.28
name: k_5

583141
type: Parameter
constant: false
value: 0.9
name: S2

583156
type: Parameter
constant: true
value: 100.0
name: k_1

310494
type: SBMLUnitsDef
unit: 310506
name: minute

310506
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

583164
type: Parameter
constant: true
value: 16.0
name: k_3

583165
type: Parameter
constant: false
value: NaN
name: v4

583159
type: Parameter
constant: false
value: NaN
name: f_A3

583143
type: Parameter
constant: false
value: 0.2
name: S4

583145
type: Parameter
constant: true
value: 0.1
name: phi