MODEL1006230019
type: SBMLModel
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
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    orgname: University of Auckland
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    given: Catherine
    family: Lloyd
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modified:
  W3 CDTF: Fri Jun 25 13:29:24 BST 2010
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
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name: Brown1997_PlasmaMelatoninLevels
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created:
  W3 CDTF: Fri Jun 25 13:29:24 BST 2010
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modified:
  W3 CDTF: Fri Jun 25 13:29:24 BST 2010
notes: This a model from the article: A mathematical model of diurnal variations in human plasma melatonin levels. Brown EN, Choe Y, Shanahan TL, Czeisler CA. Am J Physiol 1997 Mar;272(3 Pt 1):E506-16 9124558 , Abstract: Studies in animals and humans suggest that the diurnal pattern in plasma melatonin levels is due to the hormone's rates of synthesis, circulatory infusion and clearance, circadian control of synthesis onset and offset, environmental lighting conditions, and error in the melatonin immunoassay. A two-dimensional linear differential equation model of the hormone is formulated and is used to analyze plasma melatonin levels in 18 normal healthy male subjects during a constant routine. Recently developed Bayesian statistical procedures are used to incorporate correctly the magnitude of the immunoassay error into the analysis. The estimated parameters [median (range)] were clearance half-life of 23.67 (14.79-59.93) min, synthesis onset time of 2206 (1940-0029), synthesis offset time of 0621 (0246-0817), and maximum N-acetyltransferase activity of 7.17(2.34-17.93) pmol x l(-1) x min(-1). All were in good agreement with values from previous reports. The difference between synthesis offset time and the phase of the core temperature minimum was 1 h 15 min (-4 h 38 min-2 h 43 min). The correlation between synthesis onset and the dim light melatonin onset was 0.93. Our model provides a more physiologically plausible estimate of the melatonin synthesis onset time than that given by the dim light melatonin onset and the first reliable means of estimating the phase of synthesis offset. Our analysis shows that the circadian and pharmacokinetics parameters of melatonin can be reliably estimated from a single model. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Brown EN, Choe Y, Shanahan TL, Czeisler CA. (1997) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The Univ…
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modified:
  W3 CDTF: Fri Jun 25 13:29:24 BST 2010
length unit: 335510
is described by: http://identifiers.org/pubmed/9124558

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