MODEL1006230005
type: SBMLModel
substance units: 178797
parameter: 994845
parameter: 994822
is described by: http://identifiers.org/pubmed/16864000
length unit: 335510
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
volume units: 950046
rule: 994796
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
rule: 994782
modified:
  W3 CDTF: Fri Jun 25 13:06:36 BST 2010
parameter: 994818
parameter: 994805
parameter: 994803
parameter: 994821
parameter: 994831
parameter: 994819
notes: This a model from the article: Theoretical analysis of biochemical pathways of nitric oxide release from vascular endothelial cells. Chen K, Popel AS. Free Radic Biol Med 2006 Aug 15;41(4):668-80 16864000 , Abstract: Vascular endothelium expressing endothelial nitric oxide synthase (eNOS) produces nitric oxide (NO), which has a number of important physiological functions in the microvasculature. The rate of NO production by the endothelium is a critical determinant of NO distribution in the vascular wall. We have analyzed the biochemical pathways of NO synthesis and formulated a model to estimate NO production by the microvascular endothelium under physiological conditions. The model quantifies the NO produced by eNOS based on the kinetics of NO synthesis and the availability of eNOS and its intracellular substrates. The predicted NO production from microvessels was in the range of 0.005-0.1 microM/s. This range of predicted values is in agreement with some experimental values but is much lower than other rates previously measured or estimated from experimental data with the help of mathematical modeling. Paradoxical discrepancies between the model predictions and previously reported results based on experimental measurements of NO concentration in the vicinity of the arteriolar wall suggest that NO can also be released through eNOS-independent mechanisms, such as catalysis by neuronal NOS (nNOS). We also used our model to test the sensitivity of NO production to substrate availability, eNOS concentration, and potential rate-limiting factors. The results indicated that the predicted low level of NO production can be attributed primarily to a low expression of eNOS in the microvascular endothelial cells. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Chen K, Popel AS. (2006) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model …
rule: 994780
parameter: 994837
parameter: 994847
creator:
  ORG:
    orgname: University of Auckland
  n:
    given: Catherine
    family: Lloyd
curated: false
parameter: 994850
rule: 994797
parameter: 994814
units def: 224011
rule: 994785
rule: 994794
parameter: 994846
parameter: 994829
parameter: 994839
rule: 994788
area units: area
parameter: 994810
created:
  W3 CDTF: Fri Jun 25 13:06:36 BST 2010
time units: 219790
modified:
  W3 CDTF: Fri Jun 25 13:06:36 BST 2010
modified:
  W3 CDTF: Fri Jun 25 13:06:36 BST 2010
parameter: 994842
parameter: 994806
parameter: 994804
units def: 223975
rule: 994777
parameter: 994807
rule: 994792
parameter: 994825
parameter: 994835
parameter: 994851
rule: 994786
name: Chen2006_NitricOxideRelease
rule: 994793
parameter: 994802
rule: 994800
rule: 994781
parameter: 994834
parameter: 994811
parameter: 994817
parameter: 994827
compartment: 994772
parameter: 994833
parameter: 994815
parameter: 994843
rule: 994784
parameter: 994809
units def: 224084
parameter: 994830
rule: 994790
parameter: 994838
rule: 994789
parameter: 994826
rule: 994798
parameter: 994823
parameter: 994813
parameter: 994841
units def: 224035

994845
type: Parameter
constant: true
value: 89.9
name: k_10

994822
type: Parameter
constant: false
value: 0.0
name: NOHA

994818
type: Parameter
constant: false
value: NaN
name: dNOdt

994805
type: Parameter
constant: false
value: 0.0
name: Fe3_Arg

994803
type: Parameter
constant: false
value: NaN
name: S

994821
type: Parameter
constant: false
value: 0.0
name: NO3

994831
type: Parameter
constant: true
value: 11.4
name: k_4

994819
type: Parameter
constant: false
value: 0.0
name: citrulline

994837
type: Parameter
constant: true
value: 0.91
name: k7

994847
type: Parameter
constant: true
value: 0.91
name: k12

994850
type: Parameter
constant: true
value: 0.033
name: k13

994814
type: Parameter
constant: false
value: 0.0
name: Fe3_NO

224011
type: SBMLUnitsDef
unit: 224023
name: first_order_rate_constant

224023
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

994846
type: Parameter
constant: true
value: 29.4
name: k11

994829
type: Parameter
constant: true
value: 0.91
name: k3

994839
type: Parameter
constant: true
value: 0.1
name: k_8

994810
type: Parameter
constant: false
value: 0.0
name: Fe3_NOHA

994842
type: Parameter
constant: true
value: 1.89
name: k_9

994806
type: Parameter
constant: false
value: 0.0
name: Fe2

994804
type: Parameter
constant: false
value: 0.045
name: Fe3

223975
type: SBMLUnitsDef
unit: 223999
unit: 223987
name: micromolar

223999
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

223987
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

994807
type: Parameter
constant: false
value: 0.0
name: Fe2_Arg

994825
type: Parameter
constant: true
value: 0.1
name: k1

994835
type: Parameter
constant: true
value: 12.6
name: k6

994851
type: Parameter
constant: true
value: 53.9
name: k14

994802
type: Parameter
constant: false
value: 100.0
name: Arg

994834
type: Parameter
constant: true
value: 98.0
name: k_5

994811
type: Parameter
constant: false
value: 0.0
name: Fe2_NOHA

994817
type: Parameter
constant: false
value: 0.0
name: NO

994827
type: Parameter
constant: true
value: 0.91
name: k2

994772
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

994833
type: Parameter
constant: true
value: 2.58
name: k5

994815
type: Parameter
constant: false
value: 0.0
name: Fe2_NO

994843
type: Parameter
constant: true
value: 3.33
name: k10

994809
type: Parameter
constant: false
value: 0.0
name: Fe3_O2_Arg

224084
type: SBMLUnitsDef
unit: 224120
unit: 224108
unit: 224096
name: flux

224120
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

224108
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

224096
type: SBMLUnit
exponent: 1.0
scale: -6
multipler: 1.0
kind: MOLE

994830
type: Parameter
constant: true
value: 1.89
name: k4

994838
type: Parameter
constant: true
value: 0.1
name: k8

994826
type: Parameter
constant: true
value: 0.1
name: k_1

994823
type: Parameter
constant: true
value: 172.0
name: O2

994813
type: Parameter
constant: false
value: 0.0
name: Fe3_O2_NOHA

994841
type: Parameter
constant: true
value: 11.4
name: k9

224035
type: SBMLUnitsDef
unit: 224072
unit: 224060
unit: 224047
name: second_order_rate_constant

224072
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: LITRE

224060
type: SBMLUnit
exponent: -1.0
scale: -6
multipler: 1.0
kind: MOLE

224047
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND