MODEL1006230003
type: SBMLModel
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parameter: 780104
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parameter: 780160
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area units: area
parameter: 780096
parameter: 780152
parameter: 780117
rule: 780070
parameter: 780125
parameter: 780093
parameter: 780157
parameter: 780087
parameter: 780108
parameter: 780097
rule: 780072
parameter: 780112
parameter: 780100
units def: 214654
parameter: 780132
substance units: 178797
parameter: 780176
name: Waugh2006_WoundHealing_Diabetic_ModelB
rule: 780080
curated: false
units def: 214582
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parameter: 780153
parameter: 780128
rule: 780069
units def: 215027
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parameter: 780105
units def: 214751
parameter: 780168
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parameter: 780149
time units: 215124
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parameter: 780113
parameter: 780145
parameter: 780133
units def: 214462
parameter: 780089
parameter: 780177
units def: 214991
rule: 780077
notes: This a model from the article: Modeling the effects of treating diabetic wounds with engineered skin substitutes. Waugh HV, Sherratt JA. Wound Repair Regen 2007 Jul-Aug;15(4):556-65 17650100 , Abstract: In this paper, a novel mathematical model of wound healing in both normal and diabetic cases is presented, focusing upon the effects of adding two currently available commercial engineered skin substitute therapies to the wound (Apligraf) and Dermagraft). Our work extends a previously developed model, which considers inflammatory and repair macrophage dynamics in normal and diabetic wound healing. Here, we extend the model to include equations for platelet-derived growth factor concentration, fibroblast density, collagen density, and hyaluronan concentration. This enables us to examine the variation of these components in both normal and diabetic wound healing cases, and to model the treatment protocols of these therapies. Within the context of our model, we find that the key component to successful healing in diabetic wounds is hyaluronan and that the therapies work by increasing the amount of hyaluronan available in the wound environment. The time-to-healing results correlate with those observed in clinical trials and the model goes some way to establishing an understanding of why diabetic wounds do not heal, and how these treatments affect the diabetic wound environment to promote wound closure. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Waugh HV, Sherratt JA. (2007) - version=1.0 The original CellML model was created by: Catherine Lloyd c.lloyd@auckland.ac.nz The University of Auckland This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public do…
parameter: 780120
parameter: 780172
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length unit: 335510
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is described by: http://identifiers.org/pubmed/17650100
parameter: 780141
units def: 214522
parameter: 780169
parameter: 780116
compartment: 780064
rule: 780076
units def: 214955
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volume units: 950046
parameter: 780124
parameter: 780140
units def: 214787
parameter: 780156
parameter: 780109

780165
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constant: true
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214690
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214654
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214666
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214558
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780125
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780093
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214486
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780157
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name: k8

780087
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780108
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780097
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name: C

214522
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780112
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name: g_C

780176
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780161
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780136
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215063
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780088
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780149
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780113
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780145
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780133
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780089
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780064
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780140
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780156
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780092
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name: T

W3 CDTF: Fri Jun 25 13:03:01 BST 2010

780101
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780121
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ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

W3 CDTF: Fri Jun 25 13:03:01 BST 2010

W3 CDTF: Fri Jun 25 13:03:01 BST 2010

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

ORG:
  orgname: University of Auckland
n:
  given: Catherine
  family: Lloyd

W3 CDTF: Fri Jun 25 13:03:01 BST 2010