MODEL0975191032
type: SBMLModel
is described by: http://identifiers.org/pubmed/18762202
species: metaid_0000025
species: metaid_0000061
reaction: metaid_0000148
reaction: metaid_0000171
reaction: metaid_0000246
reaction: metaid_0000203
units def: metaid_0000004
reaction: metaid_0000221
species: metaid_0000036
species: metaid_0000072
reaction: metaid_0000198
reaction: metaid_0000133
area units: area
reaction: metaid_0000183
reaction: metaid_0000140
reaction: metaid_0000192
reaction: metaid_0000215
species: metaid_0000022
reaction: metaid_0000127
reaction: metaid_0000131
species: metaid_0000119
reaction: metaid_0000233
reaction: metaid_0000145
reaction: metaid_0000200
reaction: metaid_0000250
species: metaid_0000039
species: metaid_0000010
curated: false
reaction: metaid_0000143
reaction: metaid_0000247
reaction: metaid_0000172
reaction: metaid_0000238
species: metaid_0000086
species: metaid_0000053
reaction: metaid_0000124
reaction: metaid_0000159
species: metaid_0000027
species: metaid_0000055
species: metaid_0000035
species: metaid_0000071
reaction: metaid_0000134
species: metaid_0000064
reaction: metaid_0000184
species: metaid_0000041
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reaction: metaid_0000175
species: metaid_0000120
reaction: metaid_0000151
species: metaid_0000043
species: metaid_0000023
reaction: metaid_0000227
species: metaid_0000052
reaction: 747727
reaction: metaid_0000139
species: metaid_0000089
reaction: metaid_0000244
reaction: metaid_0000251
reaction: metaid_0000187
reaction: metaid_0000163
reaction: metaid_0000239
reaction: metaid_0000181
reaction: metaid_0000168
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species: metaid_0000062
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reaction: metaid_0000206
units def: metaid_0000003
reaction: metaid_0000241
reaction: metaid_0000224
species: metaid_0000069
reaction: metaid_0000195
reaction: metaid_0000176
reaction: metaid_0000160
species: metaid_0000014
species: metaid_0000077
species: metaid_0000050
reaction: metaid_0000152

metaid_0000025
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0054982
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKPP_MKP

metaid_0000007
type: Compartment
constant: true
size: 1.0
spatial dimensions: 3.0
name: cell

metaid_0000061
type: Species
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substance units: mole
initial concentration: 1.4492E-4
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name: PLCb_Gq_a_GTP

metaid_0000148
type: Reaction
kinetic law: 734959
product: 734947
product: 734934
reactant: 734922
notes: releaseERKP_MEKPP
fast: false
reversible: false
name: u2

124217
type: LocalParameter
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value: 0.01
name: k60

metaid_0000004
type: SBMLUnitsDef
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name: 1/sec

733720
type: SBMLUnit
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scale: 0
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734947
type: SpeciesReference
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species: metaid_0000020

metaid_0000020
type: Species
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name: MEK_PP

734934
type: SpeciesReference
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species: metaid_0000031

metaid_0000031
type: Species
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substance units: mole
initial concentration: 0.010356
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name: ERK_P

734922
type: SpeciesReference
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species: metaid_0000019

metaid_0000019
type: Species
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substance units: mole
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name: cpxERK_MEK_PP

metaid_0000171
type: Reaction
kinetic law: 735998
product: 735986
reactant: 735974
fast: false
reversible: true
name: receptor2a_inter

124262
type: LocalParameter
units: metaid_0000004
value: 5.0E-5
name: v6r_2a

124261
type: LocalParameter
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value: 0.005
name: v6_2a

735986
type: SpeciesReference
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species: metaid_0000051

metaid_0000051
type: Species
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initial concentration: 1.0192
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name: ht2AR

735974
type: SpeciesReference
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species: metaid_0000052

metaid_0000052
type: Species
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substance units: mole
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name: ht2AR_internal

metaid_0000246
type: Reaction
kinetic law: 739472
product: 739460
product: 739448
reactant: 739436
notes: releaseGrb2_Sos
fast: false
reversible: true
name: v35_splitGrb2_Sos

124428
type: LocalParameter
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value: 0.1
name: k38r

metaid_0000003
type: SBMLUnitsDef
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unit: 733684
name: 1/(M*sec)

733708
type: SBMLUnit
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kind: SECOND

733696
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733684
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kind: LITRE

124427
type: LocalParameter
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value: 0.0015
name: k38

739460
type: SpeciesReference
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species: metaid_0000113

metaid_0000113
type: Species
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boundary condition: false
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name: Sos

739448
type: SpeciesReference
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species: metaid_0000112

metaid_0000112
type: Species
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initial concentration: 0.255
initial amount: NaN
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name: Grb2

739436
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

metaid_0000116
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
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name: Grb2_sos

metaid_0000203
type: Reaction
kinetic law: 737504
product: 737492
reactant: 737480
reactant: 737468
fast: false
reversible: true
name: DAGbindsPKC

124342
type: LocalParameter
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value: 5.99E-4
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124339
type: LocalParameter
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value: 0.1
name: k22_2a

737492
type: SpeciesReference
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species: metaid_0000068

metaid_0000068
type: Species
constant: false
boundary condition: false
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substance units: mole
initial concentration: 0.58385
initial amount: NaN
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name: PKC_DAG

737480
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000065
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.055555
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in compartment: metaid_0000007
name: DAG

737468
type: SpeciesReference
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species: metaid_0000066

metaid_0000066
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
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initial amount: NaN
in compartment: metaid_0000007
name: PKC

metaid_0000221
type: Reaction
kinetic law: 738336
product: 738324
product: 738312
reactant: 738300
notes: deactSrc
fast: false
reversible: false
name: releaseSrc

124378
type: LocalParameter
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value: 14.0
name: k31

738324
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

metaid_0000093
type: Species
constant: false
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name: Csk

738312
type: SpeciesReference
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species: metaid_0000090

metaid_0000090
type: Species
constant: false
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substance units: mole
initial concentration: 0.2
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name: Src

738300
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

metaid_0000094
type: Species
constant: false
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name: cpxCsk_Srcstar

metaid_0000036
type: Species
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substance units: mole
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name: MEK_P

metaid_0000072
type: Species
constant: false
boundary condition: false
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substance units: mole
initial concentration: 1.9064E-4
initial amount: NaN
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name: PKC_Ca_AA

metaid_0000198
type: Reaction
kinetic law: 737237
modifier: 737225
product: 737213
reactant: 737201
fast: false
reversible: false
name: PKC_DAG_AAregu_RasGEF

124328
type: LocalParameter
units: metaid_0000005
value: 3.33
name: Km35_2a

metaid_0000005
type: SBMLUnitsDef
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unit: 733732
name: M

733744
type: SBMLUnit
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scale: 0
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kind: MOLE

733732
type: SBMLUnit
exponent: -1.0
scale: 0
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kind: LITRE

124325
type: LocalParameter
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name: k35_2a

metaid_0000081
type: Species
constant: false
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substance units: mole
initial concentration: 0.31811
initial amount: NaN
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name: PKC_DAG_AAactive

737213
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

metaid_0000076
type: Species
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boundary condition: false
has only substance units: false
substance units: mole
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initial amount: NaN
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name: RasGEF_star

737201
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000075
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.072743
initial amount: NaN
in compartment: metaid_0000007
name: RasGEF

metaid_0000133
type: Reaction
kinetic law: 734251
product: 734239
reactant: 734227
reactant: 734215
notes: Rafstarbinds_MEKP
fast: false
reversible: true
name: v46_88

124192
type: LocalParameter
units: metaid_0000004
value: 0.42
name: k49r

124189
type: LocalParameter
units: metaid_0000003
value: 3.28
name: k49

734239
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000033

metaid_0000033
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.017627
initial amount: NaN
in compartment: metaid_0000007
name: cpxMEKP_Rafstar

734227
type: SpeciesReference
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species: metaid_0000036

734215
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

metaid_0000039
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.057628
initial amount: NaN
in compartment: metaid_0000007
name: Rafstar

metaid_0000183
type: Reaction
kinetic law: 736573
product: 736561
reactant: 736549
reactant: 736537
fast: false
reversible: true
name: AA_binds_PKC

124290
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k61r_2a

124289
type: LocalParameter
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value: 1.2E-4
name: k61_2a

736561
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000073

metaid_0000073
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 4.5732E-4
initial amount: NaN
in compartment: metaid_0000007
name: PKC_AA

736549
type: SpeciesReference
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species: metaid_0000066

736537
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

metaid_0000071
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 6.0539
initial amount: NaN
in compartment: metaid_0000007
name: AA

metaid_0000140
type: Reaction
kinetic law: 734569
product: 734556
reactant: 734543
notes: formERK_MKPPP
fast: false
reversible: false
name: w5

124205
type: LocalParameter
units: metaid_0000004
value: 0.5
name: k69

734556
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000021
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.066479
initial amount: NaN
in compartment: metaid_0000007
name: cpxERK_MKP_PP

734543
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

metaid_0000011
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0018979
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKP_MKP_PPstar

metaid_0000192
type: Reaction
kinetic law: 736948
modifier: 736936
product: 736924
reactant: 736912
fast: false
reversible: false
name: PKC_AA_actRasGAP

124312
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k40_2a

124309
type: LocalParameter
units: metaid_0000005
value: 3.33
name: Km40_2a

736924
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

metaid_0000077
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0015858
initial amount: NaN
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name: RasGAP_star

736912
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000043
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 4.1421E-4
initial amount: NaN
in compartment: metaid_0000007
name: RasGAP

metaid_0000215
type: Reaction
kinetic law: 738048
product: 738036
product: 738024
reactant: 738012
notes: releasePI3Kstar_betagamma
fast: false
reversible: false
name: release_activePI3K

124369
type: LocalParameter
units: metaid_0000004
value: 0.25
name: k23

738036
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

metaid_0000105
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Gi_betagamma

738024
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

metaid_0000087
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: PI3Kstar

738012
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000086

metaid_0000086
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Gi_br_PI3K

metaid_0000022
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.48458
initial amount: NaN
in compartment: metaid_0000007
name: MKP

metaid_0000127
type: Reaction
kinetic law: 733962
product: 733950
product: 733938
reactant: 733926
notes: releasePP2A_Rafstar
fast: false
reversible: false
name: releaseRafstarstar

124178
type: LocalParameter
units: metaid_0000004
value: 6.0
name: k54

733950
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

733938
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

metaid_0000035
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.15859
initial amount: NaN
in compartment: metaid_0000007
name: PP2A

733926
type: SpeciesReference
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species: metaid_0000014

metaid_0000014
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 2.2131E-5
initial amount: NaN
in compartment: metaid_0000007
name: cpxRafstarstar_PP2A

metaid_0000131
type: Reaction
kinetic law: 734154
product: 734142
product: 734130
reactant: 734118
notes: basalGi_a_GTPsplit
fast: false
reversible: false
name: basal_Gq_a_GTP_split_rx

124186
type: LocalParameter
units: metaid_0000004
value: 0.01
name: k8_2a

734142
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

metaid_0000059
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0027739
initial amount: NaN
in compartment: metaid_0000007
name: Gq_a_GDP

734130
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000046
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 618.69
initial amount: NaN
in compartment: metaid_0000007
name: Pi

734118
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

metaid_0000057
type: Species
constant: false
boundary condition: false
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substance units: mole
initial concentration: 6.4172E-4
initial amount: NaN
in compartment: metaid_0000007
name: Gq_a_GTP

metaid_0000119
type: Species
constant: false
boundary condition: false
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substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Grb2_sos_P

metaid_0000233
type: Reaction
kinetic law: 738819
product: 738807
reactant: 738795
reactant: 738783
notes: cpxAR1Abinds_Gi
fast: false
reversible: true
name: HRbindsGitrimer_GDP

124405
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k4r

124404
type: LocalParameter
units: metaid_0000003
value: 13.33
name: k4

738807
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000104

metaid_0000104
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_R1A_Gi

738795
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000102

metaid_0000102
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.0
initial amount: NaN
in compartment: metaid_0000007
name: Gitrimer

738783
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000101

metaid_0000101
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_HT1AR

metaid_0000145
type: Reaction
kinetic law: 734811
product: 734799
reactant: 734787
reactant: 734774
fast: false
reversible: true
name: Rafstar_bindsERKPP

124213
type: LocalParameter
units: metaid_0000004
value: 40.0
name: k75r

124212
type: LocalParameter
units: metaid_0000003
value: 1.95
name: k75

734799
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

metaid_0000015
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 2.2131E-5
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKPP_Rafstar

734787
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

734774
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

metaid_0000017
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0090591
initial amount: NaN
in compartment: metaid_0000007
name: ERK_PP

metaid_0000200
type: Reaction
kinetic law: 737334
modifier: 737322
product: 737310
reactant: 737298
fast: false
reversible: false
name: AAfrom_PIP2PLA2

124334
type: LocalParameter
units: metaid_0000005
value: 20.0
name: Km84_2a

124331
type: LocalParameter
units: metaid_0000004
value: 11.04
name: k84_2a

metaid_0000078
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.39671
initial amount: NaN
in compartment: metaid_0000007
name: PIP2_PLA2

737310
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

737298
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000070
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 23.496
initial amount: NaN
in compartment: metaid_0000007
name: APC

metaid_0000250
type: Reaction
kinetic law: 739677
product: 739665
reactant: 739653
reactant: 739640
notes: RasGDPbinds_Shrcstar_Grb2_Sos
fast: false
reversible: true
name: RasGDPbinds_ShcstarGrb2Sos

124438
type: LocalParameter
units: metaid_0000004
value: 0.08
name: k42r

124437
type: LocalParameter
units: metaid_0000003
value: 0.2
name: k42

739665
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

metaid_0000118
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxRasGDP_Shcstar_Grb2_Sos

739653
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

metaid_0000044
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.076348
initial amount: NaN
in compartment: metaid_0000007
name: RasGDP

739640
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000117
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Shcstar_Grb2_Sos

metaid_0000010
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.003791
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKP_MKP_PP

metaid_0000143
type: Reaction
kinetic law: 734714
product: 734702
product: 734689
reactant: 734677
notes: releaseRaf_PP2A
fast: false
reversible: false
name: releaseRaf

124209
type: LocalParameter
units: metaid_0000004
value: 6.0
name: k52

734702
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

734689
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000041
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.030124
initial amount: NaN
in compartment: metaid_0000007
name: Raf

734677
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

metaid_0000016
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 5.8373E-4
initial amount: NaN
in compartment: metaid_0000007
name: cpxRafstar_PP2A

metaid_0000247
type: Reaction
name: Sos_PbyERK_PP
kinetic law: 739532
notes: Grb2sosP_byERKPP
reactant: 739484
modifier: 739520
product: 739508
product: 739496
fast: false
reversible: false

124430
type: LocalParameter
units: metaid_0000004
value: 1.0
name: kdd

124429
type: LocalParameter
units: metaid_0000005
value: 2.564
name: kmdd

739484
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

739508
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

metaid_0000114
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Shc_star

739496
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000172
type: Reaction
kinetic law: 736035
product: 736023
reactant: 736010
fast: false
reversible: false
name: L2sR_internal_deg

124263
type: LocalParameter
units: metaid_0000004
value: 6.67E-4
name: v62_2a

736023
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000053

metaid_0000053
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: A_2AR_i_deg

736010
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

metaid_0000054
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_2AR_internal

metaid_0000238
type: Reaction
fast: false
reactant: 739050
product: 739074
notes: RGS4deact_GiaGTP
name: dissociation_RGS_Gia_GTPcpx
product: 739062
kinetic law: 739098
product: 739086
reversible: false

739050
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000108

metaid_0000108
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxRGS4_Gi_a_GTP_1

739074
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000109

metaid_0000109
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.02
initial amount: NaN
in compartment: metaid_0000007
name: RGS4_1

739062
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000107

metaid_0000107
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Gi_a_GDP

124414
type: LocalParameter
units: metaid_0000004
value: 8.33
name: k10

739086
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000124
type: Reaction
kinetic law: 733829
product: 733817
product: 733805
reactant: 733792
notes: releaseERKP_MKPPP
fast: false
reversible: true
name: v57_w3

124174
type: LocalParameter
units: metaid_0000003
value: 10.0
name: k67r

124171
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k67

733817
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

metaid_0000030
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.027491
initial amount: NaN
in compartment: metaid_0000007
name: MKP_PP

733805
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

733792
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

metaid_0000159
type: Reaction
kinetic law: 735481
product: 735468
reactant: 735455
fast: false
reversible: true
name: intrinsicRas

124238
type: LocalParameter
units: metaid_0000004
value: 1.2E-4
name: k44r

124237
type: LocalParameter
units: metaid_0000004
value: 1.6E-4
name: k44

735468
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

metaid_0000042
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.02024
initial amount: NaN
in compartment: metaid_0000007
name: RasGTP

735455
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

metaid_0000027
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 2.5313E-7
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKPP_PLA2star

metaid_0000055
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_2AR

metaid_0000134
type: Reaction
kinetic law: 734299
product: 734287
product: 734275
reactant: 734263
notes: releasePP2A_MEKP
fast: false
reversible: false
name: v49_91

124193
type: LocalParameter
units: metaid_0000004
value: 6.0
name: k58

734287
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000036

734275
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

734263
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

metaid_0000013
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 3.0847E-4
initial amount: NaN
in compartment: metaid_0000007
name: cpxMEKPP_PP2A

metaid_0000064
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.21952
initial amount: NaN
in compartment: metaid_0000007
name: IP3

metaid_0000184
type: Reaction
kinetic law: 736621
product: 736609
reactant: 736597
reactant: 736585
fast: false
reversible: true
name: PIP2_binds_PLA2_Ca

124294
type: LocalParameter
units: metaid_0000004
value: 0.012
name: k65r_2a

124291
type: LocalParameter
units: metaid_0000003
value: 0.1
name: k65_2a

736609
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000074

metaid_0000074
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0027563
initial amount: NaN
in compartment: metaid_0000007
name: PIP2_PLA2_Ca

736597
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

metaid_0000024
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.2445E-4
initial amount: NaN
in compartment: metaid_0000007
name: PLA2_Ca

736585
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000045
type: Species
constant: false
boundary condition: true
has only substance units: false
substance units: mole
initial concentration: 2.6578
initial amount: NaN
in compartment: metaid_0000007
name: PIP2

metaid_0000082
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 83332.0
initial amount: NaN
in compartment: metaid_0000007
name: PA

metaid_0000175
type: Reaction
kinetic law: 736185
product: 736172
reactant: 736159
reactant: 736146
fast: false
reversible: true
name: PLCb_binds_Gq_a_GTP

124268
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k11r_2a

124267
type: LocalParameter
units: metaid_0000003
value: 2.52
name: k11_2a

736172
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000061

736159
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

metaid_0000060
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.090022
initial amount: NaN
in compartment: metaid_0000007
name: PLCb

736146
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

metaid_0000120
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: Ketanserin

metaid_0000151
type: Reaction
kinetic law: 735104
product: 735092
reactant: 735080
reactant: 735068
notes: PLA2binds_Ca
fast: false
reversible: true
name: PLA2_binds_Ca

124225
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k74r

124224
type: LocalParameter
units: metaid_0000003
value: 1.0
name: k74

735092
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000024

735080
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000028
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.034739
initial amount: NaN
in compartment: metaid_0000007
name: Ca

735068
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

metaid_0000029
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 3.5823E-4
initial amount: NaN
in compartment: metaid_0000007
name: PLA2

metaid_0000023
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 3.1036E-5
initial amount: NaN
in compartment: metaid_0000007
name: PLA2star_Ca

metaid_0000227
type: Reaction
kinetic law: 738579
product: 738566
reactant: 738554
fast: false
reversible: true
name: receptor_interl

124390
type: LocalParameter
units: metaid_0000004
value: 5.0E-5
name: v6r

124389
type: LocalParameter
units: metaid_0000004
value: 0.005
name: v6

738566
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000100

metaid_0000100
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.6929
initial amount: NaN
in compartment: metaid_0000007
name: HT1AR

738554
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000099

metaid_0000099
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: HT1AR_internal

747727
type: Reaction
kinetic law: 739918
product: 739906
reactant: 739894
reactant: 739882
fast: false
reversible: true
name: cpxKetR_bindsGq

124449
type: LocalParameter
units: metaid_0000004
value: 1.67
name: krant_KRbindsG

124446
type: LocalParameter
units: metaid_0000003
value: 1.0
name: kant_KRbindsG

739906
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

metaid_0000122
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: cpxKetanserin_2ARGq

739894
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

metaid_0000056
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.61869
initial amount: NaN
in compartment: metaid_0000007
name: Gq_trimer

739882
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

metaid_0000121
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: cpxKetanserin_2AR

metaid_0000139
type: Reaction
kinetic law: 734530
product: 734518
product: 734506
reactant: 734493
notes: releaseERK_MKPPP
fast: false
reversible: true
name: v59_w6

124204
type: LocalParameter
units: metaid_0000003
value: 1.1
name: k70r

124203
type: LocalParameter
units: metaid_0000004
value: 0.086
name: k70

734518
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

734506
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

metaid_0000032
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.15768
initial amount: NaN
in compartment: metaid_0000007
name: ERK

734493
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000021

metaid_0000089
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: PIP3

metaid_0000244
type: Reaction
kinetic law: 739388
product: 739376
product: 739363
reactant: 739351
notes: releaseShcstar_Grb2sos
fast: false
reversible: true
name: v33_splitShc_star_Grb2_Sos

124425
type: LocalParameter
units: metaid_0000003
value: 21.0
name: k39r

124424
type: LocalParameter
units: metaid_0000004
value: 2.0
name: k39

739376
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

739363
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

739351
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

metaid_0000251
type: Reaction
kinetic law: 739725
product: 739713
product: 739701
reactant: 739689
notes: RasGTP_byShcstarGrb2Sos
fast: false
reversible: false
name: releaseRasGTPfromShc

124439
type: LocalParameter
units: metaid_0000004
value: 0.02
name: k43

739713
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

739701
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

739689
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000118

metaid_0000187
type: Reaction
kinetic law: 736742
reactant: 736730
fast: false
reversible: false
name: IP3deg

124302
type: LocalParameter
units: metaid_0000005
value: 0.16
name: IP3basal

124299
type: LocalParameter
units: metaid_0000004
value: 0.14
name: k19_2a

736730
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

metaid_0000163
type: Reaction
kinetic law: 735686
product: 735674
reactant: 735662
reactant: 735650
fast: false
reversible: false
name: Gqtrimerization

124243
type: LocalParameter
units: metaid_0000003
value: 6.0
name: k6_2a

735674
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

735662
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

metaid_0000058
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0037173
initial amount: NaN
in compartment: metaid_0000007
name: Gq_betagamma

735650
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

metaid_0000239
type: Reaction
kinetic law: 739146
product: 739134
product: 739122
reactant: 739110
notes: basalGi_a_GTPsplit
fast: false
reversible: false
name: basal_Gi_a_GTP_split_rx

124415
type: LocalParameter
units: metaid_0000004
value: 0.0667
name: k8

739134
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

739122
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000107

739110
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000106

metaid_0000106
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Gi_a_GTP

metaid_0000181
type: Reaction
kinetic law: 736477
modifier: 736465
product: 736453
reactant: 736441
fast: false
reversible: false
name: AAfrom_PLA2star_Ca

124286
type: LocalParameter
units: metaid_0000005
value: 20.0
name: Km57_2a

124283
type: LocalParameter
units: metaid_0000004
value: 120.0
name: k57_2a

736453
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

736441
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000168
type: Reaction
kinetic law: 735914
product: 735902
reactant: 735890
notes: dep_PLA2star
fast: false
reversible: false
name: dep_PLA2_star

124257
type: LocalParameter
units: metaid_0000004
value: 0.17
name: k73

735902
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

735890
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

metaid_0000026
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.489E-5
initial amount: NaN
in compartment: metaid_0000007
name: PLA2star

metaid_0000008
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.01
initial amount: NaN
in compartment: metaid_0000007
name: TCB

metaid_0000062
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0093825
initial amount: NaN
in compartment: metaid_0000007
name: PLCb_Ca

metaid_0000206
type: Reaction
kinetic law: 737625
product: 737613
reactant: 737601
fast: false
reversible: true
name: PKC_DAG_AAactive

124348
type: LocalParameter
units: metaid_0000004
value: 0.2
name: k60r_2a

124347
type: LocalParameter
units: metaid_0000004
value: 2.0
name: k60_2a

737613
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000081

737601
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

metaid_0000069
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.031811
initial amount: NaN
in compartment: metaid_0000007
name: PKC_DAG_AA

metaid_0000241
type: Reaction
kinetic law: 739242
product: 739230
reactant: 739218
reactant: 739206
notes: Grb2binds_Sos
fast: false
reversible: true
name: v17_64_SosbindsGrb2

124419
type: LocalParameter
units: metaid_0000004
value: 0.0214
name: k35r

124418
type: LocalParameter
units: metaid_0000003
value: 10.0
name: k35

739230
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

739218
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

739206
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000112

metaid_0000224
type: Reaction
kinetic law: 738469
product: 738457
reactant: 738445
notes: degPI3Kstar
fast: false
reversible: false
name: deactPI3K_star

124385
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k79

738457
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

metaid_0000085
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.16
initial amount: NaN
in compartment: metaid_0000007
name: PI3K

738445
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

metaid_0000195
type: Reaction
kinetic law: 737093
modifier: 737081
product: 737069
reactant: 737057
fast: false
reversible: false
name: PKC_Ca_DAGactive_actRasGEF

124320
type: LocalParameter
units: metaid_0000005
value: 3.33
name: Km41_2a

124317
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k41_2a

metaid_0000080
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.3507E-6
initial amount: NaN
in compartment: metaid_0000007
name: PKC_Ca_DAGactive

737069
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

737057
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000176
type: Reaction
kinetic law: 736235
product: 736223
reactant: 736211
reactant: 736199
fast: false
reversible: true
name: PLCb_binds_Ca

124272
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k12r_2a

124269
type: LocalParameter
units: metaid_0000003
value: 3.0
name: k12_2a

736223
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

736211
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000060

736199
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000160
type: Reaction
notes: RGS4deact_GiaGTP
name: dissociation_RGS_Gqa_GTPcpx
kinetic law: 735541
product: 735529
reactant: 735493
product: 735505
reversible: false
product: 735517
fast: false

124239
type: LocalParameter
units: metaid_0000004
value: 8.33
name: k10_2a

735529
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

735493
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

metaid_0000048
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 6.4168E-6
initial amount: NaN
in compartment: metaid_0000007
name: cpxRGS4_Gq_a_GTP

735505
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

metaid_0000047
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.019994
initial amount: NaN
in compartment: metaid_0000007
name: RGS4

735517
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000050
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.37759
initial amount: NaN
in compartment: metaid_0000007
name: cpx2AR_Gqtrimer

metaid_0000152
type: Reaction
kinetic law: 735152
product: 735140
product: 735128
reactant: 735116
notes: releaseRafstar_RasGTP
fast: false
reversible: false
name: releaseRafstardRasGTP

124226
type: LocalParameter
units: metaid_0000004
value: 0.125
name: k46

735140
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

735128
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

735116
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

metaid_0000040
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.023412
initial amount: NaN
in compartment: metaid_0000007
name: cpxRasGTP_Raf

metaid_0000218
type: Reaction
kinetic law: 738192
product: 738180
reactant: 738168
reactant: 738156
fast: false
reversible: true
name: Srcbinds_PIP3

124374
type: LocalParameter
units: metaid_0000004
value: 4.52
name: k26r

124373
type: LocalParameter
units: metaid_0000003
value: 1.6143
name: k26

738180
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000091
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxSrc_PIP3

738168
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000089

738156
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000090

metaid_0000170
type: Reaction
kinetic law: 735962
reactant: 735950
fast: false
reversible: false
name: ligand_deg

124260
type: LocalParameter
units: metaid_0000004
value: 2.43E-5
name: kh_2a

735950
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000236
type: Reaction
reversible: false
reactant: 738927
kinetic law: 738990
product: 738940
fast: false
product: 738953
notes: cpxARGi_split
product: 738966
product: 738978
name: H1ARGi_split

738927
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000104

124409
type: LocalParameter
units: metaid_0000004
value: 0.025
name: k5

738940
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000101

738953
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000106

738966
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

738978
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

metaid_0000098
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: A_HT1R_i_deg

metaid_0000095
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.164
initial amount: NaN
in compartment: metaid_0000007
name: PTEN

metaid_0000188
type: Reaction
kinetic law: 736779
product: 736767
reactant: 736755
notes: to regenerate the PIP2, DAG is phosphorylated by DAG kinase (dgk) to produce phosphatidic acid (PA). CDP-DAG synthase (CDS*) adds on CMP to phosphatidic acid.This product DGP-DAG, is the activator donor of the phosphatidyl group to inositol. The PI is phosphorylated by PI kinase and PIP kinase to yield PIP2.
fast: false
reversible: false
name: DAGdeg

124303
type: LocalParameter
units: metaid_0000004
value: 0.15
name: k20_2a

736767
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

736755
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000155
type: Reaction
kinetic law: 735297
product: 735285
product: 735273
reactant: 735261
notes: releaseMEKP_Rafstar
fast: false
reversible: false
name: v45_87

124230
type: LocalParameter
units: metaid_0000004
value: 0.105
name: k48

735285
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

735273
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000036

735261
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

metaid_0000037
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.028395
initial amount: NaN
in compartment: metaid_0000007
name: cpxMEK_Rafstar

metaid_0000207
type: Reaction
kinetic law: 737685
product: 737673
product: 737661
product: 737649
reactant: 737637
fast: false
reversible: false
name: inact_PLCb_Ca_Gq_a_GTP

124349
type: LocalParameter
units: metaid_0000004
value: 0.0133
name: k15_2a

737673
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

737661
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000059

737649
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

737637
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

metaid_0000063
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.5038E-4
initial amount: NaN
in compartment: metaid_0000007
name: PLCb_Ca_Gq_a_GTP

metaid_0000083
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 94.922
initial amount: NaN
in compartment: metaid_0000007
name: PI

metaid_0000225
type: Reaction
kinetic law: 738506
product: 738493
reactant: 738481
fast: false
reversible: false
name: LRinternal_1a

124387
type: LocalParameter
units: metaid_0000004
value: 0.00235
name: ke

738493
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000097

metaid_0000097
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_HT1AR_internal

738481
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000101

metaid_0000167
type: Reaction
kinetic law: 735878
product: 735866
reactant: 735854
reactant: 735842
notes: Abinds_RGi
fast: false
reversible: true
name: TCB_binds2ARGq

124256
type: LocalParameter
units: metaid_0000004
value: 0.007
name: k2r_2a

124255
type: LocalParameter
units: metaid_0000003
value: 1.0
name: k2_2a

735866
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

metaid_0000049
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxA_2AR_Gq

735854
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

735842
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000034
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 4.9691E-4
initial amount: NaN
in compartment: metaid_0000007
name: cpxMEKP_PP2A

metaid_0000137
type: Reaction
kinetic law: 734433
product: 734420
product: 734408
reactant: 734396
fast: false
reversible: false
name: releaseERKPP_MKPPP

124197
type: LocalParameter
units: metaid_0000004
value: 5.0
name: k64

734420
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

734408
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

734396
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

metaid_0000110
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.45
initial amount: NaN
in compartment: metaid_0000007
name: Shc

metaid_0000196
type: Reaction
kinetic law: 737141
modifier: 737129
product: 737117
reactant: 737105
fast: false
reversible: false
name: PKC_AAactRasGEF

124322
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k43_2a

124321
type: LocalParameter
units: metaid_0000005
value: 3.33
name: Km43_2a

737117
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

737105
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000219
type: Reaction
kinetic law: 738240
product: 738228
product: 738216
reactant: 738204
notes: releaseSrcstar_PIP3
fast: false
reversible: false
name: releaseSrcstar

124375
type: LocalParameter
units: metaid_0000004
value: 1.13
name: k27

738228
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000089

738216
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000092

metaid_0000092
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Src_star

738204
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000091

metaid_0000237
type: Reaction
kinetic law: 739038
product: 739026
reactant: 739014
reactant: 739002
notes: Gi_a_GTPbindsRGS
fast: false
reversible: true
name: RGSfor1A_binds_Gia_GTP

124413
type: LocalParameter
units: metaid_0000004
value: 33.32
name: k9r

124410
type: LocalParameter
units: metaid_0000003
value: 20.83
name: k9

739026
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000108

739014
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000109

739002
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000106

metaid_0000079
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.3507E-7
initial amount: NaN
in compartment: metaid_0000007
name: PKC_Ca_DAG

metaid_0000149
type: Reaction
kinetic law: 735007
product: 734995
reactant: 734983
reactant: 734971
fast: false
reversible: true
name: PLA2starbinds_Ca

124221
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k83r

124219
type: LocalParameter
units: metaid_0000003
value: 6.0
name: k83

734995
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000023

734983
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

734971
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

metaid_0000212
type: Reaction
kinetic law: 737904
modifier: 737892
product: 737880
reactant: 737868
fast: false
reversible: false
name: PKC_AAact_Raf

124362
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k31_2a

124359
type: LocalParameter
units: metaid_0000005
value: 66.67
name: Km31_2a

737880
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

737868
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000204
type: Reaction
kinetic law: 737541
product: 737529
reactant: 737517
fast: false
reversible: true
name: releasePKc_Ca_DAGactive

124344
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k24r_2a

124343
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k24_2a

737529
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000080

737517
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

metaid_0000230
type: Reaction
kinetic law: 738675
product: 738663
reactant: 738651
reactant: 738639
notes: Abinds_RGi
fast: false
reversible: true
name: HT_binds1ARGi

124395
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k2r

124394
type: LocalParameter
units: metaid_0000003
value: 100.0
name: k2

738663
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000104

738651
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

metaid_0000103
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxHT1AR_Gitrimer

738639
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000111

metaid_0000111
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: serotonin

metaid_0000164
type: Reaction
kinetic law: 735734
product: 735722
reactant: 735710
reactant: 735698
notes: cpxAR1Abinds_Gi
fast: false
reversible: true
name: HRbindsGqtrimer_GDP

124248
type: LocalParameter
units: metaid_0000004
value: 0.004667
name: k4r_2a

124245
type: LocalParameter
units: metaid_0000003
value: 1.0
name: k4_2a

735722
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

735710
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

735698
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

metaid_0000222
type: Reaction
kinetic law: 738384
product: 738372
reactant: 738360
reactant: 738348
notes: PTENbindsPIP3
fast: false
reversible: true
name: PIP3bindsPTEN

124383
type: LocalParameter
units: metaid_0000004
value: 51.2
name: k28r

124380
type: LocalParameter
units: metaid_0000003
value: 3.2
name: k28

738372
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000096

metaid_0000096
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: cpxPTEN_PIP3

738360
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000089

738348
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

metaid_0000199
type: Reaction
kinetic law: 737286
product: 737274
reactant: 737261
reactant: 737249
fast: false
reversible: true
name: PIP2_binds_PLA2

124330
type: LocalParameter
units: metaid_0000004
value: 0.0012
name: k80r_2a

124329
type: LocalParameter
units: metaid_0000003
value: 0.5
name: k80_2a

737274
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000078

737261
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

737249
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

metaid_0000067
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0026242
initial amount: NaN
in compartment: metaid_0000007
name: PKC_Ca

metaid_0000012
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0021849
initial amount: NaN
in compartment: metaid_0000007
name: Rafstarstar

metaid_0000141
type: Reaction
kinetic law: 734617
product: 734605
reactant: 734593
reactant: 734581
notes: ERKP_bindsMKP_PP
fast: false
reversible: true
name: v58_w4

124207
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k68r

124206
type: LocalParameter
units: metaid_0000003
value: 10.0
name: k68

734605
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000011

734593
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

734581
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

metaid_0000128
type: Reaction
kinetic law: 734010
product: 733998
reactant: 733986
reactant: 733974
notes: Rafstarstar_bindsPP2A
fast: false
reversible: true
name: PP2Abinds_Rafstarstar

124182
type: LocalParameter
units: metaid_0000004
value: 24.0
name: k53r

124180
type: LocalParameter
units: metaid_0000003
value: 1.9161
name: k53

733998
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000014

733986
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

733974
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

metaid_0000146
type: Reaction
kinetic law: 734860
product: 734847
product: 734835
reactant: 734823
notes: releaseMEKPP_ERKPP
fast: false
reversible: false
name: v55_u4

124214
type: LocalParameter
units: metaid_0000004
value: 15.0
name: k62

734847
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

734835
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

734823
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

metaid_0000018
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 6.2945E-5
initial amount: NaN
in compartment: metaid_0000007
name: cpxERKP_MEKPP

747729
type: Reaction
kinetic law: 739966
product: 739954
product: 739942
reactant: 739930
fast: false
reversible: false
name: Ketanserin2ARGq_split

124450
type: LocalParameter
units: metaid_0000004
value: 1.0E-4
name: k_ant_split

739954
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000123

metaid_0000123
type: Species
constant: false
boundary condition: false
has only substance units: false
initial concentration: NaN
initial amount: 0.0
in compartment: metaid_0000007
name: productX

739942
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

739930
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

metaid_0000138
type: Reaction
kinetic law: 734481
product: 734469
reactant: 734457
reactant: 734445
notes: MKPbinds_ERKPP
fast: false
reversible: true
name: ERK_PPbinds_MKP

124202
type: LocalParameter
units: metaid_0000004
value: 20.2
name: k63r

124199
type: LocalParameter
units: metaid_0000003
value: 31.5625
name: k63

734469
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000025

734457
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

734445
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

metaid_0000201
type: Reaction
kinetic law: 737395
modifier: 737382
product: 737370
product: 737358
reactant: 737346
fast: false
reversible: false
name: IP3DAG_byPIP2_PLCCa

124336
type: LocalParameter
units: metaid_0000004
value: 10.0
name: k16_2a

124335
type: LocalParameter
units: metaid_0000005
value: 40.13
name: Km16_2a

737370
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

737358
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

737346
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000006
type: SBMLUnitsDef
unit: 733780
unit: 733768
unit: 733756
name: Mps

733780
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 1.0
kind: MOLE

733768
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

733756
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: LITRE

metaid_0000179
type: Reaction
kinetic law: 736380
product: 736368
reactant: 736356
reactant: 736344
fast: false
reversible: true
name: PKC_binds_Ca

124280
type: LocalParameter
units: metaid_0000004
value: 0.5
name: k21r_2a

124279
type: LocalParameter
units: metaid_0000003
value: 0.6
name: k21_2a

736368
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

736356
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

736344
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000066

metaid_0000009
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.010263
initial amount: NaN
in compartment: metaid_0000007
name: cpxERK_PP_MKP_PP

metaid_0000213
type: Reaction
kinetic law: 737952
modifier: 737940
product: 737928
reactant: 737916
fast: false
reversible: false
name: RafactbyPKC_DAG_AAactive

124364
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k25_2a

124363
type: LocalParameter
units: metaid_0000005
value: 66.67
name: Km25_2a

737928
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

737916
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000190
type: Reaction
kinetic law: 736863
modifier: 736851
product: 736839
reactant: 736827
fast: false
reversible: false
name: PKC_Ca_DAGactive_actRasGAP

124306
type: LocalParameter
units: metaid_0000005
value: 3.33
name: Km38_2a

124305
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k38_2a

736839
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

736827
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000173
type: Reaction
kinetic law: 736072
product: 736059
reactant: 736047
fast: false
reversible: false
name: L2aRinternal

124264
type: LocalParameter
units: metaid_0000004
value: 0.00235
name: ke_2a

736059
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000054

736047
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

metaid_0000130
type: Reaction
kinetic law: 734106
product: 734094
reactant: 734082
reactant: 734070
notes: PLA2binds_ERKPP
fast: false
reversible: true
name: ERKPPbinds_PLA2

124185
type: LocalParameter
units: metaid_0000004
value: 40.0
name: k71r

124184
type: LocalParameter
units: metaid_0000003
value: 3.9
name: k71

734094
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

734082
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

734070
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000029

metaid_0000248
type: Reaction
kinetic law: 739580
modifier: 739568
product: 739556
reactant: 739544
fast: false
reversible: false
name: ShcactbySrcstar

124432
type: LocalParameter
units: metaid_0000005
value: 8.0
name: km_bysrc

124431
type: LocalParameter
units: metaid_0000004
value: 1.6
name: kcat_bysrc

739556
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

739544
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000110

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

metaid_0000125
type: Reaction
kinetic law: 733878
product: 733865
reactant: 733853
reactant: 733841
notes: v56_w1, h1, ERKPP_bindsMKPPP
fast: false
reversible: true
name: v56_w1

124176
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k65r

124175
type: LocalParameter
units: metaid_0000003
value: 45.0
name: k65

733865
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

733853
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

733841
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

W3 CDTF: Fri Nov 28 11:16:16 GMT 2008

metaid_0000231
type: Reaction
kinetic law: 738723
product: 738711
reactant: 738699
reactant: 738687
notes: HTbinds_HT1AR
fast: false
reversible: true
name: HTbinds_1AR

124397
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k1r

124396
type: LocalParameter
units: metaid_0000003
value: 0.45
name: k1

738711
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000101

738699
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000111

738687
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000100

metaid_0000038
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.078866
initial amount: NaN
in compartment: metaid_0000007
name: MEK

metaid_0000185
type: Reaction
kinetic law: 736669
modifier: 736657
product: 736645
reactant: 736633
fast: false
reversible: false
name: AAfrom_PIP2_PLA2_Ca

124296
type: LocalParameter
units: metaid_0000004
value: 36.0
name: k83_2a

124295
type: LocalParameter
units: metaid_0000005
value: 20.0
name: Km83_2a

736645
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

736633
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000240
type: Reaction
kinetic law: 739194
product: 739182
reactant: 739170
reactant: 739158
notes: Shcstarbinds_Grb2
fast: false
reversible: true
name: v38_Grb2_binds_Shcstar

124417
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k36r

124416
type: LocalParameter
units: metaid_0000003
value: 3.0
name: k36

739182
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

metaid_0000115
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: Shcstar_Grb2

739170
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000112

739158
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

metaid_0000245
type: Reaction
kinetic law: 739424
product: 739412
reactant: 739400
notes: dep_Grb2SosP
fast: false
reversible: false
name: dep_Sos_P

124426
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k78

739412
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

739400
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000119

metaid_0000084
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 1.8983
initial amount: NaN
in compartment: metaid_0000007
name: PIP

metaid_0000228
type: Reaction
kinetic law: 738603
reactant: 738591
fast: false
reversible: false
name: ligand1a_deg

124391
type: LocalParameter
units: metaid_0000004
value: 2.43E-5
name: kh

738591
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000111

metaid_0000210
type: Reaction
kinetic law: 737807
modifier: 737794
product: 737781
reactant: 737769
fast: false
reversible: false
name: PKC_Ca_DAGactive_actRaf

124356
type: LocalParameter
units: metaid_0000005
value: 66.67
name: Km29_2a

124353
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k29_2a

737781
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

737769
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000157
type: Reaction
kinetic law: 735394
modifier: 735382
product: 735370
reactant: 735358
notes: releaseRasGDPRasGAP
fast: false
reversible: false
name: RasGTPactbyGAP

124234
type: LocalParameter
units: metaid_0000005
value: 1.01
name: Km41

124233
type: LocalParameter
units: metaid_0000004
value: 10.0
name: k41

735370
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

735358
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

metaid_0000209
type: Reaction
kinetic law: 737757
product: 737745
reactant: 737733
fast: false
reversible: false
name: PIgene

124351
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k_PA

737745
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000083

737733
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000082

metaid_0000132
type: Reaction
kinetic law: 734203
product: 734191
product: 734178
reactant: 734166
notes: releaseRafstar_MEKPP
fast: false
reversible: false
name: v47_89

124187
type: LocalParameter
units: metaid_0000004
value: 0.105
name: k50

734191
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

734178
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

734166
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000033

metaid_0000182
type: Reaction
kinetic law: 736525
product: 736513
reactant: 736501
reactant: 736489
fast: false
reversible: true
name: AA_binds_PKC_Ca

124288
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k58r_2a

124287
type: LocalParameter
units: metaid_0000003
value: 0.0012
name: k58_2a

736513
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000072

736501
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

736489
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

metaid_0000174
type: Reaction
kinetic law: 736133
product: 736120
product: 736108
product: 736096
reactant: 736084
fast: false
reversible: false
name: cpxARGq_split

124266
type: LocalParameter
units: metaid_0000004
value: 0.04
name: k5_2a

736120
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

736108
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

736096
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

736084
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000049

metaid_0000169
type: Reaction
kinetic law: 735938
product: 735926
fast: false
reversible: true
name: insertion

124259
type: LocalParameter
units: metaid_0000006
value: 0.0
name: Vr_2a

124258
type: LocalParameter
units: metaid_0000004
value: 0.0
name: kt_2a

735926
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

metaid_0000126
type: Reaction
kinetic law: 733914
product: 733902
reactant: 733890
notes: releaseERKP_MKP_PP
fast: false
reversible: false
name: w2

124177
type: LocalParameter
units: metaid_0000004
value: 0.092
name: k66

733902
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000010

733890
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000009

metaid_0000144
type: Reaction
kinetic law: 734762
product: 734750
reactant: 734738
reactant: 734726
notes: PP2Abinds_Rafstar
fast: false
reversible: true
name: Rafstarbinds_PP2A

124211
type: LocalParameter
units: metaid_0000004
value: 24.0
name: k51r

124210
type: LocalParameter
units: metaid_0000003
value: 1.9161
name: k51

734750
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000016

734738
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

734726
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

747725
type: Reaction
kinetic law: 739870
product: 739858
reactant: 739845
reactant: 739833
fast: false
reversible: true
name: Ket_2ARGq_split

124445
type: LocalParameter
units: metaid_0000004
value: 2.5
name: k2r_ant

124444
type: LocalParameter
units: metaid_0000003
value: 1.0
name: k2_ant

739858
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000122

739845
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

739833
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

metaid_0000242
type: Reaction
kinetic law: 739290
product: 739278
reactant: 739266
reactant: 739254
notes: Shcstarbinds_Grb2sos
fast: false
reversible: true
name: v41_83_Grb2_Sosbinds_Shc

124421
type: LocalParameter
units: metaid_0000004
value: 0.0429
name: k34r

124420
type: LocalParameter
units: metaid_0000003
value: 9.0
name: k34

739278
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

739266
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000116

739254
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

metaid_0000161
type: Reaction
kinetic law: 735590
product: 735578
reactant: 735565
reactant: 735553
notes: Gi_a_GTPbindsRGS
fast: false
reversible: true
name: RGSfor2A_binds_Gqa_GTP

124241
type: LocalParameter
units: metaid_0000004
value: 33.32
name: k9r_2a

124240
type: LocalParameter
units: metaid_0000003
value: 20.83
name: k9_2a

735578
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000048

735565
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

735553
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000047

metaid_0000142
type: Reaction
kinetic law: 734665
product: 734653
product: 734641
reactant: 734629
notes: releaseERKPP_Rafstar
fast: false
reversible: false
name: releaseRafstarPP2A

124208
type: LocalParameter
units: metaid_0000004
value: 6.0
name: k76

734653
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000012

734641
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

734629
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000015

metaid_0000177
type: Reaction
kinetic law: 736283
product: 736271
reactant: 736259
reactant: 736247
fast: false
reversible: true
name: PLCb_Gq_a_GTPbinds_Ca

124274
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k14r_2a

124273
type: LocalParameter
units: metaid_0000003
value: 30.0
name: k14_2a

736271
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

736259
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000028

736247
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000061

W3 CDTF: Wed Oct 07 15:45:53 BST 2009

metaid_0000229
type: Reaction
kinetic law: 738627
product: 738615
fast: false
reversible: true
name: insertion_1a

124393
type: LocalParameter
units: metaid_0000004
value: 0.0
name: kt

124392
type: LocalParameter
units: metaid_0000006
value: 0.0
name: Vr

738615
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000100

metaid_0000211
type: Reaction
kinetic law: 737856
modifier: 737843
product: 737831
reactant: 737819
fast: false
reversible: false
name: PKC_Ca_AAactRaf

124358
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k30_2a

124357
type: LocalParameter
units: metaid_0000005
value: 66.67
name: Km30_2a

737831
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

737819
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000158
type: Reaction
kinetic law: 735442
product: 735430
reactant: 735418
reactant: 735406
notes: Rafbinds_RasGTP
fast: false
reversible: true
name: RasGTPbinds_Raf

124236
type: LocalParameter
units: metaid_0000004
value: 0.5
name: k45r

124235
type: LocalParameter
units: metaid_0000003
value: 24.0
name: k45

735430
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000040

735418
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

735406
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000041

metaid_0000189
type: Reaction
kinetic law: 736815
product: 736803
reactant: 736791
fast: false
reversible: false
name: degRasGAPstar

124304
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k33_2a

736803
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

736791
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

metaid_0000252
type: Reaction
kinetic law: 739773
modifier: 739761
product: 739749
reactant: 739737
fast: false
reversible: false
name: RasGDPbyRasGEFstar

124441
type: LocalParameter
units: metaid_0000005
value: 0.50505
name: km37_2a

124440
type: LocalParameter
units: metaid_0000004
value: 0.02
name: k37_2a

739749
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000042

739737
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000044

metaid_0000193
type: Reaction
kinetic law: 736997
modifier: 736985
product: 736973
reactant: 736960
fast: false
reversible: false
name: PKC_Ca_AAactRasGAP

124314
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k39_2a

124313
type: LocalParameter
units: metaid_0000005
value: 3.33
name: Km39_2a

736973
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

736960
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000150
type: Reaction
kinetic law: 735056
product: 735043
reactant: 735031
reactant: 735019
notes: ERKPbinds_MEKPP
fast: false
reversible: true
name: v54_u3

124223
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k61r

124222
type: LocalParameter
units: metaid_0000003
value: 3.2
name: k61

735043
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000018

735031
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

735019
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000031

metaid_0000216
type: Reaction
kinetic law: 738096
product: 738084
reactant: 738072
reactant: 738060
notes: PIP2binds_PI3Kstar
fast: false
reversible: true
name: PIP2bindfsPI3Kstar

124371
type: LocalParameter
units: metaid_0000004
value: 2.5
name: k24r

124370
type: LocalParameter
units: metaid_0000003
value: 0.7813
name: k24

738084
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000088

metaid_0000088
type: Species
constant: false
boundary condition: false
has only substance units: false
substance units: mole
initial concentration: 0.0
initial amount: NaN
in compartment: metaid_0000007
name: PIP2_PI3Kstar

738072
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

738060
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

metaid_0000208
type: Reaction
kinetic law: 737721
product: 737709
reactant: 737697
fast: false
reversible: false
name: degradeAA

124350
type: LocalParameter
units: metaid_0000004
value: 0.4
name: k79_2a

737709
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

737697
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

metaid_0000234
type: Reaction
kinetic law: 738867
product: 738855
reactant: 738843
reactant: 738831
fast: false
reversible: false
name: Gitrimerization

124406
type: LocalParameter
units: metaid_0000003
value: 6.0
name: k6

738855
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000102

738843
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000107

738831
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

metaid_0000243
type: Reaction
kinetic law: 739338
product: 739326
reactant: 739314
reactant: 739302
notes: ShcstarGrb2_binds_Sos
fast: false
reversible: true
name: v40_Sosbinds_ShcstarGrb2

124423
type: LocalParameter
units: metaid_0000004
value: 0.064
name: k37r

124422
type: LocalParameter
units: metaid_0000003
value: 30.0
name: k37

739326
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000117

739314
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000113

739302
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000115

metaid_0000226
type: Reaction
kinetic law: 738542
product: 738530
reactant: 738518
fast: false
reversible: false
name: LR_internal_deg

124388
type: LocalParameter
units: metaid_0000004
value: 6.67E-4
name: v62

738530
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000098

738518
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000097

metaid_0000186
type: Reaction
kinetic law: 736718
modifier: 736706
product: 736694
reactant: 736682
fast: false
reversible: false
name: AAfrom_PLA2_Ca

124298
type: LocalParameter
units: metaid_0000005
value: 20.0
name: Km64_2a

124297
type: LocalParameter
units: metaid_0000004
value: 5.4
name: k64_2a

736694
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

736682
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000070

metaid_0000162
type: Reaction
kinetic law: 735638
product: 735626
product: 735614
reactant: 735602
fast: false
reversible: false
name: Gqitrimer_GDP_to_Gbr_Gq_a_GTP

124242
type: LocalParameter
units: metaid_0000004
value: 1.0E-4
name: k7_2a

735626
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000058

735614
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

735602
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

metaid_0000178
type: Reaction
kinetic law: 736331
product: 736319
reactant: 736307
reactant: 736295
fast: false
reversible: true
name: PLCb_Ca_binds_Gq_a_GTP

124278
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k13r_2a

124275
type: LocalParameter
units: metaid_0000003
value: 25.2
name: k13_2a

736319
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000063

736307
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000057

736295
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000062

metaid_0000180
type: Reaction
kinetic law: 736429
product: 736416
reactant: 736404
reactant: 736392
fast: false
reversible: true
name: DAGbindsPKC_Ca

124282
type: LocalParameter
units: metaid_0000004
value: 8.6348
name: k23r_2a

124281
type: LocalParameter
units: metaid_0000003
value: 0.008
name: k23_2a

736416
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000079

736404
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000067

736392
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

metaid_0000153
type: Reaction
kinetic law: 735200
product: 735188
product: 735176
reactant: 735164
notes: releaseMEK_PP2A
fast: false
reversible: false
name: v51_93

124227
type: LocalParameter
units: metaid_0000004
value: 6.0
name: k56

735188
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

735176
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

735164
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

metaid_0000205
type: Reaction
kinetic law: 737589
product: 737577
reactant: 737565
reactant: 737553
fast: false
reversible: true
name: AAbinds_PKC_DAG

124346
type: LocalParameter
units: metaid_0000004
value: 2.0
name: k59r_2a

124345
type: LocalParameter
units: metaid_0000003
value: 0.018
name: k59_2a

737577
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000069

737565
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000068

737553
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000071

metaid_0000223
type: Reaction
kinetic law: 738433
product: 738420
product: 738408
reactant: 738396
notes: releasePIP2PTEN
fast: false
reversible: false
name: releasePTEN

124384
type: LocalParameter
units: metaid_0000004
value: 12.8
name: k29

738420
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

738408
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000095

738396
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000096

747723
type: Reaction
kinetic law: 739821
product: 739809
reactant: 739797
reactant: 739785
fast: false
reversible: true
name: Ketanserinbinds_2AR

124443
type: LocalParameter
units: metaid_0000004
value: 2.5
name: k1r_ant

124442
type: LocalParameter
units: metaid_0000003
value: 1.0
name: k1_ant

739809
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000121

739797
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

739785
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000120

metaid_0000165
type: Reaction
kinetic law: 735782
product: 735770
reactant: 735758
reactant: 735746
notes: HT1ARbinds_Gitrimer
fast: false
reversible: true
name: Gqtrimer_GDP_with_5HT2AR

124250
type: LocalParameter
units: metaid_0000004
value: 1.67
name: k3r_2a

124249
type: LocalParameter
units: metaid_0000003
value: 1.0
name: k3_2a

735770
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000050

735758
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000056

735746
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

metaid_0000135
type: Reaction
kinetic law: 734347
product: 734335
reactant: 734323
reactant: 734311
notes: MEKPPbinds_PP2A
fast: false
reversible: true
name: v48_90

124195
type: LocalParameter
units: metaid_0000004
value: 24.0
name: k57r

124194
type: LocalParameter
units: metaid_0000003
value: 1.92
name: k57

734335
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000013

734323
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

734311
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

metaid_0000194
type: Reaction
kinetic law: 737045
modifier: 737033
product: 737021
reactant: 737009
fast: false
reversible: false
name: PKC_DAG_AAactive_actRasGAP

124316
type: LocalParameter
units: metaid_0000005
value: 3.33
name: Km32_2a

124315
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k32_2a

737021
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000077

737009
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000043

metaid_0000217
type: Reaction
kinetic law: 738144
product: 738132
product: 738120
reactant: 738108
notes: releasePIP3
fast: false
reversible: false
name: releasePI3Kstar

124372
type: LocalParameter
units: metaid_0000004
value: 0.625
name: k25

738132
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000087

738120
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000089

738108
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000088

metaid_0000129
type: Reaction
kinetic law: 734058
product: 734046
product: 734034
reactant: 734022
notes: releasePLA2star_ERKPP
fast: false
reversible: false
name: releasePLA2star

124183
type: LocalParameter
units: metaid_0000004
value: 10.0
name: k72

734046
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000017

734034
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000026

734022
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000027

metaid_0000235
type: Reaction
kinetic law: 738915
product: 738903
product: 738891
reactant: 738879
fast: false
reversible: false
name: Gitrimer_GDP_to_Gbr,Gi_a_GTP

124407
type: LocalParameter
units: metaid_0000004
value: 1.0E-4
name: k7

738903
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

738891
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000106

738879
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000102

metaid_0000147
type: Reaction
kinetic law: 734910
product: 734897
reactant: 734884
reactant: 734872
notes: u1
fast: false
reversible: true
name: u1

124216
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k59r

124215
type: LocalParameter
units: metaid_0000003
value: 20.0
name: k59

734897
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000019

734884
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000020

734872
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000032

metaid_0000156
type: Reaction
kinetic law: 735346
product: 735334
reactant: 735321
reactant: 735309
notes: MEKbinds_Rafstar
fast: false
reversible: true
name: v44_86

124232
type: LocalParameter
units: metaid_0000004
value: 0.42
name: k47r

124231
type: LocalParameter
units: metaid_0000003
value: 3.28
name: k47

735334
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000037

735321
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000039

735309
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000038

metaid_0000202
type: Reaction
kinetic law: 737455
modifier: 737443
product: 737431
product: 737419
reactant: 737407
fast: false
reversible: false
name: IP3DAG_byPIP2_PLCCaGq

124338
type: LocalParameter
units: metaid_0000004
value: 48.0
name: k17_2a

124337
type: LocalParameter
units: metaid_0000005
value: 5.0
name: Km17_2a

737431
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000065

737419
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000064

737407
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000045

metaid_0000220
type: Reaction
kinetic law: 738288
product: 738276
reactant: 738264
reactant: 738252
fast: false
reversible: true
name: Srcstar_bindsCsk

124377
type: LocalParameter
units: metaid_0000004
value: 56.0
name: k30r

124376
type: LocalParameter
units: metaid_0000003
value: 2.33
name: k30

738276
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000094

738264
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000093

738252
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000092

metaid_0000197
type: Reaction
kinetic law: 737189
modifier: 737177
product: 737165
reactant: 737153
fast: false
reversible: false
name: PKC_Ca_AAactRasGEF

124324
type: LocalParameter
units: metaid_0000004
value: 4.0
name: k42_2a

124323
type: LocalParameter
units: metaid_0000005
value: 3.33
name: Km42_2a

737165
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

737153
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

metaid_0000154
type: Reaction
kinetic law: 735249
product: 735236
reactant: 735224
reactant: 735212
notes: PP2Abinds_MEKP
fast: false
reversible: true
name: v50_92

124229
type: LocalParameter
units: metaid_0000004
value: 24.0
name: k55r

124228
type: LocalParameter
units: metaid_0000003
value: 1.92
name: k55

735236
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000034

735224
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000036

735212
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000035

ORG:
  orgname: Weill Medical College of Cornell University
n:
  given: Chiung-wen Violet
  family: Chang

metaid_0000249
type: Reaction
kinetic law: 739628
product: 739616
product: 739604
reactant: 739592
notes: degShcstar
fast: false
reversible: false
name: v36_depShc_star

124436
type: LocalParameter
units: metaid_0000006
value: 0.17
name: Vm_33

124433
type: LocalParameter
units: metaid_0000005
value: 0.34
name: Km_33

739616
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000046

739604
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000110

739592
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000114

metaid_0000191
type: Reaction
kinetic law: 736900
product: 736888
reactant: 736876
fast: false
reversible: false
name: GEF_deact

124307
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k36_2a

736888
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000075

736876
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000076

metaid_0000214
type: Reaction
kinetic law: 738000
product: 737988
reactant: 737976
reactant: 737964
notes: Gi_brbinds_PI3K
fast: false
reversible: true
name: bindingofPI3K_Gibr

124368
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k22r

124365
type: LocalParameter
units: metaid_0000003
value: 35.0
name: k22

737988
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000086

737976
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000105

737964
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000085

metaid_0000232
type: Reaction
kinetic law: 738771
product: 738759
reactant: 738747
reactant: 738735
notes: HT1ARbinds_Gitrimer
fast: false
reversible: true
name: Gitrimer_GDP_with_5HT1AR

124403
type: LocalParameter
units: metaid_0000004
value: 0.1
name: k3r

124398
type: LocalParameter
units: metaid_0000003
value: 0.0599
name: k3

738759
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000103

738747
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000102

738735
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000100

metaid_0000166
type: Reaction
kinetic law: 735830
product: 735818
reactant: 735806
reactant: 735794
notes: HTbinds_HT1AR
fast: false
reversible: true
name: TCBbinds_2AR

124254
type: LocalParameter
units: metaid_0000004
value: 2.5
name: k1r_2a

124251
type: LocalParameter
units: metaid_0000003
value: 1.0
name: k1_2a

735818
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000055

735806
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000051

735794
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000008

metaid_0000136
type: Reaction
kinetic law: 734383
product: 734371
reactant: 734359
notes: degMKP_PP
fast: false
reversible: false
name: MKP_PPdegrade

124196
type: LocalParameter
units: metaid_0000004
value: 1.0
name: k82

734371
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000022

734359
type: SpeciesReference
stoichiometry: 1.0
species: metaid_0000030

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

ORG:
  orgname: EMBL-EBI
n:
  given: Lukas
  family: Endler

ORG:
  orgname: Weill Medical College of Cornell University
n:
  given: Chiung-wen Violet
  family: Chang

W3 CDTF: Wed Oct 07 15:45:53 BST 2009

W3 CDTF: Wed Oct 07 15:45:53 BST 2009

ORG:
  orgname: Weill Medical College of Cornell University
n:
  given: Chiung-wen Violet
  family: Chang