Weill Medical College of Cornell University
to regenerate the PIP2, DAG is phosphorylated by DAG kinase (dgk) to produce phosphatidic acid (PA). CDP-DAG synthase (CDS*) adds on CMP to phosphatidic acid.This product DGP-DAG, is the activator donor of the phosphatidyl group to inositol. The PI is phosphorylated by PI kinase and PIP kinase to yield PIP2.
This is the model of Erk1/2 activation by serotonin 5-HT1A and 5-HT2A receptor subtypes as described in: Towards a quantitative representation of the cell signaling mechanisms of hallucinogens: Measurement and mathematical modeling of 5-HT1A and 5-HT2A receptor-mediated ERK1/2 activation byChiung-wen Chang, Ethan Poteet, John A. Schetz, Zeynep H. Gümüş and Harel Weinstein ,Neuropharmacology 2008, pumedID:18762202 This model originates from BioModels Database: A Database of Annotated Published Models. It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer toCC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.. To cite BioModels Database, please use:Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.