MODEL0913242281
type: SBMLModel
parameter: 214983
rule: 214932
parameter: 214981
parameter: 214943
rule: 214923
parameter: 214941
parameter: 214975
parameter: 214973
parameter: 214971
parameter: 214972
rule: 214925
units def: 725154
rule: 214918
parameter: 214960
time units: 725154
parameter: 214939
rule: 214928
parameter: 214959
parameter: 214955
parameter: 214978
parameter: 214938
parameter: 214958
rule: 214921
notes: This a model from the article: A kinetic model of the cyclin E/Cdk2 developmental timer in Xenopus laevis embryos. Ciliberto A, Petrus MJ, Tyson JJ, Sible JC. Biophys Chem 2003 Jul 1;104(3):573-89 12914904 , Abstract: Early cell cycles of Xenopus laevis embryos are characterized by rapid oscillations in the activity of two cyclin-dependent kinases. Cdk1 activity peaks at mitosis, driven by periodic degradation of cyclins A and B. In contrast, Cdk2 activity oscillates twice per cell cycle, despite a constant level of its partner, cyclin E. Cyclin E degrades at a fixed time after fertilization, normally corresponding to the midblastula transition. Based on published data and new experiments, we constructed a mathematical model in which: (1) oscillations in Cdk2 activity depend upon changes in phosphorylation, (2) Cdk2 participates in a negative feedback loop with the inhibitory kinase Wee1; (3) cyclin E is cooperatively removed from the oscillatory system; and (4) removed cyclin E is degraded by a pathway activated by cyclin E/Cdk2 itself. The model's predictions about embryos injected with Xic1, a stoichiometric inhibitor of cyclin E/Cdk2, were experimentally validated. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Ciliberto A, Petrus MJ, Tyson JJ, Sible JC. (2003) - version03 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable…
area units: area
parameter: 214956
parameter: 214954
parameter: 214966
rule: 214933
parameter: 214984
parameter: 214982
parameter: 214969
volume units: 970346
parameter: 214980
parameter: 214942
parameter: 214965
parameter: 214940
parameter: 214963
compartment: 214915
rule: 214935
rule: 214926
units def: 725130
rule: 214919
substance units: 608838
length unit: 335510
parameter: 214979
parameter: 214977
parameter: 214937
parameter: 214957
rule: 214931
rule: 214922
parameter: 214953
parameter: 214976
rule: 214930
parameter: 214951
parameter: 214936
parameter: 214974
parameter: 214968
parameter: 214970
rule: 214934
is described by: http://identifiers.org/pubmed/12914904
parameter: 214964
parameter: 214950
parameter: 214962
rule: 214924
rule: 214917
parameter: 214961
rule: 214927
name: Ciliberto2003_CyclinECdk2Timer
rule: 214929
curated: false
units def: 725106
rule: 214920
parameter: 214967

214983
type: Parameter
constant: true
units: dimensionless
value: 4.0
name: n

214981
type: Parameter
constant: true
value: 0.001
name: epsilon

214943
type: Parameter
constant: true
units: 725130
value: 1.5
name: kwinact

725130
type: SBMLUnitsDef
unit: 725142
name: first_order_rate_constant

725142
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 60.0
kind: SECOND

214941
type: Parameter
constant: true
units: dimensionless
value: 8.0
name: Wee1_total

214975
type: Parameter
constant: true
units: 725130
value: 0.1
name: kassoc

214973
type: Parameter
constant: true
units: 725130
value: 0.02
name: kon

214971
type: Parameter
constant: true
units: 725130
value: 1.5
name: kwee

214972
type: Parameter
constant: true
units: 725130
value: 0.1
name: k25A

725154
type: SBMLUnitsDef
unit: 725166
name: time

725166
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

214960
type: Parameter
constant: true
units: 725130
value: 0.023
name: kdact

214939
type: Parameter
constant: true
units: dimensionless
value: 0.01
name: Jwact

214959
type: Parameter
constant: false
units: dimensionless
value: NaN
name: Heav

214955
type: Parameter
constant: true
units: 725130
value: 0.6
name: kiinact

214978
type: Parameter
constant: true
units: 725130
value: 0.01
name: kxdeg

214938
type: Parameter
constant: false
units: dimensionless
value: 1.02
name: Wee1_a

214958
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: Deg_a

214956
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: Cdk2_CycErem

214954
type: Parameter
constant: true
units: 725130
value: 0.15
name: kiact

214966
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: Xic_Cdk2_CycErem

214984
type: Parameter
constant: true
units: dimensionless
value: 0.4
name: L

214982
type: Parameter
constant: false
units: dimensionless
value: NaN
name: pool

214969
type: Parameter
constant: false
units: dimensionless
value: NaN
name: Cyc_total

214980
type: Parameter
constant: true
units: dimensionless
value: 0.0
name: Deg

214942
type: Parameter
constant: true
units: 725130
value: 0.75
name: kwact

214965
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: Xic_PCdk2_CycE

214940
type: Parameter
constant: true
units: dimensionless
value: 0.01
name: Jwinact

214963
type: Parameter
constant: false
units: dimensionless
value: 3.0
name: Xic

214915
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

214979
type: Parameter
constant: false
units: dimensionless
value: NaN
name: phi

214977
type: Parameter
constant: true
units: 725130
value: 0.017
name: kedeg

214937
type: Parameter
constant: false
units: dimensionless
value: 0.94
name: PCdk2_CycE

214957
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: PCdk2_CycErem

214953
type: Parameter
constant: true
units: dimensionless
value: 0.01
name: Jiinact

214976
type: Parameter
constant: true
units: 725130
value: 0.001
name: kdissoc

214951
type: Parameter
constant: true
units: dimensionless
value: 0.01
name: Jiact

214936
type: Parameter
constant: false
units: dimensionless
value: 0.06
name: Cdk2_CycE

214974
type: Parameter
constant: true
units: 725130
value: 1.0E-4
name: koff

214968
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: Xicrem

214970
type: Parameter
constant: false
units: dimensionless
value: NaN
name: Xic_total

214964
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: Xic_Cdk2_CycE

214950
type: Parameter
constant: false
units: dimensionless
value: 0.6
name: Kin_a

214962
type: Parameter
constant: false
units: dimensionless
value: NaN
name: x

214961
type: Parameter
constant: true
units: dimensionless
value: 0.3
name: theta

725106
type: SBMLUnitsDef
unit: 725118
name: minute

725118
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 60.0
kind: SECOND

214967
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: Xic_PCdk2_CycErem