MODEL0912835813
type: SBMLModel
units def: 690018
parameter: 982303
parameter: 982295
rule: 982241
parameter: 982311
parameter: 982254
rule: 982250
parameter: 982252
parameter: 982262
parameter: 982272
rule: 982240
rule: 982233
parameter: 982260
parameter: 982270
rule: 982234
length unit: 335510
units def: 690151
rule: 982236
parameter: 982268
parameter: 982278
parameter: 982288
parameter: 982298
parameter: 982286
parameter: 982296
parameter: 982280
parameter: 982290
parameter: 982306
units def: 690261
volume units: 970346
units def: 690212
parameter: 982304
units def: 690127
rule: 982242
parameter: 982312
parameter: 982255
rule: 982246
parameter: 982263
curated: false
parameter: 982283
rule: 982232
parameter: 982271
rule: 982249
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units def: 690309
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units def: 690175
parameter: 982279
parameter: 982299
parameter: 982258
rule: 982245
parameter: 982291
parameter: 982256
parameter: 982266
parameter: 982276
compartment: 982228
parameter: 982307
parameter: 982264
parameter: 982274
parameter: 982284
parameter: 982294
parameter: 982282
rule: 982244
units def: 690285
rule: 982231
units def: 689994
parameter: 982302
substance units: 608838
parameter: 982300
time units: 690407
is described by: http://identifiers.org/pubmed/6326602
units def: 690054
rule: 982237
parameter: 982292
parameter: 982308
area units: area
notes: This a model from the article: A mechanistic model of ACTH-stimulated cortisol secretion. Dempsher DP, Gann DS, Phair RD. Am J Physiol 1984 Apr;246(4 Pt 2):R587-96 6326602 , Abstract: Adrenal secretory rates of cortisol and arterial concentrations of adrenocorticotropin (ACTH) were measured in conscious trained dogs subjected to intravenous infusion of ACTH. To investigate the causal relation of ACTH to the secretion of cortisol, a mechanistic mathematical model based on current hypotheses of adrenocortical function was constructed and tested. It is widely believed that ACTH stimulates cortisol secretion through adenosine 3',5'-cyclic monophosphate (cAMP), which provides substrate cholesterol by activating cholesterol ester hydrolase and facilitating transport of cholesterol to the side-chain cleavage enzyme. In addition, cholesterol modulates its own synthesis by inhibiting beta-hydroxy-beta-methylglutaryl (HMG)-CoA reductase in the adrenocortical cell. These and other steps in the biosynthetic reaction sequence were described using differential equations subject to the additional constraints imposed by available measurements of intracellular quantities. The resulting model is consistent with many of the known characteristics of the canine adrenal response to ACTH. In this model, steady-state nonlinearities arise from cooperative binding of cAMP to its receptor protein and saturation of mitochondrial pregnenolone transport. The transient response is dominated by a depletable pool of intracellular free cholesterol. Other inferences based on the model are presented, and a quantifiable cellular basis for increased adrenal sensitivity to ACTH is proposed. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Dempsher DP, Gann DS, Phair RD. (1984) - version03 The original CellML model was created by: Lloyd, Catherine, May c.lloyd@aukland.ac.nz The University of Auckland The Bioengineering Institute This model origin…
name: Dempsher1984_ACTH_CortisolSecretion
parameter: 982259

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982303
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value: 0.01
name: Kcb

690261
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690273
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982295
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value: 0.64
name: HYPR

690175
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name: nmol_g

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982311
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name: AH

982254
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units: dimensionless
value: 0.013
name: Ko

982252
type: Parameter
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units: 690175
value: 0.95
name: cAMP

982262
type: Parameter
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units: 690091
value: NaN
name: ACTH

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982272
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982260
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982278
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name: CHOC

982288
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name: S

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units: 690175
value: 3000.0
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value: 3.03
name: CHON

982306
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value: 1890.0
name: Vm

982304
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units: 690261
value: 3.3E-4
name: Kcf

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982312
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982255
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982263
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name: IS

982283
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982271
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name: LH_CORT

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982228
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spatial dimensions: 3.0

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982284
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982294
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982282
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units: 690261
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982302
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name: Lmtr

982292
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name: PRO

982308
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982259
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value: 6.0
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982310
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982267
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name: Kd

982287
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982275
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