MODEL0912452142
type: SBMLModel
rule: 756093
parameter: 756137
parameter: 756122
units def: 676097
units def: 676241
curated: false
notes: This a model from the article: Rhythmic secretion of prolactin in rats: action of oxytocin coordinated by vasoactive intestinal polypeptide of suprachiasmatic nucleus origin. Egli M, Bertram R, Sellix MT, Freeman ME. Endocrinology 2004 Jul;145(7):3386-94 15033917 , Abstract: Prolactin (PRL) is secreted from lactotrophs of the anterior pituitary gland of rats in a unique pattern in response to uterine cervical stimulation (CS) during mating. Surges of PRL secretion occur in response to relief from hypothalamic dopaminergic inhibition and stimulation by hypothalamic releasing neurohormones. In this study, we characterized the role of oxytocin (OT) in this system and the involvement of vasoactive intestinal polypeptide (VIP) from the suprachiasmatic nucleus (SCN) in controlling OT and PRL secretion of CS rats. The effect of OT on PRL secretion was demonstrated in cultured lactotrophs showing simultaneous enhanced secretion rate and increased intracellular Ca(2+). Neurosecretory OT cells of the hypothalamic paraventricular nucleus that express VIP receptors were identified by using immunocytochemical techniques in combination with the retrogradely transported neuronal tracer Fluoro-Gold (iv injected). OT measurements of serial blood samples obtained from ovariectomized (OVX) CS rats displayed a prominent increase at the time of the afternoon PRL peak. The injection of VIP antisense oligonucleotides into the SCN abolished the afternoon increase of OT and PRL in CS-OVX animals. These findings suggest that VIP from the SCN contributes to the regulation of OT and PRL secretion in CS rats. We propose that in CS rats the regulatory mechanism(s) for PRL secretion comprise coordinated action of neuroendocrine dopaminergic and OT cells, both governed by the daily rhythm of VIP-ergic output from the SCN. This hypothesis is illustrated with a mathematical model. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Egli M, Ber…
parameter: 756108
compartment: 756081
units def: 676193
units def: 676289
parameter: 756114
parameter: 756102
parameter: 756117
volume units: 970346
rule: 756099
area units: area
rule: 756085
rule: 756083
parameter: 756125
rule: 756090
parameter: 756128
units def: 676121
substance units: 608838
parameter: 756121
parameter: 756134
parameter: 756100
time units: 676289
parameter: 756131
rule: 756096
parameter: 756105
is described by: http://identifiers.org/pubmed/15033917
name: Egli2004_ProlactinRhythmicSecretion
parameter: 756143
units def: 676157
units def: 676073
length unit: 027038
parameter: 756111
parameter: 756146
parameter: 756140

756137
type: Parameter
constant: true
units: 676241
value: 500.0
name: vObar

676241
type: SBMLUnitsDef
unit: 676277
unit: 676265
unit: 676253
name: picog_ml_hr

676277
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

676265
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE

676253
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: GRAM

756122
type: Parameter
constant: true
units: 676121
value: 20000.0
name: DA_infinity

676121
type: SBMLUnitsDef
unit: 676145
unit: 676133
name: nanog_ml

676145
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE

676133
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM

676097
type: SBMLUnitsDef
unit: 676109
name: first_order_rate_constant

676109
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

756108
type: Parameter
constant: true
units: 676193
value: 300000.0
name: rP

676193
type: SBMLUnitsDef
unit: 676229
unit: 676217
unit: 676205
name: nanog_ml_hr

676229
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

676217
type: SBMLUnit
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scale: -3
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kind: LITRE

676205
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM

756081
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

676289
type: SBMLUnitsDef
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name: time

676301
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

756114
type: Parameter
constant: false
units: 676121
value: 20000.0
name: DA

756102
type: Parameter
constant: true
units: 676121
value: 300.0
name: kD

756117
type: Parameter
constant: false
units: 676193
value: NaN
name: vD

756125
type: Parameter
constant: true
units: 676097
value: 0.2
name: qD

756128
type: Parameter
constant: false
units: 676157
value: 25.0
name: OT

676157
type: SBMLUnitsDef
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unit: 676169
name: picog_ml

676181
type: SBMLUnit
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scale: -3
multipler: 1.0
kind: LITRE

676169
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: GRAM

756121
type: Parameter
constant: true
units: 676193
value: 10000.0
name: vDbar

756134
type: Parameter
constant: false
units: 676241
value: NaN
name: vO

756100
type: Parameter
constant: false
units: 676121
value: 20.0
name: PRL

756131
type: Parameter
constant: true
units: 676157
value: 50.0
name: kx

756105
type: Parameter
constant: true
units: 676157
value: 9.0
name: kO

756143
type: Parameter
constant: true
units: 676097
value: 1.0
name: qO

676073
type: SBMLUnitsDef
unit: 676085
name: hour

676085
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

756111
type: Parameter
constant: true
units: 676097
value: 0.5
name: qP

756146
type: Parameter
constant: false
units: 676157
value: NaN
name: x

756140
type: Parameter
constant: true
units: 676241
value: 1100.0
name: rO