MODEL0912180000
type: SBMLModel
modified:
  W3 CDTF: Sun Mar 21 17:39:51 GMT 2010
notes: Attention: As this model cannot be encoded in SBML at this time, the SBML file contains the whole model in GINML , a different XML model description language, in its main annotation element. Still, the model can be loaded by GINsim as it is by just ignoring the error messages. Alternatively, you can remove the surrounding SBML elements in a text editor and save the remaining GINsim file with the suffix .ginml . To do this keep the first line with the xml declaration and all lines starting from <gxl xmlns="http://gin.univ-mrs.fr/GINsim/" xmlns:xlink="http://www.w3.org/1999/xlink"> until </glx> and delete or comment out all others. This is the master model described in: Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement Calzone L, Tournier L, Fourquet S, Thieffry D, Zhivotovsky B, Barillot E and Zinovyev A.; PLoS Comput Biol. 2010 Mar 5; 6(3) :e1000702. PubmedID: 20221256 ; doi: 10.1371/journal.pcbi.1000702 ; Abstract: Cytokines such as TNF and FASL can trigger death or survival depending on cell lines and cellular conditions. The mechanistic details of how a cell chooses among these cell fates are still unclear. The understanding of these processes is important since they are altered in many diseases, including cancer and AIDS. Using a discrete modelling formalism, we present a mathematical model of cell fate decision recapitulating and integrating the most consistent facts extracted from the literature. This model provides a generic high-level view of the interplays between NFkappaB pro-survival pathway, RIP1-dependent necrosis, and the apoptosis pathway in response to death receptor-mediated signals. Wild type simulations demonstrate robust segregation of cellular responses to receptor engagement. Model simulations recapitulate documented phenotypes of protein knockdowns and enable the prediction of the effects of novel knockdowns. In silico experiments simulate the outcomes following ligand removal at different stages, and sugges…
volume units: 970346
length unit: 027038
curated: false
time units: 659290
is described by: http://identifiers.org/pubmed/20221256
modified:
  W3 CDTF: Sun Mar 21 17:39:51 GMT 2010
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
creator:
  ORG:
    orgname: EMBL-EBI
  n:
    given: Lukas
    family: Endler
name: Calzone2010_Cellfate_Master_Model
substance units: 608838
created:
  W3 CDTF: Mon Mar 15 22:56:10 GMT 2010
modified:
  W3 CDTF: Sun Mar 21 17:39:51 GMT 2010
area units: area