MODEL0912096133
type: SBMLModel
is described by: http://identifiers.org/pubmed/17185408
rule: 889803
parameter: 889863
parameter: 889855
parameter: 889830
parameter: 889822
parameter: 889836
volume units: volume
parameter: 889816
area units: area
parameter: 889873
parameter: 889845
parameter: 889869
parameter: 889849
parameter: 889878
units def: 635052
parameter: 889839
rule: 889814
parameter: 889872
parameter: 889819
parameter: 889852
curated: false
parameter: 889824
parameter: 889821
substance units: 608838
parameter: 889825
compartment: 889801
rule: 889805
units def: 634956
parameter: 889875
parameter: 889867
parameter: 889842
parameter: 889854
parameter: 889834
rule: 889812
rule: 889811
parameter: 889848
parameter: 889828
parameter: 889857
length unit: 027038
parameter: 889860
notes: This a model from the article: Model-projected mechanistic bases for sex differences in growth hormone regulation in humans. Farhy LS, Bowers CY, Veldhuis JD. Am J Physiol Regul Integr Comp Physiol 2007 Apr;292(4):R1577-93 17185408 , Abstract: Models of physiological systems facilitate rational experimental design, inference, and prediction. A recent construct of regulated growth hormone (GH) secretion interlinks the actions of GH-releasing hormone (GHRH), somatostatin (SRIF), and GH secretagogues (GHS) with GH feedback in the rat (Farhy LS, Veldhuis JD. Am J Physiol Regul Integr Comp Physiol 288: R1649-R1663, 2005). In contrast, no comparable formalism exists to explicate GH dynamics in any other species. The present analyses explore whether a unifying model structure can represent species- and sex-defined distinctions in the human and rodent. The consensus principle that GHRH and GHS synergize in vivo but not in vitro was explicable by assuming that GHS 1) evokes GHRH release from the brain, 2) opposes inhibition by SRIF both in the hypothalamus and on the pituitary gland, and 3) stimulates pituitary GH release directly and additively with GHRH. The gender-selective principle that GH pulses are larger and more irregular in women than men was conferrable by way of 4) higher GHRH potency and 5) greater GHS efficacy. The overall construct predicts GHRH/GHS synergy in the human only in the presence of SRIF when the brain-pituitary nexus is intact, larger and more irregular GH pulses in women, and observed gender differences in feedback by GH and the single and paired actions of GHRH, GHS, and SRIF. The proposed model platform should enhance the framing and interpretation of novel clinical hypotheses and create a basis for interspecies generalization of GH-axis regulation. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Farhy LS, Bowers CY, Veldhuis JD. (2007) - version03 The original CellML model was created…
parameter: 889858
time units: 635100
units def: 635004
units def: 634920
rule: 889815
parameter: 889818
parameter: 889851
parameter: 889831
parameter: 889870
parameter: 889843
parameter: 889864
parameter: 889861
parameter: 889876
parameter: 889833
parameter: 889837
rule: 889806
rule: 889809
rule: 889808
parameter: 889866
parameter: 889846
units def: 635076
name: Farhy2007_hGHregulation
parameter: 889827
units def: 635100
units def: 634884
parameter: 889840

889863
type: Parameter
constant: true
units: dimensionless
value: 390.0
name: tg1

889855
type: Parameter
constant: true
units: dimensionless
value: 5.0
name: n4

889830
type: Parameter
constant: true
units: dimensionless
value: 200.0
name: tg0

889822
type: Parameter
constant: true
units: 634920
value: 357.0
name: t1

634920
type: SBMLUnitsDef
unit: 634944
unit: 634932
name: pg_ml

634944
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE

634932
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: GRAM

889836
type: Parameter
constant: true
units: 635004
value: 20400.0
name: kr4

635004
type: SBMLUnitsDef
unit: 635040
unit: 635028
unit: 635016
name: pg_ml_hr

635040
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

635028
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE

635016
type: SBMLUnit
exponent: 1.0
scale: -12
multipler: 1.0
kind: GRAM

889816
type: Parameter
constant: false
units: 634884
value: 0.0
name: GH

634884
type: SBMLUnitsDef
unit: 634908
unit: 634896
name: ng_ml

634908
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE

634896
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM

889873
type: Parameter
constant: true
units: 635076
value: 15.0
name: kghr

635076
type: SBMLUnitsDef
unit: 635088
name: first_order_rate_constant

635088
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

889845
type: Parameter
constant: true
units: 635004
value: 2200.0
name: kr2

889869
type: Parameter
constant: false
units: 634920
value: 0.0
name: ghr_GHRH

889849
type: Parameter
constant: false
units: 634920
value: 0.0
name: GHRH

889878
type: Parameter
constant: true
units: 635052
value: 0.2
name: duration

635052
type: SBMLUnitsDef
unit: 635064
name: hour

635064
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

889839
type: Parameter
constant: true
units: dimensionless
value: 2.0
name: n5

889872
type: Parameter
constant: false
units: 635004
value: NaN
name: inject

889819
type: Parameter
constant: true
units: 635076
value: 3.0
name: k1

889852
type: Parameter
constant: true
units: 635004
value: 63000.0
name: kr3

889824
type: Parameter
constant: true
units: dimensionless
value: 5.0
name: n1

889821
type: Parameter
constant: true
units: 634956
value: 600.0
name: kr1

634956
type: SBMLUnitsDef
unit: 634992
unit: 634980
unit: 634968
name: ng_ml_hr

634992
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 3600.0
kind: SECOND

634980
type: SBMLUnit
exponent: -1.0
scale: -3
multipler: 1.0
kind: LITRE

634968
type: SBMLUnit
exponent: 1.0
scale: -9
multipler: 1.0
kind: GRAM

889825
type: Parameter
constant: true
units: dimensionless
value: 2.0
name: n2

889801
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

889875
type: Parameter
constant: true
units: 635004
value: 10000.0
name: C

889867
type: Parameter
constant: true
units: dimensionless
value: 2.0
name: ng2

889842
type: Parameter
constant: false
units: 634920
value: 0.0
name: SRIF_ArC

889854
type: Parameter
constant: true
units: 634920
value: 28.0
name: t4

889834
type: Parameter
constant: true
units: 635076
value: 25.0
name: k4

889848
type: Parameter
constant: true
units: dimensionless
value: 2.0
name: n3

889828
type: Parameter
constant: true
units: dimensionless
value: 2.9
name: ng0

889857
type: Parameter
constant: false
units: dimensionless
value: NaN
name: F1_GHS

889860
type: Parameter
constant: true
units: dimensionless
value: 90000.0
name: g1

889858
type: Parameter
constant: false
units: dimensionless
value: NaN
name: F2_GHS

635100
type: SBMLUnitsDef
unit: 635112
name: time

635112
type: SBMLUnit
exponent: 1.0
scale: 0
multipler: 3600.0
kind: SECOND

889818
type: Parameter
constant: true
units: dimensionless
value: 20.0
name: GHS

889851
type: Parameter
constant: true
units: 635076
value: 40.0
name: k3

889831
type: Parameter
constant: true
units: 634920
value: 10.0
name: t2

889870
type: Parameter
constant: false
units: 635004
value: NaN
name: dghr_GHRH_dt

889843
type: Parameter
constant: true
units: 635076
value: 25.0
name: k2

889864
type: Parameter
constant: true
units: dimensionless
value: 10000.0
name: tg2

889861
type: Parameter
constant: true
units: dimensionless
value: 100.0
name: g2

889876
type: Parameter
constant: true
units: 635052
value: 2.0
name: onset

889833
type: Parameter
constant: false
units: 634920
value: 0.0
name: SRIF_PeV

889837
type: Parameter
constant: true
units: 634884
value: 10.0
name: t5

889866
type: Parameter
constant: true
units: dimensionless
value: 3.0
name: ng1

889846
type: Parameter
constant: true
units: 634920
value: 400.0
name: t3

889827
type: Parameter
constant: true
units: dimensionless
value: 2.0
name: g0

889840
type: Parameter
constant: true
units: 635004
value: 900.0
name: S_basal