MODEL0911270008
type: SBMLModel
parameter: 331845
rule: 331832
compartment: 331827
notes: This a model from the article: Infection dynamics in HIV-specific CD4 T cells: does a CD4 T cell boost benefit the host or the virus? Wodarz D, Hamer DH. Math Biosci 2007 Sep;209(1):14-29 17379260 , Abstract: Recent experimental data have shown that HIV-specific CD4 T cells provide a very important target for HIV replication. We use mathematical models to explore the effect of specific CD4 T cell infection on the dynamics of virus spread and immune responses. Infected CD4 T cells can provide antigen for their own stimulation. We show that such autocatalytic cell division can significantly enhance virus spread, and can also provide an additional reservoir for virus persistence during anti-viral drug therapy. In addition, the initial number of HIV-specific CD4 T cells is an important determinant of acute infection dynamics. A high initial number of HIV-specific CD4 T cells can lead to a sudden and fast drop of the population of HIV-specific CD4 T cells which results quickly in their extinction. On the other hand, a low initial number of HIV-specific CD4 T cells can lead to a prolonged persistence of HIV-specific CD4 T cell help at higher levels. The model suggests that boosting the population of HIV-specific CD4 T cells can increase the amount of virus-induced immune impairment, lead to less efficient anti-viral effector responses, and thus speed up disease progression, especially if effector responses such as CTL have not been sufficiently boosted at the same time. This model was taken from the CellML repository and automatically converted to SBML. The original model was: Wodarz D, Hamer DH. (2007) - version02 This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Do…
substance units: 573275
rule: 331831
parameter: 331834
time units: 577459
parameter: 331839
parameter: 331848
is described by: http://identifiers.org/pubmed/17379260
curated: false
units def: 593121
volume units: volume
area units: area
parameter: 331842
parameter: 331835
length unit: 027038
parameter: 331836

331845
type: Parameter
constant: true
units: 593121
value: 0.5
name: u

593121
type: SBMLUnitsDef
unit: 593133
name: first_order_rate_constant

593133
type: SBMLUnit
exponent: -1.0
scale: 0
multipler: 1.0
kind: SECOND

331827
type: Compartment
constant: true
units: litre
size: 1.0
spatial dimensions: 3.0

331834
type: Parameter
constant: false
units: dimensionless
value: 0.0
name: y

331839
type: Parameter
constant: true
units: dimensionless
value: 10.0
name: k

331848
type: Parameter
constant: true
units: 593121
value: 1.0
name: eta

331842
type: Parameter
constant: false
units: dimensionless
value: 1.0
name: v

331835
type: Parameter
constant: true
units: 593121
value: 1.0
name: r

331836
type: Parameter
constant: true
units: 593121
value: 0.2
name: a